Effects of enzyme-replacement therapy in patients with Anderson-Fabry disease: a prospective long-term cardiac magnetic resonance imaging study (567 views)
Heart (ISSN: 1355-6037, 1468-201x), 2009 Jul; 95(13): 1103-1107.
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Paper type: Letter, Journal Article,
Impact factor: 5.385, 5-year impact factor: 4.838
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-67649583702&partnerID=40&md5=a963c7aeaff474a0a34efb4bfa2c9cbd
Keywords: Acetylsalicylic Acid, Agalsidase Beta, Antilipemic Agent, Calcium Antagonist, Dipeptidyl Carboxypeptidase Inhibitor, Erythropoietin, Adult, Anderson Fabry Disease, Article, Clinical Article, Controlled Study, Disorders Of Lipid And Lipoprotein Metabolism, Drug Tolerability, Enzyme Replacement, Female, Heart Left Ventricle Function, Heart Left Ventricle Mass, Heart Left Ventricle Volume, Heart Ventricle Septum, Human, Long Term Care, Physical Examination, Priority Journal, Relaxation Time, Treatment Duration, X Chromosome Linked Disorder, Alpha-Galactosidase, Drug Administration Schedule, Hypertrophy, Left Ventricular, Isoenzymes, Magnetic Resonance Imaging, Middle Aged, Prospective Studies, Stroke Volume, Ventricular Function, Young Adult, Fluorodeoxyglucose F 18, Body Posture, Breast Cancer, Cancer Diagnosis, Computer Assisted Emission Tomography, Follow Up, Intermethod Comparison, Letter, Nuclear Magnetic Resonance Imaging,
Affiliations:
*** IBB - CNR ***
Department of Biomorphological and Functional Sciences, University Federico II, Naples, Italy
Department of Nephrology, University Federico II, Naples, Italy
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy
Department of National Research Council (IBB-CNR), University Federico II, Naples, Italy
Via Posillipo 196, 80123, Naples, Italy
References:
Not available.
Heart (ISSN: 1355-6037, 1468-201x), 2009 Jul; 95(13): 1103-1107.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 5.385, 5-year impact factor: 4.838
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-67649583702&partnerID=40&md5=a963c7aeaff474a0a34efb4bfa2c9cbd
Keywords: Acetylsalicylic Acid, Agalsidase Beta, Antilipemic Agent, Calcium Antagonist, Dipeptidyl Carboxypeptidase Inhibitor, Erythropoietin, Adult, Anderson Fabry Disease, Article, Clinical Article, Controlled Study, Disorders Of Lipid And Lipoprotein Metabolism, Drug Tolerability, Enzyme Replacement, Female, Heart Left Ventricle Function, Heart Left Ventricle Mass, Heart Left Ventricle Volume, Heart Ventricle Septum, Human, Long Term Care, Physical Examination, Priority Journal, Relaxation Time, Treatment Duration, X Chromosome Linked Disorder, Alpha-Galactosidase, Drug Administration Schedule, Hypertrophy, Left Ventricular, Isoenzymes, Magnetic Resonance Imaging, Middle Aged, Prospective Studies, Stroke Volume, Ventricular Function, Young Adult, Fluorodeoxyglucose F 18, Body Posture, Breast Cancer, Cancer Diagnosis, Computer Assisted Emission Tomography, Follow Up, Intermethod Comparison, Letter, Nuclear Magnetic Resonance Imaging,
Affiliations:
*** IBB - CNR ***
Department of Biomorphological and Functional Sciences, University Federico II, Naples, Italy
Department of Nephrology, University Federico II, Naples, Italy
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy
Department of National Research Council (IBB-CNR), University Federico II, Naples, Italy
Via Posillipo 196, 80123, Naples, Italy
References:
Not available.
Effects of enzyme-replacement therapy in patients with Anderson-Fabry disease: a prospective long-term cardiac magnetic resonance imaging study
Background: Anderson-Fabry disease is a multisystem X linked disorder of lipid metabolism frequently associated with cardiac symptoms, including left ventricular (LV) hypertrophy gradually impairing cardiac function. Evidence showing that enzyme-replacement therapy (ERT) can be effective in reducing LV hypertrophy and improving myocardial function in the long term is limited. Objective: This study aimed to assess the long-term effects of ERT with recombinant alpha-galactosidase A (agalsidase beta, Fabrazyme) on LV function and myocardial signal intensity in 11 patients with Anderson Fabry disease. Patients: Eleven patients (eight males, three females) with varying stages of genetically confirmed Anderson Fabry disease were examined by means of physical examination and magnetic resonance imaging before ERT with agalsidase beta at 1 mg/kg every other week (study 1) and after a mean treatment duration of 45 months (study 2). Results: At 45 months of treatment, LV mass and LV wall thickness had significantly reduced: 188 (SD 60) g versus 153 (47) g, and 16 (4) mm versus 14 (4) mm, respectively. Furthermore, a significant reduction in myocardial T2 relaxation times was noted in all myocardial regions, that is, interventricular septum 80 (5) ms versus 66 (8) ms, apex 79 (10) ms versus 64 (10) ms, and lateral wall 80 (8) ms versus 65 (16) ms. Changes in LV ejection fraction were not significant. Amelioration of clinical symptoms was observed in all patients. Conclusions: Long-term therapy with agalsidase beta at 1 mg/kg every 2 weeks was effective in significantly reducing LV hypertrophy, improving overall cardiac performance and ameliorating clinical symptoms in patients with Anderson-Fabry disease.
Background: Anderson-Fabry disease is a multisystem X linked disorder of lipid metabolism frequently associated with cardiac symptoms, including left ventricular (LV) hypertrophy gradually impairing cardiac function. Evidence showing that enzyme-replacement therapy (ERT) can be effective in reducing LV hypertrophy and improving myocardial function in the long term is limited. Objective: This study aimed to assess the long-term effects of ERT with recombinant alpha-galactosidase A (agalsidase beta, Fabrazyme) on LV function and myocardial signal intensity in 11 patients with Anderson Fabry disease. Patients: Eleven patients (eight males, three females) with varying stages of genetically confirmed Anderson Fabry disease were examined by means of physical examination and magnetic resonance imaging before ERT with agalsidase beta at 1 mg/kg every other week (study 1) and after a mean treatment duration of 45 months (study 2). Results: At 45 months of treatment, LV mass and LV wall thickness had significantly reduced: 188 (SD 60) g versus 153 (47) g, and 16 (4) mm versus 14 (4) mm, respectively. Furthermore, a significant reduction in myocardial T2 relaxation times was noted in all myocardial regions, that is, interventricular septum 80 (5) ms versus 66 (8) ms, apex 79 (10) ms versus 64 (10) ms, and lateral wall 80 (8) ms versus 65 (16) ms. Changes in LV ejection fraction were not significant. Amelioration of clinical symptoms was observed in all patients. Conclusions: Long-term therapy with agalsidase beta at 1 mg/kg every 2 weeks was effective in significantly reducing LV hypertrophy, improving overall cardiac performance and ameliorating clinical symptoms in patients with Anderson-Fabry disease.
Effects of enzyme-replacement therapy in patients with Anderson-Fabry disease: a prospective long-term cardiac magnetic resonance imaging study
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Effects of enzyme-replacement therapy in patients with Anderson-Fabry disease: a prospective long-term cardiac magnetic resonance imaging study
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Petretta M, Cuocolo A
Letter by Petretta and Cuocolo regarding article, "Four-variable risk model in men and women with heart failure" (335 views)
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Andreotti G, Citro V, Correra A, Cubellis MV
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Imbriaco M, Messalli G, Avitabile G, Cuocolo A, Maurea S, Soscia F, Pisani A
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Storto G, Pellegrino T, Sorrentino AR, Luongo L, Petretta M, Cuocolo A
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Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R
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Morisco C, Argenziano L, Sarno D, Cuocolo A, Romano M, Trimarco B
The practical aspects of treatment in heart failure (351 views)
Ann Ital Med Int (ISSN: 0393-9340), 1993 Oct; 8Suppl: 14S-19S.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Letter by Petretta and Cuocolo regarding article, "Four-variable risk model in men and women with heart failure" (335 views)
Circ-Heart Fail (ISSN: 1941-3289), 2014 Mar 1; 7(2): 380-380.
Impact Factor: 5.867
View Export to BibTeX Export to EndNote
Andreotti G, Citro V, Correra A, Cubellis MV
* A thermodynamic assay to test pharmacological chaperones for Fabry disease (403 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1840(3): 1214-1224.
Impact Factor: 4.882
View Export to BibTeX Export to EndNote
Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* Impact of diabetes on cardiac sympathetic innervation in patients with heart failure: a 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study (320 views)
Diabetes Care (ISSN: 1935-5548, 0149-5992), 2013 Sep; 36(8): 2395-2401.
Impact Factor: 8.57
View Export to BibTeX Export to EndNote
Berisio R
* Editorial: cell processes in bacterial diseases (414 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
Impact Factor: 1.994
View Export to BibTeX Export to EndNote
De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (457 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
View Export to BibTeX Export to EndNote
Messalli G, Imbriaco M, Avitabile G, Russo R, Iodice D, Spinelli L, Dellegrottaglie S, Cademartiri F, Salvatore M, Pisani A
* Role of cardiac MRI in evaluating patients with Anderson-Fabry disease: Assessing cardiac effects of long-term enzyme replacement therapy (335 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2012 Feb; 117(1): 19-28.
Impact Factor: 1.461
View Export to BibTeX Export to EndNote
Perrone-Filardi P, Paolillo S, Dellegrottaglie S, Gargiulo P, Savarese G, Marciano C, Casaretti L, Cecere M, Musella F, Pirozzi E, Parente A, Cuocolo A
* Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal (326 views)
Heart (ISSN: 1468-201x, 1355-6037), 2011 Nov; 97(22): 1828-1833.
Impact Factor: 4.223
View Export to BibTeX Export to EndNote
Manganelli F, Spadafora M, Varrella P, Peluso G, Sauro R, Di Lorenzo E, Rosato G, Daniele S, Cuocolo A
* Addition of atropine to submaximal exercise stress testing in patients evaluated for suspected ischaemia with SPECT imaging: a randomized, placebo-controlled trial (425 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 Feb; 38(2): 245-251.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Imbriaco M, Messalli G, Avitabile G, Cuocolo A, Maurea S, Soscia F, Pisani A
* Cardiac magnetic resonance imaging illustrating Anderson-Fabry disease progression (287 views)
Br J Radiol (ISSN: 0007-1285, 1748-880xelectronic, 0007-1285linking), 2010 Dec; 83(996): e249-e249.
Impact Factor: 2.062
View Export to BibTeX Export to EndNote
Pedone C, Di Pasquale G, Greco C, Gonzini L, Maggioni AP, Pavesi PC, Sabini A, Boccanelli A; In-Acs Outcome Investigators
* Prescription at discharge of recommended treatments for secondary prevention in patients with ST-segment elevation myocardial infarction according to reperfusion strategies. Results from the IN-ACS outcome study (457 views)
Acute Cardiac Care (ISSN: 1748-295x, 1748-2941), 2009; 11(4): 222-228.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Storto G, Pellegrino T, Sorrentino AR, Luongo L, Petretta M, Cuocolo A
* Estimation of coronary flow reserve by sestamibi imaging in type 2 diabetic patients with normal coronary arteries (507 views)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2007 Apr; 14(2): 194-199.
Impact Factor: 2.359
View Export to BibTeX Export to EndNote
Maestri R, Pinna G, Accardo A, Allegrini P, Balocchi R, D'ADDIO G, Ferrario M, Menicucci D, Porta A, Sassi R
* Nonlinear indices of heart rate variability in chronic heart failure patients: Redundancy and comparative clinical value (418 views)
J Cardiovasc Electrophysiol (ISSN: 1045-3873), 2007; 18(4): 425-433.
Impact Factor: 3.475
View Export to BibTeX Export to EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R
* 3. 0 T perfusion MR imaging (753 views)
Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812.
Impact Factor: 0.023
View Export to BibTeX Export to EndNote
Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (746 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
View Export to BibTeX Export to EndNote
Morisco C, Argenziano L, Sarno D, Cuocolo A, Romano M, Trimarco B
The practical aspects of treatment in heart failure (351 views)
Ann Ital Med Int (ISSN: 0393-9340), 1993 Oct; 8Suppl: 14S-19S.
Impact Factor: 0
View Export to BibTeX Export to EndNote
15 Records (14 excluding Abstracts).
Total impact factor: 45.99 (43.928 excluding Abstracts).
Total 5 year impact factor: 50.819 (48.464 excluding Abstracts).
Total impact factor: 45.99 (43.928 excluding Abstracts).
Total 5 year impact factor: 50.819 (48.464 excluding Abstracts).
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