CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (409 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.319, 5-year impact factor: 2.467
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84920388315&partnerID=40&md5=2318b8baf1505e0caaaae45779b9fb85
Keywords: Cholecystokinin Octapeptide, Cisplatin, Dibromo[ethyl N (dithiocarboxy) N Methylglycinato]gold, Gold Complex, Phosphate Buffered Saline, Poloxamer, Sodium Chloride, Unclassified Drug, Antineoplastic Activity, Aqueous Solution, Article, Cell Proliferation, Concentration Response, Controlled Study, Dialysis Membrane, Drug Cytotoxicity, Drug Delivery System, Drug Determination, Drug Formulation, Drug Potency, Drug Protein Binding, Drug Purification, Drug Selectivity, Drug Solubility, Drug Stability, Drug Synthesis, Drug Targeting, Fluorescence Spectroscopy, Genetic Transfection, Human, Human Cell, Hydrophilicity, In Vitro Study, Lipophilicity, Mathematical Computing, Mathematical Model, Micelle, Micellization, Nanoencapsulation, Oxidation, Peptide Analysis, Peptide Synthesis, Timed Drug Release, Dibromo [ethyl N (dithiocarboxy) N Methylglycinato] Gold,
Affiliations:
*** IBB - CNR ***
University of Padova, Department of Chemical Sciences, Via Marzolo 1Padova, Italy
University of Naples Federico II, Department of Pharmacy, CIRPeB and IBB CNR, Via Mezzocannone 16Naples, Italy
References:
Nagy, E.M., Ronconi, L., Nardon, C., Fregona, D., Noble metal-dithiocarbamates precious allies in the fight against cancer (2012) Mini-Rev. Med. Chem., 12, pp. 1216-122
Nardon, C., Boscutti, G., Fregona, D., Beyond platinums: Gold complexes as anticancer agents (2014) Anticancer Res., 34, pp. 487-492
Dalla Via, L., Nardon, C., Fregona, D., Targeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer. A challenge for the future (2012) Future Med. Chem., 4, pp. 525-543
Nagy, E.M., Nardon, C., Giovagnini, L., Marchiò, L., Trevisan, A., Fregona, D., Promising anticancer mono- and dinuclear ruthenium(iii) dithiocarbamato complexes: Systematic solution studies (2011) Dalton Trans., 40, pp. 11885-11895
Hincal, A.A., Long, D.F., Repta, A.J., Cis-platin stability in aqueous parenteral vehicles (1979) J. Parenter. Drug Assoc., 33, pp. 107-116
Lafollette, J.M., Arbus, M.H., Lauper, R.D., Stability of cisplatin admixtures in polyvinyl chloride bags (1985) Am. J. Hosp. Pharm., 42, p. 2652
Riley, C.M., Sternson, L.A., Cisplatin (1985) Anal. Profiles Drug Subst. Excipients, 14, pp. 77-105
Casini, A., Kelter, G., Gabbiani, C., Cinellu, M.A., Minghetti, G., Fregona, D., Fiebig, H., Messori, L., Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(iii) compounds for cancer treatment: A systematic study (2009) JBIC, J. Biol. Inorg. Chem., 14, pp. 1139-1149
Marzano, C., Ronconi, L., Chiara, F., Giron, M.C., Faustinelli, I., Cristofori, P., Trevisan, A., Fregona, D., Gold(iii)-dithiocarbamato anticancer agents: Activity, toxicology and histopathological studies in rodents (2011) Int. J. Cancer, 129, pp. 487-496
Cattaruzza, L., Fregona, D., Mongiat, M., Ronconi, L., Fassina, A., Colombatti, A., Aldinucci, D., Antitumor activity of gold(iii)-dithiocarbamato derivatives on prostate cancer cells and xenografts (2011) Int. J. Cancer, 128, pp. 206-215
Zhang, X., Frezza, M., Milacic, V., Ronconi, L., Fan, Y., Bi, C., Fregona, D., Dou, Q.P., Inhibition of tumor proteasome activity by gold-dithiocarbamato complexes via both redox-dependent and -independent processes (2010) J. Cell. Biochem., 109, pp. 162-172
Basak, R., Bandyopadhyay, R., Encapsulation of hydrophobic drugs in pluronic F127 micelles: Effects of drug hydrophobicity, solution temperature, and pH (2013) Langmuir, 29, pp. 4350-4356
