Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (417 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.692, 5-year impact factor: 3.983
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0029796805&partnerID=40&md5=921dd53707d932959a418559d33e6f29
Keywords: Alzheimer, S Disease, Benzodiazepine Receptors, Single-Photon Emission Tomography, 4 Aminobutyric Acid A Receptor, Iodine 123, Iomazenil, Tracer, Adult, Aged, Alzheimer Disease, Article, Blood Flow, Brain Cell, Brain Cortex, Case Report, Clinical Trial, Controlled Clinical Trial, Controlled Study, Female, Human, Mental Deterioration, Normal Human, Occipital Cortex, Parietal Lobe, Single Photon Emission Computer Tomography, Synapse, Temporal Cortex, Tissue Distribution, Case-Control Studies, Cerebral Cortex, Flumazenil, Iodine Radioisotopes, Middle Aged, Pilot Projects, Gaba-A, Emission-Computed,
Affiliations:
Department of Diagnostic Imaging, University of Naples Federico II, Nucl. Med. Ctr. Natl. Res. Cncl., Naples, Italy
Dept. of Clin. and Exp. Medicine, University of Naples Federico II, Naples, Italy
Dept. of Nucl. Med./Clin. Physiology, Bispebjerg Hospital, Copenhagen, Denmark
Univ. Studi di Napoli Federico II, Facolta' di Medicina e Chirurgia, Dept. of Clin. and Exp. Medicine, Via S. Pansini 5, I-80131 Napoli, Italy
References:
Nordberg, A., Neuroreceptor changes in Alzheimer disease (1992) Cerebrovasc Brain Metab Rev, 4, pp. 303-32
Greenamyre, J.T., Maragos, F., Neurotransmitter receptors in Alzheimer disease (1993) Cerebrovasc Brain Metab Rev, 5, pp. 61-94
Oslen, R.W., The GABA postsynaptic membrane receptor ionophore complex (1981) Mol Cell Biochem, 39, pp. 261-279
Hunkeler, W., Möhler, H., Pieri, L., Selective antagonist of benzodiazepines (1981) Nature, 290, pp. 514-516
Shinotoh, H., Yamasaki, T., Inoue, O., Itoh, T., Suzuki, K., Hashimoto, K., Tateno, Y., Ikeria, H., Visualization of specific binding sites of benzodiazepine in human brain (1986) J Nucl Med, 27, pp. 1593-1599
Beer, H.F., Blauentein, P.A., Hasler, P.H., Delaloye, B., Riccabona, G., Bangerl, I., Hunkeler, W., Schubiger, P.A., In vivo and in vitro evaluation of iodine 123-RO16-0154: A new imaging agent for SPECT investigations of benzodiazepine receptors (1990) J Nucl Med, 31, pp. 1007-1014
Videboek, C., Friberg, L., Holm, S., Wammen, S., Foged, C., Andersen, J.V., Dalgaard, L., Lassen, N.A., Benzodiazepine receptor equilibrium constants for flumazenil and medazolam determined in humans with the single photon emission computer tomography trace (123-I)iomazenil (1993) Eur J Pharmacol, 249, pp. 43-51
Abi-Dargham, A., Laruelle, M., Seibyl, J., Rattner, Z., Baldwin, R.M., Zoghbi, S.S., Zea-Ponce, Y., Innis, R.B., SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: Kinetic and equilibrium paradigms (1994) J Nucl Med, 35, pp. 228-238
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., Stadlan, E.M., Clinical diagnosis of Alzheimer's disease report of the NINCDS-ADRDA work group (1984) Neurology, 34, pp. 939-944
Laurell, M., Van Dyck, C., Abi-Dargham, A., Zea-Ponche, Y., Zoghbai, S., Charney, D., Baldwin, R., Innies, R., Compartmental modeling of iodine-123 iodo-benzofuran binding to dopamine D2 receptors in healthy subjects (1994) J Nucl Med, 35, pp. 743-754
Onishi, Y., Yonekura, Y., Mukai, T., Nishizawa, S., Tanaka, F., Okazawa, H., Ishizu, K., Konishi, J., Simple quantification of benzodiazepine receptor binding and ligand transport using iodine-123-iomazenil and two SPECT scans (1995) J Nucl Med, 36, pp. 1201-1210
Iida, H., Itoh, H., Bloomfield, P., Masahiro, M., Shuichi, H., Matsutaro, M., Atsushi, I., Kazuo, U., A method to quantitate cerebral blood flow using a rotating gamma camera and iodine-123 iodamphetamine with one blood sample (1994) Eur J Nucl Med, 21, pp. 1072-1084
Odano, I., Takahashi, N., Ohkubo, M., Yonekura, Y., SPECT measurement of benzodiazepine receptors in patients with Parkinson's disease with iodine-123 labeled iomazenil (1995) J Nucl Med, 36, pp. 241P
De Kosky, S.T., Bass, N.H., Biochemistry of senile dementia (1985) Handbook of Neurochemistry, pp. 617-649. , Lajtha A, ed. New York: Plenum Press
Davies, C.A., Mann, D.M., Sumpter, P.Q., Yates, P.O., A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease (1987) J Neurol Sci, 78, pp. 151-164
Schell, S.W., De Kosky, S.T., Price, D.A., Quantitative assessment of cortical synaptic density in Alzheimer's disease (1990) Neurobiol Aging, 11, pp. 29-37
