Self-assembled or mixed peptide amphiphile micelles from herpes simplex virus glycoproteins as potential immunomodulatory treatment (491 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 May 7; 9(1): 2137-2148.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 4.383, 5-year impact factor: 4.742
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84900384692&partnerID=40&md5=f49ec43f6f86a8d0673db90c91d6bee8
Keywords: Epitopes, Hsv, Self-Adjuvant Vaccine, Glycoprotein B, Herpes Simplex Vaccine, Interleukin 23, Macrophage Inflammatory Protein 2, Tumor Necrosis Factor Alpha, Cytokine, Simplexvirus, Herpes Simplex Virus Type 1, Immunologic Factor, Micelle, Peptide, Surfactant, Virus Envelope Protein, Amino Terminal Sequence, Animal Cell, Article, Controlled Study, Cytokine Release, Drug Formulation, Drug Mixture, Human, Human Cell, Hydrophobicity, Immunomodulation, Micellization, Mouse, Nonhuman, Peptide Analysis, Solid, Vaccine Production, Zeta Potential, Chemistry, Drug Effects, Feasibility Study, Synthesis, U937 Cell Line, Feasibility Studies, Surface-Active Agents, Viral Envelope Proteins, Cytokines Immunology, Immunologic Factors Chemical Synthesis Pharmacology, Macrophages Drug Effects Immunology, Peptides Chemical Synthesis Pharmacology, Surface-Active Agents Chemical Synthesis Pharmacology, Viral Envelope Proteins Chemistry,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, Interuniversitary Centre for Research on Bioactive peptides, CIRPeB, University of Naples Federico II, Institute of Biostructures and Bioimaging IBB-CNR, Naples, Italy
Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Second University of Naples, Naples, Italy
Department of Clinical Pathology and Transfusion Medicine, University Hospital Ruggi d'Aragona, Salerno, Italy
References:
Accardo, A., Tesauro, D., Morelli, G., Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors (2013) Polym J, 45, pp. 481-49
Yu, M.K., Park, J., Jon, S., Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy (2012) Theranostics, 2 (1), pp. 3-44
Lammers, T., Aime, S., Hennink, W.E., Storm, G., Kiessling, F., Theranostic nanomedicine (2011) Acc Chem Res, 44 (10), pp. 1029-1038
Accardo, A., Salsano, G., Morisco, A., Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (2012) Intern J Nanomed, 7, pp. 2007-2017
Kieler-Ferguson, H.M., Fréchet, J.M., Szoka Jr., F.C., Clinical developments of chemotherapeutic nanomedicines: Polymers and liposomes for delivery of camptothecins and platinum (II) drugs (2013) Wiley Interdiscip Rev Nanomed Nanobiotechnol, 5 (2), pp. 130-138
Black, M., Trent, A., Kostenko, Y., Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo (2012) Adv Mater, 24 (28), pp. 3845-3849
Moyle, P.M., Toth, I., Self-adjuvanting lipopeptide vaccines (2008) Curr Med Chem, 15 (5), pp. 506-516
Eriksson, E.M., Jackson, D.C., Recent advances with TLR2-targeting lipopeptide-based vaccines (2007) Curr Protein Pept Sci, 8 (4), pp. 412-417
Galdiero, S., Vitiello, M., Finamore, E., Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (2012) Mol BioSyst, 8 (12), pp. 3166-3177
Lee, K.C., Carlson, P.A., Goldstein, A.S., Yager, P., Gelb, M.H., Protection of a decapeptide from proteolytic cleavage by lipidation and self-assembly into high-axial ratio microstructures: A kinetic and structural study (1999) Langmuir, 15 (17), pp. 5500-5508
Missirlis, D., Khant, H., Tirrell, M., Mechanism of peptide amphiphile internalization by SJSA-1 cells in vitro (2009) Biochemistry, 48 (15), pp. 3304-3314
Aymard, M., Current epidemiology of herpes (2002) Pathol Biol (Paris, 50 (7), pp. 425-435. , French
Whitley, R.J., Kimberlin, D.W., Roizman, B., Herpes simplex viruses (1998) Clin Infect Dis, 26 (3), pp. 541-553
Kodukula, P., Liu, T., Rooijen, N.V., Jager, M.J., Hendricks, R.L., Macrophage control of herpes simplex virus type 1 replication in the peripheral nervous system (1999) J Immunol, 162 (5), pp. 2895-2905
Cantin, E.M., Hinton, D.R., Chen, J., Openshaw, H., Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1 (1995) J Virol, 69 (8), pp. 4898-4905
Koelle, D.M., Vaccines for herpes simplex virus infections (2006) Curr Opin Investig Drugs, 7 (2), pp. 136-141
Whitley, R., Herpes simplex viruses Field's Virology, p. 2006. , Knipe DM, Howley PM, Griffen DE, et al, 3rd ed. Philadelphia: Lippincott-Raven Publishers
Liu, K., Jiang, D., Zhang, L., Identification of B- and T-cell epitopes from glycoprotein B of herpes simplex virus 2 and evaluation of their immunogenicity and protection efficacy (2012) Vaccine, 30 (19), pp. 3034-3041
Kim, M., Taylor, J., Sidney, J., Immunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjects (2008) J Immunol, 181 (9), pp. 3615-6604
Lankford, C.S., Frucht, D.M., A unique role for IL-23 in promoting cellular immunity (2003) J Leukoc Biol, 73 (1), pp. 49-56
Schmitt, L., Dietrich, C., Tampe, R., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J Am Chem Soc, 116 (19), pp. 8485-8491
Chan, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis: A Practical Approach, , Oxford: Oxford University Press
Accardo, A., Mansi, R., Morisco, A., Peptide modified nanocarriers for selective targeting of bombesin receptors (2010) Mol Biosys, 6 (5), pp. 878-887
Morisco, A., Accardo, A., Gianolio, E., Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (2009) J Pept Sci, 15 (3), pp. 242-250
Birdi, K.S., Singh, H.N., Dalsager, S.U., Interaction of ionic micelles with the hydrophobic fluorescent-probe 1-anilino-8-naphthalenesulfonate (1979) J Phys Chem, 83 (21), pp. 2733-2737
de Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., A fluorimetric method for the estimation of the critical micelle concentration of surfactants (1981) Anal Biochem, 115 (2), pp. 278-286
Galdiero, M., Tortora, A., Damiano, N., Vitiello, M., Longanella, A., Galdiero, E., Induction of cytokine mRNA expression in U937 cells by Salmonella typhimurium porins is regulated by different phosphorylation pathways (2005) Med Microbiol Immunol, 194 (1-2), pp. 13-23
Taylor, M.F., Paulauskis, J.D., Weller, D.D., Kobzik, L., In vitro efficacy of morpholino-modified antisense oligomers directed against tumor necrosis factor-alpha mRNA (1996) J Biol Chem, 271 (29), pp. 17445-17452
Yin, E.T., Galanos, C., Kinsky, S., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from gram-negative bacteria (1972) Biochim Biophys Acta, 261 (1), pp. 284-289
Mosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays (1983) J Immunol Methods, 65 (1-2), pp. 55-63
Hudecz, F., Hilbert, A., Mezö, G., Epitope mapping of the 273-284 region of HSV glycoprotein D by synthetic branched polypeptide carrier conjugates (1993) Pept Res, 6 (5), pp. 263-271
Bettahi, I., Nesburn, A.B., Yoon, S., Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines (2007) Invest Ophthalmol Vis Sci, 48 (10), pp. 4643-4653
Nesburn, A.B., Ramos, T.V., Zhu, X., Asgarzadeh, H., Nguyen, V., Benmohamed, L., Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant (2005) Vaccine, 23 (7), pp. 873-883
Stanberry, L.R., Spruance, S.L., Cunningham, A.L., GlaxoSmithKline Herpes Vaccine Efficacy Study Group. Glycoprotein D adjuvant vaccine to prevent gential herpes (2002) N Engl J Med, 347 (21), pp. 1652-1661
Koelle, D.M., Corey, L., Recent progress in herpes simplex virus immunobiology and vaccine research (2003) Clin Microbiol Rev, 16 (1), pp. 96-113
Wallace, M.E., Keating, R., Heath, W.R., Carbone, F.R., The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant (1999) J Virol, 73 (9), pp. 7619-7623
Behanna, H.A., Donners, J.J., Gordon, A.C., Stupp, S.I., Coassembly of amphiphiles with opposite peptide polarities into nanofibers (2005) J Am Chem Soc, 127 (4), pp. 1193-1200
Romagnani, S., Th1/Th2 cells (1999) Inflamm Bowel Dis, 5 (4), pp. 285-294
Oppmann, B., Lesley, R., Blom, B., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 (2000) Immunity, 13 (5), pp. 715-725
Pirhonen, J., Matikainen, S., Julkunen, I., Regulation of virus-induced IL-12 and IL-23 expression in human macrophages (2002) J Immunol, 169 (10), pp. 5673-5678
Boniface, K., Blom, B., Liu, Y.J., de Waal, M.R., From interleukin-23 to T-helper 17 cells: Human T-helper cell differentiation revisited (2008) Immunol Rev, 226, pp. 132-146
Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M., Stockinger, B., TGFß in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells (2006) Immunity, 24 (2), pp. 179-189
Yu, M. K., Park, J., Jon, S., Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy (2012) Theranostics, 2 (1), pp. 3-44
Moyle, P. M., Toth, I., Self-adjuvanting lipopeptide vaccines (2008) Curr Med Chem, 15 (5), pp. 506-516
Eriksson, E. M., Jackson, D. C., Recent advances with TLR2-targeting lipopeptide-based vaccines (2007) Curr Protein Pept Sci, 8 (4), pp. 412-417
Lee, K. C., Carlson, P. A., Goldstein, A. S., Yager, P., Gelb, M. H., Protection of a decapeptide from proteolytic cleavage by lipidation and self-assembly into high-axial ratio microstructures: A kinetic and structural study (1999) Langmuir, 15 (17), pp. 5500-5508
Whitley, R. J., Kimberlin, D. W., Roizman, B., Herpes simplex viruses (1998) Clin Infect Dis, 26 (3), pp. 541-553
Cantin, E. M., Hinton, D. R., Chen, J., Openshaw, H., Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1 (1995) J Virol, 69 (8), pp. 4898-4905
Koelle, D. M., Vaccines for herpes simplex virus infections (2006) Curr Opin Investig Drugs, 7 (2), pp. 136-141
Lankford, C. S., Frucht, D. M., A unique role for IL-23 in promoting cellular immunity (2003) J Leukoc Biol, 73 (1), pp. 49-56
Chan, W. C., White, P. D., (2000) Fmoc Solid Phase Peptide Synthesis: A Practical Approach, , Oxford: Oxford University Press
Birdi, K. S., Singh, H. N., Dalsager, S. U., Interaction of ionic micelles with the hydrophobic fluorescent-probe 1-anilino-8-naphthalenesulfonate (1979) J Phys Chem, 83 (21), pp. 2733-2737
Taylor, M. F., Paulauskis, J. D., Weller, D. D., Kobzik, L., In vitro efficacy of morpholino-modified antisense oligomers directed against tumor necrosis factor-alpha mRNA (1996) J Biol Chem, 271 (29), pp. 17445-17452
Yin, E. T., Galanos, C., Kinsky, S., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from gram-negative bacteria (1972) Biochim Biophys Acta, 261 (1), pp. 284-289
Nesburn, A. B., Ramos, T. V., Zhu, X., Asgarzadeh, H., Nguyen, V., Benmohamed, L., Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant (2005) Vaccine, 23 (7), pp. 873-883
Stanberry, L. R., Spruance, S. L., Cunningham, A. L., GlaxoSmithKline Herpes Vaccine Efficacy Study Group. Glycoprotein D adjuvant vaccine to prevent gential herpes (2002) N Engl J Med, 347 (21), pp. 1652-1661
Koelle, D. M., Corey, L., Recent progress in herpes simplex virus immunobiology and vaccine research (2003) Clin Microbiol Rev, 16 (1), pp. 96-113
Wallace, M. E., Keating, R., Heath, W. R., Carbone, F. R., The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant (1999) J Virol, 73 (9), pp. 7619-7623
Behanna, H. A., Donners, J. J., Gordon, A. C., Stupp, S. I., Coassembly of amphiphiles with opposite peptide polarities into nanofibers (2005) J Am Chem Soc, 127 (4), pp. 1193-1200
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 May 7; 9(1): 2137-2148.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 4.383, 5-year impact factor: 4.742
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84900384692&partnerID=40&md5=f49ec43f6f86a8d0673db90c91d6bee8
Keywords: Epitopes, Hsv, Self-Adjuvant Vaccine, Glycoprotein B, Herpes Simplex Vaccine, Interleukin 23, Macrophage Inflammatory Protein 2, Tumor Necrosis Factor Alpha, Cytokine, Simplexvirus, Herpes Simplex Virus Type 1, Immunologic Factor, Micelle, Peptide, Surfactant, Virus Envelope Protein, Amino Terminal Sequence, Animal Cell, Article, Controlled Study, Cytokine Release, Drug Formulation, Drug Mixture, Human, Human Cell, Hydrophobicity, Immunomodulation, Micellization, Mouse, Nonhuman, Peptide Analysis, Solid, Vaccine Production, Zeta Potential, Chemistry, Drug Effects, Feasibility Study, Synthesis, U937 Cell Line, Feasibility Studies, Surface-Active Agents, Viral Envelope Proteins, Cytokines Immunology, Immunologic Factors Chemical Synthesis Pharmacology, Macrophages Drug Effects Immunology, Peptides Chemical Synthesis Pharmacology, Surface-Active Agents Chemical Synthesis Pharmacology, Viral Envelope Proteins Chemistry,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, Interuniversitary Centre for Research on Bioactive peptides, CIRPeB, University of Naples Federico II, Institute of Biostructures and Bioimaging IBB-CNR, Naples, Italy
Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Second University of Naples, Naples, Italy
Department of Clinical Pathology and Transfusion Medicine, University Hospital Ruggi d'Aragona, Salerno, Italy
References:
Accardo, A., Tesauro, D., Morelli, G., Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors (2013) Polym J, 45, pp. 481-49
Yu, M.K., Park, J., Jon, S., Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy (2012) Theranostics, 2 (1), pp. 3-44
Lammers, T., Aime, S., Hennink, W.E., Storm, G., Kiessling, F., Theranostic nanomedicine (2011) Acc Chem Res, 44 (10), pp. 1029-1038
Accardo, A., Salsano, G., Morisco, A., Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (2012) Intern J Nanomed, 7, pp. 2007-2017
Kieler-Ferguson, H.M., Fréchet, J.M., Szoka Jr., F.C., Clinical developments of chemotherapeutic nanomedicines: Polymers and liposomes for delivery of camptothecins and platinum (II) drugs (2013) Wiley Interdiscip Rev Nanomed Nanobiotechnol, 5 (2), pp. 130-138
Black, M., Trent, A., Kostenko, Y., Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo (2012) Adv Mater, 24 (28), pp. 3845-3849
Moyle, P.M., Toth, I., Self-adjuvanting lipopeptide vaccines (2008) Curr Med Chem, 15 (5), pp. 506-516
Eriksson, E.M., Jackson, D.C., Recent advances with TLR2-targeting lipopeptide-based vaccines (2007) Curr Protein Pept Sci, 8 (4), pp. 412-417
Galdiero, S., Vitiello, M., Finamore, E., Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (2012) Mol BioSyst, 8 (12), pp. 3166-3177
Lee, K.C., Carlson, P.A., Goldstein, A.S., Yager, P., Gelb, M.H., Protection of a decapeptide from proteolytic cleavage by lipidation and self-assembly into high-axial ratio microstructures: A kinetic and structural study (1999) Langmuir, 15 (17), pp. 5500-5508
Missirlis, D., Khant, H., Tirrell, M., Mechanism of peptide amphiphile internalization by SJSA-1 cells in vitro (2009) Biochemistry, 48 (15), pp. 3304-3314
Aymard, M., Current epidemiology of herpes (2002) Pathol Biol (Paris, 50 (7), pp. 425-435. , French
Whitley, R.J., Kimberlin, D.W., Roizman, B., Herpes simplex viruses (1998) Clin Infect Dis, 26 (3), pp. 541-553
Kodukula, P., Liu, T., Rooijen, N.V., Jager, M.J., Hendricks, R.L., Macrophage control of herpes simplex virus type 1 replication in the peripheral nervous system (1999) J Immunol, 162 (5), pp. 2895-2905
Cantin, E.M., Hinton, D.R., Chen, J., Openshaw, H., Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1 (1995) J Virol, 69 (8), pp. 4898-4905
Koelle, D.M., Vaccines for herpes simplex virus infections (2006) Curr Opin Investig Drugs, 7 (2), pp. 136-141
Whitley, R., Herpes simplex viruses Field's Virology, p. 2006. , Knipe DM, Howley PM, Griffen DE, et al, 3rd ed. Philadelphia: Lippincott-Raven Publishers
Liu, K., Jiang, D., Zhang, L., Identification of B- and T-cell epitopes from glycoprotein B of herpes simplex virus 2 and evaluation of their immunogenicity and protection efficacy (2012) Vaccine, 30 (19), pp. 3034-3041
Kim, M., Taylor, J., Sidney, J., Immunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjects (2008) J Immunol, 181 (9), pp. 3615-6604
Lankford, C.S., Frucht, D.M., A unique role for IL-23 in promoting cellular immunity (2003) J Leukoc Biol, 73 (1), pp. 49-56
Schmitt, L., Dietrich, C., Tampe, R., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J Am Chem Soc, 116 (19), pp. 8485-8491
Chan, W.C., White, P.D., (2000) Fmoc Solid Phase Peptide Synthesis: A Practical Approach, , Oxford: Oxford University Press
Accardo, A., Mansi, R., Morisco, A., Peptide modified nanocarriers for selective targeting of bombesin receptors (2010) Mol Biosys, 6 (5), pp. 878-887
Morisco, A., Accardo, A., Gianolio, E., Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (2009) J Pept Sci, 15 (3), pp. 242-250
Birdi, K.S., Singh, H.N., Dalsager, S.U., Interaction of ionic micelles with the hydrophobic fluorescent-probe 1-anilino-8-naphthalenesulfonate (1979) J Phys Chem, 83 (21), pp. 2733-2737
de Vendittis, E., Palumbo, G., Parlato, G., Bocchini, V., A fluorimetric method for the estimation of the critical micelle concentration of surfactants (1981) Anal Biochem, 115 (2), pp. 278-286
Galdiero, M., Tortora, A., Damiano, N., Vitiello, M., Longanella, A., Galdiero, E., Induction of cytokine mRNA expression in U937 cells by Salmonella typhimurium porins is regulated by different phosphorylation pathways (2005) Med Microbiol Immunol, 194 (1-2), pp. 13-23
Taylor, M.F., Paulauskis, J.D., Weller, D.D., Kobzik, L., In vitro efficacy of morpholino-modified antisense oligomers directed against tumor necrosis factor-alpha mRNA (1996) J Biol Chem, 271 (29), pp. 17445-17452
Yin, E.T., Galanos, C., Kinsky, S., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from gram-negative bacteria (1972) Biochim Biophys Acta, 261 (1), pp. 284-289
Mosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays (1983) J Immunol Methods, 65 (1-2), pp. 55-63
Hudecz, F., Hilbert, A., Mezö, G., Epitope mapping of the 273-284 region of HSV glycoprotein D by synthetic branched polypeptide carrier conjugates (1993) Pept Res, 6 (5), pp. 263-271
Bettahi, I., Nesburn, A.B., Yoon, S., Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines (2007) Invest Ophthalmol Vis Sci, 48 (10), pp. 4643-4653
Nesburn, A.B., Ramos, T.V., Zhu, X., Asgarzadeh, H., Nguyen, V., Benmohamed, L., Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant (2005) Vaccine, 23 (7), pp. 873-883
Stanberry, L.R., Spruance, S.L., Cunningham, A.L., GlaxoSmithKline Herpes Vaccine Efficacy Study Group. Glycoprotein D adjuvant vaccine to prevent gential herpes (2002) N Engl J Med, 347 (21), pp. 1652-1661
Koelle, D.M., Corey, L., Recent progress in herpes simplex virus immunobiology and vaccine research (2003) Clin Microbiol Rev, 16 (1), pp. 96-113
Wallace, M.E., Keating, R., Heath, W.R., Carbone, F.R., The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant (1999) J Virol, 73 (9), pp. 7619-7623
Behanna, H.A., Donners, J.J., Gordon, A.C., Stupp, S.I., Coassembly of amphiphiles with opposite peptide polarities into nanofibers (2005) J Am Chem Soc, 127 (4), pp. 1193-1200
Romagnani, S., Th1/Th2 cells (1999) Inflamm Bowel Dis, 5 (4), pp. 285-294
Oppmann, B., Lesley, R., Blom, B., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 (2000) Immunity, 13 (5), pp. 715-725
Pirhonen, J., Matikainen, S., Julkunen, I., Regulation of virus-induced IL-12 and IL-23 expression in human macrophages (2002) J Immunol, 169 (10), pp. 5673-5678
Boniface, K., Blom, B., Liu, Y.J., de Waal, M.R., From interleukin-23 to T-helper 17 cells: Human T-helper cell differentiation revisited (2008) Immunol Rev, 226, pp. 132-146
Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M., Stockinger, B., TGFß in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells (2006) Immunity, 24 (2), pp. 179-189
Yu, M. K., Park, J., Jon, S., Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy (2012) Theranostics, 2 (1), pp. 3-44
Moyle, P. M., Toth, I., Self-adjuvanting lipopeptide vaccines (2008) Curr Med Chem, 15 (5), pp. 506-516
Eriksson, E. M., Jackson, D. C., Recent advances with TLR2-targeting lipopeptide-based vaccines (2007) Curr Protein Pept Sci, 8 (4), pp. 412-417
Lee, K. C., Carlson, P. A., Goldstein, A. S., Yager, P., Gelb, M. H., Protection of a decapeptide from proteolytic cleavage by lipidation and self-assembly into high-axial ratio microstructures: A kinetic and structural study (1999) Langmuir, 15 (17), pp. 5500-5508
Whitley, R. J., Kimberlin, D. W., Roizman, B., Herpes simplex viruses (1998) Clin Infect Dis, 26 (3), pp. 541-553
Cantin, E. M., Hinton, D. R., Chen, J., Openshaw, H., Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1 (1995) J Virol, 69 (8), pp. 4898-4905
Koelle, D. M., Vaccines for herpes simplex virus infections (2006) Curr Opin Investig Drugs, 7 (2), pp. 136-141
Lankford, C. S., Frucht, D. M., A unique role for IL-23 in promoting cellular immunity (2003) J Leukoc Biol, 73 (1), pp. 49-56
Chan, W. C., White, P. D., (2000) Fmoc Solid Phase Peptide Synthesis: A Practical Approach, , Oxford: Oxford University Press
Birdi, K. S., Singh, H. N., Dalsager, S. U., Interaction of ionic micelles with the hydrophobic fluorescent-probe 1-anilino-8-naphthalenesulfonate (1979) J Phys Chem, 83 (21), pp. 2733-2737
Taylor, M. F., Paulauskis, J. D., Weller, D. D., Kobzik, L., In vitro efficacy of morpholino-modified antisense oligomers directed against tumor necrosis factor-alpha mRNA (1996) J Biol Chem, 271 (29), pp. 17445-17452
Yin, E. T., Galanos, C., Kinsky, S., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from gram-negative bacteria (1972) Biochim Biophys Acta, 261 (1), pp. 284-289
Nesburn, A. B., Ramos, T. V., Zhu, X., Asgarzadeh, H., Nguyen, V., Benmohamed, L., Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant (2005) Vaccine, 23 (7), pp. 873-883
Stanberry, L. R., Spruance, S. L., Cunningham, A. L., GlaxoSmithKline Herpes Vaccine Efficacy Study Group. Glycoprotein D adjuvant vaccine to prevent gential herpes (2002) N Engl J Med, 347 (21), pp. 1652-1661
Koelle, D. M., Corey, L., Recent progress in herpes simplex virus immunobiology and vaccine research (2003) Clin Microbiol Rev, 16 (1), pp. 96-113
Wallace, M. E., Keating, R., Heath, W. R., Carbone, F. R., The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant (1999) J Virol, 73 (9), pp. 7619-7623
Behanna, H. A., Donners, J. J., Gordon, A. C., Stupp, S. I., Coassembly of amphiphiles with opposite peptide polarities into nanofibers (2005) J Am Chem Soc, 127 (4), pp. 1193-1200
Self-assembled or mixed peptide amphiphile micelles from herpes simplex virus glycoproteins as potential immunomodulatory treatment
The use of micelle aggregates formed from peptide amphiphiles (PAs) as potential synthetic self-adjuvant vaccines to treat Herpes simplex virus (HSV) infection are reported here. The PAs were based on epitopes gB409-505 and gD301-309, selected from HSV envelope glycoprotein B (gB) and glycoprotein D (gD), that had their N-terminus modified with hydrophobic moieties containing two C18 hydrocarbon chains. Pure and mixed micelles of gB and/or gD peptide epitopes were easily prepared after starting with the synthesis of corresponding PAs by solid phase methods. Structural characterization of the aggregates confirmed that they were sufficiently stable and compatible with in vivo use: critical micelle concentration values around 4.0 · 10-7 mol · Kg-1; hydrodynamic radii (RH) between 50-80 nm, and a zeta potential (?) around -40 mV were found for all aggregates. The in vitro results indicate that both peptide epitopes and micelles, at 10 µM, triggered U937 and RAW 264.7 cells to release appreciable levels of cytokines. In particular, interleukin (IL)-23-, IL-6-, IL-8- or macrophage inflammatory protein (MIP)-2-, and tumor necrosis factor (TNF)-a-release increased considerably when cells were treated with the gB-micelles or gD-micelles compared with the production of the same cytokines when the stimulus was the single gB or gD peptide. © 2014 Accardo et al.
The use of micelle aggregates formed from peptide amphiphiles (PAs) as potential synthetic self-adjuvant vaccines to treat Herpes simplex virus (HSV) infection are reported here. The PAs were based on epitopes gB409-505 and gD301-309, selected from HSV envelope glycoprotein B (gB) and glycoprotein D (gD), that had their N-terminus modified with hydrophobic moieties containing two C18 hydrocarbon chains. Pure and mixed micelles of gB and/or gD peptide epitopes were easily prepared after starting with the synthesis of corresponding PAs by solid phase methods. Structural characterization of the aggregates confirmed that they were sufficiently stable and compatible with in vivo use: critical micelle concentration values around 4.0 · 10-7 mol · Kg-1; hydrodynamic radii (RH) between 50-80 nm, and a zeta potential (?) around -40 mV were found for all aggregates. The in vitro results indicate that both peptide epitopes and micelles, at 10 µM, triggered U937 and RAW 264.7 cells to release appreciable levels of cytokines. In particular, interleukin (IL)-23-, IL-6-, IL-8- or macrophage inflammatory protein (MIP)-2-, and tumor necrosis factor (TNF)-a-release increased considerably when cells were treated with the gB-micelles or gD-micelles compared with the production of the same cytokines when the stimulus was the single gB or gD peptide. © 2014 Accardo et al.
Self-assembled or mixed peptide amphiphile micelles from herpes simplex virus glycoproteins as potential immunomodulatory treatment
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Self-assembled or mixed peptide amphiphile micelles from herpes simplex virus glycoproteins as potential immunomodulatory treatment
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Falanga A, Tarallo R, Vitiello G, Vitiello M, Perillo E, Cantisani M, D'Errico G, Galdiero M, Galdiero S
* Biophysical Characterization and Membrane Interaction of the Two Fusion Loops of Glycoprotein B from Herpes Simplex Type I Virus (526 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Feb 23; 7(2): N/D-N/D.
Impact Factor: 3.73
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Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
* Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (433 views)
Molecular Biosystems (ISSN: 1742-206x), 2012; 8(12): 3166-3177.
Impact Factor: 3.35
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Vitiello G, Falanga A, Galdiero M, Marsh D, Galdiero S, D'Errico G
* Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes (687 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Oct; 1808(10): 2517-2526.
Impact Factor: 3.99
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Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
* The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2008 Mar 25; 9(5): 758-767.
Impact Factor: 3.322
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Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
* Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (619 views)
Journal Of General Virology (ISSN: 0022-1317), 2006 May; 87: 1085-1097.
Impact Factor: 3.11
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Galdiero S, Falanga A, Vitiello M, Browne H, Pedone C, Galdiero M
* Fusogenic domains in herpes simplex virus type 1 glycoprotein (593 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Sep 5; 280(31): 28632-28643.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
* Biophysical Characterization and Membrane Interaction of the Two Fusion Loops of Glycoprotein B from Herpes Simplex Type I Virus (526 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Feb 23; 7(2): N/D-N/D.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
* Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (433 views)
Molecular Biosystems (ISSN: 1742-206x), 2012; 8(12): 3166-3177.
Impact Factor: 3.35
View Export to BibTeX Export to EndNote
Vitiello G, Falanga A, Galdiero M, Marsh D, Galdiero S, D'Errico G
* Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes (687 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Oct; 1808(10): 2517-2526.
Impact Factor: 3.99
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
* The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2008 Mar 25; 9(5): 758-767.
Impact Factor: 3.322
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
* Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (619 views)
Journal Of General Virology (ISSN: 0022-1317), 2006 May; 87: 1085-1097.
Impact Factor: 3.11
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, Browne H, Pedone C, Galdiero M
* Fusogenic domains in herpes simplex virus type 1 glycoprotein (593 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Sep 5; 280(31): 28632-28643.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
6 Records (5 excluding Abstracts).
Total impact factor: 23.356 (19.626 excluding Abstracts).
Total 5 year impact factor: 23.978 (19.734 excluding Abstracts).
Total impact factor: 23.356 (19.626 excluding Abstracts).
Total 5 year impact factor: 23.978 (19.734 excluding Abstracts).
491 views. Last view on Tuesday 09 May 2023, 8:08:18
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