Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity(698 views) De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
Keywords: β-Sheet Breaker Peptides, Amyloid-β, Neuronal Cultures, Thioflavin T, Trehalose, Amyloid Beta Protein[1-42], Pentapeptide, Animal Cell, Animal Tissue, Article, Brain Nerve Cell, Controlled Study, Drug Conformation, Drug Design, Drug Mechanism, Drug Structure, Drug Synthesis, Embryo, Nerve Cell Culture, Nonhuman, Priority Journal, Protein Aggregation, Protein Assembly, Atomic Force Microscopy, Brain Cortex, Cell Survival, Chemistry, Cytology, Drug Effect, High Performance Liquid Chromatography, Mass Spectrometry, Rattus, Cerebral Cortex, High Pressure Liquid, ß-Sheet Breaker Peptides, Amyloid Beta Protein [1-42], Chemical Synthesis, Pharmacology,
Affiliations: *** IBB - CNR ***
University of Catania, Department of Chemical Sciences, 95125 Catania, Italy
National Research Council, Institute of Biostructures and Bioimaging, 95125 Catania, Italy
University of Palermo, Department of Physical Chemistry F. Accascina, 90133 Palermo, Italy
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Selkoe, D. J., The molecular pathology of Alzheimer's disease (1991) Neuron, 6, pp. 487-49
Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., Cotman, C. W., Neurodegeneration induced by -amyloid peptides in vitro: The role of peptide assembly state (1993) J. Neurosci, 13, pp. 1676-1687
Simmons, L. K., May, P. C., Tommaselli, K. J., Rydel, R. E., Fuson, K. S., Brigham, E. F., Wright, S., Brems, D. N., Secondary structure of amyloid peptide correlates with neurotoxic activity in vitro (1994) Mol. Pharmacol, 45, pp. 373-379
Standridge, J. B., Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease (2006) Curr. Alzheimer Res, 3, pp. 95-108
McLean, C. A., Chemy, R. A., Fraser, F. W., Fuller, S. J., Smith, M. J., Beyreuther, K., Bush, A. I., Masters, C. L., Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease (1999) Ann. Neurol, 46, pp. 860-866
Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., Sabatini, B. L., Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway (2007) J. Neurosci, 27, pp. 2866-2875
Sciarretta, K. L., Gordon, D. J., Meredith, S., Peptide-based inhibitors of amyloid assembly (2006) Methods Enzymol, 413, pp. 273-312
Tjernberg, L. O., Naslund, J., Lindqvist, F., Johansson, J., Karlstrom, A. R., Thyberg, J., Terenius, L., Nordstedt, C., Arrest of -amyloid fibril formation by a pentapeptide ligand (1996) J. Biol. Chem, 271, pp. 8545-8548
Gibson, T. J., Murphy, R. M., Design of peptidyl compounds that affect -amyloid aggregation: Importance of surface tension and context (2005) Biochemestry, 44, pp. 8898-8907
Findeis, M. A., Lee, J. -D., Kelley, M., Wakefield, J. D., Zhang, M. -H., Chin, J., Kubasek, W., Molineaux, S. M., Characterization of cholyl-leu-val-phephe-ala-OH as an inhibitor of amyloid beta-peptide polymerization (2001) Amyloid, 8, pp. 231-241
Gordon, D. J., Tappe, R., Meredith, S. C., Design and characterization of a membrane permeable N-methyl amino acid containing peptide that inhibits A 1-40 fibrillogenesis (2002) J. Pept. Res, 60, pp. 37-55
Chacon, M. A., Barria, M. I., Soto, C., Inestrosa, N. C., -sheet breaker peptide prevents A -induced spatial memory impairments with partial reduction of amyloid deposits (2004) Mol. Psychiatry, 9, pp. 953-961
Kates, S. A., Sol, N. A., Johnson, C. R., Hudson, D., Barany, G., Albericio, F., A novel, convenient, three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides (1993) Tetrahedron Lett, 34, pp. 1549-1552
Zagorski, M. G., Yang, J., Shao, H., Ma, K., Zeng, H., Hong, A., Methodological and chemical factors affecting amyloi- amyloidogenicity (1999) Methods Enzymol, 309, pp. 189-204
Blackley, H. K., Sanders, G. H., Davies, M. C., Roberts, C. J., Tendler, S. J., Wilkinson, M. J., In-situ atomic force microscopy study of beta-amyloid fibrillization (2000) J. Mol. Biol, 298, pp. 833-840
Arimon, M., D ez-P erez, I., Kogan, M. J., Durany, N., Giralt, E., Sanz, F., Fern ndez-Busquets, X., Fine structure study ofA 1-42 fibrillogenesis with atomic forcemicroscopy (2005) FASEB J, 19, pp. 1344-1346
Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity