Chemistry of lipid a: At the heart of innate immunity (2733 views) (PDF restricted 378 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 7; 21(2): 500-519.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.771, 5-year impact factor: 5.572
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84920160035&partnerID=40&md5=726e58d7631a677daa71b8a6e667a216
Keywords: Innate Immunity, Lipid A, Lipid A Analogues, Lipopolysaccharide, Tlr4 Md-2 Complex, Bacteria, Gram-Negative Bacteria, Innate Immune Systems, Isolation And Characterization, Toll-Like Receptors, Za Analogues, Lipid a, Lipid a Analogues, Ly96 Protein, Human, Protein Md 2, Toll Like Receptor 4, Analogs And Derivatives, Animal, Chemical Structure, Chemistry, Gram Negative Bacterium, Gram Negative Infection, Immunology, Microbiology, Gram-Negative Bacterial Infections, Lymphocyte Antigen 96, Models, Molecular,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, via Cinthia 4Napoli, Italy
Division of Structural Biochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Parkallee 4a/cBorstel, Germany
Centre of Microbial Host Interactions (CMHI), Department of Science, ITT- DublinDublin, Ireland
School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 30, Quai Ernest -AnsermetGeneva, Switzerland
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2Milano, Italy
Institute of Biostructures and Bioimaging, National Research Council, Via Mezzocannone 16Naples, Italy
National Institute of Chemistry, Hajdrihova 19Ljubljana, Slovenia
Leibniz Ctr Med \& Biosci
University of Bodenkultur Wien
Consiglio Nazionale delle Ricerche (CNR)
Consejo Superior de Investigaciones Cientificas (CSIC)
San Pablo CEU University
References:
Not available.
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 7; 21(2): 500-519.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.771, 5-year impact factor: 5.572
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84920160035&partnerID=40&md5=726e58d7631a677daa71b8a6e667a216
Keywords: Innate Immunity, Lipid A, Lipid A Analogues, Lipopolysaccharide, Tlr4 Md-2 Complex, Bacteria, Gram-Negative Bacteria, Innate Immune Systems, Isolation And Characterization, Toll-Like Receptors, Za Analogues, Lipid a, Lipid a Analogues, Ly96 Protein, Human, Protein Md 2, Toll Like Receptor 4, Analogs And Derivatives, Animal, Chemical Structure, Chemistry, Gram Negative Bacterium, Gram Negative Infection, Immunology, Microbiology, Gram-Negative Bacterial Infections, Lymphocyte Antigen 96, Models, Molecular,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, via Cinthia 4Napoli, Italy
Division of Structural Biochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Parkallee 4a/cBorstel, Germany
Centre of Microbial Host Interactions (CMHI), Department of Science, ITT- DublinDublin, Ireland
School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 30, Quai Ernest -AnsermetGeneva, Switzerland
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2Milano, Italy
Institute of Biostructures and Bioimaging, National Research Council, Via Mezzocannone 16Naples, Italy
National Institute of Chemistry, Hajdrihova 19Ljubljana, Slovenia
Leibniz Ctr Med \& Biosci
University of Bodenkultur Wien
Consiglio Nazionale delle Ricerche (CNR)
Consejo Superior de Investigaciones Cientificas (CSIC)
San Pablo CEU University
References:
Not available.
Chemistry of lipid a: At the heart of innate immunity
In many Gram-negative bacteria, lipopolysaccharide (LPS) and its lipid A moiety are pivotal for bacterial survival. Depending on its structure, lipid A carries the toxic properties of the LPS and acts as a potent elicitor of the host innate immune system via the Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD-2) receptor complex. It often causes a wide variety of biological effects ranging from a remarkable enhancement of the resistance to the infection to an uncontrolled and massive immune response resulting in sepsis and septic shock. Since the bioactivity of lipid A is strongly influenced by its primary structure, a broad range of chemical syntheses of lipid A derivatives have made an enormous contribution to the characterization of lipid A bioactivity, providing novel pharmacological targets for the development of new biomedical therapies. Here, we describe and discuss the chemical aspects regarding lipid A and its role in innate immunity, from the (bio)synthesis, isolation and characterization to the molecular recognition at the atomic level. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
In many Gram-negative bacteria, lipopolysaccharide (LPS) and its lipid A moiety are pivotal for bacterial survival. Depending on its structure, lipid A carries the toxic properties of the LPS and acts as a potent elicitor of the host innate immune system via the Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD-2) receptor complex. It often causes a wide variety of biological effects ranging from a remarkable enhancement of the resistance to the infection to an uncontrolled and massive immune response resulting in sepsis and septic shock. Since the bioactivity of lipid A is strongly influenced by its primary structure, a broad range of chemical syntheses of lipid A derivatives have made an enormous contribution to the characterization of lipid A bioactivity, providing novel pharmacological targets for the development of new biomedical therapies. Here, we describe and discuss the chemical aspects regarding lipid A and its role in innate immunity, from the (bio)synthesis, isolation and characterization to the molecular recognition at the atomic level. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Chemistry of lipid a: At the heart of innate immunity
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Chemistry of lipid a: At the heart of innate immunity
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 4.451
View Export to BibTeX Export to EndNote
Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A
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Impact Factor: 3.829
View Export to BibTeX Export to EndNote
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Impact Factor: 2.551
View Export to BibTeX Export to EndNote
Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
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Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (782 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (1173 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (1106 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
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Berisio R
* Editorial: cell processes in bacterial diseases (699 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
Impact Factor: 1.994
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De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (912 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
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Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (845 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (673 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (683 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Vitiello M, Galdiero S, D'Isanto M, D'Amico M, Di Filippo C, Cantisani M, Galdiero M, Pedone C
* Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin (1040 views)
Microbes And Infection / Institut Pasteur (ISSN: 1286-4579), 2008 May; 10(6): 657-663.
Impact Factor: 2.801
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (848 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (1062 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (1097 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (739 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (1125 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (1149 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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33 Records (33 excluding Abstracts).
Total impact factor: 133.057 (133.057 excluding Abstracts).
Total 5 year impact factor: 140.817 (140.817 excluding Abstracts).
Total impact factor: 133.057 (133.057 excluding Abstracts).
Total 5 year impact factor: 140.817 (140.817 excluding Abstracts).
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