Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation(688 views) Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
Department of Experimental Medicine, Sapienza University, 324 viale Regina Elena, 00161 Rome, Italy.
Department of Biochemical Sciences, Sapienza University, 324 viale Regina Elena, 00161 Rome, Italy
IRBM-Merck Research Laboratories Rome, 00040 Pomezia, Italy
Neuromed Institute, 86077 Pozzilli, Italy
Institute of Biostructures and Bioimaging, CNR, 80134 Napoli, Italy
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Huntzicker, E. G., Dual degradation signals control Gli protein stability and tumor formation (2006) Genes Dev., 20, pp. 276-281
Glozak, M. A., Sengupta, N., Zhang, X., Seto, E., Acetylation and deacetylation of non-histone proteins (2005) Gene, 363, pp. 15-23
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Yoon, J. W., GLI activates transcription through a herpes simplex viral protein 16-like activation domain (1998) J. Biol. Chem., 273, pp. 3496-3501
Chen, J. K., Taipale, J., Young, K. E., Maiti, T., Beachy, P. A., (2002) Small Molecule Modulation of Smoothened Activity. Proc. Natl Acad. Sci. USA, 99, pp. 14071-14076
Cheng, S. Y., Bishop, J. M., Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex (2002) Proc. Natl Acad. Sci. USA, 99, pp. 5442-5447
Goodrich, L. V., Milenkovic, L., Higgins, K. M., Scott, M. P., Altered neural cell fates and medulloblastoma in mouse patched mutants (1997) Science, 277, pp. 1109-1113
Bar, E. E., Chaudhry, A., Farah, M. H., Eberhart, C. G., Hedgehog signaling promotes medulloblastoma survival via Bc/II (2007) Am. J. Pathol., 170, pp. 347-355
Montgomery, R. L., Hsieh, J., Barbosa, A. C., Richardson, J. A., Olson, E. N., Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development (2009) Proc. Natl Acad. Sci. USA, 106, pp. 7876-7881
Shak d, M., Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling (2008) PLoS One, 3, pp. e2668
Cunliffe, V. T., Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling (2004) Development, 131, pp. 2983-2995
Kim, J. E., Chen, J., Lou, Z., DBC1 is a negative regulator of SIRT1 (2008) Nature, 451, pp. 583-586
Spiller, S. E., Ravanpay, A. C., Hahn, A. W., Olson, J. M., Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma (2006) J. Neurooncol., 79, pp. 259-270
Scales, S. J., De Sauvage, F. J., Mechanisms of Hedgehog pathway activation in cancer and implications for therapy (2009) Trends Pharmacol. Sci., 30, pp. 303-312
Chun, S. G., Zhou, W., Yee, N. S., Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer (2009) Cancer Biol. Ther., 8, pp. 1328-1339
Gu, W., Roeder, R. G., Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain (1997) Cell, 90, pp. 595-606
Pappin, D. J., Peptide mass fingerprinting using MALDI-TOF mass spectrometry (2003) Methods Mol. Biol., 211, pp. 211-219
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
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