A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor(461 views) Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Ist. di Biostrutture e Bioimmagini, Dipartimento di Chimica Biologica, Univ. Federico II di Napoli, Via Mezzocannone 6, 80134 Naples, Italy
Dipto. di Biochimica e Biofisica, C.R.I.S.C.E.B., Seconda Università di Napoli, Via Costantinopoli 16, 80138 Naples, Italy
References: Not available.
A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor
We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4{29-39}. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, performed in the presence of micellar detergents to model a membrane-like environment, show that the (1-17) segment of SDF-1 binds to CXCR4{29-39}.
A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor