G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection (577 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2014 Jun; 1840(6): 2050-2059.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.353, 5-year impact factor: 5.132
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84897504907&partnerID=40&md5=4d883fd2f9a84e312a2c41e96b4641f9
Keywords: Disordered Protein Region, Helical Stability, Surface Plasmon Resonance, Guanine Quadruplex, Myc Protein, Nucleophosmin, Article, Binding Affinity, Carboxy Terminal Sequence, Complex Formation, Controlled Study, Dna Binding, Priority Journal, Protein Motif, Protein Unfolding, Thermostability, Triple Helix, Circular Dichroism, Dna Helix, Molecular Recognition, Protein Determination, Protein Dissection, Protein Folding, Protein Protein Interaction, Protein Structure, Function And Variability, Structure Analysis, Amino Acid Sequence, G-Quadruplexes, Humans, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Nuclear Proteins, Proto-Oncogene Proteins C-Myc, Nuclear Proteins Chemistry Physiology, Proto-Oncogene Proteins C-Myc Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Naples Federico II, DFM-Scarl, 80134 Naples, Italy
CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples Federico II, DFM-Scarl, 80134 Naples, Italy
Center for Advanced Biomaterials for Healthcare CRIB, Istituto Italiano di Tecnologia (IIT), 80125 Naples, Italy
Institute of Biostructures and Bioimaging, CNR, 80134 Naples, Italy
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
References:
Kang, Y.J., Olson, M.O., Jones, C., Busch, H., Nucleolar phosphoproteins of normal rat liver and Novikoff hepatoma ascites cells (1975) Cancer Res., 35, pp. 1470-147
Okuwaki, M., Matsumoto, K., Tsujimoto, M., Nagata, K., Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone (2001) FEBS Lett., 506, pp. 272-276
Borer, R.A., Lehner, C.F., Eppenberger, H.M., Nigg, E.A., Major nucleolar proteins shuttle between nucleus and cytoplasm (1989) Cell, 56, pp. 379-390
Okuwaki, M., Iwamatsu, A., Tsujimoto, M., Nagata, K., Identification of nucleophosmin/B23, an acidic nucleolar protein, as a stimulatory factor for in vitro replication of adenovirus DNA complexed with viral basic core proteins (2001) J. Mol. Biol., 311, pp. 41-55
Lindstrom, M.S., NPM1/B23: A multifunctional chaperone in ribosome biogenesis and chromatin remodeling (2011) Biochem. Res. Int., p. 195209. , (16 pp.)
Maggi, Jr.L.B., Kuchenruether, M., Dadey, D.Y., Schwope, R.M., Grisendi, S., Townsend, R.R., Pandolfi, P.P., Weber, J.D., Nucleophosmin serves as a rate-limiting nuclear export chaperone for the mammalian ribosome (2008) Mol. Cell. Biol., 28, pp. 7050-7065
Colombo, E., Alcalay, M., Pelicci, P.G., Nucleophosmin and its complex network: A possible therapeutic target in hematological diseases (2011) Oncogene, 30, pp. 2595-2609
Yun, J.P., Miao, J., Chen, G.G., Tian, Q.H., Zhang, C.Q., Xiang, J., Fu, J., Lai, P.B., Increased expression of nucleophosmin/B23 in hepatocellular carcinoma and correlation with clinicopathological parameters (2007) Br. J. Cancer, 96, pp. 477-484
Grisendi, S., Mecucci, C., Falini, B., Pandolfi, P.P., Nucleophosmin and cancer (2006) Nat. Rev. Cancer, 6, pp. 493-505
Balusu, R., Fiskus, W., Rao, R., Chong, D.G., Nalluri, S., Mudunuru, U., Ma, H., Bhalla, K.N., Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1 (2011) Blood, 118, pp. 3096-3106
Falini, B., Nicoletti, I., Bolli, N., Martelli, M.P., Liso, A., Gorello, P., Mandelli, F., Martelli, M.F., Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias (2007) Haematologica, 92, pp. 519-532
Falini, B., Mecucci, C., Tiacci, E., Alcalay, M., Rosati, R., Pasqualucci, L., La Starza, R., Martelli, M.F., Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype (2005) N. Engl. J. Med., 352, pp. 254-266
Falini, B., Bolli, N., Shan, J., Martelli, M.P., Liso, A., Pucciarini, A., Bigerna, B., Nicoletti, I., Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc + AML (2006) Blood, 107, pp. 4514-4523
Okuwaki, M., Sumi, A., Hisaoka, M., Saotome-Nakamura, A., Akashi, S., Nishimura, Y., Nagata, K., Function of homo- and hetero-oligomers of human nucleoplasmin/ nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling (2012) Nucleic Acids Res., 40, pp. 4861-4878
Okuwaki, M., The structure and functions of NPM1/nucleophosmin/B23, a multifunctional nucleolar acidic protein (2008) J. Biochem., 143, pp. 441-448
Namboodiri, V.M., Akey, I.V., Schmidt-Zachmann, M.S., Head, J.F., Akey, C.W., The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus (2004) Structure, 12, pp. 2149-2160
Lee, H.H., Kim, H.S., Kang, J.Y., Lee, B.I., Ha, J.Y., Yoon, H.J., Lim, S.O., Suh, S.W., Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface (2007) Proteins, 69, pp. 672-678
Grummitt, C.G., Townsley, F.M., Johnson, C.M., Warren, A.J., Bycroft, M., Structural consequences of nucleophosmin mutations in acute myeloid leukemia (2008) J. Biol. Chem., 283, pp. 23326-23332
Federici, L., Falini, B., Nucleophosmin mutations in acute myeloid leukemia: A tale of protein unfolding and mislocalization (2013) Protein Sci., 22, pp. 545-556
Marasco, D., Ruggiero, A., Vascotto, C., Poletto, M., Scognamiglio, P.L., Tell, G., Vitagliano, L., Role of mutual interactions in the chemical and thermal stability of nucleophosmin NPM1 domains (2013) Biochem. Biophys. Res. Commun., 430, pp. 523-528
Scaloni, F., Federici, L., Brunori, M., Gianni, S., Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain (2010) Proc. Natl. Acad. Sci. U. S. A., 107, pp. 5447-5452
Scaloni, F., Gianni, S., Federici, L., Falini, B., Brunori, M., Folding mechanism of the C-terminal domain of nucleophosmin: Residual structure in the denatured state and its pathophysiological significance (2009) FASEB J., 23, pp. 2360-2365
Chiarella, S., Federici, L., Di Matteo, A., Brunori, M., Gianni, S., The folding pathway of a functionally competent C-terminal domain of nucleophosmin: Protein stability and denatured state residual structure (2013) Biochem. Biophys. Res. Commun., 435, pp. 64-68
Fantini, D., Vascotto, C., Marasco, D., D'Ambrosio, C., Romanello, M., Vitagliano, L., Pedone, C., Tell, G., Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions (2010) Nucleic Acids Res., 38, pp. 8239-8256
Hisaoka, M., Ueshima, S., Murano, K., Nagata, K., Okuwaki, M., Regulation of nucleolar chromatin by B23/nucleophosmin jointly depends upon its RNA binding activity and transcription factor UBF (2010) Mol. Cell. Biol., 30, pp. 4952-4964
Colombo, E., Marine, J.C., Danovi, D., Falini, B., Pelicci, P.G., Nucleophosmin regulates the stability and transcriptional activity of p53 (2002) Nat. Cell Biol., 4, pp. 529-533
Lee, C., Smith, B.A., Bandyopadhyay, K., Gjerset, R.A., DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF (2005) Cancer Res., 65, pp. 9834-9842
Jian, Y., Gao, Z., Sun, J., Shen, Q., Feng, F., Jing, Y., Yang, C., RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells (2009) Oncogene, 28, pp. 4201-4211
Gadad, S.S., Rajan, R.E., Senapati, P., Chatterjee, S., Shandilya, J., Dash, P.K., Ranga, U., Kundu, T.K., HIV-1 infection induces acetylation of NPM1 that facilitates Tat localization and enhances viral transactivation (2011) J. Mol. Biol., 410, pp. 997-1007
Wang, D., Baumann, A., Szebeni, A., Olson, M.O., The nucleic acid binding activity of nucleolar protein B23.1 resides in its carboxyl-terminal end (1994) J. Biol. Chem., 269, pp. 30994-30998
Dumbar, T.S., Gentry, G.A., Olson, M.O., Interaction of nucleolar phosphoprotein B23 with nucleic acids (1989) Biochemistry, 28, pp. 9495-9501
Federici, L., Arcovito, A., Scaglione, G.L., Scaloni, F., Lo Sterzo, C., Di Matteo, A., Falini, B., Brunori, M., Nucleophosmin C-terminal leukemia-associated domain interacts with G-rich quadruplex forming DNA (2010) J. Biol. Chem., 285, pp. 37138-37149
Gallo, A., Lo Sterzo, C., Mori, M., Di Matteo, A., Bertini, I., Banci, L., Brunori, M., Federici, L., Structure of nucleophosmin DNA-binding domain and analysis of its complex with a G-quadruplex sequence from the c-MYC promoter (2012) J. Biol. Chem., 287, pp. 26539-26548
Burge, S., Parkinson, G.N., Hazel, P., Todd, A.K., Neidle, S., Quadruplex DNA: Sequence, topology and structure (2006) Nucleic Acids Res., 34, pp. 5402-5415
Siddiqui-Jain, A., Grand, C.L., Bearss, D.J., Hurley, L.H., Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription (2002) Proc. Natl. Acad. Sci. U. S. A., 99, pp. 11593-11598
Vascotto, C., Fantini, D., Romanello, M., Cesaratto, L., Deganuto, M., Leonardi, A., Radicella, J.P., Tell, G., APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process (2009) Mol. Cell. Biol., 29, pp. 1834-1854
Poletto, M., Vascotto, C., Scognamiglio, P.L., Lirussi, L., Marasco, D., Tell, G., Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) (2013) Biochem. J., 452, pp. 545-557
Rich, R.L., Myszka, D.G., Advances in surface Plasmon resonance biosensor analysis (2000) Curr. Opin. Biotechnol., 11, pp. 54-61
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Griesinger, C., Otting, G., Wuthrich, K., Ernst, R.R., Clean TOCSY for H-1 spin system-identification in macromolecules (1988) J. Am. Chem. Soc., 110, pp. 7870-7872
Kumar, A., Ernst, R.R., Wuthrich, K., A two-dimensional nuclear overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules (1980) Biochem. Biophys. Res. Commun., 95, pp. 1-6
Dalvit, C., Efficient multiple-solvent suppression for the study of the interactions of organic solvents with biomolecules (1998) J. Biomol. NMR, 11, pp. 437-444
Bartels, C., Xia, T.H., Billeter, M., Guntert, P., Wuthrich, K., The program XEASY for computer-supported NMR spectral analysis of biological macromolecules (1995) J. Biomol. NMR, 6, pp. 1-10
Johnson, B.A., Using NMRView to visualize and analyze the NMR spectra of macromolecules (2004) Methods Mol. Biol., 278, pp. 313-352
Schwarzinger, S., Kroon, G.J., Foss, T.R., Wright, P.E., Dyson, H.J., Random coil chemical shifts in acidic 8 M urea: Implementation of random coil shift data in NMRView (2000) J. Biomol. NMR, 18, pp. 43-48
Wishart, D.S., Bigam, C.G., Holm, A., Hodges, R.S., Sykes, B.D., 1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects (1995) J. Biomol. NMR, 5, pp. 67-81
Herrmann, T., Guntert, P., Wuthrich, K., Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA (2002) J. Mol. Biol., 319, pp. 209-227
Koradi, R., Billeter, M., Wuthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graph., 14, pp. 51-55. , (29-32)
Wüthrich, K., (1986) NMR of Proteins and Nucleic Acids, , John Wiley & Sons New York
Shepherd, N.E., Hoang, H.N., Abbenante, G., Fairlie, D.P., Single turn peptide alpha helices with exceptional stability in water (2005) J. Am. Chem. Soc., 127, pp. 2974-2983
Chiarella, S., De Cola, A., Scaglione, G.L., Carletti, E., Graziano, V., Barcaroli, D., Lo Sterzo, C., Federici, L., Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA (2013) Nucleic Acids Res., 41, pp. 3228-3239
Hisaoka, M., Nagata, K., Okuwaki, M., Intrinsically disordered regions of nucleophosmin/B23 regulate its RNA binding activity through their inter- and intra-molecular association (2014) Nucleic Acids Res., 17, pp. 1180-1195
Banuelos, S., Lectez, B., Taneva, S.G., Ormaza, G., Alonso-Marino, M., Calle, X., Urbaneja, M.A., Recognition of intermolecular G-quadruplexes by full length nucleophosmin. Effect of a leukaemia-associated mutation (2013) FEBS Lett., 587, pp. 2254-2259
Diana, D., Ziaco, B., Colombo, G., Scarabelli, G., Romanelli, A., Pedone, C., Fattorusso, R., D'Andrea, L.D., Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (2008) Chemistry, 14, pp. 4164-4166
Sanchez, I.E., Kiefhaber, T., Hammond behavior versus ground state effects in protein folding: Evidence for narrow free energy barriers and residual structure in unfolded states (2003) J. Mol. Biol., 327, pp. 867-884
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2014 Jun; 1840(6): 2050-2059.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.353, 5-year impact factor: 5.132
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84897504907&partnerID=40&md5=4d883fd2f9a84e312a2c41e96b4641f9
Keywords: Disordered Protein Region, Helical Stability, Surface Plasmon Resonance, Guanine Quadruplex, Myc Protein, Nucleophosmin, Article, Binding Affinity, Carboxy Terminal Sequence, Complex Formation, Controlled Study, Dna Binding, Priority Journal, Protein Motif, Protein Unfolding, Thermostability, Triple Helix, Circular Dichroism, Dna Helix, Molecular Recognition, Protein Determination, Protein Dissection, Protein Folding, Protein Protein Interaction, Protein Structure, Function And Variability, Structure Analysis, Amino Acid Sequence, G-Quadruplexes, Humans, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Nuclear Proteins, Proto-Oncogene Proteins C-Myc, Nuclear Proteins Chemistry Physiology, Proto-Oncogene Proteins C-Myc Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Naples Federico II, DFM-Scarl, 80134 Naples, Italy
CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples Federico II, DFM-Scarl, 80134 Naples, Italy
Center for Advanced Biomaterials for Healthcare CRIB, Istituto Italiano di Tecnologia (IIT), 80125 Naples, Italy
Institute of Biostructures and Bioimaging, CNR, 80134 Naples, Italy
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
References:
Kang, Y.J., Olson, M.O., Jones, C., Busch, H., Nucleolar phosphoproteins of normal rat liver and Novikoff hepatoma ascites cells (1975) Cancer Res., 35, pp. 1470-147
Okuwaki, M., Matsumoto, K., Tsujimoto, M., Nagata, K., Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone (2001) FEBS Lett., 506, pp. 272-276
Borer, R.A., Lehner, C.F., Eppenberger, H.M., Nigg, E.A., Major nucleolar proteins shuttle between nucleus and cytoplasm (1989) Cell, 56, pp. 379-390
Okuwaki, M., Iwamatsu, A., Tsujimoto, M., Nagata, K., Identification of nucleophosmin/B23, an acidic nucleolar protein, as a stimulatory factor for in vitro replication of adenovirus DNA complexed with viral basic core proteins (2001) J. Mol. Biol., 311, pp. 41-55
Lindstrom, M.S., NPM1/B23: A multifunctional chaperone in ribosome biogenesis and chromatin remodeling (2011) Biochem. Res. Int., p. 195209. , (16 pp.)
Maggi, Jr.L.B., Kuchenruether, M., Dadey, D.Y., Schwope, R.M., Grisendi, S., Townsend, R.R., Pandolfi, P.P., Weber, J.D., Nucleophosmin serves as a rate-limiting nuclear export chaperone for the mammalian ribosome (2008) Mol. Cell. Biol., 28, pp. 7050-7065
Colombo, E., Alcalay, M., Pelicci, P.G., Nucleophosmin and its complex network: A possible therapeutic target in hematological diseases (2011) Oncogene, 30, pp. 2595-2609
Yun, J.P., Miao, J., Chen, G.G., Tian, Q.H., Zhang, C.Q., Xiang, J., Fu, J., Lai, P.B., Increased expression of nucleophosmin/B23 in hepatocellular carcinoma and correlation with clinicopathological parameters (2007) Br. J. Cancer, 96, pp. 477-484
Grisendi, S., Mecucci, C., Falini, B., Pandolfi, P.P., Nucleophosmin and cancer (2006) Nat. Rev. Cancer, 6, pp. 493-505
Balusu, R., Fiskus, W., Rao, R., Chong, D.G., Nalluri, S., Mudunuru, U., Ma, H., Bhalla, K.N., Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1 (2011) Blood, 118, pp. 3096-3106
Falini, B., Nicoletti, I., Bolli, N., Martelli, M.P., Liso, A., Gorello, P., Mandelli, F., Martelli, M.F., Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias (2007) Haematologica, 92, pp. 519-532
Falini, B., Mecucci, C., Tiacci, E., Alcalay, M., Rosati, R., Pasqualucci, L., La Starza, R., Martelli, M.F., Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype (2005) N. Engl. J. Med., 352, pp. 254-266
Falini, B., Bolli, N., Shan, J., Martelli, M.P., Liso, A., Pucciarini, A., Bigerna, B., Nicoletti, I., Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc + AML (2006) Blood, 107, pp. 4514-4523
Okuwaki, M., Sumi, A., Hisaoka, M., Saotome-Nakamura, A., Akashi, S., Nishimura, Y., Nagata, K., Function of homo- and hetero-oligomers of human nucleoplasmin/ nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling (2012) Nucleic Acids Res., 40, pp. 4861-4878
Okuwaki, M., The structure and functions of NPM1/nucleophosmin/B23, a multifunctional nucleolar acidic protein (2008) J. Biochem., 143, pp. 441-448
Namboodiri, V.M., Akey, I.V., Schmidt-Zachmann, M.S., Head, J.F., Akey, C.W., The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus (2004) Structure, 12, pp. 2149-2160
Lee, H.H., Kim, H.S., Kang, J.Y., Lee, B.I., Ha, J.Y., Yoon, H.J., Lim, S.O., Suh, S.W., Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface (2007) Proteins, 69, pp. 672-678
Grummitt, C.G., Townsley, F.M., Johnson, C.M., Warren, A.J., Bycroft, M., Structural consequences of nucleophosmin mutations in acute myeloid leukemia (2008) J. Biol. Chem., 283, pp. 23326-23332
Federici, L., Falini, B., Nucleophosmin mutations in acute myeloid leukemia: A tale of protein unfolding and mislocalization (2013) Protein Sci., 22, pp. 545-556
Marasco, D., Ruggiero, A., Vascotto, C., Poletto, M., Scognamiglio, P.L., Tell, G., Vitagliano, L., Role of mutual interactions in the chemical and thermal stability of nucleophosmin NPM1 domains (2013) Biochem. Biophys. Res. Commun., 430, pp. 523-528
Scaloni, F., Federici, L., Brunori, M., Gianni, S., Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain (2010) Proc. Natl. Acad. Sci. U. S. A., 107, pp. 5447-5452
Scaloni, F., Gianni, S., Federici, L., Falini, B., Brunori, M., Folding mechanism of the C-terminal domain of nucleophosmin: Residual structure in the denatured state and its pathophysiological significance (2009) FASEB J., 23, pp. 2360-2365
Chiarella, S., Federici, L., Di Matteo, A., Brunori, M., Gianni, S., The folding pathway of a functionally competent C-terminal domain of nucleophosmin: Protein stability and denatured state residual structure (2013) Biochem. Biophys. Res. Commun., 435, pp. 64-68
Fantini, D., Vascotto, C., Marasco, D., D'Ambrosio, C., Romanello, M., Vitagliano, L., Pedone, C., Tell, G., Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions (2010) Nucleic Acids Res., 38, pp. 8239-8256
Hisaoka, M., Ueshima, S., Murano, K., Nagata, K., Okuwaki, M., Regulation of nucleolar chromatin by B23/nucleophosmin jointly depends upon its RNA binding activity and transcription factor UBF (2010) Mol. Cell. Biol., 30, pp. 4952-4964
Colombo, E., Marine, J.C., Danovi, D., Falini, B., Pelicci, P.G., Nucleophosmin regulates the stability and transcriptional activity of p53 (2002) Nat. Cell Biol., 4, pp. 529-533
Lee, C., Smith, B.A., Bandyopadhyay, K., Gjerset, R.A., DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF (2005) Cancer Res., 65, pp. 9834-9842
Jian, Y., Gao, Z., Sun, J., Shen, Q., Feng, F., Jing, Y., Yang, C., RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells (2009) Oncogene, 28, pp. 4201-4211
Gadad, S.S., Rajan, R.E., Senapati, P., Chatterjee, S., Shandilya, J., Dash, P.K., Ranga, U., Kundu, T.K., HIV-1 infection induces acetylation of NPM1 that facilitates Tat localization and enhances viral transactivation (2011) J. Mol. Biol., 410, pp. 997-1007
Wang, D., Baumann, A., Szebeni, A., Olson, M.O., The nucleic acid binding activity of nucleolar protein B23.1 resides in its carboxyl-terminal end (1994) J. Biol. Chem., 269, pp. 30994-30998
Dumbar, T.S., Gentry, G.A., Olson, M.O., Interaction of nucleolar phosphoprotein B23 with nucleic acids (1989) Biochemistry, 28, pp. 9495-9501
Federici, L., Arcovito, A., Scaglione, G.L., Scaloni, F., Lo Sterzo, C., Di Matteo, A., Falini, B., Brunori, M., Nucleophosmin C-terminal leukemia-associated domain interacts with G-rich quadruplex forming DNA (2010) J. Biol. Chem., 285, pp. 37138-37149
