Influence of risk factors on coronary flow reserve in patients with 1-vessel coronary artery disease(350 views) Vicario MLE, Cirillo L, Storto G, Pellegrino T, Ragone N, Fontanella L, Petretta M, Bonaduce D, Cuocolo A
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy
Institute of Biostructure and Bioimages, National Council of Research, Napoli, Italy
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Gould, K. L., Lipscomb, K., Effects of coronary stenosis on coronary flow reserve and resistance (1974) Am J Cardiol, 34, pp. 48-55
Pijls, N. H. J., Van Gelder, B., Van der Voort, P., Fractional flow reserve: A useful index to evaluate the influence of an epicardial coronary stenosis on myocardial blood flow (1995) Circulation, 92, pp. 3183-3193
Doucette, J. W., Corl, P. D., Payne, H. M., Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity (1992) Circulation, 85, pp. 1899-1911
Hau, W. K., Fractional flow reserve and complex coronary pathologic conditions (2004) Eur Heart J, 25, pp. 723-727
Bergman, S. R., Clinical applications of myocardial perfusion assessments made with oxygen-15 water and positron emission tomography (1997) Cardiology, 88, pp. 71-79
Pitkanen, O. P., Raitakari, O. T., Niinikoski, H., Coronary flow reserve is impaired in young men with familial hypercholesterolemia (1996) J Am Coll Cardiol, 28, pp. 1705-1711
Buus, N. H., Bottcher, M., Heimansen, F., Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia (2001) Circulation, 104, pp. 2305-2310
Gullberg, G. T., Di Bella, E. V., Sinusas, A. J., Estimation of coronary flow reserve: Can SPECT compete with other modalities? (2001) J Nucl Cardiol, 8, pp. 620-625
Di Caiii, M. F., Janisse, J., Grunberger, G., Role of chronic hyperglycemia in the pathogenesis of coronary micro vascular dysfunction in diabetes (2003) J Am Coll Cardiol, 41, pp. 1387-1393
Kaufmann, P. A., Gnecchi-Ruscone, T., di Terlizzi, M., Coronary heart disease in smokers: Vitamin C restores coronary microcirculatory function (2000) Circulation, 102, pp. 1233-1238
Uren, N. G., Melin, J. A., De Bruyne, B., Relation between myocardial blood flow and the severity of coronary-artery stenosis (1994) N Engl J Med, 330, pp. 1782-1788
Gould, K. L., Ornish, D., Scherwitz, L., Changes in myocardial perfusion abnormalities by positron emission tomography after long-term, intense risk factor modification (1995) JAMA, 274, pp. 894-901
Influence of risk factors on coronary flow reserve in patients with 1-vessel coronary artery disease
Coronary artery disease (CAD) risk factors influence the hyperemic response in patients without coronary artery stenosis. The aim of this study was to evaluate the influence of risk factors on coronary flow reserve (CFR) estimated by 99mTc-sestamibi cardiac imaging in patients with 1-vessel CAD. Methods: Forty-eight patients with 1-vessel CAD were enrolled in the study. Systemic hypertension, hypercholesterolemia, diabetes mellitus, and cigarette smoking were considered CAD risk factors. Within 48 h, all patients underwent coronary angiography and regional CFR assessment by 99mTc-sestamibi imaging with dipyridamole (0.74 mg/kg of body weight). Eight patients had no risk factors, 14 had 1 risk factor, 18 had 2 risk factors, and 8 had 3 risk factors. Results: The mean ± SD CFR of the narrowed coronary vessel was 1.28 ± 0.43 in the overall study population (1.52 ± 0.30 in patients with 50%-70% stenosis and 0.94 ± 0.75 in patients with >70% stenosis; P < 0.001). Two-factor ANOVA showed that the number of risk factors significantly affected CFR (P < 0.001) in patients with 50%-70% stenosis, whereas significance was only borderline in patients with >70% stenosis. Finally, a significant interaction among the degree of coronary artery stenosis, the number of risk factors, and the estimated CFR was found (F3 = 14.0; P < 0.001). Conclusion: CFR is inversely related to the number of conventional risk factors in patients with 1-vessel CAD and intermediate coronary artery stenosis, whereas this influence is less evident in patients with more severe stenosis.
Influence of risk factors on coronary flow reserve in patients with 1-vessel coronary artery disease
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(726 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote