Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, Catania, Italy
Dipartimento di Scienze della Salute, Università di Catanzaro, Campus Universitario, Viale Europa, 88100 Catanzaro, Italy
References: Rahuel-Clermont, S., French, C.A., Chou, C.I., Kaarsholm, N.C., Dunn, M.F., Mechanisms of stabilization of the insulin hexamer through allosteric ligand interactions (1997) Biochemistry, 36, pp. 5837-584
Garber, A.J., Pharmacologic modifications of hormones to improve their therapeutic potential for diabetes management (2005) Diabetes Obes. Metab., 7, pp. 666-674
Brange, J., Langkjaer, L., Insulin structure and stability (1993) Pharm. Biotechnol., 5, pp. 315-350
Mocchegiani, E., Giacconi, R., Malavolta, M., Zinc signalling and subcellular distribution: Emerging targets in type 2 diabetes (2008) Trends Mol. Med., 14, pp. 419-428
Roth, H., Kirchgessner, M., Zinc and insulin metabolism (1981) Biol. Trace Elem. Res., 3, pp. 13-32
Kinlaw, W.B., Levine, A.S., Morley, J.E., Silvis, S.E., McClain, C.J., Abnormal zinc metabolism in type II diabetes mellitus (1983) Am. J. Med., 75, pp. 273-277
Haase, H., Maret, W., Protein tyrosine phosphatases as targets of the combined insulinomimetic effects of zinc and oxidants (2005) Biometals, 18, pp. 333-338
Duckworth, W.C., Bennett, R.G., Hamel, F.G., Insulin degradation: Progress and potential (1998) Endocr. Rev., 19, pp. 608-624
Roth, R.A., Zhang, B., Chin, J.E., Kovacina, K., Substrates and signalling complexes: The tortured path to insulin action (1992) J. Cell. Biochem., 48, pp. 12-18
Peavy, D.E., Edmondson, J.W., Duckworth, W.C., Selective effects of inhibitors of hormone processing on insulin action in isolated hepatocytes (1984) Endocrinology, 114, pp. 753-760
Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E.A., Frosch, M.P., Eckman, C.B., Guénette, S., Insulin-degrading enzyme regulates the levels of insulin, amyloid -protein, and the -amyloid precursor protein intracellular domain in vivo (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 4162-4167
Becker, A.B., Roth, R.A., An unusual active site identified in a family of zinc metalloendopeptidases (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 3835-3839
Gehm, B.D., Rosner, M.R., Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes (1991) Endocrinology, 128, pp. 1603-1610
Kuo, W.L., Gehm, B.D., Rosner, M.R., Regulation of insulin degradation: Expression of an evolutionarily conserved insulin-degrading enzyme increases degradation via an intracellular pathway (1991) Mol. Endocrinol., 5, pp. 1467-1476
Amata, O., Marino, T., Russo, N., Toscano, M., Human insulin-degrading enzyme working mechanism (2009) J. Am. Chem. Soc., 131, pp. 14804-14811
Manolopoulou, M., Guo, Q., Malito, E., Schilling, A.B., Tang, W.-J., Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme (2009) J. Biol. Chem., 284, pp. 14177-14188
Grasso, G., Rizzarelli, E., Spoto, G., The proteolytic activity of insulin-degrading enzyme: A mass spectrometry study (2009) J. Mass Spectrom., 44, pp. 735-741
Hamel, F.G., Mahoney, M.J., Duckworth, W.C., Degradation of intraendosomal insulin by insulin degrading enzyme without acidification (1991) Diabetes, 40, pp. 436-443
Seabright, P.J., Smith, G.D., The characterization of endosomal insulin degradation intermediates and their sequence of production (1996) Biochem. J., 320, pp. 947-956
Authier, F., Metioui, M., Fabrega, S., Kouach, M., Briand, G., Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D (2002) J. Biol. Chem., 277, pp. 9437-9446
Hersh, L.B., The insulysin (insulin degrading enzyme) enigma (2006) Cell. Mol. Life Sci., 63, pp. 2432-2434
Duckworth, W.C., Fawcett, J., Tsui, B.T., Bennett, R.G., Hamel, F.G., Biological activity of a fragment of insulin (2004) Biochem. Biophys. Res. Comm., 318, pp. 1019-1024
Kikuchi, K., Larner, J., Freer, R., Day, A.R., Enhanced specific insulin binding and insulin action with C-terminal B-chain pentapeptide derived from insulin (1980) FEBS Lett., 119, pp. 161-164
Nakayama, M., Abiru, N., Moriyama, H., Babaya, N., Liu, E., Miao, D., Yu, L., Eisenbarth, G.S., Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice (2005) Nature, 435, pp. 220-223
Moriyama, H., Abiru, N., Paronen, J., Sikora, K., Liu, E., Miao, D., Devendra, D., Eisenbarth, G.S., Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 10376-10381
Daniel, D., Wegmann, D.R., Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23) (1996) Proc. Natl. Acad. Sci. USA, 93, pp. 956-960
Duckworth, W.C., Editorial: Increasing understanding of calmodulin- insulin interactions (1994) J. Lab. Clin. Med., 124, pp. 311-312
Grasso, G., Pietropaolo, A., Spoto, G., Pappalardo, G., Tundo, G.R., Ciaccio, C., Coletta, M., Rizzarelli, E., Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: Implications for metallostasis alteration in Alzheimer's disease (2011) Chem. Eur. J., 17, pp. 2752-2762
Hong, D.P., Ahmad, A., Fink, A.L., Fibrillation of human insulin A and B chains (2006) Biochemistry, 45, pp. 9342-9353
De Vries, S.J., Van Dijk, M., Bonvin, A.M.J.J., The HADDOCK web server for data-driven biomolecular docking (2010) Nat. Protoc., 5, pp. 883-897
Olsen, H.B., Ludvigsen, S., Kaarsholm, N.C., Solution structure of an engineered insulin monomer at neutral pH (1996) Biochemistry, 35, pp. 8836-8845
Garber, A. J., Pharmacologic modifications of hormones to improve their therapeutic potential for diabetes management (2005) Diabetes Obes. Metab., 7, pp. 666-674
Kinlaw, W. B., Levine, A. S., Morley, J. E., Silvis, S. E., McClain, C. J., Abnormal zinc metabolism in type II diabetes mellitus (1983) Am. J. Med., 75, pp. 273-277
Duckworth, W. C., Bennett, R. G., Hamel, F. G., Insulin degradation: Progress and potential (1998) Endocr. Rev., 19, pp. 608-624
Roth, R. A., Zhang, B., Chin, J. E., Kovacina, K., Substrates and signalling complexes: The tortured path to insulin action (1992) J. Cell. Biochem., 48, pp. 12-18
Peavy, D. E., Edmondson, J. W., Duckworth, W. C., Selective effects of inhibitors of hormone processing on insulin action in isolated hepatocytes (1984) Endocrinology, 114, pp. 753-760
Becker, A. B., Roth, R. A., An unusual active site identified in a family of zinc metalloendopeptidases (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 3835-3839
Gehm, B. D., Rosner, M. R., Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes (1991) Endocrinology, 128, pp. 1603-1610
Kuo, W. L., Gehm, B. D., Rosner, M. R., Regulation of insulin degradation: Expression of an evolutionarily conserved insulin-degrading enzyme increases degradation via an intracellular pathway (1991) Mol. Endocrinol., 5, pp. 1467-1476
Hamel, F. G., Mahoney, M. J., Duckworth, W. C., Degradation of intraendosomal insulin by insulin degrading enzyme without acidification (1991) Diabetes, 40, pp. 436-443
Seabright, P. J., Smith, G. D., The characterization of endosomal insulin degradation intermediates and their sequence of production (1996) Biochem. J., 320, pp. 947-956
Hersh, L. B., The insulysin (insulin degrading enzyme) enigma (2006) Cell. Mol. Life Sci., 63, pp. 2432-2434
Duckworth, W. C., Fawcett, J., Tsui, B. T., Bennett, R. G., Hamel, F. G., Biological activity of a fragment of insulin (2004) Biochem. Biophys. Res. Comm., 318, pp. 1019-1024
Duckworth, W. C., Editorial: Increasing understanding of calmodulin- insulin interactions (1994) J. Lab. Clin. Med., 124, pp. 311-312
Hong, D. P., Ahmad, A., Fink, A. L., Fibrillation of human insulin A and B chains (2006) Biochemistry, 45, pp. 9342-9353
De Vries, S. J., Van Dijk, M., Bonvin, A. M. J. J., The HADDOCK web server for data-driven biomolecular docking (2010) Nat. Protoc., 5, pp. 883-897
Olsen, H. B., Ludvigsen, S., Kaarsholm, N. C., Solution structure of an engineered insulin monomer at neutral pH (1996) Biochemistry, 35, pp. 8836-8845
Formation of insulin fragments by insulin-degrading enzyme: The role of zinc(II) and cystine bridges