Gallo, A., Lo Sterzo, C., Mori, M., Di Matteo, A., Bertini, I., Banci, L., Brunori, M., Federici, L., Structure of nucleophosmin DNA-binding domain and analysis of its complex with a G-quadruplex sequence from the c-MYC promoter (2012) J. Biol. Chem., 287, pp. 26539-26548
Burge, S., Parkinson, G.N., Hazel, P., Todd, A.K., Neidle, S., Quadruplex DNA: Sequence, topology and structure (2006) Nucleic Acids Res., 34, pp. 5402-5415
Siddiqui-Jain, A., Grand, C.L., Bearss, D.J., Hurley, L.H., Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription (2002) Proc. Natl. Acad. Sci. U. S. A., 99, pp. 11593-11598
Vascotto, C., Fantini, D., Romanello, M., Cesaratto, L., Deganuto, M., Leonardi, A., Radicella, J.P., Tell, G., APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process (2009) Mol. Cell. Biol., 29, pp. 1834-1854
Poletto, M., Vascotto, C., Scognamiglio, P.L., Lirussi, L., Marasco, D., Tell, G., Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) (2013) Biochem. J., 452, pp. 545-557
Rich, R.L., Myszka, D.G., Advances in surface Plasmon resonance biosensor analysis (2000) Curr. Opin. Biotechnol., 11, pp. 54-61
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Griesinger, C., Otting, G., Wuthrich, K., Ernst, R.R., Clean TOCSY for H-1 spin system-identification in macromolecules (1988) J. Am. Chem. Soc., 110, pp. 7870-7872
Kumar, A., Ernst, R.R., Wuthrich, K., A two-dimensional nuclear overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules (1980) Biochem. Biophys. Res. Commun., 95, pp. 1-6
Dalvit, C., Efficient multiple-solvent suppression for the study of the interactions of organic solvents with biomolecules (1998) J. Biomol. NMR, 11, pp. 437-444
Bartels, C., Xia, T.H., Billeter, M., Guntert, P., Wuthrich, K., The program XEASY for computer-supported NMR spectral analysis of biological macromolecules (1995) J. Biomol. NMR, 6, pp. 1-10
Johnson, B.A., Using NMRView to visualize and analyze the NMR spectra of macromolecules (2004) Methods Mol. Biol., 278, pp. 313-352
Schwarzinger, S., Kroon, G.J., Foss, T.R., Wright, P.E., Dyson, H.J., Random coil chemical shifts in acidic 8 M urea: Implementation of random coil shift data in NMRView (2000) J. Biomol. NMR, 18, pp. 43-48
Wishart, D.S., Bigam, C.G., Holm, A., Hodges, R.S., Sykes, B.D., 1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects (1995) J. Biomol. NMR, 5, pp. 67-81
Herrmann, T., Guntert, P., Wuthrich, K., Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA (2002) J. Mol. Biol., 319, pp. 209-227
Koradi, R., Billeter, M., Wuthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graph., 14, pp. 51-55. , (29-32)
Wüthrich, K., (1986) NMR of Proteins and Nucleic Acids, , John Wiley & Sons New York
Shepherd, N.E., Hoang, H.N., Abbenante, G., Fairlie, D.P., Single turn peptide alpha helices with exceptional stability in water (2005) J. Am. Chem. Soc., 127, pp. 2974-2983
Chiarella, S., De Cola, A., Scaglione, G.L., Carletti, E., Graziano, V., Barcaroli, D., Lo Sterzo, C., Federici, L., Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA (2013) Nucleic Acids Res., 41, pp. 3228-3239
Hisaoka, M., Nagata, K., Okuwaki, M., Intrinsically disordered regions of nucleophosmin/B23 regulate its RNA binding activity through their inter- and intra-molecular association (2014) Nucleic Acids Res., 17, pp. 1180-1195
Banuelos, S., Lectez, B., Taneva, S.G., Ormaza, G., Alonso-Marino, M., Calle, X., Urbaneja, M.A., Recognition of intermolecular G-quadruplexes by full length nucleophosmin. Effect of a leukaemia-associated mutation (2013) FEBS Lett., 587, pp. 2254-2259
Diana, D., Ziaco, B., Colombo, G., Scarabelli, G., Romanelli, A., Pedone, C., Fattorusso, R., D'Andrea, L.D., Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (2008) Chemistry, 14, pp. 4164-4166
Sanchez, I.E., Kiefhaber, T., Hammond behavior versus ground state effects in protein folding: Evidence for narrow free energy barriers and residual structure in unfolded states (2003) J. Mol. Biol., 327, pp. 867-884
G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection
Background: Nucleophosmin (NPM1, B23) is a multifunctional protein that is involved in a variety of fundamental biological processes. NPM1/B23 deregulation is implicated in the pathogenesis of several human malignancies. This protein exerts its functions through the interaction with a multiplicity of biological partners. Very recently it is has been shown that NPM1/B23 specifically recognizes DNA G-quadruplexes through its C-terminal region. Methods: Through a rational dissection approach of protein here we show that the intrinsically unfolded regions of NPM1/B23 significantly contribute to the binding of c-MYC G-quadruplex motif. Interestingly, the analysis of the ability of distinct NPM1/B23 fragments to bind this quadruplex led to the identifications of distinct NPM1/ B23-based peptides that individually present a high affinity for this motif. Results: These results suggest that the tight binding of NPM1/B23 to the G-quadruplex is achieved through the cooperation of both folded and unfolded regions that are individually able to bind it. The dissection of NPM1/ B23 also unveils that its H1 helix is intrinsically endowed with an unusual thermal stability. Conclusions: These findings have implications for the unfolding mechanism of NPM1/B23, for the G-quadruplex affinity of the different NPM1/B23 isoforms and for the design of peptide-based molecules able to interact with this DNA motif. General observation: This study sheds new light in the molecular mechanism of the complex NPM1/G-quadruplex involved in acute myeloid leukemia (AML) disease. (c) 2014 Elsevier B.V. All rights reserved.
Background: Nucleophosmin (NPM1, B23) is a multifunctional protein that is involved in a variety of fundamental biological processes. NPM1/B23 deregulation is implicated in the pathogenesis of several human malignancies. This protein exerts its functions through the interaction with a multiplicity of biological partners. Very recently it is has been shown that NPM1/B23 specifically recognizes DNA G-quadruplexes through its C-terminal region. Methods: Through a rational dissection approach of protein here we show that the intrinsically unfolded regions of NPM1/B23 significantly contribute to the binding of c-MYC G-quadruplex motif. Interestingly, the analysis of the ability of distinct NPM1/B23 fragments to bind this quadruplex led to the identifications of distinct NPM1/ B23-based peptides that individually present a high affinity for this motif. Results: These results suggest that the tight binding of NPM1/B23 to the G-quadruplex is achieved through the cooperation of both folded and unfolded regions that are individually able to bind it. The dissection of NPM1/ B23 also unveils that its H1 helix is intrinsically endowed with an unusual thermal stability. Conclusions: These findings have implications for the unfolding mechanism of NPM1/B23, for the G-quadruplex affinity of the different NPM1/B23 isoforms and for the design of peptide-based molecules able to interact with this DNA motif. General observation: This study sheds new light in the molecular mechanism of the complex NPM1/G-quadruplex involved in acute myeloid leukemia (AML) disease. (c) 2014 Elsevier B.V. All rights reserved.
G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection
| ▼ Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors |
| ▼ Biomolecules able to modulate the VEGF-dependent angiogenesis |
G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
Scognamiglio PL, Doti N, Grieco P, Pedone C, Ruvo M, Marasco D
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View Export to BibTeX Export to EndNote
Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
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View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
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View Export to BibTeX Export to EndNote
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Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
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D'Agata R, Breveglieri G, Zanoli L, Borgatti M, Spoto G, Gambari R
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
Grasso G, Bush AI, D'Agata R, Rizzarelli E, Spoto G
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Eur Biophys J (ISSN: 1432-1017, 0175-7571, 0175-7571linking), 2009 Apr; 38(4): 407-414.
Impact Factor: 2.437
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (460 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (437 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (412 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Grasso G, Rizzarelli E, Spoto G
* How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin (354 views)
Bba-Gen Subjects (ISSN: 0006-3002, 1570-9639, 0925-4439), 2008 Jul; 1784(7-8): 1122-1126.
Impact Factor: 2.233
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (446 views)
Protein Expr Purif (ISSN: 1046-5928), 2008 Jun; 59(2): 302-308.
Impact Factor: 1.621
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Rossi M, Ruvo M, Marasco D, Colombo M, Cassani G, Verdoliva A
* Anti-allergic properties of a new all-D synthetic immunoglobulin-binding peptide (431 views)
Mol Immunol (ISSN: 0161-5890), 2008 Jan; 45(1): 226-234.
Impact Factor: 3.555
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Zanoli L, Dagata R, Spoto G
* Surface plasmon-based optical detection of DNA peptide nucleic acids (262 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 165-174.
Impact Factor: 0.1
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (359 views)
Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
Impact Factor: 3.664
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases (433 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.
Impact Factor: 2.945
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D'Agata R, Grasso G, Iacono G, Spoto G, Vecchio G
* Lectin recognition of a new SOD mimic bioconjugate studied with surface plasmon resonance imaging (303 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Feb 21; 4(4): 610-612.
Impact Factor: 2.874
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Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (577 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
Impact Factor: 3.574
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Arena G, Contino A, D'Agata R, Sgarlata C, Spoto G
* Ordered anchored cavities at work: A new and rapid SPR-based method for the detection of trace amounts of Cs+ (421 views)
New J Chem (ISSN: 1144-0546), 2005; 29(11): 1393-1395.
Impact Factor: 2.574
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* The Structural Duality of Nucleobases in Guanine Quadruplexes Controls Their Low-Energy Photoionization (12 views)
J Phys Chem Lett (ISSN: 1948-7185linking, 1948-7185electronic), 2021 Sep 2; 12(34): 8309-8313.
Impact Factor: 6.475
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Green JA, Asha H, Santoro F, Improta R
* Excitonic Model for Strongly Coupled Multichromophoric Systems: The Electronic Circular Dichroism Spectra of Guanine Quadruplexes as Test Cases (82 views)
J Chem Theory Comput (ISSN: 1549-9618linking, 1549-9626electronic), 2021 Jan 12; 17(1): 405-415.
Impact Factor: 5.39
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De Rosa L, Diana D, Di Stasi R, Romanelli A, Sciacca MF, Milardi D, Isernia C, Fattorusso R, D'Andrea LD
* Probing the helical stability in a VEGF-mimetic peptide (25 views)
Bioorganic Chemistry, 2021; 16: N/D-N/D.
Impact Factor: 5.307
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De Luca S, Verdoliva V, Saviano M, Fattorusso R, Diana D
* SPR and NMR characterization of the molecular interaction between A9 peptide and a model system of HER2 receptor: A fragment approach for selecting peptide structures specific for their target (135 views)
J Pept Sci (ISSN: 1075-2617linking, 1099-1387electronic), 2020 Feb; 26(2): e3231-e3231.
Impact Factor: 1.877
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Banyasz A, Balanikas E, Martinez-fernandez L, Baldacchino G, Douki T, Improta R, Markovitsi D
* Radicals Generated in Tetramolecular Guanine Quadruplexes by Photoionization: Spectral and Dynamical Features (89 views)
J Phys Chem B (ISSN: 1520-5207linking, 1520-6106), 2019 Jun 13; 123(23): 4950-4957.
Impact Factor: 3.603
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Martinez-fernandez L, Banyasz A, Markovitsi D, Improta R
* Topology Controls the Electronic Absorption and Delocalization of Electron Holes in Guanine Quadruplexes (427 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Oct 12; 24(57): 15185-15189.
Impact Factor: 5.476
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Deiana M, Mettra B, Martinez-fernandez L, Mazur LM, Pawlik K, Andraud C, Samoc M, Improta R, Monnereau C, Matczyszyn K
* Specific Recognition of G-Quadruplexes Over Duplex-DNA by a Macromolecular NIR Two-Photon Fluorescent Probe (429 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2017 Dec 7; 8(23): 5915-5920.
Impact Factor: 8.709
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La Manna S, Scognamiglio PL, Di Natale C, Leone M, Mercurio FA, Malfitano AM, Cianfarani F, Madonna S, Caravella S, Albanesi C, Novellino E, Marasco D
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Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2017 May 04; 138: 106-115.
Impact Factor: 3.188
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
* A Synthetic MUC1 Glycopeptide Bearing betaGalNAc-Thr as a Tn Antigen Isomer Induces the Production of Antibodies against Tumor Cells (1304 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2017 Mar 16; 18(6): 527-538.
Impact Factor: 2.774
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (448 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (528 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
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Foca A, Sanguigno L, Foca G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A
* New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (725 views) (PDF 265 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Sep 7; 16(9): 21342-21362.
Impact Factor: 3.257
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Colucci-D'Amato L, Cicatiello AE, Reccia MG, Volpicelli F, Severino V, Russo R, Sandomenico A, Doti N, D'Esposito V, Formisano P, Chambery A
* A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells (588 views)
Proteomics (ISSN: 1615-9853), 2015 Feb; 15(4): 714-724.
Impact Factor: 4.079
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Calvanese L, Sandomenico A, Caporale A, Foca A, Foca G, D'Auria G, Falcigno L, Ruvo M
* Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments (505 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015 Jan 15; 21(4): 283-293.
Impact Factor: 1.951
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GrassoG, Satriano C, Milardi D
* A neglected modulator of insulin-degrading enzyme activity and conformation: The pH (409 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2015; 203-204: 33-40.
Impact Factor: 2.363
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Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (517 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
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Falcigno L, D'Auria G, Calvanese L, Marasco D, Iacobelli R, Scognamiglio PL, Brun P, Danesin R, Pasqualin M, Castagliuolo I, Dettin M
* Osteogenic properties of a short BMP-2 chimera peptide (593 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(9): 700-709.
Impact Factor: 1.951
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Marasco D, Messori L, Marzo T, Merlino A
* Oxaliplatin vs. cisplatin: Competition experiments on their binding to lysozyme (724 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(22): 10392-10398.
Impact Factor: 4.177
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Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (464 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2015; 16(11): 1629-1636.
Impact Factor: 2.85
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (527 views)
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Impact Factor: 2.963
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Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
* Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis (478 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Jul; 101(7): 712-719.
Impact Factor: 2.385
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Improta R
* Quantum mechanical calculations unveil the structure and properties of the absorbing and emitting excited electronic states of guanine quadruplex (558 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jun 23; 20(26): 8106-8115.
Impact Factor: 5.731
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Roviello GN, Musumeci D, D'Alessandro C, Pedone C
* Binding ability of a thymine-functionalized oligolysine towards nucleic acids (347 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 997-1002.
Impact Factor: 2.793
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Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (365 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
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Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F
* A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex (610 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Feb; 70(2): 362-370.
Impact Factor: 7.232
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Pica A, Russo Krauss I, Merlino A, Nagatoishi S, Sugimoto N, Sica F
* Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer (465 views)
Febs Journal (ISSN: 1742-464x), 2013 Dec; 280(24): 6581-6588.
Impact Factor: 3.986
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Cantisani M, Falanga A, Incoronato N, Russo L, De Simone A, Morelli G, Berisio R, Galdiero M, Galdiero S
* Conformational modifications of gB from herpes simplex virus type 1 analyzed by synthetic peptides (704 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8366-8376.
Impact Factor: 5.48
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (1110 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Sandomenico A, Severino V, Chambery A, Focà A, Focà G, Farina C, Ruvo M
* A Comparative Structural and Bioanalytical Study of IVIG Clinical Lots (474 views)
Mol Biotechnol (ISSN: 1073-6085, 1559-0305electronic, 1073-6085linking), 2013 Jul; 54(3): 983-995.
Impact Factor: 2.275
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Russo Krauss I, Merlino A, Vergara A, Sica F
* An overview of biological macromolecule crystallization (1120 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 May 31; 14(6): 11643-11691.
Impact Factor: 2.339
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (471 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (402 views)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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Causa F, Della Moglie R, Iaccino E, Mimmi S, Marasco D, Scognamiglio PL, Battista E, Palmieri C, Cosenza C, Sanguigno L, Quinto I, Scala G, Netti PA
* Evolutionary screening and adsorption behavior of engineered M13 bacteriophage and derived dodecapeptide for selective decoration of gold interfaces (415 views)
J Colloid Interface Sci (ISSN: 0021-9797, 1095-7103electronic, 0021-9797linking), 2013 Jan 1; 389(1): 220-229.
Impact Factor: 1.646
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D'Agata R, Spoto G
* Surface plasmon resonance imaging for nucleic acid detection (361 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 573-584.
Impact Factor: 3.578
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (554 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (469 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
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Zanoli LM, D'Agata R, Spoto G
* Functionalized gold nanoparticles for ultrasensitive DNA detection (402 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2012 Feb; 402(5): 1759-1771.
Impact Factor: 3.659
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Pilla P, Sandomenico A, Malachovsk V, Borriello A, Giordano M, Cutolo A, Ruvo M, Cusano A
* A protein-based biointerfacing route toward label-free immunoassays with long period gratings in transition mode (473 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic, 0956-5663linking), 2012 Jan 15; 31(1): 486-491.
Impact Factor: 5.437
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* GSM48878: CD8 IL2-D2 (393 views)
Gene Expression Omnibus, 2011 Dec 2; 59(2): 302-308.
Impact Factor: 2.082
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D'Errico G, Ercole C, Lista M, Pizzo E, Falanga A, Galdiero S, Spadaccini R, Picone D
* Enforcing the positive charge of N-termini enhances membrane interaction and antitumor activity of bovine seminal ribonuclease (558 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Dec; 1808(12): 3007-3015.
Impact Factor: 3.99
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D'Agata R, Breveglieri G, Zanoli LM, Borgatti M, Spoto G, Gambari R
* Direct Detection of Point Mutations in Nonamplified Human Genomic DNA (807 views)
Analytical Chemistry (ISSN: 0003-2700), 2011 Nov 15; 83(22): 8711-8717.
Impact Factor: 5.856
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Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, Puca A, Pedone C, Scala G, Quinto I, Marasco D
* Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (603 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
Impact Factor: 3.022
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Esposito C, Marasco D, Delogu G, Pedone E, Berisio R
* Heparin-binding hemagglutinin HBHA from Mycobacterium tuberculosis affects actin polymerisation (362 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2011 Jul 1; 410(2): 339-344.
Impact Factor: 2.484
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Scognamiglio PL, Doti N, Grieco P, Pedone C, Ruvo M, Marasco D
* Discovery Of Small Peptide Antagonists Of Ped/Pea15-D4alpha Interaction From Simplified Combinatorial Libraries (504 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 May; 77(5): 319-327.
Impact Factor: 2.282
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Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G
* Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions (415 views)
Nucleic Acids Res (ISSN: 1362-4962, 0305-1048, 1362-4962electronic), 2010 Dec; 38(22): 8239-8256.
Impact Factor: 7.836
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Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (596 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (615 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (471 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA (434 views)
Lect Notes Electr Eng, 2010 May 15; 91LNEE: 485-488.
Impact Factor: 0
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (425 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
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Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
* Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (557 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0005-2736, 0925-4439), 2010 Mar; 1798(3): 579-591.
Impact Factor: 4.647
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D'Agata R, Breveglieri G, Zanoli L, Borgatti M, Spoto G, Gambari R
* Surface Plasmon Resonance Imaging (SPR-I), peptide nucleic acid (PNA) probes and nanoparticle-enhancement for PCR-free ultrasensitive detection of beta-thalassemia mutations in human genomic DNA (298 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2010; 26: N/D-N/D.
Impact Factor: 1.814
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Sandomenico A, Monti SM, Marasco D, Dathan N, Palumbo R, Saviano M, Ruvo M
* Ige-Binding Properties And Selectivity Of Peptide Mimics Of The Fcvarepsilonri Binding Site (1651 views)
Mol Immunol (ISSN: 0161-5890), 2009 Oct; 46(16): 3300-3309.
Impact Factor: 3.202
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Grasso G, D'Agata R, Zanoli L, Spoto G
* Microfluidic networks for surface plasmon resonance imaging real-time kinetics experiments (271 views)
Microchemical Journal (ISSN: 0026-265x), 2009 Sep; 93(1): 82-86.
Impact Factor: 2.579
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Grasso G, Bush AI, D'Agata R, Rizzarelli E, Spoto G
* Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme (601 views)
Eur Biophys J (ISSN: 1432-1017, 0175-7571, 0175-7571linking), 2009 Apr; 38(4): 407-414.
Impact Factor: 2.437
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (460 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (437 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (412 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Grasso G, Rizzarelli E, Spoto G
* How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin (354 views)
Bba-Gen Subjects (ISSN: 0006-3002, 1570-9639, 0925-4439), 2008 Jul; 1784(7-8): 1122-1126.
Impact Factor: 2.233
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Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M
* Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (446 views)
Protein Expr Purif (ISSN: 1046-5928), 2008 Jun; 59(2): 302-308.
Impact Factor: 1.621
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Rossi M, Ruvo M, Marasco D, Colombo M, Cassani G, Verdoliva A
* Anti-allergic properties of a new all-D synthetic immunoglobulin-binding peptide (431 views)
Mol Immunol (ISSN: 0161-5890), 2008 Jan; 45(1): 226-234.
Impact Factor: 3.555
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Zanoli L, Dagata R, Spoto G
* Surface plasmon-based optical detection of DNA peptide nucleic acids (262 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 165-174.
Impact Factor: 0.1
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (359 views)
Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
Impact Factor: 3.664
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases (433 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.
Impact Factor: 2.945
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D'Agata R, Grasso G, Iacono G, Spoto G, Vecchio G
* Lectin recognition of a new SOD mimic bioconjugate studied with surface plasmon resonance imaging (303 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2006 Feb 21; 4(4): 610-612.
Impact Factor: 2.874
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Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (577 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
Impact Factor: 3.574
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Arena G, Contino A, D'Agata R, Sgarlata C, Spoto G
* Ordered anchored cavities at work: A new and rapid SPR-based method for the detection of trace amounts of Cs+ (421 views)
New J Chem (ISSN: 1144-0546), 2005; 29(11): 1393-1395.
Impact Factor: 2.574
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68 Records (66 excluding Abstracts).
Total impact factor: 244.869 (243.055 excluding Abstracts).
Total 5 year impact factor: 251.373 (249.554 excluding Abstracts).
Total impact factor: 244.869 (243.055 excluding Abstracts).
Total 5 year impact factor: 251.373 (249.554 excluding Abstracts).
577 views. Last view on Saturday 10 June 2023, 13:52:44
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