Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation(522 views) Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
Keywords: Bcl10-Inhibitory Peptide, Caspase Recruitment Domain (card), Caspase Recruitment Domain-Containing Membrane-Associated Guanylate Kinase (carma), Nuclear Factor κb (nf-κb), Amino Acid Residues, Functional Characterization, In-Cell, Key Component, Lymphoid Cells, Molecular Complexes, Pathological Conditions, Self-Associations, Signal Transduction Pathways, Cell Membranes, Employment, Organic Acids, Transcription Factors, Association Reactions, Caspase Recruitment Domain Signaling Protein, Immunoglobulin Enhancer Binding Protein, Membrane Associated Guanylate Cyclase Kinase, Protein Bcl 10, Bcl10 Protein, Human, Signal Transducing Adaptor Protein, Amino Acid Sequence, Amino Terminal Sequence, Article, Controlled Study, Enzyme Activation, Enzyme Repression, Human Cell, Liquid Chromatography, Priority Journal, Protein Assembly, Protein Domain, Protein Expression, Protein Motif, Protein Protein Interaction, Tandem Mass Spectrometry, Cell Line, Chemistry, Drug Antagonism, Enzyme Linked Immunosorbent Assay, Genetics, Immunoblotting, Immunoprecipitation, Metabolism, Molecular Genetics, Physiology, Protein Binding, Protein Tertiary Structure, Card Signaling Adaptor Proteins, Enzyme-Linked Immunosorbent Assay, Molecular Sequence Data, Nf-Kappa B, Protein Structure, Nuclear Factor B (nf-B),
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini (IBB), CNR, via Mezzocannone 16, 80134 Napoli, Italy
Dipartimento di Scienze Biologiche, Università di Napoli Federico II, via Mezzocannone 16, 80134 Napoli, Italy
BioGeM Consortium, Via Camporeale, 83031 Ariano Irpino, Italy
Centro di Endocrinologia ed Oncologia Sperimentale, 80131 Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy
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Srinivasula, S. M., Ahmad, M., Lin, J. H., Poyet, J. L., Fernandes-Alnemri, T., Tsichlis, P. N., Alnemri, E. S., CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF- B activation and apoptosis (1999) J. Biol. Chem, 274, pp. 17946-17954
Ruefli-Brasse, A. A., Lee, W. P., Hurst, S., Dixit, V. M., Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF- B activation (2004) J. Biol. Chem, 279, pp. 1570-1574
Pomerantz, J. L., Denny, E. M., Baltimore, D., CARD11 mediates factor-specific activation of NF- B by the T cell receptor complex (2002) EMBO J, 21, pp. 5184-5194
Jun, J. E., Wilson, L. E., Vinuesa, C. G., Lesage, S., Blery, M., Miosge, L. A., Cook, M. C., Penninger, J. M., Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis (2003) Immunity, 18, pp. 751-762
Grabiner, B. C., Blonska, M., Lin, P. C., You, Y., Wang, D., Sun, J., Darnay, B. G., Lin, X., CARMA3 deficiency abrogates G protein-coupled receptor-induced NF- B activation (2007) Genes Dev, 21, pp. 984-996
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res, 35, pp. 161-214
Vaughn, D. E., Rodriguez, J., Lazebnik, Y., Joshua-Tor, L., Crystal structure of Apaf-1 caspase recruitment domain: An -helical Greek key fold for apoptotic signaling (1999) J. Mol. Biol, 293, pp. 439-447
Richard, J. P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M. J., Chernomordik, L. V., Lebleu, B., Cell-penetrating peptides: A reevaluation of the mechanism of cellular uptake (2003) J. Biol. Chem, 278, pp. 585-590
Langel, F. D., Jain, N. A., Rossman, J. S., Kingeter, L. M., Kashyap, A. K., Schaefer, B. C., Multiple protein domains mediate interaction between BCL10 and MALT1 (2008) J. Biol. Chem, 283, pp. 32419-32431
Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation