Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (849 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 4.566, 5-year impact factor: 5.504
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037137615&partnerID=40&md5=38ade24ffa8485fb569d70f95d767ace
Keywords: 8 Hydroxyguanine, Bleomycin, Ferrocene, Ferrocenium Derivative, Hydroxyl Radical, Oxygen Radical, Superoxide, Unclassified Drug, Antineoplastic Activity, Aqueous Solution, Article, Cell Compartmentalization, Cell Growth, Cell Viability, Controlled Study, Cytotoxicity, Dna Damage, Dose Response, Electron Spin Resonance, Fluorescence Activated Cell Sorting, Growth Inhibition, Human, Human Cell, Oxidative Stress, Ultraviolet Spectroscopy, Antineoplastic Agents, Drug Screening Assays, Antitumor, Drug Stability, Drug Synergism, Electron Spin Resonance Spectroscopy, Ferrous Compounds, Free Radicals, Oxidation-Reduction, Spectrophotometry, Spin Trapping, Tumor Cells, Cultured, Water, Antineoplastic Agents Chemical Synthesis Chemistry Metabolism, Bleomycin Pharmacology, Ferrous Compounds Chemical Synthesis Chemistry Pharmacology, Free Radicals Metabolism, Japna, Polymers, Degradation, Polyvinyl Chloride,
Affiliations:
*** IBB - CNR ***
Ist. di Biostrutture e Bioimmagini, CNR, Sezione di Catania, viale A. Doria 6, I-95125, Catania, Italy
Dipto. di Sci./Tecnologie Avazante, Univ. Piemonte Orient. A. Avogadro, corso Borsalino 54, I-15100, Alessandria, Italy
Dipartimento di Scienze Mediche, Univ. Piemonte Orient. A. Avogadro, via Solaroli 17, I-28100, Novara, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Sezione di Catania, viale A. Doria 6, I-95125, Catania, Italy.
Dipto. di Sci. /Tecnologie Avazante, Univ. Piemonte Orient. A. Avogadro, corso Borsalino 54, I-15100, Alessandria, Italy
References:
Not available.
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 4.566, 5-year impact factor: 5.504
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037137615&partnerID=40&md5=38ade24ffa8485fb569d70f95d767ace
Keywords: 8 Hydroxyguanine, Bleomycin, Ferrocene, Ferrocenium Derivative, Hydroxyl Radical, Oxygen Radical, Superoxide, Unclassified Drug, Antineoplastic Activity, Aqueous Solution, Article, Cell Compartmentalization, Cell Growth, Cell Viability, Controlled Study, Cytotoxicity, Dna Damage, Dose Response, Electron Spin Resonance, Fluorescence Activated Cell Sorting, Growth Inhibition, Human, Human Cell, Oxidative Stress, Ultraviolet Spectroscopy, Antineoplastic Agents, Drug Screening Assays, Antitumor, Drug Stability, Drug Synergism, Electron Spin Resonance Spectroscopy, Ferrous Compounds, Free Radicals, Oxidation-Reduction, Spectrophotometry, Spin Trapping, Tumor Cells, Cultured, Water, Antineoplastic Agents Chemical Synthesis Chemistry Metabolism, Bleomycin Pharmacology, Ferrous Compounds Chemical Synthesis Chemistry Pharmacology, Free Radicals Metabolism, Japna, Polymers, Degradation, Polyvinyl Chloride,
Affiliations:
*** IBB - CNR ***
Ist. di Biostrutture e Bioimmagini, CNR, Sezione di Catania, viale A. Doria 6, I-95125, Catania, Italy
Dipto. di Sci./Tecnologie Avazante, Univ. Piemonte Orient. A. Avogadro, corso Borsalino 54, I-15100, Alessandria, Italy
Dipartimento di Scienze Mediche, Univ. Piemonte Orient. A. Avogadro, via Solaroli 17, I-28100, Novara, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Sezione di Catania, viale A. Doria 6, I-95125, Catania, Italy.
Dipto. di Sci. /Tecnologie Avazante, Univ. Piemonte Orient. A. Avogadro, corso Borsalino 54, I-15100, Alessandria, Italy
References:
Not available.
Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process
The cytotoxicity of some ferrocenium salts and the lack of activity of the corresponding ferrocenes has been already demonstrated. The cytotoxic activity in different conditions of decamethylferrocenium tetrafluoroborate (DEMFc(+)) in comparison with four other ferrocenium derivatives on MCF-7 cell line is reported. The relative stability in aqueous solutions with different buffering agents is investigated by means of UV-vis spectroscopy and correlated to the cytotoxic properties of the compounds. DEMFc(+), the most stable compound, shows the highest efficiency in inhibiting cell growth (IC(50) 35 microM, for 48 h treatment). Relaxation time measurements point out the involvement of water molecules in the degradation process. ESR results confirm the ability of ferrocenium cations to produce oxygen radical species as a consequence of their degradation in water. Oxygen-dependent formation of both hydroxyl and superoxide radicals is established by the spin-trapping technique. A direct evidence of the DEMFc(+) radical production into the viable cells is obtained by means of fluorescence-activated cell sorter (FACS) analysis that reveals a dose-dependent growth of 8-oxoguanine, the initial product of the guanine oxidation. This DNA oxidative stress justifies the cytotoxic effect of DEMFc(+). Furthermore, the cytotoxic cooperative effect of bleomycin, an iron-dependent antitumor drug, and DEMFc(+) has been tested. We have demonstrated the synergic effect between the two drugs, that is explained by the complementary oxidative damage inflicted to DNA as well as by the increasing of bleomycin activation by the iron(II/III) species available in the cell compartment from ferrocenium degradation.
The cytotoxicity of some ferrocenium salts and the lack of activity of the corresponding ferrocenes has been already demonstrated. The cytotoxic activity in different conditions of decamethylferrocenium tetrafluoroborate (DEMFc(+)) in comparison with four other ferrocenium derivatives on MCF-7 cell line is reported. The relative stability in aqueous solutions with different buffering agents is investigated by means of UV-vis spectroscopy and correlated to the cytotoxic properties of the compounds. DEMFc(+), the most stable compound, shows the highest efficiency in inhibiting cell growth (IC(50) 35 microM, for 48 h treatment). Relaxation time measurements point out the involvement of water molecules in the degradation process. ESR results confirm the ability of ferrocenium cations to produce oxygen radical species as a consequence of their degradation in water. Oxygen-dependent formation of both hydroxyl and superoxide radicals is established by the spin-trapping technique. A direct evidence of the DEMFc(+) radical production into the viable cells is obtained by means of fluorescence-activated cell sorter (FACS) analysis that reveals a dose-dependent growth of 8-oxoguanine, the initial product of the guanine oxidation. This DNA oxidative stress justifies the cytotoxic effect of DEMFc(+). Furthermore, the cytotoxic cooperative effect of bleomycin, an iron-dependent antitumor drug, and DEMFc(+) has been tested. We have demonstrated the synergic effect between the two drugs, that is explained by the complementary oxidative damage inflicted to DNA as well as by the increasing of bleomycin activation by the iron(II/III) species available in the cell compartment from ferrocenium degradation.
Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process
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Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process
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Vecchio G, Lanza V
Synthesis of Superoxide Dismutase (SOD) enzyme mimetics: A bioinorganic laboratory experiment (333 views)
Journal Of Chemical Education, 2009; 86(12): 1419-1421.
Impact Factor: 0
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (480 views)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
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Esposito L, Seydel A, Aiello R, Sorrentino G, Cendron L, Zanotti G, Zagari
* The crystal structure of the superoxide dismutase from Helicobacter pylori reveals a structured C-terminal extension (441 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Nov; 1784(11): 1601-1606.
Impact Factor: 2.233
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Bonomo RP, D'Alessandro F, Grasso G, Impellizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
* Carcinine-beta-cyclodextrin derivatives as scavenger entities of (OH) radicals and SOD-like properties of their copper(II) complexes (291 views)
Inorg Chim Acta (ISSN: 0020-1693), 2008 May 5; 361(6): 1705-1714.
Impact Factor: 1.94
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Merlino A, Russo Krauss I, Castellano I, De Vendittis E, Vergara A, Sica F
* Crystallization and preliminary x-ray diffraction studies of a psychrophilic iron superoxide dismutase from Pseudoalteromonas haloplanktis (390 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2008; 15(4): 415-418.
Impact Factor: 1.281
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (528 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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D'Agata R, Grasso G, Iacono G, Spoto G, Vecchio G
* Lectin recognition of a new SOD mimic bioconjugate studied with surface plasmon resonance imaging (312 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Feb 21; 4(4): 610-612.
Impact Factor: 2.874
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (733 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Pedone E, Bartolucci S, Fiorentino G
* Sensing and adapting to environmental stress: The Archaeal tactic (364 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2004 Sep 1; 9: 2909-2926.
Impact Factor: 3.226
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Puglisi A, Tabbì G, Vecchio G
* Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity (417 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jun; 98(6): 969-976.
Impact Factor: 2.225
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Bonomo RP, Impellizzeri G, La Mendola D, Maccarone G, Pappalardo G, Santoro A, Tabbì G, Vecchio G, Rizzarelli E
* Functional Mimics Of Cu, Zn-Superoxide Dismutase Enzymes, In Metal-Ligand Interactions In Nano-, Micro-, And Macro-Systems In Complex Environments (244 views)
In Complex Environmentsmetal Ligand Interactions (ISSN: 1568-2609, 1568-8260), 2003 Jan; 116: 41-63.
