Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (459 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.115, 5-year impact factor: 5.504
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33845352894&partnerID=40&md5=1f615af91d14f93ebb6e0e81bdcf97eb
Keywords: 2 Dipropylamino 8 Hydroxy 1 Methyltetralin, Alanine, Epidermal Growth Factor, Histidine, Membrane Protein, Mutant Protein, Protein Cripto, Tryptophan, Article, Cell Membrane, Disulfide Bond, Hydrophilicity, Hydrophobicity, Molecular Recognition, Mouse, Nonhuman, Point Mutation, Protein Domain, Protein Structure, Receptor Binding, Amino Acid Sequence, Animals, Magnetic Resonance Spectroscopy, Membrane Glycoproteins, Models, Molecular Sequence Data, Neoplasm Proteins, Protein Conformation, Tertiary, Solutions, Epidermal Growth Factor Chemistry Genetics, Membrane Glycoproteins Chemistry Genetics, Neoplasm Proteins Chemistry Genetics,
Affiliations:
*** IBB - CNR ***
Dipartimento di Chimica, Università Federico II, Complesso Universitario MSA, via Cintia 45, 80126 Napoli, Italy
Istituto di Biostrutture e Bioimmagini del CNR, via Mezzocannone, 16, 80134 Napoli, Italy
Istituto di Genetica e Biofisica Adriano B. Traverso del CNR, via P. Castellino, 111, 80126 Napoli, Italy
References:
Adkins, H.B., Bianco, C., Schiffer, S.G., Rayhorn, P., Zafari, M., Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo (2003) J. Clin. Invest., 112, pp. 575-58
Xing, P.X., Hu, X.F., Pietersz, G.A., Hosick, H.L., McKenzie, I.F., Cripto: A novel target for antibody-based cancer immunotherapy (2004) Cancer Res., 64, pp. 4018-4023
Bianco, C., Strizzi, L., Normanno, N., Khan, N., Salomon, D.S., Cripto-1: An oncofetal gene with many faces (2005) Curr. Top. Dev. Biol., 67, pp. 85-133
Hu, X.F., Xing, P.X., Cripto as a target for cancer immunotherapy (2005) Expert Opin. Ther. Targets, 9, pp. 383-394
Niemeyer, C.C., Persico, M.G., Adamson, E.D., Cripto: Roles in mammary cell growth, survival, differentiation and transformation (1998) Cell Death Differ., 5, pp. 440-449
Xu, C., Liguori, G., Persico, M.G., Adamson, E.D., Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes (1999) Development, 126, pp. 483-494
Salomon, D.S., Bianco, C., Ebert, A.D., Khan, N.I., De Santis, M., The EGF-CFC family: Novel epidermal growth factor-related proteins in development and cancer (2000) Endocr.-Relat. Cancer, 7, pp. 199-226
Sun, Y., Strizzi, L., Raafat, A., Hirota, M., Bianco, C., Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis (2005) Am. J. Pathol., 167, pp. 585-597
Wechselberger, C., Strizzi, L., Kenney, N., Hirota, M., Sun, Y., Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma (2005) Oncogene, 24, pp. 4094-4105
Minchiotti, G., Parisi, S., Liguori, G.L., D'Andrea, D., Persico, M.G., Role of the EGF-CFC gene cripto in cell differentiation and embryo development (2002) Gene, 287, pp. 33-37
Sonntag, K.C., Simantov, R., Bjorklund, L., Cooper, O., Pruszak, J., Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells (2005) Mol. Cell Neurosci., 28, pp. 417-429
Kenney, N.J., Adkins, H.B., Sanicola, M., Nodal and Cripto-1: Embryonic pattern formation genes involved in mammary gland development and tumorigenesis (2004) J. Mammary Gland Biol. Neoplasia, 9, pp. 133-144
Adamson, E.D., Minchiotti, G., Salomon, D.S., Cripto: A tumor growth factor and more (2002) J. Cell. Physiol., 190, pp. 267-278
Parisi, S., D'Andrea, D., Lago, C.T., Adamson, E.D., Persico, M.G., Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells (2003) J. Cell Biol., 163, pp. 303-314
Gerecht-Nir, S., Dazard, J.E., Golan-Mashiach, M., Osenberg, S., Botvinnik, A., Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells (2005) Dev. Dyn., 232, pp. 487-497
Li, Y., Powell, S., Brunette, E., Lebkowski, J., Mandalam, R., Expansion of human embryonic stem cells in defined serum-free medium devoid of animal-derived products (2005) Biotechnol. Bioeng., 91, pp. 688-698
Liu, H., Harris, T.M., Kim, H.H., Childs, G., Cardiac myocyte differentiation: The Nkx2.5 and Cripto target genes in P19 clone 6 cells (2005) Funct. Integr. Genomics, 5, pp. 218-239
Minchiotti, G., Nodal-dependant Cripto signaling in ES cells: From stem cells to tumor biology (2005) Oncogene, 24, pp. 5668-5675
Sakuma, R., Ohnishi Yi, Y., Meno, C., Fujii, H., Juan, H., Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion (2002) Genes Cells, 7, pp. 401-412
Yan, Y.T., Liu, J.J., Luo, Y., C., E., Haltiwanger, R.S., Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway (2002) Mol. Cell Biol., 22, pp. 4439-4449
Yeo, C., Whitman, M., Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms (2001) Mol. Cell, 7, pp. 949-957
Schier, A.F., Nodal signaling in vertebrate development (2003) Annu. Rev. Cell Dev. Biol., 19, pp. 589-621
Chen, C., Ware, S.M., Sato, A., Houston-Hawkins, D.E., Habas, R., The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo (2006) Development, 133, pp. 319-329
Cheng, S.K., Olale, F., Bennett, J.T., Brivanlou, A.H., Schier, A.F., EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1 (2003) Genes Dev., 17, pp. 31-36
Gray, P.C., Harrison, C.A., Vale, W., Cripto forms a complex with activin and type II activin receptors and can block activin signaling (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 5193-5198
Lohmeyer, M., Harrison, P.M., Kannan, S., Desantis, M., O'Reilly, N.J., Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human cripto (1997) Biochemistry, 36, pp. 3837-3845
Foley, S.F., Van Vlijmen, H.W., Boynton, R.E., Adkins, H.B., Cheung, A.E., The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis (2003) Eur. J. Biochem., 270, pp. 3610-3618
Marasco, D., Saporito, A., Ponticelli, S., Chambery, A., De Falco, S., Chemical synthesis of mouse cripto CFC variants (2006) Proteins, 64, pp. 779-788
Risbridger, G.P., Schmitt, J.F., Robertson, D.M., Activins and inhibins in endocrine and other tumors (2001) Endocr. Rev., 22, pp. 836-858
Shen, M.M., Decrypting the role of Cripto in tumorigenesis (2003) J. Clin. Invest., 112, pp. 500-502
Bianco, C., Normanno, N., Salomon, D.S., Ciardiello, F., Role of the cripto (EGF-CFC) family in embryogenesis and cancer (2004) Growth Factors, 22, pp. 133-139
Shen, M.M., Schier, A.F., The EGF-CFC gene family in vertebrate development (2000) Trends Genet., 16, pp. 303-309
Persico, M.G., Liguori, G.L., Parisi, S., D'Andrea, D., Salomon, D.S., Cripto in tumors and embryo development (2001) Biochim. Biophys. Acta, 1552, pp. 87-93
Wishart, D.S., Sykes, B.D., Richards, F.M., Relationship between nuclear magnetic resonance chemical shift and protein secondary structure (1991) J. Mol. Biol., 222, pp. 311-333
Guntert, P., Mumenthaler, C., Wuthrich, K., Torsion angle dynamics for NMR structure calculation with the new program DYANA (1997) J. Mol. Biol., 273, pp. 283-298
Harrison, P.M., Sternberg, M.J.E., The disulphide beta-cross: From cystine geometry and clustering to classification of small disulphide-rich protein folds (1996) J. Mol. Biol., 264, pp. 603-623
Shi, S., Stanley, P., Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 5234-5239
Schiffer, S.G., Foley, S., Kaffashan, A., Hronowski, X., Zichittella, A.E., Fucosylation of Cripto is required for its ability to facilitate nodal signaling (2001) J. Biol. Chem., 276, pp. 37769-37778
Bax, A., Davis, D.G., MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy (1985) J. Magn. Res., 65, pp. 355-360
Bax, A., Practical aspects of two-dimensional transverse NOE spectroscopy (1985) J. Magn. Res., 63, pp. 207-213
Piantini, U., Sorensen, O.W., Ernst, R.R., Multiple quantum filters for elucidating NMR coupling networks (1982) J. Am. Chem. Soc., 104, pp. 6800-6801
States, D.J., Haberhorn, R.A., Ruben, D.J., A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants (1982) J. Magn. Res., 48, pp. 286-292
Piotto, M., Saudek, V., Skelnar, V.J., Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions (1992) J. Biomol. NMR, 2, pp. 661-665
Delaglio, F., Grzesiek, S., Vuister, G.W., Zhu, G., Pfeifer, J., NMRPipe: A multidimensional spectral processing system based on UNIX pipes (1995) J. Biomol. NMR, 6, pp. 277-293
Johnson, B.A., Blevins, R.A., NMRView: A computer program for the visualization and analysis of NMR data (1994) J. Biomol. NMR, 4, pp. 603-614
Wuthrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley: New York
Guntert, P., Braun, W., Wuthrich, K., Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS, and GLOMSA (1991) J. Mol. Biol., 217, pp. 517-530
Karplus, M., Vicinal proton coupling in nuclear magnetic resonance (1963) J. Am. Chem. Soc., 85, pp. 2870-2871
Guntert, P., Wuthrich, K., Improved efficiency of protein structure calculations from NMR data using the program DIANA with redundant dihedral angle constraints (1991) J. Biomol. NMR, 1, pp. 447-456
Case, D.A., Pearlman, D.A., Caldwell, J.W., Cheatham, I.T.E., Ross, W.S., (1999) AMBER 6, , University of California: San Francisco, CA
Pearlman, D.A., Case, D.A., Caldwell, J.W., Ross, W.S., Cheatham, I.T.E., AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to stimulate the structural and energetic properties of molecules (1996) Proteins, 26, pp. 304-313
Weiner, S.J., Kollmann, P.A., Nguyen, D.T., Case, D.A., An all atom force field for simulations of proteins and nucleic acids (1986) J. Comput. Chem., 7, pp. 230-238
Koradi, R., Billeter, M., Wuthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graphics Modell., 14, pp. 51-55
Adkins, H. B., Bianco, C., Schiffer, S. G., Rayhorn, P., Zafari, M., Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo (2003) J. Clin. Invest., 112, pp. 575-58
Xing, P. X., Hu, X. F., Pietersz, G. A., Hosick, H. L., McKenzie, I. F., Cripto: A novel target for antibody-based cancer immunotherapy (2004) Cancer Res., 64, pp. 4018-4023
Hu, X. F., Xing, P. X., Cripto as a target for cancer immunotherapy (2005) Expert Opin. Ther. Targets, 9, pp. 383-394
Niemeyer, C. C., Persico, M. G., Adamson, E. D., Cripto: Roles in mammary cell growth, survival, differentiation and transformation (1998) Cell Death Differ., 5, pp. 440-449
Salomon, D. S., Bianco, C., Ebert, A. D., Khan, N. I., De Santis, M., The EGF-CFC family: Novel epidermal growth factor-related proteins in development and cancer (2000) Endocr. -Relat. Cancer, 7, pp. 199-226
Sonntag, K. C., Simantov, R., Bjorklund, L., Cooper, O., Pruszak, J., Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells (2005) Mol. Cell Neurosci., 28, pp. 417-429
Kenney, N. J., Adkins, H. B., Sanicola, M., Nodal and Cripto-1: Embryonic pattern formation genes involved in mammary gland development and tumorigenesis (2004) J. Mammary Gland Biol. Neoplasia, 9, pp. 133-144
Adamson, E. D., Minchiotti, G., Salomon, D. S., Cripto: A tumor growth factor and more (2002) J. Cell. Physiol., 190, pp. 267-278
Yan, Y. T., Liu, J. J., Luo, Y., C., E., Haltiwanger, R. S., Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway (2002) Mol. Cell Biol., 22, pp. 4439-4449
Schier, A. F., Nodal signaling in vertebrate development (2003) Annu. Rev. Cell Dev. Biol., 19, pp. 589-621
Chen, C., Ware, S. M., Sato, A., Houston-Hawkins, D. E., Habas, R., The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo (2006) Development, 133, pp. 319-329
Cheng, S. K., Olale, F., Bennett, J. T., Brivanlou, A. H., Schier, A. F., EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1 (2003) Genes Dev., 17, pp. 31-36
Gray, P. C., Harrison, C. A., Vale, W., Cripto forms a complex with activin and type II activin receptors and can block activin signaling (2003) Proc. Natl. Acad. Sci. U. S. A., 100, pp. 5193-5198
Foley, S. F., Van Vlijmen, H. W., Boynton, R. E., Adkins, H. B., Cheung, A. E., The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis (2003) Eur. J. Biochem., 270, pp. 3610-3618
Risbridger, G. P., Schmitt, J. F., Robertson, D. M., Activins and inhibins in endocrine and other tumors (2001) Endocr. Rev., 22, pp. 836-858
Shen, M. M., Decrypting the role of Cripto in tumorigenesis (2003) J. Clin. Invest., 112, pp. 500-502
Shen, M. M., Schier, A. F., The EGF-CFC gene family in vertebrate development (2000) Trends Genet., 16, pp. 303-309
Persico, M. G., Liguori, G. L., Parisi, S., D'Andrea, D., Salomon, D. S., Cripto in tumors and embryo development (2001) Biochim. Biophys. Acta, 1552, pp. 87-93
Wishart, D. S., Sykes, B. D., Richards, F. M., Relationship between nuclear magnetic resonance chemical shift and protein secondary structure (1991) J. Mol. Biol., 222, pp. 311-333
Harrison, P. M., Sternberg, M. J. E., The disulphide beta-cross: From cystine geometry and clustering to classification of small disulphide-rich protein folds (1996) J. Mol. Biol., 264, pp. 603-623
Schiffer, S. G., Foley, S., Kaffashan, A., Hronowski, X., Zichittella, A. E., Fucosylation of Cripto is required for its ability to facilitate nodal signaling (2001) J. Biol. Chem., 276, pp. 37769-37778
Bax, A., Davis, D. G., MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy (1985) J. Magn. Res., 65, pp. 355-360
States, D. J., Haberhorn, R. A., Ruben, D. J., A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants (1982) J. Magn. Res., 48, pp. 286-292
Johnson, B. A., Blevins, R. A., NMRView: A computer program for the visualization and analysis of NMR data (1994) J. Biomol. NMR, 4, pp. 603-614
Case, D. A., Pearlman, D. A., Caldwell, J. W., Cheatham, I. T. E., Ross, W. S., (1999) AMBER 6, , University of California: San Francisco, CA
Pearlman, D. A., Case, D. A., Caldwell, J. W., Ross, W. S., Cheatham, I. T. E., AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to stimulate the structural and energetic properties of molecules (1996) Proteins, 26, pp. 304-313
Weiner, S. J., Kollmann, P. A., Nguyen, D. T., Case, D. A., An all atom force field for simulations of proteins and nucleic acids (1986) J. Comput. Chem., 7, pp. 230-238
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.115, 5-year impact factor: 5.504
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33845352894&partnerID=40&md5=1f615af91d14f93ebb6e0e81bdcf97eb
Keywords: 2 Dipropylamino 8 Hydroxy 1 Methyltetralin, Alanine, Epidermal Growth Factor, Histidine, Membrane Protein, Mutant Protein, Protein Cripto, Tryptophan, Article, Cell Membrane, Disulfide Bond, Hydrophilicity, Hydrophobicity, Molecular Recognition, Mouse, Nonhuman, Point Mutation, Protein Domain, Protein Structure, Receptor Binding, Amino Acid Sequence, Animals, Magnetic Resonance Spectroscopy, Membrane Glycoproteins, Models, Molecular Sequence Data, Neoplasm Proteins, Protein Conformation, Tertiary, Solutions, Epidermal Growth Factor Chemistry Genetics, Membrane Glycoproteins Chemistry Genetics, Neoplasm Proteins Chemistry Genetics,
Affiliations:
*** IBB - CNR ***
Dipartimento di Chimica, Università Federico II, Complesso Universitario MSA, via Cintia 45, 80126 Napoli, Italy
Istituto di Biostrutture e Bioimmagini del CNR, via Mezzocannone, 16, 80134 Napoli, Italy
Istituto di Genetica e Biofisica Adriano B. Traverso del CNR, via P. Castellino, 111, 80126 Napoli, Italy
References:
Adkins, H.B., Bianco, C., Schiffer, S.G., Rayhorn, P., Zafari, M., Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo (2003) J. Clin. Invest., 112, pp. 575-58
Xing, P.X., Hu, X.F., Pietersz, G.A., Hosick, H.L., McKenzie, I.F., Cripto: A novel target for antibody-based cancer immunotherapy (2004) Cancer Res., 64, pp. 4018-4023
Bianco, C., Strizzi, L., Normanno, N., Khan, N., Salomon, D.S., Cripto-1: An oncofetal gene with many faces (2005) Curr. Top. Dev. Biol., 67, pp. 85-133
Hu, X.F., Xing, P.X., Cripto as a target for cancer immunotherapy (2005) Expert Opin. Ther. Targets, 9, pp. 383-394
Niemeyer, C.C., Persico, M.G., Adamson, E.D., Cripto: Roles in mammary cell growth, survival, differentiation and transformation (1998) Cell Death Differ., 5, pp. 440-449
Xu, C., Liguori, G., Persico, M.G., Adamson, E.D., Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes (1999) Development, 126, pp. 483-494
Salomon, D.S., Bianco, C., Ebert, A.D., Khan, N.I., De Santis, M., The EGF-CFC family: Novel epidermal growth factor-related proteins in development and cancer (2000) Endocr.-Relat. Cancer, 7, pp. 199-226
Sun, Y., Strizzi, L., Raafat, A., Hirota, M., Bianco, C., Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis (2005) Am. J. Pathol., 167, pp. 585-597
Wechselberger, C., Strizzi, L., Kenney, N., Hirota, M., Sun, Y., Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma (2005) Oncogene, 24, pp. 4094-4105
Minchiotti, G., Parisi, S., Liguori, G.L., D'Andrea, D., Persico, M.G., Role of the EGF-CFC gene cripto in cell differentiation and embryo development (2002) Gene, 287, pp. 33-37
Sonntag, K.C., Simantov, R., Bjorklund, L., Cooper, O., Pruszak, J., Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells (2005) Mol. Cell Neurosci., 28, pp. 417-429
Kenney, N.J., Adkins, H.B., Sanicola, M., Nodal and Cripto-1: Embryonic pattern formation genes involved in mammary gland development and tumorigenesis (2004) J. Mammary Gland Biol. Neoplasia, 9, pp. 133-144
Adamson, E.D., Minchiotti, G., Salomon, D.S., Cripto: A tumor growth factor and more (2002) J. Cell. Physiol., 190, pp. 267-278
Parisi, S., D'Andrea, D., Lago, C.T., Adamson, E.D., Persico, M.G., Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells (2003) J. Cell Biol., 163, pp. 303-314
Gerecht-Nir, S., Dazard, J.E., Golan-Mashiach, M., Osenberg, S., Botvinnik, A., Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells (2005) Dev. Dyn., 232, pp. 487-497
Li, Y., Powell, S., Brunette, E., Lebkowski, J., Mandalam, R., Expansion of human embryonic stem cells in defined serum-free medium devoid of animal-derived products (2005) Biotechnol. Bioeng., 91, pp. 688-698
Liu, H., Harris, T.M., Kim, H.H., Childs, G., Cardiac myocyte differentiation: The Nkx2.5 and Cripto target genes in P19 clone 6 cells (2005) Funct. Integr. Genomics, 5, pp. 218-239
Minchiotti, G., Nodal-dependant Cripto signaling in ES cells: From stem cells to tumor biology (2005) Oncogene, 24, pp. 5668-5675
Sakuma, R., Ohnishi Yi, Y., Meno, C., Fujii, H., Juan, H., Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion (2002) Genes Cells, 7, pp. 401-412
Yan, Y.T., Liu, J.J., Luo, Y., C., E., Haltiwanger, R.S., Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway (2002) Mol. Cell Biol., 22, pp. 4439-4449
Yeo, C., Whitman, M., Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms (2001) Mol. Cell, 7, pp. 949-957
Schier, A.F., Nodal signaling in vertebrate development (2003) Annu. Rev. Cell Dev. Biol., 19, pp. 589-621
Chen, C., Ware, S.M., Sato, A., Houston-Hawkins, D.E., Habas, R., The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo (2006) Development, 133, pp. 319-329
Cheng, S.K., Olale, F., Bennett, J.T., Brivanlou, A.H., Schier, A.F., EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1 (2003) Genes Dev., 17, pp. 31-36
Gray, P.C., Harrison, C.A., Vale, W., Cripto forms a complex with activin and type II activin receptors and can block activin signaling (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 5193-5198
Lohmeyer, M., Harrison, P.M., Kannan, S., Desantis, M., O'Reilly, N.J., Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human cripto (1997) Biochemistry, 36, pp. 3837-3845
Foley, S.F., Van Vlijmen, H.W., Boynton, R.E., Adkins, H.B., Cheung, A.E., The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis (2003) Eur. J. Biochem., 270, pp. 3610-3618
Marasco, D., Saporito, A., Ponticelli, S., Chambery, A., De Falco, S., Chemical synthesis of mouse cripto CFC variants (2006) Proteins, 64, pp. 779-788
Risbridger, G.P., Schmitt, J.F., Robertson, D.M., Activins and inhibins in endocrine and other tumors (2001) Endocr. Rev., 22, pp. 836-858
Shen, M.M., Decrypting the role of Cripto in tumorigenesis (2003) J. Clin. Invest., 112, pp. 500-502
Bianco, C., Normanno, N., Salomon, D.S., Ciardiello, F., Role of the cripto (EGF-CFC) family in embryogenesis and cancer (2004) Growth Factors, 22, pp. 133-139
Shen, M.M., Schier, A.F., The EGF-CFC gene family in vertebrate development (2000) Trends Genet., 16, pp. 303-309
Persico, M.G., Liguori, G.L., Parisi, S., D'Andrea, D., Salomon, D.S., Cripto in tumors and embryo development (2001) Biochim. Biophys. Acta, 1552, pp. 87-93
Wishart, D.S., Sykes, B.D., Richards, F.M., Relationship between nuclear magnetic resonance chemical shift and protein secondary structure (1991) J. Mol. Biol., 222, pp. 311-333
Guntert, P., Mumenthaler, C., Wuthrich, K., Torsion angle dynamics for NMR structure calculation with the new program DYANA (1997) J. Mol. Biol., 273, pp. 283-298
Harrison, P.M., Sternberg, M.J.E., The disulphide beta-cross: From cystine geometry and clustering to classification of small disulphide-rich protein folds (1996) J. Mol. Biol., 264, pp. 603-623
Shi, S., Stanley, P., Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 5234-5239
Schiffer, S.G., Foley, S., Kaffashan, A., Hronowski, X., Zichittella, A.E., Fucosylation of Cripto is required for its ability to facilitate nodal signaling (2001) J. Biol. Chem., 276, pp. 37769-37778
Bax, A., Davis, D.G., MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy (1985) J. Magn. Res., 65, pp. 355-360
Bax, A., Practical aspects of two-dimensional transverse NOE spectroscopy (1985) J. Magn. Res., 63, pp. 207-213
Piantini, U., Sorensen, O.W., Ernst, R.R., Multiple quantum filters for elucidating NMR coupling networks (1982) J. Am. Chem. Soc., 104, pp. 6800-6801
States, D.J., Haberhorn, R.A., Ruben, D.J., A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants (1982) J. Magn. Res., 48, pp. 286-292
Piotto, M., Saudek, V., Skelnar, V.J., Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions (1992) J. Biomol. NMR, 2, pp. 661-665
Delaglio, F., Grzesiek, S., Vuister, G.W., Zhu, G., Pfeifer, J., NMRPipe: A multidimensional spectral processing system based on UNIX pipes (1995) J. Biomol. NMR, 6, pp. 277-293
Johnson, B.A., Blevins, R.A., NMRView: A computer program for the visualization and analysis of NMR data (1994) J. Biomol. NMR, 4, pp. 603-614
Wuthrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley: New York
Guntert, P., Braun, W., Wuthrich, K., Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS, and GLOMSA (1991) J. Mol. Biol., 217, pp. 517-530
Karplus, M., Vicinal proton coupling in nuclear magnetic resonance (1963) J. Am. Chem. Soc., 85, pp. 2870-2871
Guntert, P., Wuthrich, K., Improved efficiency of protein structure calculations from NMR data using the program DIANA with redundant dihedral angle constraints (1991) J. Biomol. NMR, 1, pp. 447-456
Case, D.A., Pearlman, D.A., Caldwell, J.W., Cheatham, I.T.E., Ross, W.S., (1999) AMBER 6, , University of California: San Francisco, CA
Pearlman, D.A., Case, D.A., Caldwell, J.W., Ross, W.S., Cheatham, I.T.E., AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to stimulate the structural and energetic properties of molecules (1996) Proteins, 26, pp. 304-313
Weiner, S.J., Kollmann, P.A., Nguyen, D.T., Case, D.A., An all atom force field for simulations of proteins and nucleic acids (1986) J. Comput. Chem., 7, pp. 230-238
Koradi, R., Billeter, M., Wuthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graphics Modell., 14, pp. 51-55
Adkins, H. B., Bianco, C., Schiffer, S. G., Rayhorn, P., Zafari, M., Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo (2003) J. Clin. Invest., 112, pp. 575-58
Xing, P. X., Hu, X. F., Pietersz, G. A., Hosick, H. L., McKenzie, I. F., Cripto: A novel target for antibody-based cancer immunotherapy (2004) Cancer Res., 64, pp. 4018-4023
Hu, X. F., Xing, P. X., Cripto as a target for cancer immunotherapy (2005) Expert Opin. Ther. Targets, 9, pp. 383-394
Niemeyer, C. C., Persico, M. G., Adamson, E. D., Cripto: Roles in mammary cell growth, survival, differentiation and transformation (1998) Cell Death Differ., 5, pp. 440-449
Salomon, D. S., Bianco, C., Ebert, A. D., Khan, N. I., De Santis, M., The EGF-CFC family: Novel epidermal growth factor-related proteins in development and cancer (2000) Endocr. -Relat. Cancer, 7, pp. 199-226
Sonntag, K. C., Simantov, R., Bjorklund, L., Cooper, O., Pruszak, J., Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells (2005) Mol. Cell Neurosci., 28, pp. 417-429
Kenney, N. J., Adkins, H. B., Sanicola, M., Nodal and Cripto-1: Embryonic pattern formation genes involved in mammary gland development and tumorigenesis (2004) J. Mammary Gland Biol. Neoplasia, 9, pp. 133-144
Adamson, E. D., Minchiotti, G., Salomon, D. S., Cripto: A tumor growth factor and more (2002) J. Cell. Physiol., 190, pp. 267-278
Yan, Y. T., Liu, J. J., Luo, Y., C., E., Haltiwanger, R. S., Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway (2002) Mol. Cell Biol., 22, pp. 4439-4449
Schier, A. F., Nodal signaling in vertebrate development (2003) Annu. Rev. Cell Dev. Biol., 19, pp. 589-621
Chen, C., Ware, S. M., Sato, A., Houston-Hawkins, D. E., Habas, R., The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo (2006) Development, 133, pp. 319-329
Cheng, S. K., Olale, F., Bennett, J. T., Brivanlou, A. H., Schier, A. F., EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1 (2003) Genes Dev., 17, pp. 31-36
Gray, P. C., Harrison, C. A., Vale, W., Cripto forms a complex with activin and type II activin receptors and can block activin signaling (2003) Proc. Natl. Acad. Sci. U. S. A., 100, pp. 5193-5198
Foley, S. F., Van Vlijmen, H. W., Boynton, R. E., Adkins, H. B., Cheung, A. E., The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis (2003) Eur. J. Biochem., 270, pp. 3610-3618
Risbridger, G. P., Schmitt, J. F., Robertson, D. M., Activins and inhibins in endocrine and other tumors (2001) Endocr. Rev., 22, pp. 836-858
Shen, M. M., Decrypting the role of Cripto in tumorigenesis (2003) J. Clin. Invest., 112, pp. 500-502
Shen, M. M., Schier, A. F., The EGF-CFC gene family in vertebrate development (2000) Trends Genet., 16, pp. 303-309
Persico, M. G., Liguori, G. L., Parisi, S., D'Andrea, D., Salomon, D. S., Cripto in tumors and embryo development (2001) Biochim. Biophys. Acta, 1552, pp. 87-93
Wishart, D. S., Sykes, B. D., Richards, F. M., Relationship between nuclear magnetic resonance chemical shift and protein secondary structure (1991) J. Mol. Biol., 222, pp. 311-333
Harrison, P. M., Sternberg, M. J. E., The disulphide beta-cross: From cystine geometry and clustering to classification of small disulphide-rich protein folds (1996) J. Mol. Biol., 264, pp. 603-623
Schiffer, S. G., Foley, S., Kaffashan, A., Hronowski, X., Zichittella, A. E., Fucosylation of Cripto is required for its ability to facilitate nodal signaling (2001) J. Biol. Chem., 276, pp. 37769-37778
Bax, A., Davis, D. G., MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy (1985) J. Magn. Res., 65, pp. 355-360
States, D. J., Haberhorn, R. A., Ruben, D. J., A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants (1982) J. Magn. Res., 48, pp. 286-292
Johnson, B. A., Blevins, R. A., NMRView: A computer program for the visualization and analysis of NMR data (1994) J. Biomol. NMR, 4, pp. 603-614
Case, D. A., Pearlman, D. A., Caldwell, J. W., Cheatham, I. T. E., Ross, W. S., (1999) AMBER 6, , University of California: San Francisco, CA
Pearlman, D. A., Case, D. A., Caldwell, J. W., Ross, W. S., Cheatham, I. T. E., AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to stimulate the structural and energetic properties of molecules (1996) Proteins, 26, pp. 304-313
Weiner, S. J., Kollmann, P. A., Nguyen, D. T., Case, D. A., An all atom force field for simulations of proteins and nucleic acids (1986) J. Comput. Chem., 7, pp. 230-238
Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala
We report here for the first time the solution structures at pH 3 and pH 6 of the synthetic CFC domain of mouse Cripto and of the point mutated variant W107A that is unable to bind to the Alk4 Cripto receptor. NMR data confirm that the CFC domain has a C1-C4, C2-C6, C3-C5 disulfide pattern and show that structures are rather flexible and globally extended, with three noncanonical antiparallel strands. His104 and Trp107 side chains protrude from a protein edge and are strongly exposed to solvent, supporting previous evidence of direct involvement in receptor binding. On the opposite molecule side, several nonpolar residues are gathered, forming a large hydrophobic patch that supposedly acts as interface with the cell membrane or the adjacent EGF-like domain. A second hydrophilic patch surrounding His104 and Trp107 is present only in the wild type variant, suggesting a possible involvement in modulating Alk4 recognition.
We report here for the first time the solution structures at pH 3 and pH 6 of the synthetic CFC domain of mouse Cripto and of the point mutated variant W107A that is unable to bind to the Alk4 Cripto receptor. NMR data confirm that the CFC domain has a C1-C4, C2-C6, C3-C5 disulfide pattern and show that structures are rather flexible and globally extended, with three noncanonical antiparallel strands. His104 and Trp107 side chains protrude from a protein edge and are strongly exposed to solvent, supporting previous evidence of direct involvement in receptor binding. On the opposite molecule side, several nonpolar residues are gathered, forming a large hydrophobic patch that supposedly acts as interface with the cell membrane or the adjacent EGF-like domain. A second hydrophilic patch surrounding His104 and Trp107 is present only in the wild type variant, suggesting a possible involvement in modulating Alk4 recognition.
Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala
| ▼ Carbonic Anhydrase IX as target for the development of new anti-tumour drugs |
Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala
Other filter: ([btitle,keywords] "2 Dipropylamino 8 Hy ...
Grund ME, Soo JC, Cote CK, Berisio R, Lukomski S
* Thinking Outside the Bug: Targeting Outer Membrane Proteins for Burkholderia Vaccines (22 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2021 Feb 25; 10(3): N/D-N/D.
Impact Factor: 6.6
View Export to BibTeX Export to EndNote
Kramarska E, Squeglia F, De Maio F, Delogu G, Berisio R
* PE_PGRS33, an Important Virulence Factor of Mycobacterium tuberculosis and Potential Target of Host Humoral Immune Response (19 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2021 Jan 15; 10(1): N/D-N/D.
Impact Factor: 6.6
View Export to BibTeX Export to EndNote
Grund ME, Choi SJ, Mcnitt DH, Barbier M, Hu G, Lasala PR, Cote CK, Berisio R, Lukomski S
* Burkholderia collagen-like protein 8, Bucl8, is a unique outer membrane component of a putative tetrapartite efflux pump in Burkholderia pseudomallei and Burkholderia mallei (68 views)
Plosone (ISSN: 1932-6203linking, 1932-6203electronic), 2020 Nov 23; 15(11): e0242593-N/D.
Impact Factor: 2.74
View Export to BibTeX Export to EndNote
Omari KE, Mohamad N, Bountra K, Duman R, Romano M, Schlegel K, Kwong H, Mykhaylyk V, Olesen C, Moller JV, Bublitz M, Beis K, Wagner A
* Experimental phasing with vanadium and application to nucleotide-binding membrane proteins (85 views)
Iucrj (ISSN: 2052-2525linking), 2020 Oct 14; 7(Pt6): 1092-1101.
Impact Factor: 5.4
View Export to BibTeX Export to EndNote
Wong J, Romano M, Kerry LE, Kwong H, Low W, Brett S, J , Clements A, Beis K, Frankel G
* OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo (132 views)
Nature Communications, 2019 Sep; N/D: N/D-N/D.
Impact Factor: 12.121
View Export to BibTeX Export to EndNote
Calvanese L, D'Auria G, Vangone A, Falcigno L, Oliva R
* Structural Basis for Mutations of Human Aquaporins Associated to Genetic Diseases (226 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2018 May 25; 19(6): N/D-N/D.
Impact Factor: 3.687
View Export to BibTeX Export to EndNote
Pirone L, Smaldone G, Esposito C, Balasco N, Petoukhov MV, Spilotros A, Svergun DI, Di Gaetano S, Vitagliano L, Pedone E
* Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners (323 views) (PDF 192 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2016 Sep 24; 131: 106-114.
Impact Factor: 3.112
View Export to BibTeX Export to EndNote
Magri A, Di Rosa MC, Tomasello MF, Guarino F, Reina S, Messina A, De Pinto V
* Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes (366 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Mar 4; 1857(6): 789-798.
Impact Factor: 4.932
View Export to BibTeX Export to EndNote
De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (653 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
View Export to BibTeX Export to EndNote
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (297 views)
N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (571 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
View Export to BibTeX Export to EndNote
De Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazza D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L
* Cullin3 - BTB interface: A novel target for stapled peptides (568 views) (PDF 44 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Apr 7; 10(4): e0121149-e0121149.
Impact Factor: 3.057
View Export to BibTeX Export to EndNote
Calvanese L, Falcigno L, D'Auria G
* Essential Dynamics Analysis Captures the Concerted Motion of the Integrin-Binding Site in Jerdostatin, an RTS Disintegrin (403 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2015 Mar; 103(3): 158-166.
Impact Factor: 2.248
View Export to BibTeX Export to EndNote
Calvanese L, Sandomenico A, Caporale A, Foca A, Foca G, D'Auria G, Falcigno L, Ruvo M
* Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments (496 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015 Jan 15; 21(4): 283-293.
Impact Factor: 1.951
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (513 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2014 Sep 15; 20(18): 4806-4815.
Impact Factor: 8.722
View Export to BibTeX Export to EndNote
Andreotti G, Citro V, Correra A, Cubellis MV
* A thermodynamic assay to test pharmacological chaperones for Fabry disease (394 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1840(3): 1214-1224.
Impact Factor: 4.882
View Export to BibTeX Export to EndNote
De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F
* Renal cells from spermatogonial germline stem cells protect against kidney injury (354 views)
J Am Soc Nephrol (ISSN: 1046-6673), 2014 Feb; 25(2): 316-328.
Impact Factor: 9.343
View Export to BibTeX Export to EndNote
Calce E, Sandomenico A, Saviano M, Ruvo M, De Luca S
* Cysteine Co-Oxidation Process Driven By Native Peptide Folding: An Example On Her2 Receptor Model System (366 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2014; 46(5): 1197-1206.
Impact Factor: 3.293
View Export to BibTeX Export to EndNote
Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (458 views)
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
Impact Factor: 0.635
View Export to BibTeX Export to EndNote
Petruk AA, Varriale S, Coscia MR, Mazzarella L, Merlino A, Oreste U
* The Structure Of The Cd3 Zeta Zeta Transmembrane Dimer In Popc And Raft-Like Lipid Bilayer: A Molecular Dynamics Study (442 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002e, 0005-2736print), 2013 Nov; 1828(11): 2637-2645.
Impact Factor: 3.498
View Export to BibTeX Export to EndNote
Russo Krauss I, Merlino A, Vergara A, Sica F
* An overview of biological macromolecule crystallization (1047 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 May 31; 14(6): 11643-11691.
Impact Factor: 2.339
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (438 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
View Export to BibTeX Export to EndNote
Esposito L, Balasco N, De Simone A, Berisio R, Vitagliano L
* Interplay between peptide bond geometrical parameters in nonglobular structural contexts (463 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: N/D-N/D.
Impact Factor: 2.13
View Export to BibTeX Export to EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (508 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (629 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (675 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
View Export to BibTeX Export to EndNote
Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (488 views)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
View Export to BibTeX Export to EndNote
Riccio A, Cubellis MV
* Gain of function in CDKN1C (503 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
View Export to BibTeX Export to EndNote
Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (382 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Santoro AM, Nicoletti VG, Rizzarelli E
* Copper(II) interaction with peptide fragments of histidine-proline-rich glycoprotein: Speciation, stability and binding details (404 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 59-69.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
* Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (448 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 7; 7(5): e35774-e35774.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Galdiero S, Russo L, Falanga A, Cantisani M, Vitiello M, Fattorusso R, Malgieri G, Galdiero M, Isernia C
* Structure and Orientation of the gH625-644 Membrane Interacting Region of Herpes Simplex Virus Type 1 in a Membrane Mimetic System (368 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Apr 10; 51(14): 3121-3128.
Impact Factor: 3.377
View Export to BibTeX Export to EndNote
Esposito C, Cantisani M, D'Auria G, Falcigno L, Pedone E, Galdiero S, Berisio R
* Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination (461 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2012 Mar 23; 586(6): 659-667.
Impact Factor: 3.582
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (614 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (525 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (853 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
View Export to BibTeX Export to EndNote
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (517 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
View Export to BibTeX Export to EndNote
Troise F, Monti M, Merlino A, Cozzolino F, Fedele C, Russo Krauss I, Sica F, Pucci P, D'Alessio G, De Lorenzo C
* A novel ErbB2 epitope targeted by human antitumor immunoagents (391 views)
Febs Journal (ISSN: 1742-464x), 2011 Apr; 278(7): 1156-1166.
Impact Factor: 3.79
View Export to BibTeX Export to EndNote
Santoro L, Breedveld GJ, Manganelli F, Iodice R, Pisciotta C, Nolano M, Punzo F, Quarantelli M, Pappata S, Di Fonzo A, Oostra BA, Bonifati V
* Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability (368 views)
Neurogenetics (ISSN: 1364-6745, 1364-6753, 1364-6753electronic), 2011 Feb; 12(1): 33-39.
Impact Factor: 3.354
View Export to BibTeX Export to EndNote
Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (2177 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
Impact Factor: 2.282
View Export to BibTeX Export to EndNote
Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A
* Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers (486 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Jan; 1808(1): 34-40.
Impact Factor: 3.99
View Export to BibTeX Export to EndNote
Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (592 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
View Export to BibTeX Export to EndNote
Limauro D, D'Ambrosio K, Langella E, De Simone G, Galdi I, Pedone C, Pedone E, Bartolucci S
* Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus (373 views)
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2010 Oct; 92(10): 1435-1444.
Impact Factor: 3.787
View Export to BibTeX Export to EndNote
Di Fiore A, Truppo E, Supuran CT, Alterio V, Dathan N, Bootorabi F, Parkkila S, Monti SM, De Simone G
* Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide (325 views)
Bioorg Med Chem Lett (ISSN: 0960-894x), 2010 Sep 1; 20(17): 5023-5026.
Impact Factor: 2.661
View Export to BibTeX Export to EndNote
Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (771 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
View Export to BibTeX Export to EndNote
Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M
* NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH (519 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2010 Jul; 76(1): 10-16.
Impact Factor: 2.527
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (617 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
View Export to BibTeX Export to EndNote
Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (395 views)
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
Impact Factor: 2.266
View Export to BibTeX Export to EndNote
Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
* Biochemical Characterisation Of The D60a Mutant Of The Elongation Factor 1 Alpha From The Archaeon Sulfolobus Solfataricus (307 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2009 Jul; 91(7): 835-842.
Impact Factor: 3.897
View Export to BibTeX Export to EndNote
Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
View Export to BibTeX Export to EndNote
Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (457 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
* Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis (571 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009 Jan 9; 385(1): 153-162.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, De Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, De Franciscis V
* Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (448 views)
Oncology (ISSN: 0030-2414), 2009; 77(6): 378-384.
Impact Factor: 2.112
View Export to BibTeX Export to EndNote
Chambery A, Vissers JPC, Langridge JI, Lonardo E, Minchiotti G, Ruvo M, Parente A
* Qualitative and quantitative proteomic profiling of cripto-1- embryonic stem cells by means of accurate mass LC-MS analysis (1015 views)
J Proteome Res (ISSN: 1535-3893), 2009; 8(2): 1047-1058.
Impact Factor: 5.132
View Export to BibTeX Export to EndNote
Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (459 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (377 views)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
View Export to BibTeX Export to EndNote
Mandrich L, Menchise V, Alterio V, De Simone G, Pedone C, Rossi M, Manco G
* Functional and structural features of the oxyanion hole in a thermophilic esterase from Alicyclobacillus acidocaldarius (409 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2008 Jun; 71(4): 1721-1731.
Impact Factor: 3.419
View Export to BibTeX Export to EndNote
Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (874 views)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
View Export to BibTeX Export to EndNote
Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (419 views)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (584 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
Impact Factor: 3.446
View Export to BibTeX Export to EndNote
De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (469 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
Impact Factor: 3.446
View Export to BibTeX Export to EndNote
Vitagliano L, Ruggiero A, Pedone C, Berisio R
* A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (447 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
Impact Factor: 4.472
View Export to BibTeX Export to EndNote
Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (438 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
View Export to BibTeX Export to EndNote
Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (372 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
View Export to BibTeX Export to EndNote
Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (363 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Barone V, De Rienzo F, Langella E, Menziani MC, Rega N, Sola M
* A computational protocol to probe the role of solvation effects on the reduction potential of azurin mutants (272 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jan 1; 62(1): 262-269.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A
* A crevice adjoining the ribosome tunnel: Hints for cotranslational folding (388 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Jun 13; 579(15): 3207-3213.
Impact Factor: 3.415
View Export to BibTeX Export to EndNote
Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (441 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 May 6; 280(18): 17953-17960.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
De Simone G, Menchise V, Alterio V, Mandrich L, Rossi M, Manco G, Pedone C
* The crystal structure of an EST2 mutant unveils structural insights on the H group of the carboxylesterase/lipase family (839 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2004 Oct 8; 343(1): 137-146.
Impact Factor: 5.542
View Export to BibTeX Export to EndNote
Pedone E, Ren B, Ladenstein R, Rossi M, Bartolucci S
* Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus - A member of a novel protein family related to protein disulfide-isomerase (390 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print), 2004 Sep; 271(16): 3437-3448.
Impact Factor: 3.26
View Export to BibTeX Export to EndNote
Galdiero S, Gouaux E
* High Resolution Crystallographic Studies Of Alpha-Hemolysin-Phospholipid Complexes Define Heptamer-Lipid Head Group Interactions: Implication For Understanding Protein-Lipid Interactions (320 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2004 Jun; 13(6): 1503-1511.
Impact Factor: 4.116
View Export to BibTeX Export to EndNote
Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (438 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004 May 25; 43(20): 6043-6058.
Impact Factor: 4.008
View Export to BibTeX Export to EndNote
Esposito G, Vitagliano L, Costanzo P, Borrelli L, Barone R, Pavone L, Izzo P, Zagari A, Salvatore F
* Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function (378 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2004 May 15; 380: 51-56.
Impact Factor: 4.278
View Export to BibTeX Export to EndNote
Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (475 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
View Export to BibTeX Export to EndNote
Milardi D, Grasso DM, Verbeet MP, Canters GW, La Rosa C
* Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: Synergism among multiple depletions (330 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2003 Jun 1; 414(1): 121-127.
Impact Factor: 2.338
View Export to BibTeX Export to EndNote
Galdiero S, Capasso D, Vitiello M, D'Isanto M, Pedone C, Galdiero M
* Protein P2 from Haemophilus influenzae: The role of its surface exposed loops on the mitogen-activated protein kinase cascade (376 views)
Infection And Immunity (ISSN: 0019-9567), 2003 May; 71(5): 2798-2809.
Impact Factor: 3.875
View Export to BibTeX Export to EndNote
Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (437 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
View Export to BibTeX Export to EndNote
Esposito G, Vitagliano L, Santamaria R, Viola A, Zagari A, Salvatore F
* Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance (309 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2002 Nov 6; 531(2): 152-156.
Impact Factor: 3.912
View Export to BibTeX Export to EndNote
Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (654 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
View Export to BibTeX Export to EndNote
Menchise V, Corbier C, Didierjean C, Saviano M, Benedetti E, Jacquot JP, Aubry A
* Crystal structure of the wild-type and D30A mutant thioredoxin h of Chlamydomonas reinhardtii and implications for the catalytic mechanism (424 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2001 Oct 1; 359(1): 65-75.
Impact Factor: 4.326
View Export to BibTeX Export to EndNote
Del Vecchio S, Ciarmiello A, Salvatore M
Clinical imaging of multidrug resistance in cancer (361 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1999 Jun; 43(2): 125-131.
Impact Factor: 2.125
View Export to BibTeX Export to EndNote
Mazzarella L, D'Avino R, Di Prisco G, Savino C, Vitagliano L, Moody P, Zagari A
Crystal structure of Trematomus newnesi haemoglobin re-opens the Root effect question (388 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Apr 16; 287(5): 897-906.
Impact Factor: 5.501
View Export to BibTeX Export to EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
View Export to BibTeX Export to EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
Cytosine arabinoside increases the binding of 125I-labelled epidermal growth factor and 125I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor) mAb (236 views)
Cancer Immunol Immunother (ISSN: 0340-7004linking), 1993 Aug; 37 (3 ): 150-156.
Impact Factor: 4.293
View Export to BibTeX Export to EndNote
Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
* Thinking Outside the Bug: Targeting Outer Membrane Proteins for Burkholderia Vaccines (22 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2021 Feb 25; 10(3): N/D-N/D.
Impact Factor: 6.6
View Export to BibTeX Export to EndNote
Kramarska E, Squeglia F, De Maio F, Delogu G, Berisio R
* PE_PGRS33, an Important Virulence Factor of Mycobacterium tuberculosis and Potential Target of Host Humoral Immune Response (19 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2021 Jan 15; 10(1): N/D-N/D.
Impact Factor: 6.6
View Export to BibTeX Export to EndNote
Grund ME, Choi SJ, Mcnitt DH, Barbier M, Hu G, Lasala PR, Cote CK, Berisio R, Lukomski S
* Burkholderia collagen-like protein 8, Bucl8, is a unique outer membrane component of a putative tetrapartite efflux pump in Burkholderia pseudomallei and Burkholderia mallei (68 views)
Plosone (ISSN: 1932-6203linking, 1932-6203electronic), 2020 Nov 23; 15(11): e0242593-N/D.
Impact Factor: 2.74
View Export to BibTeX Export to EndNote
Omari KE, Mohamad N, Bountra K, Duman R, Romano M, Schlegel K, Kwong H, Mykhaylyk V, Olesen C, Moller JV, Bublitz M, Beis K, Wagner A
* Experimental phasing with vanadium and application to nucleotide-binding membrane proteins (85 views)
Iucrj (ISSN: 2052-2525linking), 2020 Oct 14; 7(Pt6): 1092-1101.
Impact Factor: 5.4
View Export to BibTeX Export to EndNote
Wong J, Romano M, Kerry LE, Kwong H, Low W, Brett S, J , Clements A, Beis K, Frankel G
* OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo (132 views)
Nature Communications, 2019 Sep; N/D: N/D-N/D.
Impact Factor: 12.121
View Export to BibTeX Export to EndNote
Calvanese L, D'Auria G, Vangone A, Falcigno L, Oliva R
* Structural Basis for Mutations of Human Aquaporins Associated to Genetic Diseases (226 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2018 May 25; 19(6): N/D-N/D.
Impact Factor: 3.687
View Export to BibTeX Export to EndNote
Pirone L, Smaldone G, Esposito C, Balasco N, Petoukhov MV, Spilotros A, Svergun DI, Di Gaetano S, Vitagliano L, Pedone E
* Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners (323 views) (PDF 192 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2016 Sep 24; 131: 106-114.
Impact Factor: 3.112
View Export to BibTeX Export to EndNote
Magri A, Di Rosa MC, Tomasello MF, Guarino F, Reina S, Messina A, De Pinto V
* Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes (366 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Mar 4; 1857(6): 789-798.
Impact Factor: 4.932
View Export to BibTeX Export to EndNote
De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (653 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
View Export to BibTeX Export to EndNote
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (297 views)
N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (571 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
View Export to BibTeX Export to EndNote
De Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazza D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L
* Cullin3 - BTB interface: A novel target for stapled peptides (568 views) (PDF 44 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Apr 7; 10(4): e0121149-e0121149.
Impact Factor: 3.057
View Export to BibTeX Export to EndNote
Calvanese L, Falcigno L, D'Auria G
* Essential Dynamics Analysis Captures the Concerted Motion of the Integrin-Binding Site in Jerdostatin, an RTS Disintegrin (403 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2015 Mar; 103(3): 158-166.
Impact Factor: 2.248
View Export to BibTeX Export to EndNote
Calvanese L, Sandomenico A, Caporale A, Foca A, Foca G, D'Auria G, Falcigno L, Ruvo M
* Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments (496 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015 Jan 15; 21(4): 283-293.
Impact Factor: 1.951
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (513 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2014 Sep 15; 20(18): 4806-4815.
Impact Factor: 8.722
View Export to BibTeX Export to EndNote
Andreotti G, Citro V, Correra A, Cubellis MV
* A thermodynamic assay to test pharmacological chaperones for Fabry disease (394 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1840(3): 1214-1224.
Impact Factor: 4.882
View Export to BibTeX Export to EndNote
De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F
* Renal cells from spermatogonial germline stem cells protect against kidney injury (354 views)
J Am Soc Nephrol (ISSN: 1046-6673), 2014 Feb; 25(2): 316-328.
Impact Factor: 9.343
View Export to BibTeX Export to EndNote
Calce E, Sandomenico A, Saviano M, Ruvo M, De Luca S
* Cysteine Co-Oxidation Process Driven By Native Peptide Folding: An Example On Her2 Receptor Model System (366 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2014; 46(5): 1197-1206.
Impact Factor: 3.293
View Export to BibTeX Export to EndNote
Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (458 views)
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
Impact Factor: 0.635
View Export to BibTeX Export to EndNote
Petruk AA, Varriale S, Coscia MR, Mazzarella L, Merlino A, Oreste U
* The Structure Of The Cd3 Zeta Zeta Transmembrane Dimer In Popc And Raft-Like Lipid Bilayer: A Molecular Dynamics Study (442 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002e, 0005-2736print), 2013 Nov; 1828(11): 2637-2645.
Impact Factor: 3.498
View Export to BibTeX Export to EndNote
Russo Krauss I, Merlino A, Vergara A, Sica F
* An overview of biological macromolecule crystallization (1047 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 May 31; 14(6): 11643-11691.
Impact Factor: 2.339
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (438 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
View Export to BibTeX Export to EndNote
Esposito L, Balasco N, De Simone A, Berisio R, Vitagliano L
* Interplay between peptide bond geometrical parameters in nonglobular structural contexts (463 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: N/D-N/D.
Impact Factor: 2.13
View Export to BibTeX Export to EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (508 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (629 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (675 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
View Export to BibTeX Export to EndNote
Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (488 views)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
View Export to BibTeX Export to EndNote
Riccio A, Cubellis MV
* Gain of function in CDKN1C (503 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
View Export to BibTeX Export to EndNote
Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (382 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Santoro AM, Nicoletti VG, Rizzarelli E
* Copper(II) interaction with peptide fragments of histidine-proline-rich glycoprotein: Speciation, stability and binding details (404 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 59-69.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
* Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (448 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 7; 7(5): e35774-e35774.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Galdiero S, Russo L, Falanga A, Cantisani M, Vitiello M, Fattorusso R, Malgieri G, Galdiero M, Isernia C
* Structure and Orientation of the gH625-644 Membrane Interacting Region of Herpes Simplex Virus Type 1 in a Membrane Mimetic System (368 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Apr 10; 51(14): 3121-3128.
Impact Factor: 3.377
View Export to BibTeX Export to EndNote
Esposito C, Cantisani M, D'Auria G, Falcigno L, Pedone E, Galdiero S, Berisio R
* Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination (461 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2012 Mar 23; 586(6): 659-667.
Impact Factor: 3.582
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (614 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (525 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (853 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
View Export to BibTeX Export to EndNote
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (517 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
View Export to BibTeX Export to EndNote
Troise F, Monti M, Merlino A, Cozzolino F, Fedele C, Russo Krauss I, Sica F, Pucci P, D'Alessio G, De Lorenzo C
* A novel ErbB2 epitope targeted by human antitumor immunoagents (391 views)
Febs Journal (ISSN: 1742-464x), 2011 Apr; 278(7): 1156-1166.
Impact Factor: 3.79
View Export to BibTeX Export to EndNote
Santoro L, Breedveld GJ, Manganelli F, Iodice R, Pisciotta C, Nolano M, Punzo F, Quarantelli M, Pappata S, Di Fonzo A, Oostra BA, Bonifati V
* Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability (368 views)
Neurogenetics (ISSN: 1364-6745, 1364-6753, 1364-6753electronic), 2011 Feb; 12(1): 33-39.
Impact Factor: 3.354
View Export to BibTeX Export to EndNote
Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (2177 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
Impact Factor: 2.282
View Export to BibTeX Export to EndNote
Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A
* Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers (486 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Jan; 1808(1): 34-40.
Impact Factor: 3.99
View Export to BibTeX Export to EndNote
Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (592 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
View Export to BibTeX Export to EndNote
Limauro D, D'Ambrosio K, Langella E, De Simone G, Galdi I, Pedone C, Pedone E, Bartolucci S
* Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus (373 views)
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2010 Oct; 92(10): 1435-1444.
Impact Factor: 3.787
View Export to BibTeX Export to EndNote
Di Fiore A, Truppo E, Supuran CT, Alterio V, Dathan N, Bootorabi F, Parkkila S, Monti SM, De Simone G
* Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide (325 views)
Bioorg Med Chem Lett (ISSN: 0960-894x), 2010 Sep 1; 20(17): 5023-5026.
Impact Factor: 2.661
View Export to BibTeX Export to EndNote
Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (771 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
View Export to BibTeX Export to EndNote
Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M
* NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH (519 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2010 Jul; 76(1): 10-16.
Impact Factor: 2.527
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (617 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
View Export to BibTeX Export to EndNote
Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (395 views)
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
Impact Factor: 2.266
View Export to BibTeX Export to EndNote
Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
* Biochemical Characterisation Of The D60a Mutant Of The Elongation Factor 1 Alpha From The Archaeon Sulfolobus Solfataricus (307 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2009 Jul; 91(7): 835-842.
Impact Factor: 3.897
View Export to BibTeX Export to EndNote
Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
View Export to BibTeX Export to EndNote
Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (457 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
* Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis (571 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009 Jan 9; 385(1): 153-162.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, De Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, De Franciscis V
* Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (448 views)
Oncology (ISSN: 0030-2414), 2009; 77(6): 378-384.
Impact Factor: 2.112
View Export to BibTeX Export to EndNote
Chambery A, Vissers JPC, Langridge JI, Lonardo E, Minchiotti G, Ruvo M, Parente A
* Qualitative and quantitative proteomic profiling of cripto-1- embryonic stem cells by means of accurate mass LC-MS analysis (1015 views)
J Proteome Res (ISSN: 1535-3893), 2009; 8(2): 1047-1058.
Impact Factor: 5.132
View Export to BibTeX Export to EndNote
Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (459 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (377 views)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
View Export to BibTeX Export to EndNote
Mandrich L, Menchise V, Alterio V, De Simone G, Pedone C, Rossi M, Manco G
* Functional and structural features of the oxyanion hole in a thermophilic esterase from Alicyclobacillus acidocaldarius (409 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2008 Jun; 71(4): 1721-1731.
Impact Factor: 3.419
View Export to BibTeX Export to EndNote
Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (874 views)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
View Export to BibTeX Export to EndNote
Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (419 views)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (584 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
Impact Factor: 3.446
View Export to BibTeX Export to EndNote
De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (469 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
Impact Factor: 3.446
View Export to BibTeX Export to EndNote
Vitagliano L, Ruggiero A, Pedone C, Berisio R
* A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (447 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
Impact Factor: 4.472
View Export to BibTeX Export to EndNote
Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (438 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
View Export to BibTeX Export to EndNote
Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (372 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
View Export to BibTeX Export to EndNote
Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (363 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Barone V, De Rienzo F, Langella E, Menziani MC, Rega N, Sola M
* A computational protocol to probe the role of solvation effects on the reduction potential of azurin mutants (272 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jan 1; 62(1): 262-269.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A
* A crevice adjoining the ribosome tunnel: Hints for cotranslational folding (388 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Jun 13; 579(15): 3207-3213.
Impact Factor: 3.415
View Export to BibTeX Export to EndNote
Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (441 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 May 6; 280(18): 17953-17960.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
De Simone G, Menchise V, Alterio V, Mandrich L, Rossi M, Manco G, Pedone C
* The crystal structure of an EST2 mutant unveils structural insights on the H group of the carboxylesterase/lipase family (839 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2004 Oct 8; 343(1): 137-146.
Impact Factor: 5.542
View Export to BibTeX Export to EndNote
Pedone E, Ren B, Ladenstein R, Rossi M, Bartolucci S
* Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus - A member of a novel protein family related to protein disulfide-isomerase (390 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print), 2004 Sep; 271(16): 3437-3448.
Impact Factor: 3.26
View Export to BibTeX Export to EndNote
Galdiero S, Gouaux E
* High Resolution Crystallographic Studies Of Alpha-Hemolysin-Phospholipid Complexes Define Heptamer-Lipid Head Group Interactions: Implication For Understanding Protein-Lipid Interactions (320 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2004 Jun; 13(6): 1503-1511.
Impact Factor: 4.116
View Export to BibTeX Export to EndNote
Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (438 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004 May 25; 43(20): 6043-6058.
Impact Factor: 4.008
View Export to BibTeX Export to EndNote
Esposito G, Vitagliano L, Costanzo P, Borrelli L, Barone R, Pavone L, Izzo P, Zagari A, Salvatore F
* Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function (378 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2004 May 15; 380: 51-56.
Impact Factor: 4.278
View Export to BibTeX Export to EndNote
Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (475 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
View Export to BibTeX Export to EndNote
Milardi D, Grasso DM, Verbeet MP, Canters GW, La Rosa C
* Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: Synergism among multiple depletions (330 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2003 Jun 1; 414(1): 121-127.
Impact Factor: 2.338
View Export to BibTeX Export to EndNote
Galdiero S, Capasso D, Vitiello M, D'Isanto M, Pedone C, Galdiero M
* Protein P2 from Haemophilus influenzae: The role of its surface exposed loops on the mitogen-activated protein kinase cascade (376 views)
Infection And Immunity (ISSN: 0019-9567), 2003 May; 71(5): 2798-2809.
Impact Factor: 3.875
View Export to BibTeX Export to EndNote
Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (437 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
View Export to BibTeX Export to EndNote
Esposito G, Vitagliano L, Santamaria R, Viola A, Zagari A, Salvatore F
* Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance (309 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2002 Nov 6; 531(2): 152-156.
Impact Factor: 3.912
View Export to BibTeX Export to EndNote
Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (654 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
View Export to BibTeX Export to EndNote
Menchise V, Corbier C, Didierjean C, Saviano M, Benedetti E, Jacquot JP, Aubry A
* Crystal structure of the wild-type and D30A mutant thioredoxin h of Chlamydomonas reinhardtii and implications for the catalytic mechanism (424 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2001 Oct 1; 359(1): 65-75.
Impact Factor: 4.326
View Export to BibTeX Export to EndNote
Del Vecchio S, Ciarmiello A, Salvatore M
Clinical imaging of multidrug resistance in cancer (361 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1999 Jun; 43(2): 125-131.
Impact Factor: 2.125
View Export to BibTeX Export to EndNote
Mazzarella L, D'Avino R, Di Prisco G, Savino C, Vitagliano L, Moody P, Zagari A
Crystal structure of Trematomus newnesi haemoglobin re-opens the Root effect question (388 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Apr 16; 287(5): 897-906.
Impact Factor: 5.501
View Export to BibTeX Export to EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
View Export to BibTeX Export to EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
Cytosine arabinoside increases the binding of 125I-labelled epidermal growth factor and 125I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor) mAb (236 views)
Cancer Immunol Immunother (ISSN: 0340-7004linking), 1993 Aug; 37 (3 ): 150-156.
Impact Factor: 4.293
View Export to BibTeX Export to EndNote
Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
88 Records (82 excluding Abstracts).
Total impact factor: 457.363 (434.043 excluding Abstracts).
Total 5 year impact factor: 468.63 (443.939 excluding Abstracts).
Total impact factor: 457.363 (434.043 excluding Abstracts).
Total 5 year impact factor: 468.63 (443.939 excluding Abstracts).
459 views. Last view on Monday 27 March 2023, 10:09:36
ibb.cnr.it
