Biostructure and Bioimaging Institute, National Research Council, Edificio 10, Via Pansini, 5, 80131 Naples, Italy
SDN Foundation, Naples, Italy
Department of Neurological Sciences, University 'Federico ', Naples, Italy
Neurology, Hermitage Hospital, Capodimonte, Naples, Italy
Department of Biomorphological and Functional Sciences, University 'Federico ', Naples, Italy
Neuroradiology, University 'Federico ', Naples, Italy
References: Prinster, A., Quarantelli, M., Orefice, G., Grey matter loss in relapsing-remitting multiple sclerosis: A voxel-based morphometry study (2006) Neuroimage, 29, pp. 859-86
Sailer, M., Fischl, B., Salat, D., Tempelmann, C., Schonfeld, M.A., Busa, E., Bodammer, N., Dale, A., Focal thinning of the cerebral cortex in multiple sclerosis (2003) Brain, 126 (8), pp. 1734-1744. , DOI 10.1093/brain/awg175
Audoin, B., Davies, G.R., Finisku, L., Chard, D.T., Thompson, A.J., Miller, D.H., Localization of grey matter atrophy in early RRMS: A longitudinal study (2006) J Neurol, 253, pp. 1495-1501
Charil, A., Dagher, A., Lerch, J.P., Zijdenbos, A.P., Worsley, K.J., Evans, A.C., Focal cortical atrophy in multiple sclerosis: Relation to lesion load and disability (2007) Neuroimage, 34, pp. 509-517
Chen, J.T., Narayanan, S., Collins, D.L., Smith, S.M., Matthews, P.M., Arnold, D.L., Relating neocortical pathology to disability progression in multiple sclerosis using MRI (2004) Neuroimage, 23, pp. 1168-1175
Ceccarelli, A., Rocca, M.A., Pagani, E., A voxel-based morphometry study of grey matter loss in MS patients with different clinical phenotypes (2008) Neuroimage, 42, pp. 315-322
Bendfeldt, K., Kuster, P., Traud, S., Association of regional gray matter volume loss and progression of white matter lesions in multiple sclerosis - A longitudinal voxel-based morphometry study (2009) Neuroimage, 45, pp. 60-67
Chard, D.T., Griffin, C.M., Parker, G.J., Kapoor, R., Thompson, A.J., Miller, D.H., Brain atrophy in clinically early relapsing- Remitting multiple sclerosis (2002) Brain, 125, pp. 327-337
Ge, Y., Grossman, R.I., Udupa, J.K., Babb, J.S., Nyul, L.G., Kolson, D.L., Brain atrophy in relapsing-remitting multiple sclerosis: Fractional volumetric analysis of gray matter and white matter (2001) Radiology, 220 (3), pp. 606-610
Ashburner, J., Friston, K.J., Voxel-based morphometry - The methods (2000) Neuroimage, 11, pp. 805-821
Poser, C.M., Paty, D.W., Scheinberg, L., New diagnostic criteria for multiple sclerosis: Guidelines for research protocols (1983) Ann Neurol, 13, pp. 227-231
Lublin, F.D., Reingold, S.C., Defining the clinical course of multiple sclerosis: Results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis (1996) Neurology, 46, pp. 907-911
Kurtzke, J.F., Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS) (1983) Neurology, 33, pp. 1444-1452
Alfano, B., Brunetti, A., Larobina, M., Automated segmentation and measurement of global white matter lesion volume in patients with multiple sclerosis (2000) J Magn Reson Imaging, 12, pp. 799-807
Good, C.D., Johnsrude, I.S., Ashburner, J., Henson, R.N., Friston, K.J., Frackowiak, R.S., A voxel-based morphometric study of ageing in 465 normal adult human brains (2001) Neuroimage, 14, pp. 21-36
Friston, K.J., Holmes, A.P., Poline, J.B., Analysis of fMRI time-series revisited (1995) Neuroimage, 2, pp. 45-53
Ashburner, J., Neelin, P., Collins, D.L., Evans, A., Friston, K., Incorporating prior knowledge into image registration (1997) Neuroimage, 6, pp. 344-352
Woods, R.P., Grafton, S.T., Watson, J.D., Sicotte, N.L., Mazziotta, J.C., Automated image registration: II. Intersubject validation of linear and nonlinear models (1998) J Comput Assist Tomogr, 22, pp. 153-165
Genovese, C.R., Lazar, N.A., Nichols, T., Thresholding of statistical maps in functional neuroimaging using the false discovery rate (2002) Neuroimage, 15, pp. 870-878
Talairach, J., Tournoux, P., (1988) Co-planar Stereotaxic Atlas of the Human Brain. 3-dimensional Proportional System: An Approach to Cerebral Imaging, , Thieme, New York
Bermel, R.A., Bakshi, R., The measurement and clinical relevance of brain atrophy in multiple sclerosis (2006) Lancet Neurology, 5 (2), pp. 158-170. , DOI 10.1016/S1474-4422(06)70349-0, PII S1474442206703490
Pagani, E., Rocca, M.A., Gallo, A., Regional brain atrophy evolves differently in patients with multiple sclerosis according to clinical phenotype (2005) Am J Neuroradiol, 26, pp. 341-346
Henry, R.G., Shieh, M., Okuda, D.T., Evangelista, A., Gorno-Tempini, M.L., Pelletier, D., Regional grey matter atrophy in clinically isolated syndromes at presentation (2008) J Neurol Neurosurg Psychiatry, 79, pp. 1236-1244
Wiegell, M.R., Tuch, D.S., Larsson, H.B., Wedeen, V.J., Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imaging (2003) Neuroimage, 19, pp. 391-401
De Stefano, N., Matthews, P.M., Filippi, M., Evidence of early cortical atrophy in MS: Relevance to white matter changes and disability (2003) Neurology, 60, pp. 1157-1162
Gasperini, C., Paolillo, A., Giugni, E., Galgani, S., Bagnato, F., Mainero, C., Onesti, E., Pozzilli, C., MRI brain volume changes in relapsing-remitting multiple sclerosis patients treated with interferon beta-1 a (2002) Multiple Sclerosis, 8 (2), pp. 119-123
Rudick, R.A., Fisher, E., Lee, J.C., Duda, J.T., Simon, J., Brain atrophy in relapsing multiple sclerosis: Relationship to relapses, EDSS, and treatment with interferon beta-1a (2000) Mult Scler, 6, pp. 365-372
Zivadinov, R., Sepcic, J., Nasuelli, D., De Masi, R., Monti Bragadin, L., Tommasi, M.A., Zambito-Marsala, S., Zorzon, M., A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis (2001) Journal of Neurology Neurosurgery and Psychiatry, 70 (6), pp. 773-780. , DOI 10.1136/jnnp.70.6.773
Tomaiuolo, F., MacDonald, J.D., Caramanos, Z., Morphology, morphometry and probability mapping of the pars opercularis of the inferior frontal gyrus: An in vivo MRI analysis (1999) Eur J Neurosci, 11, pp. 3033-3046
Chiavaras, M.M., Legoualher, G., Evans, A., Petrides, M., Three-dimensional probabilistic atlas of the human orbitofrontal sulci in standardized stereotaxic space (2001) Neuroimage, 13, pp. 479-496
Rashid, W., Davies, G.R., Chard, D.T., Griffin, C.M., Altmann, D.R., Gordon, R., Thompson, A.J., Miller, D.H., Increasing cord atrophy in early relapsing-remitting multiple sclerosis: A 3 year study (2006) Journal of Neurology, Neurosurgery and Psychiatry, 77 (1), pp. 51-55. , DOI 10.1136/jnnp.2005.068338
A voxel-based morphometry study of disease severity correlates in relapsing- remitting multiple sclerosis
Previous studies have shown a preferential loss of grey matter in fronto-temporal regions in patients with multiple sclerosis. Studies of correlates of disease severity are more controversial, because some studies have suggested an association between sensorimotor cortex atrophy and Expanded Disability Status Scale score, while others did not find such a correlation. The objective of this study was to assess the correlation of regional loss of grey matter and white matter with indexes of clinical and radiological severity in relapsing–remitting multiple sclerosis, including the Expanded Disability Status Scale and lesion load. Correlations between Expanded Disability Status Scale, lesion load and disease duration were assessed in 128 patients with relapsing–remitting multiple sclerosis (Expanded Disability Status Scale range 1.0–6.0) using optimized voxel-based morphometry. Bilateral loss of grey matter in sensorimotor cortices was correlated with Expanded Disability Status Scale, and tissue loss also involved adjacent white matter, extending along pyramidal tracts to the brainstem. Increasing lesion load was correlated with loss of deep grey matter and white matter. No specific region of grey matter or white matter showed a significant correlation with disease duration. These findings support the hypothesis that motor neuron involvement plays a major role in the progression of physical disability. Lesion load accrual affects mainly highly interconnected subcortical structures, while disease duration has a less significant impact on brain atrophy, probably owing to the inter-subject heterogeneity of the clinical course of the disease.
A voxel-based morphometry study of disease severity correlates in relapsing- remitting multiple sclerosis