Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institute of Health (NIH), Bethesda, MD, United States
Department of Biomorphological and Functional Sciences, University of Naples Federico II, Institute of Biostructures and Bioimages, Naples, Italy
References: Not available.
Molecular imaging of tumor microenvironment
Tumor microenvironment consists of a number of components including host resident stromal cells, infiltrating immune cells and extracellular matrix. The architecture surrounding tumor cells is not static but is subjected to a continuous remodeling in response to the dynamic interplay between tumor and stromal cells and to the production of extracellular proteases. In addition all these microenvironmental components along with cancer cells are exposed to abnormal physiologic conditions such as hypoxia and acidic extracellular pH that may induce both adaptive and constitutive changes in cancer and stromal cells. In this review, we will primarily focus on the possibility to visualize in vivo tumor microenvironment components and conditions as well as interactions with cancer cells. The major goal is to highlight the difficulties and the opportunities of this approach and how each imaging technology helps to overcome specific challenge.
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(410 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A * Tumor Imaging(459 views) Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309. Impact Factor:1.148 ViewExport to BibTeXExport to EndNote