Masliah, E., Terry, R.D., De Teresa, R.M., Hansen, L.A., Immunohistochemical quantification of the synapse related protein synaptophysin in Alzheimer's disease (1989) Neurosci Lett, 103, pp. 234-239
Hamos, J.E., De Gennaro, L.J., Drachman, D.A., Synaptic loss in Alzheimer's disease and other dementias (1989) Neurology, 39, pp. 355-361
Terry, R.D., Masliah, E., Salmon, D.P., Butters, N., De Teresa, R., Hill, R., Hansen, L.A., Katzman, R., Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment (1991) Ann Neurol, 30, pp. 572-580
Kanno, I., Lassen, N.A., Two methods for calculation of regional cerebral blood flow from emission computed tomography of inert gas concentrations (1979) J Comput Assist Tomogr, 3, pp. 71-76
Rapoport, S.I., Positron emission tomography in Alzheimer's disease in relation to pathogenesis: A critical review (1991) Cerebrovasc Brain Metab Rev, 3, pp. 297-335
Waldemar, G., Functional brain imaging with SPECT in normal aging and dementia (1995) Cerebrovasc Brain Metab Rev, 7, pp. 89-130
Weinberger, D.R., Jones, D., Reba, R.C., Mann, U., Coppola, R., Gibson, R., Gorey, J., Chase, T.N., A comparison of FDG PET and IQNB SPECT in normal subjects and in patients with dementia (1992) J Neuropyschiatry Clin Neurosci, 4, pp. 239-248
Wyper, D.J., Brown, D., Patterson, J., Owens, J., Hunter, R., Teasdale, E., McCulloch, J., Deficits in iodine-labelled 3-quinuclidinyl benzilate binding in relation to cerebral blood flow in patients with Alzheimer's disease (1993) Eur J Nucl Med, 20, pp. 379-386
Greenamyre, J. T., Maragos, F., Neurotransmitter receptors in Alzheimer disease (1993) Cerebrovasc Brain Metab Rev, 5, pp. 61-94
Oslen, R. W., The GABA postsynaptic membrane receptor ionophore complex (1981) Mol Cell Biochem, 39, pp. 261-279
Hunkeler, W., M hler, H., Pieri, L., Selective antagonist of benzodiazepines (1981) Nature, 290, pp. 514-516
Beer, H. F., Blauentein, P. A., Hasler, P. H., Delaloye, B., Riccabona, G., Bangerl, I., Hunkeler, W., Schubiger, P. A., In vivo and in vitro evaluation of iodine 123-RO16-0154: A new imaging agent for SPECT investigations of benzodiazepine receptors (1990) J Nucl Med, 31, pp. 1007-1014
De Kosky, S. T., Bass, N. H., Biochemistry of senile dementia (1985) Handbook of Neurochemistry, pp. 617-649. , Lajtha A, ed. New York: Plenum Press
Davies, C. A., Mann, D. M., Sumpter, P. Q., Yates, P. O., A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease (1987) J Neurol Sci, 78, pp. 151-164
Schell, S. W., De Kosky, S. T., Price, D. A., Quantitative assessment of cortical synaptic density in Alzheimer's disease (1990) Neurobiol Aging, 11, pp. 29-37
Hamos, J. E., De Gennaro, L. J., Drachman, D. A., Synaptic loss in Alzheimer's disease and other dementias (1989) Neurology, 39, pp. 355-361
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., De Teresa, R., Hill, R., Hansen, L. A., Katzman, R., Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment (1991) Ann Neurol, 30, pp. 572-580
Rapoport, S. I., Positron emission tomography in Alzheimer's disease in relation to pathogenesis: A critical review (1991) Cerebrovasc Brain Metab Rev, 3, pp. 297-335
Weinberger, D. R., Jones, D., Reba, R. C., Mann, U., Coppola, R., Gibson, R., Gorey, J., Chase, T. N., A comparison of FDG PET and IQNB SPECT in normal subjects and in patients with dementia (1992) J Neuropyschiatry Clin Neurosci, 4, pp. 239-248
Wyper, D. J., Brown, D., Patterson, J., Owens, J., Hunter, R., Teasdale, E., McCulloch, J., Deficits in iodine-labelled 3-quinuclidinyl benzilate binding in relation to cerebral blood flow in patients with Alzheimer's disease (1993) Eur J Nucl Med, 20, pp. 379-386
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.692, 5-year impact factor: 3.983
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0029796805&partnerID=40&md5=921dd53707d932959a418559d33e6f29
Keywords: Alzheimer, S Disease, Benzodiazepine Receptors, Single-Photon Emission Tomography, 4 Aminobutyric Acid A Receptor, Iodine 123, Iomazenil, Tracer, Adult, Aged, Alzheimer Disease, Article, Blood Flow, Brain Cell, Brain Cortex, Case Report, Clinical Trial, Controlled Clinical Trial, Controlled Study, Female, Human, Mental Deterioration, Normal Human, Occipital Cortex, Parietal Lobe, Single Photon Emission Computer Tomography, Synapse, Temporal Cortex, Tissue Distribution, Case-Control Studies, Cerebral Cortex, Flumazenil, Iodine Radioisotopes, Middle Aged, Pilot Projects, Gaba-A, Emission-Computed,
Affiliations:
Department of Diagnostic Imaging, University of Naples Federico II, Nucl. Med. Ctr. Natl. Res. Cncl., Naples, Italy
Dept. of Clin. and Exp. Medicine, University of Naples Federico II, Naples, Italy
Dept. of Nucl. Med./Clin. Physiology, Bispebjerg Hospital, Copenhagen, Denmark
Univ. Studi di Napoli Federico II, Facolta' di Medicina e Chirurgia, Dept. of Clin. and Exp. Medicine, Via S. Pansini 5, I-80131 Napoli, Italy
References:
Nordberg, A., Neuroreceptor changes in Alzheimer disease (1992) Cerebrovasc Brain Metab Rev, 4, pp. 303-32
Greenamyre, J.T., Maragos, F., Neurotransmitter receptors in Alzheimer disease (1993) Cerebrovasc Brain Metab Rev, 5, pp. 61-94
Oslen, R.W., The GABA postsynaptic membrane receptor ionophore complex (1981) Mol Cell Biochem, 39, pp. 261-279
Hunkeler, W., Möhler, H., Pieri, L., Selective antagonist of benzodiazepines (1981) Nature, 290, pp. 514-516
Shinotoh, H., Yamasaki, T., Inoue, O., Itoh, T., Suzuki, K., Hashimoto, K., Tateno, Y., Ikeria, H., Visualization of specific binding sites of benzodiazepine in human brain (1986) J Nucl Med, 27, pp. 1593-1599
Beer, H.F., Blauentein, P.A., Hasler, P.H., Delaloye, B., Riccabona, G., Bangerl, I., Hunkeler, W., Schubiger, P.A., In vivo and in vitro evaluation of iodine 123-RO16-0154: A new imaging agent for SPECT investigations of benzodiazepine receptors (1990) J Nucl Med, 31, pp. 1007-1014
Videboek, C., Friberg, L., Holm, S., Wammen, S., Foged, C., Andersen, J.V., Dalgaard, L., Lassen, N.A., Benzodiazepine receptor equilibrium constants for flumazenil and medazolam determined in humans with the single photon emission computer tomography trace (123-I)iomazenil (1993) Eur J Pharmacol, 249, pp. 43-51
Abi-Dargham, A., Laruelle, M., Seibyl, J., Rattner, Z., Baldwin, R.M., Zoghbi, S.S., Zea-Ponce, Y., Innis, R.B., SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: Kinetic and equilibrium paradigms (1994) J Nucl Med, 35, pp. 228-238
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., Stadlan, E.M., Clinical diagnosis of Alzheimer's disease report of the NINCDS-ADRDA work group (1984) Neurology, 34, pp. 939-944
Laurell, M., Van Dyck, C., Abi-Dargham, A., Zea-Ponche, Y., Zoghbai, S., Charney, D., Baldwin, R., Innies, R., Compartmental modeling of iodine-123 iodo-benzofuran binding to dopamine D2 receptors in healthy subjects (1994) J Nucl Med, 35, pp. 743-754
Onishi, Y., Yonekura, Y., Mukai, T., Nishizawa, S., Tanaka, F., Okazawa, H., Ishizu, K., Konishi, J., Simple quantification of benzodiazepine receptor binding and ligand transport using iodine-123-iomazenil and two SPECT scans (1995) J Nucl Med, 36, pp. 1201-1210
Iida, H., Itoh, H., Bloomfield, P., Masahiro, M., Shuichi, H., Matsutaro, M., Atsushi, I., Kazuo, U., A method to quantitate cerebral blood flow using a rotating gamma camera and iodine-123 iodamphetamine with one blood sample (1994) Eur J Nucl Med, 21, pp. 1072-1084
Odano, I., Takahashi, N., Ohkubo, M., Yonekura, Y., SPECT measurement of benzodiazepine receptors in patients with Parkinson's disease with iodine-123 labeled iomazenil (1995) J Nucl Med, 36, pp. 241P
De Kosky, S.T., Bass, N.H., Biochemistry of senile dementia (1985) Handbook of Neurochemistry, pp. 617-649. , Lajtha A, ed. New York: Plenum Press
Davies, C.A., Mann, D.M., Sumpter, P.Q., Yates, P.O., A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease (1987) J Neurol Sci, 78, pp. 151-164
Schell, S.W., De Kosky, S.T., Price, D.A., Quantitative assessment of cortical synaptic density in Alzheimer's disease (1990) Neurobiol Aging, 11, pp. 29-37
Masliah, E., Terry, R.D., De Teresa, R.M., Hansen, L.A., Immunohistochemical quantification of the synapse related protein synaptophysin in Alzheimer's disease (1989) Neurosci Lett, 103, pp. 234-239
Hamos, J.E., De Gennaro, L.J., Drachman, D.A., Synaptic loss in Alzheimer's disease and other dementias (1989) Neurology, 39, pp. 355-361
Terry, R.D., Masliah, E., Salmon, D.P., Butters, N., De Teresa, R., Hill, R., Hansen, L.A., Katzman, R., Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment (1991) Ann Neurol, 30, pp. 572-580
Kanno, I., Lassen, N.A., Two methods for calculation of regional cerebral blood flow from emission computed tomography of inert gas concentrations (1979) J Comput Assist Tomogr, 3, pp. 71-76
Rapoport, S.I., Positron emission tomography in Alzheimer's disease in relation to pathogenesis: A critical review (1991) Cerebrovasc Brain Metab Rev, 3, pp. 297-335
Waldemar, G., Functional brain imaging with SPECT in normal aging and dementia (1995) Cerebrovasc Brain Metab Rev, 7, pp. 89-130
Weinberger, D.R., Jones, D., Reba, R.C., Mann, U., Coppola, R., Gibson, R., Gorey, J., Chase, T.N., A comparison of FDG PET and IQNB SPECT in normal subjects and in patients with dementia (1992) J Neuropyschiatry Clin Neurosci, 4, pp. 239-248
Wyper, D.J., Brown, D., Patterson, J., Owens, J., Hunter, R., Teasdale, E., McCulloch, J., Deficits in iodine-labelled 3-quinuclidinyl benzilate binding in relation to cerebral blood flow in patients with Alzheimer's disease (1993) Eur J Nucl Med, 20, pp. 379-386
Greenamyre, J. T., Maragos, F., Neurotransmitter receptors in Alzheimer disease (1993) Cerebrovasc Brain Metab Rev, 5, pp. 61-94
Oslen, R. W., The GABA postsynaptic membrane receptor ionophore complex (1981) Mol Cell Biochem, 39, pp. 261-279
Hunkeler, W., M hler, H., Pieri, L., Selective antagonist of benzodiazepines (1981) Nature, 290, pp. 514-516
Beer, H. F., Blauentein, P. A., Hasler, P. H., Delaloye, B., Riccabona, G., Bangerl, I., Hunkeler, W., Schubiger, P. A., In vivo and in vitro evaluation of iodine 123-RO16-0154: A new imaging agent for SPECT investigations of benzodiazepine receptors (1990) J Nucl Med, 31, pp. 1007-1014
De Kosky, S. T., Bass, N. H., Biochemistry of senile dementia (1985) Handbook of Neurochemistry, pp. 617-649. , Lajtha A, ed. New York: Plenum Press
Davies, C. A., Mann, D. M., Sumpter, P. Q., Yates, P. O., A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease (1987) J Neurol Sci, 78, pp. 151-164
Schell, S. W., De Kosky, S. T., Price, D. A., Quantitative assessment of cortical synaptic density in Alzheimer's disease (1990) Neurobiol Aging, 11, pp. 29-37
Hamos, J. E., De Gennaro, L. J., Drachman, D. A., Synaptic loss in Alzheimer's disease and other dementias (1989) Neurology, 39, pp. 355-361
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., De Teresa, R., Hill, R., Hansen, L. A., Katzman, R., Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment (1991) Ann Neurol, 30, pp. 572-580
Rapoport, S. I., Positron emission tomography in Alzheimer's disease in relation to pathogenesis: A critical review (1991) Cerebrovasc Brain Metab Rev, 3, pp. 297-335
Weinberger, D. R., Jones, D., Reba, R. C., Mann, U., Coppola, R., Gibson, R., Gorey, J., Chase, T. N., A comparison of FDG PET and IQNB SPECT in normal subjects and in patients with dementia (1992) J Neuropyschiatry Clin Neurosci, 4, pp. 239-248
Wyper, D. J., Brown, D., Patterson, J., Owens, J., Hunter, R., Teasdale, E., McCulloch, J., Deficits in iodine-labelled 3-quinuclidinyl benzilate binding in relation to cerebral blood flow in patients with Alzheimer's disease (1993) Eur J Nucl Med, 20, pp. 379-386
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses
Iodine-123 labelled iomazenil (IMZ) is a specific tracer for the GABA(A) receptor, the dominant inhibitory synapse of the brain. The cerebral distribution volume (V(d)) of IMZ may be taken as a quantitative measure of these synapses in Alzheimer's disease (AD), where synaptic loss tends indiscriminately to affect all cortical neurons, albeit more so in some areas than in others. In this pilot study we measured V(d) in six patients with probable AD and in five age-matched controls using a brain-dedicated single-photon emission tomography scanner allowing all cortical levels to be sampled simultaneously. Reduced values were found in all regions except in the occipital (visual) cortex. In particular, temporal and parietal cortex V(d) was significantly (P < 0.02) reduced: temporal V(d) averaged 69 ml/ml in normals and 51 ml/ml in AD, and parietal V(d) averaged 71 ml/ml in normals and 48 ml/ml in AD, These results accord well with emission tomographic studies of blood flow or labelled glucose. This supports the idea that while only measuring a subpopulation of synapses, the IMZ method reflects synaptic loss and hence functional loss in AD. The method constitutes an in vivo version of synaptic quantitation that in histopathological studies has been shown to correlate closely with the mental deterioration in AD.
Iodine-123 labelled iomazenil (IMZ) is a specific tracer for the GABA(A) receptor, the dominant inhibitory synapse of the brain. The cerebral distribution volume (V(d)) of IMZ may be taken as a quantitative measure of these synapses in Alzheimer's disease (AD), where synaptic loss tends indiscriminately to affect all cortical neurons, albeit more so in some areas than in others. In this pilot study we measured V(d) in six patients with probable AD and in five age-matched controls using a brain-dedicated single-photon emission tomography scanner allowing all cortical levels to be sampled simultaneously. Reduced values were found in all regions except in the occipital (visual) cortex. In particular, temporal and parietal cortex V(d) was significantly (P < 0.02) reduced: temporal V(d) averaged 69 ml/ml in normals and 51 ml/ml in AD, and parietal V(d) averaged 71 ml/ml in normals and 48 ml/ml in AD, These results accord well with emission tomographic studies of blood flow or labelled glucose. This supports the idea that while only measuring a subpopulation of synapses, the IMZ method reflects synaptic loss and hence functional loss in AD. The method constitutes an in vivo version of synaptic quantitation that in histopathological studies has been shown to correlate closely with the mental deterioration in AD.
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses
| ▼ Relaxometry based MRI brain segmentation |
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses
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Allocca M, Linguanti F, Calcagni ML, Cistaro A, Gaudieri V, Guerra UP, Morbelli S, Nobili F, Pappata S, Sestini S, Volterrani D, Berti V, For The Neurology Study Group Of The Italian Association Of Nuclear M
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J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Milardi D, Pappalardo M
* Molecular dynamics: New advances in drug discovery (433 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015; 91: 1-3.
Impact Factor: 3.902
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DeRosa A, Carducci C, Carducci C, Peluso S, Lieto M, Mazzella A, Saccà F, Brescia Morra V, Pappata S, Leuzzi V, De Michele G
* Screening for dopa-responsive dystonia in patients with scans without evidence of dopaminergic deficiency (SWEDD) (467 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 0340-5354print), 2014 Nov; 261(11): 2204-2208.
Impact Factor: 3.377
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
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Neuroimage Clin (ISSN: 2213-1582, 2213-1582electronic, 2213-1582linking), 2014 Oct 24; 6: 445-454.
Impact Factor: 2.526
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Testi S, Peluso S, Fabrizi GM, Antenora A, Russo CV, Pappata S, Padovani A, Ferrarini M, Filla A
* A novel PSEN1 mutation in a patient with sporadic early-onset Alzheimer's disease and prominent cerebellar ataxia (289 views)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2014; 41(3): 709-714.
Impact Factor: 4.151
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Correale S, Esposito C, Pirone L, Vitagliano L, Di Gaetano S, Pedone E
* A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABA(B2) receptor (392 views)
Journal Of Molecular Recognition (ISSN: 0952-3499, 0952-2349), 2013 Oct; 26(10): 488-495.
Impact Factor: 2.337
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Erro R, Barone P, Vicidomini C, Picillo M, Pappata S
* Patients with Parkinson's disease and scans with (predominant) ipsilateral dopaminergic deficit (354 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2013 Sep; 260(9): 2405-2406.
Impact Factor: 3.841
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (541 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (778 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1532 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
* Metal ions affect insulin-degrading enzyme activity (494 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
Impact Factor: 3.197
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (461 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Pascual B, Prieto E, Arbizu J, Marti-climent JM, Penuelas I, Quincoces G, Zarauza R, Pappata S, Masdeu JC
* Decreased carbon-11-flumazenil binding in early Alzheimer's disease (405 views) (PDF 259 views)
Brain (ISSN: 0006-8950, 1460-2156electronic, 0006-8950linking), 2012 Sep; 135(Pt9): 2817-2825.
Impact Factor: 9.915
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (647 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (1000 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (594 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (900 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (491 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Erro R, Amboni M, Vitale C, Longo K, Rocco M, Russo C, Pappata S, Brunetti A, Barone P
* The "eye of the tiger" sign in pure akinesia with gait freezing (317 views) (PDF 222 views)
Neurol Sci (ISSN: 1590-1874, 1590-3478, 1590-1874linking), 2011 Sep; 32(4): 703-705.
Impact Factor: 1.315
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (464 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (596 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (612 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (576 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Varrone A, Halldin C
Molecular imaging of the dopamine transporter (542 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
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Pappata S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V, Iavarone A, Comerci M, Loré E, Panico M, Quarantelli M, Postiglione A, Salvatore M
* SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment (504 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.
Impact Factor: 5.036
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Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G
* Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation (1002 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806.
Impact Factor: 8.017
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Darcourt J, Booij J, Tatsch K, Varrone A, Borght TV, Kapucu OL, Nagren K, Nobili F, Walker Z, Van Laere K
* EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version (766 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Feb; 37(2): 443-450.
Impact Factor: 5.036
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Dickson JC, Tossici-bolt L, Sera T, Erlandsson K, Varrone A, Tatsch K, Hutton BF
* The impact of reconstruction method on the quantification of DaTSCAN images (430 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jan; 37(1): 23-35.
Impact Factor: 5.036
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ
* EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version (580 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2093-2102.
Impact Factor: 4.531
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Varrone A, Asenbaum S, Vander Borght T, Booij J, Nobili F, Någren K, Darcourt J, Kapucu OL, Tatsch K, Bartenstein P, Van Laere K
* EANM procedure guidelines for PET brain imaging using [18F]FDG, version (635 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2103-2110.
Impact Factor: 4.531
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1106 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (534 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
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Odano I, Halldin C, Karlsson P, Varrone A, Airaksinen AJ, Krasikova RN, Farde L
* [18F]Flumazenil binding to central benzodiazepine receptor studies by PET. - Quantitative analysis and comparisons with [11C]flumazenil (307 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2009 Apr 15; 45(3): 891-902.
Impact Factor: 5.739
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Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (358 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1402 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Varrone A, Sansone V, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT (341 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jul; 35(7): 1343-1349.
Impact Factor: 4.532
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Pappata S, Salvatore E, Postiglione A
* In vivo imaging of neurotransmission and brain receptors in dementia (813 views) (PDF 259 views)
J Neuroimaging (ISSN: 1051-2284, 1051-2284linking), 2008 Apr; 18(2): 111-124.
Impact Factor: 1.811
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Milan G, Lamenza F, Iavarone A, Galeone F, Lore E, De Falco C, Sorrentino P, Postiglione A
* Frontal Behavioural Inventory in the differential diagnosis of dementia (644 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2008; 117(4): 260-265.
Impact Factor: 2.317
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1004 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (517 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (629 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Serrano CM, Allegri RF, Caramelli P, Taragano FE, Camera L
* Mild cognitive impairment. Survey of attitudes of specialists and general physicians (618 views)
Medicina (ISSN: 0025-7680), 2007; 67(1): 19-25.
Impact Factor: 0.193
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Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (375 views)
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Impact Factor: 2.085
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Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (525 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (768 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappata S, Barone P
* Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease (4063 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2004 Dec 14; 63(11): 2097-2103.
Impact Factor: 5.973
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Covelli EM, Brunetti A, Di Lauro A, Sullo P, Mazzarella G, Tedeschi E, Belfiore G
* Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease (360 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2004 Oct; 108(4): 417-425.
Impact Factor: 1.368
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (552 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Kim KM, Varrone A, Watabe H, Shidahara M, Fujita M, Innis RB, Iida H
* Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities (282 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2003 Apr; 44(4): 512-519.
Impact Factor: 4.899
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M
* Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks (474 views) (PDF 309 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2002 Nov; 29(11): 1447-1454.
Impact Factor: 3.568
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Acampa W, Di Benedetto C, Cuocolo A
An overview of radiotracers in nuclear cardiology (382 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Nov; 7(6): 701-707.
Impact Factor: 1.854
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Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli EM, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (639 views) (PDF 272 views)
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 2000 Mar; 11(3): 260-266.
Impact Factor: 1.302
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Varrone A, Soricelli A, Postiglione A, Salvatore M
Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT (315 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1999 Sep; 24(9): 660-665.
Impact Factor: 0.253
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Alfano B, Quarantelli M, Brunetti A, Larobina M, Covelli EM, Tedeschi E, Salvatore M
Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation (602 views) (PDF 596 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1998 Mar; 39(3): 497-499.
Impact Factor: 2.962
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Postiglione A, Soricelli A, Grossi D, Romano M, Mainenti PP, Ruocco A, Fragrassi N, Chiacchio L, Milan G, De Chiara S, Brunetti A
Changes in cerebral blood flow during cognitive activation evaluated by single photon emission computed tomography in patients with Alzheimer's disease (449 views)
Alzheimer S Res (ISSN: 1356-918x), 1997 Jun; 3(3): 93-99.
Impact Factor: 0
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Postiglione A, Soricelli, Salvatore M, Lassen NA
123I-iomazenil as a clinical tool for studying neuronal loss [4] (340 views)
J Am Geriatr Soc (ISSN: 0002-8614), 1997 Apr; 45(4): 534-536.
Impact Factor: 2.806
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Soricelli A, Varrone A, Acampa W, Postiglione A, Salvatore M, Lassen N
Brain perfusion with Tc-99m HMPAO and neuronal loss with 123-iomazenil in Alzheimer disease (323 views)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 1996 Nov; 201: N/D-N/D.
Impact Factor: 4.989
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Tedeschi E, Soricelli A, Brunetti A, Romano M, Bucciero A, Iaconetta G, Alfieri A, Postiglione A, Salvatore M
Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas (379 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Nov; 23(11): 1478-1484.
Impact Factor: 2.692
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TEDESCHI E, BRUNETTI A, SORICELLI A, COVELLI E, PAONE G, ALFANO B, CASTELLI L, OREFICE G, CATALDO P, SALVATORE M
Single-photon emission tomography and magnetic resonance imaging in AIDS patients without focal neurological deficits (272 views)
Neuroradiology 1994, 1994; N/D: N/D-N/D.
Impact Factor: 0
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* Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study (7 views)
J Clin Med (ISSN: 2077-0383linking), 2021 Oct 25; 10(21): N/D-N/D.
Impact Factor: 4.963
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Coppola C, Saracino D, Oliva M, Cipriano L, Puoti G, Pappata S, Di Fede G, Catania M, Ricci M, Cimini S, Giaccone G, Bonavita S, Rossi G
* Singular cases of Alzheimer's disease disclose new and old genetic "acquaintances" (70 views)
Neurol Sci (ISSN: 1590-1874linking, 1590-3478), 2021 May; 42(5): 2021-2029.
Impact Factor: 1.447
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Marchitelli R, Aiello M, Cachia A, Quarantelli M, Cavaliere C, Postiglione A, Tedeschi G, Montella P, Milan G, Salvatore M, Salvatore E, Baron JC, Pappata S
* Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity (1294 views)
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Impact Factor: 5.835
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Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (853 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (489 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (544 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
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Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E
* Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (727 views) (PDF 197 views)
Aging Cell (ISSN: 1474-9726, 1474-9718linking), 2017 Nov 01; 17(1): N/D-N/D.
Impact Factor: 7.627
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (291 views)
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Impact Factor: 5.012
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Palmieri G, Cocca E, Gogliettino M, Valentino R, Ruvo M, Cristofano G, Angiolillo A, Balestrieri M, Rossi M, Di Costanzo A
* Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis? (350 views)
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Impact Factor: 3.476
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D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (781 views)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (527 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (806 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
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Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (424 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
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Peluso S, De Rosa A, Antenora A, Lieto M, Criscuolo C, Barbieri F, Pappata S, De Michele G
* Efficacy of dopamine agonist treatment in delayed-onset parkinsonism due to midbrain hemorrhage (255 views)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1353-8020print), 2015 Feb; 21(2): 156-158.
Impact Factor: 3.794
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Milardi D, Pappalardo M
* Molecular dynamics: New advances in drug discovery (433 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015; 91: 1-3.
Impact Factor: 3.902
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DeRosa A, Carducci C, Carducci C, Peluso S, Lieto M, Mazzella A, Saccà F, Brescia Morra V, Pappata S, Leuzzi V, De Michele G
* Screening for dopa-responsive dystonia in patients with scans without evidence of dopaminergic deficiency (SWEDD) (467 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 0340-5354print), 2014 Nov; 261(11): 2204-2208.
Impact Factor: 3.377
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
* Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting (516 views)
Neuroimage Clin (ISSN: 2213-1582, 2213-1582electronic, 2213-1582linking), 2014 Oct 24; 6: 445-454.
Impact Factor: 2.526
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Testi S, Peluso S, Fabrizi GM, Antenora A, Russo CV, Pappata S, Padovani A, Ferrarini M, Filla A
* A novel PSEN1 mutation in a patient with sporadic early-onset Alzheimer's disease and prominent cerebellar ataxia (289 views)
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Impact Factor: 4.151
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Correale S, Esposito C, Pirone L, Vitagliano L, Di Gaetano S, Pedone E
* A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABA(B2) receptor (392 views)
Journal Of Molecular Recognition (ISSN: 0952-3499, 0952-2349), 2013 Oct; 26(10): 488-495.
Impact Factor: 2.337
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Erro R, Barone P, Vicidomini C, Picillo M, Pappata S
* Patients with Parkinson's disease and scans with (predominant) ipsilateral dopaminergic deficit (354 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2013 Sep; 260(9): 2405-2406.
Impact Factor: 3.841
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (541 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (778 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1532 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
* Metal ions affect insulin-degrading enzyme activity (494 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
Impact Factor: 3.197
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (461 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Pascual B, Prieto E, Arbizu J, Marti-climent JM, Penuelas I, Quincoces G, Zarauza R, Pappata S, Masdeu JC
* Decreased carbon-11-flumazenil binding in early Alzheimer's disease (405 views) (PDF 259 views)
Brain (ISSN: 0006-8950, 1460-2156electronic, 0006-8950linking), 2012 Sep; 135(Pt9): 2817-2825.
Impact Factor: 9.915
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (647 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (1000 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (594 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (900 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (491 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Erro R, Amboni M, Vitale C, Longo K, Rocco M, Russo C, Pappata S, Brunetti A, Barone P
* The "eye of the tiger" sign in pure akinesia with gait freezing (317 views) (PDF 222 views)
Neurol Sci (ISSN: 1590-1874, 1590-3478, 1590-1874linking), 2011 Sep; 32(4): 703-705.
Impact Factor: 1.315
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (464 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (596 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (612 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (576 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Varrone A, Halldin C
Molecular imaging of the dopamine transporter (542 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
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Pappata S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V, Iavarone A, Comerci M, Loré E, Panico M, Quarantelli M, Postiglione A, Salvatore M
* SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment (504 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.
Impact Factor: 5.036
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Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G
* Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation (1002 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806.
Impact Factor: 8.017
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Darcourt J, Booij J, Tatsch K, Varrone A, Borght TV, Kapucu OL, Nagren K, Nobili F, Walker Z, Van Laere K
* EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version (766 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Feb; 37(2): 443-450.
Impact Factor: 5.036
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Dickson JC, Tossici-bolt L, Sera T, Erlandsson K, Varrone A, Tatsch K, Hutton BF
* The impact of reconstruction method on the quantification of DaTSCAN images (430 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jan; 37(1): 23-35.
Impact Factor: 5.036
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ
* EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version (580 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2093-2102.
Impact Factor: 4.531
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Varrone A, Asenbaum S, Vander Borght T, Booij J, Nobili F, Någren K, Darcourt J, Kapucu OL, Tatsch K, Bartenstein P, Van Laere K
* EANM procedure guidelines for PET brain imaging using [18F]FDG, version (635 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2103-2110.
Impact Factor: 4.531
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1106 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (534 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
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Odano I, Halldin C, Karlsson P, Varrone A, Airaksinen AJ, Krasikova RN, Farde L
* [18F]Flumazenil binding to central benzodiazepine receptor studies by PET. - Quantitative analysis and comparisons with [11C]flumazenil (307 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2009 Apr 15; 45(3): 891-902.
Impact Factor: 5.739
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Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (358 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1402 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Varrone A, Sansone V, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT (341 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jul; 35(7): 1343-1349.
Impact Factor: 4.532
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Pappata S, Salvatore E, Postiglione A
* In vivo imaging of neurotransmission and brain receptors in dementia (813 views) (PDF 259 views)
J Neuroimaging (ISSN: 1051-2284, 1051-2284linking), 2008 Apr; 18(2): 111-124.
Impact Factor: 1.811
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Milan G, Lamenza F, Iavarone A, Galeone F, Lore E, De Falco C, Sorrentino P, Postiglione A
* Frontal Behavioural Inventory in the differential diagnosis of dementia (644 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2008; 117(4): 260-265.
Impact Factor: 2.317
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1004 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (517 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (629 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Serrano CM, Allegri RF, Caramelli P, Taragano FE, Camera L
* Mild cognitive impairment. Survey of attitudes of specialists and general physicians (618 views)
Medicina (ISSN: 0025-7680), 2007; 67(1): 19-25.
Impact Factor: 0.193
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Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (375 views)
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Impact Factor: 2.085
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Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (525 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (768 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappata S, Barone P
* Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease (4063 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2004 Dec 14; 63(11): 2097-2103.
Impact Factor: 5.973
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Covelli EM, Brunetti A, Di Lauro A, Sullo P, Mazzarella G, Tedeschi E, Belfiore G
* Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease (360 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2004 Oct; 108(4): 417-425.
Impact Factor: 1.368
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (552 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Kim KM, Varrone A, Watabe H, Shidahara M, Fujita M, Innis RB, Iida H
* Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities (282 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2003 Apr; 44(4): 512-519.
Impact Factor: 4.899
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M
* Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks (474 views) (PDF 309 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2002 Nov; 29(11): 1447-1454.
Impact Factor: 3.568
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Acampa W, Di Benedetto C, Cuocolo A
An overview of radiotracers in nuclear cardiology (382 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Nov; 7(6): 701-707.
Impact Factor: 1.854
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Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli EM, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (639 views) (PDF 272 views)
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 2000 Mar; 11(3): 260-266.
Impact Factor: 1.302
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Varrone A, Soricelli A, Postiglione A, Salvatore M
Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT (315 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1999 Sep; 24(9): 660-665.
Impact Factor: 0.253
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Alfano B, Quarantelli M, Brunetti A, Larobina M, Covelli EM, Tedeschi E, Salvatore M
Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation (602 views) (PDF 596 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1998 Mar; 39(3): 497-499.
Impact Factor: 2.962
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Postiglione A, Soricelli A, Grossi D, Romano M, Mainenti PP, Ruocco A, Fragrassi N, Chiacchio L, Milan G, De Chiara S, Brunetti A
Changes in cerebral blood flow during cognitive activation evaluated by single photon emission computed tomography in patients with Alzheimer's disease (449 views)
Alzheimer S Res (ISSN: 1356-918x), 1997 Jun; 3(3): 93-99.
Impact Factor: 0
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Postiglione A, Soricelli, Salvatore M, Lassen NA
123I-iomazenil as a clinical tool for studying neuronal loss [4] (340 views)
J Am Geriatr Soc (ISSN: 0002-8614), 1997 Apr; 45(4): 534-536.
Impact Factor: 2.806
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Soricelli A, Varrone A, Acampa W, Postiglione A, Salvatore M, Lassen N
Brain perfusion with Tc-99m HMPAO and neuronal loss with 123-iomazenil in Alzheimer disease (323 views)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 1996 Nov; 201: N/D-N/D.
Impact Factor: 4.989
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Tedeschi E, Soricelli A, Brunetti A, Romano M, Bucciero A, Iaconetta G, Alfieri A, Postiglione A, Salvatore M
Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas (379 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Nov; 23(11): 1478-1484.
Impact Factor: 2.692
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TEDESCHI E, BRUNETTI A, SORICELLI A, COVELLI E, PAONE G, ALFANO B, CASTELLI L, OREFICE G, CATALDO P, SALVATORE M
Single-photon emission tomography and magnetic resonance imaging in AIDS patients without focal neurological deficits (272 views)
Neuroradiology 1994, 1994; N/D: N/D-N/D.
Impact Factor: 0
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81 Records (77 excluding Abstracts).
Total impact factor: 338.942 (325.51 excluding Abstracts).
Total 5 year impact factor: 357.261 (342.066 excluding Abstracts).
Total impact factor: 338.942 (325.51 excluding Abstracts).
Total 5 year impact factor: 357.261 (342.066 excluding Abstracts).
417 views. Last view on Saturday 25 March 2023, 20:40:43
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