Miniaturized metalloproteins: Application to iron-sulfur proteins (653 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
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Paper type: Journal Article,
Impact factor: 10.789, 5-year impact factor: 10.727
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034710939&partnerID=40&md5=93eba1a214f54e4a52b00eb00e9f3bac
Keywords: Copper Ion, Cysteine, Ferric Ion, Ferrous Ion, Iron Binding Protein, Iron Sulfur Protein, Metal Complex, Metal Ion, Metalloprotein, Miniaturized Electron Transfer Protein, Rubredoxin, Unclassified Drug, Zinc Ion, Amino Acid Sequence, Article, Circular Dichroism, Controlled Study, Desulfovibrio Vulgaris, Metal Binding, Methodology, Molecular Model, Nonhuman, Nuclear Magnetic Resonance, Priority Journal, Protein Synthesis, Stoichiometry, Structure Analysis, Ultraviolet Radiation, Iron-Sulfur Proteins, Miniaturization, Biomolecular, Protein Binding, Spectrophotometry, Bacteria (microorganisms),
Affiliations:
Department of Chemistry, University of Napoli Federico II, Via Mezzocannone 4, I-80134 Napoli, Italy
Ctro. di Stud. di Biocristallografia, C.N.R., Via Mezzocannone 4, 1-80134 Napoli, Italy
References:
Cunningham, B.C., Wells, J.A., (1997) Curr. Opin. Struct. Biol., 7, pp. 457-46
DeGrado, W.F., Summa, C.M., Pavone, V., Nastri, F., Lombardi, A., (1999) Annu. Rev. Biochem., 68, pp. 779-819
Regan, L., (1995) Trends Biochem. Sci., 20, pp. 280-285
Hellinga, H.W., (1998) Folding Des., 3, pp. R1-R8
Lu, Y., Valentine, J.S., (1997) Curr. Opin. Struct. Biol., 7, pp. 495-500
Lippard, S.J., Berg, J.M., (1994) Principles of Bioinorganic Chemistry, pp. 349-378. , University Science Books, Mill Valley, CA
Choma, C.T., Lear, J.D., Nelson, M.J., Dutton, P.L., Robertson, D.E., DeGrado, W.F., (1994) J. Am. Chem. Soc., 116, pp. 856-865
Gibney, B.R., Mulholland, S.E., Rabanal, F., Dutton, P.L., (1996) Proc. Natl. Acad. Sci. USA, 93, pp. 15041-15046
Arnold, P.A., Shelton, W.R., Benson, D.R., (1997) J. Am. Chem. Soc., 119, pp. 3181-3182
Sakamoto, S., Ueno, A., Mihara, H., (1998) J. Chem. Soc. Perkin Trans., 2, pp. 2395-2404
D'Auria, G., Maglio, O., Nastri, F., Lombardi, A., Mazzeo, M., Morelli, G., Paolillo, L., Pavone, V., (1997) Chem. Eur. J., 3, pp. 350-362
Lombardi, A., Nastri, F., Sanseverino, M., Maglio, O., Pedone, C., Pavone, V., (1998) Inorg. Chim. Acta, 276, pp. 301-313
Lombardi, A., Summa, C., Geremia, S., Randaccio, L., Pavone, V., DeGrado, W.F., (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 6298-6305
Summa, C.M., Lombardi, A., Lewis, M., DeGrado, W.F., (1999) Curr. Opin. Struct. Biol., 9, pp. 500-508
Sieker, L.C., Stenkamp, R.E., Legall, J., (1994) Methods Enzymol., 243, pp. 203-216
Bau, R., Rees, D.C., Kurtz, D.M., Scott, J.A.R., (1998) J. Biol. Inorg. Chem., 3, pp. 484-493
Dauter, Z., Sieker, L.C., Wilson, K.S., (1992) Acta Crystallogr. B, 48, pp. 42-59
Misaki, S., Morimoto, Y., Ogata, M., Yagi, T., Higuchi, Y., Yasuoka, N., (1999) Acta Crystallogr. D, 55, pp. 408-413
Watenpaugh, K.D., Sieker, L.C., Jensen, L.H., (1980) J. Mol. Biol., 138, pp. 615-633
Bertini, I., Kurtz, D.M., Eidsness Jr., M.K., Liu, G., Luchinat, C., Rosato, A., Scott, R.A., (1998) J. Biol. Inorg. Chem., 3, pp. 401-410
Im, S.-C., Sykes, A.G., (1996) J. Chem. Soc. Dalton Trans., pp. 2219-2222
Zeng, Q., Smith, E.T., Kurtz Jr., D.M., Scott, R.A., (1996) Inorg. Chim. Acta, 242, pp. 245-251
Richie, K.A., Teng, Q., Elkin, C.J., Kurtz Jr., D.M., (1996) Protein Sci., 5, pp. 883-894
Blake, P.R., Park, J.-B., Zhou, Z.H., Hare, D.R., Adam, M.W., Summers, M.F., (1992) Protein Sci., 1, pp. 1508-1521
Maher, M.J., Xiao, Z., Wilce, M.C.J., Guss, M., Wedd, A.G., (1999) Acta Crystallogr. D, 55, pp. 962-968
Kummerle, R., Zhuang-Jackson, H., Gaillard, J., Moulis, J.M., (1997) Biochemistry, 36, pp. 15983-15991
Eidness, M.K., Burden, A.E., Richie, K.A., Kurtz, D.M., Scott, R.A., Smith, E.T., Ichiye, T., Kang, C., (1999) Biochemistry, 38, pp. 14803-14809
May, S.W., Kuo, J.Y., (1978) Biochemistry, 17, pp. 3333-3338
Moura, I., Teixeira, M., Legall, J., Moura, J.J.G., (1991) J. Inorg. Biochem., 44, pp. 127-139
Christensen, M., Hammerstad-Pedersen, J.M., Holm, A., Iversen, G., Jensen, M.H., Ulstrup, J., (1994) Eur. J. Biochem., 224, pp. 97-101
Christensen, H.E.M., Hammerstad-Pedersen, J.M., Holm, A., Roepstorff, P., Ulstrup, J., Vorm, O., Ostergard, S., (1992) FEBS Lett., 312, pp. 219-222
Millar, M., Lee, J.F., O'Sullivan, T., Koch, S.A., Fikar, R., (1996) Inorg. Chim. Acta, 243, pp. 333-343
Ueyama, N., Nakata, M., Nakamura, A., (1981) Bull. Chem. Soc. Jpn., 54, pp. 1727-1730
Anglin, J.R., Davison, A., (1975) Inorg. Chem., 14, pp. 234-237
Lane, R.W., Ibers, J.A., Frankel, R.B., Papaefthymiou, G.C., Holm, R.H., (1977) J. Am. Chem. Soc., 99, pp. 84-98
Farinas, E., Regan, L., (1998) Protein Sci., 7, pp. 1939-1946
Benson, D.E., Wisz, M.S., Liu, W., Hellinga, H.W., (1998) Biochemistry, 37, pp. 7070-7076
Berg, J.M., Merkle, D.L., (1989) J. Am. Chem. Soc., 111, pp. 3759-3761
Krisek, B.A., Merkle, D.L., Berg, J.M., (1993) Inorg. Chem., 32, pp. 937-940
Wuthrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley, New York
Pavone, V., (1988) Int. J. Biol. Macromol., 10, pp. 238-240
Pavone, V., Gaeta, G., Lombardi, A., Nastri, F., Maglio, O., Isernia, C., Saviano, M., (1996) Biopolymers, 38, pp. 705-721
Gunasekaran, K., Ramakrishnan, C., Balaram, P., (1997) Protein Eng., 10, pp. 1131-1141
Pavone, V., Di Blasio, B., Santini, A., Benedetti, E., Pedone, C., Toniolo, C., Crisma, M., (1990) J. Mol. Biol., 214, pp. 633-635
Bertini, I., Luchinat, C., (1984) Adv. Inorg. Biochim., 6, pp. 71-111
Fasman, G.D., (1996) Circular Dichroism and Conformationl Analysis of Biomolecules, , Plenum, New York
Cunningham, B. C., Wells, J. A., (1997) Curr. Opin. Struct. Biol., 7, pp. 457-46
DeGrado, W. F., Summa, C. M., Pavone, V., Nastri, F., Lombardi, A., (1999) Annu. Rev. Biochem., 68, pp. 779-819
Hellinga, H. W., (1998) Folding Des., 3, pp. R1-R8
Lippard, S. J., Berg, J. M., (1994) Principles of Bioinorganic Chemistry, pp. 349-378. , University Science Books, Mill Valley, CA
Choma, C. T., Lear, J. D., Nelson, M. J., Dutton, P. L., Robertson, D. E., DeGrado, W. F., (1994) J. Am. Chem. Soc., 116, pp. 856-865
Gibney, B. R., Mulholland, S. E., Rabanal, F., Dutton, P. L., (1996) Proc. Natl. Acad. Sci. USA, 93, pp. 15041-15046
Arnold, P. A., Shelton, W. R., Benson, D. R., (1997) J. Am. Chem. Soc., 119, pp. 3181-3182
Summa, C. M., Lombardi, A., Lewis, M., DeGrado, W. F., (1999) Curr. Opin. Struct. Biol., 9, pp. 500-508
Sieker, L. C., Stenkamp, R. E., Legall, J., (1994) Methods Enzymol., 243, pp. 203-216
Bau, R., Rees, D. C., Kurtz, D. M., Scott, J. A. R., (1998) J. Biol. Inorg. Chem., 3, pp. 484-493
Watenpaugh, K. D., Sieker, L. C., Jensen, L. H., (1980) J. Mol. Biol., 138, pp. 615-633
Im, S. -C., Sykes, A. G., (1996) J. Chem. Soc. Dalton Trans., pp. 2219-2222
Richie, K. A., Teng, Q., Elkin, C. J., Kurtz Jr., D. M., (1996) Protein Sci., 5, pp. 883-894
Blake, P. R., Park, J. -B., Zhou, Z. H., Hare, D. R., Adam, M. W., Summers, M. F., (1992) Protein Sci., 1, pp. 1508-1521
Maher, M. J., Xiao, Z., Wilce, M. C. J., Guss, M., Wedd, A. G., (1999) Acta Crystallogr. D, 55, pp. 962-968
Eidness, M. K., Burden, A. E., Richie, K. A., Kurtz, D. M., Scott, R. A., Smith, E. T., Ichiye, T., Kang, C., (1999) Biochemistry, 38, pp. 14803-14809
May, S. W., Kuo, J. Y., (1978) Biochemistry, 17, pp. 3333-3338
Christensen, H. E. M., Hammerstad-Pedersen, J. M., Holm, A., Roepstorff, P., Ulstrup, J., Vorm, O., Ostergard, S., (1992) FEBS Lett., 312, pp. 219-222
Anglin, J. R., Davison, A., (1975) Inorg. Chem., 14, pp. 234-237
Lane, R. W., Ibers, J. A., Frankel, R. B., Papaefthymiou, G. C., Holm, R. H., (1977) J. Am. Chem. Soc., 99, pp. 84-98
Benson, D. E., Wisz, M. S., Liu, W., Hellinga, H. W., (1998) Biochemistry, 37, pp. 7070-7076
Berg, J. M., Merkle, D. L., (1989) J. Am. Chem. Soc., 111, pp. 3759-3761
Krisek, B. A., Merkle, D. L., Berg, J. M., (1993) Inorg. Chem., 32, pp. 937-940
Fasman, G. D., (1996) Circular Dichroism and Conformationl Analysis of Biomolecules, , Plenum, New York
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 10.789, 5-year impact factor: 10.727
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034710939&partnerID=40&md5=93eba1a214f54e4a52b00eb00e9f3bac
Keywords: Copper Ion, Cysteine, Ferric Ion, Ferrous Ion, Iron Binding Protein, Iron Sulfur Protein, Metal Complex, Metal Ion, Metalloprotein, Miniaturized Electron Transfer Protein, Rubredoxin, Unclassified Drug, Zinc Ion, Amino Acid Sequence, Article, Circular Dichroism, Controlled Study, Desulfovibrio Vulgaris, Metal Binding, Methodology, Molecular Model, Nonhuman, Nuclear Magnetic Resonance, Priority Journal, Protein Synthesis, Stoichiometry, Structure Analysis, Ultraviolet Radiation, Iron-Sulfur Proteins, Miniaturization, Biomolecular, Protein Binding, Spectrophotometry, Bacteria (microorganisms),
Affiliations:
Department of Chemistry, University of Napoli Federico II, Via Mezzocannone 4, I-80134 Napoli, Italy
Ctro. di Stud. di Biocristallografia, C.N.R., Via Mezzocannone 4, 1-80134 Napoli, Italy
References:
Cunningham, B.C., Wells, J.A., (1997) Curr. Opin. Struct. Biol., 7, pp. 457-46
DeGrado, W.F., Summa, C.M., Pavone, V., Nastri, F., Lombardi, A., (1999) Annu. Rev. Biochem., 68, pp. 779-819
Regan, L., (1995) Trends Biochem. Sci., 20, pp. 280-285
Hellinga, H.W., (1998) Folding Des., 3, pp. R1-R8
Lu, Y., Valentine, J.S., (1997) Curr. Opin. Struct. Biol., 7, pp. 495-500
Lippard, S.J., Berg, J.M., (1994) Principles of Bioinorganic Chemistry, pp. 349-378. , University Science Books, Mill Valley, CA
Choma, C.T., Lear, J.D., Nelson, M.J., Dutton, P.L., Robertson, D.E., DeGrado, W.F., (1994) J. Am. Chem. Soc., 116, pp. 856-865
Gibney, B.R., Mulholland, S.E., Rabanal, F., Dutton, P.L., (1996) Proc. Natl. Acad. Sci. USA, 93, pp. 15041-15046
Arnold, P.A., Shelton, W.R., Benson, D.R., (1997) J. Am. Chem. Soc., 119, pp. 3181-3182
Sakamoto, S., Ueno, A., Mihara, H., (1998) J. Chem. Soc. Perkin Trans., 2, pp. 2395-2404
D'Auria, G., Maglio, O., Nastri, F., Lombardi, A., Mazzeo, M., Morelli, G., Paolillo, L., Pavone, V., (1997) Chem. Eur. J., 3, pp. 350-362
Lombardi, A., Nastri, F., Sanseverino, M., Maglio, O., Pedone, C., Pavone, V., (1998) Inorg. Chim. Acta, 276, pp. 301-313
Lombardi, A., Summa, C., Geremia, S., Randaccio, L., Pavone, V., DeGrado, W.F., (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 6298-6305
Summa, C.M., Lombardi, A., Lewis, M., DeGrado, W.F., (1999) Curr. Opin. Struct. Biol., 9, pp. 500-508
Sieker, L.C., Stenkamp, R.E., Legall, J., (1994) Methods Enzymol., 243, pp. 203-216
Bau, R., Rees, D.C., Kurtz, D.M., Scott, J.A.R., (1998) J. Biol. Inorg. Chem., 3, pp. 484-493
Dauter, Z., Sieker, L.C., Wilson, K.S., (1992) Acta Crystallogr. B, 48, pp. 42-59
Misaki, S., Morimoto, Y., Ogata, M., Yagi, T., Higuchi, Y., Yasuoka, N., (1999) Acta Crystallogr. D, 55, pp. 408-413
Watenpaugh, K.D., Sieker, L.C., Jensen, L.H., (1980) J. Mol. Biol., 138, pp. 615-633
Bertini, I., Kurtz, D.M., Eidsness Jr., M.K., Liu, G., Luchinat, C., Rosato, A., Scott, R.A., (1998) J. Biol. Inorg. Chem., 3, pp. 401-410
Im, S.-C., Sykes, A.G., (1996) J. Chem. Soc. Dalton Trans., pp. 2219-2222
Zeng, Q., Smith, E.T., Kurtz Jr., D.M., Scott, R.A., (1996) Inorg. Chim. Acta, 242, pp. 245-251
Richie, K.A., Teng, Q., Elkin, C.J., Kurtz Jr., D.M., (1996) Protein Sci., 5, pp. 883-894
Blake, P.R., Park, J.-B., Zhou, Z.H., Hare, D.R., Adam, M.W., Summers, M.F., (1992) Protein Sci., 1, pp. 1508-1521
Maher, M.J., Xiao, Z., Wilce, M.C.J., Guss, M., Wedd, A.G., (1999) Acta Crystallogr. D, 55, pp. 962-968
Kummerle, R., Zhuang-Jackson, H., Gaillard, J., Moulis, J.M., (1997) Biochemistry, 36, pp. 15983-15991
Eidness, M.K., Burden, A.E., Richie, K.A., Kurtz, D.M., Scott, R.A., Smith, E.T., Ichiye, T., Kang, C., (1999) Biochemistry, 38, pp. 14803-14809
May, S.W., Kuo, J.Y., (1978) Biochemistry, 17, pp. 3333-3338
Moura, I., Teixeira, M., Legall, J., Moura, J.J.G., (1991) J. Inorg. Biochem., 44, pp. 127-139
Christensen, M., Hammerstad-Pedersen, J.M., Holm, A., Iversen, G., Jensen, M.H., Ulstrup, J., (1994) Eur. J. Biochem., 224, pp. 97-101
Christensen, H.E.M., Hammerstad-Pedersen, J.M., Holm, A., Roepstorff, P., Ulstrup, J., Vorm, O., Ostergard, S., (1992) FEBS Lett., 312, pp. 219-222
Millar, M., Lee, J.F., O'Sullivan, T., Koch, S.A., Fikar, R., (1996) Inorg. Chim. Acta, 243, pp. 333-343
Ueyama, N., Nakata, M., Nakamura, A., (1981) Bull. Chem. Soc. Jpn., 54, pp. 1727-1730
Anglin, J.R., Davison, A., (1975) Inorg. Chem., 14, pp. 234-237
Lane, R.W., Ibers, J.A., Frankel, R.B., Papaefthymiou, G.C., Holm, R.H., (1977) J. Am. Chem. Soc., 99, pp. 84-98
Farinas, E., Regan, L., (1998) Protein Sci., 7, pp. 1939-1946
Benson, D.E., Wisz, M.S., Liu, W., Hellinga, H.W., (1998) Biochemistry, 37, pp. 7070-7076
Berg, J.M., Merkle, D.L., (1989) J. Am. Chem. Soc., 111, pp. 3759-3761
Krisek, B.A., Merkle, D.L., Berg, J.M., (1993) Inorg. Chem., 32, pp. 937-940
Wuthrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley, New York
Pavone, V., (1988) Int. J. Biol. Macromol., 10, pp. 238-240
Pavone, V., Gaeta, G., Lombardi, A., Nastri, F., Maglio, O., Isernia, C., Saviano, M., (1996) Biopolymers, 38, pp. 705-721
Gunasekaran, K., Ramakrishnan, C., Balaram, P., (1997) Protein Eng., 10, pp. 1131-1141
Pavone, V., Di Blasio, B., Santini, A., Benedetti, E., Pedone, C., Toniolo, C., Crisma, M., (1990) J. Mol. Biol., 214, pp. 633-635
Bertini, I., Luchinat, C., (1984) Adv. Inorg. Biochim., 6, pp. 71-111
Fasman, G.D., (1996) Circular Dichroism and Conformationl Analysis of Biomolecules, , Plenum, New York
Cunningham, B. C., Wells, J. A., (1997) Curr. Opin. Struct. Biol., 7, pp. 457-46
DeGrado, W. F., Summa, C. M., Pavone, V., Nastri, F., Lombardi, A., (1999) Annu. Rev. Biochem., 68, pp. 779-819
Hellinga, H. W., (1998) Folding Des., 3, pp. R1-R8
Lippard, S. J., Berg, J. M., (1994) Principles of Bioinorganic Chemistry, pp. 349-378. , University Science Books, Mill Valley, CA
Choma, C. T., Lear, J. D., Nelson, M. J., Dutton, P. L., Robertson, D. E., DeGrado, W. F., (1994) J. Am. Chem. Soc., 116, pp. 856-865
Gibney, B. R., Mulholland, S. E., Rabanal, F., Dutton, P. L., (1996) Proc. Natl. Acad. Sci. USA, 93, pp. 15041-15046
Arnold, P. A., Shelton, W. R., Benson, D. R., (1997) J. Am. Chem. Soc., 119, pp. 3181-3182
Summa, C. M., Lombardi, A., Lewis, M., DeGrado, W. F., (1999) Curr. Opin. Struct. Biol., 9, pp. 500-508
Sieker, L. C., Stenkamp, R. E., Legall, J., (1994) Methods Enzymol., 243, pp. 203-216
Bau, R., Rees, D. C., Kurtz, D. M., Scott, J. A. R., (1998) J. Biol. Inorg. Chem., 3, pp. 484-493
Watenpaugh, K. D., Sieker, L. C., Jensen, L. H., (1980) J. Mol. Biol., 138, pp. 615-633
Im, S. -C., Sykes, A. G., (1996) J. Chem. Soc. Dalton Trans., pp. 2219-2222
Richie, K. A., Teng, Q., Elkin, C. J., Kurtz Jr., D. M., (1996) Protein Sci., 5, pp. 883-894
Blake, P. R., Park, J. -B., Zhou, Z. H., Hare, D. R., Adam, M. W., Summers, M. F., (1992) Protein Sci., 1, pp. 1508-1521
Maher, M. J., Xiao, Z., Wilce, M. C. J., Guss, M., Wedd, A. G., (1999) Acta Crystallogr. D, 55, pp. 962-968
Eidness, M. K., Burden, A. E., Richie, K. A., Kurtz, D. M., Scott, R. A., Smith, E. T., Ichiye, T., Kang, C., (1999) Biochemistry, 38, pp. 14803-14809
May, S. W., Kuo, J. Y., (1978) Biochemistry, 17, pp. 3333-3338
Christensen, H. E. M., Hammerstad-Pedersen, J. M., Holm, A., Roepstorff, P., Ulstrup, J., Vorm, O., Ostergard, S., (1992) FEBS Lett., 312, pp. 219-222
Anglin, J. R., Davison, A., (1975) Inorg. Chem., 14, pp. 234-237
Lane, R. W., Ibers, J. A., Frankel, R. B., Papaefthymiou, G. C., Holm, R. H., (1977) J. Am. Chem. Soc., 99, pp. 84-98
Benson, D. E., Wisz, M. S., Liu, W., Hellinga, H. W., (1998) Biochemistry, 37, pp. 7070-7076
Berg, J. M., Merkle, D. L., (1989) J. Am. Chem. Soc., 111, pp. 3759-3761
Krisek, B. A., Merkle, D. L., Berg, J. M., (1993) Inorg. Chem., 32, pp. 937-940
Fasman, G. D., (1996) Circular Dichroism and Conformationl Analysis of Biomolecules, , Plenum, New York
Miniaturized metalloproteins: Application to iron-sulfur proteins
The miniaturization process applied to rubredoxins generated a class of peptide-based metalloprotein models, named METP (miniaturized electron transfer protein). The crystal structure of Desulfovibrio vulgaris rubredoxin was selected as a template for the construction of a tetrahedral (S-gamma-Cys)(4) iron-binding site. Analysis of the structure showed that a sphere of 17 Angstrom in diameter, centered on the metal, circumscribes two unconnected approximately Ct symmetry related beta -hairpins, each containing the -Cys-(Aaa)(2)-Cys-sequence. These observations provided a starting point for the design Of an undecapeptide, which self assembles in the presence of tetrahedrally coordinating metal ions. The METP peptide was synthesized in good yield by standard methodologies. Successful assembly of the METP peptide with Co(II), Zn(II), Fe(II/III), in the expected 2:1 stoichiometry, was proven by UV-visible and circular dichroism spectroscopies. UV-visible analysis of the metal complexes indicated the four Cys ligands tetrahedrally arrange around the metal ion, as designed. Circular dichroism measurements on both the free and metal-bound forms revealed that the metal coordination drives the peptide chain to fold into a turned conformation. NMR characterization of the Zn(II)-METP complex fully supported the structure of the designed model. These results prove that METP reproduces the main features of rubredoxin.
The miniaturization process applied to rubredoxins generated a class of peptide-based metalloprotein models, named METP (miniaturized electron transfer protein). The crystal structure of Desulfovibrio vulgaris rubredoxin was selected as a template for the construction of a tetrahedral (S-gamma-Cys)(4) iron-binding site. Analysis of the structure showed that a sphere of 17 Angstrom in diameter, centered on the metal, circumscribes two unconnected approximately Ct symmetry related beta -hairpins, each containing the -Cys-(Aaa)(2)-Cys-sequence. These observations provided a starting point for the design Of an undecapeptide, which self assembles in the presence of tetrahedrally coordinating metal ions. The METP peptide was synthesized in good yield by standard methodologies. Successful assembly of the METP peptide with Co(II), Zn(II), Fe(II/III), in the expected 2:1 stoichiometry, was proven by UV-visible and circular dichroism spectroscopies. UV-visible analysis of the metal complexes indicated the four Cys ligands tetrahedrally arrange around the metal ion, as designed. Circular dichroism measurements on both the free and metal-bound forms revealed that the metal coordination drives the peptide chain to fold into a turned conformation. NMR characterization of the Zn(II)-METP complex fully supported the structure of the designed model. These results prove that METP reproduces the main features of rubredoxin.
Miniaturized metalloproteins: Application to iron-sulfur proteins
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Miniaturized metalloproteins: Application to iron-sulfur proteins
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Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
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Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
* Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity (461 views)
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Impact Factor: 3.205
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Sinopoli A, Magri A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, GrassoG
* The role of copper(II) in the aggregation of human amylin (492 views)
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Impact Factor: 3.585
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (520 views)
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Impact Factor: 2.379
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Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (503 views)
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Impact Factor: 3.534
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Faiella M, Maglio O, Nastri F, Lombardi A, Lista L, Hagen WR, Pavone V
* De Novo Design, Synthesis and Characterisation of MP3, A New Catalytic Four-Helix Bundle Hemeprotein (474 views)
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Impact Factor: 5.831
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Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
* Metal ions affect insulin-degrading enzyme activity (479 views)
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Impact Factor: 3.197
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (431 views)
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Impact Factor: 3.914
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Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (522 views)
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Impact Factor: 3.197
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Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) complexes of rat amylin fragments (357 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721.
Impact Factor: 3.838
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
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Impact Factor: 3.647
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Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E
* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (494 views)
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Impact Factor: 3.603
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1115 views)
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Impact Factor: 5.476
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
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Impact Factor: 3.647
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Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A
* An artificial di-iron oxo-protein with phenol oxidase activity (417 views)
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Impact Factor: 16.058
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Merlino A, Vitagliano L, Howes BD, Verde C, Di Prisco G, Smulevich G, Sica F, Vergara A
* Combined Crystallographic and Spectroscopic Analysis of Trematomus bernacchii Hemoglobin Highlights Analogies and Differences in the Peculiar Oxidation Pathway of Antarctic Fish Hemoglobins (413 views)
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Impact Factor: 2.605
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (400 views)
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Impact Factor: 8.091
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Pappalardo M, Sciacca MFM, Milardi D, Grasso DM, La Rosa C
* Thermodynamics Of Azurin Folding: The Role Of The Copper Ion (303 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2008 Sep; 93(2): 575-581.
Impact Factor: 1.63
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (394 views)
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Impact Factor: 3.379
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Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (444 views)
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Impact Factor: 2.882
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Pastore C, Franzese M, Sica F, Temussi P, Pastore A
* Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin (408 views)
Febs Journal (ISSN: 1742-464x), 2007 Sep; 274(16): 4199-4210.
Impact Factor: 3.396
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Barone V, De Rienzo F, Langella E, Menziani MC, Rega N, Sola M
* A computational protocol to probe the role of solvation effects on the reduction potential of azurin mutants (272 views)
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Impact Factor: 3.73
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Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (669 views)
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Impact Factor: 2.426
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Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (429 views)
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Impact Factor: 2.225
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Grasso D, Milardi D, La Rosa C, Rizzarelli E
* The different role of Cu++ and Zn++ ions in affecting the interaction of prion peptide PrP106-126 with model membranes (283 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2004 Jan 21; 10(2): 246-247.
Impact Factor: 3.997
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Milardi D, Grasso DM, Verbeet MP, Canters GW, La Rosa C
* Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: Synergism among multiple depletions (330 views)
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Impact Factor: 2.338
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Vecchio G
* Ligand exchange chiral separations by cyclodextrin derivatives in capillary electrophoresis (425 views)
Analyst (ISSN: 0003-2654), 2003; 128(2): 134-136.
Impact Factor: 2.251
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Pappalardo G, Impellizzeri G, Bonomo RP, Campagna T, Grasso G, Saita MG
* Copper(II) and nickel(II) binding modes in a histidine-containing model dodecapeptide (331 views)
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Impact Factor: 2.06
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (502 views)
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Impact Factor: 4.698
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Conato C, Contino A, Maccarrone G, Magrì A, Remelli M, Tabbì G
Copper(II) complexes with L-lysine and L-ornithine: Is the side-chain involved in the coordination? A thermodynamic and spectroscopic study (312 views)
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Impact Factor: 0.807
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Nastri F, Lombardi A, D'Andrea LD, Sanseverino M, Maglio O, Pavone V
Miniaturized hemoproteins (423 views)
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1998; 47(1): 5-22.
Impact Factor: 2.086
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Cucinotta V, Grasso D, Grasso G, Milardi D
Calorimetric evidences for Copper(II)-regulated chiral recognition between decanucleotide 5'd(CTGGATCCAG)2 and Ala-Trp dipeptides (394 views)
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Impact Factor: 0.905
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Bonomo RP, Marchelli R, Tabbì G
Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides (512 views)
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Impact Factor: 1.342
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
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Impact Factor: 1.342
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Fattorusso R, Morelli G, Lombardi A, Nastri F, maglio O, D'Auria G, Pedone C, Pavone V
Design of metal ion binding peptides (614 views)
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Impact Factor: 2.425
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* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (462 views)
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Impact Factor: 4.069
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Magrì A, Tabbì G, Breglia R, De Gioia L, Fantucci P, Bruschi M, Bonomo RP, La Mendola D
* Copper ion interaction with the RNase catalytic site fragment of the angiogenin protein: an experimental and theoretical investigation (371 views) (PDF 179 views)
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Impact Factor: 4.099
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Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF
* ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (719 views)
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Impact Factor: 3.348
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Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (422 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
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Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
* Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity (461 views)
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Impact Factor: 3.205
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Sinopoli A, Magri A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, GrassoG
* The role of copper(II) in the aggregation of human amylin (492 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014 Oct; 6(10): 1841-1852.
Impact Factor: 3.585
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (520 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
View Export to BibTeX Export to EndNote
Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (503 views)
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Impact Factor: 3.534
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Faiella M, Maglio O, Nastri F, Lombardi A, Lista L, Hagen WR, Pavone V
* De Novo Design, Synthesis and Characterisation of MP3, A New Catalytic Four-Helix Bundle Hemeprotein (474 views)
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Impact Factor: 5.831
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Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
* Metal ions affect insulin-degrading enzyme activity (479 views)
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Impact Factor: 3.197
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (431 views)
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Impact Factor: 3.914
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Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (522 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
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Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) complexes of rat amylin fragments (357 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721.
Impact Factor: 3.838
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E
* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (494 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Nov 4; 114(43): 13830-13838.
Impact Factor: 3.603
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1115 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A
* An artificial di-iron oxo-protein with phenol oxidase activity (417 views)
Nat Chem Biol (ISSN: 1552-4450), 2009 Dec; 5(12): 882-884.
Impact Factor: 16.058
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Merlino A, Vitagliano L, Howes BD, Verde C, Di Prisco G, Smulevich G, Sica F, Vergara A
* Combined Crystallographic and Spectroscopic Analysis of Trematomus bernacchii Hemoglobin Highlights Analogies and Differences in the Peculiar Oxidation Pathway of Antarctic Fish Hemoglobins (413 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1117-1125.
Impact Factor: 2.605
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (400 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10527-10535.
Impact Factor: 8.091
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Pappalardo M, Sciacca MFM, Milardi D, Grasso DM, La Rosa C
* Thermodynamics Of Azurin Folding: The Role Of The Copper Ion (303 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2008 Sep; 93(2): 575-581.
Impact Factor: 1.63
View Export to BibTeX Export to EndNote
Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (394 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
View Export to BibTeX Export to EndNote
Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (444 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
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Pastore C, Franzese M, Sica F, Temussi P, Pastore A
* Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin (408 views)
Febs Journal (ISSN: 1742-464x), 2007 Sep; 274(16): 4199-4210.
Impact Factor: 3.396
View Export to BibTeX Export to EndNote
Barone V, De Rienzo F, Langella E, Menziani MC, Rega N, Sola M
* A computational protocol to probe the role of solvation effects on the reduction potential of azurin mutants (272 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jan 1; 62(1): 262-269.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (669 views)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
View Export to BibTeX Export to EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (429 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
View Export to BibTeX Export to EndNote
Grasso D, Milardi D, La Rosa C, Rizzarelli E
* The different role of Cu++ and Zn++ ions in affecting the interaction of prion peptide PrP106-126 with model membranes (283 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2004 Jan 21; 10(2): 246-247.
Impact Factor: 3.997
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Milardi D, Grasso DM, Verbeet MP, Canters GW, La Rosa C
* Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: Synergism among multiple depletions (330 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2003 Jun 1; 414(1): 121-127.
Impact Factor: 2.338
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Vecchio G
* Ligand exchange chiral separations by cyclodextrin derivatives in capillary electrophoresis (425 views)
Analyst (ISSN: 0003-2654), 2003; 128(2): 134-136.
Impact Factor: 2.251
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Pappalardo G, Impellizzeri G, Bonomo RP, Campagna T, Grasso G, Saita MG
* Copper(II) and nickel(II) binding modes in a histidine-containing model dodecapeptide (331 views)
New J Chem (ISSN: 1144-0546), 2002; 26(5): 593-600.
Impact Factor: 2.06
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (502 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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Conato C, Contino A, Maccarrone G, Magrì A, Remelli M, Tabbì G
Copper(II) complexes with L-lysine and L-ornithine: Is the side-chain involved in the coordination? A thermodynamic and spectroscopic study (312 views)
Thermochim Acta (ISSN: 0040-6031), 2000 Nov 13; 362(1-2): 13-23.
Impact Factor: 0.807
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Nastri F, Lombardi A, D'Andrea LD, Sanseverino M, Maglio O, Pavone V
Miniaturized hemoproteins (423 views)
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1998; 47(1): 5-22.
Impact Factor: 2.086
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Cucinotta V, Grasso D, Grasso G, Milardi D
Calorimetric evidences for Copper(II)-regulated chiral recognition between decanucleotide 5'd(CTGGATCCAG)2 and Ala-Trp dipeptides (394 views)
Nucleosides Nucleotides (ISSN: 0732-8311), 1997; 16(10-11): 1847-1854.
Impact Factor: 0.905
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Bonomo RP, Marchelli R, Tabbì G
Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides (512 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Nov 15; 60(3): 205-218.
Impact Factor: 1.342
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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Fattorusso R, Morelli G, Lombardi A, Nastri F, maglio O, D'Auria G, Pedone C, Pavone V
Design of metal ion binding peptides (614 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995; 37(6): 401-410.
Impact Factor: 2.425
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39 Records (39 excluding Abstracts).
Total impact factor: 138.794 (138.794 excluding Abstracts).
Total 5 year impact factor: 154.818 (154.818 excluding Abstracts).
Total impact factor: 138.794 (138.794 excluding Abstracts).
Total 5 year impact factor: 154.818 (154.818 excluding Abstracts).
653 views. Last view on Monday 13 March 2023, 5:32:35
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