Solid phase synthesis of a novel folate-conjugated 5-aminolevulinic acid methyl ester based photosensitizer for selective photodynamic therapy(421 views) Guaragna A, Roviello GN, D'Errico S, Paolella C, Palumbo G, D'Alonzo D
Tetrahedron Lett (ISSN: 0040-4039), 2015 Feb 4; 56(6): 775-778.
Dipartimento di Scienze Chimiche, Università Degli Studi di Napoli Federico II, via Cintia 21Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16Napoli, Italy
Dipartimento di Farmacia, Università Degli Studi di Napoli Federico II, Via D. Montesano 49Napoli, Italy
Universita degli Studi di Napoli Federico II
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Solid phase synthesis of a novel folate-conjugated 5-aminolevulinic acid methyl ester based photosensitizer for selective photodynamic therapy
The development of a novel tumor-targeting photosensitizer delivery system, with potential ability to selectively transport the photosensitizer prodrug 5-aminolevulinic acid methyl ester (MAL) into the tumor site has been herein described. Conjugation of MAL to folic acid (FA) via an unnatural beta-peptide linker has been carried out almost entirely by an efficient solid phase approach. This molecular system has been devised for possible applications in selective photodynamic diagnosis (PDD) and therapy (PDT). (C) 2014 Elsevier Ltd. All rights reserved.
Solid phase synthesis of a novel folate-conjugated 5-aminolevulinic acid methyl ester based photosensitizer for selective photodynamic therapy
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Solid phase synthesis of a novel folate-conjugated 5-aminolevulinic acid methyl ester based photosensitizer for selective photodynamic therapy