Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (393 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Abstract, Conference,
Impact factor: 1.938, 5-year impact factor: 4.97
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-4143105541&partnerID=40&md5=e88a3510b56cbb8a8db68f0b4e3c6f20
Keywords: Acrylic Acid Resin, Cation, Didodecyldimethylammonium, Drug Carrier, Eudragit Rs, Luciferase, Nucleic Acid, Peptide Nucleic Acid, Quaternary Ammonium Derivative, Surfactant, Adenocarcinoma, Animal, Article, Biosynthesis, Breast Tumor, Cell Culture, Chemistry, Colloid, Drug Stability, Female, Genetic Transfection, Human, Macrophage, Methodology, Mouse, Particle Size, Pathology, Reporter Gene, Tumor Cell Line, Acrylic Resins, Breast Neoplasms, Quaternary Ammonium Compounds, Surface-Active Agents, Delivery, Submicron Particles, Benzethonium Chloride, Cationic Surfactant, Domiphen Bromide, Lipofectamine, Liposome, Polymer, Animal Cell, Cell Growth, Cell Interaction, Cell Proliferation, Cell Strain K 562, Complex Formation, Controlled Study, Cytotoxicity, Drug Delivery System, Drug Formulation, Drug Storage, Drug Synthesis, Drug Transport, Electron Microscopy, Enzyme Activity, Enzyme Assay, Gene Targeting, Human Cell, In Vitro Study, Intermethod Comparison, Nonhuman, Physical Chemistry, Scanning Electron Microscopy, Spray Drying, Zeta Potential,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy.
Dept. of Biochemistry/Molec. Biology, University of Ferrara, Ferrara, Italy
Institute of Biostructure/Bioimaging, CNR, Napoli, France
Lab. Devmt. Pharmacol./Pharmacogen., Biotechnology Centre, University of Ferrara, Ferrara, Italy
Dept. of Pharmaceut. Chem./Technol., University of Perugia, Perugia, Italy
References:
Nielsen, P.E., Egholm, M., Berg, R.H., Buchardt, O., Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide (1991) Science, 254, pp. 1497-150
Egholm, M., Buchardt, O., Nielsen, P.E., Berg, R.H., Peptide nucleic acids (PNA): Oligonucleotide analogues with an achiral peptide backbone (1992) J. Am. Chem. Soc., 114, pp. 1895-1897
Gambari, R., Peptide nucleic acids (PNAs): A tool for the development of gene expression modifiers (2001) Curr. Pharm. Design, 7, pp. 1839-1862
Demidov, V.V., Potaman, V.N., Frank-Kamenetsk, M.D., Stability of peptide nucleic acids in human serum and cellular extracts (1994) Biochem. Pharmacol., 48, pp. 1310-1313
Scarfì, S., Giovine, M., Gasparini, A., Modified peptide nucleic acids are internalized in mouse macrophages RAW 264.7 and inhibit inducible nitric oxide synthase (1999) FEBS Lett., 451, pp. 264-268
Nastruzzi, C., Cortesi, R., Esposito, E., Liposomes as carriers for DNA-PNA hybrids (2000) J. Control Release, 68, pp. 237-249
Vinayak, R., Van der Laan, A.C., Brill, R., Automated chemical synthesis of PNA and PNA-DNA chimera on a nucleic acid synthesizer (1997) Nucleosides Nucleotides, 16, pp. 1653-1658
Romanelli, E., Pedone, C., Saviano, M., Molecular interactions between nuclear factor kB (NF-kB) transcription factors and a PNA-DNA chimera mimicking NF-kB binding sites (2001) Eur. J. Biochem., 268, pp. 1-11
Borgatti, M., Breda, L., Cortesi, R., Cationic liposomes as delivery systems for double-stranded peptide nucleic acid (PNA)-DNA chimeras exhibiting decoy activity against nuclear factor-kB transcription factors (2002) Biochem. Pharmacol., 64, pp. 609-616
Fundueanu, G., Mocanu, G., Constantin, M., Acrylic microspheres for oral controlled release of the biguanide buformin (2001) Int. J. Pharm., 218, pp. 13-25
Esposito, E., Roncarati, R., Cortesi, R., Cervellati, F., Nastruzzi, C., Production of Eudragit microparticles by spray-drying technique: Influence of experimental parameters on morphological and dimensional characteristics (2000) Pharm. Dev. Technol., 5, pp. 267-278
Esposito, E., Sebben, S., Cortesi, R., Menegatti, E., Nastruzzi, C., Preparation and characterization of cationic microspheres for gene delivery (1999) Int. J. Pharm., 189, pp. 29-41
Zambaux, E., Faivre-Fiorina, B., Bonneaux, F., Involvement of neutrophilic granulocytes in the uptake of biodegradable non-stealth and stealth nanoparticles in guinea pig (2000) Biomaterials, 21, pp. 975-980
Fernandez-Urrusuno, R., Fattal, E., Rodrigues Jr., J.M., FeH ger, J., Bedossa, P., Couvreur, P., Effect of polymeric nanoparticle administration on the clearance activity of the mononuclear phagocyte system in mice (1996) J. Biomed. Mater. Res., 31, pp. 401-408
Esposito, E., Cortesi, R., Porta, R., Trento, F., Nastruzzi, C., Effect of long-term stabilization of cationic liposomes as defibrotide delivery system for antithrombotic activity (2002) Drug Dev. Res., 5, pp. 127-138
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Abstract, Conference,
Impact factor: 1.938, 5-year impact factor: 4.97
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-4143105541&partnerID=40&md5=e88a3510b56cbb8a8db68f0b4e3c6f20
Keywords: Acrylic Acid Resin, Cation, Didodecyldimethylammonium, Drug Carrier, Eudragit Rs, Luciferase, Nucleic Acid, Peptide Nucleic Acid, Quaternary Ammonium Derivative, Surfactant, Adenocarcinoma, Animal, Article, Biosynthesis, Breast Tumor, Cell Culture, Chemistry, Colloid, Drug Stability, Female, Genetic Transfection, Human, Macrophage, Methodology, Mouse, Particle Size, Pathology, Reporter Gene, Tumor Cell Line, Acrylic Resins, Breast Neoplasms, Quaternary Ammonium Compounds, Surface-Active Agents, Delivery, Submicron Particles, Benzethonium Chloride, Cationic Surfactant, Domiphen Bromide, Lipofectamine, Liposome, Polymer, Animal Cell, Cell Growth, Cell Interaction, Cell Proliferation, Cell Strain K 562, Complex Formation, Controlled Study, Cytotoxicity, Drug Delivery System, Drug Formulation, Drug Storage, Drug Synthesis, Drug Transport, Electron Microscopy, Enzyme Activity, Enzyme Assay, Gene Targeting, Human Cell, In Vitro Study, Intermethod Comparison, Nonhuman, Physical Chemistry, Scanning Electron Microscopy, Spray Drying, Zeta Potential,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy.
Dept. of Biochemistry/Molec. Biology, University of Ferrara, Ferrara, Italy
Institute of Biostructure/Bioimaging, CNR, Napoli, France
Lab. Devmt. Pharmacol./Pharmacogen., Biotechnology Centre, University of Ferrara, Ferrara, Italy
Dept. of Pharmaceut. Chem./Technol., University of Perugia, Perugia, Italy
References:
Nielsen, P.E., Egholm, M., Berg, R.H., Buchardt, O., Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide (1991) Science, 254, pp. 1497-150
Egholm, M., Buchardt, O., Nielsen, P.E., Berg, R.H., Peptide nucleic acids (PNA): Oligonucleotide analogues with an achiral peptide backbone (1992) J. Am. Chem. Soc., 114, pp. 1895-1897
Gambari, R., Peptide nucleic acids (PNAs): A tool for the development of gene expression modifiers (2001) Curr. Pharm. Design, 7, pp. 1839-1862
Demidov, V.V., Potaman, V.N., Frank-Kamenetsk, M.D., Stability of peptide nucleic acids in human serum and cellular extracts (1994) Biochem. Pharmacol., 48, pp. 1310-1313
Scarfì, S., Giovine, M., Gasparini, A., Modified peptide nucleic acids are internalized in mouse macrophages RAW 264.7 and inhibit inducible nitric oxide synthase (1999) FEBS Lett., 451, pp. 264-268
Nastruzzi, C., Cortesi, R., Esposito, E., Liposomes as carriers for DNA-PNA hybrids (2000) J. Control Release, 68, pp. 237-249
Vinayak, R., Van der Laan, A.C., Brill, R., Automated chemical synthesis of PNA and PNA-DNA chimera on a nucleic acid synthesizer (1997) Nucleosides Nucleotides, 16, pp. 1653-1658
Romanelli, E., Pedone, C., Saviano, M., Molecular interactions between nuclear factor kB (NF-kB) transcription factors and a PNA-DNA chimera mimicking NF-kB binding sites (2001) Eur. J. Biochem., 268, pp. 1-11
Borgatti, M., Breda, L., Cortesi, R., Cationic liposomes as delivery systems for double-stranded peptide nucleic acid (PNA)-DNA chimeras exhibiting decoy activity against nuclear factor-kB transcription factors (2002) Biochem. Pharmacol., 64, pp. 609-616
Fundueanu, G., Mocanu, G., Constantin, M., Acrylic microspheres for oral controlled release of the biguanide buformin (2001) Int. J. Pharm., 218, pp. 13-25
Esposito, E., Roncarati, R., Cortesi, R., Cervellati, F., Nastruzzi, C., Production of Eudragit microparticles by spray-drying technique: Influence of experimental parameters on morphological and dimensional characteristics (2000) Pharm. Dev. Technol., 5, pp. 267-278
Esposito, E., Sebben, S., Cortesi, R., Menegatti, E., Nastruzzi, C., Preparation and characterization of cationic microspheres for gene delivery (1999) Int. J. Pharm., 189, pp. 29-41
Zambaux, E., Faivre-Fiorina, B., Bonneaux, F., Involvement of neutrophilic granulocytes in the uptake of biodegradable non-stealth and stealth nanoparticles in guinea pig (2000) Biomaterials, 21, pp. 975-980
Fernandez-Urrusuno, R., Fattal, E., Rodrigues Jr., J.M., FeH ger, J., Bedossa, P., Couvreur, P., Effect of polymeric nanoparticle administration on the clearance activity of the mononuclear phagocyte system in mice (1996) J. Biomed. Mater. Res., 31, pp. 401-408
Esposito, E., Cortesi, R., Porta, R., Trento, F., Nastruzzi, C., Effect of long-term stabilization of cationic liposomes as defibrotide delivery system for antithrombotic activity (2002) Drug Dev. Res., 5, pp. 127-138
Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles
This article describes the production and characterization of cationic submicron particles constituted with Eudragit RS 100, plus different cationic surfactants, such as dioctadecyl-dimethyl-ammonium bromide (DDAB18) and diisobutyphenoxyethyl-dimethylbenzyl ammonium chloride (DEBDA), as a transport and delivery system for DNA/DNA and DNA/peptide nucleic acid (PNA) hybrids and PNA-DNA chimeras. Submicron particles could offer advantages over other delivery systems because they maintain unaltered physicochemical properties for long time periods, allowing long-term storage, and are suitable for industrial production. Submicron particles were characterized in terms of size, size distribution, morphology, and zeta potential. Moreover, the in vitro activity and ability of submicron particles to complex different types of nucleic acids were described. Finally, the ability of submicron particles to deliver functional genes to cells cultured in vitro was determined by a luciferase activity assay, demonstrating that submicron particles possess superior transfection efficiency with respect to commercially available, liposome-based transfection kits.
This article describes the production and characterization of cationic submicron particles constituted with Eudragit RS 100, plus different cationic surfactants, such as dioctadecyl-dimethyl-ammonium bromide (DDAB18) and diisobutyphenoxyethyl-dimethylbenzyl ammonium chloride (DEBDA), as a transport and delivery system for DNA/DNA and DNA/peptide nucleic acid (PNA) hybrids and PNA-DNA chimeras. Submicron particles could offer advantages over other delivery systems because they maintain unaltered physicochemical properties for long time periods, allowing long-term storage, and are suitable for industrial production. Submicron particles were characterized in terms of size, size distribution, morphology, and zeta potential. Moreover, the in vitro activity and ability of submicron particles to complex different types of nucleic acids were described. Finally, the ability of submicron particles to deliver functional genes to cells cultured in vitro was determined by a luciferase activity assay, demonstrating that submicron particles possess superior transfection efficiency with respect to commercially available, liposome-based transfection kits.
Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles
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Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles
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View Export to BibTeX Export to EndNote
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Impact Factor: 3.679
View Export to BibTeX Export to EndNote
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Impact Factor: 4.122
View Export to BibTeX Export to EndNote
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* Aminocyclodextrin Oligomers as Protective Agents of Protein Aggregation (450 views)
Chempluschem, 2016; 81(7): 660-665.
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View Export to BibTeX Export to EndNote
Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
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Impact Factor: 3.65
View Export to BibTeX Export to EndNote
Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (454 views)
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Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
View Export to BibTeX Export to EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
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Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (445 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
View Export to BibTeX Export to EndNote
Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (431 views)
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Impact Factor: 3.914
View Export to BibTeX Export to EndNote
Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
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Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (381 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (1044 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, Puca A, Pedone C, Scala G, Quinto I, Marasco D
* Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (600 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
Impact Factor: 3.022
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (368 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (391 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (429 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (438 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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22 Records (20 excluding Abstracts).
Total impact factor: 77.622 (70.709 excluding Abstracts).
Total 5 year impact factor: 80.952 (72.44 excluding Abstracts).
Total impact factor: 77.622 (70.709 excluding Abstracts).
Total 5 year impact factor: 80.952 (72.44 excluding Abstracts).
393 views. Last view on Sunday 26 February 2023, 18:58:20
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