Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging?(334 views) Mainenti PP, Iodice D, Segreto S, Storto G, Magliulo M, De Palma GD, Salvatore M, Pace L
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2011 Mar 21; 17(11): 1427-1433.
Keywords: Cancer, Colorectal, Positron Emission Tomography Computed Tomography, Staging, Fluorodeoxyglucose F 18, Adenocarcinoma, Article, Cancer Diagnosis, Cancer Staging, Clinical Article, Colorectal Cancer, Computer Assisted Tomography, Diagnostic Accuracy, Human, Adult, 80 And Over, Chi-Square Distribution, Colorectal Neoplasms, Female, Logistic Models, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Positron-Emission Tomography, Predictive Value Of Tests, Radiopharmaceuticals, X-Ray Computed,
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini Consiglio Nazionale delle Ricerche, Naples 80131, Italy. pierpamainenti@hotmail.com
Department of Biomorphological and Functional Sciences, University of Naples 'Federico II', Naples 80131, Italy
Istitituto di Ricovero e Cura a carattere scientifico, Centro di Riferimento Oncologico della Basilicata, Vulture 85028 PZ, Italy
Department of General Surgery, Geriatry and Endoscopy, University of Naples 'Federico II', Naples 80131, Italy
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Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging?
AIM: To evaluate whether FDG-positron emission tomography (PET)/computed tomography (CT) may be an accurate technique in the assessment of the T stage in patients with colorectal cancer.; METHODS: Thirty four consecutive patients (20 men and 14 women; mean age: 63 years) with a histologically proven diagnosis of colorectal adenocarcinoma and scheduled for surgery in our hospital were enrolled in this study. All patients underwent FDG-PET/CT preoperatively. The primary tumor site and extent were evaluated on PET/CT images. Colorectal wall invasion was analysed according to a modified T classification that considers only three stages (≤ T2, T3, T4). Assessment of accuracy was carried out using 95% confidence intervals for T.; RESULTS: Thirty five/37 (94.6%) adenocarcinomas were identified and correctly located on PET/CT images. PET/CT correctly staged the T of 33/35 lesions identified showing an accuracy of 94.3% (95% CI: 87%-100%). All T1, T3 and T4 lesions were correctly staged, while two T2 neoplasms were overstated as T3.; CONCLUSION: Our data suggest that FDG-PET/CT may be an accurate modality for identifying primary tumor and defining its local extent in patients with colorectal cancer.
Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging?
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Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging?