Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.736, 5-year impact factor: 1.609
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-55649090320&partnerID=40&md5=833f0591f91f86509c5e5262da50e313
Keywords: Micelles, Peptides, Polymerizable, Sans, Surfactants, Abs Resins, Aggregates, Amines, Chelation, Colloids, Hand Held Computers, Hydrophobicity, Monomers, Neutron Scattering, Personal Digital Assistants, Surface Active Agents, Amphiphilic, Before And After, Bioactive Peptides, Cck8 Peptides, Chelating Agents, Gadolinium Complexes, Hydrophilic Heads, Hydrophobic Chains, Mixed Aggregates, Mixed Micelles, Molar Ratios, Phase Syntheses, Polymerization Processes, Relaxivity, Small-Angle Neutron Scatterings, Triple Bonds, Unimers, Uv Irradiations, Amphophile, Carbon, Cholecystokinin Octapeptide, Article, Chemical Bond, Chemical Structure, Contrast Enhancement, Controlled Study, Drug Structure, Fluorescence Analysis, Hydrophilicity, Nuclear Magnetic Resonance Imaging, Priority Journal, Solid Phase Synthesis, Ultraviolet Radiation,
Affiliations:
*** IBB - CNR ***
Dipartimento di Chimica-CSGI, Università degli Studi di Napoli Federico II, via Cinthia, 80126 Naples, Italy
Dipartimento di Scienze Biologiche-CIRPeB, Università degli Studi di Napoli Federico II, via Mezzocannone 16, 80134 Naples, Italy
Jülich Centre for Neutron Science, Forschungszentrum Jülich GmbH, Lichtenbergstrasse 1, 85747 Garching bei München, Germany
CSGI - Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, Florence, Italy
J lich Centre for Neutron Science, Forschungszentrum J lich GmbH, Lichtenbergstrasse 1, 85747 Garching bei M nchen, Germany
References:
Weissleder, R., Mahmood, U., Molecular imaging (2001) Radiology, 219, pp. 316-333. , Oak Brook, IL, United State
Aime, S., Cabella, C., Colombatto, S., Geninatti Crich, S., Gianolio, E., Maggioni, F., Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations (2002) J Magn Reson Imaging Field, 16, pp. 394-406
Aime, S., Fasano, M., Terreno, E., Botta, M., Protein-bound metal chelates (2001) Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, pp. 193-241. , In: Merbach A, Toth E (eds) Wiley, New York
Gao, J., Nasongkla, N., Khemtong, C., cRGD-encoded, MRI-visible polymeric micelles for tumor-targeted drug delivery (2007) Nanotechnology for Cancer Therapy, pp. 465-475. , In: Amiji M (ed) CRC, Boca Raton 1 plate
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor-specific contrast agents in MRI (2004) J Am Chem Soc, 126, pp. 3097-3107
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Teixeira, J., Schillen, K., Aime, S., Morelli, G., Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (2007) ChemBioChem, 8, pp. 950-955
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (2007) ChemPhysChem, 8, pp. 2526-2538
Evans, D.F., (1998) The Colloidal Domain: Where Physics, Chemistry, Biology, and Technology Meet, , 2nd edn. Wiley, New York
Zou, G., Fang, K., Xia, S., He, P., Elasticity of 10,12-pentacosadiynoic acid monolayer and the polymerized monolayer at varying pH and temperatures (2002) Langmuir, 18, pp. 6602-6605
Reubi, J.C., Schaer, J.-C., Waser, B., Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res, 57, pp. 1377-1386
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjug Chem, 10, pp. 137-140
Chan, W.C., White, P.D., (2000) Basic Procedures. Fmoc Solid Phase Peptide Synthesis, pp. 41-76. , Oxford University Press, Oxford
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci Field, 4, pp. 2411-2423
Birdi, K.S., Singh, H.N., Dalsager, S.U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalenesulfonate (1979) J Phys Chem, 83, pp. 2733-2737
De Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., A fluorimetric method for the estimation of the critical micelle concentration of surfactants (1981) Anal Biochem, 115, pp. 278-286
Lakowicz, J.R., (1983) Principles of Fluorescence Spectroscopy, , Springer, New York
Wignall, G.D., Bates, F.S., Absolute calibration of small-angle neutron scattering data (1987) J Appl Crystallogr, 20, pp. 28-40
Russell, T.P., Lin, J.S., Spooner, S., Wignall, G.D., Intercalibration of small-angle x-ray and neutron scattering data (1988) J Appl Crystallogr, 21, pp. 629-638
Shinoda, K., Nakagawa, T., Tamamushi, B., Isemura, T., (1962) Colloidal Surfactants, Some Physicochemical Properties, , Academy, New York
Caravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., Gadolinium(III) Chelates as MRI contrast agents: Structure, dynamics, and applications (1999) Chem Rev (Washington, D. C.), 99, pp. 2293-2352
Lipari, G., Szabo, A., Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity (1982) J Am Chem Soc, 104, pp. 4546-4559
Torres, S., Martins, J.A., Andre, J.P., Geraldes, C.F.G.C., Merbach, A.E., Toth, E., Supramolecular assembly of an amphiphilic GdIII chelate: Tuning the reorientational correlation time and the water exchange rate (2006) Chem-Eur J, 12, pp. 940-948
Nicolle, G.M., Toth, E., Eisenwiener, K.-P., Macke, H.R., Merbach, A.E., From monomers to micelles: Investigation of the parameters influencing proton relaxivity (2002) JBIC, J Biol Inorg Chem, 7, pp. 757-769
Nicolle, G.M., Tóth, É., Schmitt-Willich, H., Radchel, B., Merbach, A.E., The impact of rigidity and water exchange on the relaxivity of a dendritic MRI contrast agent (2002) Chem - Eur J, 8, pp. 1040-1048
Kotlarchyk, M., Chen, S.H., Analysis of small angle neutron scattering spectra from polydisperse interacting colloids (1983) J Chem Phys, 79, pp. 2461-2469
Evans, D. F., (1998) The Colloidal Domain: Where Physics, Chemistry, Biology, and Technology Meet, , 2nd edn. Wiley, New York
Reubi, J. C., Schaer, J. -C., Waser, B., Cholecystokinin (CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res, 57, pp. 1377-1386
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjug Chem, 10, pp. 137-140
Chan, W. C., White, P. D., (2000) Basic Procedures. Fmoc Solid Phase Peptide Synthesis, pp. 41-76. , Oxford University Press, Oxford
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci Field, 4, pp. 2411-2423
Birdi, K. S., Singh, H. N., Dalsager, S. U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalenesulfonate (1979) J Phys Chem, 83, pp. 2733-2737
Lakowicz, J. R., (1983) Principles of Fluorescence Spectroscopy, , Springer, New York
Wignall, G. D., Bates, F. S., Absolute calibration of small-angle neutron scattering data (1987) J Appl Crystallogr, 20, pp. 28-40
Russell, T. P., Lin, J. S., Spooner, S., Wignall, G. D., Intercalibration of small-angle x-ray and neutron scattering data (1988) J Appl Crystallogr, 21, pp. 629-638
Nicolle, G. M., Toth, E., Eisenwiener, K. -P., Macke, H. R., Merbach, A. E., From monomers to micelles: Investigation of the parameters influencing proton relaxivity (2002) JBIC, J Biol Inorg Chem, 7, pp. 757-769
Nicolle, G. M., T th, ., Schmitt-Willich, H., Radchel, B., Merbach, A. E., The impact of rigidity and water exchange on the relaxivity of a dendritic MRI contrast agent (2002) Chem - Eur J, 8, pp. 1040-1048
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.736, 5-year impact factor: 1.609
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-55649090320&partnerID=40&md5=833f0591f91f86509c5e5262da50e313
Keywords: Micelles, Peptides, Polymerizable, Sans, Surfactants, Abs Resins, Aggregates, Amines, Chelation, Colloids, Hand Held Computers, Hydrophobicity, Monomers, Neutron Scattering, Personal Digital Assistants, Surface Active Agents, Amphiphilic, Before And After, Bioactive Peptides, Cck8 Peptides, Chelating Agents, Gadolinium Complexes, Hydrophilic Heads, Hydrophobic Chains, Mixed Aggregates, Mixed Micelles, Molar Ratios, Phase Syntheses, Polymerization Processes, Relaxivity, Small-Angle Neutron Scatterings, Triple Bonds, Unimers, Uv Irradiations, Amphophile, Carbon, Cholecystokinin Octapeptide, Article, Chemical Bond, Chemical Structure, Contrast Enhancement, Controlled Study, Drug Structure, Fluorescence Analysis, Hydrophilicity, Nuclear Magnetic Resonance Imaging, Priority Journal, Solid Phase Synthesis, Ultraviolet Radiation,
Affiliations:
*** IBB - CNR ***
Dipartimento di Chimica-CSGI, Università degli Studi di Napoli Federico II, via Cinthia, 80126 Naples, Italy
Dipartimento di Scienze Biologiche-CIRPeB, Università degli Studi di Napoli Federico II, via Mezzocannone 16, 80134 Naples, Italy
Jülich Centre for Neutron Science, Forschungszentrum Jülich GmbH, Lichtenbergstrasse 1, 85747 Garching bei München, Germany
CSGI - Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, Florence, Italy
J lich Centre for Neutron Science, Forschungszentrum J lich GmbH, Lichtenbergstrasse 1, 85747 Garching bei M nchen, Germany
References:
Weissleder, R., Mahmood, U., Molecular imaging (2001) Radiology, 219, pp. 316-333. , Oak Brook, IL, United State
Aime, S., Cabella, C., Colombatto, S., Geninatti Crich, S., Gianolio, E., Maggioni, F., Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations (2002) J Magn Reson Imaging Field, 16, pp. 394-406
Aime, S., Fasano, M., Terreno, E., Botta, M., Protein-bound metal chelates (2001) Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, pp. 193-241. , In: Merbach A, Toth E (eds) Wiley, New York
Gao, J., Nasongkla, N., Khemtong, C., cRGD-encoded, MRI-visible polymeric micelles for tumor-targeted drug delivery (2007) Nanotechnology for Cancer Therapy, pp. 465-475. , In: Amiji M (ed) CRC, Boca Raton 1 plate
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor-specific contrast agents in MRI (2004) J Am Chem Soc, 126, pp. 3097-3107
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Teixeira, J., Schillen, K., Aime, S., Morelli, G., Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (2007) ChemBioChem, 8, pp. 950-955
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (2007) ChemPhysChem, 8, pp. 2526-2538
Evans, D.F., (1998) The Colloidal Domain: Where Physics, Chemistry, Biology, and Technology Meet, , 2nd edn. Wiley, New York
Zou, G., Fang, K., Xia, S., He, P., Elasticity of 10,12-pentacosadiynoic acid monolayer and the polymerized monolayer at varying pH and temperatures (2002) Langmuir, 18, pp. 6602-6605
Reubi, J.C., Schaer, J.-C., Waser, B., Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res, 57, pp. 1377-1386
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjug Chem, 10, pp. 137-140
Chan, W.C., White, P.D., (2000) Basic Procedures. Fmoc Solid Phase Peptide Synthesis, pp. 41-76. , Oxford University Press, Oxford
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci Field, 4, pp. 2411-2423
Birdi, K.S., Singh, H.N., Dalsager, S.U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalenesulfonate (1979) J Phys Chem, 83, pp. 2733-2737
De Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., A fluorimetric method for the estimation of the critical micelle concentration of surfactants (1981) Anal Biochem, 115, pp. 278-286
Lakowicz, J.R., (1983) Principles of Fluorescence Spectroscopy, , Springer, New York
Wignall, G.D., Bates, F.S., Absolute calibration of small-angle neutron scattering data (1987) J Appl Crystallogr, 20, pp. 28-40
Russell, T.P., Lin, J.S., Spooner, S., Wignall, G.D., Intercalibration of small-angle x-ray and neutron scattering data (1988) J Appl Crystallogr, 21, pp. 629-638
Shinoda, K., Nakagawa, T., Tamamushi, B., Isemura, T., (1962) Colloidal Surfactants, Some Physicochemical Properties, , Academy, New York
Caravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., Gadolinium(III) Chelates as MRI contrast agents: Structure, dynamics, and applications (1999) Chem Rev (Washington, D. C.), 99, pp. 2293-2352
Lipari, G., Szabo, A., Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity (1982) J Am Chem Soc, 104, pp. 4546-4559
Torres, S., Martins, J.A., Andre, J.P., Geraldes, C.F.G.C., Merbach, A.E., Toth, E., Supramolecular assembly of an amphiphilic GdIII chelate: Tuning the reorientational correlation time and the water exchange rate (2006) Chem-Eur J, 12, pp. 940-948
Nicolle, G.M., Toth, E., Eisenwiener, K.-P., Macke, H.R., Merbach, A.E., From monomers to micelles: Investigation of the parameters influencing proton relaxivity (2002) JBIC, J Biol Inorg Chem, 7, pp. 757-769
Nicolle, G.M., Tóth, É., Schmitt-Willich, H., Radchel, B., Merbach, A.E., The impact of rigidity and water exchange on the relaxivity of a dendritic MRI contrast agent (2002) Chem - Eur J, 8, pp. 1040-1048
Kotlarchyk, M., Chen, S.H., Analysis of small angle neutron scattering spectra from polydisperse interacting colloids (1983) J Chem Phys, 79, pp. 2461-2469
Evans, D. F., (1998) The Colloidal Domain: Where Physics, Chemistry, Biology, and Technology Meet, , 2nd edn. Wiley, New York
Reubi, J. C., Schaer, J. -C., Waser, B., Cholecystokinin (CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res, 57, pp. 1377-1386
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjug Chem, 10, pp. 137-140
Chan, W. C., White, P. D., (2000) Basic Procedures. Fmoc Solid Phase Peptide Synthesis, pp. 41-76. , Oxford University Press, Oxford
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci Field, 4, pp. 2411-2423
Birdi, K. S., Singh, H. N., Dalsager, S. U., Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalenesulfonate (1979) J Phys Chem, 83, pp. 2733-2737
Lakowicz, J. R., (1983) Principles of Fluorescence Spectroscopy, , Springer, New York
Wignall, G. D., Bates, F. S., Absolute calibration of small-angle neutron scattering data (1987) J Appl Crystallogr, 20, pp. 28-40
Russell, T. P., Lin, J. S., Spooner, S., Wignall, G. D., Intercalibration of small-angle x-ray and neutron scattering data (1988) J Appl Crystallogr, 21, pp. 629-638
Nicolle, G. M., Toth, E., Eisenwiener, K. -P., Macke, H. R., Merbach, A. E., From monomers to micelles: Investigation of the parameters influencing proton relaxivity (2002) JBIC, J Biol Inorg Chem, 7, pp. 757-769
Nicolle, G. M., T th, ., Schmitt-Willich, H., Radchel, B., Merbach, A. E., The impact of rigidity and water exchange on the relaxivity of a dendritic MRI contrast agent (2002) Chem - Eur J, 8, pp. 1040-1048
Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide
Two novel amphiphilic unimers containing an aliphatic hydrophobic chain (PDA) with two CΞC triple bonds and hydrophilic heads presenting the chelating agent DTPAGlu and the CCK8 bioactive peptide, respectively, have been prepared by solid phase synthesis. Aggregates obtained by mixing together PDA-DTPAGlu, or its Gd(III) complex, and PDA-L2-CCK8 in 70/30 molar ratio before and after a polymerization process carried out by UV irradiation have been structurally characterized by means of small angle neutron scattering. The relaxivity properties of aggregates containing Gadolinium complexes have also been investigated. Elongated mixed micelles have been observed, in which the relaxivity value r1p for each Gadolinium complex, measured at 20 MHz and 298 K, is around 12 mM-1 s-1. © Springer-Verlag 2008.
Two novel amphiphilic unimers containing an aliphatic hydrophobic chain (PDA) with two CΞC triple bonds and hydrophilic heads presenting the chelating agent DTPAGlu and the CCK8 bioactive peptide, respectively, have been prepared by solid phase synthesis. Aggregates obtained by mixing together PDA-DTPAGlu, or its Gd(III) complex, and PDA-L2-CCK8 in 70/30 molar ratio before and after a polymerization process carried out by UV irradiation have been structurally characterized by means of small angle neutron scattering. The relaxivity properties of aggregates containing Gadolinium complexes have also been investigated. Elongated mixed micelles have been observed, in which the relaxivity value r1p for each Gadolinium complex, measured at 20 MHz and 298 K, is around 12 mM-1 s-1. © Springer-Verlag 2008.
Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide
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Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide
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Impact Factor: 2.385
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
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Impact Factor: 4.383
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Pica A, Merlino A, Buell AK, Knowles TJ, Pizzo E, D'Alessio G, Sica F, Mazzarella L
* Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase (876 views)
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Impact Factor: 7.232
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
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Impact Factor: 1.862
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Hunger K, Buschhaus L, Biemann L, Braun M, Kovalenko S, Improta R, Kleinermanns K
* UV-light-induced hydrogen transfer in guanosine-guanosine aggregates (421 views)
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Impact Factor: 5.696
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (561 views)
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Impact Factor: 3.151
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Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (492 views)
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Impact Factor: 3.534
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
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Impact Factor: 1.799
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
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Impact Factor: 2.87
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (591 views)
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Impact Factor: 11.225
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
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Impact Factor: 3.415
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (431 views)
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Impact Factor: 1.807
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (528 views)
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Impact Factor: 4.869
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (361 views)
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Impact Factor: 2.02
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Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (626 views)
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Impact Factor: 2.648
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Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (258 views)
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Impact Factor: 1.654
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (391 views)
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Impact Factor: 3.15
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Randazzo R, Mammana A, D'Urso A, Lauceri R, Purrello R
* Reversible "chiral memory" in ruthenium tris(phenanthroline)- anionic porphyrin complexes (401 views)
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Impact Factor: 10.879
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (573 views)
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Impact Factor: 3.502
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
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Impact Factor: 3.446
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Attanasio F, Cascio C, Fisichella S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Trehalose effects on alpha-crystallin aggregates (529 views)
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Impact Factor: 2.749
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
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Impact Factor: 3.325
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
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Impact Factor: 3.902
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Roscigno P, D'Auria G, Falcigno L, D'Errico G, Paduano L
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Impact Factor: 3.705
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Angela M, Massimo De N, Rosaria L, Roberto P
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Impact Factor: 2.286
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
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Lauceria R, Purrellob R
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Impact Factor: 1.715
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (452 views)
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Impact Factor: 6.903
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
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Impact Factor: 3.834
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Moschetto A, Lauceri R, Gulino FG, Sciotto D, Purrello R
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Impact Factor: 6.201
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Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
* From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (668 views)
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Impact Factor: 9.023
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* The introduction of a cysteine residue modulates the mechanical properties of aromatic-based solid aggregates and self-supporting hydrogels (20 views)
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Impact Factor: 5.236
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Smaldone G, Caruso D, Sandomenico A, Iaccarino E, Focà A, Ruggiero A, Ruvo M, Vitagliano L
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Impact Factor:
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Monti A, Bruckmann C, Blasi F, Ruvo M, Vitagliano L, Doti N
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Impact Factor: 5.996
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Balasco N, Diaferia C, Morelli G, Vitagliano L, Accardo A
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Impact Factor: 5.48
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Marasco D, Vicidomini C, Krupa P, Cioffi F, Pham DQH, Li MS, Florio D, Broersen K, De Pandis MF, Roviello GN
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Impact Factor: 5.192
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Di Natale C, La Manna S, Avitabile C, Florio D, Morelli G, Netti PA, Marasco D
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Impact Factor: 3.119
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Di Natale C, La Manna S, Avitabile C, Florio D, Morelli G, Netti PA, Marasco D
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Impact Factor: 4.831
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Avitabile C, Diaferia C, Roviello V, Altamura D, Giannini C, Vitagliano L, Accardo A, Romanelli A
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Impact Factor: 5.476
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Balasco N, Barone D, Iaccarino E, Sandomenico A, De Simone A, Ruvo M, Vitagliano L
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Impact Factor: 1.427
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Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
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Impact Factor: 5.476
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (197 views)
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Galati C, Spinella N, Renna L, Milardi D, Attanasio F, Sciacca MFM, Bongiorno C
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Impact Factor: 2.968
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Grasso GI, Bellia F, Arena G, Satriano C, Vecchio G, Rizzarelli E
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Impact Factor: 4.816
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Di Natale C, Scognamiglio PL, Cascella R, Cecchi C, Russo A, Leone M, Penco A, Relini A, Federici L, Di Matteo A, Chiti F, Vitagliano L, Marasco D
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
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Impact Factor: 2.963
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Sinopoli A, Magri A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, GrassoG
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Impact Factor: 3.585
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
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Impact Factor: 1.865
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Accardo A, Ringhieri P, Palumbo R, Morelli G
* Influence of PEG length on conformational and binding properties of CCK peptides exposed by supramolecular aggregates (394 views)
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Impact Factor: 2.385
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (570 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Pica A, Merlino A, Buell AK, Knowles TJ, Pizzo E, D'Alessio G, Sica F, Mazzarella L
* Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase (876 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Oct; 69: 2116-2123.
Impact Factor: 7.232
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (407 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Hunger K, Buschhaus L, Biemann L, Braun M, Kovalenko S, Improta R, Kleinermanns K
* UV-light-induced hydrogen transfer in guanosine-guanosine aggregates (421 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Apr; 19(17): 5425-5431.
Impact Factor: 5.696
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (561 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (492 views)
Mol Biosyst (ISSN: 1742-206x), 2011 Mar; 7(3): 862-870.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
View Export to BibTeX Export to EndNote
Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (591 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (431 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (528 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (361 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
View Export to BibTeX Export to EndNote
Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (626 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
Impact Factor: 2.648
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (258 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (391 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
View Export to BibTeX Export to EndNote
Randazzo R, Mammana A, D'Urso A, Lauceri R, Purrello R
* Reversible "chiral memory" in ruthenium tris(phenanthroline)- anionic porphyrin complexes (401 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2008; 47(51): 9879-9882.
Impact Factor: 10.879
View Export to BibTeX Export to EndNote
Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (573 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
View Export to BibTeX Export to EndNote
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
View Export to BibTeX Export to EndNote
Attanasio F, Cascio C, Fisichella S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Trehalose effects on alpha-crystallin aggregates (529 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 0006-291xlinking), 2007 Mar 23; 354(4): 899-905.
Impact Factor: 2.749
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (441 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Roscigno P, D'Auria G, Falcigno L, D'Errico G, Paduano L
* Effect of the addition of a nonionic surfactant on the complex poly(asparagine)-cationic surfactant (360 views)
Langmuir (ISSN: 0743-7463), 2005 Sep 30; 21(18): 8123-8130.
Impact Factor: 3.705
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Angela M, Massimo De N, Rosaria L, Roberto P
* Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (417 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
Impact Factor: 2.286
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Lauceria R, Purrellob R
* Transfer, memory and amplification of chirality in porphyrin aggregates (303 views)
Supramol Chem (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
Impact Factor: 1.715
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (452 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Moschetto A, Lauceri R, Gulino FG, Sciotto D, Purrello R
* Non-covalent synthesis in aqueous solution of discrete multi-porphyrin aggregates with programmable stoichiometry and sequence (490 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Dec 11; 124(49): 14536-14537.
Impact Factor: 6.201
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Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
* From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (668 views)
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
Impact Factor: 9.023
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48 Records (46 excluding Abstracts).
Total impact factor: 188.643 (186.989 excluding Abstracts).
Total 5 year impact factor: 200.342 (198.56 excluding Abstracts).
Total impact factor: 188.643 (186.989 excluding Abstracts).
Total 5 year impact factor: 200.342 (198.56 excluding Abstracts).
423 views. Last view on Monday 13 March 2023, 11:17:32
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