Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster(1118 views) Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Keywords: Alzheimer, S Disease, Carnosine, Molecular Dynamics, Neuroprotective Agent, Nutraceutical Compounds, Protein-Protein Interactions, Amyloid, Amyloid Beta Protein[1-42], Collagen Fibril, Heptapeptide, Monomer, Thioflavine, Alzheimer Disease, Article, Circular Dichroism, Controlled Study, Drug Mechanism, Experimentation, Fluorescence Analysis, Hydrogen Bond, Hydrophobicity, Nuclear Magnetic Resonance, Priority Journal, Protein Aggregation, Protein Conformation, Protein Structure, Scanning Force Microscopy, Amyloid Beta-Peptides, Hydrogen Bonding, Hydrophobic And Hydrophilic Interactions, Magnetic Resonance Spectroscopy, Molecular Dynamics Simulation, Peptide Fragments, Static Electricity, Temperature, Amyloid Beta-Peptides Antagonists, Inhibitors Metabolism, Carnosine Chemistry Metabolism, Peptide Fragments Antagonists, Amyloid Beta Protein [1-42],
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini-UOS CT, Consiglio Nazionale delle Ricerche, V.le A. Doria 6, 95125 Catania, Italy
Biochemisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland
Dipartimento di Scienze Mediche e Biologiche, Università di Udine, Piazzale Kolbe 4, 33100 Udine, Italy
Dipartimento di Fisica e Chimica, Università di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy
References: Not available.
Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster