Keywords: Cardiac-Gated Imaging Techniques, Diabetes Mellitus, Prognosis, Cardiovascular Risk, Clinical Evaluation, Computer Assisted Tomography, Coronary Artery Disease, Diagnostic Accuracy, Heart Catheterization, Heart Scintiscanning, Human, Nuclear Magnetic Resonance Imaging, Quality Of Life, Review, Risk Assessment, Risk Factor, Screening, Single Photon Emission Computer Tomography, Stress Echocardiography, Cardiovascular Disease, Diabetic Angiopathy, Prediction And Forecasting, Diabetic Angiopathies, Predictive Value Of Tests,
Affiliations: *** IBB - CNR ***
Department of Biomorphological and Functional Sciences, University Federico II, Via Pansini 5, 80131 Naples, Italy
Institute of Biostructures and Bioimages, National Council of Research, Naples, Italy
SDN Foundation, Institute of Diagnostic and Nuclear Development, Naples, Italy
Department of Clinical Medicine Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy
References: Mokdad, A.H., Ford, E.S., Bowman, B.A., Nelson, D.E., Engelgau, M.M., Vinicor, F., Diabetes trends in the US: 1990-1998 (2000) Diabetes Care, 23, pp. 1278-128
Wild, S., Roglic, G., Green, A., Sicree, R., King, H., Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030 (2004) Diabetes Care, 27, pp. 1047-1053
Conquering Diabetes: A Strategic Plan for the 21st Century, , Diabetes Research Working Group Bethesda, Md: National Institutes of Health
1999. NIH publication No. 99-4398
De Backer, G., Ambrosioni, E., Borch-Johnsen, K., Brotons, C., Cifkova, R., Dallongeville, J., Ebrahim, S., Wood, D., European guidelines on cardiovascular disease prevention in clinical practice: Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of eight societies and by invited experts) (2003) European Journal of Cardiovascular Prevention and Rehabilitation, 10 (SUPPL. 1), pp. S1-S78
Morrish, N.J., Wang, S.-L., Stevens, L.K., Fuller, J.H., Keen, H., Lee, E.T., Lu, M., Bennett, P.H., Mortality and causes of death in the WHO multinational study of vascular disease in diabetes (2001) Diabetologia, 44 (SUPPL. 2), pp. S14-S21
Jacoby, R.M., Nesto, R.W., Acute myocardial infarction in the diabetic patient: Pathophysiology, clinical course and prognosis (1992) J Am Coll Cardiol, 20, pp. 736-744
Hammoud, T., Tanguay, J.-F., Bourassa, M.G., Management of coronary artery disease: Therapeutic options in patients with diabetes (2000) Journal of the American College of Cardiology, 36 (2), pp. 355-365. , DOI 10.1016/S0735-1097(00)00732-4, PII S0735109700007324
Braunwald, E., Antman, E.M., Beasley, J.W., Califf, R.M., Cheitlin, M.D., Hochman, J.S., ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina) (2000) J Am Coll Cardiol, 36, pp. 970-1062
Haffner, S.M., Lehto, S., Ronnemaa, T., Pyorala, K., Laakso, M., Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction (1998) New England Journal of Medicine, 339 (4), pp. 229-234. , DOI 10.1056/NEJM199807233390404
Consensus development conference on the diagnosis of coronary heart disease in people with diabetes: 10-11 February 1998, Miami, Florida (1998) Diabetes Care, 21, pp. 1551-1559. , American Diabetes Association
Miettinen, H., Lehto, S., Salomaa, V., Mähönen, M., Niemelä, M., Haffner, S.M., Impact of diabetes on mortality after the first myocardial infarction (1998) Diabetes Care, 21, pp. 69-75. , The FINMONICA Myocardial Infarction Register Study Group
Haffner, S.M., Coronary heart disease in patients with diabetes (2000) New Engl J Med, 342, pp. 1040-1042
Giri, S., Shaw, L.J., Murthy, D.R., Travin, M.I., Miller, D.D., Hachamovitch, R., Impact of diabetes on the risk stratification using stress single-photon emission computed tomography myocardial perfusion imaging in patients with symptoms suggestive of coronary artery disease (2002) Circulation, 105, pp. 32-40
Saito, I., Folsom, A.R., Brancati, F.L., Duncan, B.B., Chambless, L.E., McGovern, P.G., Nontraditional risk factors for coronary heart disease incidence among persons with diabetes: The Atherosclerosis Risk in Communities (ARIC) Study (2000) Ann Intern Med, 133, pp. 81-91
Clarkson, P., Celermajer, D.S., Donald, A.E., Sampson, M., Sorensen, K.E., Adams, M., Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low-density lipoprotein cholesterol levels (1996) J Am Coll Cardiol, 28, pp. 573-579
Storto, G., Pellegrino, T., Sorrentino, A.R., Luongo, L., Petretta, M., Cuocolo, A., Estimation of coronary flow reserve by sestamibi imaging in type 2 diabetic patients with normal coronary arteries (2007) Journal of Nuclear Cardiology, 14 (2), pp. 194-199. , DOI 10.1016/j.nuclcard.2006.12.327, PII S107135810700030X
Janand-Delenne, B., Savin, B., Habib, G., Bory, M., Vague, P., Lassmann-Vague, V., Silent myocardial ischemia in patients with diabetes (1999) Diabetes Care, 22, pp. 1396-1400
Koistinen, M.J., Prevalence of asymptomatic myocardial ischaemia in diabetic subjects (1990) BMJ, 301, pp. 92-95
Naka, M., Hiramatsu, K., Aizawa, T., Momose, A., Yoshizawa, K., Shigematsu, S., Silent myocardial ischemia in patients with noninsulin-dependent diabetes mellitus as judged by treadmill exercise testing and coronary angiography (1992) Am Heart J, 123, pp. 46-53
Nesto, R.W., Screening for asymptomatic coronary artery disease in diabetes (1999) Diabetes Care, 22, pp. 1393-1395
Cooper, S., Caldwell, J.H., Coronary artery disease in people with diabetes: Diagnostic and risk factor evaluation (1999) Clin Diabetes, 17, pp. 58-82
Wackers, F.J., Young, L.H., Inzucchi, S.E., Chyun, D.A., Davey, J.A., Barrett, E.J., Detection of ischemia in asymptomatic diabetics investigators. Detection of silent myocardial ischemia in asymptomatic diabetic subjects: The DIAD study (2004) Diabetes Care, 27, pp. 1954-1961
Hachamovitch, R., Berman, D.S., Kiat, H., Cohen, I., Cabico, J.A., Friedman, J., Exercise myocardial perfusion SPECT in patients without known coronary artery disease: Incremental prognostic value and use in risk stratification (1996) Circulation, 93, pp. 905-914
Iskandrian, A.S., Chae, S.C., Heo, J., Stanberry, C.D., Wasserleben, V., Cave, V., Independent and incremental prognostic value of exercise single-photon emission computed tomographic (SPECT) thallium imaging in coronary artery disease (1993) Journal of the American College of Cardiology, 22 (3), pp. 665-670
Shaw, L.J., Hachamovitch, R., Heller, G.V., Marwick, T.H., Travin, M.I., Iskandrian, A.E., Noninvasive strategies for the estimation of cardiac risk in stable chest pain patients (2000) Am J Cardiol, 86, pp. 1-7. , The Economics of Noninvasive Diagnosis (END) Study Group
Berman, D.S., Hachamovitch, R., Kiat, H., Cohen, I., Cabico, J.A., Wang, F.P., Incremental value of prognostic testing in patients with known or suspected ischemic heart disease: A basis for optimal utilization of exercise technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography (1995) J Am Coll Cardiol, 26, pp. 639-647
Di Carli, M.F., Hachamovitch, R., Should we screen for occult coronary artery disease among asymptomatic patients with diabetes? (2005) J Am Coll Cardiol, 45, pp. 50-53
Diamond, G.A., Staniloff, H.M., Forrester, J.S., Pollok, B.H., Swan, H.J.C., Computer assisted diagnosis in the noninvasive evaluation of patients with suspected coronary artery disease (1983) J Am Coll Cardiol, 1, pp. 444-455
Acampa, W., Evangelista, L., Petretta, M., Liuzzi, R., Cuocolo, A., Usefulness of stress cardiac single-photon emission computed tomographic imaging late after percutaneous coronary intervention for assessing cardiac events and time to such events (2007) Am J Cardiol, 100, pp. 436-441
Acampa, W., Petretta, M., Evangelista, L., Nappi, G., Luongo, L., Petretta, M.P., Stress cardiac single-photon emission computed tomographic imaging late after coronary artery bypass surgery for risk stratification and estimation of time to cardiac events (2008) J Thorac Cardiovasc Surg, 136, pp. 46-51
Petretta, M., Acampa, W., Evangelista, L., Daniele, S., Ferro, A., Cuocolo, A., Impact of Inducible Ischemia by Stress SPECT (IDIS) Investigators. Impact of inducible ischemia by stress SPECT in cardiac risk assessment in diabetic patients: Rationale and design of a prospective, multicenter trial (2008) J Nucl Cardiol, 15, pp. 100-104
Gibbons, R.J., Chatterjee, K., Daley, J., Douglas, J.S., Finn, S.D., Gardin, J.M., ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: Executive summary and recommendations. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients with Chronic Stable Angina) (1999) Circulation, 99, pp. 2829-2848
Raggi, P., Bellasi, A., Ratti, C., Ischemia imaging and plaque imaging in diabetes: Complementary tools to improve cardiovascular risk management (2005) Diabetes Care, 28 (11), pp. 2787-2794. , http://care.diabetesjournals.org/cgi/reprint/28/11/2787, DOI 10.2337/diacare.28.11.2787
Anand, D.V., Lim, E., Hopkins, D., Corder, R., Shaw, L.J., Sharp, P., Risk stratification in uncomplicated type 2 diabetes: Prospective evaluation of the combined use of coronary artery calcium imaging and selective myocardial perfusion scintigraphy (2006) Eur Heart J, 27, pp. 713-721
Vanzetto, G., Ormezzano, O., Fagret, D., Comet, M., Denis, B., Machecourt, J., Long-term additive prognostic value of thallium-201 myocardial perfusion imaging over clinical and exercise stress test in low to intermediate risk patients: Study in 1137 patients with 6-year follow-up (1999) Circulation, 100, pp. 1521-1527
Wackers, F.J., Diabetes and coronary artery disease: The role of stress myocardial perfusion imaging (2005) Cleve Clin J Med, 72, pp. 21-33
Bax, J.J., Van Der Wall, E.E., De Roos, A., Poldermans, D., State of the art and future directions (2005) Clinical Nuclear Cardiology, pp. 535-555. , 3rd ed. Zaret Bl, Beller GA, Eds. Philadelphia, Mosby
Picano, E., Bedetti, G., Varga, A., Cseh, E., The comparable diagnostic accuracies of dobutamine-stress and dipyridamole-stress echocardiographies: A meta-analysis (2000) Coronary Artery Disease, 11 (2), pp. 151-159. , DOI 10.1097/00019501-200003000-00010
Ferro, A., Pellegrino, T., Spinelli, L., Acampa, W., Petretta, M., Cuocolo, A., Comparison between Dobutamine Echocardiography and Single-Photon Emission Computed Tomography for Interpretive Reproducibility (2007) American Journal of Cardiology, 100 (8), pp. 1239-1244. , DOI 10.1016/j.amjcard.2007.05.041, PII S0002914907013288
Hennessy, T.G., Codd, M.B., Kane, G., McCarthy, C., McCann, H.A., Sugrue, D.D., Evaluation of patients with diabetes mellitus for coronary artery disease using dobutamine stress echocardiography (1997) Coronary Artery Disease, 8 (3-4), pp. 171-174
Dakik, H.A., Mahmarian, J.J., Kimball, K.T., Koutelou, M.G., Medrano, R., Verani, M.S., Prognostic value of exercise201Tl tomography in patients treated with thrombolytic therapy during acute myocardial infarction (1996) Circulation, 94 (11), pp. 2735-2742
Chiamvimonvat, V., Goodman, S.G., Langer, A., Barr, A., Freeman, M.R., Prognostic value of dipyridamole SPECT imaging in low-risk patients after myocardial infarction (2001) Journal of Nuclear Cardiology, 8 (2), pp. 136-143. , DOI 10.1067/mnc.2001.112099
Spinelli, L., Petretta, M., Acampa, W., He, W., Petretta, A., Bonaduce, D., Prognostic value of combined assessment of regional left ventricular function and myocardial perfusion by dobutamine and rest gated SPECT in patients with uncomplicated acute myocardial infarction (2003) J Nucl Med, 44, pp. 1023-1029
Elhendy, A., Schinkel, A.F.L., Van Domburg, R.T., Bax, J.J., Poldermans, D., Comparison of late outcome in patients with versus without angina pectoris having reversible perfusion abnormalities during dobutamine stress technetium-99m sestamibi single-photon emission computed tomography (2003) American Journal of Cardiology, 91 (3), pp. 264-268. , DOI 10.1016/S0002-9149(02)03152-1, PII S0002914902031521
Marwick, T.H., Mehta, R., Arheart, K., Lauer, M.S., Use of exercise echocardiography for prognostic evaluation of patients with known or suspected coronary artery disease (1997) Journal of the American College of Cardiology, 30 (1), pp. 83-90. , DOI 10.1016/S0735-1097(97)00148-4, PII S0735109797001484
