Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (522 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.155, 5-year impact factor: 4.365
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-70249094317&partnerID=40&md5=87926be1bec7103dcecce36cbc1e7a85
Keywords: Bcl10-Inhibitory Peptide, Caspase Recruitment Domain (card), Caspase Recruitment Domain-Containing Membrane-Associated Guanylate Kinase (carma), Nuclear Factor κb (nf-κb), Amino Acid Residues, Functional Characterization, In-Cell, Key Component, Lymphoid Cells, Molecular Complexes, Pathological Conditions, Self-Associations, Signal Transduction Pathways, Cell Membranes, Employment, Organic Acids, Transcription Factors, Association Reactions, Caspase Recruitment Domain Signaling Protein, Immunoglobulin Enhancer Binding Protein, Membrane Associated Guanylate Cyclase Kinase, Protein Bcl 10, Bcl10 Protein, Human, Signal Transducing Adaptor Protein, Amino Acid Sequence, Amino Terminal Sequence, Article, Controlled Study, Enzyme Activation, Enzyme Repression, Human Cell, Liquid Chromatography, Priority Journal, Protein Assembly, Protein Domain, Protein Expression, Protein Motif, Protein Protein Interaction, Tandem Mass Spectrometry, Cell Line, Chemistry, Drug Antagonism, Enzyme Linked Immunosorbent Assay, Genetics, Immunoblotting, Immunoprecipitation, Metabolism, Molecular Genetics, Physiology, Protein Binding, Protein Tertiary Structure, Card Signaling Adaptor Proteins, Enzyme-Linked Immunosorbent Assay, Molecular Sequence Data, Nf-Kappa B, Protein Structure, Nuclear Factor B (nf-B),
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini (IBB), CNR, via Mezzocannone 16, 80134 Napoli, Italy
Dipartimento di Scienze Biologiche, Università di Napoli Federico II, via Mezzocannone 16, 80134 Napoli, Italy
BioGeM Consortium, Via Camporeale, 83031 Ariano Irpino, Italy
Centro di Endocrinologia ed Oncologia Sperimentale, 80131 Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy
References:
Hofmann, K., Bucher, P., Tschopp, J., The CARD domain: A new apoptotic signalling motif (1997) Trends Biochem. Sci, 22, pp. 155-15
Park, H.H., Lo, Y.C., Lin, S.C., Wang, L., Yang, J.K., Wu, H., The death domain superfamily in intracellular signaling of apoptosis and inflammation (2007) Annu. Rev. Immunol, 25, pp. 561-586
Willis, T.G., Jadayel, D.M., Du, M.Q., Peng, H., Perry, A.R., Abdul-Rauf, M., Price, H., Wlodarska, I., Bcl10 is involved in t(1
q32) of MALT B cell lymphoma and mutated in multiple tumor types (1999) Cell, 96, pp. 35-45
Zhang, Q., Siebert, R., Yan, M., Hinzmann, B., Cui, X., Xue, L., Rakestraw, K.M., Weisenburger, D.D., Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1
q32) (1999) Nat. Genet, 22, pp. 63-68
Thome, M., Martinon, F., Hofmann, K., Rubio, V., Steiner, V., Schneider, P., Mattmann, C., Tschopp, J., Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-κB transcription factor and c-Jun N-terminal kinase (1999) J. Biol. Chem, 274, pp. 9962-9968
Yan, M., Lee, J., Schilbach, S., Goddard, A., Dixit, V., mE10, a novel caspase recruitment domain-containing proapoptotic molecule (1999) J. Biol. Chem, 274, pp. 10287-10292
Srinivasula, S.M., Ahmad, M., Lin, J.H., Poyet, J.L., Fernandes-Alnemri, T., Tsichlis, P.N., Alnemri, E.S., CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-κB activation and apoptosis (1999) J. Biol. Chem, 274, pp. 17946-17954
Koseki, T., Inohara, N., Chen, S., Carrio, R., Merino, J., Hottiger, M.O., Nabel, G.J., Nunez, G., CIPER, a novel NFκB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10 (1999) J. Biol. Chem, 274, pp. 9955-9961
Costanzo, A., Guiet, C., Vito, P., c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-κB (1999) J. Biol. Chem, 274, pp. 20127-20132
Ruland, J., Duncan, G.S., Elia, A., del Barco Barrantes, I., Nguyen, L., Plyte, S., Millar, D.G., Mak, T.W., Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure (2001) Cell, 104, pp. 33-42
Ruefli-Brasse, A.A., Lee, W.P., Hurst, S., Dixit, V.M., Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-κB activation (2004) J. Biol. Chem, 279, pp. 1570-1574
Bertin, J., Wang, L., Guo, Y., Jacobson, M.D., Poyet, J.L., Srinivasula, S.M., Merriam, S., Alnemri, E.S., CARD11 and CARD14 are novel caspase recruitment domain (CARD)/ membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-κ (2001) B. J. Biol. Chem, 276, pp. 11877-11882
Gaide, O., Martinon, F., Micheau, O., Bonnet, D., Thome, M., Tschopp, J., Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-κB activation (2001) FEBS Lett, 496, pp. 121-127
Pomerantz, J.L., Denny, E.M., Baltimore, D., CARD11 mediates factor-specific activation of NF-κB by the T cell receptor complex (2002) EMBO J, 21, pp. 5184-5194
McAllister-Lucas, L.M., Inohara, N., Lucas, P.C., Ruland, J., Benito, A., Li, Q., Chen, S., Verma, I.M., Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-κB induction (2001) J. Biol. Chem, 276, pp. 30589-30597
Wang, L., Guo, Y., Huang, W.J., Ke, X., Poyet, J.L., Manji, G.A., Merriam, S., Bertin, J., Card10 is a novel caspase recruitment domain/ membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-κB (2001) J. Biol. Chem, 276, pp. 21405-21409
Bertin, J., Guo, Y., Wang, L., Srinivasula, S.M., Jacobson, M.D., Poyet, J.L., Merriam, S., Robison, K.E., CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-κB (2000) J. Biol. Chem, 275, pp. 41082-41086
Gaide, O., Favier, B., Legler, D.F., Bonnet, D., Brissoni, B., Valitutti, S., Bron, C., Thome, M., CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-κB activation (2002) Nat. Immunol, 3, pp. 836-843
Hara, H., Wada, T., Bakal, C., Kozieradzki, I., Suzuki, S., Suzuki, N., Nghiem, M., Bauer, B., The MAGUK family protein CARD11 is essential for lymphocyte activation (2003) Immunity, 18, pp. 763-775
Wang, D., You, Y., Case, S.M., McAllister-Lucas, L.M., Wang, L., DiStefano, P.S., Nunez, G., Lin, X., A requirement for CARMA1 in TCR-induced NF-κB activation (2002) Nat. Immunol, 3, pp. 830-835
Stilo, R., Liguoro, D., Di Jeso, B., Formisano, S., Consiglio, E., Leonardi, A., Vito, P., Physical and functional interaction of CARMA1 and CARMA3 with Iκ kinase γ-NFκB essential modulator (2004) J. Biol. Chem, 279, pp. 34323-34331
Zhou, H., Wertz, I., O'Rourke, K., Ultsch, M., Seshagiri, S., Eby, M., Xiao, W., Dixit, V.M., Bcl10 activates the NF-κB pathway through ubiquitination of NEMO (2004) Nature, 427, pp. 167-171
Sun, L., Deng, L., Ea, C.K., Xia, Z.P., Chen, Z.J., The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes (2004) Mol. Cell, 14, pp. 289-301
Egawa, T., Albrecht, B., Favier, B., Sunshine, M.J., Mirchandani, K., O'Brien, W., Thome, M., Littman, D.R., Requirement for CARMA1 in antigen receptor-induced NF-κB activation and lymphocyte proliferation (2003) Curr. Biol, 13, pp. 1252-1258
Jun, J.E., Wilson, L.E., Vinuesa, C.G., Lesage, S., Blery, M., Miosge, L.A., Cook, M.C., Penninger, J.M., Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis (2003) Immunity, 18, pp. 751-762
Lenz, G., Davis, R.E., Ngo, V.N., Lam, L., George, T.C., Wright, G.W., Dave, S.S., Rosenwald, A., Oncogenic CARD11 mutations in human diffuse large B cell lymphoma (2008) Science, 319, pp. 1676-1679
Newton, K., Dixit, V.M., Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes (2003) Curr. Biol, 13, pp. 1247-1251
Grabiner, B.C., Blonska, M., Lin, P.C., You, Y., Wang, D., Sun, J., Darnay, B.G., Lin, X., CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-κB activation (2007) Genes Dev, 21, pp. 984-996
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res, 35, pp. 161-214
Stilo, R., Varricchio, E., Liguoro, D., Leonardi, A., Vito, P., A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-κB (2008) J. Cell Sci, 121, pp. 1165-1171
Tornatore, L., Marasco, D., Dathan, N., Vitale, R.M., Benedetti, E., Papa, S., Franzoso, G., Monti, S.M., Gadd45β forms a homodimeric complex that binds tightly to MKK7 (2008) J. Mol. Biol, 378, pp. 97-111
Stilo, R., Leonardi, A., Formisano, L., Di Jeso, B., Vito, P., Liguoro, D., TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-κB activation (2002) FEBS Lett, 521, pp. 165-169
Vaughn, D.E., Rodriguez, J., Lazebnik, Y., Joshua-Tor, L., Crystal structure of Apaf-1 caspase recruitment domain: An α-helical Greek key fold for apoptotic signaling (1999) J. Mol. Biol, 293, pp. 439-447
Richard, J.P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M.J., Chernomordik, L.V., Lebleu, B., Cell-penetrating peptides: A reevaluation of the mechanism of cellular uptake (2003) J. Biol. Chem, 278, pp. 585-590
Rebeaud, F., Hailfinger, S., Posevitz-Fejfar, A., Tapernoux, M., Moser, R., Rueda, D., Gaide, O., Rufer, N., The proteolytic activity of the paracaspase MALT1 is key in T cell activation (2008) Nat. Immunol, 9, pp. 272-281
Langel, F.D., Jain, N.A., Rossman, J.S., Kingeter, L.M., Kashyap, A.K., Schaefer, B.C., Multiple protein domains mediate interaction between BCL10 and MALT1 (2008) J. Biol. Chem, 283, pp. 32419-32431
Wan, F., Anderson, D.E., Barnitz, R.A., Snow, A., Bidere, N., Zheng, L., Hegde, V., Levens, D., Ribosomal protein S3: A KH domain subunit in NF-κB complexes that mediates selective gene regulation (2007) Cell, 131, pp. 927-939
Park, H. H., Lo, Y. C., Lin, S. C., Wang, L., Yang, J. K., Wu, H., The death domain superfamily in intracellular signaling of apoptosis and inflammation (2007) Annu. Rev. Immunol, 25, pp. 561-586
Willis, T. G., Jadayel, D. M., Du, M. Q., Peng, H., Perry, A. R., Abdul-Rauf, M., Price, H., Wlodarska, I., Bcl10 is involved in t (1
Srinivasula, S. M., Ahmad, M., Lin, J. H., Poyet, J. L., Fernandes-Alnemri, T., Tsichlis, P. N., Alnemri, E. S., CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF- B activation and apoptosis (1999) J. Biol. Chem, 274, pp. 17946-17954
Ruefli-Brasse, A. A., Lee, W. P., Hurst, S., Dixit, V. M., Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF- B activation (2004) J. Biol. Chem, 279, pp. 1570-1574
Pomerantz, J. L., Denny, E. M., Baltimore, D., CARD11 mediates factor-specific activation of NF- B by the T cell receptor complex (2002) EMBO J, 21, pp. 5184-5194
Jun, J. E., Wilson, L. E., Vinuesa, C. G., Lesage, S., Blery, M., Miosge, L. A., Cook, M. C., Penninger, J. M., Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis (2003) Immunity, 18, pp. 751-762
Grabiner, B. C., Blonska, M., Lin, P. C., You, Y., Wang, D., Sun, J., Darnay, B. G., Lin, X., CARMA3 deficiency abrogates G protein-coupled receptor-induced NF- B activation (2007) Genes Dev, 21, pp. 984-996
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res, 35, pp. 161-214
Vaughn, D. E., Rodriguez, J., Lazebnik, Y., Joshua-Tor, L., Crystal structure of Apaf-1 caspase recruitment domain: An -helical Greek key fold for apoptotic signaling (1999) J. Mol. Biol, 293, pp. 439-447
Richard, J. P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M. J., Chernomordik, L. V., Lebleu, B., Cell-penetrating peptides: A reevaluation of the mechanism of cellular uptake (2003) J. Biol. Chem, 278, pp. 585-590
Langel, F. D., Jain, N. A., Rossman, J. S., Kingeter, L. M., Kashyap, A. K., Schaefer, B. C., Multiple protein domains mediate interaction between BCL10 and MALT1 (2008) J. Biol. Chem, 283, pp. 32419-32431
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.155, 5-year impact factor: 4.365
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-70249094317&partnerID=40&md5=87926be1bec7103dcecce36cbc1e7a85
Keywords: Bcl10-Inhibitory Peptide, Caspase Recruitment Domain (card), Caspase Recruitment Domain-Containing Membrane-Associated Guanylate Kinase (carma), Nuclear Factor κb (nf-κb), Amino Acid Residues, Functional Characterization, In-Cell, Key Component, Lymphoid Cells, Molecular Complexes, Pathological Conditions, Self-Associations, Signal Transduction Pathways, Cell Membranes, Employment, Organic Acids, Transcription Factors, Association Reactions, Caspase Recruitment Domain Signaling Protein, Immunoglobulin Enhancer Binding Protein, Membrane Associated Guanylate Cyclase Kinase, Protein Bcl 10, Bcl10 Protein, Human, Signal Transducing Adaptor Protein, Amino Acid Sequence, Amino Terminal Sequence, Article, Controlled Study, Enzyme Activation, Enzyme Repression, Human Cell, Liquid Chromatography, Priority Journal, Protein Assembly, Protein Domain, Protein Expression, Protein Motif, Protein Protein Interaction, Tandem Mass Spectrometry, Cell Line, Chemistry, Drug Antagonism, Enzyme Linked Immunosorbent Assay, Genetics, Immunoblotting, Immunoprecipitation, Metabolism, Molecular Genetics, Physiology, Protein Binding, Protein Tertiary Structure, Card Signaling Adaptor Proteins, Enzyme-Linked Immunosorbent Assay, Molecular Sequence Data, Nf-Kappa B, Protein Structure, Nuclear Factor B (nf-B),
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini (IBB), CNR, via Mezzocannone 16, 80134 Napoli, Italy
Dipartimento di Scienze Biologiche, Università di Napoli Federico II, via Mezzocannone 16, 80134 Napoli, Italy
BioGeM Consortium, Via Camporeale, 83031 Ariano Irpino, Italy
Centro di Endocrinologia ed Oncologia Sperimentale, 80131 Napoli, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy
References:
Hofmann, K., Bucher, P., Tschopp, J., The CARD domain: A new apoptotic signalling motif (1997) Trends Biochem. Sci, 22, pp. 155-15
Park, H.H., Lo, Y.C., Lin, S.C., Wang, L., Yang, J.K., Wu, H., The death domain superfamily in intracellular signaling of apoptosis and inflammation (2007) Annu. Rev. Immunol, 25, pp. 561-586
Willis, T.G., Jadayel, D.M., Du, M.Q., Peng, H., Perry, A.R., Abdul-Rauf, M., Price, H., Wlodarska, I., Bcl10 is involved in t(1
q32) of MALT B cell lymphoma and mutated in multiple tumor types (1999) Cell, 96, pp. 35-45
Zhang, Q., Siebert, R., Yan, M., Hinzmann, B., Cui, X., Xue, L., Rakestraw, K.M., Weisenburger, D.D., Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1
q32) (1999) Nat. Genet, 22, pp. 63-68
Thome, M., Martinon, F., Hofmann, K., Rubio, V., Steiner, V., Schneider, P., Mattmann, C., Tschopp, J., Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-κB transcription factor and c-Jun N-terminal kinase (1999) J. Biol. Chem, 274, pp. 9962-9968
Yan, M., Lee, J., Schilbach, S., Goddard, A., Dixit, V., mE10, a novel caspase recruitment domain-containing proapoptotic molecule (1999) J. Biol. Chem, 274, pp. 10287-10292
Srinivasula, S.M., Ahmad, M., Lin, J.H., Poyet, J.L., Fernandes-Alnemri, T., Tsichlis, P.N., Alnemri, E.S., CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-κB activation and apoptosis (1999) J. Biol. Chem, 274, pp. 17946-17954
Koseki, T., Inohara, N., Chen, S., Carrio, R., Merino, J., Hottiger, M.O., Nabel, G.J., Nunez, G., CIPER, a novel NFκB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10 (1999) J. Biol. Chem, 274, pp. 9955-9961
Costanzo, A., Guiet, C., Vito, P., c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-κB (1999) J. Biol. Chem, 274, pp. 20127-20132
Ruland, J., Duncan, G.S., Elia, A., del Barco Barrantes, I., Nguyen, L., Plyte, S., Millar, D.G., Mak, T.W., Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure (2001) Cell, 104, pp. 33-42
Ruefli-Brasse, A.A., Lee, W.P., Hurst, S., Dixit, V.M., Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-κB activation (2004) J. Biol. Chem, 279, pp. 1570-1574
Bertin, J., Wang, L., Guo, Y., Jacobson, M.D., Poyet, J.L., Srinivasula, S.M., Merriam, S., Alnemri, E.S., CARD11 and CARD14 are novel caspase recruitment domain (CARD)/ membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-κ (2001) B. J. Biol. Chem, 276, pp. 11877-11882
Gaide, O., Martinon, F., Micheau, O., Bonnet, D., Thome, M., Tschopp, J., Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-κB activation (2001) FEBS Lett, 496, pp. 121-127
Pomerantz, J.L., Denny, E.M., Baltimore, D., CARD11 mediates factor-specific activation of NF-κB by the T cell receptor complex (2002) EMBO J, 21, pp. 5184-5194
McAllister-Lucas, L.M., Inohara, N., Lucas, P.C., Ruland, J., Benito, A., Li, Q., Chen, S., Verma, I.M., Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-κB induction (2001) J. Biol. Chem, 276, pp. 30589-30597
Wang, L., Guo, Y., Huang, W.J., Ke, X., Poyet, J.L., Manji, G.A., Merriam, S., Bertin, J., Card10 is a novel caspase recruitment domain/ membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-κB (2001) J. Biol. Chem, 276, pp. 21405-21409
Bertin, J., Guo, Y., Wang, L., Srinivasula, S.M., Jacobson, M.D., Poyet, J.L., Merriam, S., Robison, K.E., CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-κB (2000) J. Biol. Chem, 275, pp. 41082-41086
Gaide, O., Favier, B., Legler, D.F., Bonnet, D., Brissoni, B., Valitutti, S., Bron, C., Thome, M., CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-κB activation (2002) Nat. Immunol, 3, pp. 836-843
Hara, H., Wada, T., Bakal, C., Kozieradzki, I., Suzuki, S., Suzuki, N., Nghiem, M., Bauer, B., The MAGUK family protein CARD11 is essential for lymphocyte activation (2003) Immunity, 18, pp. 763-775
Wang, D., You, Y., Case, S.M., McAllister-Lucas, L.M., Wang, L., DiStefano, P.S., Nunez, G., Lin, X., A requirement for CARMA1 in TCR-induced NF-κB activation (2002) Nat. Immunol, 3, pp. 830-835
Stilo, R., Liguoro, D., Di Jeso, B., Formisano, S., Consiglio, E., Leonardi, A., Vito, P., Physical and functional interaction of CARMA1 and CARMA3 with Iκ kinase γ-NFκB essential modulator (2004) J. Biol. Chem, 279, pp. 34323-34331
Zhou, H., Wertz, I., O'Rourke, K., Ultsch, M., Seshagiri, S., Eby, M., Xiao, W., Dixit, V.M., Bcl10 activates the NF-κB pathway through ubiquitination of NEMO (2004) Nature, 427, pp. 167-171
Sun, L., Deng, L., Ea, C.K., Xia, Z.P., Chen, Z.J., The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes (2004) Mol. Cell, 14, pp. 289-301
Egawa, T., Albrecht, B., Favier, B., Sunshine, M.J., Mirchandani, K., O'Brien, W., Thome, M., Littman, D.R., Requirement for CARMA1 in antigen receptor-induced NF-κB activation and lymphocyte proliferation (2003) Curr. Biol, 13, pp. 1252-1258
Jun, J.E., Wilson, L.E., Vinuesa, C.G., Lesage, S., Blery, M., Miosge, L.A., Cook, M.C., Penninger, J.M., Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis (2003) Immunity, 18, pp. 751-762
Lenz, G., Davis, R.E., Ngo, V.N., Lam, L., George, T.C., Wright, G.W., Dave, S.S., Rosenwald, A., Oncogenic CARD11 mutations in human diffuse large B cell lymphoma (2008) Science, 319, pp. 1676-1679
Newton, K., Dixit, V.M., Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes (2003) Curr. Biol, 13, pp. 1247-1251
Grabiner, B.C., Blonska, M., Lin, P.C., You, Y., Wang, D., Sun, J., Darnay, B.G., Lin, X., CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-κB activation (2007) Genes Dev, 21, pp. 984-996
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res, 35, pp. 161-214
Stilo, R., Varricchio, E., Liguoro, D., Leonardi, A., Vito, P., A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-κB (2008) J. Cell Sci, 121, pp. 1165-1171
Tornatore, L., Marasco, D., Dathan, N., Vitale, R.M., Benedetti, E., Papa, S., Franzoso, G., Monti, S.M., Gadd45β forms a homodimeric complex that binds tightly to MKK7 (2008) J. Mol. Biol, 378, pp. 97-111
Stilo, R., Leonardi, A., Formisano, L., Di Jeso, B., Vito, P., Liguoro, D., TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-κB activation (2002) FEBS Lett, 521, pp. 165-169
Vaughn, D.E., Rodriguez, J., Lazebnik, Y., Joshua-Tor, L., Crystal structure of Apaf-1 caspase recruitment domain: An α-helical Greek key fold for apoptotic signaling (1999) J. Mol. Biol, 293, pp. 439-447
Richard, J.P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M.J., Chernomordik, L.V., Lebleu, B., Cell-penetrating peptides: A reevaluation of the mechanism of cellular uptake (2003) J. Biol. Chem, 278, pp. 585-590
Rebeaud, F., Hailfinger, S., Posevitz-Fejfar, A., Tapernoux, M., Moser, R., Rueda, D., Gaide, O., Rufer, N., The proteolytic activity of the paracaspase MALT1 is key in T cell activation (2008) Nat. Immunol, 9, pp. 272-281
Langel, F.D., Jain, N.A., Rossman, J.S., Kingeter, L.M., Kashyap, A.K., Schaefer, B.C., Multiple protein domains mediate interaction between BCL10 and MALT1 (2008) J. Biol. Chem, 283, pp. 32419-32431
Wan, F., Anderson, D.E., Barnitz, R.A., Snow, A., Bidere, N., Zheng, L., Hegde, V., Levens, D., Ribosomal protein S3: A KH domain subunit in NF-κB complexes that mediates selective gene regulation (2007) Cell, 131, pp. 927-939
Park, H. H., Lo, Y. C., Lin, S. C., Wang, L., Yang, J. K., Wu, H., The death domain superfamily in intracellular signaling of apoptosis and inflammation (2007) Annu. Rev. Immunol, 25, pp. 561-586
Willis, T. G., Jadayel, D. M., Du, M. Q., Peng, H., Perry, A. R., Abdul-Rauf, M., Price, H., Wlodarska, I., Bcl10 is involved in t (1
Srinivasula, S. M., Ahmad, M., Lin, J. H., Poyet, J. L., Fernandes-Alnemri, T., Tsichlis, P. N., Alnemri, E. S., CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF- B activation and apoptosis (1999) J. Biol. Chem, 274, pp. 17946-17954
Ruefli-Brasse, A. A., Lee, W. P., Hurst, S., Dixit, V. M., Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF- B activation (2004) J. Biol. Chem, 279, pp. 1570-1574
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Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation
The molecular complex containing BCL10 and CARMA [CARD (caspase recruitment domain)-containing MAGUK (membrane-associated guanylate kinase)] proteins has recently been identified as a key component in the signal transduction pathways that regulate activation of the transcription factor NF-κB (nuclear factor κB) in lymphoid and non-lymphoid cells. Assembly of complexes containing BCL10 and CARMA proteins relies on homophilic interactions established between the CARDs of these proteins. In order to identify BCL10-inhibitory peptides, we have established a method of assaying peptides derived from the CARD of BCL10 in binding competition assays of CARD-CARD self-association. By this procedure, a short peptide corresponding to amino acid residues 91-98 of BCL10 has been selected as an effective inhibitor of protein self-association. When tested in cell assays for its capacity to block NF-κB activation, this peptide represses activation of NF-κB mediated by BCL10, CARMA3 and PMA/ionomycin stimulation. Collectively, these results indicate that residues 91-98 of BCL10 are involved in BCL10 self-association and also participate in the interaction with external partners. We also show that blocking of the CARD of BCL10 may potentially be used for the treatment of pathological conditions associated with inappropriate NF-ΚB activation. © The Authors Journal compilation. © 2009 Biochemical Society.
The molecular complex containing BCL10 and CARMA [CARD (caspase recruitment domain)-containing MAGUK (membrane-associated guanylate kinase)] proteins has recently been identified as a key component in the signal transduction pathways that regulate activation of the transcription factor NF-κB (nuclear factor κB) in lymphoid and non-lymphoid cells. Assembly of complexes containing BCL10 and CARMA proteins relies on homophilic interactions established between the CARDs of these proteins. In order to identify BCL10-inhibitory peptides, we have established a method of assaying peptides derived from the CARD of BCL10 in binding competition assays of CARD-CARD self-association. By this procedure, a short peptide corresponding to amino acid residues 91-98 of BCL10 has been selected as an effective inhibitor of protein self-association. When tested in cell assays for its capacity to block NF-κB activation, this peptide represses activation of NF-κB mediated by BCL10, CARMA3 and PMA/ionomycin stimulation. Collectively, these results indicate that residues 91-98 of BCL10 are involved in BCL10 self-association and also participate in the interaction with external partners. We also show that blocking of the CARD of BCL10 may potentially be used for the treatment of pathological conditions associated with inappropriate NF-ΚB activation. © The Authors Journal compilation. © 2009 Biochemical Society.
Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation
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Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation
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Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
* The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (446 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533.
Impact Factor: 3.451
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1115 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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Zubrzak P, Banas A, Kaczmarek K, Leplawy MT, Sochacki M, Kowalski ML, Szkudlinska B, Zabrocki J, Di Lello P, Isernia C, Saviano M, Pedone C, Benedetti E
* Analogues of cyclolinopeptide A containing alpha-hydroxymethyl amino acid residues (469 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005; 80(2-3): 347-356.
Impact Factor: 2.425
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (431 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Benedetti E, Iacovino R, Pedone C, Rossi F, Saviano M, Isernia C, Montesarchio D, DeNapoli L, Piccialli G
β-Amino acid residues: Conformational characterization of an N- and C-protected homo-β-(S)-leucine (313 views)
Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1997 Jun; 4(3): 129-134.
Impact Factor: 0.557
View Export to BibTeX Export to EndNote
* The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (446 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533.
Impact Factor: 3.451
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1115 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Zubrzak P, Banas A, Kaczmarek K, Leplawy MT, Sochacki M, Kowalski ML, Szkudlinska B, Zabrocki J, Di Lello P, Isernia C, Saviano M, Pedone C, Benedetti E
* Analogues of cyclolinopeptide A containing alpha-hydroxymethyl amino acid residues (469 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005; 80(2-3): 347-356.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (431 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
View Export to BibTeX Export to EndNote
Benedetti E, Iacovino R, Pedone C, Rossi F, Saviano M, Isernia C, Montesarchio D, DeNapoli L, Piccialli G
β-Amino acid residues: Conformational characterization of an N- and C-protected homo-β-(S)-leucine (313 views)
Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1997 Jun; 4(3): 129-134.
Impact Factor: 0.557
View Export to BibTeX Export to EndNote
5 Records (5 excluding Abstracts).
Total impact factor: 14.758 (14.758 excluding Abstracts).
Total 5 year impact factor: 17.313 (17.313 excluding Abstracts).
Total impact factor: 14.758 (14.758 excluding Abstracts).
Total 5 year impact factor: 17.313 (17.313 excluding Abstracts).
522 views. Last view on Friday 31 March 2023, 5:56:02
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