Keywords: β-Amyloid, Alzheimer, S Disease, Insulin, Insulin-Like Growth Factor 1, Amyloid Beta Protein, Oligomer, Somatomedin C Receptor, Alzheimer Disease, Article, Cell Membrane, Cognitive Reserve, Down Regulation, Human, Hyperinsulinemia, Protein Depletion, Protein Expression, Protein Function, Protein Protein Interaction, Signal Transduction, Animal, Metabolism, Pathology, Review, Amyloid Beta-Peptides, Alzheimer Disease Metabolism Pathology, Amyloid Beta-Peptides Metabolism, Brain Metabolism Pathology, Insulin Metabolism, Insulin-Like Growth Factor I Metabolism, ß-Amyloid,
Affiliations: *** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council, Viale Andrea Doria, Catania 95125, Italy
PhD Program in Neuropharmacology, University of Catania, Viale Andrea Doria, Catania 95125, Italy
Department of Formative Processes, University of Catania, Via Biblioteca 2, Catania 95100, Italy
Department of Drug Sciences, University of Catania, Viale Andrea Doria, Catania 95125, Italy
Department of Human Physiology and Pharmacology, University of Rome la Sapienza, Piazzale Aldo Moro, Rome 00185, Italy
Instituto Neurologico Mediterraneo, Neuromed Località Camerelle, Pozzilli 86077, Italy
References: Burns, A., Byrne, E.J., Maurer, K., Alzheimer's disease (2002) Lancet, 360, pp. 163-165. , 12126840 10.1016/S0140-6736(02)09420-
Selkoe, D.J., Resolving controversies on the paths to Alzheimer's therapeutics (2011) Nat Med, 17, pp. 1060-1065. , 21900936 1:CAS:528:DC%2BC3MXhtFCntL7E 10.1038/nm.2460
Karran, E., Mercken, M., De Strooper, B., The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics (2011) Nat Rev Drug Discov, 10, pp. 698-712. , 21852788 1:CAS:528:DC%2BC3MXhtVelsL3L 10.1038/nrd3505
Barron, A.M., Pike, C.J., Sex hormones, aging, and Alzheimer's disease (2012) Front Biosci (Elite Ed), 4, pp. 976-997
Piriz, J., Muller, A., Trejo, J.L., Torres-Aleman, I., IGF-I and the aging mammalian brain (2011) Exp Gerontol, 46, pp. 96-99. , 20863877 1:CAS:528:DC%2BC3MXpvV2nsA%3D%3D 10.1016/j.exger.2010.08.022
Ledesma, M.D., Dotti, C.G., Peripheral cholesterol, metabolic disorders and Alzheimer's disease (2012) Front Biosci (Elite Ed), 4, pp. 181-194
De La Monte, S.M., Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease (2012) Drugs, 72, pp. 49-66. , 22191795 10.2165/11597760-000000000-00000
Stranahan, A.M., Mattson, M.P., Metabolic reserve as a determinant of cognitive aging (2011) J Alzheimers Dis, 28, pp. 1-9
Ristow, M., Neurodegenerative disorders associated with diabetes mellitus (2004) J Mol Med (Berl), 82, pp. 510-529. , 10.1007/s00109-004-0552-1
Caselli, R.J., Chen, K., Lee, W., Alexander, G.E., Reiman, E.M., Correlating cerebral hypometabolism with future memory decline in subsequent converters to amnestic pre-mild cognitive impairment (2008) Arch Neurol, 65, pp. 1231-1236. , 18779428 10.1001/archneurol.2008.1
Schulingkamp, R.J., Pagano, T.C., Hung, D., Raffa, R.B., Insulin receptors and insulin action in the brain: Review and clinical implications (2000) Neurosci Biobehav Rev, 24, pp. 855-872. , 11118610 1:CAS:528:DC%2BD3cXoslCks7k%3D 10.1016/S0149-7634(00)00040-3
Schechter, R., Whitmire, J., Holtzclaw, L., George, M., Harlow, R., Devaskar, S.U., Developmental regulation of insulin in the mammalian central nervous system (1992) Brain Res, 582, pp. 27-37. , 1482442 1:CAS:528:DyaK38XltVCksrs%3D 10.1016/0006-8993(92)90313-X
Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., Vigneri, R., Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease (2009) Endocr Rev, 30, pp. 586-623. , 19752219 1:CAS:528:DC%2BD1MXhsVyhsrbK 10.1210/er.2008-0047
Pandini, G., Frasca, F., Mineo, R., Sciacca, L., Vigneri, R., Belfiore, A., Insulin/insulin-like growth factor i hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved (2002) J Biol Chem, 277, pp. 39684-39695. , 12138094 1:CAS:528:DC%2BD38XnvVeiu74%3D 10.1074/jbc.M202766200
Craft, S., Stennis Watson, G., Insulin and neurodegenerative disease: Shared and specific mechanisms (2004) Lancet, 3, pp. 169-178. , 1:CAS:528:DC%2BD2cXjtVCqtLg%3D 10.1016/S1474-4422(04)00681-7
Park, C.R., Seeley, R.J., Craft, S., Woods, S.C., Intracerebroventricular insulin enhances memory in a passive-avoidance task (2000) Physiol Behav, 68, pp. 509-514. , 10713291 1:CAS:528:DC%2BD3cXhsFGqtbo%3D 10.1016/S0031-9384(99)00220-6
Werther, G.A., Hogg, A., Oldfiedl, B.J., McKinley, M.J., Figdor, R., Allen, A.M., Mendelsohn, F.A.O., Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry (1987) Endocrinology, 121, pp. 1562-1570. , 3653038 1:CAS:528:DyaL2sXmt12ltLc%3D 10.1210/endo-121-4-1562
Abbott, M.A., Wells, D.G., Fallon, J.R., The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses (1999) J Neurosci, 19, pp. 7300-7308. , 10460236 1:CAS:528:DyaK1MXlslWnu78%3D
Zhao, W.-T., Alkon, D.L., Role of insulin and insulin receptor in learning and memory (2001) Mol Cell Endocrinol, 177, pp. 125-134. , 11377828 1:CAS:528:DC%2BD3MXjslSktLc%3D 10.1016/S0303-7207(01)00455-5
Lucignani, G., Namba, H., Nehlig, A., Porrino, L., Kennedy, C., Sokoloff, L., Effects of insulin on local cerebral glucose utilization in the rat (1987) J Cereb Blood Flow Metab, 7, pp. 309-314. , 3294864 1:CAS:528:DyaL2sXksFamt7w%3D 10.1038/jcbfm.1987.68
Doyle, P., Cusin, I., Rohner-Jeanrenaud, F., Jeanrenaud, B., Four-day hyperinsulinemia in euglycemic conditions alters local cerebral glucose utilization in specific brain nuclei of freely moving rats (1995) Brain Res, 684, pp. 47-55. , 7583203 1:CAS:528:DyaK2MXms1ylsro%3D 10.1016/0006-8993(95)00402-C
Livingstone, C., Lyall, H., Gould, G., Hypothalamic GLUT4 expression: A glucose- and insulin-sensing mechanism? (1995) Mol Cell Endocrinol, 107, pp. 67-70. , 7796936 1:CAS:528:DyaK2MXis12murw%3D 10.1016/0303-7207(94)03423-Q
Apelt, J., Mehlhorn, G., Schliebs, R., Insulin-sensitive GLUT4 glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neuron-specific localization in rat brain (1999) J Neurosci Res, 57, pp. 693-705. , 10462693 1:CAS:528:DyaK1MXmtVWlt7o%3D 10.1002/(SICI)1097-4547(19990901) 57:5<693: AID-JNR11>
3.0.CO
McEwen, B.S., Reagan, L.P., Glucose transporter expression in the central nervous system: Relationship to synaptic function (2004) Eur J Pharmacol, 490, pp. 13-24. , 15094070 1:CAS:528:DC%2BD2cXjt1ShsLg%3D 10.1016/j.ejphar.2004.02.041
Summers, S.A., Kao, A.W., Kohn, A.D., Backus, G.S., Roth, R.A., Pessin, J.E., Birnbaum, M.J., The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism (1999) J Biol Chem, 274, pp. 17934-17940. , 10364240 1:CAS:528:DyaK1MXktVylsb4%3D 10.1074/jbc.274.25.17934
Taniguchi, C.M., Emanuelli, B., Kahn, C.R., Critical nodes in signalling pathways: Insights into insulin action (2006) Nat Rev Mol Cell Biol, 7, pp. 85-96. , 16493415 1:CAS:528:DC%2BD28XhtlWnsLw%3D 10.1038/nrm1837
Bondy, C.A., Cheng, C.M., Signaling by insulin-like growth factor 1 in brain (2004) Eur J Pharmacol, 490, pp. 25-31. , 15094071 1:CAS:528:DC%2BD2cXjt1ShsLY%3D 10.1016/j.ejphar.2004.02.042
Bailyes, E.M., Navé, B.T., Soos, M.A., Orr, S.R., Hayward, A.C., Siddle, K., Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: Quantification of individual receptor species by selective immunoprecipitation and immunoblotting (1997) Biochem J, 327, pp. 209-215. , 9355755 1:CAS:528:DyaK2sXmvVGktrw%3D
Soos, M.A., Field, C.E., Siddle, K., Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity (1993) Biochem J, 290, pp. 419-426. , 8452530 1:CAS:528:DyaK3sXhvVeqtLw%3D
Kasuya, J., Paz, I.B., Maddux, B.A., Goldfine, I.D., Hefta, S.A., Fujita-Yamaguchi, Y., Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification (1993) Biochemistry, 32, pp. 13531-13536. , 8257688 1:CAS:528:DyaK3sXms1alur4%3D 10.1021/bi00212a019
Bondy, C., Werner, H., Roberts, Jr.C.T., Leroith, D., Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors i and II (1992) Neuroscience, 46, pp. 909-923. , 1311816 1:CAS:528:DyaK38Xht1Wrsrw%3D 10.1016/0306-4522(92)90193-6
Torres-Aleman, I., Towards a comprehensive neurobiology of IGF-1 (2010) Dev Neurobiol, 70, pp. 384-396. , 20186710 1:CAS:528:DC%2BC3cXlvVKit7w%3D
Aberg, M.A., Aberg, N.D., Hedbäcker, H., Oscarsson, J., Eriksson, P.S., Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus (2000) J Neurosci, 20, pp. 2896-2903. , 10751442 1:CAS:528:DC%2BD3cXisVertLY%3D
Nunez, A., Carro, E., Torres-Aleman, I., Insulin-like growth factor i modifies electrophysiological properties of rat brain stem neurons (2003) J Neurophysiol, 89, pp. 3008-3017. , 12612011 1:CAS:528:DC%2BD3sXlsFajur4%3D 10.1152/jn.00089.2003
Trejo, J.L., Carro, E., Nunez, A., Torres-Aleman, I., Sedentary life impairs self-reparative processes in the brain: The role of serum insulin-like growth factor-I (2002) Rev Neurosci, 13, pp. 365-374. , 12542262 1:CAS:528:DC%2BD3sXotVeqsw%3D%3D
Nishijima, T., Piriz, J., Duflot, S., Fernandez, A.M., Gaitan, G., Gomez-Pinedo, U., Verdugo, J.M., Torres-Aleman, I., Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS (2010) Neuron, 67, pp. 834-846. , 20826314 1:CAS:528:DC%2BC3cXhtFamtb%2FF 10.1016/j.neuron.2010.08.007
Fernandez, A.M., Kim, J.K., Yakar, S., Dupont, J., Hernandez-Sanchez, C., Castle, A.L., Filmore, J., Le Roith, D., Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes (2001) Genes Dev, 15, pp. 1926-1934. , 11485987 1:CAS:528:DC%2BD3MXlvFertrs%3D 10.1101/gad.908001
Denley, A., Carroll, J.M., Brierley, G.V., Cosgrove, L., Wallace, J., Forbes, B., Roberts, Jr.C.T., Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors (2007) Mol Cell Biol, 27, pp. 3569-3577. , 17325037 1:CAS:528:DC%2BD2sXltlansbs%3D 10.1128/MCB.01447-06
Russo, V.C., Gluckman, P.D., Feldman, E.L., Werther, G.A., The insulin-like growth factor system and its pleiotropic functions in brain (2005) Endocr Rev, 26, pp. 916-943. , 16131630 1:CAS:528:DC%2BD28XktVygtA%3D%3D 10.1210/er.2004-0024
Frolich, L., Blum-Degen, D., Bernstein, H.G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Riederer, P., Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease (1998) J Neural Transm, 105, pp. 423-438. , 9720972 1:CAS:528:DyaK1cXmvFSqtbw%3D 10.1007/s007020050068
Steen, E., Terry, B.M., Rivera, E.J., Cannon, J.L., Neely, T.R., Tavares, R., Xu, X.J., De La Monte, S.M., Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - Is this type 3 diabetes? (2005) J Alzheimers Dis, 7, pp. 63-80. , 15750215 1:CAS:528:DC%2BD2MXhvVSrtL8%3D
Hoyer, S., The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: An update (2002) J Neural Transm, 109, pp. 341-360. , 11956956 1:CAS:528:DC%2BD38XktF2gsrg%3D 10.1007/s007020200028
Moloney, A.M., Griffin, R.J., Timmons, S., O'Connor, R., Ravid, R., O'Neill, C., Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling (2010) Neurobiol Aging, 31, pp. 224-243. , 18479783 1:CAS:528:DC%2BD1MXhsFGrsL3O 10.1016/j.neurobiolaging.2008.04. 002
Kappeler, L., De Magalhaes Filho, C.M., Dupont, J., Leneuve, P., Cervera, P., Perin, L., Loudes, C., Holzenberger, M., Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism (2008) PLoS Biol, 6, p. 254. , 18959478 10.1371/journal.pbio.0060254
Schubert, M., Gautam, D., Surjo, D., Ueki, K., Baudler, S., Schubert, D., Kondo, T., Brüning, J.C., Role for neuronal insulin resistance in neurodegenerative diseases (2004) Proc Natl Acad Sci USA, 101, pp. 3100-3105. , 14981233 1:CAS:528:DC%2BD2cXitlWht7Y%3D 10.1073/pnas.0308724101
Park, S.A., A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: Evidence from animal models (2011) J Clin Neurol, 7, pp. 10-18. , 21519521 10.3988/jcn.2011.7.1.10
Lannfelt, L., Folkesson, R., Mohammed, A.H., Winblad, B., Hellgren, D., Duff, K., Hardy, J., Alzheimer's disease: Molecular genetics and transgenic animal models (1993) Behav Brain Res, 57, pp. 207-213. , 8117426 1:CAS:528:DyaK2cXis1Kqsrs%3D 10.1016/0166-4328(93)90137-F
Ott, A., Stolk, R.P., Van Harskamp, F., Pols, H.A., Hofman, A., Breteler, M.M., Diabetes mellitus and the risk of dementia: The rotterdam study (1999) Neurology, 53, pp. 1937-1942. , 10599761 1:STN:280:DC%2BD3c%2Fms1Ontg%3D%3D 10.1212/WNL.53.9.1937
Salkovic-Petrisic, M., Tribl, F., Schmidt, M., Hoyer, S., Riederer, P., Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway (2006) J Neurochem, 96, pp. 1005-1015. , 16412093 1:CAS:528:DC%2BD28XivFWjsr8%3D 10.1111/j.1471-4159.2005.03637.x
Grünblatt, E., Hoyer, S., Riederer, P., Gene expression profile in streptozotocin rat model for sporadic Alzheimer's disease (2004) J Neural Transm, 111, pp. 367-386. , 14991460 10.1007/s00702-003-0030-x
Grünblatt, E., Salkovic-Petrisic, M., Osmanovic, J., Riederer, P., Hoyer, S., Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein (2007) J Neurochem, 101, pp. 757-770. , 17448147 10.1111/j.1471-4159.2006.04368.x
Plaschke, K., Kopitz, J., Siegelin, M., Schliebs, R., Salkovic-Petrisic, M., Riederer, P., Hoyer, S., Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 abetaPP-overexpressing mice (2010) J Alzheimers Dis, 19, pp. 691-704. , 20110613 1:CAS:528:DC%2BC3cXht1SltL4%3D
Cirrito, J.R., May, P.C., O'Dell, M.A., Taylor, J.W., Parsadanian, M., Cramer, J.W., Audia, J.E., Holtzman, D.M., In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life J Neurosci, 23, pp. 8844-8853
MacKic, J.B., Stins, M., McComb, J.G., Calero, M., Ghiso, J., Kim, K.S., Yan, S.D., Zlokovic, B.V., Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer (1998) J Clin Invest, 102, pp. 734-743. , 9710442 1:CAS:528:DyaK1cXlsFaru7o%3D 10.1172/JCI2029
Eckman, E.A., Eckman, C.B., Abeta-degrading enzymes: Modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention (2005) Biochem Soc Trans, 33, pp. 1101-1105. , 16246055 1:CAS:528:DC%2BD2MXhtFCqs7nK 10.1042/BST20051101
Qiu, W.Q., Folstein, M.F., Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: Review and hypothesis (2006) Neurobiol Aging, 27, pp. 190-198. , 16399206 1:CAS:528:DC%2BD28XitFClsg%3D%3D 10.1016/j.neurobiolaging.2005. 01.004
Nag, S., Sarkar, B., Bandyopadhyay, A., Sahoo, B., Sreenivasan, V.K., Kombrabail, M., Muralidharan, C., Maiti, S., Nature of the amyloid-beta monomer and the monomer-oligomer equilibrium (2011) J Biol Chem, 286, pp. 13827-13833. , 21349839 1:CAS:528:DC%2BC3MXkslWjt7k%3D 10.1074/jbc.M110.199885
De Meyer, G., Shapiro, F., Vanderstichele, H., Vanmechelen, E., Engelborghs, S., De Deyn, P.P., Coart, E., Trojanowski, J.Q., Alzheimer's disease neuroimaging initiative (2010) Arch Neurol, 67, pp. 949-956. , 20697045 10.1001/archneurol.2010.179
Teplow, D.B., Structural and kinetic features of amyloid beta-protein fibrillogenesis (1998) Amyloid, 5, pp. 121-142. , 9686307 1:CAS:528:DyaK1cXkvVensLw%3D 10.3109/13506129808995290
Lue, L.F., Kuo, Y.M., Roher, A.E., Brachova, L., Shen, Y., Sue, L., Beach, T., Rogers, J., Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease (1999) Am J Pathol, 155, pp. 853-862. , 10487842 1:STN:280:DyaK1MvhvFarsA%3D%3D 10.1016/S0002-9440(10)65184-X
Townsend, M., Shankar, G.M., Mehta, T., Walsh, D.M., Selkoe, D.J., Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: A potent role for trimers (2006) J Physiol, 572, pp. 477-492. , 16469784 1:CAS:528:DC%2BD28XksV2jtrc%3D 10.1113/jphysiol.2005.103754
Walsh, D.M., Klyubin, I., Fadeeva, J.V., Cullen, W.K., Anwyl, R., Wolfe, M.S., Rowan, M.J., Selkoe, D.J., Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo (2002) Nature, 416, pp. 535-539. , 11932745 1:CAS:528:DC%2BD38XivVOntL8%3D 10.1038/416535a
Klyubin, I., Walsh, D.M., Lemere, C.A., Cullen, W.K., Shankar, G.M., Betts, V., Spooner, E.T., Rowan, M.J., Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo (2005) Nat Med, 11, pp. 556-561. , 15834427 1:CAS:528:DC%2BD2MXjvVOls74%3D 10.1038/nm1234
Lesne, S., Koh, M.T., Kotilinek, L., Kayed, R., Glabe, C.G., Yang, A., Gallagher, M., Ashe, K.H., A specific amyloid-beta protein assembly in the brain impairs memory (2006) Nature, 440, pp. 352-357. , 16541076 1:CAS:528:DC%2BD28XitlKgurg%3D 10.1038/nature04533
Copani, A., Guccione, S., Giurato, L., Caraci, F., Calafiore, M., Sortino, M.A., Nicoletti, F., The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (2008) Curr Med Chem, 15, pp. 2420-2432. , 18855671 1:CAS:528:DC%2BD1cXhtFCqsLbP 10.2174/092986708785909030
Fändrich, M., Oligomeric intermediates in amyloid formation: Structure determination and mechanisms of toxicity (2012) J Mol Biol, , doi: 10.1016/j.jmb.2012.01.006
Plant, L.D., Boyle, J.P., Smith, I.F., Peers, C., Pearson, H.A., The production of amyloid beta peptide is a critical requirement for the viability of central neurons (2003) J Neurosci, 23, pp. 5531-5535. , 12843253 1:CAS:528:DC%2BD3sXltl2qs7Y%3D
Soucek, T., Cumming, R., Dargusch, R., Maher, P., Schubert, D., The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide (2003) Neuron, 39, pp. 43-56. , 12848931 1:CAS:528:DC%2BD3sXlsV2ku7s%3D 10.1016/S0896-6273(03)00367-2
Whitson, J.S., Selkoe, D.J., Cotman, C.W., Amyloid beta protein enhances the survival of hippocampal neurons in vitro (1989) Science, 243, pp. 1488-1490. , 2928783 1:CAS:528:DyaL1MXitFShtL4%3D 10.1126/science.2928783
Harrison, S.M., Harper, A.J., Hawkins, J., Duddy, G., Grau, E., Pugh, P.L., Winter, P.H., Dingwall, C., BACE1 (beta-secretase) transgenic and knockout mice: Identification of neurochemical deficits and behavioral changes (2203) Mol Cell Neurosci, 24, pp. 646-655. , 10.1016/S1044-7431(03)00227-6
Ohno, M., Sametsky, E.A., Younkin, L.H., Oakley, H., Younkin, S.G., Citron, M., Vassar, R., Disterhoft, J.F., BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease (2004) Neuron, 41, pp. 27-33. , 14715132 1:CAS:528:DC%2BD2cXnt12mtg%3D%3D 10.1016/S0896-6273(03)00810-9
Wang, H., Song, L., Laird, F., Wong, P.C., Lee, H.K., BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus (2008) J Neurosci, 28, pp. 8677-8681. , 18753368 1:CAS:528:DC%2BD1cXhtVyksL%2FK 10.1523/JNEUROSCI.2440-08.2008
Puzzo, D., Privitera, L., Leznik, E., Fa, M., Staniszewski, A., Palmeri, A., Arancio, O., Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus (2008) J Neurosci, 28, pp. 14537-14545. , 19118188 1:CAS:528:DC%2BD1MXnsF2msw%3D%3D 10.1523/JNEUROSCI.2692-08.2008
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., Malinow, R., APP processing and synaptic function (2003) Neuron, 37, pp. 925-937. , 12670422 1:CAS:528:DC%2BD3sXivFWkurY%3D 10.1016/S0896-6273(03)00124-7
Abramov, E., Dolev, I., Fogel, H., Ciccotosto, G.D., Ruff, E., Slutsky, I., Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses (2009) Nat Neurosci, 12, pp. 1567-1576. , 19935655 1:CAS:528:DC%2BD1MXhsVGlur%2FP 10.1038/nn.2433
Gasparini, L., Gouras, G.K., Wang, R., Gross, R.S., Beal, M.F., Greengard, P., Xu, H., Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling (2001) J Neurosci, 21, pp. 2561-2570. , 11306609 1:CAS:528:DC%2BD3MXjtVWkurs%3D
Sudoh, S., Frosch, M.P., Wolf, B.A., Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells (2002) Biochemistry, 41, pp. 1091-1099. , 11802707 1:CAS:528:DC%2BD38XlvV2k 10.1021/bi011193l
Zhao, L., Teter, B., Morihara, T., Lim, G.P., Ambegaokar, S.S., Ubeda, O.J., Frautschy, S.A., Cole, G.M., Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: Implications for Alzheimer's disease intervention (2004) J Neurosci, 24, pp. 11120-11126. , 15590928 1:CAS:528:DC%2BD2cXhtFagurfP 10.1523/JNEUROSCI.2860-04.2004
Carro, E., Trejo, J.L., Gomez-Isla, T., Leroith, D., Torres-Aleman, I., Serum insulin-like growth factor i regulates brain amyloid-beta levels (2002) Nat Med, 8, pp. 1390-1397. , 12415260 1:CAS:528:DC%2BD38XptVSgsb0%3D 10.1038/nm1202-793
Craft, S., Peskind, E., Schwartz, M.W., Schellenberg, G.D., Raskind, M., Porte, Jr.D., Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein e genotype (1998) Neurology, 50, pp. 164-168. , 9443474 1:CAS:528:DyaK1cXotVKgug%3D%3D 10.1212/WNL.50.1.164
Giuffrida, M.L., Caraci, F., Pignataro, B., Cataldo, S., De Bona, P., Bruno, V., Molinaro, G., Copani, A., Beta-amyloid monomers are neuroprotective (2009) J Neurosci, 29, pp. 10582-10587. , 19710311 1:CAS:528:DC%2BD1MXhtVyntr3I 10.1523/JNEUROSCI.1736-09.2009
Willert, K., Nusse, R., Beta-catenin: A key mediator of Wnt signaling (1998) Curr Opin Genet Dev, 8, pp. 95-102. , 9529612 1:CAS:528:DyaK1cXit1Gmt78%3D 10.1016/S0959-437X(98)80068-3
Rankin, C.A., Sun, Q., Gamblin, T.C., Tau phosphorylation by GSK-3beta promotes tangle-like filament morphology (2007) Mol Neurodegener, 2, p. 12. , 17598919 10.1186/1750-1326-2-12
Liu, F., Shi, J., Tanimukai, H., Gu, J., Gu, J., Grundke-Iqbal, I., Iqbal, K., Gong, C.X., Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease (2009) Brain, 132, pp. 1820-1832. , 19451179 10.1093/brain/awp099
Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease
Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G * Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation(849 views) Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806. Impact Factor:8.017 ViewExport to BibTeXExport to EndNote