Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
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Paper type: Journal Article,
Impact factor: 1.826, 5-year impact factor: 2.165
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034546724&partnerID=40&md5=c5226c114a313202edafd8f40bdb0afe
Keywords: Dna Binding Protein, Dna Hybrid, Double Stranded Dna, Hybrid Protein, Immunoglobulin Enhancer Binding Protein, Oligonucleotide, Peptide Nucleic Acid, Phosphate, Article, Binding Site, Computer Simulation, Dna Dna Hybridization, Dna Protein Complex, Drug Activity, Gel Mobility Shift Assay, Molecular Interaction, Molecular Mimicry, Molecular Model, Molecular Recognition, Priority Journal, Protein Cross Linking, Base Sequence, Viral, Hiv-1, Humans, Nf-Kappa B, Nucleic Acid Conformation, Protein Binding, Thermodynamics,
Affiliations:
Biocrystallography Research Centre, CNR, Centro Interuniversitario di Ricerca, Via Mezzocannone n.4, 80134 Napoli, Italy
References:
Berg, O.G., Von Hippel, P.H., (1988) Trends Biochem. Sci., 13, pp. 207-21
Mitchell, P.J., Tjian, R., (1989) Science, 2, pp. 371-378
Gaynor, G., (1992) AIDS, 6, pp. 347-363
Weis, L., Reinberg, D., (1992) FASEB J., 6, pp. 3300-3309
Wingender, E., (1988) Nucleic Acids Res., 16, pp. 357-369
Faisst, S., Meyer, S., (1992) Nucleic Acids Res., 20, pp. 3-26
Locker, J., (1993), pp. 321-345. , Gene Transcription: A practical Approach, (Hamens BD and Higgins SJ eds.), Oxford University Press, Oxford, UKMorishita, R., Sugimoto, T., Aoki, M., Kida, I., Tomita, N., Moriguchi, A., Maeda, K., Ogihara, T., (1997) Nat. Med., 3, pp. 894-899
Lim, C.S., Jabrane-Ferrat, N., Fontes, J.D., Okamoto, H., Garovoy, M.R., Peterlin, B.M., Hunt, C.A., (1997) Nucleic Acids Res., 25, pp. 575-581
Piva, R., Gambari, R., (1999) Minerva Biotecnologica, 11, pp. 193-203
Fraisier, C., Irvine, A., Wrighton, C., Craig, R., Dzierzak, E., (1998) Gene Ther., 5, pp. 1665-1676
Uhlmann, E., Peyman, A., (1990) Chem. Rev., 90, pp. 543-584
Nielsen, P.E., Egholm, M., Berg, R.H., Buchardt, O., (1991) Science, 254, pp. 1497-1500
Egholm, M., Buchardt, O., Christiensen, L., Behrens, C., Freier, S.M., Driver, D.A., Berg, R.H., Nielsen, P.E., (1993) Nature, 365, pp. 566-568
Betts, L., Josey, J.A., Veal, J.M., Jordan, S.R., (1995) Science, 270, pp. 1838-1841
Hanvey, J.C., Peffer, N.J., Bisi, J.E., Thomson, S.A., Cadilla, R., Josey, J.A., Ricca, D.J., Babiss, L.E., (1992) Science, 258, pp. 1481-1485
Demidov, V.V., Yavnilovich, M.V., Belotserkovskii, B.P., Frank-Kamenetskii, M.D., Nielsen, P.E., (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 2637-2641
Larsen, H.J., Nielsen, P.E., (1996) Nucleic Acids Res., 24, pp. 458-463
Demidov, V.V., Potaman, V.N., Frank-Kamenetskii, M.D., Egholm, M., Buchard, O., Sonnichsen, S.H., Nielsen, P.E., (1994) Biochem. Pharmacol., 48, pp. 1310-1313
Mischiati, C., Borgatti, M., Bianchi, N., Rutigliano, C., Tomassetti, M., Feriotto, G., Gambari, R., (1999) JBC, 274, pp. 33114-33122
Cramer, P., Larson, C.J., Verdine, G.L., Müller, C.W., (1997) Embo J., 16, pp. 7078-7090
Chen, F.E., Huang, D., Chen, Y., Ghosh, G., (1998) Nature, 391, pp. 410-413
Ghost, G., Van Duyne, G., Ghosh, S., Sigler, P.B., (1995) Nature, 373, pp. 303-310
Müller, C.W., Rey, F.A., Sodeoka, M., Verdine, G.L., Harrison, S.C., (1995) Nature, 373, pp. 311-317
Barbieri, R., Giacomini, P., Volinia, S., Nastruzzi, C., Mileo, A.M., Ferrini, U., Soria, M., Gambari, R., (1990) FEBS Lett., 268, pp. 51-54
Sagami, I., Tsai, S.Y., Wang, H., Tsai, M.J., O'Malley, B.W., (1986) Mol. Cell. Biol., 6, pp. 4259-4267
Saviano, M., Aida, M., Corongiu, G., (1991) Biopolymers, 31, pp. 1017-1024
Sen, S., Nilsson, L., (1998) J. Am. Chem. Soc., 120, pp. 619-631
Bianchi, N., Passadore, M., Rutigliano, C., Feriotto, G., Mischiati, C., Gambari, R., (1996) Biochem. Pharmacol., 52, pp. 1489-1498
Dignam, J.D., Lebovitz, R.M., Roeder, R.G., (1983) Nucleic Acids Res., 11, pp. 1475-1489
Soliva, R., Sherer, E., Luque, F.J., Laughton, C.A., Orozco, M., (2000) J. Am. Chem. Soc., 122, pp. 5997-6008
Finn, P.J., Gibson, N.J., Fallon, R., Hamilton, A., Brown, T., (1996) Nucleic Acids Res., 24, pp. 3357-3363
Sforza, S., Corradini, R., Galaverna, G., Dossena, A., Marchelli, R., (1999) Minerva Biotecnologica, 11, pp. 163-174
Van der Laan, A.C., Van Amsterdam, I., Tesser, G.I., Van Boom, J.H., Kuyl-Yeheskiely, E., (1998) Nucleosides and Nucleotides, 17, pp. 219-231
Berg, O. G., Von Hippel, P. H., (1988) Trends Biochem. Sci., 13, pp. 207-21
Mitchell, P. J., Tjian, R., (1989) Science, 2, pp. 371-378
Lim, C. S., Jabrane-Ferrat, N., Fontes, J. D., Okamoto, H., Garovoy, M. R., Peterlin, B. M., Hunt, C. A., (1997) Nucleic Acids Res., 25, pp. 575-581
Nielsen, P. E., Egholm, M., Berg, R. H., Buchardt, O., (1991) Science, 254, pp. 1497-1500
Hanvey, J. C., Peffer, N. J., Bisi, J. E., Thomson, S. A., Cadilla, R., Josey, J. A., Ricca, D. J., Babiss, L. E., (1992) Science, 258, pp. 1481-1485
Demidov, V. V., Yavnilovich, M. V., Belotserkovskii, B. P., Frank-Kamenetskii, M. D., Nielsen, P. E., (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 2637-2641
Larsen, H. J., Nielsen, P. E., (1996) Nucleic Acids Res., 24, pp. 458-463
Demidov, V. V., Potaman, V. N., Frank-Kamenetskii, M. D., Egholm, M., Buchard, O., Sonnichsen, S. H., Nielsen, P. E., (1994) Biochem. Pharmacol., 48, pp. 1310-1313
Chen, F. E., Huang, D., Chen, Y., Ghosh, G., (1998) Nature, 391, pp. 410-413
M ller, C. W., Rey, F. A., Sodeoka, M., Verdine, G. L., Harrison, S. C., (1995) Nature, 373, pp. 311-317
Dignam, J. D., Lebovitz, R. M., Roeder, R. G., (1983) Nucleic Acids Res., 11, pp. 1475-1489
Finn, P. J., Gibson, N. J., Fallon, R., Hamilton, A., Brown, T., (1996) Nucleic Acids Res., 24, pp. 3357-3363
Van der Laan, A. C., Van Amsterdam, I., Tesser, G. I., Van Boom, J. H., Kuyl-Yeheskiely, E., (1998) Nucleosides and Nucleotides, 17, pp. 219-231
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.826, 5-year impact factor: 2.165
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034546724&partnerID=40&md5=c5226c114a313202edafd8f40bdb0afe
Keywords: Dna Binding Protein, Dna Hybrid, Double Stranded Dna, Hybrid Protein, Immunoglobulin Enhancer Binding Protein, Oligonucleotide, Peptide Nucleic Acid, Phosphate, Article, Binding Site, Computer Simulation, Dna Dna Hybridization, Dna Protein Complex, Drug Activity, Gel Mobility Shift Assay, Molecular Interaction, Molecular Mimicry, Molecular Model, Molecular Recognition, Priority Journal, Protein Cross Linking, Base Sequence, Viral, Hiv-1, Humans, Nf-Kappa B, Nucleic Acid Conformation, Protein Binding, Thermodynamics,
Affiliations:
Biocrystallography Research Centre, CNR, Centro Interuniversitario di Ricerca, Via Mezzocannone n.4, 80134 Napoli, Italy
References:
Berg, O.G., Von Hippel, P.H., (1988) Trends Biochem. Sci., 13, pp. 207-21
Mitchell, P.J., Tjian, R., (1989) Science, 2, pp. 371-378
Gaynor, G., (1992) AIDS, 6, pp. 347-363
Weis, L., Reinberg, D., (1992) FASEB J., 6, pp. 3300-3309
Wingender, E., (1988) Nucleic Acids Res., 16, pp. 357-369
Faisst, S., Meyer, S., (1992) Nucleic Acids Res., 20, pp. 3-26
Locker, J., (1993), pp. 321-345. , Gene Transcription: A practical Approach, (Hamens BD and Higgins SJ eds.), Oxford University Press, Oxford, UKMorishita, R., Sugimoto, T., Aoki, M., Kida, I., Tomita, N., Moriguchi, A., Maeda, K., Ogihara, T., (1997) Nat. Med., 3, pp. 894-899
Lim, C.S., Jabrane-Ferrat, N., Fontes, J.D., Okamoto, H., Garovoy, M.R., Peterlin, B.M., Hunt, C.A., (1997) Nucleic Acids Res., 25, pp. 575-581
Piva, R., Gambari, R., (1999) Minerva Biotecnologica, 11, pp. 193-203
Fraisier, C., Irvine, A., Wrighton, C., Craig, R., Dzierzak, E., (1998) Gene Ther., 5, pp. 1665-1676
Uhlmann, E., Peyman, A., (1990) Chem. Rev., 90, pp. 543-584
Nielsen, P.E., Egholm, M., Berg, R.H., Buchardt, O., (1991) Science, 254, pp. 1497-1500
Egholm, M., Buchardt, O., Christiensen, L., Behrens, C., Freier, S.M., Driver, D.A., Berg, R.H., Nielsen, P.E., (1993) Nature, 365, pp. 566-568
Betts, L., Josey, J.A., Veal, J.M., Jordan, S.R., (1995) Science, 270, pp. 1838-1841
Hanvey, J.C., Peffer, N.J., Bisi, J.E., Thomson, S.A., Cadilla, R., Josey, J.A., Ricca, D.J., Babiss, L.E., (1992) Science, 258, pp. 1481-1485
Demidov, V.V., Yavnilovich, M.V., Belotserkovskii, B.P., Frank-Kamenetskii, M.D., Nielsen, P.E., (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 2637-2641
Larsen, H.J., Nielsen, P.E., (1996) Nucleic Acids Res., 24, pp. 458-463
Demidov, V.V., Potaman, V.N., Frank-Kamenetskii, M.D., Egholm, M., Buchard, O., Sonnichsen, S.H., Nielsen, P.E., (1994) Biochem. Pharmacol., 48, pp. 1310-1313
Mischiati, C., Borgatti, M., Bianchi, N., Rutigliano, C., Tomassetti, M., Feriotto, G., Gambari, R., (1999) JBC, 274, pp. 33114-33122
Cramer, P., Larson, C.J., Verdine, G.L., Müller, C.W., (1997) Embo J., 16, pp. 7078-7090
Chen, F.E., Huang, D., Chen, Y., Ghosh, G., (1998) Nature, 391, pp. 410-413
Ghost, G., Van Duyne, G., Ghosh, S., Sigler, P.B., (1995) Nature, 373, pp. 303-310
Müller, C.W., Rey, F.A., Sodeoka, M., Verdine, G.L., Harrison, S.C., (1995) Nature, 373, pp. 311-317
Barbieri, R., Giacomini, P., Volinia, S., Nastruzzi, C., Mileo, A.M., Ferrini, U., Soria, M., Gambari, R., (1990) FEBS Lett., 268, pp. 51-54
Sagami, I., Tsai, S.Y., Wang, H., Tsai, M.J., O'Malley, B.W., (1986) Mol. Cell. Biol., 6, pp. 4259-4267
Saviano, M., Aida, M., Corongiu, G., (1991) Biopolymers, 31, pp. 1017-1024
Sen, S., Nilsson, L., (1998) J. Am. Chem. Soc., 120, pp. 619-631
Bianchi, N., Passadore, M., Rutigliano, C., Feriotto, G., Mischiati, C., Gambari, R., (1996) Biochem. Pharmacol., 52, pp. 1489-1498
Dignam, J.D., Lebovitz, R.M., Roeder, R.G., (1983) Nucleic Acids Res., 11, pp. 1475-1489
Soliva, R., Sherer, E., Luque, F.J., Laughton, C.A., Orozco, M., (2000) J. Am. Chem. Soc., 122, pp. 5997-6008
Finn, P.J., Gibson, N.J., Fallon, R., Hamilton, A., Brown, T., (1996) Nucleic Acids Res., 24, pp. 3357-3363
Sforza, S., Corradini, R., Galaverna, G., Dossena, A., Marchelli, R., (1999) Minerva Biotecnologica, 11, pp. 163-174
Van der Laan, A.C., Van Amsterdam, I., Tesser, G.I., Van Boom, J.H., Kuyl-Yeheskiely, E., (1998) Nucleosides and Nucleotides, 17, pp. 219-231
Berg, O. G., Von Hippel, P. H., (1988) Trends Biochem. Sci., 13, pp. 207-21
Mitchell, P. J., Tjian, R., (1989) Science, 2, pp. 371-378
Lim, C. S., Jabrane-Ferrat, N., Fontes, J. D., Okamoto, H., Garovoy, M. R., Peterlin, B. M., Hunt, C. A., (1997) Nucleic Acids Res., 25, pp. 575-581
Nielsen, P. E., Egholm, M., Berg, R. H., Buchardt, O., (1991) Science, 254, pp. 1497-1500
Hanvey, J. C., Peffer, N. J., Bisi, J. E., Thomson, S. A., Cadilla, R., Josey, J. A., Ricca, D. J., Babiss, L. E., (1992) Science, 258, pp. 1481-1485
Demidov, V. V., Yavnilovich, M. V., Belotserkovskii, B. P., Frank-Kamenetskii, M. D., Nielsen, P. E., (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 2637-2641
Larsen, H. J., Nielsen, P. E., (1996) Nucleic Acids Res., 24, pp. 458-463
Demidov, V. V., Potaman, V. N., Frank-Kamenetskii, M. D., Egholm, M., Buchard, O., Sonnichsen, S. H., Nielsen, P. E., (1994) Biochem. Pharmacol., 48, pp. 1310-1313
Chen, F. E., Huang, D., Chen, Y., Ghosh, G., (1998) Nature, 391, pp. 410-413
M ller, C. W., Rey, F. A., Sodeoka, M., Verdine, G. L., Harrison, S. C., (1995) Nature, 373, pp. 311-317
Dignam, J. D., Lebovitz, R. M., Roeder, R. G., (1983) Nucleic Acids Res., 11, pp. 1475-1489
Finn, P. J., Gibson, N. J., Fallon, R., Hamilton, A., Brown, T., (1996) Nucleic Acids Res., 24, pp. 3357-3363
Van der Laan, A. C., Van Amsterdam, I., Tesser, G. I., Van Boom, J. H., Kuyl-Yeheskiely, E., (1998) Nucleosides and Nucleotides, 17, pp. 219-231
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites
Peptide nucleic acids (PNA) have recently been proposed as alternative reagents in experiments aimed to the control of gene expression. In PNAs, the pseudopeptide backbone is composed of N-(2-aminoethyl)glycine units and therefore is stable in human serum and cellular extracts. PNAs hybridize with high affinity to complementary sequences of single-stranded RNA and DNA, forming Watson-Crick double helices and giving rise to highly stable (PNA)2-RNA triplexes with RNA targets. Therefore, antisense and antigéne PNAs have been synthetized and characterized. The major issue of the present paper is to describe some computational procedures useful to compare the behaviour of PNA double stranded molecules and PNA/DNA hybrids with the behaviour of regular DNA duplexes in generating complexes with DNA-binding proteins. The performed computational analyses clearly allow to predict that the lack of charged phosphate groups and the different shape of helix play a critical role in the binding efficiency of NF-κB transcription factors. These computational analyses are in agreement with competitive gel shift and UV-cross linking experiments. These experiments demonstrate that NF-κB PNA/PNA hybrids do not interact efficiently with proteins recognizing the NF-κB binding sites in genomic sequences. In addition, the data obtained indicate that the same NF-κB binding proteins recognize both the NF-κB DNA/PNA and DNA/DNA hybrids, but the molecular complexes generated with NF-κB DNA/PNA hybrids are less stable than those generated with NF-κB target DNA/DNA molecules.
Peptide nucleic acids (PNA) have recently been proposed as alternative reagents in experiments aimed to the control of gene expression. In PNAs, the pseudopeptide backbone is composed of N-(2-aminoethyl)glycine units and therefore is stable in human serum and cellular extracts. PNAs hybridize with high affinity to complementary sequences of single-stranded RNA and DNA, forming Watson-Crick double helices and giving rise to highly stable (PNA)2-RNA triplexes with RNA targets. Therefore, antisense and antigéne PNAs have been synthetized and characterized. The major issue of the present paper is to describe some computational procedures useful to compare the behaviour of PNA double stranded molecules and PNA/DNA hybrids with the behaviour of regular DNA duplexes in generating complexes with DNA-binding proteins. The performed computational analyses clearly allow to predict that the lack of charged phosphate groups and the different shape of helix play a critical role in the binding efficiency of NF-κB transcription factors. These computational analyses are in agreement with competitive gel shift and UV-cross linking experiments. These experiments demonstrate that NF-κB PNA/PNA hybrids do not interact efficiently with proteins recognizing the NF-κB binding sites in genomic sequences. In addition, the data obtained indicate that the same NF-κB binding proteins recognize both the NF-κB DNA/PNA and DNA/DNA hybrids, but the molecular complexes generated with NF-κB DNA/PNA hybrids are less stable than those generated with NF-κB target DNA/DNA molecules.
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites
| ▼ Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions |
| ▼ Molecular dynamics simulation approach to study UV-induced DNA damage |
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites
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Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
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Pensato S, Renda M, Leccia F, Saviano M, D'Andrea LD, Pedone C, Pedone PV, Romanelli A
* PNA zipper as a dimerization tool: development of a bZip mimic (514 views)
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Impact Factor: 2.572
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Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
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Impact Factor: 9.05
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
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Impact Factor: 6.908
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (410 views)
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Impact Factor: 0
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
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Impact Factor: 1.756
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Ruggiero A, Di Maro A, Severino V, Chambery A, Berisio R
* Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage (411 views)
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Impact Factor: 2.605
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
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Impact Factor: 5.155
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
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Impact Factor: 2.473
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (497 views)
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Impact Factor: 4.531
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Santoro F, Barone V, Improta R
* The Excited States Decay Of The A-T Dna: A Pcm/Td-Dft Study In Aqueous Solution Of The (9-Methyl-Adenine) 2 (1-Methyl-Thymine) 2 Stacked Tetramer (241 views)
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
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Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
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Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (584 views)
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Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
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Esposito S, Baglivo I, Malgieri G, Russo L, Zaccaro L, D'Andrea LD, Mammucari M, Di Blasio B, Isernia C, Fattorusso R, Pedone PV
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Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
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Impact Factor: 3.73
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Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
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Saviano M, Isernia C, Bassarello C, Di Lello P, Galdiero S, Mierke DF, Benedetti E, Pedone C
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Rivieccio V, Mannini R, Concilio L, D'Auria S, Pedone C, Grimaldi G
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
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Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
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Galdiero M, Vitiello M, Galdiero S
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Impact Factor: 1.932
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
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Impact Factor: 6.482
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
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Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV
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Impact Factor: 7.051
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
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Impact Factor: 3.542
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
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Impact Factor: 5.359
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
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Impact Factor: 2.849
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Fusion in Coq (479 views)
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Impact Factor: 0.415
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* Detection of small DNA fragments by biolayer interferometry (79 views)
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Impact Factor: 2.219
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Musumeci D, Roviello V, Roviello GN
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Impact Factor: 4.3
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Deiana M, Mettra B, Martinez-fernandez L, Mazur LM, Pawlik K, Andraud C, Samoc M, Improta R, Monnereau C, Matczyszyn K
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Impact Factor: 8.709
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Zhang Y, de La Harpe K, Beckstead AA, Improta R, Kohler B
* UV-Induced Proton Transfer between DNA Strands (388 views) (PDF 242 views)
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Impact Factor: 13.038
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
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Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
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Impact Factor: 3.341
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
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Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
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Impact Factor: 3.73
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (535 views)
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Impact Factor: 0
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Vitiello M, Galdiero M, Finamore E, Galdiero S, Galdiero M
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Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S
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Impact Factor: 3.463
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
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Impact Factor: 4.092
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
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Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, Falcone C, Fiume G, Gaspari M, Nevolo M, Di Salle E, Rossi A, De Laurentiis A, Greco A, Di Napoli D, Verheij E, Britti D, Lavecchia L, Quinto I, Scala G
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Impact Factor: 9.898
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
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Pedone E, Limauro D, D'Ambrosio K, De Simone G, Bartolucci S
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Impact Factor: 7.047
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (377 views)
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Impact Factor: 2.141
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Pensato S, Renda M, Leccia F, Saviano M, D'Andrea LD, Pedone C, Pedone PV, Romanelli A
* PNA zipper as a dimerization tool: development of a bZip mimic (514 views)
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Impact Factor: 2.572
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Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
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Impact Factor: 9.05
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (502 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (410 views)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
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Impact Factor: 1.756
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Ruggiero A, Di Maro A, Severino V, Chambery A, Berisio R
* Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage (411 views)
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Impact Factor: 2.605
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
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Impact Factor: 5.155
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
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Impact Factor: 2.473
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
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Impact Factor: 4.16
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (497 views)
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Impact Factor: 4.531
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Santoro F, Barone V, Improta R
* The Excited States Decay Of The A-T Dna: A Pcm/Td-Dft Study In Aqueous Solution Of The (9-Methyl-Adenine) 2 (1-Methyl-Thymine) 2 Stacked Tetramer (241 views)
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Impact Factor: 8.58
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1232 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
* The Prokaryotic Cys2his2 Zinc Finger Domain Adopts A Novel Fold As Revealed By The Solution Structure Of Agrobacterium Tumefaciens Ros Dna Binding Domain (462 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007 Oct 30; 104(44): 17341-17346.
Impact Factor: 9.598
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Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (584 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
Impact Factor: 3.446
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Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
* Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (348 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Impact Factor: 0.723
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Esposito S, Baglivo I, Malgieri G, Russo L, Zaccaro L, D'Andrea LD, Mammucari M, Di Blasio B, Isernia C, Fattorusso R, Pedone PV
* A novel type of zinc finger DNA binding domain in the Agrobacterium tumefaciens transcriptional regulator Ros (587 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Sep 29; 45(34): 10394-10405.
Impact Factor: 3.633
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Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
* Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (587 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 15; 62(3): 604-616.
Impact Factor: 3.73
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Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (520 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
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Saviano M, Isernia C, Bassarello C, Di Lello P, Galdiero S, Mierke DF, Benedetti E, Pedone C
* Conformational analysis by NMR and distance geometry techniques of a peptide mimetic of the third helix of the Antennapedia homeodomain (436 views)
J Pept Res (ISSN: 1397-002x), 2005 Feb; 65(2): 200-208.
Impact Factor: 1.741
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Rivieccio V, Mannini R, Concilio L, D'Auria S, Pedone C, Grimaldi G
* Expression, purification and partial characterization of the Krüppel-associated box (KRAB) from the human ZNF2 protein (314 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2005; 12(6): 527-532.
Impact Factor: 0.84
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (478 views)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (361 views)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Impact Factor: 1.567
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (312 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (491 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (538 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (372 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV
* The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys(2)-His(2) zinc finger motif (635 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2002 Nov 15; 30(22): 4945-4951.
Impact Factor: 7.051
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (416 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (670 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (431 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Fusion in Coq (479 views)
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596.
Impact Factor: 0.415
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51 Records (49 excluding Abstracts).
Total impact factor: 238.602 (234.872 excluding Abstracts).
Total 5 year impact factor: 246.266 (242.022 excluding Abstracts).
Total impact factor: 238.602 (234.872 excluding Abstracts).
Total 5 year impact factor: 246.266 (242.022 excluding Abstracts).
493 views. Last view on Saturday 04 March 2023, 19:22:44
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