Quantitative thallium-201 and technetium 99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction
Quantitative thallium-201 and technetium 99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction(344 views) Cuocolo A, Acampa W, Nicolai E, Pace L, Petretta M, Salvatore M
Affiliations: Nuclear Medicine Center, National Council of Research (CNR), Pozzilli, Italy
Dept. Biomorphological Funct. Sci., Institute of Internal Medicine, Pozzilli, Italy
Cardiology and Heart Surgery, University Federico II, Napoli, INM Neuromed, Pozzilli, Italy
Ctro. per la Med. Nucleare del CNR, Università Federico II, Via Pansini, 5-80131, Napoli, Italy
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Beller, G. A., Ragosta, M., Extent of myocardial viability in regions of left ventricular dysfunction by rest-redistribution thallium-201 imaging: A powerful predictor of outcome (1998) J Nucl Cardiol, 5, pp. 445-448
Maublant, J. C., Citron, B., Lipiecki, J., Rest technetium 99m-sestamibi tomoscintigraphy in hibernating myocardium (1995) Am Heart J, 129, pp. 306-314
Kauffman, G. J., Boyne, T. S., Watson, D. D., Smith, W. H., Beller, G. A., Comparison of resting Tl-201 imaging and resting Tc-99m-sestamibi imaging for assessment of myocardial viability in patients with coronary artery disease and severe left ventricular dysfunction (1996) J Am Coll Cardiol, 27, pp. 1592-1597
Iskandrian, A. S., Hakki, S. A., Goel, I. P., Goel, I. P., Mundth, E. D., Segal, B. L., Rest and redistribution thallium-201 myocardial scintigraphy to predict improvement in left ventricular function after coronary artery bypass grafting (1983) Am J Cardiol, 51, pp. 1312-1316
Udelson, E. J., Coleman, P. S., Metheral, J., Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201 Tl and 99m Tc-sestamibi (1994) Circulation, 89, pp. 2552-2561
Sciagr, R., Santoro, G. M., Bisi, B., Pedenovi, P., Fazzini, P. F., Pupi, A., Rest-redistribution thallium-201 SPECT to detect myocardial viability (1998) J Nucl Med, 39, pp. 385-390
Volpe, M., Rao, M. A. E., Cuocolo, A., Radionuclide monitoring of cardiac adaptations to volume loading in patients with dilated cardiomyopathy and mild heart failure (1995) Circulation, 92, pp. 2511-2518
Maes, A. F., Borges, M., Flameng, W., Assessment of myocardial viability in chronic coronary artery disease using technetium-99m sestamibi SPECT. Correlation with histologic and positron emission tomographic studies and functional follow-up (1997) J Am Coll Cardiol, 29, pp. 62-68
Dakik, H. A., Howell, J. F., Lawrie, G. M., Assessment of myocardial viability with Tc-99m sestamibi tomography before coronary bypass graft surgery: Correlation with histopathology and postoperative improvement in cardiac function (1997) Circulation, 96, pp. 2892-2898
Quantitative thallium-201 and technetium 99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction
Background. This study was designed to determine the most effective quantitative threshold for thallium-201 and technetium 99m sestamibi uptake on tomographic imaging after rest injection for the detection of myocardial viability in patients with chronic myocardial infarction. Methods and Results. Thallium and sestamibi cardiac tomography at rest was performed in 43 patients with chronic myocardial infarction and impaired left ventricular (LV) function undergoing coronary revascularization. In all patients, echocardiography and radionuclide angiography were performed at baseline and repeated 12 months later to evaluate recovery of regional LV function and LV ejection fraction, respectively. Optimal threshold cutoff points to separate reversible from irreversible dysfunction were determined by receiver operating characteristic analysis. When all dysfunctional segments were considered, the best cutoff point in the identification of reversible LV dysfunction for both thallium and sestamibi activity was 67%. When only akinetic or dyskinetic segments were considered, the best cutoff point in the identification of reversible LV dysfunction was 58% for thallium and 55% for sestamibi. In these segments, the area under the receiving operating characteristic curves constructed for thallium and sestamibi activity were 0.74 ± 0.05 and 0.75 ± 0.04, respectively (P = not significant). LV ejection fraction was 33% ± 7% at baseline and increased to 37% ± 7% after revascularization (P < .0001). A significant relation between the number of akinetic or dyskinetic but viable myocardial segments and revascularization-induced changes in LV ejection fraction was observed for both thallium (r = 0.60, P < .0001) and sestamibi (r = 0.64, P < .0001) imaging. Conclusions. In patients with chronic myocardial infarction, quantitative analysis of thallium and sestamibi activity on tomographic imaging at rest predicts recovery of regional and global LV dysfunction after revascularization procedures. The most effective quantitative threshold for detecting reversible LV dysfunction is comparable for thallium and sestamibi tomographic imaging. However, the optimal cutoff point is different for both tracers when all dysfunctional segments are considered or when the analysis is focused only on segments with more severe functional impairment (ie, akinetic or dyskinetic segments).
Quantitative thallium-201 and technetium 99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction
Quantitative thallium-201 and technetium 99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(449 views) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 ViewExport to BibTeXExport to EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(694 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote