Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide(508 views) De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
Keywords: Angiogenesis, Drug Design, Nmr Spectroscopy, Peptides, Vegf, Cyclopeptide, Placental Growth Factor, Vasculotropin Inhibitor, Amino Acid Sequence, Article, Biological Activity, Cell Assay, Dna Hairpin, Drug Structure, Endothelium Cell, Human, Human Cell, In Vitro Study, Nuclear Magnetic Resonance, Protein Conformation, Blotting, Western, Cell Proliferation, Cell Survival, Endothelial Cells, Human Umbilical Vein Endothelial Cells, Biomolecular, Pregnancy Proteins, Protein Engineering, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-1,
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, Napoli 80134, Italy
Dipartimento di Scienze Farmaceutiche e Biomediche, Università di Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, SA, Italy
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D'Andrea, L. D., Del Gatto, A., De Rosa, L., Romanelli, A., Pedone, C., Peptides targeting angiogenesis related growth factor receptors (2009) Curr. Pharm. Des., 15, pp. 2414-2429
Christinger, H. W., Fuh, G., De Vos, A. M., Wiesmann, C., The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1 (2004) Journal of Biological Chemistry, 279 (11), pp. 10382-10388. , DOI 10. 1074/jbc. M313237200
Syud, F. A., Espinosa, J. F., Gellman, S. H., NMR-based quanfification of -sheet populations in aqueous solution through use of reference peptides for the folded and unfolded states [6] (1999) Journal of the American Chemical Society, 121 (49), pp. 11577-11578. , DOI 10. 1021/ja992733t
Cochran, A. G., Skelton, N. J., Starovasnik, M. A., Tryptophan zippers: Stable, monomeric -hairpins (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (10), pp. 5578-5583. , DOI 10. 1073/pnas. 091100898
Cochran, A. G., Tong, R. T., Starovasnik, M. A., Park, E. J., McDowell, R. S., Theaker, J. E., Skelton, N. J., A minimal peptide scaffold for -turn display: Optimizing a strand position in disulfide-cyclized -hairpins (2001) Journal of the American Chemical Society, 123 (4), pp. 625-632. , DOI 10. 1021/ja003369x
Garcia-Aranda, M. I., Mirassou, Y., Gautier, B., Martin-Martinez, M., Inguimbert, N., Vidal, M., Garcia-Lopez, M. T., Perez De Vega, M. J., Disulfide and amide-bridged cyclic peptide analogues of the VEGF (8) (1) (-) (9) (1) fragment: Synthesis, conformational analysis and biological evaluation (2011) Bioorg. Med. Chem., 19, pp. 7526-7533
W thrich, K., (1986) NMR of Proteins and Nucleic Acids, , John Wiley & Sons New York
Wishart, D. S., Sykes, B. D., Richards, F. M., Relationship between nuclear magnetic resonance chemical shift and protein secondary structure (1991) Journal of Molecular Biology, 222 (2), pp. 311-333
Searle, M. S., Williams, D. H., Packman, L. C., A short linear peptide derived from the N-terminal sequence of ubiquitin folds into a water-stable non-native beta-hairpin (1995) Nat. Struct. Biol., 2, pp. 999-1006
Blanco, F. J., Jimenez, M. A., Pineda, A., Rico, M., Santoro, J., Nieto, J. L., NMR solution structure of the isolated N-terminal fragment of protein-G B1 domain. Evidence of trifluoroethanol induced native-like -hairpin formation (1994) Biochemistry, 33 (19), pp. 6004-6014. , DOI 10. 1021/bi00185a041
Sharman, G. J., Griffiths-Jones, S. R., Jourdan, M., Searle, M. S., Effects of amino acid, propensities and secondary structure interactions in modulating H chemical shifts in peptide and protein -sheet (2001) Journal of the American Chemical Society, 123 (49), pp. 12318-12324. , DOI 10. 1021/ja0116369
Goddard, T. D., Kneller, D. G., SPARKY, 3. , University of California, San Francisco
Masse, J. E., Keller, R., AutoLink: Automated sequential resonance assignment of biopolymers from NMR data by relative-hypothesis-prioritization-based simulated logic (2005) Journal of Magnetic Resonance, 174 (1), pp. 133-151. , DOI 10. 1016/j. jmr. 2005. 01. 017, PII S1090780705000108
Morris, K. F., Johnson, C. S., Mobility-ordered 2-Dimensional nuclear-magnetic-resonance spectroscopy (1992) J. Am. Chem. Soc., 114, pp. 776-777
Price, W. S., Pulsed-field gradient nuclear magnetic resonance as a tool for studying translational diffusion: Part I. Basic theory (1997) Concepts in Magnetic Resonance, 9 (5), pp. 299-336. , DOI 10. 1002/ (SICI) 1099-0534 (1997) 9: 5<299:: AID-CMR2>
3. 0. CO
Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide
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