Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD - cullin 3 recognition (373 views visite)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 373-376.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 1.799, 5-year impact factor Impact factor a 5 anni: 1.714
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79953802203&partnerID=40&md5=d9027cbb3a788f1ae3f940b9c088ce43
Keywords Parole chiave: Poz Btb Domains, Protein-Protein Recognition, Structure-Function Relationships, Ubiquitination, Cullin, Protein Kctd, Unclassified Drug, Article, Molecular Model, Peptide Analysis, Peptide Synthesis, Priority Journal, Protein Binding, Protein Domain, Protein Protein Interaction, Circular Dichroism, Cullin Proteins, Enzyme-Linked Immunosorbent Assay, Humans, Potassium Channels, Protein Structure, Secondary, Poxviridae,
Affiliations Affiliazioni:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR, 80134 Napoli, Italy
Department of Biological Sciences, Federico II University, 80134 Napoli, Italy
References Riferimenti:
Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K., Prive, G.G., Sequence and structural analysis of BTB domain proteins (2005) Genome Biol., 6, pp. R8
Zollman, S., Godt, D., Prive, G.G., Couderc, J.L., Laski, F.A., The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in drosophila (1994) Proc. Natl. Acad. Sci. U.S.A., 91, pp. 10717-10721
Bardwell, V.J., Treisman, R., The POZ domain: a conserved protein-protein interaction motif (1994) Genes Dev., 8, pp. 1664-1677
Melnick, A., Ahmad, K.F., Arai, S., Polinger, A., Ball, H., Borden, K.L., Carlile, G.W., Licht, J.D., In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions (2000) Mol. Cell Biol., 20, pp. 6550-6567
Kang, M.I., Kobayashi, A., Wakabayashi, N., Kim, S.G., Yamamoto, M., Scaffolding of keap1 to the actin cytoskeleton controls the function of nrf2 as key regulator of cytoprotective phase 2 genes (2004) Proc. Natl. Acad. Sci. U.S.A., 101, pp. 2046-2051
Minor, D.L., Lin, Y.F., Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y., Berger, J.M., The polar t1 interface is linked to conformational changes that open the voltage-gated potassium channel (2000) Cell, 102, pp. 657-670
Pintard, L., Willis, J.H., Willems, A., Johnson, J.L., Srayko, M., Kurz, T., Glaser, S., Peter, M., The BTB protein mel-26 is a substrate-specific adaptor of the cul-3 ubiquitin-ligase (2003) Nature, 425, pp. 311-316
Furukawa, M., He, Y.J., Borchers, C., Xiong, Y., Targeting of protein ubiquitination by BTB-cullin 3-roc1 ubiquitin ligases (2003) Nat. Cell Biol., 5, pp. 1001-1007
Geyer, R., Wee, S., Anderson, S., Yates, J., Wolf, D.A., BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases (2003) Mol. Cell, 12, pp. 783-790
Dementieva, I.S., Tereshko, V., McCrossan, Z.A., Solomaha, E., Araki, D., Xu, C., Grigorieff, N., Goldstein, S.A., Pentameric assembly of potassium channel tetramerization domain-containing protein 5 (2009) J. Mol. Biol., 387, pp. 175-191
Van Bogaert, P., Azizieh, R., Desir, J., Aeby, A., De Meirleir, L., Laes, J.F., Christiaens, F., Abramowicz, M.J., Mutation of a potassium channel-related gene in progressive myoclonic epilepsy (2007) Ann. Neurol., 61, pp. 579-586
Elks, C.E., Loos, R.J., Sharp, S.J., Langenberg, C., Ring, S.M., Timpson, N.J., Ness, A.R., Ong, K.K., Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth PLoS Med., 7, pp. e1000284
Schwenk, J., Metz, M., Zolles, G., Turecek, R., Fritzius, T., Bildl, W., Tarusawa, E., Bettler, B., Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits (2010) Nature, 465, pp. 231-235
Bartoi, T., Rigbolt, K.T., Du, D., Kohr, G., Blagoev, B., Kornau, H.C., GABAB receptor constituents revealed by tandem affinity purification from transgenic mice (2010) J. Biol. Chem., 285, pp. 20625-20633
Bayon, Y., Trinidad, A.G., de la Puerta, M.L., Del Carmen Rodriguez, M., Bogetz, J., Rojas, A., De Pereda, J.M., Alonso, A., Kctd5, a putative substrate adaptor for cullin3 ubiquitin ligases (2008) FEBS J., 275, pp. 3900-3910
Gallo, R., Zazzeroni, F., Alesse, E., Mincione, C., Borello, U., Buanne, P., D'Eugenio, R., Gulino, A., Ren: a novel, developmentally regulated gene that promotes neural cell differentiation (2002) J. Cell Biol., 158, pp. 731-740
De Smaele, E., Di Marcotullio, L., Ferretti, E., Screpanti, I., Alesse, E., Gulino, A., Chromosome 17p deletion in human medulloblastoma: a missing checkpoint in the hedgehog pathway (2004) Cell Cycle, 3, pp. 1263-1266
Ferretti, E., De Smaele, E., Di Marcotullio, L., Screpanti, I., Gulino, A., Hedgehog checkpoints in medulloblastoma: The chromosome 17p deletion paradigm (2005) Trends Mol. Med., 11, pp. 537-545
Mancarelli, M.M., Zazzeroni, F., Ciccocioppo, L., Capece, D., Po, A., Murgo, S., Di Camillo, R., Alesse, E., The tumor suppressor gene kctd11ren is regulated by sp1 and methylation and its expression is reduced in tumors (2010) Mol. Cancer, 9, p. 172
Canettieri, G., Di Marcotullio, L., Greco, A., Coni, S., Antonucci, L., Infante, P., Pietrosanti, L., Gulino, A., Histone deacetylase and cullin3-ren(kctd11) ubiquitin ligase interplay regulates hedgehog signalling through gli acetylation (2010) Nat. Cell Biol., 12, pp. 132-142
Correale, S., Pirone, L., Di Marcotullio, L., De Smaele, E., Greco, A., Mazzà, D., Moretti, M., Pedone, E.M., Molecular organization of the cullin e3 ligase adaptor kctd11 (2011) Biochimie, 93, pp. 715-724
Vuilleumier, S., Mutter, M., Synthetic peptide and template-assembled synthetic protein models of the hen egg white lysozyme 87-97 helix: importance of a protein-like framework for conformational stability in a short peptide sequence (1993) Biopolymers, 33, pp. 389-400
D'Andrea, L.D., Iaccarino, G., Fattorusso, R., Sorriento, D., Carannante, C., Capasso, D., Trimarco, B., Pedone, C., Targeting angiogenesis: structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (2005) Proc. Natl. Acad. Sci. U.S.A., 102, pp. 14215-14220
Walensky, L.D., Kung, A.L., Escher, I., Malia, T.J., Barbuto, S., Wright, R.D., Wagner, G., Korsmeyer, S.J., Activation of apoptosis in vivo by a hydrocarbon-stapled bh3 helix (2004) Science, 305, pp. 1466-1470
Stogios, P. J., Downs, G. S., Jauhal, J. J., Nandra, S. K., Prive, G. G., Sequence and structural analysis of BTB domain proteins (2005) Genome Biol., 6, pp. R8
Bardwell, V. J., Treisman, R., The POZ domain: a conserved protein-protein interaction motif (1994) Genes Dev., 8, pp. 1664-1677
Kang, M. I., Kobayashi, A., Wakabayashi, N., Kim, S. G., Yamamoto, M., Scaffolding of keap1 to the actin cytoskeleton controls the function of nrf2 as key regulator of cytoprotective phase 2 genes (2004) Proc. Natl. Acad. Sci. U. S. A., 101, pp. 2046-2051
Minor, D. L., Lin, Y. F., Mobley, B. C., Avelar, A., Jan, Y. N., Jan, L. Y., Berger, J. M., The polar t1 interface is linked to conformational changes that open the voltage-gated potassium channel (2000) Cell, 102, pp. 657-670
Dementieva, I. S., Tereshko, V., McCrossan, Z. A., Solomaha, E., Araki, D., Xu, C., Grigorieff, N., Goldstein, S. A., Pentameric assembly of potassium channel tetramerization domain-containing protein 5 (2009) J. Mol. Biol., 387, pp. 175-191
Elks, C. E., Loos, R. J., Sharp, S. J., Langenberg, C., Ring, S. M., Timpson, N. J., Ness, A. R., Ong, K. K., Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth PLoS Med., 7, pp. e1000284
Mancarelli, M. M., Zazzeroni, F., Ciccocioppo, L., Capece, D., Po, A., Murgo, S., Di Camillo, R., Alesse, E., The tumor suppressor gene kctd11ren is regulated by sp1 and methylation and its expression is reduced in tumors (2010) Mol. Cancer, 9, p. 172
D'Andrea, L. D., Iaccarino, G., Fattorusso, R., Sorriento, D., Carannante, C., Capasso, D., Trimarco, B., Pedone, C., Targeting angiogenesis: structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (2005) Proc. Natl. Acad. Sci. U. S. A., 102, pp. 14215-14220
Walensky, L. D., Kung, A. L., Escher, I., Malia, T. J., Barbuto, S., Wright, R. D., Wagner, G., Korsmeyer, S. J., Activation of apoptosis in vivo by a hydrocarbon-stapled bh3 helix (2004) Science, 305, pp. 1466-1470
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 373-376.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 1.799, 5-year impact factor Impact factor a 5 anni: 1.714
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79953802203&partnerID=40&md5=d9027cbb3a788f1ae3f940b9c088ce43
Keywords Parole chiave: Poz Btb Domains, Protein-Protein Recognition, Structure-Function Relationships, Ubiquitination, Cullin, Protein Kctd, Unclassified Drug, Article, Molecular Model, Peptide Analysis, Peptide Synthesis, Priority Journal, Protein Binding, Protein Domain, Protein Protein Interaction, Circular Dichroism, Cullin Proteins, Enzyme-Linked Immunosorbent Assay, Humans, Potassium Channels, Protein Structure, Secondary, Poxviridae,
Affiliations Affiliazioni:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR, 80134 Napoli, Italy
Department of Biological Sciences, Federico II University, 80134 Napoli, Italy
References Riferimenti:
Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K., Prive, G.G., Sequence and structural analysis of BTB domain proteins (2005) Genome Biol., 6, pp. R8
Zollman, S., Godt, D., Prive, G.G., Couderc, J.L., Laski, F.A., The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in drosophila (1994) Proc. Natl. Acad. Sci. U.S.A., 91, pp. 10717-10721
Bardwell, V.J., Treisman, R., The POZ domain: a conserved protein-protein interaction motif (1994) Genes Dev., 8, pp. 1664-1677
Melnick, A., Ahmad, K.F., Arai, S., Polinger, A., Ball, H., Borden, K.L., Carlile, G.W., Licht, J.D., In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions (2000) Mol. Cell Biol., 20, pp. 6550-6567
Kang, M.I., Kobayashi, A., Wakabayashi, N., Kim, S.G., Yamamoto, M., Scaffolding of keap1 to the actin cytoskeleton controls the function of nrf2 as key regulator of cytoprotective phase 2 genes (2004) Proc. Natl. Acad. Sci. U.S.A., 101, pp. 2046-2051
Minor, D.L., Lin, Y.F., Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y., Berger, J.M., The polar t1 interface is linked to conformational changes that open the voltage-gated potassium channel (2000) Cell, 102, pp. 657-670
Pintard, L., Willis, J.H., Willems, A., Johnson, J.L., Srayko, M., Kurz, T., Glaser, S., Peter, M., The BTB protein mel-26 is a substrate-specific adaptor of the cul-3 ubiquitin-ligase (2003) Nature, 425, pp. 311-316
Furukawa, M., He, Y.J., Borchers, C., Xiong, Y., Targeting of protein ubiquitination by BTB-cullin 3-roc1 ubiquitin ligases (2003) Nat. Cell Biol., 5, pp. 1001-1007
Geyer, R., Wee, S., Anderson, S., Yates, J., Wolf, D.A., BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases (2003) Mol. Cell, 12, pp. 783-790
Dementieva, I.S., Tereshko, V., McCrossan, Z.A., Solomaha, E., Araki, D., Xu, C., Grigorieff, N., Goldstein, S.A., Pentameric assembly of potassium channel tetramerization domain-containing protein 5 (2009) J. Mol. Biol., 387, pp. 175-191
Van Bogaert, P., Azizieh, R., Desir, J., Aeby, A., De Meirleir, L., Laes, J.F., Christiaens, F., Abramowicz, M.J., Mutation of a potassium channel-related gene in progressive myoclonic epilepsy (2007) Ann. Neurol., 61, pp. 579-586
Elks, C.E., Loos, R.J., Sharp, S.J., Langenberg, C., Ring, S.M., Timpson, N.J., Ness, A.R., Ong, K.K., Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth PLoS Med., 7, pp. e1000284
Schwenk, J., Metz, M., Zolles, G., Turecek, R., Fritzius, T., Bildl, W., Tarusawa, E., Bettler, B., Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits (2010) Nature, 465, pp. 231-235
Bartoi, T., Rigbolt, K.T., Du, D., Kohr, G., Blagoev, B., Kornau, H.C., GABAB receptor constituents revealed by tandem affinity purification from transgenic mice (2010) J. Biol. Chem., 285, pp. 20625-20633
Bayon, Y., Trinidad, A.G., de la Puerta, M.L., Del Carmen Rodriguez, M., Bogetz, J., Rojas, A., De Pereda, J.M., Alonso, A., Kctd5, a putative substrate adaptor for cullin3 ubiquitin ligases (2008) FEBS J., 275, pp. 3900-3910
Gallo, R., Zazzeroni, F., Alesse, E., Mincione, C., Borello, U., Buanne, P., D'Eugenio, R., Gulino, A., Ren: a novel, developmentally regulated gene that promotes neural cell differentiation (2002) J. Cell Biol., 158, pp. 731-740
De Smaele, E., Di Marcotullio, L., Ferretti, E., Screpanti, I., Alesse, E., Gulino, A., Chromosome 17p deletion in human medulloblastoma: a missing checkpoint in the hedgehog pathway (2004) Cell Cycle, 3, pp. 1263-1266
Ferretti, E., De Smaele, E., Di Marcotullio, L., Screpanti, I., Gulino, A., Hedgehog checkpoints in medulloblastoma: The chromosome 17p deletion paradigm (2005) Trends Mol. Med., 11, pp. 537-545
Mancarelli, M.M., Zazzeroni, F., Ciccocioppo, L., Capece, D., Po, A., Murgo, S., Di Camillo, R., Alesse, E., The tumor suppressor gene kctd11ren is regulated by sp1 and methylation and its expression is reduced in tumors (2010) Mol. Cancer, 9, p. 172
Canettieri, G., Di Marcotullio, L., Greco, A., Coni, S., Antonucci, L., Infante, P., Pietrosanti, L., Gulino, A., Histone deacetylase and cullin3-ren(kctd11) ubiquitin ligase interplay regulates hedgehog signalling through gli acetylation (2010) Nat. Cell Biol., 12, pp. 132-142
Correale, S., Pirone, L., Di Marcotullio, L., De Smaele, E., Greco, A., Mazzà, D., Moretti, M., Pedone, E.M., Molecular organization of the cullin e3 ligase adaptor kctd11 (2011) Biochimie, 93, pp. 715-724
Vuilleumier, S., Mutter, M., Synthetic peptide and template-assembled synthetic protein models of the hen egg white lysozyme 87-97 helix: importance of a protein-like framework for conformational stability in a short peptide sequence (1993) Biopolymers, 33, pp. 389-400
D'Andrea, L.D., Iaccarino, G., Fattorusso, R., Sorriento, D., Carannante, C., Capasso, D., Trimarco, B., Pedone, C., Targeting angiogenesis: structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (2005) Proc. Natl. Acad. Sci. U.S.A., 102, pp. 14215-14220
Walensky, L.D., Kung, A.L., Escher, I., Malia, T.J., Barbuto, S., Wright, R.D., Wagner, G., Korsmeyer, S.J., Activation of apoptosis in vivo by a hydrocarbon-stapled bh3 helix (2004) Science, 305, pp. 1466-1470
Stogios, P. J., Downs, G. S., Jauhal, J. J., Nandra, S. K., Prive, G. G., Sequence and structural analysis of BTB domain proteins (2005) Genome Biol., 6, pp. R8
Bardwell, V. J., Treisman, R., The POZ domain: a conserved protein-protein interaction motif (1994) Genes Dev., 8, pp. 1664-1677
Kang, M. I., Kobayashi, A., Wakabayashi, N., Kim, S. G., Yamamoto, M., Scaffolding of keap1 to the actin cytoskeleton controls the function of nrf2 as key regulator of cytoprotective phase 2 genes (2004) Proc. Natl. Acad. Sci. U. S. A., 101, pp. 2046-2051
Minor, D. L., Lin, Y. F., Mobley, B. C., Avelar, A., Jan, Y. N., Jan, L. Y., Berger, J. M., The polar t1 interface is linked to conformational changes that open the voltage-gated potassium channel (2000) Cell, 102, pp. 657-670
Dementieva, I. S., Tereshko, V., McCrossan, Z. A., Solomaha, E., Araki, D., Xu, C., Grigorieff, N., Goldstein, S. A., Pentameric assembly of potassium channel tetramerization domain-containing protein 5 (2009) J. Mol. Biol., 387, pp. 175-191
Elks, C. E., Loos, R. J., Sharp, S. J., Langenberg, C., Ring, S. M., Timpson, N. J., Ness, A. R., Ong, K. K., Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth PLoS Med., 7, pp. e1000284
Mancarelli, M. M., Zazzeroni, F., Ciccocioppo, L., Capece, D., Po, A., Murgo, S., Di Camillo, R., Alesse, E., The tumor suppressor gene kctd11ren is regulated by sp1 and methylation and its expression is reduced in tumors (2010) Mol. Cancer, 9, p. 172
D'Andrea, L. D., Iaccarino, G., Fattorusso, R., Sorriento, D., Carannante, C., Capasso, D., Trimarco, B., Pedone, C., Targeting angiogenesis: structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (2005) Proc. Natl. Acad. Sci. U. S. A., 102, pp. 14215-14220
Walensky, L. D., Kung, A. L., Escher, I., Malia, T. J., Barbuto, S., Wright, R. D., Wagner, G., Korsmeyer, S. J., Activation of apoptosis in vivo by a hydrocarbon-stapled bh3 helix (2004) Science, 305, pp. 1466-1470
Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD - cullin 3 recognition
Pox virus Zinc/Bric-a-brac, Tramtrack and Broad (POZ/BTB) is a widespread domain detected in proteins involved in a variety of biological processes. Human genome analyses have unveiled the presence of POZ/BTB domain in a class of proteins (KCTD) whose role as important players in crucial biological processes is emerging. The development of new molecular entities able to interact with these proteins and to modulate their activity is a field of relevant interest. By using molecular modeling and literature mutagenesis analyses, we here designed and characterized a peptide that is able to interact with submicromolar affinities with two different members (KCTD11 and KCTD5) of this family. This finding suggests that the tetrameric KCTD11 and the pentameric KCTD5 are endowed with a similar cavity at the subunit-subunit interface deputed to the Cul3 binding, despite their different oligomeric states. Copyright (C) 2011 European Peptide Society and John Wiley & Sons, Ltd.
Pox virus Zinc/Bric-a-brac, Tramtrack and Broad (POZ/BTB) is a widespread domain detected in proteins involved in a variety of biological processes. Human genome analyses have unveiled the presence of POZ/BTB domain in a class of proteins (KCTD) whose role as important players in crucial biological processes is emerging. The development of new molecular entities able to interact with these proteins and to modulate their activity is a field of relevant interest. By using molecular modeling and literature mutagenesis analyses, we here designed and characterized a peptide that is able to interact with submicromolar affinities with two different members (KCTD11 and KCTD5) of this family. This finding suggests that the tetrameric KCTD11 and the pentameric KCTD5 are endowed with a similar cavity at the subunit-subunit interface deputed to the Cul3 binding, despite their different oligomeric states. Copyright (C) 2011 European Peptide Society and John Wiley & Sons, Ltd.
Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD - cullin 3 recognition
Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD - cullin 3 recognition
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Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (398 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
Dettagli Esporta in BibTeX Esporta in EndNote
Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
* Molecular organization of the cullin E3 ligase adaptor KCTD11 (387 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
Dettagli Esporta in BibTeX Esporta in EndNote
Severino V, Chambery A, Di Maro A, Marasco D, Ruggiero A, Berisio R, Giansanti F, Ippoliti R, Parente A
* The role of the glycan moiety on the structure-function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves (359 visite)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(3): 570-579.
Impact Factor: 3.825
Dettagli Esporta in BibTeX Esporta in EndNote
Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (296 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
Dettagli Esporta in BibTeX Esporta in EndNote
17 Records (16 escludendo Abstract e Conferenze).
Impact factor totale: 108.044 (104.81 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 108.923 (105.221 escludendo Abstract e Conferenze).
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Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (428 visite)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
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Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (356 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
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Barone D, Balasco N, Vitagliano L
* KCTD5 is endowed with large, functionally relevant, interdomain motions (209 visite)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2016 Aug; 34(8): 1725-1735.
Impact Factor: 3.123
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Smaldone G, Pirone L, Balasco N, Di Gaetano S, Pedone E, Vitagliano L
* Cullin 3 recognition is not a universal property among KCTD proteins (457 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 May 14; 10(5): e0126808-e0126808.
Impact Factor: 3.057
Dettagli Esporta in BibTeX Esporta in EndNote
De Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazza D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L
* Cullin3 - BTB interface: A novel target for stapled peptides (508 visite) (PDF 33 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Apr 7; 10(4): e0121149-e0121149.
Impact Factor: 3.057
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Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (389 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
Dettagli Esporta in BibTeX Esporta in EndNote
Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (328 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Jul; 1844(7): 1289-1298.
Impact Factor: 4.882
Dettagli Esporta in BibTeX Esporta in EndNote
Arena G, Bellia F, Frasca G, Grasso G, Lanza V, Rizzarelli E, Tabbì G, Zito V, Milardi D
* Inorganic stressors of ubiquitin (336 visite) (PDF 194 visite)
Inorg Chem (ISSN: 1520-510x, 1520-510xelectronic, 0020-1669linking), 2013 Sep 19; 52(16): 9567-9573.
Impact Factor: 4.794
Dettagli Esporta in BibTeX Esporta in EndNote
Lignitto L, Arcella A, Sepe M, Rinaldi L, Delle Donne R, Gallo A, Stefan E, Bachmann VA, Oliva MA, Tiziana Storlazzi C, L'Abbate A, Brunetti A, Gargiulo S, Gramanzini M, Insabato L, Garbi C, Gottesman ME, Feliciello A
* Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth (400 visite)
Nat Commun (ISSN: 2041-1723, 2041-1723electronic, 2041-1723linking), 2013 May; 4: 100-105.
Impact Factor: 10.742
Dettagli Esporta in BibTeX Esporta in EndNote
Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (410 visite)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2013; 452(3): 545-557.
Impact Factor: 4.779
Dettagli Esporta in BibTeX Esporta in EndNote
Pirone L, Esposito C, Correale S, Graziano G, Di Gaetano S, Vitagliano L, Pedone E
* Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization (435 visite)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: 162674-162674.
Impact Factor: 1.579
Dettagli Esporta in BibTeX Esporta in EndNote
Riccio A, Cubellis MV
* Gain of function in CDKN1C (479 visite)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (2356 visite)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
Dettagli Esporta in BibTeX Esporta in EndNote
Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (398 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
Dettagli Esporta in BibTeX Esporta in EndNote
Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
* Molecular organization of the cullin E3 ligase adaptor KCTD11 (387 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
Dettagli Esporta in BibTeX Esporta in EndNote
Severino V, Chambery A, Di Maro A, Marasco D, Ruggiero A, Berisio R, Giansanti F, Ippoliti R, Parente A
* The role of the glycan moiety on the structure-function relationships of PD-L1, type 1 ribosome-inactivating protein from P. dioica leaves (359 visite)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(3): 570-579.
Impact Factor: 3.825
Dettagli Esporta in BibTeX Esporta in EndNote
Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (296 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
Dettagli Esporta in BibTeX Esporta in EndNote
17 Records (16 escludendo Abstract e Conferenze).
Impact factor totale: 108.044 (104.81 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 108.923 (105.221 escludendo Abstract e Conferenze).
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