Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (880 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Evaluation Studies, Research Support, Non-U. S. Gov'T,
Impact factor: 6.747, 5-year impact factor: 6.768
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-69349090351&partnerID=40&md5=b8e4ee8a19e5408fc3c87429a3ba297c
Keywords: Alphavbeta5 Integrin, Arginylglycylaspartic Acid, Chimeric Protein, Echistatin, Fluorine 18, Indium 111, Iodine 125, Pentapeptide, Pentetic Acid, Vitronectin Receptor, Amino Acid Sequence, Animal Experiment, Animal Model, Binding Assay, Carboxy Terminal Sequence, Cell Adhesion, Cell Membrane, Conjugation, Controlled Study, Human, Human Cell, Isotope Labeling, Molecular Weight, Mouse, Nonhuman, Positron Emission Tomography, Priority Journal, Protein Binding, Protein Function, Single Photon Emission Computer Tomography, Tumor Xenograft, Glioblastoma, Integrin Alphavbeta3, Iodine Radioisotopes, K562 Cells, Inbred Balb C, Nude, Oligopeptides, Positron-Emission Tomography, Recombinant Fusion Proteins, Substrate Specificity, Transplantation, Heterologous, Tumor Cells, Cultured, Glioblastoma Metabolism Pathology Radionuclide Imaging, Integrin Alphavbeta3 Analysis Metabolism, Iodine Radioisotopes Diagnostic Use Metabolism, Oligopeptides Analysis Metabolism, Peptides Chemistry Metabolism, Positron-Emission Tomography Methods, Vitronectin Metabolism, Recombinant Fusion Proteins Metabolism,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimages, National Research Council, University of Naples Federico II, Naples, Italy
Department of Biomorphological and Functional Sciences, University of Naples Federico II, Edificio 10, Via S. Pansini 5, 80131 Naples, Italy
Department of Pharmaceutical Chemistry and Toxicology, University of Naples Federico II, Naples, Italy
References:
Avraamides, C.J., Garmy-Susini, B., Varner, J.A., Integrins in angiogenesis and lymphangiogenesis (2008) Nat Rev Cancer, 8, pp. 604-61
Hood, J.D., Cheresh, D.A., Role of integrins in cell invasion and migration (2002) Nature Reviews Cancer, 2 (2), pp. 91-100
Guo, W., Giancotti, F.G., Integrin signalling during tumour progression (2004) Nat Rev Mol Cell Biol, 5, pp. 816-826
Stupack, D.G., Cheresh, D.A., Get a ligand, get a life: Integrins, signaling and cell survival (2002) J Cell Sci, 115, pp. 3729-3738
Friedlander, M., Brooks, P.C., Shaffer, R.W., Kincaid, C.M., Varner, J.A., Cheresh, D.A., Definition of two angiogenic pathways by distinct alphav integrins (1995) Science, 270 (5241), pp. 1500-1502
Hood, J.D., Frausto, R., Kiosses, W.B., Schwartz, M.A., Cheresh, D.A., Differential αv integrin-mediated Ras-ERK signaling during two pathways of angiogenesis (2003) Journal of Cell Biology, 162 (5), pp. 933-943. , DOI 10.1083/jcb.200304105
Shimaoka, M., Springer, T.A., Therapeutic antagonists and conformational regulation of integrin function (2003) Nature Reviews Drug Discovery, 2 (9), pp. 703-716
Xiong, J.-P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D.L., Joachimiak, A., Arnaout, M.A., Crystal structure of the extracettutar segment of integrin αVβ3 (2001) Science, 294 (5541), pp. 339-345. , DOI 10.1126/science.1064535
Mahabeleshwar, G.H., Feng, W., Reddy, K., Plow, E.F., Byzova, T.V., Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis (2007) Circulation Research, 101 (6), pp. 570-580. , DOI 10.1161/CIRCRESAHA.107.155655
Byzova, T.V., Goldman, C.K., Pampori, N., A mechanism for modulation of cellular responses to VEGF: Activation of the integrins (2000) Mol Cell, 6, pp. 851-860
Albelda, S.M., Mette, S.A., Elder, D.E., Integrin distribution in malignant melanoma: Association of the β3 subunit with tumor progression (1990) Cancer Res, 50, pp. 6757-6764
Schnell, O., Krebs, B., Wagner, E., Romagna, A., Beer, A.J., Grau, S.J., Thon, N., Goldbrunner, R.H., Expression of integrin αvβ3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature (2008) Brain Pathology, 18 (3), pp. 378-386. , DOI 10.1111/j.1750-3639.2008.00137.x
Liapis, H., Adler, L.M., Wick, M.R., Rader, J.S., Expression of α(v)β3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomas (1997) Hum Pathol, 28, pp. 443-449
Gasparini, G., Brooks, P.C., Biganzoli, E., Vascular integrin α(v)β3: A new prognostic indicator in breast cancer (1998) Clin Cancer Res, 4, pp. 2625-2634
Felding-Habermann, B., O'Toole, T.E., Smith, J.W., Fransvea, E., Ruggeri, Z.M., Ginsberg, M.H., Hughes, P.E., Mueller, B.M., Integrin activation controls metastasis in human breast cancer (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (4), pp. 1853-1858. , DOI 10.1073/pnas.98.4.1853
Rolli, M., Fransvea, E., Pilch, J., Saven, A., Felding-Habermann, B., Activated integrin αvβ3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (16), pp. 9482-9487. , DOI 10.1073/pnas.1633689100
Carriero, M.V., Del Vecchio, S., Capozzoli, M., Urokinase receptor interacts with α(v)β5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer (1999) Cancer Res, 59, pp. 5307-5314
Monnier, Y., Farmer, P., Bieler, G., CYR61 and αVβ5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma (2008) Cancer Res, 68, pp. 7323-7331
Chen, X., Conti, P.S., Moats, R.A., In vivo near-infrared fluorescence imaging of integrin αvβ3 in brain tumor xenografts (2004) Cancer Res, 64, pp. 8009-8014
Sipkins, D.A., Cheresh, D.A., Kazemi, M.R., Nevin, L.M., Bednarski, M.D., Li, K.C.P., Detection of tumor angiogenesis in vivo by α(v)β3- targeted magnetic resonance imaging (1998) Nature Medicine, 4 (5), pp. 623-626. , DOI 10.1038/nm0598-623
Zhang, C., Jugold, M., Woenne, E.C., Lammers, T., Morgenstern, B., Mueller, M.M., Zentgraf, H., Kiessling, F., Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner (2007) Cancer Research, 67 (4), pp. 1555-1562. , DOI 10.1158/0008-5472.CAN-06-1668
Ellegala, D.B., Leong-Poi, H., Carpenter, J.E., Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to α(v)β3 (2003) Circulation, 108, pp. 336-341
Janssen, M.L., Oyen, W.J., Dijkgraaf, I., Tumor targeting with radiolabeled α(v)β(3) integrin binding peptides in a nude mouse model (2002) Cancer Res, 62, pp. 6146-6151
Haubner, R., Wester, H.J., Weber, W.A., Non-invasive imaging of α(v)β3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography (2001) Cancer Res, 61, pp. 1781-1785
Chen, X., Hou, Y., Tohme, M., Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor αvβ3-integrin expression (2004) J Nucl Med, 45, pp. 1776-1783
Cai, W., Wu, Y., Chen, K., Cao, Q., Tice, D.A., Chen, X., In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin αvβ3 (2006) Cancer Res, 66, pp. 9673-9681
Haubner, R., Weber, W.A., Beer, A.J., Vabuliene, E., Reim, D., Sarbia, M., Becker, K.-F., Schwaiger, M., Noninvasive visualization of the activated αvβ3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD (2005) PLoS Medicine, 2 (3), pp. 244-252. , http://medicine.plosjournals.org/archive/1549-1676/2/3/pdf/10. 1371_journal.pmed.0020070-L.pdf, DOI 10.1371/journal.pmed.0020070, 3
Beer, A.J., Grosu, A.-L., Carlsen, J., Kolk, A., Sarbia, M., Stangier, I., Watzlowik, P., Schwaiger, M., [18F]Galacto-RGD positron emission tomography for imaging of αvβ3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck (2007) Clinical Cancer Research, 13 (22), pp. 6610-6616. , http://clincancerres.aacrjournals.org/cgi/reprint/13/22/6610, DOI 10.1158/1078-0432.CCR-07-0528
Del Gatto, A., Zaccaro, L., Grieco, P., Novel and selective α(v)β3 receptor peptide antagonist: Design, synthesis, and biological behavior (2006) J Med Chem, 49, pp. 3416-3420
De Luca, S., Morelli, G., Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (2004) Journal of Peptide Science, 10 (5), pp. 265-273. , DOI 10.1002/psc.527
Lang, L., Eckelman, W.C., One-step synthesis of 18F labeled [18F]-N-succinimidyl 4-(fluoromethyl)benzoate for protein labeling (1994) Appl Radiat Isot, 45, pp. 1155-1163
Blystone, S.D., Lindberg, F.P., LaFlamme, S.E., Brown, E.J., Integrin β3 cytoplasmic tail is necessary and sufficient for regulation of α5β1 phagocytosis by αvβ3 and integrin-associated protein (1995) J Cell Biol, 130, pp. 745-754
Zannetti, A., Iommelli, F., Fonti, R., Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type 3 (2008) Clin Cancer Res, 14, pp. 5209-5219
Del Vecchio, S., Stoppelli, M.P., Carriero, M.V., Fonti, R., Massa, O., Pei Yong, L., Botti, G., Salvatore, M., Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (1993) Cancer Research, 53 (13), pp. 3198-3206
Thibault, G., Sodium dodecyl sulfate-stable complexes of echistatin and RGD-dependent integrins: A novel approach to study integrins (2000) Molecular Pharmacology, 58 (5), pp. 1137-1145
McQuade, P., Knight, L.C., Radiopharmaceuticals for targeting the angiogenesis marker α(v)β(3) (2003) Q J Nucl Med, 47, pp. 209-220
Beer, A.J., Schwaiger, M., Imaging of integrin αvβ3 expression (2008) Cancer Metastasis Rev, 27, pp. 631-644
Wu, Y., Zhang, X., Xiong, Z., MicroPET imaging of glioma integrin {α}v{β}3 expression using (64)Cu-labeled tetrameric RGD peptide (2005) J Nucl Med, 46, pp. 1707-1718
Goodman, S.L., Holzemann, G., Sulyok, G.A., Kessler, H., Nanomolar small molecule inhibitors for αv(β) 6, αv(β)5, and αv(β)3 integrins (2002) J Med Chem, 45, pp. 1045-1051
Li, Z.B., Chen, K., Chen, X., (68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin α(v)β(3) expression (2008) Eur J Nucl Med Mol Imaging, 35, pp. 1100-1108
Nabors, L.B., Mikkelsen, T., Rosenfeld, S.S., Hochberg, F., Akella, N.S., Fisher, J.D., Cloud, G.A., Grossman, S.A., Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma (2007) Journal of Clinical Oncology, 25 (13), pp. 1651-1657. , DOI 10.1200/JCO.2006.06.6514
Mizejewski, G.J., Role of integrins in cancer: Survey of expression patterns (1999) Proceedings of the Society for Experimental Biology and Medicine, 222 (2), pp. 124-138
Wakayama, M., Abei, M., Kawashima, R., E1A, E1B double-restricted adenovirus with RGD-fiber modification exhibits enhanced oncolysis for CAR-deficient biliary cancers (2007) Clin Cancer Res, 13, pp. 3043-3050
Pasqualini, R., Bodorova, J., Ye, S., Hemler, M.E., A study of the structure, function and distribution of β5 integrins using novel anti-β5 monoclonal antibodies (1993) Journal of Cell Science, 105 (1), pp. 101-111
Burvenich, I.J., Schoonooghe, S., Blanckaert, P., Biodistribution and planar γ camera imaging of (123)I- and (131)I-labeled F(ab')(2) and Fab fragments of monoclonal antibody 14C5 in nude mice bearing an A549 lung tumor (2007) Nucl Med Biol, 34, pp. 257-265
Avraamides, C. J., Garmy-Susini, B., Varner, J. A., Integrins in angiogenesis and lymphangiogenesis (2008) Nat Rev Cancer, 8, pp. 604-61
Hood, J. D., Cheresh, D. A., Role of integrins in cell invasion and migration (2002) Nature Reviews Cancer, 2 (2), pp. 91-100
Stupack, D. G., Cheresh, D. A., Get a ligand, get a life: Integrins, signaling and cell survival (2002) J Cell Sci, 115, pp. 3729-3738
Hood, J. D., Frausto, R., Kiosses, W. B., Schwartz, M. A., Cheresh, D. A., Differential v integrin-mediated Ras-ERK signaling during two pathways of angiogenesis (2003) Journal of Cell Biology, 162 (5), pp. 933-943. , DOI 10. 1083/jcb. 200304105
Xiong, J. -P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D. L., Joachimiak, A., Arnaout, M. A., Crystal structure of the extracettutar segment of integrin V 3 (2001) Science, 294 (5541), pp. 339-345. , DOI 10. 1126/science. 1064535
Mahabeleshwar, G. H., Feng, W., Reddy, K., Plow, E. F., Byzova, T. V., Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis (2007) Circulation Research, 101 (6), pp. 570-580. , DOI 10. 1161/CIRCRESAHA. 107. 155655
Byzova, T. V., Goldman, C. K., Pampori, N., A mechanism for modulation of cellular responses to VEGF: Activation of the integrins (2000) Mol Cell, 6, pp. 851-860
Albelda, S. M., Mette, S. A., Elder, D. E., Integrin distribution in malignant melanoma: Association of the 3 subunit with tumor progression (1990) Cancer Res, 50, pp. 6757-6764
Carriero, M. V., Del Vecchio, S., Capozzoli, M., Urokinase receptor interacts with (v) 5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer (1999) Cancer Res, 59, pp. 5307-5314
Sipkins, D. A., Cheresh, D. A., Kazemi, M. R., Nevin, L. M., Bednarski, M. D., Li, K. C. P., Detection of tumor angiogenesis in vivo by (v) 3- targeted magnetic resonance imaging (1998) Nature Medicine, 4 (5), pp. 623-626. , DOI 10. 1038/nm0598-623
Ellegala, D. B., Leong-Poi, H., Carpenter, J. E., Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to (v) 3 (2003) Circulation, 108, pp. 336-341
Janssen, M. L., Oyen, W. J., Dijkgraaf, I., Tumor targeting with radiolabeled (v) (3) integrin binding peptides in a nude mouse model (2002) Cancer Res, 62, pp. 6146-6151
Beer, A. J., Grosu, A. -L., Carlsen, J., Kolk, A., Sarbia, M., Stangier, I., Watzlowik, P., Schwaiger, M., [18F] Galacto-RGD positron emission tomography for imaging of v 3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck (2007) Clinical Cancer Research, 13 (22), pp. 6610-6616. , http: //clincancerres. aacrjournals. org/cgi/reprint/13/22/6610, DOI 10. 1158/1078-0432. CCR-07-0528
Blystone, S. D., Lindberg, F. P., LaFlamme, S. E., Brown, E. J., Integrin 3 cytoplasmic tail is necessary and sufficient for regulation of 5 1 phagocytosis by v 3 and integrin-associated protein (1995) J Cell Biol, 130, pp. 745-754
Beer, A. J., Schwaiger, M., Imaging of integrin v 3 expression (2008) Cancer Metastasis Rev, 27, pp. 631-644
Goodman, S. L., Holzemann, G., Sulyok, G. A., Kessler, H., Nanomolar small molecule inhibitors for v () 6, v () 5, and v () 3 integrins (2002) J Med Chem, 45, pp. 1045-1051
Li, Z. B., Chen, K., Chen, X., (68) Ga-labeled multimeric RGD peptides for microPET imaging of integrin (v) (3) expression (2008) Eur J Nucl Med Mol Imaging, 35, pp. 1100-1108
Nabors, L. B., Mikkelsen, T., Rosenfeld, S. S., Hochberg, F., Akella, N. S., Fisher, J. D., Cloud, G. A., Grossman, S. A., Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma (2007) Journal of Clinical Oncology, 25 (13), pp. 1651-1657. , DOI 10. 1200/JCO. 2006. 06. 6514
Mizejewski, G. J., Role of integrins in cancer: Survey of expression patterns (1999) Proceedings of the Society for Experimental Biology and Medicine, 222 (2), pp. 124-138
Burvenich, I. J., Schoonooghe, S., Blanckaert, P., Biodistribution and planar camera imaging of (123) I- and (131) I-labeled F (ab') (2) and Fab fragments of monoclonal antibody 14C5 in nude mice bearing an A549 lung tumor (2007) Nucl Med Biol, 34, pp. 257-265
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Evaluation Studies, Research Support, Non-U. S. Gov'T,
Impact factor: 6.747, 5-year impact factor: 6.768
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-69349090351&partnerID=40&md5=b8e4ee8a19e5408fc3c87429a3ba297c
Keywords: Alphavbeta5 Integrin, Arginylglycylaspartic Acid, Chimeric Protein, Echistatin, Fluorine 18, Indium 111, Iodine 125, Pentapeptide, Pentetic Acid, Vitronectin Receptor, Amino Acid Sequence, Animal Experiment, Animal Model, Binding Assay, Carboxy Terminal Sequence, Cell Adhesion, Cell Membrane, Conjugation, Controlled Study, Human, Human Cell, Isotope Labeling, Molecular Weight, Mouse, Nonhuman, Positron Emission Tomography, Priority Journal, Protein Binding, Protein Function, Single Photon Emission Computer Tomography, Tumor Xenograft, Glioblastoma, Integrin Alphavbeta3, Iodine Radioisotopes, K562 Cells, Inbred Balb C, Nude, Oligopeptides, Positron-Emission Tomography, Recombinant Fusion Proteins, Substrate Specificity, Transplantation, Heterologous, Tumor Cells, Cultured, Glioblastoma Metabolism Pathology Radionuclide Imaging, Integrin Alphavbeta3 Analysis Metabolism, Iodine Radioisotopes Diagnostic Use Metabolism, Oligopeptides Analysis Metabolism, Peptides Chemistry Metabolism, Positron-Emission Tomography Methods, Vitronectin Metabolism, Recombinant Fusion Proteins Metabolism,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimages, National Research Council, University of Naples Federico II, Naples, Italy
Department of Biomorphological and Functional Sciences, University of Naples Federico II, Edificio 10, Via S. Pansini 5, 80131 Naples, Italy
Department of Pharmaceutical Chemistry and Toxicology, University of Naples Federico II, Naples, Italy
References:
Avraamides, C.J., Garmy-Susini, B., Varner, J.A., Integrins in angiogenesis and lymphangiogenesis (2008) Nat Rev Cancer, 8, pp. 604-61
Hood, J.D., Cheresh, D.A., Role of integrins in cell invasion and migration (2002) Nature Reviews Cancer, 2 (2), pp. 91-100
Guo, W., Giancotti, F.G., Integrin signalling during tumour progression (2004) Nat Rev Mol Cell Biol, 5, pp. 816-826
Stupack, D.G., Cheresh, D.A., Get a ligand, get a life: Integrins, signaling and cell survival (2002) J Cell Sci, 115, pp. 3729-3738
Friedlander, M., Brooks, P.C., Shaffer, R.W., Kincaid, C.M., Varner, J.A., Cheresh, D.A., Definition of two angiogenic pathways by distinct alphav integrins (1995) Science, 270 (5241), pp. 1500-1502
Hood, J.D., Frausto, R., Kiosses, W.B., Schwartz, M.A., Cheresh, D.A., Differential αv integrin-mediated Ras-ERK signaling during two pathways of angiogenesis (2003) Journal of Cell Biology, 162 (5), pp. 933-943. , DOI 10.1083/jcb.200304105
Shimaoka, M., Springer, T.A., Therapeutic antagonists and conformational regulation of integrin function (2003) Nature Reviews Drug Discovery, 2 (9), pp. 703-716
Xiong, J.-P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D.L., Joachimiak, A., Arnaout, M.A., Crystal structure of the extracettutar segment of integrin αVβ3 (2001) Science, 294 (5541), pp. 339-345. , DOI 10.1126/science.1064535
Mahabeleshwar, G.H., Feng, W., Reddy, K., Plow, E.F., Byzova, T.V., Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis (2007) Circulation Research, 101 (6), pp. 570-580. , DOI 10.1161/CIRCRESAHA.107.155655
Byzova, T.V., Goldman, C.K., Pampori, N., A mechanism for modulation of cellular responses to VEGF: Activation of the integrins (2000) Mol Cell, 6, pp. 851-860
Albelda, S.M., Mette, S.A., Elder, D.E., Integrin distribution in malignant melanoma: Association of the β3 subunit with tumor progression (1990) Cancer Res, 50, pp. 6757-6764
Schnell, O., Krebs, B., Wagner, E., Romagna, A., Beer, A.J., Grau, S.J., Thon, N., Goldbrunner, R.H., Expression of integrin αvβ3 in gliomas correlates with tumor grade and is not restricted to tumor vasculature (2008) Brain Pathology, 18 (3), pp. 378-386. , DOI 10.1111/j.1750-3639.2008.00137.x
Liapis, H., Adler, L.M., Wick, M.R., Rader, J.S., Expression of α(v)β3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomas (1997) Hum Pathol, 28, pp. 443-449
Gasparini, G., Brooks, P.C., Biganzoli, E., Vascular integrin α(v)β3: A new prognostic indicator in breast cancer (1998) Clin Cancer Res, 4, pp. 2625-2634
Felding-Habermann, B., O'Toole, T.E., Smith, J.W., Fransvea, E., Ruggeri, Z.M., Ginsberg, M.H., Hughes, P.E., Mueller, B.M., Integrin activation controls metastasis in human breast cancer (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (4), pp. 1853-1858. , DOI 10.1073/pnas.98.4.1853
Rolli, M., Fransvea, E., Pilch, J., Saven, A., Felding-Habermann, B., Activated integrin αvβ3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (16), pp. 9482-9487. , DOI 10.1073/pnas.1633689100
Carriero, M.V., Del Vecchio, S., Capozzoli, M., Urokinase receptor interacts with α(v)β5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer (1999) Cancer Res, 59, pp. 5307-5314
Monnier, Y., Farmer, P., Bieler, G., CYR61 and αVβ5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma (2008) Cancer Res, 68, pp. 7323-7331
Chen, X., Conti, P.S., Moats, R.A., In vivo near-infrared fluorescence imaging of integrin αvβ3 in brain tumor xenografts (2004) Cancer Res, 64, pp. 8009-8014
Sipkins, D.A., Cheresh, D.A., Kazemi, M.R., Nevin, L.M., Bednarski, M.D., Li, K.C.P., Detection of tumor angiogenesis in vivo by α(v)β3- targeted magnetic resonance imaging (1998) Nature Medicine, 4 (5), pp. 623-626. , DOI 10.1038/nm0598-623
Zhang, C., Jugold, M., Woenne, E.C., Lammers, T., Morgenstern, B., Mueller, M.M., Zentgraf, H., Kiessling, F., Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner (2007) Cancer Research, 67 (4), pp. 1555-1562. , DOI 10.1158/0008-5472.CAN-06-1668
Ellegala, D.B., Leong-Poi, H., Carpenter, J.E., Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to α(v)β3 (2003) Circulation, 108, pp. 336-341
Janssen, M.L., Oyen, W.J., Dijkgraaf, I., Tumor targeting with radiolabeled α(v)β(3) integrin binding peptides in a nude mouse model (2002) Cancer Res, 62, pp. 6146-6151
Haubner, R., Wester, H.J., Weber, W.A., Non-invasive imaging of α(v)β3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography (2001) Cancer Res, 61, pp. 1781-1785
Chen, X., Hou, Y., Tohme, M., Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor αvβ3-integrin expression (2004) J Nucl Med, 45, pp. 1776-1783
Cai, W., Wu, Y., Chen, K., Cao, Q., Tice, D.A., Chen, X., In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin αvβ3 (2006) Cancer Res, 66, pp. 9673-9681
Haubner, R., Weber, W.A., Beer, A.J., Vabuliene, E., Reim, D., Sarbia, M., Becker, K.-F., Schwaiger, M., Noninvasive visualization of the activated αvβ3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD (2005) PLoS Medicine, 2 (3), pp. 244-252. , http://medicine.plosjournals.org/archive/1549-1676/2/3/pdf/10. 1371_journal.pmed.0020070-L.pdf, DOI 10.1371/journal.pmed.0020070, 3
Beer, A.J., Grosu, A.-L., Carlsen, J., Kolk, A., Sarbia, M., Stangier, I., Watzlowik, P., Schwaiger, M., [18F]Galacto-RGD positron emission tomography for imaging of αvβ3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck (2007) Clinical Cancer Research, 13 (22), pp. 6610-6616. , http://clincancerres.aacrjournals.org/cgi/reprint/13/22/6610, DOI 10.1158/1078-0432.CCR-07-0528
Del Gatto, A., Zaccaro, L., Grieco, P., Novel and selective α(v)β3 receptor peptide antagonist: Design, synthesis, and biological behavior (2006) J Med Chem, 49, pp. 3416-3420
De Luca, S., Morelli, G., Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (2004) Journal of Peptide Science, 10 (5), pp. 265-273. , DOI 10.1002/psc.527
Lang, L., Eckelman, W.C., One-step synthesis of 18F labeled [18F]-N-succinimidyl 4-(fluoromethyl)benzoate for protein labeling (1994) Appl Radiat Isot, 45, pp. 1155-1163
Blystone, S.D., Lindberg, F.P., LaFlamme, S.E., Brown, E.J., Integrin β3 cytoplasmic tail is necessary and sufficient for regulation of α5β1 phagocytosis by αvβ3 and integrin-associated protein (1995) J Cell Biol, 130, pp. 745-754
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Nabors, L. B., Mikkelsen, T., Rosenfeld, S. S., Hochberg, F., Akella, N. S., Fisher, J. D., Cloud, G. A., Grossman, S. A., Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma (2007) Journal of Clinical Oncology, 25 (13), pp. 1651-1657. , DOI 10. 1200/JCO. 2006. 06. 6514
Mizejewski, G. J., Role of integrins in cancer: Survey of expression patterns (1999) Proceedings of the Society for Experimental Biology and Medicine, 222 (2), pp. 124-138
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Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5
Purpose: To test whether a novel bifunctional chimeric peptide comprising a cyclic Arg-Gly-Asp pentapeptide covalently bound to an echistatin domain can discriminate αvβ3 from α vβ5 integrin, thus allowing the in vivo selective visualization of αvβ3 expression by single-photon and positron emission tomography (PET) imaging. Experimental Design: The chimeric peptide was preliminarily tested for inhibition of αvβ3-dependent cell adhesion and competition of 125I-echistatin binding to membrane of stably transfected K562 cells expressing αvβ3 (Kαvλ 3) or αvβ5 (Kα vβ5) integrin. The chimeric peptide was then conjugated with diethylenetriaminepentaacetic acid and labeled with 111In for single-photon imaging, whereas a one-step procedure was used for labeling the full-length peptide and a truncated derivative, lacking the last five C-terminal amino acids, with 18F for PET imaging. Nude mice bearing tumors from Kαvβ3, Kαvβ5, U87MG human glioblastoma, and A431 human epidermoid cells were subjected to single-photon and PET imaging. Results: Adhesion and competitive binding assays showed that the novel chimeric peptide selectively binds to αvβ3 integrin and does not cross-react with αvβ5. In agreement with in vitro findings, single-photon and PET imaging studies showed that the radiolabeled chimeric peptide selectively localizes in tumor xenografts expressing αvβ3 and fails to accumulate in those expressing αvβ5 integrin. When 18F-labeled truncated derivative was used for PET imaging, αvβ3- and αvβ 5-expressing tumors were visualized, indicating that the five C-terminal amino acids are required to differentially bind the two integrins. Conclusion: Our findings indicate that the novel chimeric Arg-Gly-Asp peptide, having no cross-reaction with αvβ5 integrin, allows highly selective αvβ3 expression imaging and monitoring. © 2009 American Association for Cancer Research.
Purpose: To test whether a novel bifunctional chimeric peptide comprising a cyclic Arg-Gly-Asp pentapeptide covalently bound to an echistatin domain can discriminate αvβ3 from α vβ5 integrin, thus allowing the in vivo selective visualization of αvβ3 expression by single-photon and positron emission tomography (PET) imaging. Experimental Design: The chimeric peptide was preliminarily tested for inhibition of αvβ3-dependent cell adhesion and competition of 125I-echistatin binding to membrane of stably transfected K562 cells expressing αvβ3 (Kαvλ 3) or αvβ5 (Kα vβ5) integrin. The chimeric peptide was then conjugated with diethylenetriaminepentaacetic acid and labeled with 111In for single-photon imaging, whereas a one-step procedure was used for labeling the full-length peptide and a truncated derivative, lacking the last five C-terminal amino acids, with 18F for PET imaging. Nude mice bearing tumors from Kαvβ3, Kαvβ5, U87MG human glioblastoma, and A431 human epidermoid cells were subjected to single-photon and PET imaging. Results: Adhesion and competitive binding assays showed that the novel chimeric peptide selectively binds to αvβ3 integrin and does not cross-react with αvβ5. In agreement with in vitro findings, single-photon and PET imaging studies showed that the radiolabeled chimeric peptide selectively localizes in tumor xenografts expressing αvβ3 and fails to accumulate in those expressing αvβ5 integrin. When 18F-labeled truncated derivative was used for PET imaging, αvβ3- and αvβ 5-expressing tumors were visualized, indicating that the five C-terminal amino acids are required to differentially bind the two integrins. Conclusion: Our findings indicate that the novel chimeric Arg-Gly-Asp peptide, having no cross-reaction with αvβ5 integrin, allows highly selective αvβ3 expression imaging and monitoring. © 2009 American Association for Cancer Research.
Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5
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Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5
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Ruggiero A, Smaldone G, Esposito L, Balasco N, Vitagliano L
* Loop size optimization induces a strong thermal stabilization of the thioredoxin fold (193 views)
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Leggiero E, Labruna G, Iaffaldano L, Lombardo B, Greco A, Fiorenza D, Gramanzini M, Montanaro D, Baldi A, Cerullo V, Sacchetti L, Pastore L
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* Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins (263 views)
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Storto G, Gallicchio R, Pellegrino T, Nardelli A, Capacchione D, Sirignano C, Pace L
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Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (561 views)
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Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
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J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
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Guarnieri D, De Capua A, Ventre M, Borzacchiello A, Pedone C, Marasco D, Ruvo M, Netti PA
* Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters (572 views)
Acta Biomaterialia (ISSN: 1878-7568, 1742-7061), 2010 Jul; 6(7): 2532-2539.
Impact Factor: 4.824
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Monfregola L, Saviano M, De Luca S
* Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling (378 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2010 Mar; 16(1): 1-5.
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Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
* Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (534 views)
J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1011 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
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Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (293 views) (PDF 204 views)
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Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (522 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (690 views)
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (490 views)
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Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (265 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
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Wang H, Maurea S, Mainolfi C, Fiore F, Gravina A, Panico M, Bazzicalupo L, Salvatore M
Tc-99m MIBI scintigraphy in patients with lung cancer comparison with CT and fluorine-18 FDG PET imaging (302 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1997 Apr; 22(4): 243-249.
Impact Factor: 0.34
View Export to BibTeX Export to EndNote
* Loop size optimization induces a strong thermal stabilization of the thioredoxin fold (193 views)
Febs J (ISSN: 1742-464xlinking), 2019 May; 286(9): 1752-1764.
Impact Factor: 3.129
View Export to BibTeX Export to EndNote
Leggiero E, Labruna G, Iaffaldano L, Lombardo B, Greco A, Fiorenza D, Gramanzini M, Montanaro D, Baldi A, Cerullo V, Sacchetti L, Pastore L
* Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice (227 views) (PDF 85 views)
Gene Ther (ISSN: 0969-7128linking), 2019 Jan 30; 26(3-4): 121-130.
Impact Factor: 4.782
View Export to BibTeX Export to EndNote
Monti M, De Rosa V, Iommelli F, Carriero MV, Terlizzi C, Camerlingo R, Belli S, Fonti R, Di Minno G, Del Vecchio S
* Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins (263 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2018 Aug 9; 19(8): N/D-N/D.
Impact Factor: 3.687
View Export to BibTeX Export to EndNote
Storto G, Gallicchio R, Pellegrino T, Nardelli A, Capacchione D, Sirignano C, Pace L
* Impact of F-18-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP (346 views) (PDF 10 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897, 0969-8051linking), 2013 May; 40(4): 518-523.
Impact Factor: 2.408
View Export to BibTeX Export to EndNote
Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (561 views)
Bioconjug Chem (ISSN: 1520-4812, 1043-1802, 1520-4812electronic), 2012 Mar 21; 23(3): 340-349.
Impact Factor: 4.58
View Export to BibTeX Export to EndNote
Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
* Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (419 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (481 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Guarnieri D, De Capua A, Ventre M, Borzacchiello A, Pedone C, Marasco D, Ruvo M, Netti PA
* Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters (572 views)
Acta Biomaterialia (ISSN: 1878-7568, 1742-7061), 2010 Jul; 6(7): 2532-2539.
Impact Factor: 4.824
View Export to BibTeX Export to EndNote
Monfregola L, Saviano M, De Luca S
* Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling (378 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2010 Mar; 16(1): 1-5.
Impact Factor: 1.034
View Export to BibTeX Export to EndNote
Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
* Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (534 views)
J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
Impact Factor: 3.068
View Export to BibTeX Export to EndNote
Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1011 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
View Export to BibTeX Export to EndNote
Takano A, Varrone A, Gulyas B, Karlsson P, Tauscher J, Halldin C
* Mapping of the norepinephrine transporter in man using PET with (S, S)-[F-18]FMeNER-D-2 (293 views) (PDF 204 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2008 Sep 15; 41: 474-482.
Impact Factor: 5.694
View Export to BibTeX Export to EndNote
Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (522 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (690 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (490 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
View Export to BibTeX Export to EndNote
Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (265 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
View Export to BibTeX Export to EndNote
Wang H, Maurea S, Mainolfi C, Fiore F, Gravina A, Panico M, Bazzicalupo L, Salvatore M
Tc-99m MIBI scintigraphy in patients with lung cancer comparison with CT and fluorine-18 FDG PET imaging (302 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1997 Apr; 22(4): 243-249.
Impact Factor: 0.34
View Export to BibTeX Export to EndNote
17 Records (16 excluding Abstracts).
Total impact factor: 64.181 (61.773 excluding Abstracts).
Total 5 year impact factor: 66.862 (64.404 excluding Abstracts).
Total impact factor: 64.181 (61.773 excluding Abstracts).
Total 5 year impact factor: 66.862 (64.404 excluding Abstracts).
880 views. Last view on Saturday 18 March 2023, 3:04:05
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