Chemistry of lipid a: At the heart of innate immunity (2083 views) (PDF restricted 308 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 7; 21(2): 500-519.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.771, 5-year impact factor: 5.572
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84920160035&partnerID=40&md5=726e58d7631a677daa71b8a6e667a216
Keywords: Innate Immunity, Lipid A, Lipid A Analogues, Lipopolysaccharide, Tlr4 Md-2 Complex, Bacteria, Gram-Negative Bacteria, Innate Immune Systems, Isolation And Characterization, Toll-Like Receptors, Za Analogues, Lipid a, Lipid a Analogues, Ly96 Protein, Human, Protein Md 2, Toll Like Receptor 4, Analogs And Derivatives, Animal, Chemical Structure, Chemistry, Gram Negative Bacterium, Gram Negative Infection, Immunology, Microbiology, Gram-Negative Bacterial Infections, Lymphocyte Antigen 96, Models, Molecular,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, via Cinthia 4Napoli, Italy
Division of Structural Biochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Parkallee 4a/cBorstel, Germany
Centre of Microbial Host Interactions (CMHI), Department of Science, ITT- DublinDublin, Ireland
School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 30, Quai Ernest -AnsermetGeneva, Switzerland
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2Milano, Italy
Institute of Biostructures and Bioimaging, National Research Council, Via Mezzocannone 16Naples, Italy
National Institute of Chemistry, Hajdrihova 19Ljubljana, Slovenia
Leibniz Ctr Med \& Biosci
University of Bodenkultur Wien
Consiglio Nazionale delle Ricerche (CNR)
Consejo Superior de Investigaciones Cientificas (CSIC)
San Pablo CEU University
References:
Not available.
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 7; 21(2): 500-519.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.771, 5-year impact factor: 5.572
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84920160035&partnerID=40&md5=726e58d7631a677daa71b8a6e667a216
Keywords: Innate Immunity, Lipid A, Lipid A Analogues, Lipopolysaccharide, Tlr4 Md-2 Complex, Bacteria, Gram-Negative Bacteria, Innate Immune Systems, Isolation And Characterization, Toll-Like Receptors, Za Analogues, Lipid a, Lipid a Analogues, Ly96 Protein, Human, Protein Md 2, Toll Like Receptor 4, Analogs And Derivatives, Animal, Chemical Structure, Chemistry, Gram Negative Bacterium, Gram Negative Infection, Immunology, Microbiology, Gram-Negative Bacterial Infections, Lymphocyte Antigen 96, Models, Molecular,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, via Cinthia 4Napoli, Italy
Division of Structural Biochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Parkallee 4a/cBorstel, Germany
Centre of Microbial Host Interactions (CMHI), Department of Science, ITT- DublinDublin, Ireland
School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 30, Quai Ernest -AnsermetGeneva, Switzerland
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2Milano, Italy
Institute of Biostructures and Bioimaging, National Research Council, Via Mezzocannone 16Naples, Italy
National Institute of Chemistry, Hajdrihova 19Ljubljana, Slovenia
Leibniz Ctr Med \& Biosci
University of Bodenkultur Wien
Consiglio Nazionale delle Ricerche (CNR)
Consejo Superior de Investigaciones Cientificas (CSIC)
San Pablo CEU University
References:
Not available.
Chemistry of lipid a: At the heart of innate immunity
In many Gram-negative bacteria, lipopolysaccharide (LPS) and its lipid A moiety are pivotal for bacterial survival. Depending on its structure, lipid A carries the toxic properties of the LPS and acts as a potent elicitor of the host innate immune system via the Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD-2) receptor complex. It often causes a wide variety of biological effects ranging from a remarkable enhancement of the resistance to the infection to an uncontrolled and massive immune response resulting in sepsis and septic shock. Since the bioactivity of lipid A is strongly influenced by its primary structure, a broad range of chemical syntheses of lipid A derivatives have made an enormous contribution to the characterization of lipid A bioactivity, providing novel pharmacological targets for the development of new biomedical therapies. Here, we describe and discuss the chemical aspects regarding lipid A and its role in innate immunity, from the (bio)synthesis, isolation and characterization to the molecular recognition at the atomic level. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
In many Gram-negative bacteria, lipopolysaccharide (LPS) and its lipid A moiety are pivotal for bacterial survival. Depending on its structure, lipid A carries the toxic properties of the LPS and acts as a potent elicitor of the host innate immune system via the Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD-2) receptor complex. It often causes a wide variety of biological effects ranging from a remarkable enhancement of the resistance to the infection to an uncontrolled and massive immune response resulting in sepsis and septic shock. Since the bioactivity of lipid A is strongly influenced by its primary structure, a broad range of chemical syntheses of lipid A derivatives have made an enormous contribution to the characterization of lipid A bioactivity, providing novel pharmacological targets for the development of new biomedical therapies. Here, we describe and discuss the chemical aspects regarding lipid A and its role in innate immunity, from the (bio)synthesis, isolation and characterization to the molecular recognition at the atomic level. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Chemistry of lipid a: At the heart of innate immunity
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Chemistry of lipid a: At the heart of innate immunity
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View Export to BibTeX Export to EndNote
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Impact Factor: 3.009
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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* Defense Against Pathogens: Structural Insights into the Mechanism of Chitin Induced Activation of Innate Immunity (271 views)
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Impact Factor: 3.469
View Export to BibTeX Export to EndNote
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Cell Microbiol (ISSN: 1462-5814), 2017 May; 19(5): e12691-e12691.
Impact Factor: 4.41
View Export to BibTeX Export to EndNote
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Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Speciale I, Paciello I, Fazio LL, Sturiale L, Palmigiano A, Lanzetta R, Parrilli M, Garozzo D, Lemaitre B, Bernardini ML, Molinaro A, De Castro C
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Impact Factor: 1.817
View Export to BibTeX Export to EndNote
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Impact Factor: 4.258
View Export to BibTeX Export to EndNote
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* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (378 views)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
View Export to BibTeX Export to EndNote
Avitabile C, D'Andrea LD, Romanelli A
* Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells (593 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2014 Mar 12; 4: 4293-4293.
Impact Factor: 5.578
View Export to BibTeX Export to EndNote
Musumeci D, Roviello GN, Montesarchio D
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Impact Factor: 9.723
View Export to BibTeX Export to EndNote
Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
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Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S
* Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish (790 views)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2013 Nov; 57(11): 5665-5673.
Impact Factor: 4.451
View Export to BibTeX Export to EndNote
Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A
* Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria (510 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 0925-4439), 2013 Jun; 1830(6): 3767-3775.
Impact Factor: 3.829
View Export to BibTeX Export to EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (462 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
View Export to BibTeX Export to EndNote
Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (472 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (565 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (559 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (724 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
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Berisio R
* Editorial: cell processes in bacterial diseases (414 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
Impact Factor: 1.994
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De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (457 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
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Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (513 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (456 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (437 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Vitiello M, Galdiero S, D'Isanto M, D'Amico M, Di Filippo C, Cantisani M, Galdiero M, Pedone C
* Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin (401 views)
Microbes And Infection / Institut Pasteur (ISSN: 1286-4579), 2008 May; 10(6): 657-663.
Impact Factor: 2.801
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (454 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (682 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (725 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (482 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (606 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (784 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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33 Records (33 excluding Abstracts).
Total impact factor: 133.057 (133.057 excluding Abstracts).
Total 5 year impact factor: 140.817 (140.817 excluding Abstracts).
Total impact factor: 133.057 (133.057 excluding Abstracts).
Total 5 year impact factor: 140.817 (140.817 excluding Abstracts).
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