Polymerization of Hemoglobins in Arctic Fish: Lycodes reticulatus and Gadus morhua(361 views) Riccio A, Mangiapia G, Giordano D, Flagiello A, Tedesco R, Bruno S, Vergara A, Mazzarella L, di Prisco G, Pucci P, Paduano L, Verde C
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 May; 63(5): 346-354.
Keywords: Arctic, Fish, Hemoglobin, Polymerization, Cysteine, Disulfide, Alpha Chain, Amino Acid Sequence, Animal Experiment, Article, Atlantic Cod, Beta Chain, Light Scattering, Lycodes Reticulatus, Matrix Assisted Laser Desorption Ionization Time Of Flight Mass Spectrometry, Nonhuman, Oxygen Affinity, Protein Polymerization, Arctic Regions, Gadus Morhua, Molecular Sequence Data, Protein Conformation, Sequence Alignment, Matrix-Assisted Laser Desorption-Ionization, Zoarcidae, Chemistry, Genetics, Metabolism,
Affiliations: *** IBB - CNR ***
Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I-80131 Naples, Italy
Department of Chemistry, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cinthia, Naples, Italy
CEINGE Biotecnologie Avanzate, Università di Napoli Federico II, Via G. Salvatore 486, Napoli, Italy
Dipartimento di Biochimica e Biologia Molecolare, Università di Parma, Viale G.P. Usberti 23/A, Parma, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, Naples, Italy
Department of Organic Chemistry and Biochemistry, University of Naples Federico II, Naples, Italy
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Yoffey, J. M., A contribution to the study of the comparative histology and physiology of the spleen, with reference chiefly to its cellular constituents. I. in Fishes (1929) J. Anat., 63, pp. 314-344
Harosi, F. I., Von Herbing, I. H., Van Keuren, J. R., Sickling of anoxic red blood cells in fish (1998) Biological Bulletin, 195 (1), pp. 5-11
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Mathews, H. J., Rohlfs, R. J., Olson, J. S., Tame, J., Renaud, J. P., Nagai, K., The effects of E7 and E11 mutations on the kinetics of ligand binding to R state human haemoglobin (1989) J. Biol. Chem., 264, pp. 16573-16583
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Polymerization of Hemoglobins in Arctic Fish: Lycodes reticulatus and Gadus morhua
In vitro, and possibly in vivo, hemoglobin polymerization and red blood cell sickling appear to be widespread in codfish. In this article, we show that the hemoglobins of the two Arctic fish Lycodes reticulatus and Gadus morhua also have the tendency to polymerize, as monitored by dynamic light scattering experiments. The elucidation of the primary structure of the single hemoglobin of the zoarcid L. reticulatus shows the presence of a large number of cysteyl residues in alpha and beta chains. Their role in eliciting the ability to produce polymers was also addressed by MALDI-TOF and TOF-TOF mass spectrometry. The G. morhua globins are also rich in Cys, but unlike in L. reticulatus, polymerization does not seem to be disulfide driven. The widespread occurrence of the polymerization phenomenon displayed by hemoglobins of Arctic fish supports the hypothesis that this feature may be a response to stressful environmental conditions. (C) 2011 IUBMB IUBMB Life, 63(5): 346-354, 2011
Polymerization of Hemoglobins in Arctic Fish: Lycodes reticulatus and Gadus morhua
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