Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (321 views)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.87, 5-year impact factor: 1.905
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-40849115098&partnerID=40&md5=38b452a633aa83d03ec7fcb0b380d67e
Keywords: Carbon Nanotubes, Cytotoxicity, Human Blood Cells, Metabolic Activity, Emerging Technologies, Human Health Risks, Human Peripheral Blood, Intracellular Drug Delivery, Optical Bio-Sensors, Toxicological Properties, Cell Death, Cell Growth, Growth Kinetics,
Affiliations:
*** IBB - CNR ***
Istituto per il Rilevamento Elettromagnetico Dell' Ambiente (IREA), CNR, Via Diocleziano, 328, 80124 Napoli, Italy
Istituto di Biostrutture e Bioimmagini (IBB), CNR, Via Mezzocannone, 16, 80137 Napoli, Italy
Seconda Universita degli Studi di Napoli, Dipartimento di Ingegneria Dell' Informazione (DII), Aversa, Italy
References:
Lin, Y., Taylor, S., Li, H., Fernando, S.K.A., Qu, L., Wang, W., Gu, L., Sun, Y.P., Advances towards bioapplications of carbon nanotubes (2004) J. Mater. Chem, 14, pp. 527-54
Hurt, R.H., Monthioux, M., Kane, A., Toxicology of carbon nanomaterials: Status, trends, and perspectives on the special issue (2006) Carbon, 44, pp. 1028-1033
Smart, S.K., Cassady, A.I., Lu, G.Q., Martin, D.J., The biocompatibility of carbon nanotubes (2006) Carbon, 44, pp. 1034-1047
Shvedova, A., Castranova, V., Kisin, E., Schwegler-Berry, D., Murray, A., Gandelsman, V., Maynard, A., Baron, P., Exposure to nanotube material: Assessment of nanotube cytotoxicity using human keratinocyte cells (2003) J. Toxicol. Environ. Health, 66, pp. 1901-1918
Monteiro-Riviere, N.A., Nemanich, R.J., Inman, A.O., Wang, Y.Y., Riviere, J.E., Multi-walled carbon nanotube interactions with human epidermal keratinocytes (2005) Toxicol. Lett, 155, pp. 377-384
Manna, S.K., Sarkar, S., Barr, J., Wisw, K., Barrera, E.V., Jejelowo, O., Rice-Ficht, A.C., Ramesh, J.T., Single-walled carbon nanotubes induces oxidative stress and activates nuclear transcription factor-kB in human keratinocytes (2005) Nano Lett, 5, pp. 1676-1684
Jia, G., Wang, H., Yan, L., Wang, X., Pei, R., Yan, T., Zhao, Y., Guo, X., Cytotoxicity of carbon nanomaterials: Single-wall nanotubes, multiwall nanotube, and fullerene (2005) Environ. Sci. Technol, 39, pp. 1378-1383
Ding, L., Stilwell, J., Zhang, T., Elboudwarej, O., Jang, H., Selegue, J.P., Cooke, P.A., Chen, F.F., Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast (2005) Nano Lett, 5, pp. 2448-2464
Muller, J., Huaux, F., Moreau, N., Misson, P., Heilier, J.F., Delos, M., Arras, M., Lison, D., Respiratory toxicity of multi-wall carbon nanotubes (2005) Toxicol. Appl. Pharmacol, 207, pp. 221-231
Bottini, M., Bruckner, S., Nika, K., Bottini, N., Bellocci, S., Magrini, A., Bergamaschi, A., Mustelin, T., Multi-walled carbon nanotubes induce T lymphocyte apoptosis (2006) Toxicol. Lett, 160, pp. 121-126
Boyum, A., Isolation of leukocytes from human blood. Further observations. Methylcellulose, dextran and ficoll as erythrocyte aggregation agents (1968) Scand. J. Clin. Lab. Invest, 97, pp. 31-50
Decker, T., Lohmann-Matthes, M.L., A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumour necrosis factor (TNF) activity (1988) J. Immunol. Methods, 115, pp. 61-69
Russo, M., Palumbo, R., Mupo, A., Tosto, M., Iacomino, G., Scognamiglio, A., Tedesco, I., Russo, G.L., Flavonoid quercetin sensitizes a CD95 resistant cell line to apoptosis by activating protein kinase Cα (2003) Oncogene, 22, pp. 3330-3342
O'Brien, J., Wilson, I., Orton, T., Pognan, F., Investigation of the Alamar blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity (2000) Eur. J. Biochem, 267, pp. 5421-5426
Singh, N.P., McCoy, M.T., Tice, R., Schneider, E.L., A simple technique for quantitation of low level of DNA damage in individual cells (1988) Exp. Cell. Res, 175, pp. 184-187
Messina, G.: Scarfi, M.R.. Cytogenetic observations in human peripheral blood leukocytes following in vitro exposure to THz radiation: a pilot study. Health Phys. 2007, 92, 349-357Riedl, S.J., Shi, Y., Molecular mechanisms of caspase regulation during apoptosis (2004) Nat. Rev. Mol. Cell Biol, 5, pp. 897-907
Zhang, H.X., Du, G.H., Zhang, J.T., Assay of mitochondrial functions by resazurin in vitro (2004) Acta Pharmacol. Sin, 25, pp. 385-389
Davoren, M., Herzog, E., Casey, A., Cottineau, B., Chambers, G., Byrne, H.J., Lyng, F.M., In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells (2007) Toxicol In Vitro, 21, pp. 438-448
Worle-Knirsch, J.M., Pulskamp, K., Krug, H.F., Oops they did it again! Carbon nanotubes hoax scientists in viability assays (2006) Nano Lett, 6, pp. 1261-1268
Casey, A., Herzog, E., Davoren, M., Lyng, F.M., Byrne, H.J., Chambers, G., Spectroscopic analysis confirms the interactions between single walled carbon nanotubes and various dye commonly used to assess cytotoxicity (2007) Carbon, 45, pp. 1425-1432
Speit, G., Agurell, E.
Hartmann, A. Fourth international workgroup on genotoxicity testing: results of the in vivo comet assay workshop. Mutat. Res. 2007, 627, 31-35Fairbairn, D.W., Olive, P.L., O'Neill, K.L., The comet assay: A comprehensive review (1995) Mutat. Res, 339, pp. 37-59
Rojas, E., Lopez, M.C., Malverde, M., Single cell gel electrophoresis assay: Methodology and applications (1999) J. Chromatogr, 722, pp. 225-254
Wick, P., Manser, P., Limbach, L.K., Dettlaff-Weglikowska, U., Krumeich, F., Roth, S., Stark, W.J., Bruinink, A., The degree and kind of agglomeration affect carbon nanotube cytotoxicity (2007) Toxicol. Lett, 168, pp. 121-131
Magrez, A., Kasa, S., Salicio, V., Pasquier, N., Seo, J.W., Celio, M., Catsicas, S., Forro, L., Cellular toxicity of carbon-based nanomaterilas (2006) Nano Lett, 6, pp. 1121-1125
Cui, D., Tian, F., Ozkan, C.S., Wang, M., Gao, H., Effect of single wall carbon nanotubes on human HEK293 cells (2005) Toxicol. Lett, 155, pp. 73-85
Pulskamp, K., Diabate, S., Krug, H.F., Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants (2007) Toxicol. Lett, 168, pp. 58-74
Garibaldi, S., Brunelli, C., Bavastrello, V., Ghigliotti, G., Nicolini, C., Carbon nanotube biocompatibility with cardiac muscle cells (2006) Nanotechnology, 17, pp. 391-397
Hurt, R. H., Monthioux, M., Kane, A., Toxicology of carbon nanomaterials: Status, trends, and perspectives on the special issue (2006) Carbon, 44, pp. 1028-1033
Smart, S. K., Cassady, A. I., Lu, G. Q., Martin, D. J., The biocompatibility of carbon nanotubes (2006) Carbon, 44, pp. 1034-1047
Manna, S. K., Sarkar, S., Barr, J., Wisw, K., Barrera, E. V., Jejelowo, O., Rice-Ficht, A. C., Ramesh, J. T., Single-walled carbon nanotubes induces oxidative stress and activates nuclear transcription factor-kB in human keratinocytes (2005) Nano Lett, 5, pp. 1676-1684
Singh, N. P., McCoy, M. T., Tice, R., Schneider, E. L., A simple technique for quantitation of low level of DNA damage in individual cells (1988) Exp. Cell. Res, 175, pp. 184-187
Zhang, H. X., Du, G. H., Zhang, J. T., Assay of mitochondrial functions by resazurin in vitro (2004) Acta Pharmacol. Sin, 25, pp. 385-389
Worle-Knirsch, J. M., Pulskamp, K., Krug, H. F., Oops they did it again! Carbon nanotubes hoax scientists in viability assays (2006) Nano Lett, 6, pp. 1261-1268
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.87, 5-year impact factor: 1.905
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-40849115098&partnerID=40&md5=38b452a633aa83d03ec7fcb0b380d67e
Keywords: Carbon Nanotubes, Cytotoxicity, Human Blood Cells, Metabolic Activity, Emerging Technologies, Human Health Risks, Human Peripheral Blood, Intracellular Drug Delivery, Optical Bio-Sensors, Toxicological Properties, Cell Death, Cell Growth, Growth Kinetics,
Affiliations:
*** IBB - CNR ***
Istituto per il Rilevamento Elettromagnetico Dell' Ambiente (IREA), CNR, Via Diocleziano, 328, 80124 Napoli, Italy
Istituto di Biostrutture e Bioimmagini (IBB), CNR, Via Mezzocannone, 16, 80137 Napoli, Italy
Seconda Universita degli Studi di Napoli, Dipartimento di Ingegneria Dell' Informazione (DII), Aversa, Italy
References:
Lin, Y., Taylor, S., Li, H., Fernando, S.K.A., Qu, L., Wang, W., Gu, L., Sun, Y.P., Advances towards bioapplications of carbon nanotubes (2004) J. Mater. Chem, 14, pp. 527-54
Hurt, R.H., Monthioux, M., Kane, A., Toxicology of carbon nanomaterials: Status, trends, and perspectives on the special issue (2006) Carbon, 44, pp. 1028-1033
Smart, S.K., Cassady, A.I., Lu, G.Q., Martin, D.J., The biocompatibility of carbon nanotubes (2006) Carbon, 44, pp. 1034-1047
Shvedova, A., Castranova, V., Kisin, E., Schwegler-Berry, D., Murray, A., Gandelsman, V., Maynard, A., Baron, P., Exposure to nanotube material: Assessment of nanotube cytotoxicity using human keratinocyte cells (2003) J. Toxicol. Environ. Health, 66, pp. 1901-1918
Monteiro-Riviere, N.A., Nemanich, R.J., Inman, A.O., Wang, Y.Y., Riviere, J.E., Multi-walled carbon nanotube interactions with human epidermal keratinocytes (2005) Toxicol. Lett, 155, pp. 377-384
Manna, S.K., Sarkar, S., Barr, J., Wisw, K., Barrera, E.V., Jejelowo, O., Rice-Ficht, A.C., Ramesh, J.T., Single-walled carbon nanotubes induces oxidative stress and activates nuclear transcription factor-kB in human keratinocytes (2005) Nano Lett, 5, pp. 1676-1684
Jia, G., Wang, H., Yan, L., Wang, X., Pei, R., Yan, T., Zhao, Y., Guo, X., Cytotoxicity of carbon nanomaterials: Single-wall nanotubes, multiwall nanotube, and fullerene (2005) Environ. Sci. Technol, 39, pp. 1378-1383
Ding, L., Stilwell, J., Zhang, T., Elboudwarej, O., Jang, H., Selegue, J.P., Cooke, P.A., Chen, F.F., Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast (2005) Nano Lett, 5, pp. 2448-2464
Muller, J., Huaux, F., Moreau, N., Misson, P., Heilier, J.F., Delos, M., Arras, M., Lison, D., Respiratory toxicity of multi-wall carbon nanotubes (2005) Toxicol. Appl. Pharmacol, 207, pp. 221-231
Bottini, M., Bruckner, S., Nika, K., Bottini, N., Bellocci, S., Magrini, A., Bergamaschi, A., Mustelin, T., Multi-walled carbon nanotubes induce T lymphocyte apoptosis (2006) Toxicol. Lett, 160, pp. 121-126
Boyum, A., Isolation of leukocytes from human blood. Further observations. Methylcellulose, dextran and ficoll as erythrocyte aggregation agents (1968) Scand. J. Clin. Lab. Invest, 97, pp. 31-50
Decker, T., Lohmann-Matthes, M.L., A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumour necrosis factor (TNF) activity (1988) J. Immunol. Methods, 115, pp. 61-69
Russo, M., Palumbo, R., Mupo, A., Tosto, M., Iacomino, G., Scognamiglio, A., Tedesco, I., Russo, G.L., Flavonoid quercetin sensitizes a CD95 resistant cell line to apoptosis by activating protein kinase Cα (2003) Oncogene, 22, pp. 3330-3342
O'Brien, J., Wilson, I., Orton, T., Pognan, F., Investigation of the Alamar blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity (2000) Eur. J. Biochem, 267, pp. 5421-5426
Singh, N.P., McCoy, M.T., Tice, R., Schneider, E.L., A simple technique for quantitation of low level of DNA damage in individual cells (1988) Exp. Cell. Res, 175, pp. 184-187
Messina, G.: Scarfi, M.R.. Cytogenetic observations in human peripheral blood leukocytes following in vitro exposure to THz radiation: a pilot study. Health Phys. 2007, 92, 349-357Riedl, S.J., Shi, Y., Molecular mechanisms of caspase regulation during apoptosis (2004) Nat. Rev. Mol. Cell Biol, 5, pp. 897-907
Zhang, H.X., Du, G.H., Zhang, J.T., Assay of mitochondrial functions by resazurin in vitro (2004) Acta Pharmacol. Sin, 25, pp. 385-389
Davoren, M., Herzog, E., Casey, A., Cottineau, B., Chambers, G., Byrne, H.J., Lyng, F.M., In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells (2007) Toxicol In Vitro, 21, pp. 438-448
Worle-Knirsch, J.M., Pulskamp, K., Krug, H.F., Oops they did it again! Carbon nanotubes hoax scientists in viability assays (2006) Nano Lett, 6, pp. 1261-1268
Casey, A., Herzog, E., Davoren, M., Lyng, F.M., Byrne, H.J., Chambers, G., Spectroscopic analysis confirms the interactions between single walled carbon nanotubes and various dye commonly used to assess cytotoxicity (2007) Carbon, 45, pp. 1425-1432
Speit, G., Agurell, E.
