The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue
CNR Ibb | back to homepage
CNR Ibb | back to homepage

The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (569 views)

Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I

Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.

Export to BibTeX    Export to EndNote

Paper type: Journal Article, Research Support, Non-U. S. Gov'T,

Impact factor: 4.147, 5-year impact factor: 4.215

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-55249116042&partnerID=40&md5=ddb02b0b535c250876d784ea7070d35d

Keywords: Amyloid Beta Protein, Amyloid Beta Protein (1 16), Amyloid Beta-Protein (1-16), Copper, Macrogol Derivative, Peptide Fragment, Water, Article, Chemistry, Genetics, Metabolism, Point Mutation, Potentiometry, Protein Conformation, Spectroscopy, Polyethylene Glycols, Protons, Spectrum Analysis,

Affiliations:
*** IBB - CNR ***

Department of Chemical Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy
Department of Inorganic and Analytical Chemistry, University of Debrecen, 4010 Debrecen, Hungary
CNR Institute of Biostructures and Bioimaging, V.le A. Doria, 95125 Catania, Italy


References:
Anfisen, C.B., (1973) Science, 181, pp. 223-23

Ellis, R.J., Pinheiro, T.J., (2002) Nature, 416, pp. 483-484

Kelly, J.W., (1998) Curr. Opin. Struct. Biol, 8, pp. 101-106

Dobson, C.M., (1999) Trends Biochem. Sci, 24, pp. 329-332

Carrell, R.V., Lomas, D.A., (1997) Lancet, 350, pp. 134-138

Berke, S.J.S., Paulson, H.L., (2003) Curr. Opin. Genet. Dev, 13, pp. 253-261

Soto, C., (2003) Nature Rev. Neurosci, 4, pp. 49-60

Selkoe, D.J., (1999) Nature, 399, pp. 23-31

Glenner, G.G., Wong, C.W., (1984) Biochem Biophys. Res. Commun, 122, pp. 1131-1135

Masters, C.L., Simms, G., Weinman, N.A., Multhaup, G., McDonald, B.L., Beyreuther, K., (1985) Proc. Natl. Acad. Sci. U.S.A, 82, pp. 4245-4249

Kang, J., Lemaire, H.G., Unterbeck, A., Salbaum, J.M., Masters, C.L., Grzeschik, K.H., Multhaup, G., Muller-Hill, B., (1987) Nature, 325, pp. 733-736

Inoue, S., Kuroiwa, M., Kisilevski, R., (1999) Brain Res. Rev, 29, pp. 218-231

Pike, C.J., Burdick, D., Walencewicz, A.J., Glabe, C.G., Cotman, C.W., (1993) J. Neurosci, 13, pp. 1676-1687

Yankner, B.A., (1996) Neuron, 16, pp. 921-932

Walsh, D.M., Hartley, D.M., Kusumoto, Y., Fezoni, Y., Condron, M.M., Lomakin, A., Benedek, G.B., Teplow, D.B., (1999) J. Biol. Chem, 274, pp. 25945-25952

Fraser, P.E., Nguyen, J.T., Surewicz, W.K., Selkoe, D.J., Podlisny, M.B., Kirshner, D.A., (1992) Biochemistry, 31, pp. 10716-10723

Burdick, D., Soreghan, B., Kwon, M., Kosmoski, J., Knamer, M., Henshen, A., Yates, J., Glabe, C., (1992) J. Biol. Chem, 267, pp. 546-554

Yip, C.M., Darabie, A.A., McLaurin, J., (2002) J. Mol. Biol, 318, pp. 97-107

Ambroggio, E.E., Kim, D.H., Separovic, F., Barrow, C.J., Barnham, K.J., Bagatolli, L.A., Fedelio, G.D., (2005) Biophys. J, 88, pp. 2706-2713

Wisniewski, T., Frangione, B., (1992) Neurosci. Lett, 135, pp. 235-238

Vitek, M.P., Bhattacharia, K., Glendening, J.M., Stopa, E., Vlassara, H., Bucala, R., Manogue, K., Cerami, A., (1994) Proc. Natl. Acad. Sci. U.S.A, 91, pp. 4766-4770

Bush, A.I., Petringell, W.H., Multhaup, G., de Paradis, M., Vonsattel, J.P., Gusella, J.F., Beyreuther, K., Tanzi, R.E., (1994) Science, 265, pp. 1464-1467

Atwood, C.S., Moir, R.D., Huang, X., Scarpa, R.C., Bacarra, N.M., Romano, D.M., Harthorn, M.A., Bush, A.I., (1998) J. Biol. Chem, 273, pp. 12817-12826

Bush, A.I., (2003) Trends Neurosci, 26, pp. 207-214

Maynard, C.J., Bush, A.I., Masters, C.L., Cappai, R., Li, Q.-X., (2005) Int. J. Exp. Path, 86, pp. 147-159

White, A.R., Barnham, K.J., Bush, A.I., (2006) Expert Rev. Neurother, 6, pp. 711-722

Danscher, G., Jensen, K.B., Frederickson, C.J., Kemp, K., Andreasen, A., Juhl, S., Stoltenberg, M., Ravid, R., (1997) J. Neurosci. Methods, 76, pp. 53-59

Lovell, M.A., Robertson, J.D., Teesdale, W.J., Markesbery, W.R., (1998) J. Neurol. Sci, 158, pp. 47-52

Liu, G., Huang, W., Moir, R.D., Vanderburg, C.R., Lai, B., Peng, Z., Tanzi, R.E., Huang, H., (2006) J. Struct. Biol, 155, pp. 45-51

Miller, L.M., Wang, Q., Telivala, T.P., Smith, R.J., Lanzirotti, A., Miklossy, J., (2006) J. Struct. Biol, 155, pp. 30-37

Lee, J.Y., Cole, T.B., Palmiter, R.D., Suh, S.W., Koh, J.Y., (2002) Proc. Natl. Acad. Sci. U.S.A, 99, pp. 7705-7710

Sparks, D.L., Schreurs, B.G., (2003) Proc. Natl. Acad. Sci. U.S.A, 100, pp. 11065-11069

Bayer, T.A., Schafer, S., Simons, S., Kemmling, A., Kamer, T., Tepest, R., Eckert, A., Multhaup, G., (2003) Proc. Natl. Acad. Sci. U.S.A, 100, pp. 14187-14192

Phinney, A.L., Drisaldi, B., Schmidt, S.D., Lugowski, S., Coronado, V., Liang, Y., Horne, P., Westaway, D., (2003) Proc. Natl. Acad. Sci. U.S.A, 100, pp. 14193-14198

Zou, J., Kajita, K., Sugimoto, N., (2001) Angew. Chem., Int. Ed, 40, pp. 2274-2277

Cuajungco, M.P., Faget, K.Y., (2003) Brain Res. Rev, 41, pp. 44-56

Cherny, R.A., Atwood, C.S., Xilinas, M.E., Gray, D.N., Jones, W.D., McLean, C.A., Barnham, K.J., Bush, A.I., (2001) Neuron, 30, pp. 665-676

Finefrock, A.E., Bush, A.I., Doraiswamy, P.M., (2003) J. Am. Geriatr. Soc, 51, pp. 1143-1148

Raman, B., Ban, T., Yamaguchi, K., Sakai, M., Kawai, T., Naiki, H., Goto, Y., (2005) J. Biol. Chem, 280, pp. 16157-16162

Gaggelli, E., Kozlowski, H., Valensin, D., Valensin, G., (2006) Chem. Rev, 106, pp. 1995-2044

Smith, D.P., Smith, D.G., Curtain, C.C., Boas, J.F., Pilbrow, J.R., Ciccotosto, G.D., Lau, T.-L., Barnham, K.J., (2006) J. Biol. Chem, 281, pp. 15145-15154

Karr, J.W., Akintoye, H., Kaupp, L.J., Szalai, V.A., (2005) Biochemistry, 44, pp. 5478-5487

Kozin, S.A., Zirah, S., Rebuffat, S., Hui Bon Hoa, G., Debey, P., (2001) Biochem. Biophys. Res. Commun, 285, pp. 959-964

Zirah, S., Kozin, S.A., Mazur, A.K., Blond, A., Cheminant, M., Ségalas-Milazzo, I., Debey, P., Rebuffat, S., (2006) J. Biol. Chem, 281, pp. 2151-2161

Curtain, C.C., Ali, F., Volitakis, I., Cherny, R.A., Norton, R.S., Beyreuther, K., Barrow, C.J., Barnham, K.J., (2001) J. Biol. Chem, 276, pp. 20466-20473

Huang, X., Atwood, C.S., Hartshorn, M.A., Vonsattel, J.P., Tanzi, R.E., Bush, A.I., (1997) J. Biol. Chem, 272, pp. 26464-26470

Atwood, C.S., Scarpa, R.C., Huang, X., Moir, R.D., Jones, W.D., Fairlie, D.P., Tanzi, R.E., Bush, A.I., (2000) J. Neurochem, 75, pp. 1219-1233

Miura, T., Suzuki, K., Kohata, N., Takeuchi, H., (2000) Biochemistry, 39, pp. 7024-7031

Ma, Q.-F., Hu, J., Wu, W.-H., Liu, H.-D., Fu, Y., Wu, Y.-W., Lei, P., Li, Y.-M., (2006) Biopolymers, 83, pp. 20-31

Syme, C.D., Nadal, R.C., Rigby, S.E.J., Viles, J.H., (2004) J. Biol. Chem, 279, pp. 18169-18177

Kowalik-Jankowska, T., Ruta-Dolejsz, M., Wisniewska, K., Lankiewicz, L., Kozlowski, H., (2000) J. Chem. Soc., Dalton Trans, 4511, p. 4519

Burkoth, T.S., Benzinger, T.L.S., Jones, D.N.M., Hallenga, K., Meredith, S.C., Lynn, D.G., (1998) J. Am. Chem. Soc, 120, pp. 7655-7656

Irving, H., Miles, G., Malcolm, G., Pettit, L.D., (1967) Anal. Chim. Acta, 38, pp. 475-488

Zékány, L., Nagypál, I., (1985) Computational Methods for the Determination of Formation Constants, pp. 291-355. , Leggett, D. J. Ed, Plenum Press: New York

Gans, P., Sabatini, A., Vacca, A., (1985) J. Chem. Soc., Dalton Trans, pp. 1195-1200

Sigel, H., Martin, R.B., (1982) Chem. Rev, 82, pp. 385-426

Sóvágó, I., (1990) Biocoordination Chemistry: Metal Complexes of Peptides and Derivatives, pp. 135-184. , Burger, K. Ed, Ellis Horwood: Chichester, U.K

Kozlowski, H., Bal, W., Dyba, M., Kowalik-Jankowska, T., (1999) Coord. Chem. Rev, 184, pp. 319-346

Sóvágó, I., Ösz, K., (2006) Dalton Trans, pp. 3841-3854

Kállay, C., Várnagy, K., Micera, G., Sanna, D., Sóvágó, I., (2005) J. Inorg. Biochem, 99, pp. 1514-1525

Sóvágó, I., Sanna, D., Dessi, A., Várnagy, K., Micera, G., (1996) J. Inorg. Biochem, 63, pp. 99-117

Di Natale, G., Grasso, G., Impellizzeri, G., La Mendola, D., Micera, G., Mihala, N., Nagy, Z., Sóvágó, I., (2005) Inorg. Chem, 44, pp. 7214-7225

Grasso, D., Grasso, G., Guantieri, V., Impellizzeri, G., La Rosa, C., Milardi, D., Micera, G., Sóvágó, I., (2006) Chem. - Eur. J, 12, pp. 537-547

Jószai, V., Nagy, Z., Ösz, K., Sanna, D., Di Natale, G., La Mendola, D., Pappalardo, G., Sóvágó, I., (2006) J. Inorg. Biochem, 100, pp. 1399-1409

Sóvágó, I., Kiss, T., Gergely, A., (1993) Pure Appl. Chem, 65, pp. 1029-1080

Várnagy, K., Szabó, J., Sóvágó, I., Malandrinos, G., Hadjiliadis, N., Sanna, D., Micera, G., (2000) J. Chem. Soc., Dalton Trans, pp. 467-472

Bóka, B., Myari, A., Sóvágó, I., Hadjiliadis, N., (2004) J. Inorg. Biochem, 98, pp. 113-122

Kiss, T., Szücs, Z.J., (1986) Chem. Soc. Dalton Trans, pp. 2443-2447

Ösz, K., Nagy, Z., Pappalardo, G., Di Natale, G., Sanna, D., Micera, G., Rizzarelli, E., Sóvágó, I., (2007) Chem. - Eur. J, 13, pp. 7129-7143

Petkova, A.T., Ishii, Y., Balbach, J.J., Antzutkin, O.N., Leapman, R.D., Delaglio, F., Tycko, R., (2002) PNAS, 99, pp. 16742-16747

Kheterpal, I., Williams, A., Murphy, C., Bledsoe, B., Wetzel, R., (2001) Biochemistry, 40, pp. 11757-11767

McLaurin, J., Cecal, R., Kierstead, M.E., Tian, X., Phinney, A.L., Manea, M., French, J.E., St George-Hyslop, P., (2002) Nat. Med, 8, pp. 1263-1269

Frenkel, D., Balass, M., Solomon, B., (1998) J. Neuroimmunol, 88, pp. 85-90

Frenkel, D., Dewachter, I., Van Leuven, F., Solomon, B., (2003) Vaccine, 21, pp. 1060-1065

Chauhan, N.B., Siegel, G.J., (2005) Neurosci. Lett, 375, pp. 143-147

Zirah, S., Stefanescu, R., Manea, M., Tian, X., Cecal, R., Kozin, S.A., Debey, P., Przybylski, M., (2004) Biochem. Biophys. Res. Commun, 321, pp. 324-328

Seabrook, T.J., Thomas, K., Jiang, L., Bloom, J., Spooner, E., Maier, M., Bitan, G., Lemere, C.A., (2007) Neurobiol. Aging, 28, pp. 813-823

Rickard, G.A., Gomez-Balderas, R., Brunelle, P., Raffa, D.F., Rauk, A., (2005) J. Phys. Chem. A, 109, pp. 8361-3370

Guilloreau, L., Damian, L., Coppel, Y., Mazarguil, H., Winterhalter, M., Faller, P., (2006) J. Biol. Inorg. Chem, 11, pp. 1024-1038

Klaim, W.L., Krafft, G.A., Finch, C.E., (2001) Trends Neurosci, 24, pp. 219-224

Lashuel, H.A., Hartley, D., Petre, B.M., Walz, T., Lansbury Jr., P.T., (2002) Nature, 418, p. 291

Hoshi, M., Sato, M., Matsumoto, S., Noguchi, A., Yasutake, K., Yoshida, N., Sato, K., (2003) Proc. Natl. Acad. Sci. U.S.A, 100, pp. 6370-6375

Cleary, J.P., Walsh, D.M., Hofmeister, J.J., Shankar, G.M., Kuskowski, M.A., Selkoe, D.J., Ashe, K.H., (2005) Nat. Neurosci, 8, pp. 79-84

Lue, L.F., Kuo, Y.M., Roher, A.E., Brachova, L., Shen, Y., Sue, L., Beach, T., Rogers, J., (1999) Am. J. Pathol, 155, pp. 853-862

Yoshiike, Y., Tanemura, K., Murayama, O., Akagi, T., Murayama, M., Sato, S., Sun, X., Takashima, A., (2001) J. Biol. Chem, 276, pp. 32293-32299

Kirkitadze, M.D., Bitan, G., Teplow, D.B., (2002) J. Neurosci. Res, 69, pp. 567-577

Smith, D.P., Cicciotosto, G.D., Tew, D.J., Fodero-Tavoletti, M.T., Johanssen, T., Masters, C.L., Barnham, K.J., Cappai, R., (2007) Biochemistry, 46, pp. 2881-2891

Karr, J.W., Szalai, V.A., (2008) Biochemistry, 47, pp. 5006-5016

Hatcher, L.Q., Hong, L., Bush, W.D., Carducci, T., Simon, J.D., (2008) J. Phys. Chem. B, 112, pp. 8160-8164

Anfisen, C. B., (1973) Science, 181, pp. 223-23

Ellis, R. J., Pinheiro, T. J., (2002) Nature, 416, pp. 483-484

Kelly, J. W., (1998) Curr. Opin. Struct. Biol, 8, pp. 101-106

Dobson, C. M., (1999) Trends Biochem. Sci, 24, pp. 329-332

Carrell, R. V., Lomas, D. A., (1997) Lancet, 350, pp. 134-138

Berke, S. J. S., Paulson, H. L., (2003) Curr. Opin. Genet. Dev, 13, pp. 253-261

Selkoe, D. J., (1999) Nature, 399, pp. 23-31

Glenner, G. G., Wong, C. W., (1984) Biochem Biophys. Res. Commun, 122, pp. 1131-1135

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., Beyreuther, K., (1985) Proc. Natl. Acad. Sci. U. S. A, 82, pp. 4245-4249

Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., Cotman, C. W., (1993) J. Neurosci, 13, pp. 1676-1687

Yankner, B. A., (1996) Neuron, 16, pp. 921-932

Walsh, D. M., Hartley, D. M., Kusumoto, Y., Fezoni, Y., Condron, M. M., Lomakin, A., Benedek, G. B., Teplow, D. B., (1999) J. Biol. Chem, 274, pp. 25945-25952

Fraser, P. E., Nguyen, J. T., Surewicz, W. K., Selkoe, D. J., Podlisny, M. B., Kirshner, D. A., (1992) Biochemistry, 31, pp. 10716-10723

Yip, C. M., Darabie, A. A., McLaurin, J., (2002) J. Mol. Biol, 318, pp. 97-107

Ambroggio, E. E., Kim, D. H., Separovic, F., Barrow, C. J., Barnham, K. J., Bagatolli, L. A., Fedelio, G. D., (2005) Biophys. J, 88, pp. 2706-2713

Vitek, M. P., Bhattacharia, K., Glendening, J. M., Stopa, E., Vlassara, H., Bucala, R., Manogue, K., Cerami, A., (1994) Proc. Natl. Acad. Sci. U. S. A, 91, pp. 4766-4770

Bush, A. I., Petringell, W. H., Multhaup, G., de Paradis, M., Vonsattel, J. P., Gusella, J. F., Beyreuther, K., Tanzi, R. E., (1994) Science, 265, pp. 1464-1467

Atwood, C. S., Moir, R. D., Huang, X., Scarpa, R. C., Bacarra, N. M., Romano, D. M., Harthorn, M. A., Bush, A. I., (1998) J. Biol. Chem, 273, pp. 12817-12826

Bush, A. I., (2003) Trends Neurosci, 26, pp. 207-214

Maynard, C. J., Bush, A. I., Masters, C. L., Cappai, R., Li, Q. -X., (2005) Int. J. Exp. Path, 86, pp. 147-159

White, A. R., Barnham, K. J., Bush, A. I., (2006) Expert Rev. Neurother, 6, pp. 711-722

Lovell, M. A., Robertson, J. D., Teesdale, W. J., Markesbery, W. R., (1998) J. Neurol. Sci, 158, pp. 47-52

Miller, L. M., Wang, Q., Telivala, T. P., Smith, R. J., Lanzirotti, A., Miklossy, J., (2006) J. Struct. Biol, 155, pp. 30-37

Lee, J. Y., Cole, T. B., Palmiter, R. D., Suh, S. W., Koh, J. Y., (2002) Proc. Natl. Acad. Sci. U. S. A, 99, pp. 7705-7710

Sparks, D. L., Schreurs, B. G., (2003) Proc. Natl. Acad. Sci. U. S. A, 100, pp. 11065-11069

Bayer, T. A., Schafer, S., Simons, S., Kemmling, A., Kamer, T., Tepest, R., Eckert, A., Multhaup, G., (2003) Proc. Natl. Acad. Sci. U. S. A, 100, pp. 14187-14192

Phinney, A. L., Drisaldi, B., Schmidt, S. D., Lugowski, S., Coronado, V., Liang, Y., Horne, P., Westaway, D., (2003) Proc. Natl. Acad. Sci. U. S. A, 100, pp. 14193-14198

Cuajungco, M. P., Faget, K. Y., (2003) Brain Res. Rev, 41, pp. 44-56

Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Bush, A. I., (2001) Neuron, 30, pp. 665-676

Finefrock, A. E., Bush, A. I., Doraiswamy, P. M., (2003) J. Am. Geriatr. Soc, 51, pp. 1143-1148

Smith, D. P., Smith, D. G., Curtain, C. C., Boas, J. F., Pilbrow, J. R., Ciccotosto, G. D., Lau, T. -L., Barnham, K. J., (2006) J. Biol. Chem, 281, pp. 15145-15154

Karr, J. W., Akintoye, H., Kaupp, L. J., Szalai, V. A., (2005) Biochemistry, 44, pp. 5478-5487

Kozin, S. A., Zirah, S., Rebuffat, S., Hui Bon Hoa, G., Debey, P., (2001) Biochem. Biophys. Res. Commun, 285, pp. 959-964

Curtain, C. C., Ali, F., Volitakis, I., Cherny, R. A., Norton, R. S., Beyreuther, K., Barrow, C. J., Barnham, K. J., (2001) J. Biol. Chem, 276, pp. 20466-20473

Atwood, C. S., Scarpa, R. C., Huang, X., Moir, R. D., Jones, W. D., Fairlie, D. P., Tanzi, R. E., Bush, A. I., (2000) J. Neurochem, 75, pp. 1219-1233

Ma, Q. -F., Hu, J., Wu, W. -H., Liu, H. -D., Fu, Y., Wu, Y. -W., Lei, P., Li, Y. -M., (2006) Biopolymers, 83, pp. 20-31

Syme, C. D., Nadal, R. C., Rigby, S. E. J., Viles, J. H., (2004) J. Biol. Chem, 279, pp. 18169-18177

Burkoth, T. S., Benzinger, T. L. S., Jones, D. N. M., Hallenga, K., Meredith, S. C., Lynn, D. G., (1998) J. Am. Chem. Soc, 120, pp. 7655-7656

Z k ny, L., Nagyp l, I., (1985) Computational Methods for the Determination of Formation Constants, pp. 291-355. , Leggett, D. J. Ed, Plenum Press: New York

S v g, I., (1990) Biocoordination Chemistry: Metal Complexes of Peptides and Derivatives, pp. 135-184. , Burger, K. Ed, Ellis Horwood: Chichester, U. K

S v g, I., sz, K., (2006) Dalton Trans, pp. 3841-3854

K llay, C., V rnagy, K., Micera, G., Sanna, D., S v g, I., (2005) J. Inorg. Biochem, 99, pp. 1514-1525

S v g, I., Sanna, D., Dessi, A., V rnagy, K., Micera, G., (1996) J. Inorg. Biochem, 63, pp. 99-117

J szai, V., Nagy, Z., sz, K., Sanna, D., Di Natale, G., La Mendola, D., Pappalardo, G., S v g, I., (2006) J. Inorg. Biochem, 100, pp. 1399-1409

S v g, I., Kiss, T., Gergely, A., (1993) Pure Appl. Chem, 65, pp. 1029-1080

V rnagy, K., Szab, J., S v g, I., Malandrinos, G., Hadjiliadis, N., Sanna, D., Micera, G., (2000) J. Chem. Soc., Dalton Trans, pp. 467-472

B ka, B., Myari, A., S v g, I., Hadjiliadis, N., (2004) J. Inorg. Biochem, 98, pp. 113-122

Kiss, T., Sz cs, Z. J., (1986) Chem. Soc. Dalton Trans, pp. 2443-2447

sz, K., Nagy, Z., Pappalardo, G., Di Natale, G., Sanna, D., Micera, G., Rizzarelli, E., S v g, I., (2007) Chem. - Eur. J, 13, pp. 7129-7143

Petkova, A. T., Ishii, Y., Balbach, J. J., Antzutkin, O. N., Leapman, R. D., Delaglio, F., Tycko, R., (2002) PNAS, 99, pp. 16742-16747

Chauhan, N. B., Siegel, G. J., (2005) Neurosci. Lett, 375, pp. 143-147

Seabrook, T. J., Thomas, K., Jiang, L., Bloom, J., Spooner, E., Maier, M., Bitan, G., Lemere, C. A., (2007) Neurobiol. Aging, 28, pp. 813-823

Rickard, G. A., Gomez-Balderas, R., Brunelle, P., Raffa, D. F., Rauk, A., (2005) J. Phys. Chem. A, 109, pp. 8361-3370

Klaim, W. L., Krafft, G. A., Finch, C. E., (2001) Trends Neurosci, 24, pp. 219-224

Lashuel, H. A., Hartley, D., Petre, B. M., Walz, T., Lansbury Jr., P. T., (2002) Nature, 418, p. 291

Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J., Ashe, K. H., (2005) Nat. Neurosci, 8, pp. 79-84

Lue, L. F., Kuo, Y. M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Rogers, J., (1999) Am. J. Pathol, 155, pp. 853-862

Kirkitadze, M. D., Bitan, G., Teplow, D. B., (2002) J. Neurosci. Res, 69, pp. 567-577

Smith, D. P., Cicciotosto, G. D., Tew, D. J., Fodero-Tavoletti, M. T., Johanssen, T., Masters, C. L., Barnham, K. J., Cappai, R., (2007) Biochemistry, 46, pp. 2881-2891

Karr, J. W., Szalai, V. A., (2008) Biochemistry, 47, pp. 5006-5016

Hatcher, L. Q., Hong, L., Bush, W. D., Carducci, T., Simon, J. D., (2008) J. Phys. Chem. B, 112, pp. 8160-8164

The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue

Alzheimer's disease (AD) is becoming a rapidly growing health problem, as it is one of the main causes of dementia in the elderly. Interestingly, copper (II) (together with zinc and iron) ions are accumulated in amyloid deposits, suggesting that metal binding to A beta could be involved in AD pathogenesis. In A beta, the metal binding is believed to occur within the N-terminal region encompassing the amino acid residues 1-16. In this work, potentiometric, spectroscopic (UV-vis, circular dichroism, and electron paramagnetic resonance), and electrospray ionization mass spectrometry (ESI-MS) approaches were used to investigate the copper (II) coordination features of a new polyethylene glycol (PEG) -conjugated A beta peptide fragment encompassing the 1-16 amino acid residues of the N-terminal region (A beta (1 - 16) PEG). The high water solubility of the resulting metal complexes allowed us to obtain a complete complex speciation at different metal-to-ligand ratios ranging from 1: 1 to 4: 1. Potentiometric and ESI-MS data indicate that A beta (1-16) PEG is able to bind up to four copper (II) ions. Furthermore, in order to establish the coordination environment at each metal binding site, a series of shorter peptide fragments of A beta, namely, A beta (1-4), A beta (1-6), AcA beta (1-6), and AcA beta (8-16) Y10A, were synthesized, each encompassing a potential copper (II) binding site. The complexation properties of these shorter peptides were also comparatively investigated by using the same experimental approach
The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue

No results.
The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue

Filter those results▼
Query:  [X]
Options:
   Extended  
   IBB affiliation
 
Authors:  [X]
Paper type:  [X]
Start date:  [X]
End date:  [X]
Site:
[Clear form]
Select the year: 
Other filter: ([btitle,keywords] "Amyloid Beta Protein ...

Sort by:   date ▼▲   title ▲ ▼   journal ▲ ▼   authors ▲ ▼   I.F. ▲ ▼
Iaccarino E, Sandomenico A, Corvino G, Foca G, Severino V, Russo R, Caporale A, Raimondo D, D'Abramo M, Alba J, Chambery A, Ruvo M
* Investigating the oxidative refolding mechanism of Cripto-1 CFC domain (320 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Sep 15; 137: 1179-1189.
Impact Factor: 4.784
View    Export to BibTeX    Export to EndNote

Mercurio FA, Scaloni A, Caira S, Leone M
* The antimicrobial peptides casocidins I and II: Solution structural studies in water and different membrane-mimetic environments (277 views)
Peptides (ISSN: 0196-9781linking, 1873-5169electronic), 2018 Sep 19; 114: 50-58.
Impact Factor: 2.851
View    Export to BibTeX    Export to EndNote

Sciacca MFM, Monaco I, La Rosa C, Milardi D
* The active role of Ca(2+) ions in Abeta-mediated membrane damage (309 views)
Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2018 Apr 5; 54(29): 3629-3631.
Impact Factor: 6.169
View    Export to BibTeX    Export to EndNote

Venuta A, Moret F, Dal Poggetto G, Esposito D, Fraix A, Avitabile C, Ungaro F, Malinconico M, Sortino S, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Shedding light on surface exposition of poly(ethylene glycol) and folate targeting units on nanoparticles of poly(ε-caprolactone) diblock copolymers: Beyond a paradigm (549 views)
Eur J Pharm Sci (ISSN: 0928-0987, 0928-0987linking), 2018 Jan 1; 111: 177-185.
Impact Factor: 0
View    Export to BibTeX    Export to EndNote

Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (362 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
View    Export to BibTeX    Export to EndNote

Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (538 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
View    Export to BibTeX    Export to EndNote

Magri A, Pietropaolo A, Tabbì G, La Mendola D, Rizzarelli E
* From Peptide Fragments to Whole Protein: Copper(II) Load and Coordination Features of IAPP (584 views) (PDF 116 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 Dec 19; 23(71): 17898-17902.
Impact Factor: 5.16
View    Export to BibTeX    Export to EndNote

Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E
* Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (727 views) (PDF 197 views)
Aging Cell (ISSN: 1474-9726, 1474-9718linking), 2017 Nov 01; 17(1): N/D-N/D.
Impact Factor: 7.627
View    Export to BibTeX    Export to EndNote

Di Natale G, Bellia F, Sciacca F, Campagna T, Pappalardo G
* Tau-peptide fragments and their copper(II) complexes: Effects on Amyloid-beta aggregation (406 views)
Inorganica Chimica Acta, 2017 Sep; N/D: N/D-N/D.
Impact Factor: 2.002
View    Export to BibTeX    Export to EndNote

Mercurio FA, Costantini S, Di Natale C, Pirone L, Guariniello S, Scognamiglio PL, Marasco D, Pedone EM, Leone M
* Structural investigation of a C-terminal EphA2 receptor mutant: Does mutation affect the structure and interaction properties of the Sam domain? (332 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639linking), 2017 Jun 06; 1865(9): 1095-1104.
Impact Factor: 4.28
View    Export to BibTeX    Export to EndNote

Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (752 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
View    Export to BibTeX    Export to EndNote

Scognamiglio PL, Di Natale C, Leone M, Cascella R, Cecchi C, Lirussi L, Antoniali G, Riccardi D, Morelli G, Tell G, Chiti F, Marasco D
* Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia (396 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2016 Sep 13; 7(37): 59129-59143.
Impact Factor: 5.168
View    Export to BibTeX    Export to EndNote

Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PLS, Carrotta R
* Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains (363 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2016; 208: 9-16.
Impact Factor: 2.402
View    Export to BibTeX    Export to EndNote

Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (526 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
View    Export to BibTeX    Export to EndNote

Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (758 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
View    Export to BibTeX    Export to EndNote

Di Natale G, Turi I, Pappalardo G, Sóvágó I, Rizzarelli E
* Cross-Talk Between the Octarepeat Domain and the Fifth Binding Site of Prion Protein Driven by the Interaction of Copper(II) with the N-terminus (454 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Mar 2; 21(10): 4071-4084.
Impact Factor: 5.771
View    Export to BibTeX    Export to EndNote

Calvanese L, Sandomenico A, Caporale A, Foca A, Foca G, D'Auria G, Falcigno L, Ruvo M
* Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments (496 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015 Jan 15; 21(4): 283-293.
Impact Factor: 1.951
View    Export to BibTeX    Export to EndNote

Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo  G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
* Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity (462 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015 Jan; 142: 39-46.
Impact Factor: 3.205
View    Export to BibTeX    Export to EndNote

Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
View    Export to BibTeX    Export to EndNote

Tomasello MF, Sinopoli A, Pappalardo G
* On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides (443 views)
J Diabetes Res (ISSN: 2314-6745, 2314-6745print), 2015; articleID918573: 918573-918573.
Impact Factor: 2.431
View    Export to BibTeX    Export to EndNote

Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (464 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2015; 16(11): 1629-1636.
Impact Factor: 2.85
View    Export to BibTeX    Export to EndNote

Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (527 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
View    Export to BibTeX    Export to EndNote

Carotenuto A, Auriemma L, Merlino F, Yousif AM, Marasco D, Limatola A, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P
* Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor (672 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2014 Jul 24; 57(14): 5965-5974.
Impact Factor: 5.447
View    Export to BibTeX    Export to EndNote

Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
View    Export to BibTeX    Export to EndNote

Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (1043 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
View    Export to BibTeX    Export to EndNote

Federico A, Zappavigna S, Romano  M, Grieco P, Luce A, Marra M, Gravina AG, Stiuso P, D'Armiento FP, Vitale G, Tuccillo C, Novellino E, Loguercio C, Caraglia M
* Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans (444 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2014 Mar; 44(3): 285-294.
Impact Factor: 2.734
View    Export to BibTeX    Export to EndNote

Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (560 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
View    Export to BibTeX    Export to EndNote

Travaglia A, La Mendola D, Magrì A, Pietropaolo A, Nicoletti VG, Grasso G, Malgieri G, Fattorusso R, Isernia C, Rizzarelli E
* Zinc(II) interactions with brain-derived neurotrophic factor N-terminal peptide fragments: inorganic features and biological perspectives (419 views)
Inorg Chem (ISSN: 1520-510x, 0020-1669, 1520-510xelectronic), 2013 Oct 7; 52(19): 11075-11083.
Impact Factor: 4.794
View    Export to BibTeX    Export to EndNote

Farina B, Doti N, Pirone L, Malgieri G, Pedone E, Ruvo M, Fattorusso R
* Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy (468 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Sep; 1834(8): 1572-1580.
Impact Factor: 3.191
View    Export to BibTeX    Export to EndNote

Russo L, Raiola L, Campitiello MA, Magrì A, Fattorusso R, Malgieri G, Pappalardo G, La Mendola D, Isernia C
* Probing the residual structure in avian prion hexarepeats by CD, NMR and MD techniques (418 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2013 Sep; 18(9): 11467-11484.
Impact Factor: 2.095
View    Export to BibTeX    Export to EndNote

Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (500 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
View    Export to BibTeX    Export to EndNote

Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (537 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
View    Export to BibTeX    Export to EndNote

Carotenuto A, Auriemma L, Merlino F, Limatola A, Campiglia P, Gomez-monterrey I, Di Villa Bianca R, Brancaccio D, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P
* New insight into the binding mode of peptides at urotensin-II receptor by Trp-constrained analogues of P5U and urantide (518 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387electronic, 1075-2617linking), 2013 May; 19(5): 293-300.
Impact Factor: 1.862
View    Export to BibTeX    Export to EndNote

Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (697 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
View    Export to BibTeX    Export to EndNote

Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (888 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Mar; 19(3): 148-158.
Impact Factor: 1.862
View    Export to BibTeX    Export to EndNote

Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (628 views)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
View    Export to BibTeX    Export to EndNote

De Rosa L, Russomanno A, Romanelli A, D'Andrea LD
* Semi-Synthesis of Labeled Proteins for Spectroscopic Applications (461 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2013 Jan; 18(1): 440-465.
Impact Factor: 2.095
View    Export to BibTeX    Export to EndNote

Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (728 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
View    Export to BibTeX    Export to EndNote

Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (456 views)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
View    Export to BibTeX    Export to EndNote

Bellia F, Pietropaolo A,  Grasso G
* Formation of insulin fragments by insulin-degrading enzyme: The role of zinc(II) and cystine bridges (450 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2013; 48(2): 135-140.
Impact Factor: 2.709
View    Export to BibTeX    Export to EndNote

Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (572 views)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
View    Export to BibTeX    Export to EndNote

Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (506 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
View    Export to BibTeX    Export to EndNote

Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1070 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
View    Export to BibTeX    Export to EndNote

Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
View    Export to BibTeX    Export to EndNote

Arena G, La Mendola D, Pappalardo G, Sovago I, Rizzarelli E
* Interactions of Cu 2+ with prion family peptide fragments: Considerations on affinity, speciation and coordination (489 views)
Coord Chem Rev (ISSN: 0010-8545), 2012 Oct; 256(19-20): 2202-2218.
Impact Factor: 11.016
View    Export to BibTeX    Export to EndNote

Tagliamonte M, Marasco D, Ruggiero A, de Stradis A, Tornesello ML, Totrov M, Buonaguro FM, Buonaguro L
* HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens (405 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Sep 17; 7(8): N/D-N/D.
Impact Factor: 3.73
View    Export to BibTeX    Export to EndNote

Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (603 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
View    Export to BibTeX    Export to EndNote

Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (932 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
View    Export to BibTeX    Export to EndNote

Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
* Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein (481 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jul; 112: 17-24.
Impact Factor: 3.197
View    Export to BibTeX    Export to EndNote

La Mendola D, Magrì A, Santoro AM, Nicoletti VG, Rizzarelli E
* Copper(II) interaction with peptide fragments of histidine-proline-rich glycoprotein: Speciation, stability and binding details (404 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 59-69.
Impact Factor: 3.197
View    Export to BibTeX    Export to EndNote

Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
View    Export to BibTeX    Export to EndNote

La Mendola D, Farkas D, Bellia F, Magri A, Travaglia A, Hansson O, Rizzarelli E
* Probing the copper(II) binding features of angiogenin. Similarities and differences between a N-terminus peptide fragment and the recombinant human protein (388 views)
Inorg Chem (ISSN: 1520-510x, 0020-1669, 1520-510xelectronic), 2012 Jan 2; 51(1): 128-141.
Impact Factor: 4.593
View    Export to BibTeX    Export to EndNote

Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (987 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View    Export to BibTeX    Export to EndNote

Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (381 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
View    Export to BibTeX    Export to EndNote

Satriano C, Fragalà ME, Forte G, Santoro AM, La Mendola D, Kasemo B
* Surface adsorption of fibronectin-derived peptide fragments: The influence of electrostatics and hydrophobicity for endothelial cells adhesion (307 views)
Soft Matter (ISSN: 1744-683x), 2012; 8(1): 53-56.
Impact Factor: 3.909
View    Export to BibTeX    Export to EndNote

Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (455 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
View    Export to BibTeX    Export to EndNote

Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (561 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
View    Export to BibTeX    Export to EndNote

Kállay C, Turi I, Timári S, Nagy Z, Sanna D, Pappalardo G, De Bona P, Rizzarelli E, Sóvágó I
* The effect of point mutations on copper(II) complexes with peptide fragments encompassing the 106-114 region of human prion protein (503 views)
Monatshefte Fur Chemie (ISSN: 0026-9247), 2011 Apr; 142(4): 411-419.
Impact Factor: 1.532
View    Export to BibTeX    Export to EndNote

Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E
* The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor (498 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Mar 21; 17(13): 3726-3738.
Impact Factor: 5.925
View    Export to BibTeX    Export to EndNote

Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (553 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
View    Export to BibTeX    Export to EndNote

Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (492 views)
Mol Biosyst (ISSN: 1742-206x), 2011 Mar; 7(3): 862-870.
Impact Factor: 3.534
View    Export to BibTeX    Export to EndNote

Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View    Export to BibTeX    Export to EndNote

Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (576 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
View    Export to BibTeX    Export to EndNote

Milardi D, Sciacca MFM, Pappalardo M, Grasso DM, La Rosa C
* The Role Of Aromatic Side-Chains In Amyloid Growth And Membrane Interaction Of The Islet Amyloid Polypeptide Fragment Lanflvh (457 views)
Eur Biophys J, 2011 Jan; 40(1): 1-12.
Impact Factor: 3.832
View    Export to BibTeX    Export to EndNote

Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (480 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
View    Export to BibTeX    Export to EndNote

Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
View    Export to BibTeX    Export to EndNote

Turi I, Kállay C, Szikszai D, Pappalardo G, Di Natale G, De Bona P, Rizzarelli E, Sóvágó I
* Nickel(II) complexes of the multihistidine peptide fragments of human prion protein (480 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2010 Sep; 104(8): 885-891.
Impact Factor: 3.317
View    Export to BibTeX    Export to EndNote

Guarnieri D, De Capua A, Ventre M, Borzacchiello A, Pedone C, Marasco D, Ruvo M, Netti PA
* Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters (580 views)
Acta Biomaterialia (ISSN: 1878-7568, 1742-7061), 2010 Jul; 6(7): 2532-2539.
Impact Factor: 4.824
View    Export to BibTeX    Export to EndNote

La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1115 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
View    Export to BibTeX    Export to EndNote

Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (835 views)
Cell Mol Life Sci (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
Impact Factor: 7.047
View    Export to BibTeX    Export to EndNote

Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
View    Export to BibTeX    Export to EndNote

Mazzaglia A, Micali N, Scolaro LM, Attanasio F, Magrí A, Pappalardo G, Villari V
* Aggregation properties of the peptide fragments derived from the 17-29 region of the human and rat IAPP: A comparative study with two PEG-conjugated variants of the human sequence (440 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Jan 21; 114(2): 705-713.
Impact Factor: 3.603
View    Export to BibTeX    Export to EndNote

Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
* Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (534 views)
J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
Impact Factor: 3.068
View    Export to BibTeX    Export to EndNote

Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
View    Export to BibTeX    Export to EndNote

Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (675 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
View    Export to BibTeX    Export to EndNote

Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (465 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
View    Export to BibTeX    Export to EndNote

Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (659 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
View    Export to BibTeX    Export to EndNote

Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (610 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
View    Export to BibTeX    Export to EndNote

Palladino P, Ronga L, Benedetti E, Rossi F, Ragone R
* Peptide Fragment Approach to Prion Misfolding: The Alpha-2 Domain (401 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2009 Sep; 15(3): 165-176.
Impact Factor: 0.869
View    Export to BibTeX    Export to EndNote

Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (490 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
View    Export to BibTeX    Export to EndNote

Di Natale G, Osz K, Nagy Z, Sanna D, Micera G, Pappalardo G, Sovago I, Rizzarelli E
* The Interaction Of Copper (ii) With The Prion Peptide Fragment Huprp (76-114) Encompassing Four Histidyl Residues Within And Outside The Octarepeat Domain (323 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 May 4; 48(9): 4239-4250.
Impact Factor: 4.657
View    Export to BibTeX    Export to EndNote

La Mendola D, Magrì A, Hansson O, Bonomo RP, Rizzarelli E
* Copper(II) complexes with peptide fragments encompassing the sequence 122-130 of human doppel protein (361 views)
Journal Of Inorganic Biochemistry, 2009 May; 103(5): 758-765.
Impact Factor: 3.444
View    Export to BibTeX    Export to EndNote

Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
View    Export to BibTeX    Export to EndNote

De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (688 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
View    Export to BibTeX    Export to EndNote

D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (486 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
View    Export to BibTeX    Export to EndNote

Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (454 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View    Export to BibTeX    Export to EndNote

La Mendola D, Bonomo RP, Caminati S, Di Natale G, Emmi SS, Hansson O, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E
* Copper(II) complexes with an avian prion N-terminal region and their potential SOD-like activity (393 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2009 Feb; 103(2): 195-204.
Impact Factor: 3.252
View    Export to BibTeX    Export to EndNote

Francalanci F, Avolio M, De Luca E, Longo DL, Menchise V, Guazzi P, Sgro F, Marino M, Goitre L, Balzac F, Trabalzini L, Retta SF
* Structural and functional differences between KRIT1A and KRIT1B isoforms: A framework for understanding CCM pathogenesis (493 views)
Exp Cell Res (ISSN: 0014-4827), 2009 Jan 15; 315(2): 285-303.
Impact Factor: 3.589
View    Export to BibTeX    Export to EndNote

Ronga L, Palladino P, Ragone R, Benedetti E, Rossi F
* A thermodynamic approach to the conformational preferences of the 180-195 segment derived from the human prion protein α2-helix (286 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009; 15(1): 30-35.
Impact Factor: 1.807
View    Export to BibTeX    Export to EndNote

Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (388 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
View    Export to BibTeX    Export to EndNote

Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (402 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
View    Export to BibTeX    Export to EndNote

Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
* Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity (456 views)
Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2008 Sep; 29(9): 1461-1471.
Impact Factor: 2.565
View    Export to BibTeX    Export to EndNote

Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (408 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
View    Export to BibTeX    Export to EndNote

Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (391 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
View    Export to BibTeX    Export to EndNote

Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
* The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (462 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2008 Mar 25; 9(5): 758-767.
Impact Factor: 3.322
View    Export to BibTeX    Export to EndNote

Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (367 views)
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.
Impact Factor: 0.481
View    Export to BibTeX    Export to EndNote

Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (507 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
View    Export to BibTeX    Export to EndNote

D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
View    Export to BibTeX    Export to EndNote

Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View    Export to BibTeX    Export to EndNote

Grasso G, Rizzarelli E, Spoto G
* AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin (508 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2007 Dec; 42(12): 1590-1598.
Impact Factor: 3.062
View    Export to BibTeX    Export to EndNote

Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (584 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
Impact Factor: 3.446
View    Export to BibTeX    Export to EndNote

Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
View    Export to BibTeX    Export to EndNote

Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (400 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
View    Export to BibTeX    Export to EndNote

Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View    Export to BibTeX    Export to EndNote

Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (613 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
View    Export to BibTeX    Export to EndNote

Osz K, Nagy Z, Pappalardo G, Di Natale G, Sanna D, Micera G, Rizzarelli E, Sóvágó I
* Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details (549 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(25): 7129-7143.
Impact Factor: 5.33
View    Export to BibTeX    Export to EndNote

Pappalardo G, Milardi D, Magrì A, Attanasio F, Impellizzeri G, La Rosa C, Grasso D, Rizzarelli E
* Environmental factors differently affect human and rat IAPP: Conformational preferences and membrane interactions of IAPP17-29 peptide derivatives (607 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(36): 10204-10215.
Impact Factor: 5.33
View    Export to BibTeX    Export to EndNote

Joszal V, Nagy Z, Osz K, Sanna D, Di Natale G, La Mendola D, Pappalardo G, Rizzarelli E, Sovago I
* Transition metal complexes of terminally protected peptides containing histidyl residues (513 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2006 Sep; 100(8): 1399-1409.
Impact Factor: 2.654
View    Export to BibTeX    Export to EndNote

Langella E, Improta R, Crescenzi O, Barone V
* Assessing the acid-base and conformational properties of histidine residues in human prion protein (125-228) by means of pKα calculations and molecular dynamics simulations (580 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jul 1; 64(1): 167-177.
Impact Factor: 3.73
View    Export to BibTeX    Export to EndNote

Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View    Export to BibTeX    Export to EndNote

Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (544 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
View    Export to BibTeX    Export to EndNote

Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Micera G, Osz K, Pappalardo G, Rizzarelli E, Sanna D, Sovago I
* Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues (432 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2005 Dec 23; 12(2): 537-547.
Impact Factor: 4.907
View    Export to BibTeX    Export to EndNote

Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (377 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
View    Export to BibTeX    Export to EndNote

Di Natale G, Grasso G, Impellizzeri G, La Mendola D, Micera G, Mihala N, Nagy Z, Osz K, Pappalardo G, Rigó V, Rizzarelli E, Sanna D, Sóvágó I
* Copper(II) interaction with unstructured prion domain outside the octarepeat region: Speciation, stability, and binding details of copper(II) complexes with PrP106-126 peptides (3901 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2005 Oct 3; 44(20): 7214-7225.
Impact Factor: 3.851
View    Export to BibTeX    Export to EndNote

Galdiero S, Falanga A, Vitiello M, Browne H, Pedone C, Galdiero M
* Fusogenic domains in herpes simplex virus type 1 glycoprotein (590 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Sep 5; 280(31): 28632-28643.
Impact Factor: 5.854
View    Export to BibTeX    Export to EndNote

Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View    Export to BibTeX    Export to EndNote

La Mendola D, Bonomo RP, Impellizzeri G, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E, Zito V
* Copper(II) complexes with chicken prion repeats: Influence of proline and tyrosine residues on the coordination features (303 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2005 Sep; 10(5): 463-475.
Impact Factor: 3.224
View    Export to BibTeX    Export to EndNote

Esposito L, Daggett V
* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (438 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
Impact Factor: 3.848
View    Export to BibTeX    Export to EndNote

De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (359 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
View    Export to BibTeX    Export to EndNote

Di Natale G, Impellizzeri G, Pappalardo G
* Conformational properties of peptide fragments homologous to the 106-114 and 106-126 residues of the human prion protein: a CD and NMR spectroscopic study (424 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2005 Feb 7; 3(3): 490-497.
Impact Factor: 2.547
View    Export to BibTeX    Export to EndNote

Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (479 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
View    Export to BibTeX    Export to EndNote

Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View    Export to BibTeX    Export to EndNote

Falcigno L, Oliva R, D'Auria G, Maletta M, Dettin M, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site 3: Role of site-specific mutations (419 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Dec 3; 5(12): 1653-1661.
Impact Factor: 3.474
View    Export to BibTeX    Export to EndNote

Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (378 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
Impact Factor: 3.3
View    Export to BibTeX    Export to EndNote

Vitale RM, Pedone C, De Benedetti PG, Fanelli F
* Structural features of the inactive and active states of the melanin-concentrating hormone receptors: Insights from molecular simulations (491 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Sep 15; 56(3): 430-448.
Impact Factor: 4.429
View    Export to BibTeX    Export to EndNote

Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (543 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
View    Export to BibTeX    Export to EndNote

Grasso D, Milardi D, La Rosa C, Rizzarelli E
* The different role of Cu++ and Zn++ ions in affecting the interaction of prion peptide PrP106-126 with model membranes (283 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2004 Jan 21; 10(2): 246-247.
Impact Factor: 3.997
View    Export to BibTeX    Export to EndNote

Brown DR, Guantieri V, Grasso G, Impellizzeri G, Pappalardo G, Rizzarelli E
* Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region (495 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jan; 98(1): 133-143.
Impact Factor: 2.225
View    Export to BibTeX    Export to EndNote

Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
* Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (589 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
Impact Factor: 2.863
View    Export to BibTeX    Export to EndNote

De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
View    Export to BibTeX    Export to EndNote

Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (361 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Sep 4; 4(8): 727-733.
Impact Factor: 3.992
View    Export to BibTeX    Export to EndNote

Oliva R, Falcigno L, D'Auria G, Dettin M, Scarinci C, Pasquato A, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site, 2: relevance of an N-terminal helix (360 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Aug 4; 4(8): 727-733.
Impact Factor: 2.92
View    Export to BibTeX    Export to EndNote

De Luca S, Ragone R, Bracco C, Digilio G, Tesauro D, Saviano M, Pedone C, Morelli G
* The role of segment 32-47 of cholecystokinin receptor type A in CCK8 binding: Synthesis, nuclear magnetic resonance, circular dichroism and fluorescence studies (349 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Mar; 9(3): 156-169.
Impact Factor: 1.377
View    Export to BibTeX    Export to EndNote

Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (709 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
View    Export to BibTeX    Export to EndNote

Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (471 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
View    Export to BibTeX    Export to EndNote

Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (323 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
View    Export to BibTeX    Export to EndNote

Oliva R, Leone M, Falcigno L, D'Auria G, Dettin M, Scarinci C, Di Bello C, Paolillo L
* Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site (489 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002 Mar 15; 8(6): 1467-1473.
Impact Factor: 4.238
View    Export to BibTeX    Export to EndNote

Menchise V, De Simone G, Corradini R, Sforza S, Sorrentino N, Romanelli A, Saviano M, Pedone C
* Crystallization and preliminary X-ray diffraction studies of a D-lysine-based chiral PNA-DNA duplex (328 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2002 Mar; 58(3): 553-555.
Impact Factor: 1.76
View    Export to BibTeX    Export to EndNote

Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* Liganded and unliganded forms of Antarctic fish haemoglobins in polyethylene glycol: crystallization of an R-state haemichrome intermediate (392 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2001 Sep; 57: 1144-1146.
Impact Factor: 2.124
View    Export to BibTeX    Export to EndNote

Esposito L, Vitagliano L, Zagari A, Mazzarella L
Experimental evidence for the correlation of bond distances in peptide groups detected in ultrahigh-resolution protein structures (301 views)
Protein Eng (ISSN: 0269-2139, 0269-2139print, 0269-2139linking), 2000 Dec; 13(12): 825-828.
Impact Factor: 2.442
View    Export to BibTeX    Export to EndNote

Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (369 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
View    Export to BibTeX    Export to EndNote

Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (419 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 47-53.
Impact Factor: 2.405
View    Export to BibTeX    Export to EndNote

Fogliano V, Monti SM, Visconti A, Randazzo G, Facchiano AM, Colonna G, Ritieni A
Identification of a β-lactoglobulin lactosylation site (375 views)
Biochim Biophys Acta Protein Struct Mol Enzymol (ISSN: 0167-4838), 1998 Nov 10; 1388(2): 295-304.
Impact Factor: 1.687
View    Export to BibTeX    Export to EndNote

Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (430 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
View    Export to BibTeX    Export to EndNote

Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (484 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
View    Export to BibTeX    Export to EndNote

FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (446 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
View    Export to BibTeX    Export to EndNote

Pavone V, Rossi F, Pucci P, Andini S, Ferrara L, Di Blasio B, Pedone C
Studies on gliadin related peptides. I. Synthesis, purification and 1H n. m. r. characterization of the pentapeptide H-Tyr-(Gln)3-Pro-OH (1025 views)
Int J Pept Protein Res (ISSN: 0367-8377, 0367-8377print), 1983 Oct; 22(4): 482-488.
Impact Factor: 1.255
View    Export to BibTeX    Export to EndNote

147 Records (145 excluding Abstracts).
Total impact factor: 528.847 (521.025 excluding Abstracts).
Total 5 year impact factor: 558.603 (549.822 excluding Abstracts).

Last modified by Marco Comerci on Sunday 12 July 2020, 13:15:02
569 views. Last view on Thursday 19 January 2023, 14:37:36