In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides(480 views) Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
Keywords: Angiogenesis, Chorioallantoic Membrane, Conformational Studies, Huvec, Peptides, Thymosin-β4, Thymosin Beta4, Amino Acid Sequence, Amino Terminal Sequence, Apoptosis, Article, Binding Site, Carboxy Terminal Sequence, Cell Death, Cell Proliferation, Circular Dichroism, Controlled Study, Human, Human Cell, In Vitro Study, In Vivo Study, Morphogenesis, Nonhuman, Peptide Synthesis, Priority Journal, Proton Nuclear Magnetic Resonance, Signal Transduction, Umbilical Vein Endothelial Cell, Angiogenesis Inducing Agents, Animals, Chick Embryo, Human Umbilical Vein Endothelial Cells, Models, Molecular, Molecular Sequence Data, Neovascularization, Physiologic, Peptide Fragments, Protein Conformation, Wound Healing, Angiogenesis Inducing Agents Chemistry Pharmacology, Cell Proliferation Drug Effects, In Vitro Techniques, Physiologic Drug Effects Physiology, Peptide Fragments Chemical Synthesis Chemistry Genetics Pharmacology, Signal Transduction Drug Effects, Thymosin Chemistry Genetics Pharmacology Physiology, Wound Healing Drug Effects Physiology,
Affiliations: *** IBB - CNR ***
Department of Chemical Process Engineering, University of Padua, via Marzolo 9, 35131 Padua, Italy
Department of Pharmaceutical Sciences, University of Padua, via Marzolo 5, 35131 Padua, Italy
Department of Human Anatomy and Physiology, University of Padua, via Gabelli 65, 35121 Padua, Italy
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Dedova, I. V., Nikolaeva, O. P., Safer, D., De La Cruz, E. M., Remedios, C. G., Thymosin beta 4 induces a conformational change in actin monomers (2006) Biophys. J., 90, pp. 985-992
Sch bitz, B., Netzker, R., Hannappel, E., Brand, K., Cell-cycle-regulated expression of thymosin- 4 in thymocytes (2001) Eur. J. Biochem., 199, pp. 257-262
Troys, M. V., Defitte, D., Goethals, M., Carlier, M. F., Vandekerckhove, J., Ampe, C., The actin binding site of thymosin 4 mapped by mutational analysis (1996) EMBO J., 15, pp. 201-210
Zoubek, R. E., Hannappel, E., Subcellular distribution of thymosin beta4 (2007) Ann. N. Y. Acad. Sci. USA, 1112, pp. 442-450
Malinda, K. M., Sidhu, G. S., Mani, H., Banaudha, K., Maheshwari, R. K., Goldstein, A. L., Thymosin 4 accelerates wound healing (1999) J. Invest. Dermatol., 113, pp. 364-368
Malinda, K. M., Goldstein, A. L., Kleinman, H. K., Thymosin 4 stimulates directional migration of human umbilical vein endothelial cells (1997) FASEB J., 11, pp. 474-481
Huff, T., Otto, A. M., Muller, C. S., Meier, M., Hannappel, E., Thymosin 4 is released from human blood platelets and attached by factor XIIIa (transglutaminase) to fibrin and collagen (2002) FASEB J., 16, pp. 691-696
Bax, A., Davis, D. G., MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy (1985) J. Magn. Res., 65, pp. 355-360
States, D. J., Haberkoern, R. A., Ruben, D. J., A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants (1982) J. Magn. Res., 48, pp. 286-292
Johnson, B. A., Using NMR view to visualize and analyze the NMR spectra of macromolecules (2004) Methods Mol. Biol., 278, pp. 313-352
Wishart, D. S., Sykes, B. D., Richards, F. M., Relationship between nuclear magnetic resonance chemical shift and protein secondary structure (1991) J. Mol. Biol., 222, pp. 311-333
Goldstein, A. L., Hannappel, E., Kleinman, H. K., Thymosin- 4: actin-sequestering protein moonlights to repair injured tissues (2005) Trends Mol. Med., 11, pp. 422-429
Grant, D. S., Kinsella, J. L., Kibbey, M. C., La Flamme, S., Burbero, P. D., Goldstein, A. L., Matrigel induces thymosin 4 gene in differentiating endothelial cells (1995) J. Cell Sci., 106, pp. 3685-3694
Wang, W. S., Chen, P. M., Hsiao, H. L., Ju, S. Y., Su, Y., Overexpression of the thymosin- 4 gene is associated with malignant progression of SW480 colon cancer cell (2003) Oncogene, 22, pp. 3297-3306
Henry, T. D., Abraham, J. A., Review of preclinical and clinical results with vascular endothelial growth factors for therapeutic angiogenesis (2000) Curr. Inter. Cardiol. Rep., 2, pp. 228-241
In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides
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