Chiappetta, D.A., Sosnik, A., Poly(ethylene oxide)-poly(propylene oxide) block copolymer micelles as drug delivery agents: Improved hydrosolubility, stability and bioavailability of drugs (2007) Eur. J. Pharm. Biopharm., 66, pp. 303-317
Grindel, J.M., Jaworski, T., Piraner, O., Emanuele, R.M., Balasubramanian, M., Distribution, metabolism, and excretion of a novel surface-active agent, purified poloxamer 188, in rats, dogs, and humans (2002) J. Pharm. Sci., 91, pp. 1936-1947
Batrakova, E., Lee, S., Li, S., Venne, A., Alakhov, V., Kabanov, A., Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells (1999) Pharm. Res., 16, pp. 1373-1379
Reubi, J.C., Schaer, J., Waser, B., Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res., 57, pp. 1377-1386
Wank, S.A., Pisegna, J.R., De Weerth, A., Brain and gastrointestinal cholecystokinin receptor family: Structure and functional expression (1992) Proc. Natl. Acad. Sci. U. S. A., 89, pp. 8691-8695
Wank, S.A., G protein-coupled receptors in gastrointestinal physiology I. CCK receptors: An exemplary family (1998) Am. J. Physiol., 274, pp. G607-G613
Reubi, J.C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr. Rev., 24, pp. 389-427
Reubi, J.C., Waser, B., Concomitant expression of several peptide receptors in neuroendocrine tumours: Molecular basis for in vivo multireceptor tumour targeting (2003) Eur. J. Nucl. Med. Mol. Imaging, 30, pp. 781-793
Imdahl, A., Mantamadiotis, T., Eggstein, S., Farthmann, E.H., Baldwin, G.S., Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas (1995) J. Cancer Res. Clin. Oncol., 121, pp. 661-666
Aloj, L., Panico, M., Caracò, C., Del Vecchio, S., Arra, C., Affuso, A., Accardo, A., Salvatore, M., In Vitro and in Vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (2004) Cancer Biother.Radiopharm., 19, pp. 93-98
Benedetti, E., Morelli, G., Accardo, A., Mansi, R., Tesauro, D., Aloj, L., Criteria for the design and biological characterization of radiolabeled peptide-based pharmaceuticals (2004) BioDrugs, 18, pp. 279-295
Accardo, A., Morisco, A., Palladino, P., Palumbo, R., Tesauro, D., Morelli, G., Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (2011) Mol. BioSyst., 7, pp. 862-870
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (2007) ChemPhysChem, 8, pp. 2526-2538
Schmitt, L., Dietric, C., Tampé, R., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Morisco, A., Accardo, A., Gianolio, E., Tesauro, D., Benedetti, E., Morelli, G., Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (2009) J. Pept. Sci., 15, pp. 242-250
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Ronconi, L., Giovagnini, L., Marzano, C., Bettìo, F., Graziani, R., Pilloni, G., Fregona, D., Gold dithiocarbamate derivatives as potential antineoplastic agents: Design, spectroscopic properties, and in vitro antitumor activity (2005) Inorg. Chem., 44, pp. 1867-1881
Chen, L., Sha, X., Jiang, X., Chen, Y., Ren, Q., Fang, X., Pluronic P105/F127 mixed micelles for the delivery of docetaxel against Taxol-resistant non-small cell lung cancer: Optimization and in vitro, in vivo evaluation (2013) Int. J. Nanomed., 8, pp. 73-84
Dalla Via, L., Di Noto, V., Gia, O., Marciani Magno, S., Photoaddition of thienocoumarin derivatives to DNA: Stoichiometry and kinetics of binding (2005) J. Photochem. Photobiol., B, 79, pp. 59-65
Aloj, L., Caracò, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-b receptor imaging (2004) J. Nucl. Med., 45, pp. 485-494
Wei, Z., Yuan, S., Chen, Y., Yu, S., Hao, J., Luo, J., Sha, X., Fang, X., Enhanced antitumor efficacy by paclitaxel-loaded Pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance (2010) Eur. J. Pharm. Biopharm., 75, pp. 341-353
Sharma, P.K., Bhatia, S.R., Effect of anti-inflammatories on Pluronic® F127: Micellar assembly, gelation and partitioning (2004) Int. J. Pharm., 278, pp. 361-377
