Combined therapy of Sr-89 and zoledronic acid in patients with painful bone metastases (671 views)
Bone (ISSN: 8756-3282), 2006 Jul; 39(1): 35-41.
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Paper type: Journal Article,
Impact factor: 3.829, 5-year impact factor: 4.312
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33744945763&partnerID=40&md5=51dc9a8b5692da3293ca33a4a3ae0912
Keywords: Bone Pain, Combined Therapy, Sr-89, Zoledronic Acid, Bisphosphonic Acid Derivative, Strontium 89, Adult, Aged, Article, Bleeding, Blood Toxicity, Bone Marrow Suppression, Bone Metastasis, Clinical Article, Clinical Feature, Controlled Study, Female, Human, Infection, Nephrotoxicity, Pain Assessment, Patient Monitoring, Physician, Rating Scale, Statistical Significance, Visual Analog Scale, 80 And Over, Bone Neoplasms, Breast Neoplasms, Combined Modality Therapy, Diphosphonates, Follow-Up Studies, Imidazoles, Middle Aged, Neoplasm Metastasis, Palliative Care, Prostatic Neoplasms, Strontium Radioisotopes, Time Factors, Treatment Outcome,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimages, National Council of Research, Naples, Italy
Department of Biomorphological and Functional Sciences, University Federico II of Naples, Italy
Department of Oncology, University Federico II of Naples, Italy
IRCCS, Neuromed, Pozzilli, Italy
Diagnostic Imaging, University of Naples Parthenope, Italy
References:
Not available.
Bone (ISSN: 8756-3282), 2006 Jul; 39(1): 35-41.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.829, 5-year impact factor: 4.312
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33744945763&partnerID=40&md5=51dc9a8b5692da3293ca33a4a3ae0912
Keywords: Bone Pain, Combined Therapy, Sr-89, Zoledronic Acid, Bisphosphonic Acid Derivative, Strontium 89, Adult, Aged, Article, Bleeding, Blood Toxicity, Bone Marrow Suppression, Bone Metastasis, Clinical Article, Clinical Feature, Controlled Study, Female, Human, Infection, Nephrotoxicity, Pain Assessment, Patient Monitoring, Physician, Rating Scale, Statistical Significance, Visual Analog Scale, 80 And Over, Bone Neoplasms, Breast Neoplasms, Combined Modality Therapy, Diphosphonates, Follow-Up Studies, Imidazoles, Middle Aged, Neoplasm Metastasis, Palliative Care, Prostatic Neoplasms, Strontium Radioisotopes, Time Factors, Treatment Outcome,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimages, National Council of Research, Naples, Italy
Department of Biomorphological and Functional Sciences, University Federico II of Naples, Italy
Department of Oncology, University Federico II of Naples, Italy
IRCCS, Neuromed, Pozzilli, Italy
Diagnostic Imaging, University of Naples Parthenope, Italy
References:
Not available.
Combined therapy of Sr-89 and zoledronic acid in patients with painful bone metastases
Purpose: We evaluated the pain response and daily discomfort in patients with painful bone metastases treated by merging 89Sr-chloride and zoledronic acid. The results were compared with those of patients who received 89Sr-chloride or zoledronic acid separately. Methods: 25 patients (12 women; mean age 65 ± 13 years) chronically treated with zoledronic acid underwent bone pain palliation with 150 MBq of 89Sr-chloride at least 6 months later that bisphoshonate therapy started (group A). 13 patients (6 women; mean age 70 ± 12 years) received 89Sr-chloride alone (group B) and 11 patients (5 women; mean age 69 ± 12 years) were chronically treated and continued to receive only zoledronic acid therapy (group C), both constituted the control groups. Patients kept a daily pain diary assessing both their discomfort and the pain of specific sites by using a visual analog scale (VAS), rating from 0 (no discomfort-no pain) to 10 (worst discomfort-pain). These diaries were reviewed weekly for 2 months and three different physicians rated the pain response on a scale of -2 (considerable deterioration) to +2 (considerable improvement). Results: Baseline characteristics were similar in the three groups. The reduction of total discomfort and of bone pain in the group A was significantly greater as compared to group B (P < 0.01) and group C (P < 0.01). During the monitored period, a significant improvement of clinical conditions was observed in the group A, varying the rate from -1 to 1 as compared to both groups B and C in which the rate changed from -1 to 0. Conclusion: Our findings indicate that combined therapy of 89Sr-chloride and zoledronic acid in patients with painful bone metastases is more effective in treating pain and improving clinical conditions than 89Sr-chloride or zoledronic acid used separately. © 2005 Elsevier Inc. All rights reserved.
Purpose: We evaluated the pain response and daily discomfort in patients with painful bone metastases treated by merging 89Sr-chloride and zoledronic acid. The results were compared with those of patients who received 89Sr-chloride or zoledronic acid separately. Methods: 25 patients (12 women; mean age 65 ± 13 years) chronically treated with zoledronic acid underwent bone pain palliation with 150 MBq of 89Sr-chloride at least 6 months later that bisphoshonate therapy started (group A). 13 patients (6 women; mean age 70 ± 12 years) received 89Sr-chloride alone (group B) and 11 patients (5 women; mean age 69 ± 12 years) were chronically treated and continued to receive only zoledronic acid therapy (group C), both constituted the control groups. Patients kept a daily pain diary assessing both their discomfort and the pain of specific sites by using a visual analog scale (VAS), rating from 0 (no discomfort-no pain) to 10 (worst discomfort-pain). These diaries were reviewed weekly for 2 months and three different physicians rated the pain response on a scale of -2 (considerable deterioration) to +2 (considerable improvement). Results: Baseline characteristics were similar in the three groups. The reduction of total discomfort and of bone pain in the group A was significantly greater as compared to group B (P < 0.01) and group C (P < 0.01). During the monitored period, a significant improvement of clinical conditions was observed in the group A, varying the rate from -1 to 1 as compared to both groups B and C in which the rate changed from -1 to 0. Conclusion: Our findings indicate that combined therapy of 89Sr-chloride and zoledronic acid in patients with painful bone metastases is more effective in treating pain and improving clinical conditions than 89Sr-chloride or zoledronic acid used separately. © 2005 Elsevier Inc. All rights reserved.
Combined therapy of Sr-89 and zoledronic acid in patients with painful bone metastases
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Combined therapy of Sr-89 and zoledronic acid in patients with painful bone metastases
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 3.883
View Export to BibTeX Export to EndNote
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Impact Factor: 3.935
View Export to BibTeX Export to EndNote
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10 Records (7 excluding Abstracts).
Total impact factor: 29.434 (19.208 excluding Abstracts).
Total 5 year impact factor: 32.102 (20.188 excluding Abstracts).
Total impact factor: 29.434 (19.208 excluding Abstracts).
Total 5 year impact factor: 32.102 (20.188 excluding Abstracts).
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