γ-Glutamyl transpeptidase architecture: Effect of extra sequence deletion on autoprocessing, structure and stability of the protein from Bacillus licheniformis (318 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014; 1844(12): 2290-2297.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.882, 5-year impact factor: 4.969
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84908179204&partnerID=40&md5=0b536630c53571cd16425213e9ad8267
Keywords: Deletion Mutants, Ntn Hydrolase, Protein Stability, Site-Directed Mutagenesis, γ-Glutamyl Transpeptidase, Gamma Glutamyltransferase, Guanidine, Animal Cell, Article, Bacillus Licheniformis, Catalysis, Circular Dichroism, Controlled Study, Denaturation, Enzyme Activation, Fluorescence Spectroscopy, Gene Deletion, Nonhuman, Polyacrylamide Gel Electrophoresis, Protein Processing, Protein Structure, Sequence Alignment, Sequence Homology, Temperature,
Affiliations:
*** IBB - CNR ***
Department of Applied Chemistry, National Chiayi University, 300 Syuefu RoadChiayi City, Taiwan
Department of Chemical Sciences, University of Naples Federico IINapoli, Italy
Istituto di Biostrutture e Bioimmagini, CNRNapoli, Italy
References:
Castellano, I., Merlino, A., γ-Glutamyltranspeptidases: Sequence, structure, biochemical properties, and biotechnological applications (2012) Cell. Mol. Life Sci., 69, pp. 3381-339
Keillor, J.W., Menard, A., Castonguay, R., γ-Glutamyl transpeptidase substrate specificity and catalytic mechanism (2004) J. Phys. Org. Chem., 17, pp. 529-536
Keillor, J.W., Castonguay, R., Lherbet, C., Pre-steady-state kinetics studies of rat kidney γ-glutamyl transpeptidase confirm its ping-pong mechanism (2005) Methods Enzymol., 401, pp. 449-467
Taniguchi, N., Ikeda, Y., γ-Glutamyl transpeptidase: Catalytic mechanism and gene expression (1998) Adv. Enzymol. Relat. Areas Mol. Biol., 72, pp. 239-278
Meister, A., Tate, S.S., Griffith, O.W., γ-Glutamyl transpeptidase from kidney (1981) Methods Enzymol., 77, pp. 237-253
Emdin, M., Passino, C., Pompella, A., γ-Glutamyltransferase as a cardiovascular risk factor (2006) Eur. Heart J., 27, pp. 2145-2146
Lee, D.H., Jacobs, D.R., Jr., Gross, M., γ-Glutamyltransferase is a predictor of incident diabetes and hypertension: The coronary artery risk development in young adults (CARDIA) study (2003) Clin. Chem., 49, pp. 1358-1366
Lee, D.H., Ha, M.H., Kim, J.H., γ-Glutamyltransferase and diabetes - A 4 year follow-up study (2003) Diabetologia, 46, pp. 359-364
Hanigan, M.H., γ-Glutamyl transpeptidase, a glutathionase: Its expression and function in carcinogenesis (1998) Chem. Biol. Interact., 111-112, pp. 333-342
Corti, A., Franzini, M., Paolicchi, A., γ-Glutamyltransferase of cancer cells at the crossroads of tumor progression, drug resistance and drug targeting (2010) Anticancer Res., 30, pp. 1169-1181
Wickham, S., Regan, N., West, M.B., Thai, J., Cook, P.F., Terzyan, S.S., Li, P.K., Hanigan, M.H., Inhibition of human γ-glutamyl transpeptidase: Development of more potent, physiologically relevant, uncompetitive inhibitors (2013) Biochem. J., 450, pp. 547-557
King, J.B., West, M.B., Cook, P.F., Hanigan, M.H., A novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidase (2009) J. Biol. Chem., 284, pp. 9059-9065
Hanigan, M.H., Gallagher, B.C., Taylor, P.T., Jr., Large, M.K., Inhibition of γ-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity (1994) Cancer Res., 54, pp. 5925-5929
Tuzova, M., Jean, J.-C., Hughey, R.P., Scism Brown, L.A., Cruikshank, W., Hiratake, J., Joyce-Brady, M., Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma Front. Pharmacol.
Ferretti, M., Destro, T., Tosatto, S.C., γ-Glutamyl transferase in the cell wall participates in extracellular glutathione salvage from the root apoplast (2009) New Phytol., 181, pp. 115-126
Castellano, I., Di Salle, A., Merlino, A., Gene cloning and protein expression of γ-glutamyltranspeptidases from Thermus thermophilus and Deinococcus radiodurans: Comparison of molecular and structural properties with mesophilic counterparts (2011) Extremophiles, 15, pp. 259-270
Suzuki, H., Yamada, C., Kato, K., (2007) Amino Acids, 32, pp. 333-340
Suzuki, H., Miwa, C., Ishihara, S., A single amino acid substitution converts γ-glutamyltranspeptidase to a class IV cephalosporin acylase (glutaryl-7-aminocephalosporanic acid acylase) (2004) Appl. Environ. Microbiol., 70, pp. 6324-6328
Minami, H., Suzuki, H., Kumagai, H., A mutant Bacillus subtilis γ-glutamyl transpeptidase specialized in hydrolysis activity (2003) FEMS Microbiol. Lett., 224 (2), pp. 126-130
Suzuki, H., Izuka, S., Miyakawa, N., Enzymatic production of theanine, an 'umami' component of tea, from glutamine and ethylamine with bacterial γ-glutamyltranspeptidase (2002) Enzyme Microb. Technol., 31, pp. 884-889
Zhang, H., Zhan, Y., Chang, J., Liu, J., Xu, L., Wang, Z., Liu, Q., Liao, Q., Enzymatic synthesis β-N-(γ-l(+)-glutamyl)phenylhydrazine with Escherichia coli γ-glutamyltranspeptidase (2012) Biotechnol. Lett., 34, pp. 1931-1935
Okada, T., Suzuki, H., Wada, K., Crystal structures of γ-glutamyltranspeptidase from Escherichia coli, a key enzyme in glutathione metabolism, and its reaction intermediate (2006) Proc. Natl. Acad. Sci. U. S. A., 103, pp. 6471-6476
Boanca, G., Sand, A., Barycki, J.J., Uncoupling the enzymatic and autoprocessing activities of Helicobacter pylori γ-glutamyltranspeptidase (2006) J. Biol. Chem., 281, pp. 19029-19037
Boanca, Sand, A., Okada, T., Autoprocessing of Helicobacter pylori γ-glutamyltranspeptidase leads to the formation of a threonine-threonine catalytic dyad (2007) J. Biol. Chem., 282, pp. 534-541
Pica, A., Russo Krauss, I., Castellano, I., Exploring the unfolding mechanism of γ-glutamyltranspeptidases: The case of the thermophilic enzyme from Geobacillus thermodenitrificans (2012) Biochim. Biophys. Acta-Proteins Proteomics, 1824, pp. 571-577
West, M.B., Hanigan, M.H., γ-Glutamyl transpeptidase is a heavily N-glycosylated heterodimer in HepG2 cells (2010) Arch. Biochem. Biophys., 504 (2), pp. 177-181
West, M.B., Wickham, S., Quinalty, L.M., Pavlovicz, R.E., Li, C., Hanigan, M.H., Autocatalytic cleavage of human γ-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95 (2011) J. Biol. Chem., 286, pp. 28876-28888
West, M.B., Chen, Y., Wickham, S., Novel insights into eukaryotic γ-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme (2013) J. Biol. Chem., 288, pp. 31902-31913
Wada, K., Irie, M., Suzuki, H., Crystal structure of the halotolerant γ-glutamyltranspeptidase from Bacillus subtilis in complex with glutamate reveals a unique architecture of the solvent-exposed catalytic pocket (2010) FEBS J., 277, pp. 1000-1009
Lin, L.-L., Chou, P.R., Hua, Y.W., Overexpression, one-step purification, and biochemical characterization of a recombinant γ-glutamyltranspeptidase from Bacillus licheniformis (2006) Appl. Microbiol. Biotechnol., 73, pp. 103-112
Chi, M.-C., Chen, Y.-Y., Lo, H.-F., Lin, L.-L., Experimental evidence for the involvement of amino acid residue Glu398 in the autocatalytic processing of Bacillus licheniformis γ-glutamyltranspeptidase (2012) Febs Open Biol., 2, pp. 299-304
Tate, S.S., Meister, A., Interaction of γ-glutamyl transpeptidase with amino acids, dipeptides, and derivatives and analogs of glutathione (1974) J. Biol. Chem., 249, pp. 7593-7602
Böhm, G., Muhr, R., Jaenicke, R., Quantitative analysis of protein far UV circular dichroism spectra by neural networks (1992) Protein Eng., 5, pp. 191-195
Scholtz, J.M., Grimsley, G.R., Pace, C.N., Solvent denaturation of proteins and interpretations of the m value (2009) Methods Enzymol., 466, pp. 549-565
Lin, L.-L., Lin, M.-C., Chen, Y.-Y., Merlino, A., Low resolution X-ray structure of γ-glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion (2014) Biochim. Biophys. Acta Proteins Proteomics, 1844, pp. 1523-1529
Guex, N., Peitsch, M.C., Schwede, T., Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective (2009) Electrophoresis, 30, pp. 162-S173
Delano, W.L., (2010) New York: Schrödinger, LLC, 2010. The PyMOL Molecular Graphics System, Version 1.3r1
Kishore, D., Kundu, S., Kayastha, A.M., Thermal, chemical and pH induced denaturation of a multimeric β-galactosidase reveals multiple unfolding pathways (2012) PLoS One, 7 (11), p. 50380
Merlino, A., Russo Krauss, I., Castellano, I., De Vendittis, E., Rossi, B., Conte, M., Vergara, A., Sica, F., Structure and flexibility in cold-adapted iron superoxide dismutases: The case of the enzyme isolated from Pseudoalteromonas haloplanktis (2010) J. Struct. Biol., 172, pp. 343-352
Granata, V., Del Vecchio, P., Barone, G., Shehi, E., Fusi, P., Tortora, P., Graziano, G., Guanidine-induced unfolding of the Sso7d protein from the hyperthermophilic archaeon Sulfolobus solfataricus (2004) Int. J. Biol. Macromol., 34, pp. 195-201
Keillor, J. W., Menard, A., Castonguay, R., -Glutamyl transpeptidase substrate specificity and catalytic mechanism (2004) J. Phys. Org. Chem., 17, pp. 529-536
Keillor, J. W., Castonguay, R., Lherbet, C., Pre-steady-state kinetics studies of rat kidney -glutamyl transpeptidase confirm its ping-pong mechanism (2005) Methods Enzymol., 401, pp. 449-467
Lee, D. H., Jacobs, D. R., Jr., Gross, M., -Glutamyltransferase is a predictor of incident diabetes and hypertension: The coronary artery risk development in young adults (CARDIA) study (2003) Clin. Chem., 49, pp. 1358-1366
Lee, D. H., Ha, M. H., Kim, J. H., -Glutamyltransferase and diabetes - A 4 year follow-up study (2003) Diabetologia, 46, pp. 359-364
Hanigan, M. H., -Glutamyl transpeptidase, a glutathionase: Its expression and function in carcinogenesis (1998) Chem. Biol. Interact., 111-112, pp. 333-342
King, J. B., West, M. B., Cook, P. F., Hanigan, M. H., A novel, species-specific class of uncompetitive inhibitors of -glutamyl transpeptidase (2009) J. Biol. Chem., 284, pp. 9059-9065
Hanigan, M. H., Gallagher, B. C., Taylor, P. T., Jr., Large, M. K., Inhibition of -glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity (1994) Cancer Res., 54, pp. 5925-5929
West, M. B., Hanigan, M. H., -Glutamyl transpeptidase is a heavily N-glycosylated heterodimer in HepG2 cells (2010) Arch. Biochem. Biophys., 504 (2), pp. 177-181
West, M. B., Wickham, S., Quinalty, L. M., Pavlovicz, R. E., Li, C., Hanigan, M. H., Autocatalytic cleavage of human -glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95 (2011) J. Biol. Chem., 286, pp. 28876-28888
West, M. B., Chen, Y., Wickham, S., Novel insights into eukaryotic -glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme (2013) J. Biol. Chem., 288, pp. 31902-31913
Lin, L. -L., Chou, P. R., Hua, Y. W., Overexpression, one-step purification, and biochemical characterization of a recombinant -glutamyltranspeptidase from Bacillus licheniformis (2006) Appl. Microbiol. Biotechnol., 73, pp. 103-112
Chi, M. -C., Chen, Y. -Y., Lo, H. -F., Lin, L. -L., Experimental evidence for the involvement of amino acid residue Glu398 in the autocatalytic processing of Bacillus licheniformis -glutamyltranspeptidase (2012) Febs Open Biol., 2, pp. 299-304
Tate, S. S., Meister, A., Interaction of -glutamyl transpeptidase with amino acids, dipeptides, and derivatives and analogs of glutathione (1974) J. Biol. Chem., 249, pp. 7593-7602
B hm, G., Muhr, R., Jaenicke, R., Quantitative analysis of protein far UV circular dichroism spectra by neural networks (1992) Protein Eng., 5, pp. 191-195
Scholtz, J. M., Grimsley, G. R., Pace, C. N., Solvent denaturation of proteins and interpretations of the m value (2009) Methods Enzymol., 466, pp. 549-565
Lin, L. -L., Lin, M. -C., Chen, Y. -Y., Merlino, A., Low resolution X-ray structure of -glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion (2014) Biochim. Biophys. Acta Proteins Proteomics, 1844, pp. 1523-1529
Delano, W. L., (2010) New York: Schr dinger, LLC, 2010. The PyMOL Molecular Graphics System, Version 1. 3r1
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014; 1844(12): 2290-2297.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.882, 5-year impact factor: 4.969
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84908179204&partnerID=40&md5=0b536630c53571cd16425213e9ad8267
Keywords: Deletion Mutants, Ntn Hydrolase, Protein Stability, Site-Directed Mutagenesis, γ-Glutamyl Transpeptidase, Gamma Glutamyltransferase, Guanidine, Animal Cell, Article, Bacillus Licheniformis, Catalysis, Circular Dichroism, Controlled Study, Denaturation, Enzyme Activation, Fluorescence Spectroscopy, Gene Deletion, Nonhuman, Polyacrylamide Gel Electrophoresis, Protein Processing, Protein Structure, Sequence Alignment, Sequence Homology, Temperature,
Affiliations:
*** IBB - CNR ***
Department of Applied Chemistry, National Chiayi University, 300 Syuefu RoadChiayi City, Taiwan
Department of Chemical Sciences, University of Naples Federico IINapoli, Italy
Istituto di Biostrutture e Bioimmagini, CNRNapoli, Italy
References:
Castellano, I., Merlino, A., γ-Glutamyltranspeptidases: Sequence, structure, biochemical properties, and biotechnological applications (2012) Cell. Mol. Life Sci., 69, pp. 3381-339
Keillor, J.W., Menard, A., Castonguay, R., γ-Glutamyl transpeptidase substrate specificity and catalytic mechanism (2004) J. Phys. Org. Chem., 17, pp. 529-536
Keillor, J.W., Castonguay, R., Lherbet, C., Pre-steady-state kinetics studies of rat kidney γ-glutamyl transpeptidase confirm its ping-pong mechanism (2005) Methods Enzymol., 401, pp. 449-467
Taniguchi, N., Ikeda, Y., γ-Glutamyl transpeptidase: Catalytic mechanism and gene expression (1998) Adv. Enzymol. Relat. Areas Mol. Biol., 72, pp. 239-278
Meister, A., Tate, S.S., Griffith, O.W., γ-Glutamyl transpeptidase from kidney (1981) Methods Enzymol., 77, pp. 237-253
Emdin, M., Passino, C., Pompella, A., γ-Glutamyltransferase as a cardiovascular risk factor (2006) Eur. Heart J., 27, pp. 2145-2146
Lee, D.H., Jacobs, D.R., Jr., Gross, M., γ-Glutamyltransferase is a predictor of incident diabetes and hypertension: The coronary artery risk development in young adults (CARDIA) study (2003) Clin. Chem., 49, pp. 1358-1366
Lee, D.H., Ha, M.H., Kim, J.H., γ-Glutamyltransferase and diabetes - A 4 year follow-up study (2003) Diabetologia, 46, pp. 359-364
Hanigan, M.H., γ-Glutamyl transpeptidase, a glutathionase: Its expression and function in carcinogenesis (1998) Chem. Biol. Interact., 111-112, pp. 333-342
Corti, A., Franzini, M., Paolicchi, A., γ-Glutamyltransferase of cancer cells at the crossroads of tumor progression, drug resistance and drug targeting (2010) Anticancer Res., 30, pp. 1169-1181
Wickham, S., Regan, N., West, M.B., Thai, J., Cook, P.F., Terzyan, S.S., Li, P.K., Hanigan, M.H., Inhibition of human γ-glutamyl transpeptidase: Development of more potent, physiologically relevant, uncompetitive inhibitors (2013) Biochem. J., 450, pp. 547-557
King, J.B., West, M.B., Cook, P.F., Hanigan, M.H., A novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidase (2009) J. Biol. Chem., 284, pp. 9059-9065
Hanigan, M.H., Gallagher, B.C., Taylor, P.T., Jr., Large, M.K., Inhibition of γ-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity (1994) Cancer Res., 54, pp. 5925-5929
Tuzova, M., Jean, J.-C., Hughey, R.P., Scism Brown, L.A., Cruikshank, W., Hiratake, J., Joyce-Brady, M., Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma Front. Pharmacol.
Ferretti, M., Destro, T., Tosatto, S.C., γ-Glutamyl transferase in the cell wall participates in extracellular glutathione salvage from the root apoplast (2009) New Phytol., 181, pp. 115-126
Castellano, I., Di Salle, A., Merlino, A., Gene cloning and protein expression of γ-glutamyltranspeptidases from Thermus thermophilus and Deinococcus radiodurans: Comparison of molecular and structural properties with mesophilic counterparts (2011) Extremophiles, 15, pp. 259-270
Suzuki, H., Yamada, C., Kato, K., (2007) Amino Acids, 32, pp. 333-340
Suzuki, H., Miwa, C., Ishihara, S., A single amino acid substitution converts γ-glutamyltranspeptidase to a class IV cephalosporin acylase (glutaryl-7-aminocephalosporanic acid acylase) (2004) Appl. Environ. Microbiol., 70, pp. 6324-6328
Minami, H., Suzuki, H., Kumagai, H., A mutant Bacillus subtilis γ-glutamyl transpeptidase specialized in hydrolysis activity (2003) FEMS Microbiol. Lett., 224 (2), pp. 126-130
Suzuki, H., Izuka, S., Miyakawa, N., Enzymatic production of theanine, an 'umami' component of tea, from glutamine and ethylamine with bacterial γ-glutamyltranspeptidase (2002) Enzyme Microb. Technol., 31, pp. 884-889
Zhang, H., Zhan, Y., Chang, J., Liu, J., Xu, L., Wang, Z., Liu, Q., Liao, Q., Enzymatic synthesis β-N-(γ-l(+)-glutamyl)phenylhydrazine with Escherichia coli γ-glutamyltranspeptidase (2012) Biotechnol. Lett., 34, pp. 1931-1935
Okada, T., Suzuki, H., Wada, K., Crystal structures of γ-glutamyltranspeptidase from Escherichia coli, a key enzyme in glutathione metabolism, and its reaction intermediate (2006) Proc. Natl. Acad. Sci. U. S. A., 103, pp. 6471-6476
Boanca, G., Sand, A., Barycki, J.J., Uncoupling the enzymatic and autoprocessing activities of Helicobacter pylori γ-glutamyltranspeptidase (2006) J. Biol. Chem., 281, pp. 19029-19037
Boanca, Sand, A., Okada, T., Autoprocessing of Helicobacter pylori γ-glutamyltranspeptidase leads to the formation of a threonine-threonine catalytic dyad (2007) J. Biol. Chem., 282, pp. 534-541
Pica, A., Russo Krauss, I., Castellano, I., Exploring the unfolding mechanism of γ-glutamyltranspeptidases: The case of the thermophilic enzyme from Geobacillus thermodenitrificans (2012) Biochim. Biophys. Acta-Proteins Proteomics, 1824, pp. 571-577
West, M.B., Hanigan, M.H., γ-Glutamyl transpeptidase is a heavily N-glycosylated heterodimer in HepG2 cells (2010) Arch. Biochem. Biophys., 504 (2), pp. 177-181
West, M.B., Wickham, S., Quinalty, L.M., Pavlovicz, R.E., Li, C., Hanigan, M.H., Autocatalytic cleavage of human γ-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95 (2011) J. Biol. Chem., 286, pp. 28876-28888
West, M.B., Chen, Y., Wickham, S., Novel insights into eukaryotic γ-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme (2013) J. Biol. Chem., 288, pp. 31902-31913
Wada, K., Irie, M., Suzuki, H., Crystal structure of the halotolerant γ-glutamyltranspeptidase from Bacillus subtilis in complex with glutamate reveals a unique architecture of the solvent-exposed catalytic pocket (2010) FEBS J., 277, pp. 1000-1009
Lin, L.-L., Chou, P.R., Hua, Y.W., Overexpression, one-step purification, and biochemical characterization of a recombinant γ-glutamyltranspeptidase from Bacillus licheniformis (2006) Appl. Microbiol. Biotechnol., 73, pp. 103-112
Chi, M.-C., Chen, Y.-Y., Lo, H.-F., Lin, L.-L., Experimental evidence for the involvement of amino acid residue Glu398 in the autocatalytic processing of Bacillus licheniformis γ-glutamyltranspeptidase (2012) Febs Open Biol., 2, pp. 299-304
Tate, S.S., Meister, A., Interaction of γ-glutamyl transpeptidase with amino acids, dipeptides, and derivatives and analogs of glutathione (1974) J. Biol. Chem., 249, pp. 7593-7602
Böhm, G., Muhr, R., Jaenicke, R., Quantitative analysis of protein far UV circular dichroism spectra by neural networks (1992) Protein Eng., 5, pp. 191-195
Scholtz, J.M., Grimsley, G.R., Pace, C.N., Solvent denaturation of proteins and interpretations of the m value (2009) Methods Enzymol., 466, pp. 549-565
Lin, L.-L., Lin, M.-C., Chen, Y.-Y., Merlino, A., Low resolution X-ray structure of γ-glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion (2014) Biochim. Biophys. Acta Proteins Proteomics, 1844, pp. 1523-1529
Guex, N., Peitsch, M.C., Schwede, T., Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective (2009) Electrophoresis, 30, pp. 162-S173
Delano, W.L., (2010) New York: Schrödinger, LLC, 2010. The PyMOL Molecular Graphics System, Version 1.3r1
Kishore, D., Kundu, S., Kayastha, A.M., Thermal, chemical and pH induced denaturation of a multimeric β-galactosidase reveals multiple unfolding pathways (2012) PLoS One, 7 (11), p. 50380
Merlino, A., Russo Krauss, I., Castellano, I., De Vendittis, E., Rossi, B., Conte, M., Vergara, A., Sica, F., Structure and flexibility in cold-adapted iron superoxide dismutases: The case of the enzyme isolated from Pseudoalteromonas haloplanktis (2010) J. Struct. Biol., 172, pp. 343-352
Granata, V., Del Vecchio, P., Barone, G., Shehi, E., Fusi, P., Tortora, P., Graziano, G., Guanidine-induced unfolding of the Sso7d protein from the hyperthermophilic archaeon Sulfolobus solfataricus (2004) Int. J. Biol. Macromol., 34, pp. 195-201
Keillor, J. W., Menard, A., Castonguay, R., -Glutamyl transpeptidase substrate specificity and catalytic mechanism (2004) J. Phys. Org. Chem., 17, pp. 529-536
Keillor, J. W., Castonguay, R., Lherbet, C., Pre-steady-state kinetics studies of rat kidney -glutamyl transpeptidase confirm its ping-pong mechanism (2005) Methods Enzymol., 401, pp. 449-467
Lee, D. H., Jacobs, D. R., Jr., Gross, M., -Glutamyltransferase is a predictor of incident diabetes and hypertension: The coronary artery risk development in young adults (CARDIA) study (2003) Clin. Chem., 49, pp. 1358-1366
Lee, D. H., Ha, M. H., Kim, J. H., -Glutamyltransferase and diabetes - A 4 year follow-up study (2003) Diabetologia, 46, pp. 359-364
Hanigan, M. H., -Glutamyl transpeptidase, a glutathionase: Its expression and function in carcinogenesis (1998) Chem. Biol. Interact., 111-112, pp. 333-342
King, J. B., West, M. B., Cook, P. F., Hanigan, M. H., A novel, species-specific class of uncompetitive inhibitors of -glutamyl transpeptidase (2009) J. Biol. Chem., 284, pp. 9059-9065
Hanigan, M. H., Gallagher, B. C., Taylor, P. T., Jr., Large, M. K., Inhibition of -glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity (1994) Cancer Res., 54, pp. 5925-5929
West, M. B., Hanigan, M. H., -Glutamyl transpeptidase is a heavily N-glycosylated heterodimer in HepG2 cells (2010) Arch. Biochem. Biophys., 504 (2), pp. 177-181
West, M. B., Wickham, S., Quinalty, L. M., Pavlovicz, R. E., Li, C., Hanigan, M. H., Autocatalytic cleavage of human -glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95 (2011) J. Biol. Chem., 286, pp. 28876-28888
West, M. B., Chen, Y., Wickham, S., Novel insights into eukaryotic -glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme (2013) J. Biol. Chem., 288, pp. 31902-31913
Lin, L. -L., Chou, P. R., Hua, Y. W., Overexpression, one-step purification, and biochemical characterization of a recombinant -glutamyltranspeptidase from Bacillus licheniformis (2006) Appl. Microbiol. Biotechnol., 73, pp. 103-112
Chi, M. -C., Chen, Y. -Y., Lo, H. -F., Lin, L. -L., Experimental evidence for the involvement of amino acid residue Glu398 in the autocatalytic processing of Bacillus licheniformis -glutamyltranspeptidase (2012) Febs Open Biol., 2, pp. 299-304
Tate, S. S., Meister, A., Interaction of -glutamyl transpeptidase with amino acids, dipeptides, and derivatives and analogs of glutathione (1974) J. Biol. Chem., 249, pp. 7593-7602
B hm, G., Muhr, R., Jaenicke, R., Quantitative analysis of protein far UV circular dichroism spectra by neural networks (1992) Protein Eng., 5, pp. 191-195
Scholtz, J. M., Grimsley, G. R., Pace, C. N., Solvent denaturation of proteins and interpretations of the m value (2009) Methods Enzymol., 466, pp. 549-565
Lin, L. -L., Lin, M. -C., Chen, Y. -Y., Merlino, A., Low resolution X-ray structure of -glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion (2014) Biochim. Biophys. Acta Proteins Proteomics, 1844, pp. 1523-1529
Delano, W. L., (2010) New York: Schr dinger, LLC, 2010. The PyMOL Molecular Graphics System, Version 1. 3r1
γ-Glutamyl transpeptidase architecture: Effect of extra sequence deletion on autoprocessing, structure and stability of the protein from Bacillus licheniformis
γ-Glutamyl transpeptidases (γ-GTs, EC 2.3.2.2) are a class of ubiquitous enzymes which initiate the cleavage of extracellular glutathione (γ-Glu-Cys-Gly, GSH) into its constituent glutamate, cysteine, and glycine and catalyze the transfer of its γ-glutamyl group to water (hydrolysis), amino acids or small peptides (transpeptidation). These proteins utilize a conserved Thr residue to process their chains into a large and a small subunit that then form the catalytically competent enzyme. Multiple sequence alignments have shown that some bacterial γ-GTs, including that from Bacillus licheniformis (BlGT), possess an extra sequence at the C-terminal tail of the large subunit, whose role is unknown. Here, autoprocessing, structure, catalytic activity and stability against both temperature and the chemical denaturant guanidinium hydrochloride of six BlGT extra-sequence deletion mutants have been characterized by SDS-PAGE, circular dichroism, intrinsic fluorescence and homology modeling. Data suggest that the extra sequence has a crucial role in enzyme activation and structural stability. Our results assist in the development of a structure-based interpretation of the autoprocessing reaction of γ-GTs and are helpful to unveil the molecular bases of their structural stability.
γ-Glutamyl transpeptidases (γ-GTs, EC 2.3.2.2) are a class of ubiquitous enzymes which initiate the cleavage of extracellular glutathione (γ-Glu-Cys-Gly, GSH) into its constituent glutamate, cysteine, and glycine and catalyze the transfer of its γ-glutamyl group to water (hydrolysis), amino acids or small peptides (transpeptidation). These proteins utilize a conserved Thr residue to process their chains into a large and a small subunit that then form the catalytically competent enzyme. Multiple sequence alignments have shown that some bacterial γ-GTs, including that from Bacillus licheniformis (BlGT), possess an extra sequence at the C-terminal tail of the large subunit, whose role is unknown. Here, autoprocessing, structure, catalytic activity and stability against both temperature and the chemical denaturant guanidinium hydrochloride of six BlGT extra-sequence deletion mutants have been characterized by SDS-PAGE, circular dichroism, intrinsic fluorescence and homology modeling. Data suggest that the extra sequence has a crucial role in enzyme activation and structural stability. Our results assist in the development of a structure-based interpretation of the autoprocessing reaction of γ-GTs and are helpful to unveil the molecular bases of their structural stability.
γ-Glutamyl transpeptidase architecture: Effect of extra sequence deletion on autoprocessing, structure and stability of the protein from Bacillus licheniformis
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γ-Glutamyl transpeptidase architecture: Effect of extra sequence deletion on autoprocessing, structure and stability of the protein from Bacillus licheniformis
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Prion (ISSN: 1933-6896), 2010 Jul; 4(3): N/D-N/D.
Impact Factor: 2.468
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Torres Martin De Rosales R, Faiella M, Farquhar E, Que L, J , Andreozzi C, Pavone V, Maglio O, Nastri F, Lombardi A
* Spectroscopic and metal-binding properties of DF3: an artificial protein able to accommodate different metal ions (311 views)
J Biol Inorg Chem (ISSN: 1432-1327electronic, 0949-8257linking, 0949-8257print), 2010 Jun; 15(5): 717-728.
Impact Factor: 3.287
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Esposito C, Carullo C, Pedone E, Graziano G, Del Vecchio P, Berisio R
* Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: Implications for bacterial agglutination (494 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 0014-5793linking), 2010 Mar 19; 584(6): 1091-1096.
Impact Factor: 3.601
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Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A
* An artificial di-iron oxo-protein with phenol oxidase activity (433 views)
Nat Chem Biol (ISSN: 1552-4450), 2009 Dec; 5(12): 882-884.
Impact Factor: 16.058
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Vitagliano L, Stanzione F, De Simone A, Esposito L
* Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (690 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1161-1171.
Impact Factor: 2.605
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Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L
* The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability (436 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2009 Dec; 77(4): 1004-1008.
Impact Factor: 3.085
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Vergara A, Franzese M, Merlino A, Bonomi G, Verde C, Giordano D, Di Prisco G, Lee HC, Peisach J, Mazzarella L
* Correlation between Hemichrome Stability and the Root Effect in Tetrameric Hemoglobins (407 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2009 Sep 5; 97(3): 866-874.
Impact Factor: 4.39
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Ruggiero A, Lanzotti MA, Ruocco MR, Grimaldi P, Marasco D, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of two dimeric hyperthermostable thioredoxins isolated from Sulfolobus solfataricus (337 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2009 Jun; 65: 604-607.
Impact Factor: 0.551
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Daniele A, Scala I, Cardillo G, Pennino C, Ungaro C, Sibilio M, Parenti G, Esposito L, Zagari A, Andria G, Salvatore F
* Functional and structural characterization of novel mutations and genotype-phenotype correlation in 51 phenylalanine hydroxylase deficient families from Southern Italy (423 views)
Febs Journal (ISSN: 1742-464x), 2009 Apr; 276(7): 2048-2059.
Impact Factor: 3.042
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Berisio R, De Simone A, Ruggiero A, Improta R, Vitagliano L
* Role of side chains in collagen triple helix stabilization and partner recognition (676 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 131-140.
Impact Factor: 1.807
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Ruggiero A, Masullo M, Ruocco MR, Grimaldi P, Lanzotti MA, Arcari P, Zagari A, Vitagliano L
* Structure and stability of a thioredoxin reductase from Sulfolobus solfataricus: A thermostable protein with two functions (347 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2009 Mar; 1794(3): 554-562.
Impact Factor: 2.48
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Limauro D, Saviano M, Galdi I, Rossi M, Bartolucci S, Pedone E
* Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites (236 views)
Protein Engineering Design & Selection (ISSN: 1741-0126), 2009 Jan; 22(1): 19-26.
Impact Factor: 2.596
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Ronga L, Palladino P, Ragone R, Benedetti E, Rossi F
* A thermodynamic approach to the conformational preferences of the 180-195 segment derived from the human prion protein α2-helix (287 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009; 15(1): 30-35.
Impact Factor: 1.807
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Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (638 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
Impact Factor: 2.648
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (562 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Doti N, Marasco D, Sabatella M, Monti SM, Dathan N, Viparelli F, Cassese A, Miele C, Pedone C, Ruvo M
* An analysis of deletion mutants of the PLD1 D4 domain defines short regions within the PLD1 interacting with PED/PEA15: implications for the development of peptides-specific antagonist (423 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Improta R, Berisio R, Vitagliano L
* Contribution of dipole-dipole interactions to the stability of the collagen triple helix (405 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2008 May; 17(5): 955-961.
Impact Factor: 3.115
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Stability Against Temperature Of Sulfolobus Solfataricus Elongation Factor 1 Alpha, A Multi-Domain Protein (380 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Apr; 1784(4): 573-581.
Impact Factor: 2.233
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De Simone A, Pedone C, Vitagliano L
* Structure, dynamics, and stability of assemblies of the human prion fragment SNQNNF (503 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Feb 15; 366(3): 800-806.
Impact Factor: 2.648
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Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (420 views)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
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Staiano M, Saviano M, Herman P, Grycznyski Z, Fini C, Varriale A, Parracino A, Kold AB, Rossi M, D'Auria S
* Time-resolved fluorescence spectroscopy and molecular dynamics simulations point out the effects of pressure on the stability and dynamics of the porcine odorant-binding protein (683 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 89(4): 284-291.
Impact Factor: 2.823
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Manetto GD, Grasso DM, Milardi D, Pappalardo M, Guzzi R, Sportelli L, Verbeet MP, Canters GW, La Rosa C
* The role played by the α-helix in the unfolding pathway and stability of azurin: Switching between hierarchic and nonhierarchic folding (356 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 Nov 5; 8(16): 1941-1949.
Impact Factor: 3.446
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Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
* The Prokaryotic Cys2his2 Zinc Finger Domain Adopts A Novel Fold As Revealed By The Solution Structure Of Agrobacterium Tumefaciens Ros Dna Binding Domain (480 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007 Oct 30; 104(44): 17341-17346.
Impact Factor: 9.598
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (493 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
Impact Factor: 4.472
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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De Simone A, Berisio R, Zagari A, Vitagliano L
* Limited Tendency Of Alpha-Helical Residues To Form Disulfide Bridges: A Structural Explanation (486 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 740-747.
Impact Factor: 1.801
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Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (493 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (768 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
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Granata V, Palladino P, Tizzano B, Negro A, Berisio R, Zagari A
* The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH (402 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Jun 15; 82(3): 234-240.
Impact Factor: 2.48
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Merlino A, Esposito L, Vitagliano L
* Polyglutamine Repeats And Beta-Helix Structure: Molecular Dynamics Study (534 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jun 1; 63(4): 918-927.
Impact Factor: 3.73
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Musumeci D, Valente M, Capasso D, Palumbo R, Gorlach M, Schmidtke M, Zell R, Roviello GN, Sapio R, Pedone C, Bucci EM
* A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis (423 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
Impact Factor: 1.801
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Mazzarella L, Bonomi G, Lubrano MC, Merlino A, Riccio A, Vergara A, Vitagliano L, Verde C, Di Prisco G
* Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (507 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 1; 62(2): 316-321.
Impact Factor: 3.73
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Chemical Denaturation Of The Elongation Factor 1 Alpha Isolated From The Hyperthermophilic Archaeon Sulfolobus Solfataricus (358 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Jan 24; 45(3): 719-726.
Impact Factor: 3.633
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Herga S, Brutus A, Vitale RM, Miche H, Perrier J, Puigserver A, Scaloni A, Giardina T
* Site-directed mutagenesis and molecular modelling studies show the role of Asp82 and cysteines in rat acylase 1, a member of the M20 family (338 views)
Biochem Biophys Res Commun (ISSN: 0006-291xprint, 0006-291xlinking), 2005 May 6; 330(2): 540-546.
Impact Factor: 3
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Lahr SJ, Engel DE, Stayrook SE, Maglio O, North B, Geremia S, Lombardi A, Degrado WF
* Analysis and design of turns in α-helical hairpins (472 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2005; 346(5): 1441-1454.
Impact Factor: 5.229
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (423 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (742 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004 May 25; 43(20): 6043-6058.
Impact Factor: 4.008
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Berisio R, Granata V, Vitagliano L, Zagari A
* Characterization of Collagen-Like Heterotrimers: Implications for Triple-Helix Stability (604 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 682-688.
Impact Factor: 2.863
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Aloj L, Zannetti A, Caracó C, Del Vecchio S, Salvatore M
* Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (556 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004; 31(4): 521-527.
Impact Factor: 3.935
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Ohlenschlager O, Wohnert J, Bucci E, Seitz S, Hafner S, Ramachandran R, Zell R, Gorlach M
* The Structure of the Stemloop D Subdomain of Coxsackievirus B3 Cloverleaf RNA and Its Interaction with the Proteinase 3C (626 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2004; 12(2): 237-248.
Impact Factor: 5.185
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Milardi D, Grasso DM, Verbeet MP, Canters GW, La Rosa C
* Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: Synergism among multiple depletions (330 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2003 Jun 1; 414(1): 121-127.
Impact Factor: 2.338
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Main ERG, Xiong Y, Cocco MJ, D'Andrea LD, Regan L
* Design of stable α-helical arrays from an idealized TPR motif (941 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2003; 11(5): 497-508.
Impact Factor: 5.993
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Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD
* Differences In The Central Nervous System Distribution And Pharmacology Of The Mouse 5-Hydroxytryptamine-6 Receptor Compared With Rat And Human Receptors Investigated By Radioligand Binding, Site-Directed Mutagenesis, And Molecular Modeling (272 views)
Molecular Pharmacology, 2003; 64: 1295-1308.
Impact Factor: 4.12
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Esposito G, Vitagliano L, Santamaria R, Viola A, Zagari A, Salvatore F
* Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance (311 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2002 Nov 6; 531(2): 152-156.
Impact Factor: 3.912
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Berisio R, Vitagliano L, Mazzarella L, Zagari A
* Crystal structure of the collagen triple helix model [(Pro-Pro-Gly)10]3 (660 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2002 Feb; 11(2): 262-270.
Impact Factor: 3.546
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (435 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Vitagliano L, Berisio R, Mastrangelo A, Mazzarella L, Zagari A
* Preferred proline puckerings in cis and trans peptide groups: Implications for collagen stability (753 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2001 Dec; 10(12): 2627-2632.
Impact Factor: 3.472
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Vitagliano L, Berisio R, Mazzarella L, Zagari A
* Structural bases of collagen stabilization induced by proline hydroxylation (724 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2001 Apr 15; 58(5): 459-464.
Impact Factor: 1.845
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Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (418 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
Impact Factor: 2.425
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PEARL L, DEMASI D, HEMMINGS A, SICA F, MAZZARELLA L, RAIA C, DAURIA S, ROSSI M
CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF AN NAD+-DEPENDENT ALCOHOL-DEHYDROGENASE FROM THE EXTREME THERMOPHILIC ARCHAEBACTERIUM SULFOLOBUS-SOLFATARICUS (445 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1993 Feb 5; 229(3): 782-784.
Impact Factor: 5.673
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* Members of the GADD45 Protein Family Show Distinct Propensities to form Toxic Amyloid-Like Aggregates in Physiological Conditions (19 views)
Int J Mol Sci (ISSN: 1422-0067linking), 2021 Oct 2; 22 (19 ): N/D-N/D.
Impact Factor:
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Cozzolino S, Balasco N, Vigorita M, Ruggiero A, Smaldone G, Del Vecchio P, Vitagliano L, Graziano G
* Guanidinium binding to proteins: The intriguing effects on the D1 and D2 domains of Thermotoga maritima Arginine Binding Protein and a comprehensive analysis of the Protein Data Bank (66 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2020 Nov 15; 163: 375-385.
Impact Factor: 5.162
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Smaldone G, Ruggiero A, Balasco N, Vitagliano L
* Development of a Protein Scaffold for Arginine Sensing Generated through the Dissection of the Arginine-Binding Protein from Thermotoga maritima (72 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Oct 12; 21(20): N/D-N/D.
Impact Factor: 4.556
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Smaldone G, Balasco N, Pirone L, Caruso D, Di Gaetano S, Pedone EM, Vitagliano L
* Molecular basis of the scalp-ear-nipple syndrome unraveled by the characterization of disease-causing KCTD1 mutants (153 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2019 Jul 19; 9(1): 10519-10519.
Impact Factor: 5.078
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Ruggiero A, Smaldone G, Esposito L, Balasco N, Vitagliano L
* Loop size optimization induces a strong thermal stabilization of the thioredoxin fold (193 views)
Febs J (ISSN: 1742-464xlinking), 2019 May; 286(9): 1752-1764.
Impact Factor: 3.129
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Balasco N, Smaldone G, Vigorita M, Del Vecchio P, Graziano G, Ruggiero A, Vitagliano L
* The characterization of Thermotoga maritima Arginine Binding Protein variants demonstrates that minimal local strains have an important impact on protein stability (108 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2019 Apr 29; 9(1): 6617-6617.
Impact Factor: 5.078
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Mercurio FA, Di Natale C, Pirone L, Marasco D, Calce E, Vincenzi M, Pedone EM, De Luca S, Leone M
* Design and analysis of EphA2-SAM peptide ligands: A multi-disciplinary screening approach (229 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2019 Mar; 84: 434-443.
Impact Factor: 3.929
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Balasco N, Smaldone G, Ruggiero A, De Simone A, Vitagliano L
* Local structural motifs in proteins: Detection and characterization of fragments inserted in helices (240 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2018 Oct 15; 118(PtB): 1924-1930.
Impact Factor: 3.909
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Ruggiero A, Garcia-ortega L, Ragucci S, Russo R, Landi N, Berisio R, Di Maro A
* Structural and enzymatic properties of Ageritin, a novel metal-dependent ribotoxin-like protein with antitumor activity (348 views)
Bba-Gen Subjects (ISSN: 1872-8006electronic, 0304-4165linking, 0304-4165print), 2018 Sep 18; 1862(12): 2888-2894.
Impact Factor: 3.679
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Buonanno M, Di Fiore A, Langella E, D’ambrosio K, Supuran CT, Monti SM, De Simone G
* The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior (304 views)
Int J Mol Sc (ISSN: 1661-6596, 1422-0067, 1422-0067electronic), 2018 May; 19(6): 19-24.
Impact Factor: 3.687
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Ruggiero A, Squeglia F, Romano M, Vitagliano L, De Simone A, Berisio R
* Structure and dynamics of the multi-domain resuscitation promoting factor RpfB from Mycobacterium tuberculosis (359 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2017 May; 35(6): 1322-1330.
Impact Factor: 3.107
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Balasco N, Esposito L, Thind AS, Guarracino MR, Vitagliano L
* Dissection of Factors Affecting the Variability of the Peptide Bond Geometry and Planarity (344 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141), 2017; 2017: 2617629-2617629.
Impact Factor: 2.583
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Pirone L, Smaldone G, Esposito C, Balasco N, Petoukhov MV, Spilotros A, Svergun DI, Di Gaetano S, Vitagliano L, Pedone E
* Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners (323 views) (PDF 192 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2016 Sep 24; 131: 106-114.
Impact Factor: 3.112
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Scognamiglio PL, Di Natale C, Leone M, Cascella R, Cecchi C, Lirussi L, Antoniali G, Riccardi D, Morelli G, Tell G, Chiti F, Marasco D
* Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia (396 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2016 Sep 13; 7(37): 59129-59143.
Impact Factor: 5.168
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Smaldone G, Vigorita M, Ruggiero A, Balasco N, Dattelbaum JD, D'Auria S, Del Vecchio P, Graziano G, Vitagliano L
* Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima Arginine Binding Protein (314 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Jul; 1864(7): 814-824.
Impact Factor: 4.932
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Ruvo M, Doti N, Lorenzo V, Vitagliano L, Mascanzoni F
* The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability (280 views)
Mol Biotechnol (ISSN: 1073-6085, 1559-0305electronic, 1073-6085linking), 2016 May; 58(5): 328-339.
Impact Factor: 1.634
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Del Giudice R, Arciello A, Itri F, Merlino A, Monti M, Buonanno M, Penco A, Canetti D, Petruk G, Monti SM, Relini A, Pucci P, Piccoli R, Monti DM
* Protein conformational perturbations in hereditary amyloidosis: Differential impact of single point mutations in ApoAI amyloidogenic variants (412 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2016; 1860(2): 434-444.
Impact Factor: 5.476
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Pica A, Chi M-C, Chen Y-Y, D'Ischia M, Lin L-L, Merlino A
* The maturation mechanism of γ-glutamyl transpeptidases: Insights from the crystal structure of a precursor mimic of the enzyme from Bacillus licheniformis and from site-directed mutagenesis studies (417 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2016; 1864(2): 195-203.
Impact Factor: 5.476
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (497 views)
Biochemistry (ISSN: 0006-2960, 1520-4995), 2015 Sep 15; 54(36): 5646-5656.
Impact Factor: 2.876
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De Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazza D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L
* Cullin3 - BTB interface: A novel target for stapled peptides (569 views) (PDF 44 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Apr 7; 10(4): e0121149-e0121149.
Impact Factor: 3.057
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Berisio R, Squeglia F, Ruggiero A, Petraccone L, Stellato MI, Del Vecchio P
* Differential thermodynamic behaviours of the extra-cellular regions of two Ser/Thr PrkC kinases revealed by calorimetric studies (438 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Feb 8; 1854(5): 402-409.
Impact Factor: 5.158
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Balasco N, Barone D, Vitagliano L
* Structural conversion of the transformer protein RfaH: new insights derived from protein structure prediction and molecular dynamics simulations (471 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2015 Jan 12; 33(10): 2173-2179.
Impact Factor: 2.3
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Bisconte MG, Caldora M, Musollino G, Cardiero G, Flagiello A, La Porta G, Lagona L, Prezioso R, Qualtieri G, Gaudiano C, Medulla E, Merlino A, Pucci P, Lacerra G
* α-thalassemia associated with Hb instability: A tale of two features. The case of Hb Rogliano or α1 Cod 108(G15)Thr→Asn and Hb Policoro or α2 Cod 124(H7)Ser→Pro (421 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015; 10(3): N/D-N/D.
Impact Factor: 3.057
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Pica A, Graziano G
* On the effect of sodium chloride and sodium sulfate on cold denaturation (307 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015; 10(7): N/D-N/D.
Impact Factor: 3.057
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Benetti F, Biarnés X, Attanasio F, Giachin G, Rizzarelli E, Legname G
* Structural determinants in prion protein folding and stability (910 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 0022-2836linking), 2014 Nov 11; 426(22): 3796-3810.
Impact Factor: 4.333
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Graziano G, Merlino A
* Molecular bases of protein halotolerance (408 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Apr; 1844(4): 850-858.
Impact Factor: 4.882
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Andreotti G, Citro V, Correra A, Cubellis MV
* A thermodynamic assay to test pharmacological chaperones for Fabry disease (396 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1840(3): 1214-1224.
Impact Factor: 4.882
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Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F
* Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability (642 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1844(3): 632-640.
Impact Factor: 4.882
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Lin L-L, Chen Y-Y, Chi M-C, Merlino A
* Low resolution X-ray structure of γ-glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion (696 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014; 1844(9): 1523-1529.
Impact Factor: 4.882
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Petruk AA, Varriale S, Coscia MR, Mazzarella L, Merlino A, Oreste U
* The Structure Of The Cd3 Zeta Zeta Transmembrane Dimer In Popc And Raft-Like Lipid Bilayer: A Molecular Dynamics Study (498 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002e, 0005-2736print), 2013 Nov; 1828(11): 2637-2645.
Impact Factor: 3.498
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Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (500 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
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Sandomenico A, Severino V, Chambery A, Focà A, Focà G, Farina C, Ruvo M
* A Comparative Structural and Bioanalytical Study of IVIG Clinical Lots (474 views)
Mol Biotechnol (ISSN: 1073-6085, 1559-0305electronic, 1073-6085linking), 2013 Jul; 54(3): 983-995.
Impact Factor: 2.275
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Balasco N, Esposito L, De Simone A, Vitagliano L
* Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (353 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013 Jul; 22(7): 1016-1023.
Impact Factor: 2.861
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De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (700 views)
Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
Impact Factor: 2.983
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Avitabile C, Capparelli R, Rigano MM, Fulgione A, Barone A, Pedone C, Romanelli A
* Antimicrobial peptides from plants: Stabilization of the γ core of a tomato defensin by intramolecular disulfide bond (865 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 240-245.
Impact Factor: 1.862
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Marasco D, Ruggiero A, Vascotto C, Poletto M, Scognamiglio PL, Tell G, Vitagliano L
* Role of mutual interactions in the chemical and thermal stability of nucleophosmin NPM1 domains (326 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x), 2013 Jan 11; 430(2): 523-528.
Impact Factor: 2.281
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Buanne P, Renzone G, Monteleone F, Vitale M, Monti SM, Sandomenico A, Garbi C, Montanaro D, Accardo M, Troncone G, Zatovicova M, Csaderova L, Supuran CT, Pastorekova S, Scaloni A, De Simone G, Zambrano N
* Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells (394 views)
J Proteome Res (ISSN: 1535-3893), 2013 Jan; 12(1): 282-292.
Impact Factor: 5.001
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Balasco N, Esposito L, De Simone A, Vitagliano L
* FOR the RECORD: Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (620 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013; 22(7): 1016-1023.
Impact Factor: 2.861
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Lin LL, Merlino A
* Heterogeneous nucleation helps the search for initial crystallization conditions of γ-glutamyl transpeptidase from Bacillus licheniformis (280 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2013; 69(6): 669-672.
Impact Factor: 0.568
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (755 views)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
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Esposito L, Balasco N, De Simone A, Berisio R, Vitagliano L
* Interplay between peptide bond geometrical parameters in nonglobular structural contexts (464 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: N/D-N/D.
Impact Factor: 2.13
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (496 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2013; 452(3): 545-557.
Impact Factor: 4.779
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Pirone L, Esposito C, Correale S, Graziano G, Di Gaetano S, Vitagliano L, Pedone E
* Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization (486 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: 162674-162674.
Impact Factor: 1.579
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Russo Krauss I, Merlino A, Randazzo A, Novellino E, Mazzarella L, Sica F
* High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity (561 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2012 Sep; 40(16): 8119-8128.
Impact Factor: 8.278
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Ruggiero A, Smaldone G, Squeglia F, Berisio R
* Enhanced crystallizability by protein engineering approaches: A general overview (2087 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Jul; 19(7): 732-742.
Impact Factor: 1.994
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La Mendola D, Magrì A, Santoro AM, Nicoletti VG, Rizzarelli E
* Copper(II) interaction with peptide fragments of histidine-proline-rich glycoprotein: Speciation, stability and binding details (409 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 59-69.
Impact Factor: 3.197
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Di Maro A, Berisio R, Ruggiero A, Tamburino R, Severino V, Zacchia E, Parente A
* Structural and enzymatic properties of an in vivo proteolytic form of PD-S2, type 1 ribosome-inactivating protein from seeds of Phytolacca dioica (357 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 May 11; 421(3): 514-520.
Impact Factor: 2.406
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Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
* Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (451 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 7; 7(5): e35774-e35774.
Impact Factor: 3.73
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Merlino A, Picone D, Ercole C, Balsamo A, Sica F
* Chain termini cross-talk in the swapping process of bovine pancreatic ribonuclease (284 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1108-1118.
Impact Factor: 3.142
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Ascione G, de Pascale D, De Santi C, Pedone C, Dathan NA, Monti SM
* Native expression and purification of hormone-sensitive lipase from Psychrobacter sp. TA144 enhances protein stability and activity (510 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2012 Apr 13; 420(3): 542-546.
Impact Factor: 2.406
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Pica A, Russo Krauss I, Castellano I, Rossi M, La Cara F, Graziano G, Sica F, Merlino A
* Exploring The Unfolding Mechanism Of Gamma-Glutamyltranspeptidases: The Case Of The Thermophilic Enzyme From Geobacillus Thermodenitrificans (566 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2012 Apr; 1824(4): 571-577.
Impact Factor: 3.733
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Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (301 views)
J Struct Biol (ISSN: 1047-8477, 1047-8477linking), 2012 Feb; 177(2): 506-512.
Impact Factor: 3.361
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Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (595 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
Impact Factor: 5.925
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Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (710 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (532 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
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Vitagliano L, Berisio R, De Simone A
* Role of hydration in collagen recognition by bacterial adhesins (666 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2011 May 4; 100(9): 2253-2261.
Impact Factor: 3.653
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Merlino A, Howes BD, Prisco G, Verde C, Smulevich G, Mazzarella L, Vergara A
* Occurrence and formation of endogenous histidine hexa-coordination in cold-adapted hemoglobins (410 views)
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 May; 63(5): 295-303.
Impact Factor: 3.514
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Evidences for supramolecular organization of nucleopeptides: Synthesis, spectroscopic and biological studies of a novel dithymine l-serine tetrapeptide (578 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 Apr; 7(4): 1073-1080.
Impact Factor: 3.534
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Russo Krauss I, Merlino A, Giancola C, Randazzo A, Mazzarella L, Sica F
* Thrombin-aptamer recognition: a revealed ambiguity (578 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2011; 39(17): 7858-7867.
Impact Factor: 8.026
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Vergara A, Vitagliano L, Merlino A, Sica F, Marino K, Verde C, di Prisco G, Mazzarella L
* An Order-Disorder Transition Plays a Role in Switching Off the Root Effect in Fish Hemoglobins (363 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Oct 15; 285(42): 32568-32575.
Impact Factor: 5.328
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Benetti F, Pastorino L, Attanasio F, Rizzarelli E, Legname G
* Insights into Prion Protein Stability (267 views)
Prion (ISSN: 1933-6896), 2010 Jul; 4(3): N/D-N/D.
Impact Factor: 2.468
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Torres Martin De Rosales R, Faiella M, Farquhar E, Que L, J , Andreozzi C, Pavone V, Maglio O, Nastri F, Lombardi A
* Spectroscopic and metal-binding properties of DF3: an artificial protein able to accommodate different metal ions (311 views)
J Biol Inorg Chem (ISSN: 1432-1327electronic, 0949-8257linking, 0949-8257print), 2010 Jun; 15(5): 717-728.
Impact Factor: 3.287
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Esposito C, Carullo C, Pedone E, Graziano G, Del Vecchio P, Berisio R
* Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: Implications for bacterial agglutination (494 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 0014-5793linking), 2010 Mar 19; 584(6): 1091-1096.
Impact Factor: 3.601
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Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A
* An artificial di-iron oxo-protein with phenol oxidase activity (433 views)
Nat Chem Biol (ISSN: 1552-4450), 2009 Dec; 5(12): 882-884.
Impact Factor: 16.058
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Vitagliano L, Stanzione F, De Simone A, Esposito L
* Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (690 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1161-1171.
Impact Factor: 2.605
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Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L
* The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability (436 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2009 Dec; 77(4): 1004-1008.
Impact Factor: 3.085
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Vergara A, Franzese M, Merlino A, Bonomi G, Verde C, Giordano D, Di Prisco G, Lee HC, Peisach J, Mazzarella L
* Correlation between Hemichrome Stability and the Root Effect in Tetrameric Hemoglobins (407 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2009 Sep 5; 97(3): 866-874.
Impact Factor: 4.39
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Ruggiero A, Lanzotti MA, Ruocco MR, Grimaldi P, Marasco D, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of two dimeric hyperthermostable thioredoxins isolated from Sulfolobus solfataricus (337 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2009 Jun; 65: 604-607.
Impact Factor: 0.551
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Daniele A, Scala I, Cardillo G, Pennino C, Ungaro C, Sibilio M, Parenti G, Esposito L, Zagari A, Andria G, Salvatore F
* Functional and structural characterization of novel mutations and genotype-phenotype correlation in 51 phenylalanine hydroxylase deficient families from Southern Italy (423 views)
Febs Journal (ISSN: 1742-464x), 2009 Apr; 276(7): 2048-2059.
Impact Factor: 3.042
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Berisio R, De Simone A, Ruggiero A, Improta R, Vitagliano L
* Role of side chains in collagen triple helix stabilization and partner recognition (676 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 131-140.
Impact Factor: 1.807
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Ruggiero A, Masullo M, Ruocco MR, Grimaldi P, Lanzotti MA, Arcari P, Zagari A, Vitagliano L
* Structure and stability of a thioredoxin reductase from Sulfolobus solfataricus: A thermostable protein with two functions (347 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2009 Mar; 1794(3): 554-562.
Impact Factor: 2.48
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Limauro D, Saviano M, Galdi I, Rossi M, Bartolucci S, Pedone E
* Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites (236 views)
Protein Engineering Design & Selection (ISSN: 1741-0126), 2009 Jan; 22(1): 19-26.
Impact Factor: 2.596
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Ronga L, Palladino P, Ragone R, Benedetti E, Rossi F
* A thermodynamic approach to the conformational preferences of the 180-195 segment derived from the human prion protein α2-helix (287 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009; 15(1): 30-35.
Impact Factor: 1.807
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Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (638 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
Impact Factor: 2.648
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (562 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Doti N, Marasco D, Sabatella M, Monti SM, Dathan N, Viparelli F, Cassese A, Miele C, Pedone C, Ruvo M
* An analysis of deletion mutants of the PLD1 D4 domain defines short regions within the PLD1 interacting with PED/PEA15: implications for the development of peptides-specific antagonist (423 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Improta R, Berisio R, Vitagliano L
* Contribution of dipole-dipole interactions to the stability of the collagen triple helix (405 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2008 May; 17(5): 955-961.
Impact Factor: 3.115
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Stability Against Temperature Of Sulfolobus Solfataricus Elongation Factor 1 Alpha, A Multi-Domain Protein (380 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Apr; 1784(4): 573-581.
Impact Factor: 2.233
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De Simone A, Pedone C, Vitagliano L
* Structure, dynamics, and stability of assemblies of the human prion fragment SNQNNF (503 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Feb 15; 366(3): 800-806.
Impact Factor: 2.648
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Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (420 views)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
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Staiano M, Saviano M, Herman P, Grycznyski Z, Fini C, Varriale A, Parracino A, Kold AB, Rossi M, D'Auria S
* Time-resolved fluorescence spectroscopy and molecular dynamics simulations point out the effects of pressure on the stability and dynamics of the porcine odorant-binding protein (683 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 89(4): 284-291.
Impact Factor: 2.823
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Manetto GD, Grasso DM, Milardi D, Pappalardo M, Guzzi R, Sportelli L, Verbeet MP, Canters GW, La Rosa C
* The role played by the α-helix in the unfolding pathway and stability of azurin: Switching between hierarchic and nonhierarchic folding (356 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 Nov 5; 8(16): 1941-1949.
Impact Factor: 3.446
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Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
* The Prokaryotic Cys2his2 Zinc Finger Domain Adopts A Novel Fold As Revealed By The Solution Structure Of Agrobacterium Tumefaciens Ros Dna Binding Domain (480 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007 Oct 30; 104(44): 17341-17346.
Impact Factor: 9.598
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Vitagliano L, Ruggiero A, Pedone C, Berisio R
* A Molecular Dynamics Study of Pilus Subunits: Insights into Pilus Biogenesis (493 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2007 Apr 6; 367(4): 935-941.
Impact Factor: 4.472
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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De Simone A, Berisio R, Zagari A, Vitagliano L
* Limited Tendency Of Alpha-Helical Residues To Form Disulfide Bridges: A Structural Explanation (486 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 740-747.
Impact Factor: 1.801
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Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (493 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (768 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
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Granata V, Palladino P, Tizzano B, Negro A, Berisio R, Zagari A
* The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH (402 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Jun 15; 82(3): 234-240.
Impact Factor: 2.48
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Merlino A, Esposito L, Vitagliano L
* Polyglutamine Repeats And Beta-Helix Structure: Molecular Dynamics Study (534 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jun 1; 63(4): 918-927.
Impact Factor: 3.73
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Musumeci D, Valente M, Capasso D, Palumbo R, Gorlach M, Schmidtke M, Zell R, Roviello GN, Sapio R, Pedone C, Bucci EM
* A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis (423 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
Impact Factor: 1.801
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Mazzarella L, Bonomi G, Lubrano MC, Merlino A, Riccio A, Vergara A, Vitagliano L, Verde C, Di Prisco G
* Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (507 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 1; 62(2): 316-321.
Impact Factor: 3.73
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Chemical Denaturation Of The Elongation Factor 1 Alpha Isolated From The Hyperthermophilic Archaeon Sulfolobus Solfataricus (358 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Jan 24; 45(3): 719-726.
Impact Factor: 3.633
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Herga S, Brutus A, Vitale RM, Miche H, Perrier J, Puigserver A, Scaloni A, Giardina T
* Site-directed mutagenesis and molecular modelling studies show the role of Asp82 and cysteines in rat acylase 1, a member of the M20 family (338 views)
Biochem Biophys Res Commun (ISSN: 0006-291xprint, 0006-291xlinking), 2005 May 6; 330(2): 540-546.
Impact Factor: 3
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Lahr SJ, Engel DE, Stayrook SE, Maglio O, North B, Geremia S, Lombardi A, Degrado WF
* Analysis and design of turns in α-helical hairpins (472 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2005; 346(5): 1441-1454.
Impact Factor: 5.229
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (423 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (742 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004 May 25; 43(20): 6043-6058.
Impact Factor: 4.008
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Berisio R, Granata V, Vitagliano L, Zagari A
* Characterization of Collagen-Like Heterotrimers: Implications for Triple-Helix Stability (604 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 682-688.
Impact Factor: 2.863
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Aloj L, Zannetti A, Caracó C, Del Vecchio S, Salvatore M
* Bcl-2 overexpression prevents 99mTc-MIBI uptake in breast cancer cell lines (556 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004; 31(4): 521-527.
Impact Factor: 3.935
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Ohlenschlager O, Wohnert J, Bucci E, Seitz S, Hafner S, Ramachandran R, Zell R, Gorlach M
* The Structure of the Stemloop D Subdomain of Coxsackievirus B3 Cloverleaf RNA and Its Interaction with the Proteinase 3C (626 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2004; 12(2): 237-248.
Impact Factor: 5.185
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Milardi D, Grasso DM, Verbeet MP, Canters GW, La Rosa C
* Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: Synergism among multiple depletions (330 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2003 Jun 1; 414(1): 121-127.
Impact Factor: 2.338
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Main ERG, Xiong Y, Cocco MJ, D'Andrea LD, Regan L
* Design of stable α-helical arrays from an idealized TPR motif (941 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2003; 11(5): 497-508.
Impact Factor: 5.993
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Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD
* Differences In The Central Nervous System Distribution And Pharmacology Of The Mouse 5-Hydroxytryptamine-6 Receptor Compared With Rat And Human Receptors Investigated By Radioligand Binding, Site-Directed Mutagenesis, And Molecular Modeling (272 views)
Molecular Pharmacology, 2003; 64: 1295-1308.
Impact Factor: 4.12
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Esposito G, Vitagliano L, Santamaria R, Viola A, Zagari A, Salvatore F
* Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance (311 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2002 Nov 6; 531(2): 152-156.
Impact Factor: 3.912
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Berisio R, Vitagliano L, Mazzarella L, Zagari A
* Crystal structure of the collagen triple helix model [(Pro-Pro-Gly)10]3 (660 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2002 Feb; 11(2): 262-270.
Impact Factor: 3.546
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (435 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Vitagliano L, Berisio R, Mastrangelo A, Mazzarella L, Zagari A
* Preferred proline puckerings in cis and trans peptide groups: Implications for collagen stability (753 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2001 Dec; 10(12): 2627-2632.
Impact Factor: 3.472
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Vitagliano L, Berisio R, Mazzarella L, Zagari A
* Structural bases of collagen stabilization induced by proline hydroxylation (724 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2001 Apr 15; 58(5): 459-464.
Impact Factor: 1.845
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Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (418 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
Impact Factor: 2.425
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PEARL L, DEMASI D, HEMMINGS A, SICA F, MAZZARELLA L, RAIA C, DAURIA S, ROSSI M
CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF AN NAD+-DEPENDENT ALCOHOL-DEHYDROGENASE FROM THE EXTREME THERMOPHILIC ARCHAEBACTERIUM SULFOLOBUS-SOLFATARICUS (445 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1993 Feb 5; 229(3): 782-784.
Impact Factor: 5.673
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111 Records (108 excluding Abstracts).
Total impact factor: 407.227 (399.375 excluding Abstracts).
Total 5 year impact factor: 411.558 (402.702 excluding Abstracts).
Total impact factor: 407.227 (399.375 excluding Abstracts).
Total 5 year impact factor: 411.558 (402.702 excluding Abstracts).
318 views. Last view on Friday 02 June 2023, 6:47:29
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