The mode of action of anticancer gold-based drugs: a structural perspective(455 views) Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A
Keywords: Antineoplastic Agent, Cisplatin, Glutathione Reductase, Gold Derivative, Antineoplastic Activity, Article, Controlled Study, Crystal Structure, Drug Structure, Electrospray Mass Spectrometry, Enzyme Inhibition, X Ray Crystallography, Auranofin, Binding Sites, X-Ray, Drug Design, Models, Molecular, Molecular Structure, Muramidase, Organometallic Compounds, Protein Binding,
Affiliations: *** IBB - CNR ***
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy
References: Not available.
The mode of action of anticancer gold-based drugs: a structural perspective
The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.
The mode of action of anticancer gold-based drugs: a structural perspective
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The mode of action of anticancer gold-based drugs: a structural perspective
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