Ronconi, L., Marzano, C., Zanello, P., Corsini, M., Miolo, G., Maccà, C., Trevisan, A., Fregona, D., Gold(iii) dithiocarbamate derivatives for the treatment of cancer: Solution chemistry, DNA binding, and hemolytic properties (2006) J. Med. Chem., 49, pp. 1648-1657
Ronconi, L., Fregona, D., The Midas touch in cancer chemotherapy: From platinum- to gold-dithiocarbamato complexes (2009) Dalton Trans., pp. 10670-10680
Messori, L., Abbate, F., Marcon, G., Orioli, P., Fontani, M., Mini, E., Mazzei, T., Zanello, P., Gold(iii) complexes as potential antitumor agents: Solution chemistry and cytotoxic properties of some selected gold(iii) compounds (2000) J. Med. Chem., 43, pp. 3541-3548
Marcon, G., Carotti, S., Coronnello, M., Messori, L., Mini, E., Orioli, L., Mazzei, T., Minghetti, G., Gold(iii) complexes with bipyridyl ligands: Solution chemistry, cytotoxicity, and DNA binding properties (2002) J. Med. Chem., 45, pp. 1672-1677
Franchini, G.C., Giusti, A., Preti, C., Tassi, L., Zannini, P., Coordinating ability of methylpiperidine dithiocarbamates towards platinum group metals (1985) Polyhedron, 4, pp. 1553-1558
Hadjikostas, C.C., Katsoulos, G.A., Shakhatreh, S.K., Synthesis and spectral studies of some new palladium(II) and platinum(II) dithiocarbimato complexes. Reactions of bases with the corresponding N-alkyldithiocarbamates (1987) Inorg. Chim. Acta, 133, pp. 129-132
Roettger, B.F., Rentsch, R.U., Pinon, D., Holicky, E., Hadac, E., Larkin, J.M., Miller, L.J., Dual pathways of internalization of the cholecystokinin receptor (1995) J. Cell Biol., 128, pp. 1029-1041
Kouodom, M.N., Ronconi, L., Celegato, M., Nardon, C., Marchiò, L., Dou, Q.P., Aldinucci, D., Fregona, D., Toward the selective delivery of chemotherapeutics into tumor cells by targeting peptide transporters: Tailored gold-based anticancer peptidomimetics (2012) J. Med. Chem., 55, pp. 2212-2226
Nardon, C., Schmitt, S.M., Yang, H., Zuo, J., Fregona, D., Dou, Q.P., Gold(iii)-Dithiocarbamato Peptidomimetics in the Forefront of the Targeted Anticancer Therapy: Preclinical Studies against Human Breast Neoplasia (2014) PLoS One, 9 (1), p. e84248
Fregona, D., Ronconi, L., Formaggio, F., Dou, Q.P., Aldinucci, D., Gold(iii) complexes with oligopeptides functionalized with sulfur donors and use thereof as antitumor agents (2009) PCT Int. Appl., , 2009-EP53296
2009-EP53296 (WO2010105691): 34
Nagy, E. M., Ronconi, L., Nardon, C., Fregona, D., Noble metal-dithiocarbamates precious allies in the fight against cancer (2012) Mini-Rev. Med. Chem., 12, pp. 1216-122
Nagy, E. M., Nardon, C., Giovagnini, L., Marchi, L., Trevisan, A., Fregona, D., Promising anticancer mono- and dinuclear ruthenium (iii) dithiocarbamato complexes: Systematic solution studies (2011) Dalton Trans., 40, pp. 11885-11895
Hincal, A. A., Long, D. F., Repta, A. J., Cis-platin stability in aqueous parenteral vehicles (1979) J. Parenter. Drug Assoc., 33, pp. 107-116
Lafollette, J. M., Arbus, M. H., Lauper, R. D., Stability of cisplatin admixtures in polyvinyl chloride bags (1985) Am. J. Hosp. Pharm., 42, p. 2652
Riley, C. M., Sternson, L. A., Cisplatin (1985) Anal. Profiles Drug Subst. Excipients, 14, pp. 77-105
Chiappetta, D. A., Sosnik, A., Poly (ethylene oxide) -poly (propylene oxide) block copolymer micelles as drug delivery agents: Improved hydrosolubility, stability and bioavailability of drugs (2007) Eur. J. Pharm. Biopharm., 66, pp. 303-317
Grindel, J. M., Jaworski, T., Piraner, O., Emanuele, R. M., Balasubramanian, M., Distribution, metabolism, and excretion of a novel surface-active agent, purified poloxamer 188, in rats, dogs, and humans (2002) J. Pharm. Sci., 91, pp. 1936-1947
Reubi, J. C., Schaer, J., Waser, B., Cholecystokinin (CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res., 57, pp. 1377-1386
Wank, S. A., Pisegna, J. R., De Weerth, A., Brain and gastrointestinal cholecystokinin receptor family: Structure and functional expression (1992) Proc. Natl. Acad. Sci. U. S. A., 89, pp. 8691-8695
Wank, S. A., G protein-coupled receptors in gastrointestinal physiology I. CCK receptors: An exemplary family (1998) Am. J. Physiol., 274, pp. G607-G613
Reubi, J. C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr. Rev., 24, pp. 389-427
Reubi, J. C., Waser, B., Concomitant expression of several peptide receptors in neuroendocrine tumours: Molecular basis for in vivo multireceptor tumour targeting (2003) Eur. J. Nucl. Med. Mol. Imaging, 30, pp. 781-793
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Aloj, L., Carac, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-b receptor imaging (2004) J. Nucl. Med., 45, pp. 485-494
Sharma, P. K., Bhatia, S. R., Effect of anti-inflammatories on Pluronic F127: Micellar assembly, gelation and partitioning (2004) Int. J. Pharm., 278, pp. 361-377
Franchini, G. C., Giusti, A., Preti, C., Tassi, L., Zannini, P., Coordinating ability of methylpiperidine dithiocarbamates towards platinum group metals (1985) Polyhedron, 4, pp. 1553-1558
Hadjikostas, C. C., Katsoulos, G. A., Shakhatreh, S. K., Synthesis and spectral studies of some new palladium (II) and platinum (II) dithiocarbimato complexes. Reactions of bases with the corresponding N-alkyldithiocarbamates (1987) Inorg. Chim. Acta, 133, pp. 129-132
Roettger, B. F., Rentsch, R. U., Pinon, D., Holicky, E., Hadac, E., Larkin, J. M., Miller, L. J., Dual pathways of internalization of the cholecystokinin receptor (1995) J. Cell Biol., 128, pp. 1029-1041
Kouodom, M. N., Ronconi, L., Celegato, M., Nardon, C., Marchi, L., Dou, Q. P., Aldinucci, D., Fregona, D., Toward the selective delivery of chemotherapeutics into tumor cells by targeting peptide transporters: Tailored gold-based anticancer peptidomimetics (2012) J. Med. Chem., 55, pp. 2212-2226
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.319, 5-year impact factor: 2.467
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84920388315&partnerID=40&md5=2318b8baf1505e0caaaae45779b9fb85
Keywords: Cholecystokinin Octapeptide, Cisplatin, Dibromo[ethyl N (dithiocarboxy) N Methylglycinato]gold, Gold Complex, Phosphate Buffered Saline, Poloxamer, Sodium Chloride, Unclassified Drug, Antineoplastic Activity, Aqueous Solution, Article, Cell Proliferation, Concentration Response, Controlled Study, Dialysis Membrane, Drug Cytotoxicity, Drug Delivery System, Drug Determination, Drug Formulation, Drug Potency, Drug Protein Binding, Drug Purification, Drug Selectivity, Drug Solubility, Drug Stability, Drug Synthesis, Drug Targeting, Fluorescence Spectroscopy, Genetic Transfection, Human, Human Cell, Hydrophilicity, In Vitro Study, Lipophilicity, Mathematical Computing, Mathematical Model, Micelle, Micellization, Nanoencapsulation, Oxidation, Peptide Analysis, Peptide Synthesis, Timed Drug Release, Dibromo [ethyl N (dithiocarboxy) N Methylglycinato] Gold,
Affiliations:
*** IBB - CNR ***
University of Padova, Department of Chemical Sciences, Via Marzolo 1Padova, Italy
University of Naples Federico II, Department of Pharmacy, CIRPeB and IBB CNR, Via Mezzocannone 16Naples, Italy
References:
Nagy, E.M., Ronconi, L., Nardon, C., Fregona, D., Noble metal-dithiocarbamates precious allies in the fight against cancer (2012) Mini-Rev. Med. Chem., 12, pp. 1216-122
Nardon, C., Boscutti, G., Fregona, D., Beyond platinums: Gold complexes as anticancer agents (2014) Anticancer Res., 34, pp. 487-492
Dalla Via, L., Nardon, C., Fregona, D., Targeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer. A challenge for the future (2012) Future Med. Chem., 4, pp. 525-543
Nagy, E.M., Nardon, C., Giovagnini, L., Marchiò, L., Trevisan, A., Fregona, D., Promising anticancer mono- and dinuclear ruthenium(iii) dithiocarbamato complexes: Systematic solution studies (2011) Dalton Trans., 40, pp. 11885-11895
Hincal, A.A., Long, D.F., Repta, A.J., Cis-platin stability in aqueous parenteral vehicles (1979) J. Parenter. Drug Assoc., 33, pp. 107-116
Lafollette, J.M., Arbus, M.H., Lauper, R.D., Stability of cisplatin admixtures in polyvinyl chloride bags (1985) Am. J. Hosp. Pharm., 42, p. 2652
Riley, C.M., Sternson, L.A., Cisplatin (1985) Anal. Profiles Drug Subst. Excipients, 14, pp. 77-105
Casini, A., Kelter, G., Gabbiani, C., Cinellu, M.A., Minghetti, G., Fregona, D., Fiebig, H., Messori, L., Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(iii) compounds for cancer treatment: A systematic study (2009) JBIC, J. Biol. Inorg. Chem., 14, pp. 1139-1149
Marzano, C., Ronconi, L., Chiara, F., Giron, M.C., Faustinelli, I., Cristofori, P., Trevisan, A., Fregona, D., Gold(iii)-dithiocarbamato anticancer agents: Activity, toxicology and histopathological studies in rodents (2011) Int. J. Cancer, 129, pp. 487-496
Cattaruzza, L., Fregona, D., Mongiat, M., Ronconi, L., Fassina, A., Colombatti, A., Aldinucci, D., Antitumor activity of gold(iii)-dithiocarbamato derivatives on prostate cancer cells and xenografts (2011) Int. J. Cancer, 128, pp. 206-215
Zhang, X., Frezza, M., Milacic, V., Ronconi, L., Fan, Y., Bi, C., Fregona, D., Dou, Q.P., Inhibition of tumor proteasome activity by gold-dithiocarbamato complexes via both redox-dependent and -independent processes (2010) J. Cell. Biochem., 109, pp. 162-172
Basak, R., Bandyopadhyay, R., Encapsulation of hydrophobic drugs in pluronic F127 micelles: Effects of drug hydrophobicity, solution temperature, and pH (2013) Langmuir, 29, pp. 4350-4356
Chiappetta, D.A., Sosnik, A., Poly(ethylene oxide)-poly(propylene oxide) block copolymer micelles as drug delivery agents: Improved hydrosolubility, stability and bioavailability of drugs (2007) Eur. J. Pharm. Biopharm., 66, pp. 303-317
Grindel, J.M., Jaworski, T., Piraner, O., Emanuele, R.M., Balasubramanian, M., Distribution, metabolism, and excretion of a novel surface-active agent, purified poloxamer 188, in rats, dogs, and humans (2002) J. Pharm. Sci., 91, pp. 1936-1947
Batrakova, E., Lee, S., Li, S., Venne, A., Alakhov, V., Kabanov, A., Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells (1999) Pharm. Res., 16, pp. 1373-1379
Reubi, J.C., Schaer, J., Waser, B., Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res., 57, pp. 1377-1386
Wank, S.A., Pisegna, J.R., De Weerth, A., Brain and gastrointestinal cholecystokinin receptor family: Structure and functional expression (1992) Proc. Natl. Acad. Sci. U. S. A., 89, pp. 8691-8695
Wank, S.A., G protein-coupled receptors in gastrointestinal physiology I. CCK receptors: An exemplary family (1998) Am. J. Physiol., 274, pp. G607-G613
Reubi, J.C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr. Rev., 24, pp. 389-427
Reubi, J.C., Waser, B., Concomitant expression of several peptide receptors in neuroendocrine tumours: Molecular basis for in vivo multireceptor tumour targeting (2003) Eur. J. Nucl. Med. Mol. Imaging, 30, pp. 781-793
Imdahl, A., Mantamadiotis, T., Eggstein, S., Farthmann, E.H., Baldwin, G.S., Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas (1995) J. Cancer Res. Clin. Oncol., 121, pp. 661-666
Aloj, L., Panico, M., Caracò, C., Del Vecchio, S., Arra, C., Affuso, A., Accardo, A., Salvatore, M., In Vitro and in Vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (2004) Cancer Biother.Radiopharm., 19, pp. 93-98
Benedetti, E., Morelli, G., Accardo, A., Mansi, R., Tesauro, D., Aloj, L., Criteria for the design and biological characterization of radiolabeled peptide-based pharmaceuticals (2004) BioDrugs, 18, pp. 279-295
Accardo, A., Morisco, A., Palladino, P., Palumbo, R., Tesauro, D., Morelli, G., Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (2011) Mol. BioSyst., 7, pp. 862-870
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (2007) ChemPhysChem, 8, pp. 2526-2538
Schmitt, L., Dietric, C., Tampé, R., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Morisco, A., Accardo, A., Gianolio, E., Tesauro, D., Benedetti, E., Morelli, G., Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (2009) J. Pept. Sci., 15, pp. 242-250
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Ronconi, L., Giovagnini, L., Marzano, C., Bettìo, F., Graziani, R., Pilloni, G., Fregona, D., Gold dithiocarbamate derivatives as potential antineoplastic agents: Design, spectroscopic properties, and in vitro antitumor activity (2005) Inorg. Chem., 44, pp. 1867-1881
Chen, L., Sha, X., Jiang, X., Chen, Y., Ren, Q., Fang, X., Pluronic P105/F127 mixed micelles for the delivery of docetaxel against Taxol-resistant non-small cell lung cancer: Optimization and in vitro, in vivo evaluation (2013) Int. J. Nanomed., 8, pp. 73-84
Dalla Via, L., Di Noto, V., Gia, O., Marciani Magno, S., Photoaddition of thienocoumarin derivatives to DNA: Stoichiometry and kinetics of binding (2005) J. Photochem. Photobiol., B, 79, pp. 59-65
Aloj, L., Caracò, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-b receptor imaging (2004) J. Nucl. Med., 45, pp. 485-494
Wei, Z., Yuan, S., Chen, Y., Yu, S., Hao, J., Luo, J., Sha, X., Fang, X., Enhanced antitumor efficacy by paclitaxel-loaded Pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance (2010) Eur. J. Pharm. Biopharm., 75, pp. 341-353
Sharma, P.K., Bhatia, S.R., Effect of anti-inflammatories on Pluronic® F127: Micellar assembly, gelation and partitioning (2004) Int. J. Pharm., 278, pp. 361-377
Ronconi, L., Marzano, C., Zanello, P., Corsini, M., Miolo, G., Maccà, C., Trevisan, A., Fregona, D., Gold(iii) dithiocarbamate derivatives for the treatment of cancer: Solution chemistry, DNA binding, and hemolytic properties (2006) J. Med. Chem., 49, pp. 1648-1657
Ronconi, L., Fregona, D., The Midas touch in cancer chemotherapy: From platinum- to gold-dithiocarbamato complexes (2009) Dalton Trans., pp. 10670-10680
Messori, L., Abbate, F., Marcon, G., Orioli, P., Fontani, M., Mini, E., Mazzei, T., Zanello, P., Gold(iii) complexes as potential antitumor agents: Solution chemistry and cytotoxic properties of some selected gold(iii) compounds (2000) J. Med. Chem., 43, pp. 3541-3548
Marcon, G., Carotti, S., Coronnello, M., Messori, L., Mini, E., Orioli, L., Mazzei, T., Minghetti, G., Gold(iii) complexes with bipyridyl ligands: Solution chemistry, cytotoxicity, and DNA binding properties (2002) J. Med. Chem., 45, pp. 1672-1677
Franchini, G.C., Giusti, A., Preti, C., Tassi, L., Zannini, P., Coordinating ability of methylpiperidine dithiocarbamates towards platinum group metals (1985) Polyhedron, 4, pp. 1553-1558
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CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics
The bioavailability and target selectivity of chemotherapeutics are significant issues in drug development. Here, we report the loading of the antiproliferative gold(iii) complex, dibromo[ethyl-N-(dithiocarboxy-kS,kS′)-N-methylglycinato] gold(iii) (AuL12), into the lipophilic core of micelles produced from the surfactant Pluronic® F127 (PF127). When AuL12 is encapsulated in PF127-based micelles it remains stable in saline solution up to 72 h with the gold center in the +3 oxidation state. PF127-based aggregates are efficient carriers as they enhance the water solubility of the gold complex. In vitro studies indicate that after micelle encapsulation, AuL12 gold complex preserves its antiproliferative efficacy. Moreover, by labeling the hydrophilic shell of micelles with the bioactive CCK8 peptide, the aggregates act as target-selective vehicles. In fact, cytotoxic activity towards the A431 cells overexpressing the CCK2 receptors is 10-fold higher than that towards the control cells. This journal is © The Royal Society of Chemistry.
The bioavailability and target selectivity of chemotherapeutics are significant issues in drug development. Here, we report the loading of the antiproliferative gold(iii) complex, dibromo[ethyl-N-(dithiocarboxy-kS,kS′)-N-methylglycinato] gold(iii) (AuL12), into the lipophilic core of micelles produced from the surfactant Pluronic® F127 (PF127). When AuL12 is encapsulated in PF127-based micelles it remains stable in saline solution up to 72 h with the gold center in the +3 oxidation state. PF127-based aggregates are efficient carriers as they enhance the water solubility of the gold complex. In vitro studies indicate that after micelle encapsulation, AuL12 gold complex preserves its antiproliferative efficacy. Moreover, by labeling the hydrophilic shell of micelles with the bioactive CCK8 peptide, the aggregates act as target-selective vehicles. In fact, cytotoxic activity towards the A431 cells overexpressing the CCK2 receptors is 10-fold higher than that towards the control cells. This journal is © The Royal Society of Chemistry.
CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics
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CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics
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Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
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* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (616 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
View Export to BibTeX Export to EndNote
Pica A, Graziano G
* On the effect of sodium chloride and sodium sulfate on cold denaturation (307 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015; 10(7): N/D-N/D.
Impact Factor: 3.057
View Export to BibTeX Export to EndNote
Ferraro G, Massai L, Messori L, Cinellu MA, Merlino A
* Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme (360 views)
Biometals (ISSN: 0966-0844), 2015; 28(4): 745-754.
Impact Factor: 2.134
View Export to BibTeX Export to EndNote
Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (473 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
View Export to BibTeX Export to EndNote
Graziano G, Merlino A
* Molecular bases of protein halotolerance (363 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Apr; 1844(4): 850-858.
Impact Factor: 4.882
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Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F
* Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability (526 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1844(3): 632-640.
Impact Factor: 4.882
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Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
* Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (339 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014; 6(2): 233-236.
Impact Factor: 3.585
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Briganti F, Tedeschi E, Leone G, Marseglia M, Cicala D, Giamundo M, Napoli M, Caranci F
* Endovascular treatment of vertebro-vertebral arteriovenous fistula (381 views)
Neuroradiol J (ISSN: 1971-4009, 1971-4009print), 2013 Jun; 26(3): 339-346.
Impact Factor: 2.16
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Pica A, Russo Krauss I, Castellano I, La Cara F, Graziano G, Sica F, Merlino A
* Effect Of Nacl On The Conformational Stability Of The Thermophilic Gamma-Glutamyltranspeptidase From Geobacillus Thermodenitrificans: Implication For Globular Protein Halotolerance (334 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Jan; 1834(1): 149-157.
Impact Factor: 3.191
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Ascione G, de Pascale D, De Santi C, Pedone C, Dathan NA, Monti SM
* Native expression and purification of hormone-sensitive lipase from Psychrobacter sp. TA144 enhances protein stability and activity (509 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2012 Apr 13; 420(3): 542-546.
Impact Factor: 2.406
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Tornesello AL, Aurilio M, Accardo A, Tarallo L, Barbieri A, Arra C, Tesauro D, Morelli G, Aloj L
* Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (380 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 405-412.
Impact Factor: 1.799
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Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (492 views)
Mol Biosyst (ISSN: 1742-206x), 2011 Mar; 7(3): 862-870.
Impact Factor: 3.534
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Scudiero O, Galdiero S, Cantisani M, Di Noto R, Vitiello M, Galdiero M, Naclerio G, Cassiman JJ, Pedone C, Castaldo G, Salvatore F
* Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (555 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Impact Factor: 4.672
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Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
* Biochemical Characterisation Of The D60a Mutant Of The Elongation Factor 1 Alpha From The Archaeon Sulfolobus Solfataricus (307 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2009 Jul; 91(7): 835-842.
Impact Factor: 3.897
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Cirioni O, Ghiselli R, Orlando F, Silvestri C, De Luca S, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A
* Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis (315 views)
Critical Care Medicine (ISSN: 0090-3493), 2008 Sep; 36(9): 2629-2633.
Impact Factor: 6.594
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Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (402 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (394 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (391 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (400 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Ronga L, Palladino P, Tizzano B, Marasco D, Benedetti E, Ragone R, Rossi F
* Effect of salts on the structural behavior of hPrP α2-helix-derived analogues: The counterion perspective (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 790-795.
Impact Factor: 1.801
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De Luca S, Saviano M, Lassiani L, Yannakopoulou K, Stefanidou P, Aloj L, Morelli G, Varnavas A
* Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes" (438 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Apr 20; 49(8): 2456-2462.
Impact Factor: 5.115
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (359 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (452 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (587 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
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Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (519 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
Impact Factor: 1.091
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Romano M, Giojelli A, Tamburrini O, Salvatore M
* Chemoembolization for hepatocellular carcinoma: Effect of intraarterial lidocaine in peri- and post-procedural pain and hospitalization (424 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2003 Apr; 105(4): 350-355.
Impact Factor: 1.368
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De Luca S, Ragone R, Bracco C, Digilio G, Tesauro D, Saviano M, Pedone C, Morelli G
* The role of segment 32-47 of cholecystokinin receptor type A in CCK8 binding: Synthesis, nuclear magnetic resonance, circular dichroism and fluorescence studies (349 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Mar; 9(3): 156-169.
Impact Factor: 1.377
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Romano M, Giojelli A, Mainenti PP, Tamburrini O, Salvatore M
* Upper thoracic sympathetic chain neurolysis under CT guidance. A two year follow-up in patients with palmar and axillary hyperhidrosis (385 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2002 Nov; 104(5-6): 421-425.
Impact Factor: 1.368
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (323 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (496 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (443 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001 Jul; 7(7): 386-394.
Impact Factor: 1.451
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Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (419 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 47-53.
Impact Factor: 2.405
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42 Records (42 excluding Abstracts).
Total impact factor: 125.22 (125.22 excluding Abstracts).
Total 5 year impact factor: 133.56 (133.56 excluding Abstracts).
Total impact factor: 125.22 (125.22 excluding Abstracts).
Total 5 year impact factor: 133.56 (133.56 excluding Abstracts).
409 views. Last view on Monday 27 March 2023, 21:43:15
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