A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells
A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells(621 views) Sandomenico A, Monti SM, Palumbo R, Ruvo M
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134 Napoli, Italy
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Meltzer, E. O., Grant, J. A., Impact of cetirizine on the burden of allergic rhinitis (1999) Ann. Allergy Asthma Immunol., 83, pp. 455-463
Kinet, J. P., The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology (1999) Annu. Rev. Immunol., 17, pp. 931-972
Garman, S. C., Kinet, J. P., Jardetzky, T. S., Crystal structure of the human high-affinity IgE receptor (1998) Cell, 95, pp. 951-961
Garman, S. C., Wurzburg, B. A., Tarchevskaya, S. S., Kinet, J. P., Jardetzky, T. S., Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha (2000) Nature, 406, pp. 259-266
Garman, S. C., Sechi, S., Kinet, J. P., Jardetzky, T. S., The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms (2001) J. Mol. Biol., 311, pp. 1049-1062
McDonnell, J. M., Calvert, R., Beavil, R. L., Beavil, A. J., Henry, A. J., Sutton, B. J., Gould, H. J., Cowburn, D., The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha (2001) Nat. Struct. Biol., 8, pp. 437-441
Nakamura, G. R., Starovasnik, M. A., Reynolds, M. E., Lowman, H. B., A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor (2001) Biochemistry, 40, pp. 9828-9835
Nakamura, G. R., Reynolds, M. E., Chen, Y. M., Starovasnik, M. A., Lowman, H. B., Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor (2002) Proc. Natl. Acad. Sci. U. S. A., 99, pp. 1303-1308
Hamburger, R. N., Peptide inhibition of the Prausnitz-K stner reaction (1975) Science, 189 (4200), pp. 389-390
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Cook, J. P., Henry, A. J., McDonnell, J. M., Owens, R. J., Sutton, B. J., Gould, H. J., Identification of contact residues in the IgE binding site of human FcepsilonRIalpha (1997) Biochemistry, 36, pp. 15579-15588
Henry, A. J., Cook, J. P., McDonnell, J. M., Mackay, G. A., Shi, J., Sutton, B. J., Gould, H. J., Participation of the N-terminal region of Cepsilon3 in the binding of human IgE to its high-affinity receptor FcepsilonRI (1997) Biochemistry, 36, pp. 15568-15578
Dearman, R. J., Skinner, R. A., Deakin, N., Shaw, D., Kimber, I., Evaluation of an in vitro method for the measurement of specific IgE antibody responses: the rat basophilic leukemia (RBL) cell assay (2005) Toxicology, 206, pp. 195-205
A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells
We have recently reported on a class of IgE-binding peptides designed based on the crystallographic structure of the high affinity Fc epsilon RI. Peptides contain receptor key residues located within the two distinct binding sites for IgE and selectively bind IgE with an affinity ranging between 6 and 60 mu M. We have here designed and characterized a new molecule containing the receptor loops C'-E and B-C and an optimized linker for joining them made of a Lys side chain and a beta-Ala. This new peptide shows an increased affinity (around 30 times) compared to the parent loop C'-E + B-C previously described, while retaining the same two-site mechanism of binding and the same selectivity. It also blocks the binding of IgE to the cell-anchored receptor and efficiently prevents histamine release from mast cells. These properties make the peptide a useful scaffold for the development of new anti-allergic drugs. Copyright (C) 2011 European Peptide Society and John Wiley & Sons, Ltd
A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells
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A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(284 views) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 ViewExport to BibTeXExport to EndNote
Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S * Fusion in Coq(479 views) Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596. Impact Factor:0.415 ViewExport to BibTeXExport to EndNote