Olmos, L.I., Dakik, H., Gordon, R., Dunn, J.K., Verani, M.S., Quiñones, M.A., Long-term prognostic value of exercise echocardiography compared with exercise Tl-201, ECG, and clinical variables in patients evaluated for coronary artery disease (1998) Circulation, 98, pp. 2679-2686
Hoque, A., Maaieh, M., Longaker, R.A., Stoddard, M.F., Exercise echocardiography and thallium-201 single-photon emission computed tomography stress test for 5- And 10-year prognosis of mortality and specific cardiac events (2002) J Am Soc Echocardiogr, 15, pp. 1326-1334
Acampa, W., Spinelli, L., Petretta, M., De Lauro, F., Ibello, F., Cuocolo, A., Prognostic value of myocardial ischemia in patients with uncomplicated acute myocardial infarction: Direct comparison of stress echocardiography and myocardial perfusion imaging (2005) Journal of Nuclear Medicine, 46 (3), pp. 417-423
Hung, M.-J., Wang, C.-H., Cherng, W.-J., Can dobutamine stress echocardiography predict cardiac events in non-revascularized diabetic patients following acute myocardial infarction? (1999) Chest, 116, pp. 1224-1232
Marwick, T.H., Case, C., Sawada, S., Vasey, C., Short, L., Lauer, M., Use of stress echocardiography to predict mortality in patients with diabetes and known or suspected coronary artery disease (2002) Diabetes Care, 25 (6), pp. 1042-1048. , DOI 10.2337/diacare.25.6.1042
Elhendy, A., Arruda, A.M., Mahoney, D.W., Pellikka, P.A., Prognostic stratification of diabetic patients by exercise echocardiography (2001) J Am Coll Cardiol, 37, pp. 1551-1557
Bigi, R., Desideri, A., Cortigiani, L., Bax, J.J., Celegon, L., Fiorentini, C., Stress echocardiography for risk stratification of diabetic patients with known or suspected coronary artery disease (2001) Diabetes Care, 24 (9), pp. 1596-1601
Sozzi, F.B., Elhendy, A., Roelandt, J.R., Van Domburg, R.T., Schinkel, A.F., Vourvouri, E.C., Prognostic value of dobutamine stress echocardiography in patients with diabetes (2003) Diabetes Care, 26, pp. 1074-1078
D'Andrea, A., Severino, S., Caso, P., De Simone, L., Liccardo, B., Forni, A., Prognostic value of pharmacological stress echocardiography in diabetic patients (2003) Eur J Echocardiogr, 4, pp. 202-208
Kamalesh, M., Matorin, R., Sawada, S., Prognostic value of a negative stress echocardiographic study in diabetic patients (2002) Am Heart J, 143, pp. 163-168
Cuocolo, A., Acampa, W., Imbriaco, M., De Luca, Iovino, G.L., Salvatore, M., The many ways to myocardial perfusion imaging (2005) Q J Nucl Med Mol Imaging, 49, pp. 4-18
Cuocolo, A., Nicolai, E., Soricelli, A., Pace, L., Nappi, A., Sullo, P., Technetium 99m-labeled tetrofosmin myocardial tomography in patients with coronary artery disease: Comparison between adenosine and dynamic exercise stress testing (1996) J Nucl Cardiol, 3, pp. 194-203
Leppo, J., Meerdink, D., Comparison of the myocardial uptake of a technetium-labeled isonitrile analog and thallium (1989) Circ Res, 65, pp. 632-639
Sinusas, A.J., Shi, Q.-X., Saltzberg, M.T., Vitols, P., Jain, D., Wackers, F.J.T., Zaret, B.L., Technetium-99m-tetrofosmin to assess myocardial blood flow: Experimental validation in an intact canine model of ischemia (1994) Journal of Nuclear Medicine, 35 (4), pp. 664-671
Higley, B., Smith, F.W., Smith, T., Gemmell, H.G., Das Gupta, P., Gvozdanovic, D.V., Technetium-99m-1,2 bis (bis(2-ethoxyethyl)phosphino) ethane: Human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent (1993) J Nucl Med, 34, pp. 30-38
Acampa, W., Cuocolo, A., Sullo, P., Varrone, A., Nicolai, E., Pace, L., Petretta, M., Salvatore, M., Direct comparison of technetium 99m-sestamibi and technetium 99m-tetrofosmin cardiac single photon emission computed tomography in patients with coronary artery disease (1998) Journal of Nuclear Cardiology, 5 (3), pp. 265-274. , DOI 10.1016/S1071-3581(98)90128-3
Leppo, J.A., Comparison of pharmacologic stress agents (1996) J Nucl Cardiol, 3 (PART 2), pp. S22-S26
Petretta, M., Costanzo, P., Acampa, W., Imbriaco, M., Ferro, A., Filardi, P.P., Noninvasive assessment of coronary anatomy and myocardial perfusion: Going toward an integrated imaging approach (2008) J Cardiovasc Med, 9, pp. 977-986
Underwood, S.R., Anagnostopoulos, C., Cerqueira, M., Ell, P.J., Flint, E.J., Harbinson, M., Myocardial perfusion scintigraphy: The evidence (2004) Eur J Nucl Med Mol Imaging, 2, pp. 261-291
Bateman, T.M., Cullom, S.J., Attenuation correction single-photon emission computed tomography myocardial perfusion imaging (2005) Seminars in Nuclear Medicine, 35 (1), pp. 37-51. , DOI 10.1053/j.semnuclmed.2004.09.003, PII S0001299804000625, Cardiovascular Nuclear Medicine
Danias, P.G., Ahlberg, A.W., Clark III, B.A., Messineo, F., Levine, M.G., McGill, C.C., Combined assessment of myocardial perfusion and left ventricular function with exercise technetium-99m sestamibi gated single-photon emission computed tomography can differentiate between ischemic and nonischemic dilated cardiomyopathy (1998) Am J Cardiol, 82, pp. 1253-1258
Kang, X., Berman, D.S., Lewin, H., Miranda, R., Erel, J., Friedman, J.D., Amanullah, A.M., Comparative ability of myocardial perfusion single-photon emission computed tomography to detect coronary artery disease in patients with and without diabetes mellitus (1999) American Heart Journal, 137 (5), pp. 949-957. , DOI 10.1016/S0002-8703(99)70421-7
Iskander, S., Iskandrian, A.E., Risk assessment using single-photon emission computed tomographic technetium-99m sestamibi imaging (1998) Journal of the American College of Cardiology, 32 (1), pp. 57-62. , DOI 10.1016/S0735-1097(98)00177-6, PII S0735109798001776
Ladenheim, M.L., Pollock, B.H., Rozanski, A., Extent and severity of myocardial hypoperfusion as predictors of prognosis in patients with suspected coronary artery disease (1986) Journal of the American College of Cardiology, 7 (3), pp. 464-471
Sharir, T., Germano, G., Kavanagh, P.B., Lai, S., Cohen, I., Lewin, H.C., Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography (1999) Circulation, 100, pp. 1035-1042
Kang, X., Barman, D.S., Lewin, H.C., Cohen, I., Friedman, J.D., Germano, G., Incremental prognostic value of myocardial perfusion single photon emission computer tomography in patients with diabetes mellitus (1999) Am Heart J, 138, pp. 1025-1032
Rumberger, J.A., Simons, D.B., Fitzpatrick, L.A., Sheedy, P.F., Schwartz, R.S., Coronary artery calcium area by electron beam computed tomography and coronary atherosclerotic plaque area: A histopathologic correlative study (1995) Circulation, 92, pp. 2157-2162
Pletcher, M.J., Tice, J.A., Pignone, M., Browner, W.S., Using the coronary artery calcium score to predict coronary heart disease events: A systematic review and meta-analysis (2004) Arch Intern Med, 164, pp. 126-128
Raggi, P., Shaw, L.J., Berman, D.S., Callister, T.Q., Prognostic value of coronary artery calcium screening in subjects with and without diabetes (2004) J Am Coll Cardiol, 43, pp. 1663-1669
Bax, J.J., Beanlands, R.S., Klocke, F.J., Knuuti, J., Lammertsma, A.A., Schaefers, M.A., Diagnostic and clinical perspectives of fusion imaging in cardiology: Is the total greater than the sum of its parts? (2007) Heart, 93, pp. 16-22
Bischof Delaloye, A., Carrio, I., Cuocolo, A., Gourtsoyiannis, N., Knapp, W., McCall, I., White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (2007) Eur J Nucl Med Mol Imaging, 34, pp. 1147-1151
Kalki, K., Blankespoor, S.C., Brown, J.K., Hasegawa, B.H., Dae, M.W., Chin, M., Myocardial perfusion imaging with a combined x-ray CT and SPECT system (1997) J Nucl Med, 10, pp. 1535-1540
Wallis, J.W., Miller, T.R., Koppel, P., Attenuation correction in cardiac SPECT without a transmission measurement (1995) J Nucl Med, 3, pp. 506-512
Schindler, T.H., Magosaki, N., Oser, U., Solzbach, U., Just, H., New image processing technique for a combined three dimensional display of myocardial perfusion parameter and reconstructed coronary artery tree from digital data of coronary angiograms (1999) Computers in Cardiology, pp. 655-658
Faber, T.L., Santana, C.A., Garcia, E.V., Candell-Riera, J., Folks, R.D., Peifer, J.W., Hopper, A., Klein, J.L., Three-dimensional fusion of coronary arteries with myocardial perfusion distributions: Clinical validation (2004) Journal of Nuclear Medicine, 45 (5), pp. 745-753. , http://jnm.snmjournals.org/cgi/reprint/45/5/745
Nakaura, T., Utsunomiya, D., Shiraishi, S., Tomiguchi, S., Honda, T., Ogawa, H., Three-dimensional cardiac image fusion using new CT angiography and SPECT methods (2005) AJR Am J Roentgenol, 185, pp. 1554-1557
Di Carli, M.F., Dorbala, S., Curillova, Z., Kwong, R.J., Goldhaber, S.Z., Rybicki, F.J., Hachamovitch, R., Relationship between CT coronary angiography and stress perfusion imaging in patients with suspected ischemic heart disease assessed by integrated PET-CT imaging (2007) Journal of Nuclear Cardiology, 14 (6), pp. 799-809. , DOI 10.1016/j.nuclcard.2007.07.012, PII S1071358107005454
Mokdad, A. H., Ford, E. S., Bowman, B. A., Nelson, D. E., Engelgau, M. M., Vinicor, F., Diabetes trends in the US: 1990-1998 (2000) Diabetes Care, 23, pp. 1278-128
Morrish, N. J., Wang, S. -L., Stevens, L. K., Fuller, J. H., Keen, H., Lee, E. T., Lu, M., Bennett, P. H., Mortality and causes of death in the WHO multinational study of vascular disease in diabetes (2001) Diabetologia, 44 (SUPPL. 2), pp. S14-S21
Jacoby, R. M., Nesto, R. W., Acute myocardial infarction in the diabetic patient: Pathophysiology, clinical course and prognosis (1992) J Am Coll Cardiol, 20, pp. 736-744
Haffner, S. M., Lehto, S., Ronnemaa, T., Pyorala, K., Laakso, M., Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction (1998) New England Journal of Medicine, 339 (4), pp. 229-234. , DOI 10. 1056/NEJM199807233390404
Haffner, S. M., Coronary heart disease in patients with diabetes (2000) New Engl J Med, 342, pp. 1040-1042
Giri, S., Shaw, L. J., Murthy, D. R., Travin, M. I., Miller, D. D., Hachamovitch, R., Impact of diabetes on the risk stratification using stress single-photon emission computed tomography myocardial perfusion imaging in patients with symptoms suggestive of coronary artery disease (2002) Circulation, 105, pp. 32-40
Koistinen, M. J., Prevalence of asymptomatic myocardial ischaemia in diabetic subjects (1990) BMJ, 301, pp. 92-95
Nesto, R. W., Screening for asymptomatic coronary artery disease in diabetes (1999) Diabetes Care, 22, pp. 1393-1395
Wackers, F. J., Young, L. H., Inzucchi, S. E., Chyun, D. A., Davey, J. A., Barrett, E. J., Detection of ischemia in asymptomatic diabetics investigators. Detection of silent myocardial ischemia in asymptomatic diabetic subjects: The DIAD study (2004) Diabetes Care, 27, pp. 1954-1961
Iskandrian, A. S., Chae, S. C., Heo, J., Stanberry, C. D., Wasserleben, V., Cave, V., Independent and incremental prognostic value of exercise single-photon emission computed tomographic (SPECT) thallium imaging in coronary artery disease (1993) Journal of the American College of Cardiology, 22 (3), pp. 665-670
Shaw, L. J., Hachamovitch, R., Heller, G. V., Marwick, T. H., Travin, M. I., Iskandrian, A. E., Noninvasive strategies for the estimation of cardiac risk in stable chest pain patients (2000) Am J Cardiol, 86, pp. 1-7. , The Economics of Noninvasive Diagnosis (END) Study Group
Berman, D. S., Hachamovitch, R., Kiat, H., Cohen, I., Cabico, J. A., Wang, F. P., Incremental value of prognostic testing in patients with known or suspected ischemic heart disease: A basis for optimal utilization of exercise technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography (1995) J Am Coll Cardiol, 26, pp. 639-647
Di Carli, M. F., Hachamovitch, R., Should we screen for occult coronary artery disease among asymptomatic patients with diabetes? (2005) J Am Coll Cardiol, 45, pp. 50-53
Diamond, G. A., Staniloff, H. M., Forrester, J. S., Pollok, B. H., Swan, H. J. C., Computer assisted diagnosis in the noninvasive evaluation of patients with suspected coronary artery disease (1983) J Am Coll Cardiol, 1, pp. 444-455
Gibbons, R. J., Chatterjee, K., Daley, J., Douglas, J. S., Finn, S. D., Gardin, J. M., ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: Executive summary and recommendations. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients with Chronic Stable Angina) (1999) Circulation, 99, pp. 2829-2848
Anand, D. V., Lim, E., Hopkins, D., Corder, R., Shaw, L. J., Sharp, P., Risk stratification in uncomplicated type 2 diabetes: Prospective evaluation of the combined use of coronary artery calcium imaging and selective myocardial perfusion scintigraphy (2006) Eur Heart J, 27, pp. 713-721
Wackers, F. J., Diabetes and coronary artery disease: The role of stress myocardial perfusion imaging (2005) Cleve Clin J Med, 72, pp. 21-33
Bax, J. J., Van Der Wall, E. E., De Roos, A., Poldermans, D., State of the art and future directions (2005) Clinical Nuclear Cardiology, pp. 535-555. , 3rd ed. Zaret Bl, Beller GA, Eds. Philadelphia, Mosby
Hennessy, T. G., Codd, M. B., Kane, G., McCarthy, C., McCann, H. A., Sugrue, D. D., Evaluation of patients with diabetes mellitus for coronary artery disease using dobutamine stress echocardiography (1997) Coronary Artery Disease, 8 (3-4), pp. 171-174
Dakik, H. A., Mahmarian, J. J., Kimball, K. T., Koutelou, M. G., Medrano, R., Verani, M. S., Prognostic value of exercise201Tl tomography in patients treated with thrombolytic therapy during acute myocardial infarction (1996) Circulation, 94 (11), pp. 2735-2742
Marwick, T. H., Mehta, R., Arheart, K., Lauer, M. S., Use of exercise echocardiography for prognostic evaluation of patients with known or suspected coronary artery disease (1997) Journal of the American College of Cardiology, 30 (1), pp. 83-90. , DOI 10. 1016/S0735-1097 (97) 00148-4, PII S0735109797001484
Olmos, L. I., Dakik, H., Gordon, R., Dunn, J. K., Verani, M. S., Qui ones, M. A., Long-term prognostic value of exercise echocardiography compared with exercise Tl-201, ECG, and clinical variables in patients evaluated for coronary artery disease (1998) Circulation, 98, pp. 2679-2686
Hung, M. -J., Wang, C. -H., Cherng, W. -J., Can dobutamine stress echocardiography predict cardiac events in non-revascularized diabetic patients following acute myocardial infarction? (1999) Chest, 116, pp. 1224-1232
Marwick, T. H., Case, C., Sawada, S., Vasey, C., Short, L., Lauer, M., Use of stress echocardiography to predict mortality in patients with diabetes and known or suspected coronary artery disease (2002) Diabetes Care, 25 (6), pp. 1042-1048. , DOI 10. 2337/diacare. 25. 6. 1042
Sozzi, F. B., Elhendy, A., Roelandt, J. R., Van Domburg, R. T., Schinkel, A. F., Vourvouri, E. C., Prognostic value of dobutamine stress echocardiography in patients with diabetes (2003) Diabetes Care, 26, pp. 1074-1078
DePuey, E. G., Berman, D. S., Garcia, E. V., (1996) Cardiac SPECT Imaging, , Philadelphia: Lippincott-Raven
Sinusas, A. J., Shi, Q. -X., Saltzberg, M. T., Vitols, P., Jain, D., Wackers, F. J. T., Zaret, B. L., Technetium-99m-tetrofosmin to assess myocardial blood flow: Experimental validation in an intact canine model of ischemia (1994) Journal of Nuclear Medicine, 35 (4), pp. 664-671
Leppo, J. A., Comparison of pharmacologic stress agents (1996) J Nucl Cardiol, 3 (PART 2), pp. S22-S26
Underwood, S. R., Anagnostopoulos, C., Cerqueira, M., Ell, P. J., Flint, E. J., Harbinson, M., Myocardial perfusion scintigraphy: The evidence (2004) Eur J Nucl Med Mol Imaging, 2, pp. 261-291
Bateman, T. M., Cullom, S. J., Attenuation correction single-photon emission computed tomography myocardial perfusion imaging (2005) Seminars in Nuclear Medicine, 35 (1), pp. 37-51. , DOI 10. 1053/j. semnuclmed. 2004. 09. 003, PII S0001299804000625, Cardiovascular Nuclear Medicine
Danias, P. G., Ahlberg, A. W., Clark III, B. A., Messineo, F., Levine, M. G., McGill, C. C., Combined assessment of myocardial perfusion and left ventricular function with exercise technetium-99m sestamibi gated single-photon emission computed tomography can differentiate between ischemic and nonischemic dilated cardiomyopathy (1998) Am J Cardiol, 82, pp. 1253-1258
Ladenheim, M. L., Pollock, B. H., Rozanski, A., Extent and severity of myocardial hypoperfusion as predictors of prognosis in patients with suspected coronary artery disease (1986) Journal of the American College of Cardiology, 7 (3), pp. 464-471
Rumberger, J. A., Simons, D. B., Fitzpatrick, L. A., Sheedy, P. F., Schwartz, R. S., Coronary artery calcium area by electron beam computed tomography and coronary atherosclerotic plaque area: A histopathologic correlative study (1995) Circulation, 92, pp. 2157-2162
Pletcher, M. J., Tice, J. A., Pignone, M., Browner, W. S., Using the coronary artery calcium score to predict coronary heart disease events: A systematic review and meta-analysis (2004) Arch Intern Med, 164, pp. 126-128
Bax, J. J., Beanlands, R. S., Klocke, F. J., Knuuti, J., Lammertsma, A. A., Schaefers, M. A., Diagnostic and clinical perspectives of fusion imaging in cardiology: Is the total greater than the sum of its parts? (2007) Heart, 93, pp. 16-22
Wallis, J. W., Miller, T. R., Koppel, P., Attenuation correction in cardiac SPECT without a transmission measurement (1995) J Nucl Med, 3, pp. 506-512
Schindler, T. H., Magosaki, N., Oser, U., Solzbach, U., Just, H., New image processing technique for a combined three dimensional display of myocardial perfusion parameter and reconstructed coronary artery tree from digital data of coronary angiograms (1999) Computers in Cardiology, pp. 655-658
Faber, T. L., Santana, C. A., Garcia, E. V., Candell-Riera, J., Folks, R. D., Peifer, J. W., Hopper, A., Klein, J. L., Three-dimensional fusion of coronary arteries with myocardial perfusion distributions: Clinical validation (2004) Journal of Nuclear Medicine, 45 (5), pp. 745-753. , http: //jnm. snmjournals. org/cgi/reprint/45/5/745
Di Carli, M. F., Dorbala, S., Curillova, Z., Kwong, R. J., Goldhaber, S. Z., Rybicki, F. J., Hachamovitch, R., Relationship between CT coronary angiography and stress perfusion imaging in patients with suspected ischemic heart disease assessed by integrated PET-CT imaging (2007) Journal of Nuclear Cardiology, 14 (6), pp. 799-809. , DOI 10. 1016/j. nuclcard. 2007. 07. 012, PII S1071358107005454
Cardiovascular risk stratification of diabetic patients
Diabetes mellitus is a complex clinical entity that will grow in importance in the future. The complications of diabetes have a significant impact on patient survival and quality of life, particularly with respect to coronary artery disease (CAD). Appropriate screening and aggressive intervention can significantly benefit many patients with diabetes. In addition, it is important to consider strategies useful not only in the diagnosis of CAD but also in the prognostic evaluation of diabetic patients with coronary disease. Prognostic data are essential in defining risk categories and to apply appropriate treatment for the degree of risk. Therefore, accurate cardiovascular risk stratification of patients with type 2 diabetes is required. However, this can be a problematic issue because the clinical presentation and progression of CAD differs between diabetic and nondiabetic subjects. In addition to a higher prevalence of CAD, patients with diabetes experience more diffuse and extensive coronary artery involvement, more often have left ventricular dysfunction, a more advanced coronary disease at the time of diagnosis, and more often experience silent ischemia. Furthermore, diabetic patients have frequently a less favorable response to revascularization procedures and a poorer long-term outcome. The purpose of this review is to discuss the relative role of various procedures for diagnosis of CAD and for cardiac risk stratification in patients with diabetes.
Cardiovascular risk stratification of diabetic patients