Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound(434 views) Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
Keywords: Adduct Formation, Bovine Pancreatic Ribonuclease, Cytotoxic, Dinuclear, Esi Mass Spectrometry, Mode Of Action, Model Proteins, X Ray Diffraction, Gold, Auoxo6, Auranofin, Gold Complex, Histidine, Ligand, Metallodrug, Peroxiredoxin, Prodrug, Thioredoxin Reductase, Unclassified Drug, Antineoplastic Activity, Cattle, Chemical Structure, Complex Formation, Conference Paper, Crystal Structure, Electrospray Mass Spectrometry, Enzyme Activity, Nonhuman, Priority Journal, Animals, Cell Death, Crystallography, X-Ray, Hydrolysis, Molecular, Saccharomyces Cerevisiae, Electrospray Ionization,
Affiliations: *** IBB - CNR ***
Department of Chemistry Ugo Schiff, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy
CNR Institute of Biostructures and Bioimages, Napoli, Italy
References: Not available.
Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound
The reaction of Auoxo6, a dinuclear gold(III) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.
Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound
No results.
Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound