Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (614 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
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Paper type: Journal Article, Research Support, N. I. H. , Extramural,
Impact factor: 4.906, 5-year impact factor: 4.087
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84878659638&partnerID=40&md5=a854c1a86eac8f0fccf5c51ea258688e
Keywords: Apoptosis Induction, External Beam Radiation, Microbubbles, P130, Prostate Cancer, Retinoblastoma, Systemic Targeted Viral Gene Delivery, Tumor Suppressor Gene, Ultrasound, Adenovirus Vector, Echo Contrast Medium, Protein P130, Retinoblastoma Protein, Animal Experiment, Animal Model, Animal Tissue, Article, Bioluminescence, Bright Field Microscopy, Cancer Inhibition, Cell Death, Controlled Study, Dna Damage, Flow Cytometry, G2 Phase Cell Cycle Checkpoint, Gene Expression, Genetic Transduction, Human, Human Cell, Mouse, Nonhuman, Phase Contrast Microscopy, Polyacrylamide Gel Electrophoresis, Protein Expression, Tumor Volume, Western Blotting, Adenoviridae, Benzothiazoles, Cell Line, Drug Carriers, Drug Delivery Systems, Female, Gene Transfer Techniques, Genetic Therapy, Genetic Vectors, Luminescent Measurements, Inbred Balb C, Prostatic Neoplasms, Retinoblastoma-Like Protein P130, Transgenes, Ultrasonography, X-Rays, Xenograft Model Antitumor Assays, Mus Musculus,
Affiliations:
*** IBB - CNR ***
Department of Biochemistry and Microbiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.
Department of Biomorphological and Functional Science, University of Naples Federico II, Naples, Italy
CEINGE, Biotecnologie Avanzate, s.c.a.r.l, Italy
Department of Radiation Oncology, Tri-State Regional Cancer Center, Ashland, KY, United States
Urology Department, National Cancer Institute Fondazione Senatore Pascale, Naples, Italy
Department of Surgery, Marshall University, Huntington, WV 25755, United States
References:
Not available.
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, N. I. H. , Extramural,
Impact factor: 4.906, 5-year impact factor: 4.087
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84878659638&partnerID=40&md5=a854c1a86eac8f0fccf5c51ea258688e
Keywords: Apoptosis Induction, External Beam Radiation, Microbubbles, P130, Prostate Cancer, Retinoblastoma, Systemic Targeted Viral Gene Delivery, Tumor Suppressor Gene, Ultrasound, Adenovirus Vector, Echo Contrast Medium, Protein P130, Retinoblastoma Protein, Animal Experiment, Animal Model, Animal Tissue, Article, Bioluminescence, Bright Field Microscopy, Cancer Inhibition, Cell Death, Controlled Study, Dna Damage, Flow Cytometry, G2 Phase Cell Cycle Checkpoint, Gene Expression, Genetic Transduction, Human, Human Cell, Mouse, Nonhuman, Phase Contrast Microscopy, Polyacrylamide Gel Electrophoresis, Protein Expression, Tumor Volume, Western Blotting, Adenoviridae, Benzothiazoles, Cell Line, Drug Carriers, Drug Delivery Systems, Female, Gene Transfer Techniques, Genetic Therapy, Genetic Vectors, Luminescent Measurements, Inbred Balb C, Prostatic Neoplasms, Retinoblastoma-Like Protein P130, Transgenes, Ultrasonography, X-Rays, Xenograft Model Antitumor Assays, Mus Musculus,
Affiliations:
*** IBB - CNR ***
Department of Biochemistry and Microbiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.
Department of Biomorphological and Functional Science, University of Naples Federico II, Naples, Italy
CEINGE, Biotecnologie Avanzate, s.c.a.r.l, Italy
Department of Radiation Oncology, Tri-State Regional Cancer Center, Ashland, KY, United States
Urology Department, National Cancer Institute Fondazione Senatore Pascale, Naples, Italy
Department of Surgery, Marshall University, Huntington, WV 25755, United States
References:
Not available.
Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer
Combining radiation therapy and direct intratumoral (IT) injection of adenoviral vectors has been explored as a means to enhance the therapeutic potential of gene transfer. A major challenge for gene transfer is systemic delivery of nucleic acids directly into an affected tissue. Ultrasound (US) contrast agents (microbubbles) are viable candidates to enhance targeted delivery of systemically administered genes. Here we show that p53, pRB, and p130 gene transfer mediated by US cavitation of microbubbles at the tumor site resulted in targeted gene transduction and increased reduction in tumor growth compared to DU-145 prostate cancer cell xenografts treated intratumorally with adenovirus (Ad) or radiation alone. Microbubble-assisted/US-mediated Ad.p53 and Ad.RB treated tumors showed significant reduction in tumor volume compared to Ad.p130 treated tumors (p
Combining radiation therapy and direct intratumoral (IT) injection of adenoviral vectors has been explored as a means to enhance the therapeutic potential of gene transfer. A major challenge for gene transfer is systemic delivery of nucleic acids directly into an affected tissue. Ultrasound (US) contrast agents (microbubbles) are viable candidates to enhance targeted delivery of systemically administered genes. Here we show that p53, pRB, and p130 gene transfer mediated by US cavitation of microbubbles at the tumor site resulted in targeted gene transduction and increased reduction in tumor growth compared to DU-145 prostate cancer cell xenografts treated intratumorally with adenovirus (Ad) or radiation alone. Microbubble-assisted/US-mediated Ad.p53 and Ad.RB treated tumors showed significant reduction in tumor volume compared to Ad.p130 treated tumors (p
Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer
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Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer
Other filter: ([btitle,keywords] "Apoptosis Induction" ...
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Impact Factor: 1.304
View Export to BibTeX Export to EndNote
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* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (505 views)
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Impact Factor: 4.784
View Export to BibTeX Export to EndNote
D'Amora A, Cucciolito M, E , Iannitti R, Morelli G, Palumbo R, Ruffo F, Tesauro D
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Impact Factor: 2.606
View Export to BibTeX Export to EndNote
Roviello GN, Iannitti R, Palumbo R, Simonyan H, Vicidomini C, Roviello V
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Impact Factor: 2.906
View Export to BibTeX Export to EndNote
Roviello GN, Iannitti R, Roviello V, Palumbo R, Simonyan H, Vicidomini C
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 2.466
View Export to BibTeX Export to EndNote
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Impact Factor: 2.376
View Export to BibTeX Export to EndNote
Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
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Impact Factor: 3.65
View Export to BibTeX Export to EndNote
Cella L, D'Avino V, Liuzzi R, Conson M, Doria F, Faiella A, Loffredo F, Salvatore M, Pacelli R
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Impact Factor: 2.36
View Export to BibTeX Export to EndNote
Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
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Impact Factor: 0.983
View Export to BibTeX Export to EndNote
Storto G, Gallicchio R, Pellegrino T, Nardelli A, Capacchione D, Sirignano C, Pace L
* Impact of F-18-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP (452 views) (PDF 30 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897, 0969-8051linking), 2013 May; 40(4): 518-523.
Impact Factor: 2.408
View Export to BibTeX Export to EndNote
Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (1086 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
View Export to BibTeX Export to EndNote
Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (468 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
View Export to BibTeX Export to EndNote
De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (1147 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
View Export to BibTeX Export to EndNote
Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (472 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
View Export to BibTeX Export to EndNote
Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (638 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (542 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
View Export to BibTeX Export to EndNote
Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (676 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
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J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (476 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
View Export to BibTeX Export to EndNote
Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (396 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
View Export to BibTeX Export to EndNote
Cella L, Lomax A, Miralbell R
* New techniques in hadrontherapy: Intensity modulated proton beams (338 views)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 2001; 17(SUPPL.1): 100-102.
Impact Factor: 0.556
View Export to BibTeX Export to EndNote
Cella L, Lomax A, Miralbell R
* Potential role of intensity modulated proton beams in prostate cancer radiotherapy (460 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2001; 49(1): 217-223.
Impact Factor: 3.327
View Export to BibTeX Export to EndNote
25 Records (23 excluding Abstracts).
Total impact factor: 62.753 (56.881 excluding Abstracts).
Total 5 year impact factor: 65.486 (58.3 excluding Abstracts).
Total impact factor: 62.753 (56.881 excluding Abstracts).
Total 5 year impact factor: 65.486 (58.3 excluding Abstracts).
614 views. Last view on Friday 20 September 2024, 8:06:49
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