Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (698 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 1.807, 5-year impact factor: 1.872
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449141261&partnerID=40&md5=a110f35d3d897508022822a3f1e832da
Keywords: β-Sheet Breaker Peptides, Amyloid-β, Neuronal Cultures, Thioflavin T, Trehalose, Amyloid Beta Protein[1-42], Pentapeptide, Animal Cell, Animal Tissue, Article, Brain Nerve Cell, Controlled Study, Drug Conformation, Drug Design, Drug Mechanism, Drug Structure, Drug Synthesis, Embryo, Nerve Cell Culture, Nonhuman, Priority Journal, Protein Aggregation, Protein Assembly, Atomic Force Microscopy, Brain Cortex, Cell Survival, Chemistry, Cytology, Drug Effect, High Performance Liquid Chromatography, Mass Spectrometry, Rattus, Cerebral Cortex, High Pressure Liquid, ß-Sheet Breaker Peptides, Amyloid Beta Protein [1-42], Chemical Synthesis, Pharmacology,
Affiliations:
*** IBB - CNR ***
University of Catania, Department of Chemical Sciences, 95125 Catania, Italy
National Research Council, Institute of Biostructures and Bioimaging, 95125 Catania, Italy
University of Palermo, Department of Physical Chemistry F. Accascina, 90133 Palermo, Italy
References:
Selkoe, D.J., The molecular pathology of Alzheimer's disease (1991) Neuron, 6, pp. 487-49
Pike, C.J., Burdick, D., Walencewicz, A.J., Glabe, C.G., Cotman, C.W., Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state (1993) J. Neurosci, 13, pp. 1676-1687
Seilheimer, B., Bohrmann, B., Bondolfi, L., Muller, F., Stuber, D., Dobeli, H., The toxicity of the Alzheimer's β-amyloid peptide correlates with a distinct fiber morphology (1997) J. Struct. Biol, 119, pp. 59-71
Simmons, L.K., May, P.C., Tommaselli, K.J., Rydel, R.E., Fuson, K.S., Brigham, E.F., Wright, S., Brems, D.N., Secondary structure of amyloid β peptide correlates with neurotoxic activity in vitro (1994) Mol. Pharmacol, 45, pp. 373-379
Standridge, J.B., Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease (2006) Curr. Alzheimer Res, 3, pp. 95-108
McLean, C.A., Chemy, R.A., Fraser, F.W., Fuller, S.J., Smith, M.J., Beyreuther, K., Bush, A.I., Masters, C.L., Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease (1999) Ann. Neurol, 46, pp. 860-866
Shankar, G.M., Bloodgood, B.L., Townsend, M., Walsh, D.M., Selkoe, D.J., Sabatini, B.L., Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway (2007) J. Neurosci, 27, pp. 2866-2875
Sciarretta, K.L., Gordon, D.J., Meredith, S., Peptide-based inhibitors of amyloid assembly (2006) Methods Enzymol, 413, pp. 273-312
Tjernberg, L.O., Naslund, J., Lindqvist, F., Johansson, J., Karlstrom, A.R., Thyberg, J., Terenius, L., Nordstedt, C., Arrest of β-amyloid fibril formation by a pentapeptide ligand (1996) J. Biol. Chem, 271, pp. 8545-8548
Gibson, T.J., Murphy, R.M., Design of peptidyl compounds that affect β-amyloid aggregation: Importance of surface tension and context (2005) Biochemestry, 44, pp. 8898-8907
Findeis, M.A., Lee, J.-D., Kelley, M., Wakefield, J.D., Zhang, M.-H., Chin, J., Kubasek, W., Molineaux, S.M., Characterization of cholyl-leu-val-phephe-ala-OH as an inhibitor of amyloid beta-peptide polymerization (2001) Amyloid, 8, pp. 231-241
Hughes, E., Burke, R.M., Doig, A.J., Inhibition of toxicity in the peptide fragment β-(25-35) using N-methylated derivatives. A general strategy to prevent amyloid formation (2000) J. Biol. Chem, 275, pp. 25209-25115
Gordon, D.J., Tappe, R., Meredith, S.C., Design and characterization of a membrane permeable N-methyl amino acid containing peptide that inhibits Aβ1-40 fibrillogenesis (2002) J. Pept. Res, 60, pp. 37-55
Soto, C., Kindy, M.S., Baumann, M., Frangione, B., Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation (1996) Biochem. Biophys. Res. Commun, 226, pp. 672-680
Permanne, B., Adessi, C., Saborio, G.P., Fraga, S., Frossard, M.-J., Van Dorpe, J., Dewachter, I., Soto, C., Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with β-sheet breaker peptide (2002) FASEB J, 16, pp. 860-862
Chacon, M.A., Barria, M.I., Soto, C., Inestrosa, N.C., β-sheet breaker peptide prevents Aβ-induced spatial memory impairments with partial reduction of amyloid deposits (2004) Mol. Psychiatry, 9, pp. 953-961
Adessi, C., Frossard, M.-J., Boissard, C., Fraga, S., Bieler, S., Ruckle, T., Vilbois, F., Soto, C., Pharmacological profile of peptide drug candidates for the treatment of Alzheimer's disease (2003) J. Biol. Chem, 278, pp. 13905-13911
Nitz, M., Fenili, D., Darabie, A.A., Wu, L., Cousins, J.E., McLaurin, J., Modulation of amyloid-β aggregation and toxicity by inosose stereoisomers (2008) FEBS J, 275, pp. 1663-1674
Liu, R., Barkhordarian, H., Emadi, S., Park, C.B., Sierks, M.R., Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42 (2005) Neurobiol. Dis, 20, pp. 74-81
Cucinotta, V., Giuffrida, A., Maccarrone, G., Messina, M., Puglisi, A., Vecchio, G., Synthesis and NMR characterization of β-alanine-bridged hemispherodextrin, a very efficient chiral selector in EKC (2007) Electroforesis, 28, pp. 2580-2588
Kates, S.A., Solè, N.A., Johnson, C.R., Hudson, D., Barany, G., Albericio, F., A novel, convenient, three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides (1993) Tetrahedron Lett, 34, pp. 1549-1552
O'Nuallain, B., Thakur, A.K., Williams, A.D., Bhattachatyya, A.M., Chen, S., Thiagarajan, G., Wetzel, R., Kinetics and thermodynamics of amyloid assembly using a high-performance liquid chromatography-based sedimentation assay (2006) Methods Enzymol, 43, pp. 34-74
Zagorski, M.G., Yang, J., Shao, H., Ma, K., Zeng, H., Hong, A., Methodological and chemical factors affecting amyloi-β amyloidogenicity (1999) Methods Enzymol, 309, pp. 189-204
Naiki, H., Higuchi, K., Hosokawa, M., Takeda, T., Fluorimetric determination of amyloid fibrils in vitro using the fluorescence dye, thioflavine T (1989) Anal. Biochem, 177, pp. 244-249
LeVine III, H., Quantification of beta-sheet amyloid fibril structures with thioflavine T (1999) Methods Enzymol, 309, pp. 274-284
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Pignataro, B., Sardone, L., Marletta, G., Dynamic scanning force microscopy investigation of nanostructured spiral-like domains in Langmuir-Blodgettmonolayers (2003) Nanotechnology, 14, pp. 245-249
Tilstra, L., Mattice, W.L., The β sheet = coil transition of polypeptides, as determined by circular dichroism (1996) Circular Dichroism and the Conformational Analysis of Biomolecules, pp. 261-283. , Fasman GD ed, Plenum Press: New York and London
Blackley, H.K., Sanders, G.H., Davies, M.C., Roberts, C.J., Tendler, S.J., Wilkinson, M.J., In-situ atomic force microscopy study of beta-amyloid fibrillization (2000) J. Mol. Biol, 298, pp. 833-840
Arimon, M., Díez-Péerez, I., Kogan, M.J., Durany, N., Giralt, E., Sanz, F., Fernàndez-Busquets, X., Fine structure study ofAβ1-42 fibrillogenesis with atomic forcemicroscopy (2005) FASEB J, 19, pp. 1344-1346
McLaurin, J., Kierstead, M.E., Brown, M.E., Hawkes, C.A., Lambermon, M.H., Phinney, A.L., Darabie, A.A., St George-Hyslop, P., Cyclohexanehoxol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mousemodel (2006) Nat. Med, 12, pp. 801-808
Laczko, I., Vass, E., Soòs, K., Fulop, L., Zarandi, M., Penke, B., Aggregation of Abeta(1-42) in the presence of short peptides: Conformational studies (2008) J. Pept. Sci, 14, pp. 731-741
Selkoe, D. J., The molecular pathology of Alzheimer's disease (1991) Neuron, 6, pp. 487-49
Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., Cotman, C. W., Neurodegeneration induced by -amyloid peptides in vitro: The role of peptide assembly state (1993) J. Neurosci, 13, pp. 1676-1687
Simmons, L. K., May, P. C., Tommaselli, K. J., Rydel, R. E., Fuson, K. S., Brigham, E. F., Wright, S., Brems, D. N., Secondary structure of amyloid peptide correlates with neurotoxic activity in vitro (1994) Mol. Pharmacol, 45, pp. 373-379
Standridge, J. B., Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease (2006) Curr. Alzheimer Res, 3, pp. 95-108
McLean, C. A., Chemy, R. A., Fraser, F. W., Fuller, S. J., Smith, M. J., Beyreuther, K., Bush, A. I., Masters, C. L., Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease (1999) Ann. Neurol, 46, pp. 860-866
Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., Sabatini, B. L., Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway (2007) J. Neurosci, 27, pp. 2866-2875
Sciarretta, K. L., Gordon, D. J., Meredith, S., Peptide-based inhibitors of amyloid assembly (2006) Methods Enzymol, 413, pp. 273-312
Tjernberg, L. O., Naslund, J., Lindqvist, F., Johansson, J., Karlstrom, A. R., Thyberg, J., Terenius, L., Nordstedt, C., Arrest of -amyloid fibril formation by a pentapeptide ligand (1996) J. Biol. Chem, 271, pp. 8545-8548
Gibson, T. J., Murphy, R. M., Design of peptidyl compounds that affect -amyloid aggregation: Importance of surface tension and context (2005) Biochemestry, 44, pp. 8898-8907
Findeis, M. A., Lee, J. -D., Kelley, M., Wakefield, J. D., Zhang, M. -H., Chin, J., Kubasek, W., Molineaux, S. M., Characterization of cholyl-leu-val-phephe-ala-OH as an inhibitor of amyloid beta-peptide polymerization (2001) Amyloid, 8, pp. 231-241
Gordon, D. J., Tappe, R., Meredith, S. C., Design and characterization of a membrane permeable N-methyl amino acid containing peptide that inhibits A 1-40 fibrillogenesis (2002) J. Pept. Res, 60, pp. 37-55
Chacon, M. A., Barria, M. I., Soto, C., Inestrosa, N. C., -sheet breaker peptide prevents A -induced spatial memory impairments with partial reduction of amyloid deposits (2004) Mol. Psychiatry, 9, pp. 953-961
Kates, S. A., Sol, N. A., Johnson, C. R., Hudson, D., Barany, G., Albericio, F., A novel, convenient, three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides (1993) Tetrahedron Lett, 34, pp. 1549-1552
Zagorski, M. G., Yang, J., Shao, H., Ma, K., Zeng, H., Hong, A., Methodological and chemical factors affecting amyloi- amyloidogenicity (1999) Methods Enzymol, 309, pp. 189-204
Blackley, H. K., Sanders, G. H., Davies, M. C., Roberts, C. J., Tendler, S. J., Wilkinson, M. J., In-situ atomic force microscopy study of beta-amyloid fibrillization (2000) J. Mol. Biol, 298, pp. 833-840
Arimon, M., D ez-P erez, I., Kogan, M. J., Durany, N., Giralt, E., Sanz, F., Fern ndez-Busquets, X., Fine structure study ofA 1-42 fibrillogenesis with atomic forcemicroscopy (2005) FASEB J, 19, pp. 1344-1346
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 1.807, 5-year impact factor: 1.872
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-63449141261&partnerID=40&md5=a110f35d3d897508022822a3f1e832da
Keywords: β-Sheet Breaker Peptides, Amyloid-β, Neuronal Cultures, Thioflavin T, Trehalose, Amyloid Beta Protein[1-42], Pentapeptide, Animal Cell, Animal Tissue, Article, Brain Nerve Cell, Controlled Study, Drug Conformation, Drug Design, Drug Mechanism, Drug Structure, Drug Synthesis, Embryo, Nerve Cell Culture, Nonhuman, Priority Journal, Protein Aggregation, Protein Assembly, Atomic Force Microscopy, Brain Cortex, Cell Survival, Chemistry, Cytology, Drug Effect, High Performance Liquid Chromatography, Mass Spectrometry, Rattus, Cerebral Cortex, High Pressure Liquid, ß-Sheet Breaker Peptides, Amyloid Beta Protein [1-42], Chemical Synthesis, Pharmacology,
Affiliations:
*** IBB - CNR ***
University of Catania, Department of Chemical Sciences, 95125 Catania, Italy
National Research Council, Institute of Biostructures and Bioimaging, 95125 Catania, Italy
University of Palermo, Department of Physical Chemistry F. Accascina, 90133 Palermo, Italy
References:
Selkoe, D.J., The molecular pathology of Alzheimer's disease (1991) Neuron, 6, pp. 487-49
Pike, C.J., Burdick, D., Walencewicz, A.J., Glabe, C.G., Cotman, C.W., Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state (1993) J. Neurosci, 13, pp. 1676-1687
Seilheimer, B., Bohrmann, B., Bondolfi, L., Muller, F., Stuber, D., Dobeli, H., The toxicity of the Alzheimer's β-amyloid peptide correlates with a distinct fiber morphology (1997) J. Struct. Biol, 119, pp. 59-71
Simmons, L.K., May, P.C., Tommaselli, K.J., Rydel, R.E., Fuson, K.S., Brigham, E.F., Wright, S., Brems, D.N., Secondary structure of amyloid β peptide correlates with neurotoxic activity in vitro (1994) Mol. Pharmacol, 45, pp. 373-379
Standridge, J.B., Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease (2006) Curr. Alzheimer Res, 3, pp. 95-108
McLean, C.A., Chemy, R.A., Fraser, F.W., Fuller, S.J., Smith, M.J., Beyreuther, K., Bush, A.I., Masters, C.L., Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease (1999) Ann. Neurol, 46, pp. 860-866
Shankar, G.M., Bloodgood, B.L., Townsend, M., Walsh, D.M., Selkoe, D.J., Sabatini, B.L., Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway (2007) J. Neurosci, 27, pp. 2866-2875
Sciarretta, K.L., Gordon, D.J., Meredith, S., Peptide-based inhibitors of amyloid assembly (2006) Methods Enzymol, 413, pp. 273-312
Tjernberg, L.O., Naslund, J., Lindqvist, F., Johansson, J., Karlstrom, A.R., Thyberg, J., Terenius, L., Nordstedt, C., Arrest of β-amyloid fibril formation by a pentapeptide ligand (1996) J. Biol. Chem, 271, pp. 8545-8548
Gibson, T.J., Murphy, R.M., Design of peptidyl compounds that affect β-amyloid aggregation: Importance of surface tension and context (2005) Biochemestry, 44, pp. 8898-8907
Findeis, M.A., Lee, J.-D., Kelley, M., Wakefield, J.D., Zhang, M.-H., Chin, J., Kubasek, W., Molineaux, S.M., Characterization of cholyl-leu-val-phephe-ala-OH as an inhibitor of amyloid beta-peptide polymerization (2001) Amyloid, 8, pp. 231-241
Hughes, E., Burke, R.M., Doig, A.J., Inhibition of toxicity in the peptide fragment β-(25-35) using N-methylated derivatives. A general strategy to prevent amyloid formation (2000) J. Biol. Chem, 275, pp. 25209-25115
Gordon, D.J., Tappe, R., Meredith, S.C., Design and characterization of a membrane permeable N-methyl amino acid containing peptide that inhibits Aβ1-40 fibrillogenesis (2002) J. Pept. Res, 60, pp. 37-55
Soto, C., Kindy, M.S., Baumann, M., Frangione, B., Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation (1996) Biochem. Biophys. Res. Commun, 226, pp. 672-680
Permanne, B., Adessi, C., Saborio, G.P., Fraga, S., Frossard, M.-J., Van Dorpe, J., Dewachter, I., Soto, C., Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with β-sheet breaker peptide (2002) FASEB J, 16, pp. 860-862
Chacon, M.A., Barria, M.I., Soto, C., Inestrosa, N.C., β-sheet breaker peptide prevents Aβ-induced spatial memory impairments with partial reduction of amyloid deposits (2004) Mol. Psychiatry, 9, pp. 953-961
Adessi, C., Frossard, M.-J., Boissard, C., Fraga, S., Bieler, S., Ruckle, T., Vilbois, F., Soto, C., Pharmacological profile of peptide drug candidates for the treatment of Alzheimer's disease (2003) J. Biol. Chem, 278, pp. 13905-13911
Nitz, M., Fenili, D., Darabie, A.A., Wu, L., Cousins, J.E., McLaurin, J., Modulation of amyloid-β aggregation and toxicity by inosose stereoisomers (2008) FEBS J, 275, pp. 1663-1674
Liu, R., Barkhordarian, H., Emadi, S., Park, C.B., Sierks, M.R., Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42 (2005) Neurobiol. Dis, 20, pp. 74-81
Cucinotta, V., Giuffrida, A., Maccarrone, G., Messina, M., Puglisi, A., Vecchio, G., Synthesis and NMR characterization of β-alanine-bridged hemispherodextrin, a very efficient chiral selector in EKC (2007) Electroforesis, 28, pp. 2580-2588
Kates, S.A., Solè, N.A., Johnson, C.R., Hudson, D., Barany, G., Albericio, F., A novel, convenient, three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides (1993) Tetrahedron Lett, 34, pp. 1549-1552
O'Nuallain, B., Thakur, A.K., Williams, A.D., Bhattachatyya, A.M., Chen, S., Thiagarajan, G., Wetzel, R., Kinetics and thermodynamics of amyloid assembly using a high-performance liquid chromatography-based sedimentation assay (2006) Methods Enzymol, 43, pp. 34-74
Zagorski, M.G., Yang, J., Shao, H., Ma, K., Zeng, H., Hong, A., Methodological and chemical factors affecting amyloi-β amyloidogenicity (1999) Methods Enzymol, 309, pp. 189-204
Naiki, H., Higuchi, K., Hosokawa, M., Takeda, T., Fluorimetric determination of amyloid fibrils in vitro using the fluorescence dye, thioflavine T (1989) Anal. Biochem, 177, pp. 244-249
LeVine III, H., Quantification of beta-sheet amyloid fibril structures with thioflavine T (1999) Methods Enzymol, 309, pp. 274-284
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Pignataro, B., Sardone, L., Marletta, G., Dynamic scanning force microscopy investigation of nanostructured spiral-like domains in Langmuir-Blodgettmonolayers (2003) Nanotechnology, 14, pp. 245-249
Tilstra, L., Mattice, W.L., The β sheet = coil transition of polypeptides, as determined by circular dichroism (1996) Circular Dichroism and the Conformational Analysis of Biomolecules, pp. 261-283. , Fasman GD ed, Plenum Press: New York and London
Blackley, H.K., Sanders, G.H., Davies, M.C., Roberts, C.J., Tendler, S.J., Wilkinson, M.J., In-situ atomic force microscopy study of beta-amyloid fibrillization (2000) J. Mol. Biol, 298, pp. 833-840
Arimon, M., Díez-Péerez, I., Kogan, M.J., Durany, N., Giralt, E., Sanz, F., Fernàndez-Busquets, X., Fine structure study ofAβ1-42 fibrillogenesis with atomic forcemicroscopy (2005) FASEB J, 19, pp. 1344-1346
McLaurin, J., Kierstead, M.E., Brown, M.E., Hawkes, C.A., Lambermon, M.H., Phinney, A.L., Darabie, A.A., St George-Hyslop, P., Cyclohexanehoxol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mousemodel (2006) Nat. Med, 12, pp. 801-808
Laczko, I., Vass, E., Soòs, K., Fulop, L., Zarandi, M., Penke, B., Aggregation of Abeta(1-42) in the presence of short peptides: Conformational studies (2008) J. Pept. Sci, 14, pp. 731-741
Selkoe, D. J., The molecular pathology of Alzheimer's disease (1991) Neuron, 6, pp. 487-49
Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., Cotman, C. W., Neurodegeneration induced by -amyloid peptides in vitro: The role of peptide assembly state (1993) J. Neurosci, 13, pp. 1676-1687
Simmons, L. K., May, P. C., Tommaselli, K. J., Rydel, R. E., Fuson, K. S., Brigham, E. F., Wright, S., Brems, D. N., Secondary structure of amyloid peptide correlates with neurotoxic activity in vitro (1994) Mol. Pharmacol, 45, pp. 373-379
Standridge, J. B., Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease (2006) Curr. Alzheimer Res, 3, pp. 95-108
McLean, C. A., Chemy, R. A., Fraser, F. W., Fuller, S. J., Smith, M. J., Beyreuther, K., Bush, A. I., Masters, C. L., Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease (1999) Ann. Neurol, 46, pp. 860-866
Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., Sabatini, B. L., Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway (2007) J. Neurosci, 27, pp. 2866-2875
Sciarretta, K. L., Gordon, D. J., Meredith, S., Peptide-based inhibitors of amyloid assembly (2006) Methods Enzymol, 413, pp. 273-312
Tjernberg, L. O., Naslund, J., Lindqvist, F., Johansson, J., Karlstrom, A. R., Thyberg, J., Terenius, L., Nordstedt, C., Arrest of -amyloid fibril formation by a pentapeptide ligand (1996) J. Biol. Chem, 271, pp. 8545-8548
Gibson, T. J., Murphy, R. M., Design of peptidyl compounds that affect -amyloid aggregation: Importance of surface tension and context (2005) Biochemestry, 44, pp. 8898-8907
Findeis, M. A., Lee, J. -D., Kelley, M., Wakefield, J. D., Zhang, M. -H., Chin, J., Kubasek, W., Molineaux, S. M., Characterization of cholyl-leu-val-phephe-ala-OH as an inhibitor of amyloid beta-peptide polymerization (2001) Amyloid, 8, pp. 231-241
Gordon, D. J., Tappe, R., Meredith, S. C., Design and characterization of a membrane permeable N-methyl amino acid containing peptide that inhibits A 1-40 fibrillogenesis (2002) J. Pept. Res, 60, pp. 37-55
Chacon, M. A., Barria, M. I., Soto, C., Inestrosa, N. C., -sheet breaker peptide prevents A -induced spatial memory impairments with partial reduction of amyloid deposits (2004) Mol. Psychiatry, 9, pp. 953-961
Kates, S. A., Sol, N. A., Johnson, C. R., Hudson, D., Barany, G., Albericio, F., A novel, convenient, three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides (1993) Tetrahedron Lett, 34, pp. 1549-1552
Zagorski, M. G., Yang, J., Shao, H., Ma, K., Zeng, H., Hong, A., Methodological and chemical factors affecting amyloi- amyloidogenicity (1999) Methods Enzymol, 309, pp. 189-204
Blackley, H. K., Sanders, G. H., Davies, M. C., Roberts, C. J., Tendler, S. J., Wilkinson, M. J., In-situ atomic force microscopy study of beta-amyloid fibrillization (2000) J. Mol. Biol, 298, pp. 833-840
Arimon, M., D ez-P erez, I., Kogan, M. J., Durany, N., Giralt, E., Sanz, F., Fern ndez-Busquets, X., Fine structure study ofA 1-42 fibrillogenesis with atomic forcemicroscopy (2005) FASEB J, 19, pp. 1344-1346
Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity
Aggregation of the amyloid Aβ peptide and its accumulation into insoluble deposits (plaques) are believed to be the main cause of neuronal dysfunction associated with Alzheimer's disease (AD); small molecules that can interfere with the Aβ amyloid fibril formation are therefore of interest for a potential therapeutic strategy. Three new trehalose-conjugated peptides of the well known β-sheet breaker peptide iAβ5p,were synthesized. The disaccharide was covalently attached to different sites of the LPFFD peptide chain, i.e. at the N-terminus, C-terminus or at the Asp side chain. CD spectroscopy in different solvents was used to assess changes in the peptide conformation of these compounds. The effects of these glycopeptides on the self-assembly and morphology of Aβ aggregates were investigated by ThT fluorescence assay and dynamic Scanning Force Microscopy, respectively. All the synthesized compounds were tested as inhibitors of Aβ toxicity toward pure cultures of rat cortical neurons. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.
Aggregation of the amyloid Aβ peptide and its accumulation into insoluble deposits (plaques) are believed to be the main cause of neuronal dysfunction associated with Alzheimer's disease (AD); small molecules that can interfere with the Aβ amyloid fibril formation are therefore of interest for a potential therapeutic strategy. Three new trehalose-conjugated peptides of the well known β-sheet breaker peptide iAβ5p,were synthesized. The disaccharide was covalently attached to different sites of the LPFFD peptide chain, i.e. at the N-terminus, C-terminus or at the Asp side chain. CD spectroscopy in different solvents was used to assess changes in the peptide conformation of these compounds. The effects of these glycopeptides on the self-assembly and morphology of Aβ aggregates were investigated by ThT fluorescence assay and dynamic Scanning Force Microscopy, respectively. All the synthesized compounds were tested as inhibitors of Aβ toxicity toward pure cultures of rat cortical neurons. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.
Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity
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Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity
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Villari V, Tosto R, Di Natale G, Sinopoli A, Tomasello M, Lazzaro S, Micali N, Pappalardo G
* A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity (430 views)
Chemistryselect (ISSN: 2365-6549), 2017 Oct; 2(28): 9122-9129.
Impact Factor: 1.505
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (806 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (838 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (457 views)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (367 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (579 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
View Export to BibTeX Export to EndNote
* A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity (430 views)
Chemistryselect (ISSN: 2365-6549), 2017 Oct; 2(28): 9122-9129.
Impact Factor: 1.505
View Export to BibTeX Export to EndNote
Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (806 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
View Export to BibTeX Export to EndNote
Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
View Export to BibTeX Export to EndNote
Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (838 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
View Export to BibTeX Export to EndNote
Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (457 views)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
View Export to BibTeX Export to EndNote
Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
View Export to BibTeX Export to EndNote
Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (367 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
View Export to BibTeX Export to EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (579 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
View Export to BibTeX Export to EndNote
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
View Export to BibTeX Export to EndNote
10 Records (10 excluding Abstracts).
Total impact factor: 33.554 (33.554 excluding Abstracts).
Total 5 year impact factor: 32.401 (32.401 excluding Abstracts).
Total impact factor: 33.554 (33.554 excluding Abstracts).
Total 5 year impact factor: 32.401 (32.401 excluding Abstracts).
698 views. Last view on Saturday 27 May 2023, 2:29:36
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