Hartmann, A. Fourth international workgroup on genotoxicity testing: results of the in vivo comet assay workshop. Mutat. Res. 2007, 627, 31-35Fairbairn, D.W., Olive, P.L., O'Neill, K.L., The comet assay: A comprehensive review (1995) Mutat. Res, 339, pp. 37-59
Rojas, E., Lopez, M.C., Malverde, M., Single cell gel electrophoresis assay: Methodology and applications (1999) J. Chromatogr, 722, pp. 225-254
Wick, P., Manser, P., Limbach, L.K., Dettlaff-Weglikowska, U., Krumeich, F., Roth, S., Stark, W.J., Bruinink, A., The degree and kind of agglomeration affect carbon nanotube cytotoxicity (2007) Toxicol. Lett, 168, pp. 121-131
Magrez, A., Kasa, S., Salicio, V., Pasquier, N., Seo, J.W., Celio, M., Catsicas, S., Forro, L., Cellular toxicity of carbon-based nanomaterilas (2006) Nano Lett, 6, pp. 1121-1125
Cui, D., Tian, F., Ozkan, C.S., Wang, M., Gao, H., Effect of single wall carbon nanotubes on human HEK293 cells (2005) Toxicol. Lett, 155, pp. 73-85
Pulskamp, K., Diabate, S., Krug, H.F., Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants (2007) Toxicol. Lett, 168, pp. 58-74
Garibaldi, S., Brunelli, C., Bavastrello, V., Ghigliotti, G., Nicolini, C., Carbon nanotube biocompatibility with cardiac muscle cells (2006) Nanotechnology, 17, pp. 391-397
Hurt, R. H., Monthioux, M., Kane, A., Toxicology of carbon nanomaterials: Status, trends, and perspectives on the special issue (2006) Carbon, 44, pp. 1028-1033
Smart, S. K., Cassady, A. I., Lu, G. Q., Martin, D. J., The biocompatibility of carbon nanotubes (2006) Carbon, 44, pp. 1034-1047
Manna, S. K., Sarkar, S., Barr, J., Wisw, K., Barrera, E. V., Jejelowo, O., Rice-Ficht, A. C., Ramesh, J. T., Single-walled carbon nanotubes induces oxidative stress and activates nuclear transcription factor-kB in human keratinocytes (2005) Nano Lett, 5, pp. 1676-1684
Singh, N. P., McCoy, M. T., Tice, R., Schneider, E. L., A simple technique for quantitation of low level of DNA damage in individual cells (1988) Exp. Cell. Res, 175, pp. 184-187
Zhang, H. X., Du, G. H., Zhang, J. T., Assay of mitochondrial functions by resazurin in vitro (2004) Acta Pharmacol. Sin, 25, pp. 385-389
Worle-Knirsch, J. M., Pulskamp, K., Krug, H. F., Oops they did it again! Carbon nanotubes hoax scientists in viability assays (2006) Nano Lett, 6, pp. 1261-1268
Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes
The single-wall carbon nanotubes (SWCNTs) are one of the new materials of emerging technologies. They are becoming increasingly studied for the possible applications in electronics, optics and biology. In particular, very promising fields of application are the development of optical biosensors and the intracellular drug delivery. Nevertheless, there is a paucity of information on their toxicological properties and on potential human health risk. In the present study the SWCNTs were investigated for the possible induction of toxicity in human blood cells. Cell growth, viability, apoptosis and metabolic activity were evaluated in proliferating human peripheral blood lymphocytes. In un-stimulated human leukocytes primary DNA damage was also evaluated. SWCNTs concentrations ranging from 1 to 50 μg/ml were tested, and treatment duration varied from 6 to 72 h, in accordance with the biological target investigated. A statistically significant decrease in cell growth was found in cells treated with the highest concentrations (25 and 50 μg/ml). Such decrease was not associated to cell death or apoptosis, but it was demonstrated to be related to a decrease in metabolic activity, as assessed by resazurin assay. Moreover, treatments of 6 h with SWCNTs concentrations of 1, 5 and 10 μg/ml failed to induce primary DNA damage on the entire human leukocytes population. © 2008 by MDPI.
The single-wall carbon nanotubes (SWCNTs) are one of the new materials of emerging technologies. They are becoming increasingly studied for the possible applications in electronics, optics and biology. In particular, very promising fields of application are the development of optical biosensors and the intracellular drug delivery. Nevertheless, there is a paucity of information on their toxicological properties and on potential human health risk. In the present study the SWCNTs were investigated for the possible induction of toxicity in human blood cells. Cell growth, viability, apoptosis and metabolic activity were evaluated in proliferating human peripheral blood lymphocytes. In un-stimulated human leukocytes primary DNA damage was also evaluated. SWCNTs concentrations ranging from 1 to 50 μg/ml were tested, and treatment duration varied from 6 to 72 h, in accordance with the biological target investigated. A statistically significant decrease in cell growth was found in cells treated with the highest concentrations (25 and 50 μg/ml). Such decrease was not associated to cell death or apoptosis, but it was demonstrated to be related to a decrease in metabolic activity, as assessed by resazurin assay. Moreover, treatments of 6 h with SWCNTs concentrations of 1, 5 and 10 μg/ml failed to induce primary DNA damage on the entire human leukocytes population. © 2008 by MDPI.
Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes
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Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes
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Impact Factor: 3.65
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (454 views)
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (578 views)
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Impact Factor: 3.972
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Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (1043 views)
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Impact Factor: 3.447
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Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (727 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
* The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime? (526 views)
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Impact Factor: 3.675
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
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Impact Factor: 4.907
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Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L
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Impact Factor: 3.274
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De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
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Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
Impact Factor: 2.983
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (448 views)
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Impact Factor: 1.862
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D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
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Impact Factor: 4.819
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
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Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
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Impact Factor: 2.768
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
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Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (381 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
* Enforcing the positive charge of N-termini enhances membrane interaction and antitumor activity of bovine seminal ribonuclease (478 views)
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Impact Factor: 3.99
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Adinolfi M, Capasso D, Di Gaetano S, Iadonisi A, Leone L, Pastore A
* A straightforward synthetic access to symmetrical glycosyl disulfides and biological evaluation thereof (352 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2011 Sep 21; 9(18): 6278-6283.
Impact Factor: 3.696
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (561 views)
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Impact Factor: 3.151
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Storto G, Di Giorgio E, De Renzo A, Pizzuti LM, Cerciello G, Nardelli A, Capacchione D, Castaldi E, Ortosecco G, Pace L
* Assessment of metabolic activity by PET-CT with F-18-FDG in patients with T-cell lymphoma (516 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2010 Oct; 151(2): 195-197.
Impact Factor: 4.942
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (509 views)
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Impact Factor: 5.707
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Merlino A, Russo Krauss I, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F
* Toward an Antitumor Form of Bovine Pancreatic Ribonuclease: The Crystal Structure of Three Noncovalent Dimeric Mutants (399 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1029-1037.
Impact Factor: 2.605
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (805 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (351 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
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Storto G, Di Giorgio E, Pellegrino T, Erra P, Nardelli A, Perna F, Castaldi E, Ortosecco G, Speranza A, De Renzo A, Salvatore M, Rotoli B, Pace L
* Assessment of Metabolic Activity by PET-CT with F-18-FDG in patients with T-cell Lymphoma (277 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
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Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F
* The buried diversity of bovine seminal ribonuclease: Shape and cytotoxicity of the swapped non-covalent form of the enzyme (406 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2008 Feb 15; 376(2): 427-437.
Impact Factor: 4.146
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarf MR
* Cytotoxicity Investigation On Cultured Human Blood Cells Treated With Single-Wall Carbon Nanoyubes (222 views)
Sensors, 2008; 8: 488-499.
Impact Factor: 2.245
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Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
* Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (473 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
Impact Factor: 1.801
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Naddeo M, Vitagliano L, Russo A, Gotte G, D'Alessio G, Sorrentino S
* Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor (362 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 May 9; 579(12): 2663-2668.
Impact Factor: 3.415
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Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (524 views)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
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Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (638 views)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
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Sica F, Di Fiore A, Merlino A, Mazzarella L
* Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (443 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Sep 27; 279(35): 36753-36760.
Impact Factor: 6.355
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (393 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (436 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (471 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (638 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
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Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, DeGraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB
Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin (472 views)
Nitric Oxide Biology And Chemistry (ISSN: 1089-8603), 1997 Feb; 1(1): 88-94.
Impact Factor: 2.151
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (685 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (661 views)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (517 views)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (477 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
Impact Factor: 1.342
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In Vitro and in Vivo Analyses of the Effects of Source, Length, and Charge on the Cytotoxicity and Immunocompatibility of Cellulose Nanocrystals (1 views)
Acs Biomater Sci Eng (ISSN: 2373-9878electronic), 2021 Apr 12; 7 (4 ): 1450-1461.
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Moreira M, Ruggiero A, Esposito L, Choi HG, Kim HJ, Berisio R
* Structural features of HtpGMtb and HtpG-ESAT6Mtb vaccine antigens against tuberculosis: Molecular determinants of antigenic synergy and cytotoxicity modulation (122 views) (PDF 7 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2020 May 4; 158: 305-317.
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Fusco S, Capasso D, Centore R, Di Gaetano S, Parisi E
* A new biologically active molecular scaffold: crystal structure of 7-(3-hydroxyphenyl)-4-methyl-2H-[1, 2, 4]triazolo[3, 2-c][1, 2, 4]triazole and selective antiproliferative activity of three isomeric triazolo-triazoles (104 views)
Acta Crystallogr C Struct Chem (ISSN: 2053-2296linking), 2019 Oct 1; 75(Pt10): 1398-1404.
Impact Factor: 0.93
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Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (284 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (197 views)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (361 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Bonaccorso C, Grasso G, Musso N, Barresi V, Condorelli DF, La Mendola D, Rizzarelli E
* Water soluble glucose derivative of thiocarbohydrazone acts as ionophore with cytotoxic effects on tumor cells (302 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 1873-3344electronic), 2018; 182: 92-102.
Impact Factor: 3.317
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Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (462 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
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Villari V, Tosto R, Di Natale G, Sinopoli A, Tomasello M, Lazzaro S, Micali N, Pappalardo G
* A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity (427 views)
Chemistryselect (ISSN: 2365-6549), 2017 Oct; 2(28): 9122-9129.
Impact Factor: 1.505
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Sartorio C, Figà V, Salice P, Gragnato D, Cataldo S, Scopelliti M, Improta R, Menna E, Pignataro B
* Thiophene pyrenyl derivatives for the supramolecular processability of single-walled carbon nanotubes in thin film heterojunction (206 views)
Synthetic Metals, 2017 Jul; 229: 7-15.
Impact Factor: 2.435
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Magri A, La Mendola D, Nicoletti VG, Pappalardo G, Rizzarelli E
* New Insight in Copper-Ion Binding to Human Islet Amyloid: The Contribution of Metal-Complex Speciation To Reveal the Polypeptide Toxicity (396 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Sep 5; 22(37): 13287-13300.
Impact Factor: 5.317
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Sinopoli A, Giuffrida A, Tomasello MF, Giuffrida ML, Leone M, Attanasio F, Caraci F, De Bona P, Naletova I, Saviano M, Copani A, Pappalardo G, Rizzarelli E
* Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-beta Oligomer Formation and Cytotoxicity (453 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2016 Aug 17; 17(16): 1541-1549.
Impact Factor: 2.847
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Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF
* ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (719 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 156: 145-152.
Impact Factor: 3.348
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Giaquinto M, Micco A, Aliberti A, Ricciardi A, Ruvo M, Cutolo A, Cusano A
* Microgel photonics and lab on fiber technology for advanced label-free fiber optic nanoprobes (209 views)
Proc Spie Int Soc Opt Eng (ISSN: 0277-786x9781510602199), 2016; 9916: N/D-N/D.
Impact Factor: 0.958
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Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
* Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity (461 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015 Jan; 142: 39-46.
Impact Factor: 3.205
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (408 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (456 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2015; 26(8): 1533-1541.
Impact Factor: 4.5
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Salice P, Sartorio C, Burlini A, Improta R, Pignataro B, Menna E
* On the trade-off between processability and opto-electronic properties of single wall carbon nanotube derivatives in thin film heterojunctions (250 views)
J Mater Chem C (ISSN: 2050-7526), 2015; 3(2): 303-312.
Impact Factor: 5.066
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (443 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (454 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (578 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (1043 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
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Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (727 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
* The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime? (526 views)
Front Endocrinol (ISSN: 1664-2392, 1664-2392linking, 1664-2392print), 2014; 5(DEC): 216-216.
Impact Factor: 3.675
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (444 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
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Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L
* Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: A novel and potential approach to cancer therapy (440 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2013 Sep; 125: 16-25.
Impact Factor: 3.274
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De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (608 views)
Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
Impact Factor: 2.983
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (448 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204.
Impact Factor: 1.862
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D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
* The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin (395 views)
European Journal Of Cancer (ISSN: 0959-8049), 2013 Mar; 49(5): 1142-1151.
Impact Factor: 4.819
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (493 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (410 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (475 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (381 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
* Enforcing the positive charge of N-termini enhances membrane interaction and antitumor activity of bovine seminal ribonuclease (478 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Dec; 1808(12): 3007-3015.
Impact Factor: 3.99
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Adinolfi M, Capasso D, Di Gaetano S, Iadonisi A, Leone L, Pastore A
* A straightforward synthetic access to symmetrical glycosyl disulfides and biological evaluation thereof (352 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2011 Sep 21; 9(18): 6278-6283.
Impact Factor: 3.696
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (561 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Storto G, Di Giorgio E, De Renzo A, Pizzuti LM, Cerciello G, Nardelli A, Capacchione D, Castaldi E, Ortosecco G, Pace L
* Assessment of metabolic activity by PET-CT with F-18-FDG in patients with T-cell lymphoma (516 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2010 Oct; 151(2): 195-197.
Impact Factor: 4.942
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (509 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
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Merlino A, Russo Krauss I, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F
* Toward an Antitumor Form of Bovine Pancreatic Ribonuclease: The Crystal Structure of Three Noncovalent Dimeric Mutants (399 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1029-1037.
Impact Factor: 2.605
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (805 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (351 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
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Storto G, Di Giorgio E, Pellegrino T, Erra P, Nardelli A, Perna F, Castaldi E, Ortosecco G, Speranza A, De Renzo A, Salvatore M, Rotoli B, Pace L
* Assessment of Metabolic Activity by PET-CT with F-18-FDG in patients with T-cell Lymphoma (277 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
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Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F
* The buried diversity of bovine seminal ribonuclease: Shape and cytotoxicity of the swapped non-covalent form of the enzyme (406 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2008 Feb 15; 376(2): 427-437.
Impact Factor: 4.146
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarf MR
* Cytotoxicity Investigation On Cultured Human Blood Cells Treated With Single-Wall Carbon Nanoyubes (222 views)
Sensors, 2008; 8: 488-499.
Impact Factor: 2.245
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Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
* Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (473 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
Impact Factor: 1.801
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Naddeo M, Vitagliano L, Russo A, Gotte G, D'Alessio G, Sorrentino S
* Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor (362 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 May 9; 579(12): 2663-2668.
Impact Factor: 3.415
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Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (524 views)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
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Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (638 views)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
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Sica F, Di Fiore A, Merlino A, Mazzarella L
* Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (443 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Sep 27; 279(35): 36753-36760.
Impact Factor: 6.355
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (393 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (436 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (471 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (638 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
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Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, DeGraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB
Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin (472 views)
Nitric Oxide Biology And Chemistry (ISSN: 1089-8603), 1997 Feb; 1(1): 88-94.
Impact Factor: 2.151
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (685 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (661 views)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (517 views)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (477 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
Impact Factor: 1.342
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62 Records (57 excluding Abstracts).
Total impact factor: 229.697 (215.36 excluding Abstracts).
Total 5 year impact factor: 226.456 (212.312 excluding Abstracts).
Total impact factor: 229.697 (215.36 excluding Abstracts).
Total 5 year impact factor: 226.456 (212.312 excluding Abstracts).
321 views. Last view on Saturday 14 January 2023, 17:44:54
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