Impact Factor: 5.664
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Bonomo RP, Impellizzeri G, La Mendola D, Maccarone G, Pappalardo G, Santoro A, Tabbì G, Vecchio G, Rizzarelli E
* Functional mimics of Cu, Zn-superoxide dismutase enzymes (269 views)
In Complex Environmentsmetal Ligand Interactions (ISSN: 1568-2609, 1568-8260), 2003; 116: 41-63.
Impact Factor: 5.664
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Bonomo RP, Bruno V, Conte E, De Guidi G, La Mendola D, Maccarrone G, Nicoletti F, Rizzarelli E, Sortino S, Vecchio G
* Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (391 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2003; (23): 4406-4415.
Impact Factor: 2.908
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La Mendola D, Sortino S, Rizzarelli E, Vecchiog
* Synthesis Of New Carnosine Derivatives Of R-Cyclodextrin And Their Hydroxyl Radical Scavanger Ability (364 views)
Helvetica Chimica Acta, 2002; 85: 1633-1643.
Impact Factor: 1.394
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Tabbì G, Fry SC, Bonomo RP
ESR study of the non-enzymic scission of xyloglucan by an ascorbate-H2O2-copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (343 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Apr; 84(3-4): 179-187.
Impact Factor: 1.729
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Tabbì G, Nauser T, Koppenol WH, Reedijk J
A Pulse Radiolysis Study of an Imidazolato-Bridged Asymmetric Dicopper(II) Complex: A Structural and Functional Mimic of Superoxide Dismutase (295 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 1998; (12): 1939-1943.
Impact Factor: 2.222
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Bonomo RP, Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Tabbì G
Co-ordinating properties of cyclopeptides. Thermodynamic and spectroscopic study on the formation of copper(II) complexes with cyclo(Gly-His)4 and cyclo(Gly-His-Gly)2 and their superoxide dismutase-like activity (460 views)
Journal Of The Chemical Society Dalton Transactions (ISSN: 0300-9246), 1998; (22): 3851-3857.
Impact Factor: 2.507
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Wink DA, Cook JA, Kim SY, Vodovotz Y, Pacelli R, Krishna MC, Russo A, Mitchell JB, Jourd'heuil D, Miles AM, Grisham MB
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates (473 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1997 Apr 25; 272(17): 11147-11151.
Impact Factor: 6.963
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Tabbì G, Driessen WL, Reedijk J, Bonomo RP, Veldman N, Spek AL
High Superoxide Dismutase Activity Of A Novel, Intramolecularly Imidazolato-Bridged Asymmetric Dicopper(ii) Species; Design, Synthesis, Structure And Magnetism Of Cu(ii) Complexes With A Mixed Pyrazole-Imidazole Donor Set (323 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 1997; 36(6): 1168-1175.
Impact Factor: 2.736
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Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (599 views)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (449 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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Miles AM, Gibson MF, Kirshina M, Cook JC, Pacelli R, Wink D, Grisham MB
Effects of superoxide on nitric oxide-dependent n-nitrosation reactions (298 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 1995 Oct; 23(4): 379-390.
Impact Factor: 2.361
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Vinci C, Caltabiano V, Santoro AM, Rabuazzo AM, Buscema M, Purrello R, Rizzarelli E, Vigneri R, Purrello F
Copper Addition Prevents The Inhibitory Effects Of Interleukin 1-Beta On Rat Pancreatic Islets (452 views)
Diabetologia, 1995 Jan; 38(1): 39-45.
Impact Factor: 0
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Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (509 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
Impact Factor: 1.342
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Bonomo RP, Conte E, Marchelli R, Santoro AM, Tabbì G
O2 - scavenger properties of copper(II) complexes with diamino-diamide-type ligands (372 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Feb 1; 53(2): 127-138.
Impact Factor: 1.342
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Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
Determination of superoxide dismutase-like activity of copper(II) complexes. Relevance of the speciation for the correct interpretation of in vitro O2 - scavenger activity (614 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Jun; 50(4): 273-281.
Impact Factor: 1.342
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38 Records (38 excluding Abstracts).
Total impact factor: 125.21 (125.21 excluding Abstracts).
Total 5 year impact factor: 140.947 (140.947 excluding Abstracts).
Total impact factor: 125.21 (125.21 excluding Abstracts).
Total 5 year impact factor: 140.947 (140.947 excluding Abstracts).
849 views. Last view on Wednesday 29 November 2023, 6:27:38
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