Giant cell tumor and Paget's disease of bone in one family: geographic clustering
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Giant cell tumor and Paget's disease of bone in one family: geographic clustering (462 views)

Rendina D, Mossetti G, Soscia E, Sirignano C, Insabato L, Viceconti R, Ignarra R, Salvatore M, Nunziata V

Clinical Orthopaedics And Related Research (ISSN: 0009-921x), 2004 Apr; (421): 218-224.

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Paper type: Journal Article,

Impact factor: 1.403, 5-year impact factor: 3.189

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-2342476513&partnerID=40&md5=c29a1705e97b375f44e32bc48c948c07

Keywords: Bisphosphonic Acid Derivative, Clodronic Acid, Cobalt 60, Dexamethasone, Pamidronic Acid, Salcatonin, Adult, Aged, Article, Benign Tumor, Bone Biopsy, Clinical Article, Computer Assisted Tomography, Environmental Factor, Family Study, Female, Genetic Linkage, Giant Cell Tumor, Human, Human Tissue, Italy, Paget Bone Disease, Pedigree Analysis, Priority Journal, Tumor Classification, Tumor Diagnosis, Bone Neoplasms, Giant Cell Tumor Of Bone, Middle Aged, Osteitis Deformans,

Affiliations:
*** IBB - CNR ***

Dept. of Clin. and Exp. Medicine, Federico II Univ. Medical School, Naples, Italy
Dept. of Biomorphol. and Funct. Sci., Dept. of Diagn. Imaging/Radiother., Federico II Univ. Medical School, Naples, Italy
National Research Council (CNR), Biostruct. and Bioimaging Institute, Federico II Univ. Medical School, Naples, Italy
Dept. of Funct. and Morphol. Sci., Section of Pathology, Federico II Univ. Medical School, Naples, Italy
Dipto. di Med. Clin. e Sperimentale, Universitá Federico II, via S. Pansini, 5, 80131, Naples, Italy


References:
Not available.
Giant cell tumor and Paget's disease of bone in one family: geographic clustering

Giant cell tumor is a rare complication of Paget's disease of bone. Typically, this tumor occurs in the case of polyostotic disease and only in pagetic bones. This tumor rarely has been seen in multiple family members who have Paget's disease, although Paget's bone disease clearly has a hereditary component. Our report documents four cases of polyostotic Paget's bone disease complicated by benign giant cell tumor. In two patients, the giant cell tumor also was multifocal. All patients were from one family. They were born in Avellino and reside in Campania, a Southern Italian region. The ancestors of the patients with familial giant cell tumor in Paget's bone disease were born in the same geographic area. These data suggest that a combination of environmental and genetic factors could be responsible for linkage of the patients born in Avellino with this neoplasm that is highly unusual in patients with Paget's disease of bone.
Giant cell tumor and Paget's disease of bone in one family: geographic clustering

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Giant cell tumor and Paget's disease of bone in one family: geographic clustering

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5 Records (4 excluding Abstracts).
Total impact factor: 16.166 (13.758 excluding Abstracts).
Total 5 year impact factor: 17.23 (14.772 excluding Abstracts).

Last modified by Marco Comerci on Sunday 12 July 2020, 13:15:10
462 views. Last view on Friday 06 December 2024, 7:51:53