Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (635 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
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Paper type: Journal Article, Abstract, Conference,
Impact factor: 1.938, 5-year impact factor: 4.97
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-4143105541&partnerID=40&md5=e88a3510b56cbb8a8db68f0b4e3c6f20
Keywords: Acrylic Acid Resin, Cation, Didodecyldimethylammonium, Drug Carrier, Eudragit Rs, Luciferase, Nucleic Acid, Peptide Nucleic Acid, Quaternary Ammonium Derivative, Surfactant, Adenocarcinoma, Animal, Article, Biosynthesis, Breast Tumor, Cell Culture, Chemistry, Colloid, Drug Stability, Female, Genetic Transfection, Human, Macrophage, Methodology, Mouse, Particle Size, Pathology, Reporter Gene, Tumor Cell Line, Acrylic Resins, Breast Neoplasms, Quaternary Ammonium Compounds, Surface-Active Agents, Delivery, Submicron Particles, Benzethonium Chloride, Cationic Surfactant, Domiphen Bromide, Lipofectamine, Liposome, Polymer, Animal Cell, Cell Growth, Cell Interaction, Cell Proliferation, Cell Strain K 562, Complex Formation, Controlled Study, Cytotoxicity, Drug Delivery System, Drug Formulation, Drug Storage, Drug Synthesis, Drug Transport, Electron Microscopy, Enzyme Activity, Enzyme Assay, Gene Targeting, Human Cell, In Vitro Study, Intermethod Comparison, Nonhuman, Physical Chemistry, Scanning Electron Microscopy, Spray Drying, Zeta Potential,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy.
Dept. of Biochemistry/Molec. Biology, University of Ferrara, Ferrara, Italy
Institute of Biostructure/Bioimaging, CNR, Napoli, France
Lab. Devmt. Pharmacol./Pharmacogen., Biotechnology Centre, University of Ferrara, Ferrara, Italy
Dept. of Pharmaceut. Chem./Technol., University of Perugia, Perugia, Italy
References:
Not available.
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Abstract, Conference,
Impact factor: 1.938, 5-year impact factor: 4.97
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-4143105541&partnerID=40&md5=e88a3510b56cbb8a8db68f0b4e3c6f20
Keywords: Acrylic Acid Resin, Cation, Didodecyldimethylammonium, Drug Carrier, Eudragit Rs, Luciferase, Nucleic Acid, Peptide Nucleic Acid, Quaternary Ammonium Derivative, Surfactant, Adenocarcinoma, Animal, Article, Biosynthesis, Breast Tumor, Cell Culture, Chemistry, Colloid, Drug Stability, Female, Genetic Transfection, Human, Macrophage, Methodology, Mouse, Particle Size, Pathology, Reporter Gene, Tumor Cell Line, Acrylic Resins, Breast Neoplasms, Quaternary Ammonium Compounds, Surface-Active Agents, Delivery, Submicron Particles, Benzethonium Chloride, Cationic Surfactant, Domiphen Bromide, Lipofectamine, Liposome, Polymer, Animal Cell, Cell Growth, Cell Interaction, Cell Proliferation, Cell Strain K 562, Complex Formation, Controlled Study, Cytotoxicity, Drug Delivery System, Drug Formulation, Drug Storage, Drug Synthesis, Drug Transport, Electron Microscopy, Enzyme Activity, Enzyme Assay, Gene Targeting, Human Cell, In Vitro Study, Intermethod Comparison, Nonhuman, Physical Chemistry, Scanning Electron Microscopy, Spray Drying, Zeta Potential,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy.
Dept. of Biochemistry/Molec. Biology, University of Ferrara, Ferrara, Italy
Institute of Biostructure/Bioimaging, CNR, Napoli, France
Lab. Devmt. Pharmacol./Pharmacogen., Biotechnology Centre, University of Ferrara, Ferrara, Italy
Dept. of Pharmaceut. Chem./Technol., University of Perugia, Perugia, Italy
References:
Not available.
Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles
This article describes the production and characterization of cationic submicron particles constituted with Eudragit RS 100, plus different cationic surfactants, such as dioctadecyl-dimethyl-ammonium bromide (DDAB18) and diisobutyphenoxyethyl-dimethylbenzyl ammonium chloride (DEBDA), as a transport and delivery system for DNA/DNA and DNA/peptide nucleic acid (PNA) hybrids and PNA-DNA chimeras. Submicron particles could offer advantages over other delivery systems because they maintain unaltered physicochemical properties for long time periods, allowing long-term storage, and are suitable for industrial production. Submicron particles were characterized in terms of size, size distribution, morphology, and zeta potential. Moreover, the in vitro activity and ability of submicron particles to complex different types of nucleic acids were described. Finally, the ability of submicron particles to deliver functional genes to cells cultured in vitro was determined by a luciferase activity assay, demonstrating that submicron particles possess superior transfection efficiency with respect to commercially available, liposome-based transfection kits.
This article describes the production and characterization of cationic submicron particles constituted with Eudragit RS 100, plus different cationic surfactants, such as dioctadecyl-dimethyl-ammonium bromide (DDAB18) and diisobutyphenoxyethyl-dimethylbenzyl ammonium chloride (DEBDA), as a transport and delivery system for DNA/DNA and DNA/peptide nucleic acid (PNA) hybrids and PNA-DNA chimeras. Submicron particles could offer advantages over other delivery systems because they maintain unaltered physicochemical properties for long time periods, allowing long-term storage, and are suitable for industrial production. Submicron particles were characterized in terms of size, size distribution, morphology, and zeta potential. Moreover, the in vitro activity and ability of submicron particles to complex different types of nucleic acids were described. Finally, the ability of submicron particles to deliver functional genes to cells cultured in vitro was determined by a luciferase activity assay, demonstrating that submicron particles possess superior transfection efficiency with respect to commercially available, liposome-based transfection kits.
Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles
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Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 1.546
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 4.195
View Export to BibTeX Export to EndNote
Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
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Impact Factor: 3.914
View Export to BibTeX Export to EndNote
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Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (708 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
View Export to BibTeX Export to EndNote
Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (1558 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
View Export to BibTeX Export to EndNote
Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, Puca A, Pedone C, Scala G, Quinto I, Marasco D
* Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (865 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
Impact Factor: 3.022
View Export to BibTeX Export to EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (804 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
View Export to BibTeX Export to EndNote
Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
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Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (567 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (726 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (772 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
View Export to BibTeX Export to EndNote
Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (838 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
View Export to BibTeX Export to EndNote
22 Records (20 excluding Abstracts).
Total impact factor: 77.622 (70.709 excluding Abstracts).
Total 5 year impact factor: 80.952 (72.44 excluding Abstracts).
Total impact factor: 77.622 (70.709 excluding Abstracts).
Total 5 year impact factor: 80.952 (72.44 excluding Abstracts).
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