Trehalose effects on alpha-crystallin aggregates (675 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 0006-291xlinking), 2007 Mar 23; 354(4): 899-905.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.749, 5-year impact factor: 2.802
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33846799235&partnerID=40&md5=3c58938e2d6a8e07a4109aa595ae3fa2
Keywords: α-Crystallin, Aggregates, Chaperone Activity, Thermal Stability, Trehalose, Alpha Crystallin, Article, Controlled Study, Human, Inhibition Kinetics, Priority Journal, Protein Aggregation, Protein Structure, Stress, Thermostability, Alpha-Crystallins, Circular Dichroism, Microscopy, Atomic Force, Quaternary, Spectrometry, Fluorescence, Thiazoles, Pharmacology, Chemistry, Drug Effects, Physiology,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini (IBB), CNR, Catania, Italy
Consorzio Catania Ricerche, Italy
Dipartimento di Scienze Chimiche, Università di Catania, Italy
Dipartimento di Chimica Fisica, Università di Palermo, Italy
References:
Bloemendal, H., (1981) Molecular and Cellular Biology of the Eye Lens, , Wiley, N
Horwitz, J., Alpha-crystallin can function as a molecular chaperone (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 10449-10453
Doss-Pepe, E.W., Carew, E.L., Koretz, J.F., Studies of the denaturation patterns of bovine alpha-crystallin using an ionic denaturant, guanidine hydrochloride and a non-ionic denaturant, urea (1998) Exp. Eye Res., 67, pp. 657-679
Spector, A., Li, L.K., Augusteyn, R.C., Schneider, A., Freund, T., Crystallin. The isolation and characterization of distinct macromolecular fractions (1971) Biochem. J., 124, pp. 337-343
Liang, J.J.-N., Akhtar, N.J., Human lens high-molecular-weight (α-crystallin aggregates (2000) Biochem. Biophys. Res. Commun., 275, pp. 354-359
Fujii, N., Awakura, M., Takemoto, L., Inomata, M., Tarata, T., Fujii, N., Saito, T., Characterization of αA-crystallin from high molecular weight aggregates in the normal human lens (2003) Mol. Vis., 9, pp. 315-322
Bindels, J., Siezen, R.J., Hoenders, H.J., The quaternary structure of bovine α-crystallin: effects of variations in alkaline pH, ionic strength, temperature and calcium ion concentration (1980) Eur. J. Biochem., 111, pp. 435-444
Thomson, J.A., Augusteyn, R.C., Alpha m-crystallin the native form of the protein? (1983) Exp. Eye Res., 37, pp. 367-377
Das, B.K., Liang, J.J.N., Chakrabarti, B., Heat-induced conformational change and increased chaperone activity of lens α-crystallin (1997) Curr. Eye Res., 16, pp. 303-309
Burgio, M.R., Carin, J.K., Dow, C.C., Koretz, J.F., Correlation between the chaperone-like activity and aggregate size of α-crystallin with increasing temperature (2000) Biochem. Biophys. Res. Commun., 268, pp. 426-432
Clauwaert, J., Ellerton, H.D., Koretz, J., Thomson, K., Augusteyn, R.C., The effect of temperature on the renaturation of α-crystallin (1989) Curr. Eye Res., 8, pp. 397-403
Takemoto, L., Boyle, D., The possible role of α-crystallins in human senile cararactogenesis (1998) Int. J. Biol. Macromol., 22, pp. 331-337
Meehan, S., Berry, Y., Luisi, B., Dobson, C.M., Carver, J.A., MacPhee, C.E., Amyloid fibril formation by lens crystalline proteins and its implications for cataract formation (2004) J. Biol. Chem., 279, pp. 3413-3419
Harding, J.J., Cataract, Alzheimer's disease, and other conformational diseases (1998) Curr. Opin. Ophthalmol., 9, pp. 10-13
Heon, E., Priston, M., Schorderet, D.F., Billingsley, G.D., Girard, P.O., Lubsen, N., Munier, F.L., The gamma-crystallins and human cataracts: a puzzle made clearer (1999) Am. J. Hum. Genet., 65, pp. 1261-1267
Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N.R., Doi, H., Kurosawa, M., Nukina, N., Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease (2004) Nat. Med., 10, pp. 148-154
Arora, A., Ha, C., Park, C.B., Inhibition of insulin amyloid formation by small stress molecules (2004) FEBS Lett., 564, pp. 121-125
Akashi, K., Miyake, C., Yokota, A., Citrulline, a novel compatible solute in drought-tolerant wild watermelon leaves, is an efficient hydroxyl radical scavenger (2001) FEBS Lett., 508, pp. 438-442
Yan, H., Harding, J.J., Carnosine inhibits modifications and decreased molecular chaperone activity of lens alpha-crystallin induced by ribose and fructose 6-phosphate (2006) Mol. Vis., 12, pp. 205-214
Arguelles, J.C., Physiological roles of trehalose in bacteria and yeasts: a comparative analysis (2000) Arch. Microbiol., 174, pp. 217-224
Benaroudj, N., Lee, D.H., Goldberg, A.L., Trehalose accumulation during cellular stress protects cells and cellular proteins from damage by oxygen radicals (2001) J. Biol. Chem., 276, pp. 24261-24267
Ganea, E., Harding, J.J., Trehalose and 6-aminohexanoic acid stabilize and renature glucose-6-phosphate dehydrogenase inactivated by glycation and by guanidinium hydrochloride (2005) J. Biol. Chem., 386, pp. 269-278
Liu, R., Barkhordarian, H., Emadi, S., Park, C.B., R Sierks, M., Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42 (2005) Neurobiol. Dis., 20, pp. 74-81
Davies, J.E., Sovan, S., Rubinsztein, D.C., Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy (2006) Hum. Mol. Genet., 15, pp. 23-31
Sharp, L.K., Mallya, M., Kinghorn, K.J., Wang, Z., Crowther, D.C., Huntington, J.A., Belorgey, D., Lomas, D.A., Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis (2006) FEBS J., 273, pp. 2540-2552
Naiki, H., Higuchi, K., Hosokawa, M., Takeda, T., Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavine T (1989) Anal. Biochem., 177, pp. 244-249
LeVine III, H., Quantification of beta-sheet amyloid fibril structures with thioflavin T (1999) Methods Enzymol., 309, pp. 274-284
Pignataro, B., Chi, L.F., Gao, S., Anczykowski, B., Niemeyer, C.M., Adler, M., Blohm, D., Fuchs, H., Dynamic scanning force microscopy study of self-assembled DNA-protein oligomers (2002) Appl. Phys. A, 74, pp. 447-452
Garcia, V.J., Martinez, L., Briceño-Valero, J.M., Shilling, C.M., (1997) Probe Microsc., 1, pp. 107-116
McFall-Ngai, M.J., Ding, L.L., Takemoto, L.J., Horwitz, J., Spatial and temporal mapping of the age-related changes in human lens crystallins (1985) Exp. Eye Res., 41, pp. 745-758
Spector, A., The search for a solution to senile cataracts (1984) Invest. Ophthalmol. Visual Sci., 25, pp. 130-146
Chiou, S.H., Azari, P.J., Physicochemical characterization of alpha-crystallins from bovine lenses: hydrodynamic and conformational properties (1989) Protein Chem., 8, pp. 1-17
Lee, J.S., Satoh, H.S., Samejima, T., Wu, S.H., Chiou, S.H., Effect of heat induced structural perturbation of secondary and tertiary structures on the chaperone activity of α-crystallin (1997) Biochem. Biophys. Res. Commun., 237, pp. 277-282
Liang, J.J.N., Sun, T.X., Akhtar, N.J., Heat-induced conformational change of human lens recombinant αA- and αB-crystallins (2000) Mol. Vis., 6, pp. 10-14
Beattie, G.M., Crowe, J.H., Lopez, A.D., Cirulli, V., Ricordi, C., Hayek, A., Trehalose: a cryoprotectant that enhances recovery and preserves function of human pancreatic islets after long-term storage (1997) Diabetes, 46, pp. 519-523
Beattie, G.M., Leibowitz, G., Lopez, A.D., Levine, F., Hayek, A., Protection from cell death in cultured human fetal pancreatic cells (2000) Cell Transplant., 9, pp. 431-438
Guo, N., Puhlev, I., Brown, D.R., Mansbridge, J., Levine, F., Trehalose expression confers desiccation tolerance on human cells (2000) Nat. Biotechnol., 18, pp. 168-171
Puhlev, I., Guo, N., Brown, D.R., Levine, F., Desiccation tolerance in human cells (2001) Cryobiology, 42, pp. 207-217
Mussauer, H., Sukhorukov, V.L., Zimmermann, U., Trehalose improves survival of electrotransfected mammalian cells (2001) Cytometry, 45, pp. 161-169
Reuss, R., Ludwig, J., Shirakashi, R., Ehrhart, F., Zimmermann, H., Schneider, S., Weber, M.M., Sukhorukov, V.L., Intracellular delivery of carbohydrates into mammalian cells through swelling-activated pathways (2004) J. Membr. Biol., 200, pp. 67-81
Wolkers, WF., Walker, N.J., Tablin, F., Crowe, J.H., Human platelets loaded with trehalose survive freeze-drying (2001) Cryobiology, 42, pp. 79-87
Wolkers, WF., Tablin, F., Crowe, J.H., From anhydrobiosis to freeze-drying of eukaryotic cells (2002) Physiol. A, 131, pp. 535-543
Nie, Y., de Pablo, J.J., Palecek, S.P., Platelet cryopreservation using a trehalose and phosphate formulation (2005) Biotechnol. Bioeng., 92, pp. 79-90
Erdag, G., Eroglu, A., Morgan, J.R., Toner, M., Cryopreservation of fetal skin is improved by extracellular trehalose (2002) Cryobiology, 44, pp. 218-228
Ji, L., de Pablo, J.J., Palecek, S.P., Cryopreservation of adherent human embryonic stem cells (2004) Biotechnol. Bioeng., 88, pp. 299-312
Satpathy, G.R., Torok, Z., Bali, R., Dwyre, D.M., Little, E., Wolkers, WF., Tablin, F., Tsvetkova, N.M., Loading red blood cells with trehalose: a step towards biostabilization (2004) Cryobiology, 49, pp. 123-136
Matsuo, T., Trehalose versus hyaluronan or cellulose in eyedrops for the treatment of dry eye (2004) Jpn. J. Ophthalmol., 48, pp. 321-327
Matsuo, T., Tsuchida, Y., Morimoto, N., Trehalose eye drops in the treatment of dry eye syndrome (2002) Ophthalmology, 109, pp. 2024-2029
Steadman, B.L., Trautman, P.A., Lawson, E.Q., Raymond, M.J., Mood, D.A., Thomson, J.A., Middaugh, C.R., A differential scanning calorimetric study of the bovine lens crystallins (1989) Biochemistry, 28, pp. 9653-9658
Walsh, M.T., Sen, A.C., Chakrabarti, B., Micellar subunit assembly in a three-layer model of oligomeric alpha-crystallin (1991) J. Biol. Chem., 266, pp. 20079-20084
Surewicz, W.K., Olesen, P.R., On the thermal stability of alpha-crystallin: a new insight from infrared spectroscopy (1995) Biochemistry, 34, pp. 9655-9660
Gesierich, U., Pfeil, W., The conformational stability of alpha-crystallin is rather low: calorimetric results (1996) FEBS Lett., 393, pp. 151-154
Arakawa, T., Timasheff, S.N., Stabilization of protein structure by sugars (1982) Biochemistry, 21, pp. 6536-6544
Xie, G., Timasheff, S.N., The thermodynamic mechanism of protein stabilization by trehalose (1997) Biophys. Chem., 64, pp. 25-43
Timasheff, S.N., Protein-solvent preferential interactions, protein hydration, and the modulation of biochemical reactions by solvent components (2002) Proc. Natl. Acad. Sci., 99, pp. 9721-9726
Kaushik, J.K., Bhat, R., Why is trehalose an exceptional protein stabilizer? An analysis of the thermal stability of proteins in the presence of the compatible osmolyte trehalose (2003) J. Biol. Chem., 278, pp. 26458-26465
Lins, R.D., Pereira, C.S., Hünenberger, P.H., Trehalose-protein interaction in aqueous solution (2004) Proteins, 55, pp. 177-186
Cesaro, A., Magazù, V., Migliardo, F., Sussich, F., Vadalà, M., (2004) Physica B: Condensed Matter, 350 (1-3 SUPPL.1), pp. e367-e370
Hédoux, A., Willart, J.F., Ionov, R., Affouard, F., Guinet, Y., Paccou, L., Lerbret, A., Descamps, M.J., Analysis of sugar bioprotective mechanisms on the thermal denaturation of lysozyme from Raman scattering and differential scanning calorimetry investigations (2006) Phys. Chem. B, 110, pp. 22886-22893
Magazù, S., Migliardo, F., Ramirez-Cuesta, A.J., Study on physical mechanisms of bioprotection (2006) Int. J. Phys. Sci., 1, pp. 75-80
Choi, Y., Cho, K.W., Jeong, K., Jung, S., Molecular dynamics simulations of trehalose as a 'dynamic reducer' for solvent water molecules in the hydration shell (2006) Carbohydr. Res., 341, pp. 1020-1028
Doss-Pepe, E. W., Carew, E. L., Koretz, J. F., Studies of the denaturation patterns of bovine alpha-crystallin using an ionic denaturant, guanidine hydrochloride and a non-ionic denaturant, urea (1998) Exp. Eye Res., 67, pp. 657-679
Liang, J. J. -N., Akhtar, N. J., Human lens high-molecular-weight (-crystallin aggregates (2000) Biochem. Biophys. Res. Commun., 275, pp. 354-359
Thomson, J. A., Augusteyn, R. C., Alpha m-crystallin the native form of the protein? (1983) Exp. Eye Res., 37, pp. 367-377
Das, B. K., Liang, J. J. N., Chakrabarti, B., Heat-induced conformational change and increased chaperone activity of lens -crystallin (1997) Curr. Eye Res., 16, pp. 303-309
Burgio, M. R., Carin, J. K., Dow, C. C., Koretz, J. F., Correlation between the chaperone-like activity and aggregate size of -crystallin with increasing temperature (2000) Biochem. Biophys. Res. Commun., 268, pp. 426-432
Harding, J. J., Cataract, Alzheimer's disease, and other conformational diseases (1998) Curr. Opin. Ophthalmol., 9, pp. 10-13
Arguelles, J. C., Physiological roles of trehalose in bacteria and yeasts: a comparative analysis (2000) Arch. Microbiol., 174, pp. 217-224
Davies, J. E., Sovan, S., Rubinsztein, D. C., Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy (2006) Hum. Mol. Genet., 15, pp. 23-31
Sharp, L. K., Mallya, M., Kinghorn, K. J., Wang, Z., Crowther, D. C., Huntington, J. A., Belorgey, D., Lomas, D. A., Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis (2006) FEBS J., 273, pp. 2540-2552
Garcia, V. J., Martinez, L., Brice o-Valero, J. M., Shilling, C. M., (1997) Probe Microsc., 1, pp. 107-116
McFall-Ngai, M. J., Ding, L. L., Takemoto, L. J., Horwitz, J., Spatial and temporal mapping of the age-related changes in human lens crystallins (1985) Exp. Eye Res., 41, pp. 745-758
Chiou, S. H., Azari, P. J., Physicochemical characterization of alpha-crystallins from bovine lenses: hydrodynamic and conformational properties (1989) Protein Chem., 8, pp. 1-17
Lee, J. S., Satoh, H. S., Samejima, T., Wu, S. H., Chiou, S. H., Effect of heat induced structural perturbation of secondary and tertiary structures on the chaperone activity of -crystallin (1997) Biochem. Biophys. Res. Commun., 237, pp. 277-282
Liang, J. J. N., Sun, T. X., Akhtar, N. J., Heat-induced conformational change of human lens recombinant A- and B-crystallins (2000) Mol. Vis., 6, pp. 10-14
Beattie, G. M., Crowe, J. H., Lopez, A. D., Cirulli, V., Ricordi, C., Hayek, A., Trehalose: a cryoprotectant that enhances recovery and preserves function of human pancreatic islets after long-term storage (1997) Diabetes, 46, pp. 519-523
Beattie, G. M., Leibowitz, G., Lopez, A. D., Levine, F., Hayek, A., Protection from cell death in cultured human fetal pancreatic cells (2000) Cell Transplant., 9, pp. 431-438
Satpathy, G. R., Torok, Z., Bali, R., Dwyre, D. M., Little, E., Wolkers, WF., Tablin, F., Tsvetkova, N. M., Loading red blood cells with trehalose: a step towards biostabilization (2004) Cryobiology, 49, pp. 123-136
Steadman, B. L., Trautman, P. A., Lawson, E. Q., Raymond, M. J., Mood, D. A., Thomson, J. A., Middaugh, C. R., A differential scanning calorimetric study of the bovine lens crystallins (1989) Biochemistry, 28, pp. 9653-9658
Walsh, M. T., Sen, A. C., Chakrabarti, B., Micellar subunit assembly in a three-layer model of oligomeric alpha-crystallin (1991) J. Biol. Chem., 266, pp. 20079-20084
Surewicz, W. K., Olesen, P. R., On the thermal stability of alpha-crystallin: a new insight from infrared spectroscopy (1995) Biochemistry, 34, pp. 9655-9660
Timasheff, S. N., Protein-solvent preferential interactions, protein hydration, and the modulation of biochemical reactions by solvent components (2002) Proc. Natl. Acad. Sci., 99, pp. 9721-9726
Kaushik, J. K., Bhat, R., Why is trehalose an exceptional protein stabilizer? An analysis of the thermal stability of proteins in the presence of the compatible osmolyte trehalose (2003) J. Biol. Chem., 278, pp. 26458-26465
Lins, R. D., Pereira, C. S., H nenberger, P. H., Trehalose-protein interaction in aqueous solution (2004) Proteins, 55, pp. 177-186
Cesaro, A., Magaz, V., Migliardo, F., Sussich, F., Vadal, M., (2004) Physica B: Condensed Matter, 350 (1-3 SUPPL. 1), pp. e367-e370
H doux, A., Willart, J. F., Ionov, R., Affouard, F., Guinet, Y., Paccou, L., Lerbret, A., Descamps, M. J., Analysis of sugar bioprotective mechanisms on the thermal denaturation of lysozyme from Raman scattering and differential scanning calorimetry investigations (2006) Phys. Chem. B, 110, pp. 22886-22893
Magaz, S., Migliardo, F., Ramirez-Cuesta, A. J., Study on physical mechanisms of bioprotection (2006) Int. J. Phys. Sci., 1, pp. 75-80
Choi, Y., Cho, K. W., Jeong, K., Jung, S., Molecular dynamics simulations of trehalose as a 'dynamic reducer' for solvent water molecules in the hydration shell (2006) Carbohydr. Res., 341, pp. 1020-1028
Biochem Biophys Res Commun (ISSN: 0006-291x, 0006-291xlinking), 2007 Mar 23; 354(4): 899-905.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.749, 5-year impact factor: 2.802
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33846799235&partnerID=40&md5=3c58938e2d6a8e07a4109aa595ae3fa2
Keywords: α-Crystallin, Aggregates, Chaperone Activity, Thermal Stability, Trehalose, Alpha Crystallin, Article, Controlled Study, Human, Inhibition Kinetics, Priority Journal, Protein Aggregation, Protein Structure, Stress, Thermostability, Alpha-Crystallins, Circular Dichroism, Microscopy, Atomic Force, Quaternary, Spectrometry, Fluorescence, Thiazoles, Pharmacology, Chemistry, Drug Effects, Physiology,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini (IBB), CNR, Catania, Italy
Consorzio Catania Ricerche, Italy
Dipartimento di Scienze Chimiche, Università di Catania, Italy
Dipartimento di Chimica Fisica, Università di Palermo, Italy
References:
Bloemendal, H., (1981) Molecular and Cellular Biology of the Eye Lens, , Wiley, N
Horwitz, J., Alpha-crystallin can function as a molecular chaperone (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 10449-10453
Doss-Pepe, E.W., Carew, E.L., Koretz, J.F., Studies of the denaturation patterns of bovine alpha-crystallin using an ionic denaturant, guanidine hydrochloride and a non-ionic denaturant, urea (1998) Exp. Eye Res., 67, pp. 657-679
Spector, A., Li, L.K., Augusteyn, R.C., Schneider, A., Freund, T., Crystallin. The isolation and characterization of distinct macromolecular fractions (1971) Biochem. J., 124, pp. 337-343
Liang, J.J.-N., Akhtar, N.J., Human lens high-molecular-weight (α-crystallin aggregates (2000) Biochem. Biophys. Res. Commun., 275, pp. 354-359
Fujii, N., Awakura, M., Takemoto, L., Inomata, M., Tarata, T., Fujii, N., Saito, T., Characterization of αA-crystallin from high molecular weight aggregates in the normal human lens (2003) Mol. Vis., 9, pp. 315-322
Bindels, J., Siezen, R.J., Hoenders, H.J., The quaternary structure of bovine α-crystallin: effects of variations in alkaline pH, ionic strength, temperature and calcium ion concentration (1980) Eur. J. Biochem., 111, pp. 435-444
Thomson, J.A., Augusteyn, R.C., Alpha m-crystallin the native form of the protein? (1983) Exp. Eye Res., 37, pp. 367-377
Das, B.K., Liang, J.J.N., Chakrabarti, B., Heat-induced conformational change and increased chaperone activity of lens α-crystallin (1997) Curr. Eye Res., 16, pp. 303-309
Burgio, M.R., Carin, J.K., Dow, C.C., Koretz, J.F., Correlation between the chaperone-like activity and aggregate size of α-crystallin with increasing temperature (2000) Biochem. Biophys. Res. Commun., 268, pp. 426-432
Clauwaert, J., Ellerton, H.D., Koretz, J., Thomson, K., Augusteyn, R.C., The effect of temperature on the renaturation of α-crystallin (1989) Curr. Eye Res., 8, pp. 397-403
Takemoto, L., Boyle, D., The possible role of α-crystallins in human senile cararactogenesis (1998) Int. J. Biol. Macromol., 22, pp. 331-337
Meehan, S., Berry, Y., Luisi, B., Dobson, C.M., Carver, J.A., MacPhee, C.E., Amyloid fibril formation by lens crystalline proteins and its implications for cataract formation (2004) J. Biol. Chem., 279, pp. 3413-3419
Harding, J.J., Cataract, Alzheimer's disease, and other conformational diseases (1998) Curr. Opin. Ophthalmol., 9, pp. 10-13
Heon, E., Priston, M., Schorderet, D.F., Billingsley, G.D., Girard, P.O., Lubsen, N., Munier, F.L., The gamma-crystallins and human cataracts: a puzzle made clearer (1999) Am. J. Hum. Genet., 65, pp. 1261-1267
Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N.R., Doi, H., Kurosawa, M., Nukina, N., Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease (2004) Nat. Med., 10, pp. 148-154
Arora, A., Ha, C., Park, C.B., Inhibition of insulin amyloid formation by small stress molecules (2004) FEBS Lett., 564, pp. 121-125
Akashi, K., Miyake, C., Yokota, A., Citrulline, a novel compatible solute in drought-tolerant wild watermelon leaves, is an efficient hydroxyl radical scavenger (2001) FEBS Lett., 508, pp. 438-442
Yan, H., Harding, J.J., Carnosine inhibits modifications and decreased molecular chaperone activity of lens alpha-crystallin induced by ribose and fructose 6-phosphate (2006) Mol. Vis., 12, pp. 205-214
Arguelles, J.C., Physiological roles of trehalose in bacteria and yeasts: a comparative analysis (2000) Arch. Microbiol., 174, pp. 217-224
Benaroudj, N., Lee, D.H., Goldberg, A.L., Trehalose accumulation during cellular stress protects cells and cellular proteins from damage by oxygen radicals (2001) J. Biol. Chem., 276, pp. 24261-24267
Ganea, E., Harding, J.J., Trehalose and 6-aminohexanoic acid stabilize and renature glucose-6-phosphate dehydrogenase inactivated by glycation and by guanidinium hydrochloride (2005) J. Biol. Chem., 386, pp. 269-278
Liu, R., Barkhordarian, H., Emadi, S., Park, C.B., R Sierks, M., Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42 (2005) Neurobiol. Dis., 20, pp. 74-81
Davies, J.E., Sovan, S., Rubinsztein, D.C., Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy (2006) Hum. Mol. Genet., 15, pp. 23-31
Sharp, L.K., Mallya, M., Kinghorn, K.J., Wang, Z., Crowther, D.C., Huntington, J.A., Belorgey, D., Lomas, D.A., Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis (2006) FEBS J., 273, pp. 2540-2552
Naiki, H., Higuchi, K., Hosokawa, M., Takeda, T., Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavine T (1989) Anal. Biochem., 177, pp. 244-249
LeVine III, H., Quantification of beta-sheet amyloid fibril structures with thioflavin T (1999) Methods Enzymol., 309, pp. 274-284
Pignataro, B., Chi, L.F., Gao, S., Anczykowski, B., Niemeyer, C.M., Adler, M., Blohm, D., Fuchs, H., Dynamic scanning force microscopy study of self-assembled DNA-protein oligomers (2002) Appl. Phys. A, 74, pp. 447-452
Garcia, V.J., Martinez, L., Briceño-Valero, J.M., Shilling, C.M., (1997) Probe Microsc., 1, pp. 107-116
McFall-Ngai, M.J., Ding, L.L., Takemoto, L.J., Horwitz, J., Spatial and temporal mapping of the age-related changes in human lens crystallins (1985) Exp. Eye Res., 41, pp. 745-758
Spector, A., The search for a solution to senile cataracts (1984) Invest. Ophthalmol. Visual Sci., 25, pp. 130-146
Chiou, S.H., Azari, P.J., Physicochemical characterization of alpha-crystallins from bovine lenses: hydrodynamic and conformational properties (1989) Protein Chem., 8, pp. 1-17
Lee, J.S., Satoh, H.S., Samejima, T., Wu, S.H., Chiou, S.H., Effect of heat induced structural perturbation of secondary and tertiary structures on the chaperone activity of α-crystallin (1997) Biochem. Biophys. Res. Commun., 237, pp. 277-282
Liang, J.J.N., Sun, T.X., Akhtar, N.J., Heat-induced conformational change of human lens recombinant αA- and αB-crystallins (2000) Mol. Vis., 6, pp. 10-14
Beattie, G.M., Crowe, J.H., Lopez, A.D., Cirulli, V., Ricordi, C., Hayek, A., Trehalose: a cryoprotectant that enhances recovery and preserves function of human pancreatic islets after long-term storage (1997) Diabetes, 46, pp. 519-523
Beattie, G.M., Leibowitz, G., Lopez, A.D., Levine, F., Hayek, A., Protection from cell death in cultured human fetal pancreatic cells (2000) Cell Transplant., 9, pp. 431-438
Guo, N., Puhlev, I., Brown, D.R., Mansbridge, J., Levine, F., Trehalose expression confers desiccation tolerance on human cells (2000) Nat. Biotechnol., 18, pp. 168-171
Puhlev, I., Guo, N., Brown, D.R., Levine, F., Desiccation tolerance in human cells (2001) Cryobiology, 42, pp. 207-217
Mussauer, H., Sukhorukov, V.L., Zimmermann, U., Trehalose improves survival of electrotransfected mammalian cells (2001) Cytometry, 45, pp. 161-169
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Magaz, S., Migliardo, F., Ramirez-Cuesta, A. J., Study on physical mechanisms of bioprotection (2006) Int. J. Phys. Sci., 1, pp. 75-80
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Trehalose effects on alpha-crystallin aggregates
alpha-Crystallin in its native state is a large, heterogeneous, low-molecular weight (LMW) aggregate that under certain conditions may progressively became part of insoluble high-molecular weight (HMW) systems. These systems are supposed to play a relevant role in eye lens opacification and vision impairment. In this paper, we report the effects of trehalose on alpha-crystallin aggregates. The role of trehalose in alpha-crystallin stress tolerance, chaperone activity and thermal stability is studied. The results show that trehalose stabilizes the alpha-crystallin native structure, inhibits alpha-crystallin aggregation, and disaggregates preformed LMW systems not affecting its chaperone activity. (c) 2007 Elsevier Inc. All rights reserved
alpha-Crystallin in its native state is a large, heterogeneous, low-molecular weight (LMW) aggregate that under certain conditions may progressively became part of insoluble high-molecular weight (HMW) systems. These systems are supposed to play a relevant role in eye lens opacification and vision impairment. In this paper, we report the effects of trehalose on alpha-crystallin aggregates. The role of trehalose in alpha-crystallin stress tolerance, chaperone activity and thermal stability is studied. The results show that trehalose stabilizes the alpha-crystallin native structure, inhibits alpha-crystallin aggregation, and disaggregates preformed LMW systems not affecting its chaperone activity. (c) 2007 Elsevier Inc. All rights reserved
Trehalose effects on alpha-crystallin aggregates
| ▼ Characterization of neurotoxic and neuroprotective factors by using computational methodologies |
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Trehalose effects on alpha-crystallin aggregates
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J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (664 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (638 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
Impact Factor: 2.648
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (429 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (258 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (392 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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Randazzo R, Mammana A, D'Urso A, Lauceri R, Purrello R
* Reversible "chiral memory" in ruthenium tris(phenanthroline)- anionic porphyrin complexes (402 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2008; 47(51): 9879-9882.
Impact Factor: 10.879
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2008; 14(14): 4164-4166.
Impact Factor: 5.454
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (575 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (606 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Sciacca MFM, Milardi D, Pappalardo M, La Rosa C, Grasso DM
* Role of electrostatics in the thermal stability of ubiquitin: A combined DSC and MM study (248 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2006 Nov; 86(2): 311-314.
Impact Factor: 1.438
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (442 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Angela M, Massimo De N, Rosaria L, Roberto P
* Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (417 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
Impact Factor: 2.286
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Bucci E, Vitagliano L, Barone R, Sorrentino S, D'Alessio G, Graziano G
* On the thermal stability of the two dimeric forms of ribonuclease (451 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2005 Jul 1; 116(2): 89-95.
Impact Factor: 1.925
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Lauceria R, Purrellob R
* Transfer, memory and amplification of chirality in porphyrin aggregates (303 views)
Supramol Chem (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
Impact Factor: 1.715
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (422 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (719 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004 May 25; 43(20): 6043-6058.
Impact Factor: 4.008
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (462 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Pedone E, Bartolucci S, Rossi M, Pierfederici FM, Scire A, Cacciamani T, Tanfani F
* Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study (548 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2003 Sep 1; 373: 875-883.
Impact Factor: 4.101
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Moschetto A, Lauceri R, Gulino FG, Sciotto D, Purrello R
* Non-covalent synthesis in aqueous solution of discrete multi-porphyrin aggregates with programmable stoichiometry and sequence (564 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Dec 11; 124(49): 14536-14537.
Impact Factor: 6.201
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Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
* From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (770 views)
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
Impact Factor: 9.023
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* The introduction of a cysteine residue modulates the mechanical properties of aromatic-based solid aggregates and self-supporting hydrogels (22 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2021 Oct 25; 27(60): 14886-14898.
Impact Factor: 5.236
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Smaldone G, Caruso D, Sandomenico A, Iaccarino E, Focà A, Ruggiero A, Ruvo M, Vitagliano L
* Members of the GADD45 Protein Family Show Distinct Propensities to form Toxic Amyloid-Like Aggregates in Physiological Conditions (19 views)
Int J Mol Sci (ISSN: 1422-0067linking), 2021 Oct 2; 22 (19 ): N/D-N/D.
Impact Factor:
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Monti A, Bruckmann C, Blasi F, Ruvo M, Vitagliano L, Doti N
* Amyloid-like Prep1 peptides exhibit reversible blue-green-red fluorescence in vitro and in living cells (24 views)
Chem Commun (ISSN: 1359-7345linking, 1364-548xelectronic), 2021 Apr 18; 57(30): 3720-3723.
Impact Factor: 5.996
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Balasco N, Diaferia C, Morelli G, Vitagliano L, Accardo A
* Amyloid-Like Aggregation in Diseases and Biomaterials: Osmosis of Structural Information (21 views)
Front Bioeng Biotechnol (ISSN: 2296-4185linking), 2021 Mar 3; 9: 641372-641372.
Impact Factor: 5.48
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Marasco D, Vicidomini C, Krupa P, Cioffi F, Pham DQH, Li MS, Florio D, Broersen K, De Pandis MF, Roviello GN
* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
Impact Factor: 5.192
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Di Natale C, La Manna S, Avitabile C, Florio D, Morelli G, Netti PA, Marasco D
* Corrigendum to "Engineered β-hairpin scaffolds from human prion protein regions: Structural and functional investigations of aggregates" [Bioorg. Chem. 96 (2020) 103594] (36 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2020 Jun; 99: 103853-103853.
Impact Factor: 3.119
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Di Natale C, La Manna S, Avitabile C, Florio D, Morelli G, Netti PA, Marasco D
* Engineered β-hairpin scaffolds from human prion protein regions: Structural and functional investigations of aggregates (58 views)
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Impact Factor: 4.831
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Avitabile C, Diaferia C, Roviello V, Altamura D, Giannini C, Vitagliano L, Accardo A, Romanelli A
* Fluorescence and Morphology of Self-Assembled Nucleobases and Their Diphenylalanine Hybrid Aggregates (232 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2019 Nov 22; 25(65): 14850-14857.
Impact Factor: 5.476
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Ruggiero A, Smaldone G, Esposito L, Balasco N, Vitagliano L
* Loop size optimization induces a strong thermal stabilization of the thioredoxin fold (193 views)
Febs J (ISSN: 1742-464xlinking), 2019 May; 286(9): 1752-1764.
Impact Factor: 3.129
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Balasco N, Barone D, Iaccarino E, Sandomenico A, De Simone A, Ruvo M, Vitagliano L
* Intrinsic structural versatility of the highly conserved 412-423 epitope of the Hepatitis C Virus E2 protein (269 views)
Int J Biol Macromol (ISSN: 1879-0003electronic, 0141-8130linking), 2018 Sep; 116: 620-632.
Impact Factor: 1.427
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Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
* Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates (891 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Impact Factor: 5.476
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (202 views)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
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Galati C, Spinella N, Renna L, Milardi D, Attanasio F, Sciacca MFM, Bongiorno C
* Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology (412 views)
Beilstein J Nanotech (ISSN: 2190-4286), 2017 Nov 20; 8(1): 2446-2453.
Impact Factor: 2.968
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Grasso GI, Bellia F, Arena G, Satriano C, Vecchio G, Rizzarelli E
* Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity (417 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jul 28; 135: 447-457.
Impact Factor: 4.816
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Smaldone G, Pirone L, Pedone E, Marlovits T, Vitagliano L, Ciccarelli L
* The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states (248 views) (PDF 43 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468), 2016 Jun; 590(11): 1663-1671.
Impact Factor: 3.623
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Ruvo M, Doti N, Lorenzo V, Vitagliano L, Mascanzoni F
* The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability (280 views)
Mol Biotechnol (ISSN: 1073-6085, 1559-0305electronic, 1073-6085linking), 2016 May; 58(5): 328-339.
Impact Factor: 1.634
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Di Natale C, Scognamiglio PL, Cascella R, Cecchi C, Russo A, Leone M, Penco A, Relini A, Federici L, Di Matteo A, Chiti F, Vitagliano L, Marasco D
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The Faseb Journal (ISSN: 1530-6860, 1530-6860electronic), 2015 Sep; 29(9): 3689-3701.
Impact Factor: 5.043
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (527 views)
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Impact Factor: 2.963
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Sinopoli A, Magri A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, GrassoG
* The role of copper(II) in the aggregation of human amylin (492 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014 Oct; 6(10): 1841-1852.
Impact Factor: 3.585
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (471 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Accardo A, Ringhieri P, Palumbo R, Morelli G
* Influence of PEG length on conformational and binding properties of CCK peptides exposed by supramolecular aggregates (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Apr; 101(4): 304-312.
Impact Factor: 2.385
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (707 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F
* Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability (642 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1844(3): 632-640.
Impact Factor: 4.882
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Villari V, Attanasio F, Micali N
* Control of the structural stability of α-crystallin under thermal and chemical stress: The role of carnosine (415 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207linking), 2014; 118(47): 13770-13776.
Impact Factor: 3.302
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Del Giudice I, Limauro D, Pedone E, Bartolucci S, Fiorentino G
* A novel arsenate reductase from the bacterium Thermus thermophilus HB27: Its role in arsenic detoxification (422 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Oct; 1834(10): 2071-2079.
Impact Factor: 3.191
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Pica A, Merlino A, Buell AK, Knowles TJ, Pizzo E, D'Alessio G, Sica F, Mazzarella L
* Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase (1008 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Oct; 69: 2116-2123.
Impact Factor: 7.232
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (410 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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Hunger K, Buschhaus L, Biemann L, Braun M, Kovalenko S, Improta R, Kleinermanns K
* UV-light-induced hydrogen transfer in guanosine-guanosine aggregates (431 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Apr; 19(17): 5425-5431.
Impact Factor: 5.696
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Marasco D, Ruggiero A, Vascotto C, Poletto M, Scognamiglio PL, Tell G, Vitagliano L
* Role of mutual interactions in the chemical and thermal stability of nucleophosmin NPM1 domains (326 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x), 2013 Jan 11; 430(2): 523-528.
Impact Factor: 2.281
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Merlino A, Russo Krauss I, Rossi B, De Vendittis A, Marco S, De Vendittis E, Vergara A, Sica F
* Identification of an active dimeric intermediate populated during the unfolding process of the cambialistic superoxide dismutase from Streptococcus mutans (358 views)
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Impact Factor: 3.142
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Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (595 views)
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Impact Factor: 5.925
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (609 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (509 views)
Mol Biosyst (ISSN: 1742-206x), 2011 Mar; 7(3): 862-870.
Impact Factor: 3.534
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Merlino A, Russo Krauss I, Castellano I, De Vendittis E, Rossi B, Conte M, Vergara A, Sica F
* Structure and flexibility in cold-adapted iron superoxide dismutases: The case of the enzyme isolated from Pseudoalteromonas haloplanktis (543 views)
J Struct Biol (ISSN: 1047-8477, 1047-8477linking), 2010 Dec; 172(3): 343-352.
Impact Factor: 3.5
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Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (507 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (600 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (367 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (431 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (664 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (638 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
Impact Factor: 2.648
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (429 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (258 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (392 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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Randazzo R, Mammana A, D'Urso A, Lauceri R, Purrello R
* Reversible "chiral memory" in ruthenium tris(phenanthroline)- anionic porphyrin complexes (402 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2008; 47(51): 9879-9882.
Impact Factor: 10.879
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2008; 14(14): 4164-4166.
Impact Factor: 5.454
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (575 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (606 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Sciacca MFM, Milardi D, Pappalardo M, La Rosa C, Grasso DM
* Role of electrostatics in the thermal stability of ubiquitin: A combined DSC and MM study (248 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2006 Nov; 86(2): 311-314.
Impact Factor: 1.438
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (442 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Angela M, Massimo De N, Rosaria L, Roberto P
* Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (417 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
Impact Factor: 2.286
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Bucci E, Vitagliano L, Barone R, Sorrentino S, D'Alessio G, Graziano G
* On the thermal stability of the two dimeric forms of ribonuclease (451 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2005 Jul 1; 116(2): 89-95.
Impact Factor: 1.925
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Lauceria R, Purrellob R
* Transfer, memory and amplification of chirality in porphyrin aggregates (303 views)
Supramol Chem (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
Impact Factor: 1.715
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Merlino A, Graziano G, Mazzarella L
* Structural And Dynamic Effects Of Alpha-Helix Deletion In Sso7d: Implications For Protein Thermal Stability (422 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2004 Dec 1; 57(4): 692-701.
Impact Factor: 4.429
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Leone M, Di Lello P, Ohlenschläger O, Pedone E, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R
* Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability (719 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004 May 25; 43(20): 6043-6058.
Impact Factor: 4.008
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (462 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Pedone E, Bartolucci S, Rossi M, Pierfederici FM, Scire A, Cacciamani T, Tanfani F
* Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study (548 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2003 Sep 1; 373: 875-883.
Impact Factor: 4.101
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Moschetto A, Lauceri R, Gulino FG, Sciotto D, Purrello R
* Non-covalent synthesis in aqueous solution of discrete multi-porphyrin aggregates with programmable stoichiometry and sequence (564 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Dec 11; 124(49): 14536-14537.
Impact Factor: 6.201
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Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
* From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (770 views)
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
Impact Factor: 9.023
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64 Records (62 excluding Abstracts).
Total impact factor: 245.176 (243.522 excluding Abstracts).
Total 5 year impact factor: 256.459 (254.677 excluding Abstracts).
Total impact factor: 245.176 (243.522 excluding Abstracts).
Total 5 year impact factor: 256.459 (254.677 excluding Abstracts).
675 views. Last view on Wednesday 31 May 2023, 23:16:41
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