Assessment of coronary flow reserve by sestamibi imaging in patients with typical chest pain and normal coronary arteries(355 views) Storto G, Sorrentino AR, Pellegrino T, Liuzzi R, Petretta M, Cuocolo A
Department of Biomorphological and Functional Sciences, Institute of Biostructures and Bioimages of the National Council of Research, University Federico II, Naples, Italy.
Department of Internal Medicine, Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy
SDN Foundation, Institute of Diagnostic and Nuclear Development, Naples, Italy
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Yang, E. H., Lerman, A., Angina pectoris with a normal coronary angiogram (2005) Herz, 30, pp. 17-25
Beltrame, J. F., Horowitz, J. D., ST elevation secondary to microvascular dysfunction (1999) J Am Coll Cardiol, 34, pp. 312-313
Lanza, G. A., Manzoli, A., Pasceri, V., Colonna, G., Cianflone, D., Crea, F., Ischemic-like ST-segment changes during Holter monitoring in patients with angina pectoris and normal coronary arteries but negative exercise testing (1997) Am J Cardiol, 79, pp. 1-6
Cannon, R. O., Epstein, S. E., "microvascular angina" as a cause of chest pain with angiographically normal coronary arteries (1988) Am J Cardiol, 61, pp. 1338-1343
Cannon, R. O., Camici, P. G., Epstein, S. E., Pathophysiological dilemma of syndrome X (1992) Circulation, 85, pp. 883-892
Galassi, A. R., Crea, F., Araujo, L. I., Lammertsma, A. A., Pupita, G., Yamamoto, Y., Comparison of regional myocardial blood flow in syndrome X and one-vessel coronary artery disease (1993) Am J Cardiol, 72, pp. 134-139
Reddy, K. G., Nair, R. N., Sheehan, H. M., Hodgson, J. M., Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis (1994) J Am Coll Cardiol, 23, pp. 833-843
Geltman, E. M., Henes, C. G., Senneff, M. J., Sobel, B. E., Bergmann, S. R., Increased myocardial perfusion at rest and diminished perfusion reserve in patients with angina and angiographically normal coronary arteries (1990) J Am Coll Cardiol, 16, pp. 586-595
Meeder, J. G., Blanksma, P. K., Van Der Wall, E. E., Willemsen, A. T., Pruim, J., Anthonio, R. L., Coronary vasomotion in patients with syndrome X: Evaluation with positron emission tomography and parametric myocardial perfusion imaging (1997) Eur J Nucl Med, 24, pp. 530-537
Quyyumi, A. A., Cannon, R. O., Panza, J. A., Diodati, J. G., Epstein, S. E., Endothelial dysfunction in patients with chest pain and normal coronary arteries (1992) Circulation, 86, pp. 1864-1871
Bortone, A. S., Hess, O. M., Eberli, F. R., Nonogi, H., Marolf, A. P., Grimm, J., Abnormal coronary vasomotion during exercise in patients with normal coronary arteries and reduced coronary flow reserve (1989) Circulation, 79, pp. 516-527
Bergmann, S. R., Fox, K. A., Rand, A. L., McElvany, K. D., Welch, M. J., Markham, J., Quantification of regional myocardial blood flow in vivo with H 2-15O (1984) Circulation, 70, pp. 724-733
Buchthal, S. D., Den Hollander, J. A., Merz, C. N., Rogers, W. J., Pepine, C. J., Reichek, N., Abnormal myocardial phosphorus-31 nuclear magnetic resonance spectroscopy in women with chest pain but normal coronary angiograms (2000) N Engl J Med, 342, pp. 829-835
Camici, P. G., Marraccini, P., Gistri, R., Salvadori, P. A., Sorace, O., L'Abbate, A., Adrenergically mediated coronary vasoconstriction in patients with syndrome X (1994) Cardiovasc Drugs Ther, 8, pp. 221-226
Lanza, G. A., Giordano, A., Pristipino, C., Calcagni, M. L., Meduri, G., Trani, C., Abnormal cardiac adrenergic nerve function in patients with syndrome X detected by [123I] metaiodobenzylguanidine myocardial scintigraphy (1997) Circulation, 96, pp. 821-826
Botker, H. E., Sonne, H. S., Bagger, J. P., Nielsen, T. T., Impact of impaired coronary flow reserve and insulin resistance on myocardial energy metabolism in patients with syndrome X (1997) Am J Cardiol, 79, pp. 1615-1622
Buus, N. H., Bottcher, M., Hermansen, F., Sander, M., Nielsen, T. T., Mulvany, M. J., Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia (2001) Circulation, 104, pp. 2305-2310
Assessment of coronary flow reserve by sestamibi imaging in patients with typical chest pain and normal coronary arteries
PURPOSE: We assessed coronary flow reserve (CFR) by sestamibi imaging in patients with typical chest pain, positive exercise stress test and normal coronary vessels.; METHODS: Thirty-five patients with typical chest pain and normal angiogram and 12 control subjects with atypical chest pain underwent dipyridamole/rest (99m)Tc-sestamibi imaging. Myocardial blood flow (MBF) was estimated by measuring first transit counts in the pulmonary artery and myocardial counts from SPECT images. Estimated CFR was expressed as the ratio of stress to rest MBF. Rest MBF and CFR were corrected for rate-pressure product (RPP) and expressed as normalised MBF (MBF(n)) and normalised CFR (CFR(n)). Coronary vascular resistances (CVR) were calculated as the ratio between mean arterial pressure and estimated MBF.; RESULTS: At rest, estimated MBF and MBF(n) were lower in controls than in patients (0.98 +/- 0.4 vs 1.30 +/- 0.3 counts/pixel/s and 1.14 +/- 0.5 vs 1.64 +/- 0.6 counts/pixel/s, respectively, both p < 0.02). Stress MBF was not different between controls and patients (2.34 +/- 0.8 vs 2.01 +/- 0.7 counts/pixel/s, p=NS). Estimated CFR was 2.40 +/- 0.3 in controls and 1.54 +/- 0.3 in patients (p < 0.0001). After correction for the RPP, CFR(n) was still higher in controls than in patients (2.1 +/- 0.5 vs 1.29 +/- 0.5, p < 0.0001). At baseline, CVR values were lower (p < 0.01) in patients than in controls. Dipyridamole-induced changes in CVR were greater (p < 0.0001) in controls (-63%) than in patients (-35%). In the overall study population, a significant correlation between dipyridamole-induced changes in CVR and CFR was observed (r = -0.88, p < 0.0001).; CONCLUSION: SPECT might represent a useful non-invasive method for assessing coronary vascular function in patients with angina and a normal coronary angiogram.
Assessment of coronary flow reserve by sestamibi imaging in patients with typical chest pain and normal coronary arteries
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(496 views) Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 ViewExport to BibTeXExport to EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(694 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote