A randomized controlled pilot trial of lithium in spinocerebellar ataxia type two(619 views) Saccà F, Puorro G, Brunetti A, Capasso G, Cervo A, Cocozza S, De Leva M, Marsili A, Pane C, Quarantelli M, Russo CV, Trepiccione F, De Michele G, Filla A, Morra VB
Keywords: Autophagy, Clinical Trial, Lithium, Sca2, Spinocerebellar Ataxia Type 2, Lithium Carbonate, Placebo, Adult, Article, Behavior Disorder, Bipolar Disorder, Brain Size, Clinical Article, Cognitive Defect, Constipation, Controlled Study, Depression Inventory, Disease Course, Double Blind Procedure, Drug Induced Headache, Essential Hypertension, Female, Follow Up, Human, Major Depression, Muscle Cramp, Nuclear Magnetic Resonance Imaging, Parenchyma, Paresthesia, Peripheral Edema, Polydipsia, Polyuria, Priority Journal, Quality Of Life, Randomized Controlled Trial, Sample Size, Spinocerebellar Degeneration, Tremor, Water Deprivation, Weakness, Enzyme Inhibitor, Atrophy, Drug Effects, Middle Aged, Pathology, Pathophysiology, Phase 2 Clinical Trial, Pilot Study, Severity Of Illness Index, Treatment Outcome, Double-Blind Method, Pilot Projects,
Affiliations: *** IBB - CNR ***
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Napoli, NA, Italy, francesco.sacca@unina.it.
Department of Advanced Biomedical Sciences, University Federico IINaples, Italy
Division of Nephrology, Department of Cardio-Thoracic and Respiratory Sciences, Second University of NaplesNaples, Italy
Biostructure and Bioimaging Institute, National Research CouncilNaples, Italy
Universita degli Studi di Napoli Federico II
Seconda Universita degli Studi di Napoli
Consiglio Nazionale delle Ricerche
References: Pulst, S.M., Nechiporuk, A., Nechiporuk, T., Moderate expansion of a normally biallelic trinucleotide repeat in spinoc-erebellar ataxia type 2 (1996) Nat Genet, 14, pp. 269-27
Huynh, D.P., Yang, H.T., Vakharia, H., Nguyen, D., Pulst, S.M., Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death (2003) Hum Mol Gen, 12, pp. 1485-1496
Satterfield, T.F., Pallanck, L.J., Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes (2006) Hum Mol Genet, 15, pp. 2523-2532
Huynh, D.P., Figueroa, K., Hoang, N., Pulst, S.M., Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human (2000) Nat Genet, 26, pp. 44-50
Liu, J., Tang, T.S., Tu, H., Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2 (2009) J Neuro-Sci, 29, pp. 9148-9162
Sarkar, S., Floto, R.A., Berger, Z., Lithium induces autophagy by inhibiting inositol monophosphatase (2005) J Cell Biol, 170, pp. 1101-1111
Sarkar, S., Rubinsztein, D.C., Inositol and IP3 levels regulate autophagy: Biology and therapeutic speculations (2006) Autophagy, 2, pp. 132-134
Hering, S., Achmuller, C., Kohler, A., Poewe, W., Schneider, R., Boesch, S.M., Phenotype variability in spinocerebellar ataxia type 2: A longitudinal family survey and a case featuring an unusual benign course of disease (2009) Mov Disord, 24, pp. 774-777
Scale for the assessment and rating of ataxia: Development of a new clinical scale (2006) Neurology, 13 (66), pp. 1717-1720. , Schmitz-Hu¨bsch T, du Montcel ST, Baliko Let al
Hurst, N.P., Kind, P., Ruta, D., Hunter, M., Stubbings, A., Measuring health-related quality of life in rheumatoid arthritis: Validity, responsiveness and reliability of EuroQol (EQ-5D) (1997) Br J Rheumatol, 36, pp. 551-559
