Determinants of physiologic 18F-FDG uptake in brown adipose tissue in sequential PET/CT examinations(462 views) Pace L, Nicolai E, D'Amico D, Ibello F, Della Morte AM, Salvatore B, Pizzuti LM, Salvatore M, Soricelli A
Keywords: 18f-Fdg, Brown Adipose Tissue, Pet Ct, Fluorodeoxyglucose F 18, Adolescent, Adult, Aged, Article, Body Mass, Computer Assisted Emission Tomography, Controlled Study, Female, Human, Image Analysis, Low Temperature, Metabolic Activation, Priority Journal, Radioactivity, Radioisotope Distribution, Repeat Procedure, Retrospective Study, Sex Difference, Soft Tissue, Standardization, Temperature Measurement, Tissue Distribution, Middle Aged, Radiography, Scintiscanning, 80 And Over, Positron-Emission Tomography And Computed Tomography, Young Adult,
Affiliations: *** IBB - CNR ***
Dipartimento di Scienze Biomorfologiche e Funzionali, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Napoli, Italy. pace@unina.it
Instituto di Biostrutture e Bioimmagini, C.N.R., Naples, Italy
Fondazione SDN-IRCCS, Naples, Italy
References: Barrington, S.F., Maisey, M.N., Skeletal muscle uptake of fluorine-18-FDG: Effect of oral diazepam (1996) Journal of Nuclear Medicine, 37 (7), pp. 1127-112
Clarke, J.R., Brglevska, S., Lau, E.W.F., Ramdave, S., Hicks, R.J., Atypical brown fat distribution in young males demonstrated on PET/CT (2007) Clinical Nuclear Medicine, 32 (9), pp. 679-682. , DOI 10.1097/RLU.0b013e318126c01c, PII 0000307220070900000001
Yeung, H.W.D., Grewal, R.K., Gonen, M., Schoder, H., Larson, S.M., Patterns of 18F-FDG uptake in adipose tissue and muscle: A potential source of false-positives for PET (2003) Journal of Nuclear Medicine, 44 (11), pp. 1789-1796
Hany, T.F., Gharehpapagh, E., Kamel, E.M., Buck, A., Himms-Hagen, J., Von Schulthess, G.K., Brown adipose tissue: A factor to consider in symmetrical tracer uptake in the neck and upper chest region (2002) European Journal of Nuclear Medicine and Molecular Imaging, 29 (10), pp. 1393-1398. , DOI 10.1007/s00259-002-0902-6
Cohade, C., Osman, M., Pannu, H.K., Wahl, R.L., Uptake in supraclavicular area fat ("USA-Fat"): Description on 18F-FDG PET/ CT (2003) J Nucl Med, 44, pp. 170-176
Kim, S.H., Kryncycky, B.R., Machac, J., Kim, C.K., Temporal relation between temperature change and FDG uptake in brown adipose tissue (2008) Eur J Nucl Med Mol Imaging, 35, pp. 984-989
Tatsumi, M., Engles, J.M., Ishimori, T., Nicely, O'B., Cohade, C., Wahl, R.L., Intense 18F-FDG uptake in brown fat can be reduced pharmacologically (2004) Journal of Nuclear Medicine, 45 (7), pp. 1189-1193. , http://jnm.snmjournals.org/cgi/reprint/45/7/1189
Zukotynski, J.A., Fahey, F.H., Laffin, S., Davis, R., Treves, S.T., Grant, F.D., Drubach, L.A., Constant ambient temperature of 24°C significantly reduces FDG uptake by brown adipose tissue in children scanned during the winter (2009) Eur J Nucl Med Mol Imaging, 36, pp. 602-606
Baba, S., Tatsumi, M., Ishimori, T., Liliein, D.L., Engles, J.M., Wahl, R.L., Effect of nicotine and ephedrine on the accumulation of 18F-FDG in brown adipose tissue (2007) Journal of Nuclear Medicine, 48 (6), pp. 981-986. , DOI 10.2967/jnumed.106.039065
Gelfand, M.J., O'Hara, S.M., Curtwright Lois, A.L.A., MacLean, J.R., Pre-medication to block [ 18F]FDG uptake in the brown adipose tissue of pediatric and adolescent patients (2005) Pediatric Radiology, 35 (10), pp. 984-990. , DOI 10.1007/s00247-005-1505-8
Parysow, O., Mollerach, A.M., Jager, V., Racioppi, S., Roman, J.S., Gerbaudo, V.H., Low-dose oral propranolol could reduce brown adipose tissue F-18 FDG uptake in patients undergoing PET scans (2007) Clinical Nuclear Medicine, 32 (5), pp. 351-357. , DOI 10.1097/01.rlu.0000259570.69163.04, PII 0000307220070500000001
Soderlund, V., Larsson, S.A., Jacobsson, H., Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol (2007) European Journal of Nuclear Medicine and Molecular Imaging, 34 (7), pp. 1018-1022. , DOI 10.1007/s00259-006-0318-9
Garcia, C.A., Van Nostrand, D., Atkins, F., Acio, E., Butler, C., Esposito, G., Kulkarni, K., Majd, M., Reduction of brown fat 2-deoxy-2-[F-18]fluoro-D-glucose uptake by controlling environmental temperature prior to positron emission tomography scan (2006) Molecular Imaging and Biology, 8 (1), pp. 24-29. , DOI 10.1007/s11307-005-0030-3
Christensen, C.R., Clark, P.B., Morton, K.A., Reversal of hypermetabolic brown adipose tissuein F-18 FDG PET imaging (2006) Clinical Nuclear Medicine, 31 (4), pp. 193-196. , DOI 10.1097/01.rlu.0000204199.33136.05, PII 0000307220060400000002
Van Marken Lichtenbelt, W.D., Vanhommerig, J.W., Smulders, N.M., Drossaerts, J.M.A.F.L., Kemerink, G.J., Bouvy, N.D., Schrauwen, P., Jaap Teule, G.J., Cold-activated brown adipose tissue in healthy men (2009) N Engl J Med, 360, pp. 1500-1508
Virtanen, K.A., Lidell, M.E., Janne Orava, J., Heglind, M., Westergren, R., Tarja Niemi, T., Taittonen, M., Nuutila, P., Functional brown adipose tissue in healthy adults (2009) N Engl J Med, 360, pp. 1518-1525
Cypess, A.M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A.B., Kuo, F.C., Kahn, C.R., Identification and importance of brown adipose tissue in adult humans (2009) N Engl J Med, 360, pp. 1509-1517
Dobert, N., Menzel, C., Hamscho, N., Wordehoff, N., Kranert, W.T., Grunwald, F., Atypical thoracic and supraclavicular FDG-uptake in patients with Hodgkin's and non-Hodgkin's lymphoma (2004) Quarterly Journal of Nuclear Medicine and Molecular Imaging, 48 (1), pp. 33-38
Rousseau, C., Bourbouloux, E., Campion, L., Fleury, N., Bridji, B., Chatal, J.F., Resche, I., Campone, M., Brown fat in breast cancer patients: Analysis of serial 18F-FDG PET/CT scans (2006) European Journal of Nuclear Medicine and Molecular Imaging, 33 (7), pp. 785-791. , DOI 10.1007/s00259-006-0066-x
Truong, M.T., Erasmus, J.J., Munden, R.F., Marom, E.M., Sabloff, B.S., Gladish, G.W., Podoloff, D.A., Macapinlac, H.A., Focal FDG uptake in mediastinal brown fat mimicking malignancy: A potential pitfall resolved on PET/CT (2004) American Journal of Roentgenology, 183 (4), pp. 1127-1132
Cohade, C., Mourtzikos, K.A., Wahl, R.L., "USA-Fat": Prevalence is related to ambient outdoor temperature - Evaluation with 18F-FDG PET/CT (2003) Journal of Nuclear Medicine, 44 (8), pp. 1267-1270
Cannon, B., Nedergaard, J., Brown adipose tissue: Function and physiological significance (2004) Physiological Reviews, 84 (1), pp. 277-359. , DOI 10.1152/physrev.00015.2003
Williams, G., Kolodny, G.M., Method for decreasing uptake of 18F-FDG by hypermetabolic brown adipose tissue on PET (2008) American Journal of Roentgenology, 190 (5), pp. 1406-1409. , http://www.ajronline.org/cgi/reprint/190/5/1406, DOI 10.2214/AJR.07.3205
Sturkenboom, M.G.G., Hoekstra, O.S., Postema, E.J., Zijlstra, J.M., Berkhof, J., Franssen, E.J.F., A randomized controlled trial assessing the effect of oral diazepam on 18F-FDG uptake in the neck and upper chest region (2009) Mol Imaging Biol, 11, pp. 364-368
Cohade, C., Altered biodistribution on FDG-PET with emphasis on brown fat and insulin effect (2010) Semin Nucl Med, 40, pp. 283-293
Determinants of physiologic 18F-FDG uptake in brown adipose tissue in sequential PET/CT examinations
PURPOSE: The aim of this study was to assess independent predictors of 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)F-FDG) uptake in brown adipose tissue (BAT) in patients undergoing repeated positron emission tomography (PET)/computed tomography (CT) scans.; PROCEDURES: Eight hundred forty-eight (mean age 50.9±16 years) patients in whom PET/CT scan was repeated (mean interval 5±1.5 months) constituted the study group. (18)F-FDG uptake in characteristic areas of BAT, with CT density of adipose tissue, greater than background soft-tissue activity was considered as evidence of BAT uptake. Both distribution and maximum standardized uptake values (SUVmax) were registered. Clinical and anamnestic data were collected for each patient.; RESULTS: (18)F-FDG uptake in BAT was present in 8.6% patients at first scan. Independent predictors of presence of uptake were age (younger), gender (female), body mass index (lower), and maximum outdoor temperature (lower). Age was the only independent predictor of BAT (18)F-FDG uptake distribution, while SUVmax was related to both age and outdoor temperature. Independent determinants of persistence of BAT (18)F-FDG uptake at second PET/CT were outdoor temperature at time of second scan and extension of metabolically active BAT at first scan.; CONCLUSIONS: Age, body mass index, and outdoor temperature are significant determinants of BAT evidence at (18)F-FDG PET/CT. Moreover, extension of BAT and outdoor temperature are the strongest determinants of persistence of BAT evidence on (18)F-FDG PET/CT in repeated scan.
Determinants of physiologic 18F-FDG uptake in brown adipose tissue in sequential PET/CT examinations
No results.
Determinants of physiologic 18F-FDG uptake in brown adipose tissue in sequential PET/CT examinations
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(284 views) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 ViewExport to BibTeXExport to EndNote
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(297 views) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 ViewExport to BibTeXExport to EndNote
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(349 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote
Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G * Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation(849 views) Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806. Impact Factor:8.017 ViewExport to BibTeXExport to EndNote
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(449 views) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 ViewExport to BibTeXExport to EndNote
Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S * Fusion in Coq(479 views) Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596. Impact Factor:0.415 ViewExport to BibTeXExport to EndNote