Beck, A.T., Steer, R.A., Brown, G.K., (1996) BDI-II—beck Depression Inventory, , 2nd edn. The Psychological Corporation Harcourt Brace and Company, San Antonio
Smith, S.M., Zhang, Y., Jenkinson, M., Chen, J., Matthews, P.M., Federico, A., De Stefano, N., Accurate, robust and automated longitudinal and cross-sectional brain change analysis (2002) Neuro-Image, 17, pp. 479-489
Smith, S.M., Jenkinson, M., Woolrich, M.W., Advances in functional and structural MR image analysis and implementation as FSL (2004) Neuroimage, 23, pp. 208-219
Smith, S.M., Fast robust automated brain extraction (2002) Hum Brain Mapp, 17, pp. 143-155
Jenkinson, M., Smith, S.M., A global optimisation method for robust affine registration of brain images (2001) Med Image Anal, 5, pp. 143-156
Jenkinson, M., Bannister, P.R., Brady, J.M., Smith, S.M., Improved optimisation for the robust and accurate linear registration and motion correction of brain images (2002) Neuroimage, 17, pp. 825-841
Zhang, Y., Brady, M., Smith, S., Segmentation of brain MR images through a hidden Markov random field model and the expectation maximization algorithm (2001) IEEE Trans Med Imaging, 20, pp. 45-57
Bartsch, A.J., Bendszus, N., De Stefano, N., Homola, G., Smith, S., (2004) Extending SIENA for a multi-subject statistical analysis of sample-specific cerebral edge shifts: Substantiation of early brain regeneration through abstinence from alcoholism (2004) Tenth International Conference on Functional Mapping of the Human Brain
Smith, S.M., De Stefano, N., Jenkinson, M., Matthews, P.M., Normalised accurate measurement of longitudinal brain change (2001) J Comput Assist Tomogr, 25, pp. 466-475
Saccá, F., Marsili, A., Quarantelli, M., A randomized clinical trial of lithium in multiple system atrophy (2013) J Neurol, 260, pp. 458-461
Trepiccione, F., Christensen, B.M., Lithium-induced neph-rogenic diabetes insipidus: New clinical and experimental findings (2010) J Nephrol, 23, pp. S43-S48
Jacobi, H., Bauer, P., Giunti, P., The natural history of spinocerebellar ataxia type 1, 2, 3, and 6: A 2-year follow-up study (2011) Neurology, 77, pp. 1035-1041
Schmitz-Hubsch, T., Giunti, P., Stephenson, D.A., SCA functional index: A useful compound performance measure for spinocerebellar ataxia (2008) Neurology, 71, pp. 486-492
Phatak, P., Shaldivin, A., King, L.S., Shapiro, P., Regenold, W.T., Lithium and inositol: Effects on brain water homeostasis in the rat (2006) Psychopharmacology, 186, pp. 41-47
Mezer, A., Yeatman, J.D., Stikov, N., Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging (2013) Nat Med, 19, pp. 1667-1672
Hering, S., Achmüller, C., Köhler, A., Phenotype variability in spinocerebellar ataxia type 2: A longitudinal family survey and a case featuring an unusual benign course of disease (2009) Mov Disord, 24, pp. 774-777
Saute, J.A., De Castilhos, R.M., Monte, T.L., A randomized, phase 2 clinical trial of lithium carbonate in Machado-Joseph disease (2014) Mov Disord, 29, pp. 568-573
A randomized controlled pilot trial of lithium in spinocerebellar ataxia type two
Cusanno F, Cisbani E, Colilli S, Fratoni R, Garibaldi F, Giuliani F, Gricia M, Lucentini M, Magliozzi ML, Santarivenere F, Torrioli S, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, De Vincentis G, Scopinaro F * Results of clinical trials with SPEM(278 views) Nucl Instrum Methods Phys Res Sect A, 2007 Feb 1; 497(1): 46-50. Impact Factor:3.221 ViewExport to BibTeXExport to EndNote