Isothermal amplification methods for the detection of nucleic acids in microfluidic devices (480 views)
Biosensors (ISSN: 2079-6374), 2013 Mar; 3(1): 18-43.
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Keywords: Dna, Isothermal Amplification Methods, Microfluidics, Miniaturization, Nucleic Acid, Automation, Dna Determination, Helicase Dependent Amplification, High Throughput Screening, Loop Mediated Isothermal Amplification, Multiple Displacement Amplification, Nucleic Acid Amplification, Nucleic Acid Sequence Based Amplification, Nucleotide Sequence, Polymerase Chain Reaction, Recombinase Polymerase Amplification, Review, Rolling Circle Amplification, Sensitivity Analysis, Temperature Dependence,
Affiliations:
*** IBB - CNR ***
Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, Catania, Italy
Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, I-95125 Catania, Italy
References:
D'Agata, R., Breveglieri, G., Zanoli, L.M., Borgatti, M., Spoto, G., Gambari, R., Direct detection of point mutations in nonamplified human genomic DNA (2011) Anal. Chem., 83, pp. 8711-871
Marchelli, R., Tedeschi, T., Tonelli, A., DNA analyses in food safety and quality: Current status and expectations (2012) Detection of Non-Amplified Genomic DNA
Spoto, G., Corradini, R., Eds., pp. 25-63. , Springer: Dordrecht, The Netherland
D'Agata, R., Corradini, R., Ferretti, C., Zanoli, L., Gatti, M., Marchelli, R., Spoto, G., Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced Surface-Plasmon Resonance Imaging (2010) Biosens. Bioelectron., 25, pp. 2095-2100
Shi, L., Perkins, R.G., Fang, H., Tong, W., Reproducible and reliable microarray results through quality control: Good laboratory proficiency and appropriate data analysis practices are essential (2008) Curr. Opin. Biotechnol., 19, pp. 10-18
Spoto, G., Minunni, M., Surface Plasmon Resonance imaging: What's next? (2012) J. Phys. Chem. Lett., 3, pp. 2682-2691
Zanoli, L.M., D'Agata, R., Spoto, G., Functionalized gold nanoparticles for the ultrasensitive DNA detection (2012) Anal. Bioanal. Chem., 402, pp. 1759-1771
Asiello, P.J., Baeumner, A.J., Miniaturized isothermal nucleic acid amplification, a review (2011) Lab Chip, 11, pp. 1420-1430
Leng, X., Zhang, W., Wang, C., Cui, L., Yang, C.J., Agarose droplet microfluidics for highly parallel and efficient single molecule emulsion PCR (2010) Lab Chip, 10, pp. 2841-2843
Kojima, T., Takei, Y., Ohtsuka, M., Kawarasaki, Y., Yamane, T., Nakano, H., PCR amplification from single DNA molecules on magnetic beads in emulsion: application for high-throughput screening of transcription factor targets (2005) Nucleic Acids Res., p. 33. , doi: 101093/nar/gni143
Kim, J., Easley, C.J., Isothermal DNA amplification in bioanalysis: Strategies and applications (2011) Bioanalysis, 3, pp. 227-239
Whitesides, G.M., The origins and future of microfluidics (2006) Nature, 422, pp. 368-373
Beebe, D.J., Mensing, G.A., Walker, G.M., Physics and applications of microfluidics in biology (2002) Annu. Rev. Biomed. Eng., 4, pp. 261-286
Stone, H.A., Stroock, A.D., Ajdari, A., Engineering flows in small devices: Microfluidics toward a lab-on-a-chip (2004) Annu. Rev. Fluid Mech., 36, pp. 381-411
Squires, T.M., Quake, S.R., Microfluidics: Fluid physics at the nanoliter scale (2005) Rev. Mod. Phys., 77, pp. 977-1026
Buchegger, W., Haller, A., van den Driesche, S., Kraft, M., Lendl, B., Vellekoop, M., Studying enzymatic bioreactions in a millisecond microfluidic flow mixer (2012) Biomicrofluidics, 6, pp. 12803-128039
Buchegger, W., Wagner, C., Lendl, B., Kraft, M., Vellekoop, M., A highly uniform lamination micromixer with wedge shaped inlet channels for time resolved infrared spectroscopy (2011) Microfluid. Nanofluid., 10, pp. 889-897
Lee, C.-Y., Chang, C.-L., Wang, Y.-N., Fu, L.-M., Microfluidic mixing: A review (2011) Int. J. Mol. Sci., 12, pp. 3263-3287
Hartwell, S.K., Grudpan, K., Flow-based systems for rapid and high-precision enzyme kinetics studies (2012) J. Anal. Methods Chem., , doi: 10.1155/2012/450716
Bleul, R., Ritzi-Lehnert, M., Höth, J., Scharpfenecker, N., Frese, I., Düchs, D., Brunklaus, S., Drese, K.S., Compact, cost-efficient microfluidics-based stopped-flow device (2011) Anal. Bioanal. Chem., 399, pp. 1117-1125
Zhang, Y., Ozdemir, P., Microfluidic DNA amplification-A review (2009) Anal. Chim. Acta., 638, pp. 115-125
Shaw, K.J., Docker, P.T., Yelland, J.V., Dyer, C.E., Greenman, J., Greenwaya, G.M., Haswell, S.J., Rapid PCR amplification using a microfluidic device with integrated microwave heating and air impingement cooling (2010) Lab Chip, 10, pp. 1725-1728
Li, Y., Zhang, C., Xing, D., Integrated microfluidic reverse transcription-polymerase chain reaction for rapid detection of food-or waterborne pathogenic rotavirus (2011) Anal. Biochem., 415, pp. 87-96
Zhang, H., Jenkins, G., Zou, Y., Zhu, Z., Yang, C.J., Massively parallel single-molecule and single-cell emulsion reverse transcription polymerase chain reaction using Agarose droplet microfluidics (2012) Anal. Chem., 84, pp. 3599-3606
Luna-Vera, F., Alvarez, J.C., Adsorption kinetics of proteins in plastic microfluidic channels: Real-time monitoring of lysozyme adsorption by pulsed streaming potentials Biosens (2010) Bioelectron., 25, pp. 1539-1543
Christensen, T.B., Pedersen, C.M., Gröndahl, K.G., Jensen, T.G., Sekulovic, A., Bang, D.D., Wolff, A., PCR biocompatibility of lab-on-a-chip and MEMS materials (2007) J. Micromech. Microeng., 17, pp. 1527-1532
Erill, I., Campoy, S., Erill, N., Barbe, J., Aguilo, J., Biochemical analysis and optimization of inhibition and adsorption phenomena in glass-silicon PCR-chips (2003) Sens. Actuator. B, 96, pp. 685-692
Kricka, L.J., Wilding, P., Microchip PCR (2003) Anal. Bioanal. Chem., 377, pp. 820-825
Felbel, J., Bieber, I., Pipper, J., Kohler, J.M., Investigations on the compatibility of chemically oxidized silicon (SiOx)-surfaces for applications towards chip-based polymerase chain reaction (2004) Chem. Eng. J., 101, pp. 333-338
Panaro, N.J., Lou, X.J., Fortina, P., Kricka, L.J., Wilding, P., Surface effects on PCR reactions in multichip microfluidic platforms (2004) Biomed. Microdevices, 6, pp. 75-80
Zanoli, L.M., Licciardello, M., D'Agata, R., Lantano, C., Calabretta, A., Corradini, R., Marchelli, R., Spoto, G., Peptide nucleic acid molecular beacons for the detection of PCR amplicons in droplet-based microfluidic devices (2012) Anal. Bioanal. Chem., , doi: 10.1007/s00216-011-5638-3
Christopher, G.F., Anna, S.L., Microfluidic methods for generating continuous droplet streams (2007) J. Phys. D Appl. Phys., 40, pp. R319-R336
Griffiths, A.D., Tawfik, D.S., Miniaturising the laboratory in emulsion droplets (2006) Trends Biotechnol., 24, pp. 395-402
Fair, R.B., Digital microfluidics: Is a true lab-on-a-chip possible? (2007) Microfluid. Nanofluid., 3, pp. 245-281
Zeng, Y., Novak, R., Shuga, J., Smith, M.T., Mathies, R.A., High-performance single cell genetic analysis using microfluidic emulsion generator arrays (2010) Anal. Chem., 82, pp. 3183-3190
Kiss, M.M., Ortoleva-Donnelly, L., Beer, N.R., Warner, J., Bailey, C.G., Colston, B.W., Rothberg, J.M., Leamon, J.H., High-throughput quantitative polymerase chain reaction in picoliter droplets (2008) Anal. Chem., 80, pp. 8975-8981
Hua, Z., Rouse, J.L., Eckhardt, A.E., Srinivasan, V., Pamula, V.K., Schell, W.A., Benton, J.L., Pollack, M.G., Multiplexed real-time polymerase chain reaction on a digital microfluidic platform (2010) Anal. Chem., 82, pp. 2310-2316
Zhu, Z., Jenkins, G., Zhang, W., Zhang, M., Guan, Z., Yang, C.J., Single-molecule emulsion PCR in microfluidic droplets (2012) Anal. Bioanal. Chem., 403, pp. 2127-2143
Notomi, T., Okayama, H., Masubuchi, H., Yonekawa, T., Watanabe, K., Amino, N., Hase, T., Loop-mediated isothermal amplification of DNA (2000) Nucleic Acids Res., p. 28. , doi: 101093/nar/28.12.e63
Curtis, K.A., Rudolph, D.L., Owen, S.M., Rapid detection of HIV-1 by reverse-transcription, loop-mediated isothermal amplification (RT-LAMP) (2008) J. Virol. Methods, 151, pp. 264-270
Hong, T.C., Mai, Q.L., Cuong, D.V., Development and evaluation of a novel loop-mediated isothermal amplification method for rapid detection of severe acute respiratory syndrome coronavirus (2004) J. Clin. Microbiol., 42, pp. 1956-1961
Misawa, Y., Yoshida, A., Saito, R., Yoshida, H., Okuzumi, K., Ito, N., Okada, M., Koike, K., Application of loop-mediated isothermal amplifi cation technique to rapid and direct detection of methicillin-resistant Staphylococcus aureus (MRSA) in blood cultures (2007) J. Infect. Chemother., 13, pp. 134-140
Ohtsuka, K., Yanagawa, K., Takatori, K., Hara-Kudo, Y., Detection of Salmonella enterica in naturally contaminated liquid eggs by loop-mediated isothermal amplification, and characterization of salmonella isolates (2005) Appl. Environ. Microbiol., 71, pp. 6730-6735
Liu, C., Mauk, M.G., Bau, H.H., A disposable, integrated loop-mediated isothermal amplification cassette with thermally actuated valves (2011) Microfluid. Nanofluid., 11, pp. 209-220
Yoshida, A., Nagashima, S., Ansai, T., Tachibana, M., Kato, H., Watari, H., Notomi, T., Takehara, T., Loop-mediated isothermal amplification method for rapid detection of the periodontopathic bacteria Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola (2005) J. Clin. Microbiol., 43, pp. 2418-2424
Mori, Y., Nagamine, K., Tomita, N., Notomi, T., Detection of loop-mediated isothermal amplification reaction by turbidity derived from magnesium pyrophosphate formation (2001) Biochem. Biophys. Res. Commun., 289, pp. 150-154
Nakamura, N., Fukuda, T., Nonen, S., Hashimoto, K., Azuma, J., Gemma, N., Simple and accurate determination of CYP2D6 gene copy number by a loop-mediated isothermal amplification method and an electrochemical DNA chip Clin (2010) Chim. Acta., 411, pp. 568-573
Iwamoto, T., Sonobe, T., Hayashi, K., Loop-mediated isothermal amplification for direct detection of mycobacterium tuberculosis complex, M. avium, and M. intracellulare in sputum samples (2003) J. Clin. Microbiol., 41, pp. 2616-2622
Lee, S.Y., Huang, J.G., Chuang, T.L., Sheu, J.C., Chuang, Y.K., Holl, M., Meldrum, D.R., Lin, C.W., Compact optical diagnostic device for isothermal nucleic acids amplification (2008) Sens. Actuator. B, 133, pp. 493-501
Lee, S.Y., Lee, C.N., Holl, M., Meldrum, D.R., Lin, C.W., Efficient, specific, compact hepatitis B diagnostic device: Optical detection of the hepatitis B virus by isothermal amplification (2007) Sens. Actuator. B, 127, pp. 598-605
Hataoka, Y., Zhang, L.H., Mori, Y., Tomita, N., Notomi, T., Baba, Y., Analysis of specific gene by integration of isothermal amplification and electrophoresis on poly(methyl methacrylate) microchips (2004) Anal. Chem., 76, pp. 3689-3693
Fang, X., Liu, Y., Kong, J., Jiang, X., Loop-mediated isothermal amplification integrated on microfluidic chips for point-of-care quantitative detection of pathogens (2010) Anal. Chem., 82, pp. 3002-3006
Lam, L., Sakakihara, S., Ishizuka, K., Takeuchi, S., Arata, H.F., Fujita, H., Noji, H., Loop-mediated isothermal amplification of a single DNA molecule in polyacrylamide gel-based microchamber (2008) Biomed. Microdevices, 10, pp. 539-546
Safavieh, M., Ahmed, M.U., Tolba, M., Zourob, M., Microfluidic electrochemical assay for rapid detection and quantification of Escherichia coli (2012) Biosens. Bioelectron., 31, pp. 523-528
Nakamura, N., Ito, K., Takahashi, M., Hashimoto, K., Kawamoto, M., Yamanaka, M., Taniguchi, A., Gemma, N., Detection of six single-nucleotide polymorphisms associated with rheumatoid arthritis by a loop-mediated isothermal amplification method and an electrochemical DNA chip (2007) Anal. Chem., 79, pp. 9484-9493
Lee, T.M., Over-the-counter biosensors: Past, present, and future (2008) Sensors, 8, pp. 5535-5559
Abdel-Monem, M., Hoffmann-Berling, H., Enzymic unwinding of DNA 1: Purification and characterization of a DNA-dependent ATPase (1976) Escherichia coli. Eur. J. Biochem., 65, pp. 431-440
Abdel-Monem, M., Durwald, H., Hoffmann-Berling, H., Enzymic unwinding of DNA. 2. Chain separation by an ATP-dependent DNA unwinding enzyme. (1976) Eur. J. Biochem., 65, pp. 441-449
Vincent, M., Xu, Y., Kong, H., Helicase-dependent isothermal DNA amplification (2004) EMBO Rep., 5, pp. 795-800
Jeong, Y.-J., Park, K., Kim, D.-E., Isothermal DNA amplification in vitro: The helicase-dependent amplification system (2009) Cell. Mol. Life Sci., 66, pp. 3325-3336
Tuteja, N., Tuteja, R., Unraveling DNA helicases. Motif, structure, mechanism and function (2004) Eur. J. Biochem., 271, pp. 1849-1863
Jankowsky, E., RNA helicases at work: Binding and rearranging (2011) Trends Biochem. Sci., 36, pp. 19-29
Pyle, A.M., Translocation and unwinding mechanisms of RNA and DNA helicases (2008) Annu. Rev. Biophys., 37, pp. 317-336
Hall, M.C., Matson, S.W., Helicase motifs: The engine that powers DNA unwinding (1999) Mol. Microbiol., 34, pp. 867-877
Runyon, G.T., Lohman, T.M., Escherichia coli helicase II (uvrD) protein can completely unwind fully duplex linear and nicked circular DNA (1989) J. Biol. Chem., 264, pp. 17502-17512
Furukohri, A., Nishikawa, Y., Akiyama, M.T., Maki, H., Interaction between Escherichia coli DNA polymerase IV and single-stranded DNA-binding protein is required for DNA synthesis on SSB-coated DNA (2012) Nucleic Acids Res., 40, pp. 6039-6048
Shereda, R.D., Kozlov, A.G., Lohman, T.M., Cox, M.M., Keck, J.L., SSB as an organizer/mobilizer of genome maintenance complexes (2008) Crit. Rev. Biochem. Mol. Biol., 43, pp. 289-318
Mechanic, L.E., Frankel, B.A., Matson, S.W., Escherichia coli MutL loads DNA helicase II onto DNA (2000) J. Biol. Chem., 275, pp. 38337-38346
Matson, S.W., Robertson, A.B., The UvrD helicase and its modulation by the mismatch repair protein MutL (2006) Nucleic Acids Res., 34, pp. 4089-4097
An, L., Tang, W., Ranalli, T.A., Kim, H.J., Wytiaz, J., Kong, H., Characterization of a thermostable UvrD helicase and its participation in helicase-dependent amplification (2005) J. Biol. Chem., 280, pp. 28952-28958
Goldmeyer, J., Kong, H., Tang, W., Development of a novel one-tube isothermal reverse transcription thermophilic helicase-dependent amplification platform for rapid RNA detection (2007) J. Mol. Diagn., 9, pp. 639-644
Tong, Y., Tang, W., Kim, H.J., Pan, X., Ranalli, T., Kong, H., Development of isothermal TaqMan assays for detection of biothreat organisms (2008) Biotechniques, 45, pp. 543-557
Andresen, D., von Nickisch-Rosenegk, M., Bier, F.F., Helicase dependent on chip-amplification and its use in multiplex pathogen detection (2009) Clin. Chim. Acta., 403, pp. 244-248
http://www.biohelix.com/, IsoAmp II tHDA Kit
Biohelix Corporation: Beverly, MA, USA. Available online, (accessed on 7 November 2012)Ramalingam, N., San, T.C., Kai, T.J., Mak, M.Y.M., Gong, H.-Q., Microfluidic devices harboring unsealed reactors for real-time isothermal helicase-dependent amplification (2009) Microfluid. Nanofluid., 7, pp. 325-336
Tong, Y., Lemieux, B., Kong, H., Multiple strategies to improve sensitivity, speed and robustness of isothermal nucleic acid amplification for rapid pathogen detection (2011) BMC Biotechnol., p. 11. , doi: 101186/1472-6750-11-50
Mahalanabis, M., Do, J., AlMuayad, H., Zhang, J.Y., Klapperich, C.M., An integrated disposable device for DNA extraction and helicase dependent amplification (2010) Biomed. Microdevices, 12, pp. 353-359
Baner, J., Nilsson, M., Mendel-Hartvig, M., Landergren, U., Signal amplification of padlock probes by rolling circle replication (1998) Nucl. Acids Res., 26, pp. 5073-5078
Mothershed, E.A., Whitney, A.M., Nucleic acid-based methods for the detection of bacterial pathogens: Present and future considerations for the clinical laboratory (2006) Clin. Chim. Acta., 363, pp. 206-220
Nilsson, M., Malmgren, H., Samiotaki, M., Kwiatkowski, M., Chowdhary, B.P., Landegren, U., Padlock probes: Circularizing oligonucleotides for localized DNA detection (1994) Science, 265, pp. 2085-2088
Lizardi, P.M., Huang, X.H., Zhu, Z.R., Bray-Ward, P., Thomas, D.C., Ward, D.C., Mutation detection and single-molecule counting using isothermal rolling-circle amplification (1998) Nat. Genet., 19, pp. 225-232
Jarvius, J., Melin, J., Göransson, J., Stenberg, J., Fredriksson, S., Gonzalez-Rey, C., Bertilsson, S., Nilsson, M., Digital quantification using amplified single-molecule detection (2006) Nat. Mater., 3, pp. 725-727
Melin, J., Jarvius, J., Gransson, J., Nilsson, M., Homogeneous amplified single-molecule detection: Characterization of key parameters (2007) Anal. Biochem., 368, pp. 230-238
Johne, R., Mueller, H., Rector, A., van Ranst, M., Stevens, H., Rolling-circle amplification of viral DNA genomes using phi29 polymerase (2009) Trends Microbiol., 17, pp. 205-211
Hutchison, C.A., Smith, H.O., Pfannkoch, C., Venter, J.C., Cell-free cloning using phi29 DNA polymerase (2005) Proc. Natl. Acad. Sci., 102, pp. 17332-17336
Mahmoudian, L., Kaji, N., Tokeshi, M., Nilsson, M., Baba, Y., Rolling circle amplification and circle-to-circle amplification of a specific gene integrated with electrophoretic analysis on a single chip (2008) Anal. Chem., 80, pp. 2483-2490
Dahl, F., Baner, J., Gullberg, M., Mendel-Hartvig, M., Landegren, U., Nilsson, M., Circle-to-circle amplification for precise and sensitive DNA analysis (2004) Proc. Natl. Acad. Sci. USA, 101, pp. 4548-4553
Mahmoudian, L., Melin, J., Mohamadi, M.R., Yamada, K., Ohta, M., Kaji, N., Tokeshi, M., Baba, Y., Microchip electrophoresis for specific gene detection of the pathogenic bacteria V (2008) cholerae by circle-to-circle amplification. Anal. Sci., 24, pp. 327-332
Mazutis, L., Araghi, A.F., Miller, O.J., Baret, J.C., Frenz, L., Janoshazi, A., Taly, V., Ryckelynck, M., Droplet-based microfluidic systems for high-throughput single dna molecule isothermal amplification and analysis (2009) Anal. Chem., 81, pp. 4813-4821
Juul, S., Nielsen, C.J., Labouriau, R., Roy, A., Tesauro, C., Jensen, P.W., Harmsen, C., Knudsen, B.R., Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing plasmodium parasites based on enzyme activity measurement (2012) ACS Nano, , doi: 10.1021/nn3038594
Dean, F.B., Hosono, S., Fang, L., Wu, X., Faruqi, A.F., Bray-Ward, P., Sun, Z., Lasken, R.S., Comprehensive human genome amplification using multiple displacement amplification (2002) Proc. Natl. Acad. Sci., 99, pp. 5261-5266
Blanco, L., Bernad, A., Lazaro, J.M., Martin, G., Garmendia, C., Salas, M., Highly efficient DNA synthesis by the phage phi 29 DNA polymerase, Symmetrical mode of DNA replication. (1989) J. Biol. Chem., 264, pp. 8935-8940
Nelson, J.R., Cai, Y.C., Giesler, T.L., Farchaus, J.W., Sundaram, S.T., Ortiz-Rivera, M., Hosta, L.P., Fuller, C.W., TempliPhi, phi29 DNA polymerase based rolling circle amplification of templates for DNA sequencing (2002) Biotechniques, 32, pp. S44-S47
Ling, L.L., Keohavong, P., Dias, C., Thilly, W.G., Optimization of the polymerase chain reaction with regard to fidelity: Modified T7, Taq, and vent DNA polymerases (1991) Genome Res., 1, pp. 63-69
Keohavong, P., Thilly, W.G., Fidelity of DNA polymerases in DNA amplification (1989) Proc. Natl. Acad. Sci., 86, pp. 9253-9257
Hosono, S., Faruqi, A.F., Dean, F.B., Du, Y., Sun, Z., Wu, X., Du, J., Lasken, R.S., Unbiased whole genome amplification directly from clinical samples (2003) Genome Res., 13, pp. 954-964
Raghunathan, A., Ferguson Jr., H.R., Bornarth, C.J., Song, W., Driscoll, M., Lasken, R.S., Genomic DNA amplification from a single bacterium (2005) Appl. Environ. Microbiol., 71, pp. 3342-3347
Marcy, Y., Ishoey, T., Lasken, R.S., Stockwell, T.B., Walenz, B.P., Halpern, A.L., Beeson, K.Y., Quake, S.R., Nanoliter reactors improve multiple displacement amplification of genomes from single cells (2007) PloS Genet., p. 3. , doi: 101371/journal.pgen.0030155
Piepenburg, O., Williams, C.H., Stemple, D.L., Armes, N.A., DNA detection using recombination proteins (2006) PloS Biol., p. 4. , doi: 101371/journal.pbio.0040204
Lutz, S., Weber, P., Focke, M., Faltin, B., Hoffmann, J., Müller, C., Mark, D., von Stetten, F., Microfluidic lab-on-a-foil for nucleic acid analysis based on isothermal recombinase polymerase amplification (RPA) (2010) Lab Chip, 10, pp. 887-893
Hakenberg, S., Hügle, M., Weidmann, M., Hufert, F., Dame, G., Urban, G.A., A phaseguided passive batch microfluidic mixing chamber for isothermal amplification (2012) Lab Chip, 12, pp. 4576-4580
Vulto, P., Podszun, S., Meyer, P., Hermann, C., Manz, A., Urban, G.A., Phaseguides: A paradigm shift in microfluidic priming and emptying (2011) Lab Chip, 11, pp. 1596-1602
Paul, N., Shum, J., Le, T., Hot start PCR (2010) Methods Mol. Biol., 630, pp. 301-318
Shen, F., Davydova, E.K., Du, W., Kreutz, J.E., Piepenburg, O., Ismagilov, R.F., Digital isothermal quantification of nucleic acids via simultaneous chemical initiation of recombinase polymerase amplification reactions on SlipChip (2011) Anal. Chem., 83, pp. 3533-3540
Compton, J., Nucleic acid sequence-based amplification (1991) Nature, 350, pp. 91-92
Deiman, B., van Aarle, P., Sillekens, P., Characteristics and applications of nucleic acid sequence-based amplification (NASBA) (2002) Mol. Biotechnol., 20, pp. 163-179
Yates, S., Penning, M., Goudsmit, J., Frantzen, I., van de Weijer, B., van Strijp, D., van Gemen, B., Quantitative detection of hepatitis B virus DNA by real-time nucleic acid sequence-based amplification with molecular beacon detection (2001) J. Clin. Microbiol., 39, pp. 3656-3665
van Gemen, B., van Beuningen, R., Nabbe, A., van Strijp, D., Jurriaans, S., Lens, P., Kievits, T., A one-tube quantitative HIV-1 RNA NASBA nucleic acid amplification assay using electrochemiluminiscent (ECL) labelled probes (1994) J. Virol. Methods, 49, pp. 157-168
Shan, S., Ko, L.S., Collins, R.A., Wu, Z., Chen, J., Chan, K.Y., Xing, J., Yu, A.C., Comparison of nucleic acid-based detection of avian influenza H5N1 with virus isolation (2003) Biochem. Biophys. Res. Commun., 302, pp. 377-383
Connelly, J.T., Nugen, S.R., Borejsza-Wysocki, W., Durst, R.A., Montagna, R.A., Baeumner, A.J., Human pathogenic Cryptosporidium species bioanalytical detection method with single oocyst detection capability (2008) Anal. Bioanal. Chem., 391, pp. 487-495
Nugen, S.R., Asiello, P.J., Connelly, J.T., Baeumner, A.J., PMMA biosensor for nucleic acids with integrated mixer and electrochemical detection (2009) Biosens. Bioelectron., 24, pp. 2428-2433
Wang, Y., Li, J., Jin, J., Wang, H., Tang, H., Yang, R., Wang, K., Strategy for molecular beacon binding readout: Separating molecular recognition element and signal reporter (2009) Anal. Chem., 81, pp. 9703-9709
Wang, K., Tang, Z., Yang, C.J., Kim, Y., Fang, X., Li, W., Wu, Y., Tan, W., Molecular engineering of DNA: Molecular beacons (2009) Angew. Chem. Int. Edit., 48, pp. 856-870
Gore, H.M., Wakeman, C.A., Hull, R.M., McKillip, J.L., Real-time molecular beacon NASBA reveals hblc expression from Bacillus spp (2003) in milk. Biochem. Biophys. Res. Commun., 311, pp. 386-390
Nadal, A., Coll, A., Cook, N., Pla, M., A molecular beacon-based real time NASBA assay for detection of Listeria monocytogenes in food products: Role of target mRNA secondary structure on NASBA design (2007) J. Microbiol. Methods, 68, pp. 623-632
Gulliksen, A., Solli, L., Karlsen, F., Rogne, H., Hovig, E., Nordstrom, T., Sirevag, R., Real-time nucleic acid sequence-based amplification in nanoliter volumes (2004) Anal. Chem., 76, pp. 9-14
Gulliksen, A., Keegan, H., Martin, C., O'Leary, J., Solli, L.A., Falang, I.M., Grønn, P., Furuberg, L., Towards a "sample-in, answer-out" point-of-care platformfor nucleic acid extraction and amplification: Using an HPV E6/E7mRNAModel System (2012) J. Oncol., , doi:10.1155/2012/905024
Dimov, I.K., Garcia-Cordero, J.L., O'Grady, J., Poulsen, C.R., Viguier, C., Kent, L., Daly, P., Lee, L.P., Integrated microfluidic tmRNA purification and real-time NASBA device for molecular diagnostics (2008) Lab Chip, 8, pp. 2071-2078
Zhao, X., Dong, T., Yang, Z., Pires, N., Hoivik, N., Compatible immuno-NASBA LOC device for quantitative detection of waterborne pathogens: Design and validation (2012) Lab Chip, 12, pp. 602-612
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Keywords: Dna, Isothermal Amplification Methods, Microfluidics, Miniaturization, Nucleic Acid, Automation, Dna Determination, Helicase Dependent Amplification, High Throughput Screening, Loop Mediated Isothermal Amplification, Multiple Displacement Amplification, Nucleic Acid Amplification, Nucleic Acid Sequence Based Amplification, Nucleotide Sequence, Polymerase Chain Reaction, Recombinase Polymerase Amplification, Review, Rolling Circle Amplification, Sensitivity Analysis, Temperature Dependence,
Affiliations:
*** IBB - CNR ***
Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, Catania, Italy
Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, I-95125 Catania, Italy
References:
D'Agata, R., Breveglieri, G., Zanoli, L.M., Borgatti, M., Spoto, G., Gambari, R., Direct detection of point mutations in nonamplified human genomic DNA (2011) Anal. Chem., 83, pp. 8711-871
Marchelli, R., Tedeschi, T., Tonelli, A., DNA analyses in food safety and quality: Current status and expectations (2012) Detection of Non-Amplified Genomic DNA
Spoto, G., Corradini, R., Eds., pp. 25-63. , Springer: Dordrecht, The Netherland
D'Agata, R., Corradini, R., Ferretti, C., Zanoli, L., Gatti, M., Marchelli, R., Spoto, G., Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced Surface-Plasmon Resonance Imaging (2010) Biosens. Bioelectron., 25, pp. 2095-2100
Shi, L., Perkins, R.G., Fang, H., Tong, W., Reproducible and reliable microarray results through quality control: Good laboratory proficiency and appropriate data analysis practices are essential (2008) Curr. Opin. Biotechnol., 19, pp. 10-18
Spoto, G., Minunni, M., Surface Plasmon Resonance imaging: What's next? (2012) J. Phys. Chem. Lett., 3, pp. 2682-2691
Zanoli, L.M., D'Agata, R., Spoto, G., Functionalized gold nanoparticles for the ultrasensitive DNA detection (2012) Anal. Bioanal. Chem., 402, pp. 1759-1771
Asiello, P.J., Baeumner, A.J., Miniaturized isothermal nucleic acid amplification, a review (2011) Lab Chip, 11, pp. 1420-1430
Leng, X., Zhang, W., Wang, C., Cui, L., Yang, C.J., Agarose droplet microfluidics for highly parallel and efficient single molecule emulsion PCR (2010) Lab Chip, 10, pp. 2841-2843
Kojima, T., Takei, Y., Ohtsuka, M., Kawarasaki, Y., Yamane, T., Nakano, H., PCR amplification from single DNA molecules on magnetic beads in emulsion: application for high-throughput screening of transcription factor targets (2005) Nucleic Acids Res., p. 33. , doi: 101093/nar/gni143
Kim, J., Easley, C.J., Isothermal DNA amplification in bioanalysis: Strategies and applications (2011) Bioanalysis, 3, pp. 227-239
Whitesides, G.M., The origins and future of microfluidics (2006) Nature, 422, pp. 368-373
Beebe, D.J., Mensing, G.A., Walker, G.M., Physics and applications of microfluidics in biology (2002) Annu. Rev. Biomed. Eng., 4, pp. 261-286
Stone, H.A., Stroock, A.D., Ajdari, A., Engineering flows in small devices: Microfluidics toward a lab-on-a-chip (2004) Annu. Rev. Fluid Mech., 36, pp. 381-411
Squires, T.M., Quake, S.R., Microfluidics: Fluid physics at the nanoliter scale (2005) Rev. Mod. Phys., 77, pp. 977-1026
Buchegger, W., Haller, A., van den Driesche, S., Kraft, M., Lendl, B., Vellekoop, M., Studying enzymatic bioreactions in a millisecond microfluidic flow mixer (2012) Biomicrofluidics, 6, pp. 12803-128039
Buchegger, W., Wagner, C., Lendl, B., Kraft, M., Vellekoop, M., A highly uniform lamination micromixer with wedge shaped inlet channels for time resolved infrared spectroscopy (2011) Microfluid. Nanofluid., 10, pp. 889-897
Lee, C.-Y., Chang, C.-L., Wang, Y.-N., Fu, L.-M., Microfluidic mixing: A review (2011) Int. J. Mol. Sci., 12, pp. 3263-3287
Hartwell, S.K., Grudpan, K., Flow-based systems for rapid and high-precision enzyme kinetics studies (2012) J. Anal. Methods Chem., , doi: 10.1155/2012/450716
Bleul, R., Ritzi-Lehnert, M., Höth, J., Scharpfenecker, N., Frese, I., Düchs, D., Brunklaus, S., Drese, K.S., Compact, cost-efficient microfluidics-based stopped-flow device (2011) Anal. Bioanal. Chem., 399, pp. 1117-1125
Zhang, Y., Ozdemir, P., Microfluidic DNA amplification-A review (2009) Anal. Chim. Acta., 638, pp. 115-125
Shaw, K.J., Docker, P.T., Yelland, J.V., Dyer, C.E., Greenman, J., Greenwaya, G.M., Haswell, S.J., Rapid PCR amplification using a microfluidic device with integrated microwave heating and air impingement cooling (2010) Lab Chip, 10, pp. 1725-1728
Li, Y., Zhang, C., Xing, D., Integrated microfluidic reverse transcription-polymerase chain reaction for rapid detection of food-or waterborne pathogenic rotavirus (2011) Anal. Biochem., 415, pp. 87-96
Zhang, H., Jenkins, G., Zou, Y., Zhu, Z., Yang, C.J., Massively parallel single-molecule and single-cell emulsion reverse transcription polymerase chain reaction using Agarose droplet microfluidics (2012) Anal. Chem., 84, pp. 3599-3606
Luna-Vera, F., Alvarez, J.C., Adsorption kinetics of proteins in plastic microfluidic channels: Real-time monitoring of lysozyme adsorption by pulsed streaming potentials Biosens (2010) Bioelectron., 25, pp. 1539-1543
Christensen, T.B., Pedersen, C.M., Gröndahl, K.G., Jensen, T.G., Sekulovic, A., Bang, D.D., Wolff, A., PCR biocompatibility of lab-on-a-chip and MEMS materials (2007) J. Micromech. Microeng., 17, pp. 1527-1532
Erill, I., Campoy, S., Erill, N., Barbe, J., Aguilo, J., Biochemical analysis and optimization of inhibition and adsorption phenomena in glass-silicon PCR-chips (2003) Sens. Actuator. B, 96, pp. 685-692
Kricka, L.J., Wilding, P., Microchip PCR (2003) Anal. Bioanal. Chem., 377, pp. 820-825
Felbel, J., Bieber, I., Pipper, J., Kohler, J.M., Investigations on the compatibility of chemically oxidized silicon (SiOx)-surfaces for applications towards chip-based polymerase chain reaction (2004) Chem. Eng. J., 101, pp. 333-338
Panaro, N.J., Lou, X.J., Fortina, P., Kricka, L.J., Wilding, P., Surface effects on PCR reactions in multichip microfluidic platforms (2004) Biomed. Microdevices, 6, pp. 75-80
Zanoli, L.M., Licciardello, M., D'Agata, R., Lantano, C., Calabretta, A., Corradini, R., Marchelli, R., Spoto, G., Peptide nucleic acid molecular beacons for the detection of PCR amplicons in droplet-based microfluidic devices (2012) Anal. Bioanal. Chem., , doi: 10.1007/s00216-011-5638-3
Christopher, G.F., Anna, S.L., Microfluidic methods for generating continuous droplet streams (2007) J. Phys. D Appl. Phys., 40, pp. R319-R336
Griffiths, A.D., Tawfik, D.S., Miniaturising the laboratory in emulsion droplets (2006) Trends Biotechnol., 24, pp. 395-402
Fair, R.B., Digital microfluidics: Is a true lab-on-a-chip possible? (2007) Microfluid. Nanofluid., 3, pp. 245-281
Zeng, Y., Novak, R., Shuga, J., Smith, M.T., Mathies, R.A., High-performance single cell genetic analysis using microfluidic emulsion generator arrays (2010) Anal. Chem., 82, pp. 3183-3190
Kiss, M.M., Ortoleva-Donnelly, L., Beer, N.R., Warner, J., Bailey, C.G., Colston, B.W., Rothberg, J.M., Leamon, J.H., High-throughput quantitative polymerase chain reaction in picoliter droplets (2008) Anal. Chem., 80, pp. 8975-8981
Hua, Z., Rouse, J.L., Eckhardt, A.E., Srinivasan, V., Pamula, V.K., Schell, W.A., Benton, J.L., Pollack, M.G., Multiplexed real-time polymerase chain reaction on a digital microfluidic platform (2010) Anal. Chem., 82, pp. 2310-2316
Zhu, Z., Jenkins, G., Zhang, W., Zhang, M., Guan, Z., Yang, C.J., Single-molecule emulsion PCR in microfluidic droplets (2012) Anal. Bioanal. Chem., 403, pp. 2127-2143
Notomi, T., Okayama, H., Masubuchi, H., Yonekawa, T., Watanabe, K., Amino, N., Hase, T., Loop-mediated isothermal amplification of DNA (2000) Nucleic Acids Res., p. 28. , doi: 101093/nar/28.12.e63
Curtis, K.A., Rudolph, D.L., Owen, S.M., Rapid detection of HIV-1 by reverse-transcription, loop-mediated isothermal amplification (RT-LAMP) (2008) J. Virol. Methods, 151, pp. 264-270
Hong, T.C., Mai, Q.L., Cuong, D.V., Development and evaluation of a novel loop-mediated isothermal amplification method for rapid detection of severe acute respiratory syndrome coronavirus (2004) J. Clin. Microbiol., 42, pp. 1956-1961
Misawa, Y., Yoshida, A., Saito, R., Yoshida, H., Okuzumi, K., Ito, N., Okada, M., Koike, K., Application of loop-mediated isothermal amplifi cation technique to rapid and direct detection of methicillin-resistant Staphylococcus aureus (MRSA) in blood cultures (2007) J. Infect. Chemother., 13, pp. 134-140
Ohtsuka, K., Yanagawa, K., Takatori, K., Hara-Kudo, Y., Detection of Salmonella enterica in naturally contaminated liquid eggs by loop-mediated isothermal amplification, and characterization of salmonella isolates (2005) Appl. Environ. Microbiol., 71, pp. 6730-6735
Liu, C., Mauk, M.G., Bau, H.H., A disposable, integrated loop-mediated isothermal amplification cassette with thermally actuated valves (2011) Microfluid. Nanofluid., 11, pp. 209-220
Yoshida, A., Nagashima, S., Ansai, T., Tachibana, M., Kato, H., Watari, H., Notomi, T., Takehara, T., Loop-mediated isothermal amplification method for rapid detection of the periodontopathic bacteria Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola (2005) J. Clin. Microbiol., 43, pp. 2418-2424
Mori, Y., Nagamine, K., Tomita, N., Notomi, T., Detection of loop-mediated isothermal amplification reaction by turbidity derived from magnesium pyrophosphate formation (2001) Biochem. Biophys. Res. Commun., 289, pp. 150-154
Nakamura, N., Fukuda, T., Nonen, S., Hashimoto, K., Azuma, J., Gemma, N., Simple and accurate determination of CYP2D6 gene copy number by a loop-mediated isothermal amplification method and an electrochemical DNA chip Clin (2010) Chim. Acta., 411, pp. 568-573
Iwamoto, T., Sonobe, T., Hayashi, K., Loop-mediated isothermal amplification for direct detection of mycobacterium tuberculosis complex, M. avium, and M. intracellulare in sputum samples (2003) J. Clin. Microbiol., 41, pp. 2616-2622
Lee, S.Y., Huang, J.G., Chuang, T.L., Sheu, J.C., Chuang, Y.K., Holl, M., Meldrum, D.R., Lin, C.W., Compact optical diagnostic device for isothermal nucleic acids amplification (2008) Sens. Actuator. B, 133, pp. 493-501
Lee, S.Y., Lee, C.N., Holl, M., Meldrum, D.R., Lin, C.W., Efficient, specific, compact hepatitis B diagnostic device: Optical detection of the hepatitis B virus by isothermal amplification (2007) Sens. Actuator. B, 127, pp. 598-605
Hataoka, Y., Zhang, L.H., Mori, Y., Tomita, N., Notomi, T., Baba, Y., Analysis of specific gene by integration of isothermal amplification and electrophoresis on poly(methyl methacrylate) microchips (2004) Anal. Chem., 76, pp. 3689-3693
Fang, X., Liu, Y., Kong, J., Jiang, X., Loop-mediated isothermal amplification integrated on microfluidic chips for point-of-care quantitative detection of pathogens (2010) Anal. Chem., 82, pp. 3002-3006
Lam, L., Sakakihara, S., Ishizuka, K., Takeuchi, S., Arata, H.F., Fujita, H., Noji, H., Loop-mediated isothermal amplification of a single DNA molecule in polyacrylamide gel-based microchamber (2008) Biomed. Microdevices, 10, pp. 539-546
Safavieh, M., Ahmed, M.U., Tolba, M., Zourob, M., Microfluidic electrochemical assay for rapid detection and quantification of Escherichia coli (2012) Biosens. Bioelectron., 31, pp. 523-528
Nakamura, N., Ito, K., Takahashi, M., Hashimoto, K., Kawamoto, M., Yamanaka, M., Taniguchi, A., Gemma, N., Detection of six single-nucleotide polymorphisms associated with rheumatoid arthritis by a loop-mediated isothermal amplification method and an electrochemical DNA chip (2007) Anal. Chem., 79, pp. 9484-9493
Lee, T.M., Over-the-counter biosensors: Past, present, and future (2008) Sensors, 8, pp. 5535-5559
Abdel-Monem, M., Hoffmann-Berling, H., Enzymic unwinding of DNA 1: Purification and characterization of a DNA-dependent ATPase (1976) Escherichia coli. Eur. J. Biochem., 65, pp. 431-440
Abdel-Monem, M., Durwald, H., Hoffmann-Berling, H., Enzymic unwinding of DNA. 2. Chain separation by an ATP-dependent DNA unwinding enzyme. (1976) Eur. J. Biochem., 65, pp. 441-449
Vincent, M., Xu, Y., Kong, H., Helicase-dependent isothermal DNA amplification (2004) EMBO Rep., 5, pp. 795-800
Jeong, Y.-J., Park, K., Kim, D.-E., Isothermal DNA amplification in vitro: The helicase-dependent amplification system (2009) Cell. Mol. Life Sci., 66, pp. 3325-3336
Tuteja, N., Tuteja, R., Unraveling DNA helicases. Motif, structure, mechanism and function (2004) Eur. J. Biochem., 271, pp. 1849-1863
Jankowsky, E., RNA helicases at work: Binding and rearranging (2011) Trends Biochem. Sci., 36, pp. 19-29
Pyle, A.M., Translocation and unwinding mechanisms of RNA and DNA helicases (2008) Annu. Rev. Biophys., 37, pp. 317-336
Hall, M.C., Matson, S.W., Helicase motifs: The engine that powers DNA unwinding (1999) Mol. Microbiol., 34, pp. 867-877
Runyon, G.T., Lohman, T.M., Escherichia coli helicase II (uvrD) protein can completely unwind fully duplex linear and nicked circular DNA (1989) J. Biol. Chem., 264, pp. 17502-17512
Furukohri, A., Nishikawa, Y., Akiyama, M.T., Maki, H., Interaction between Escherichia coli DNA polymerase IV and single-stranded DNA-binding protein is required for DNA synthesis on SSB-coated DNA (2012) Nucleic Acids Res., 40, pp. 6039-6048
Shereda, R.D., Kozlov, A.G., Lohman, T.M., Cox, M.M., Keck, J.L., SSB as an organizer/mobilizer of genome maintenance complexes (2008) Crit. Rev. Biochem. Mol. Biol., 43, pp. 289-318
Mechanic, L.E., Frankel, B.A., Matson, S.W., Escherichia coli MutL loads DNA helicase II onto DNA (2000) J. Biol. Chem., 275, pp. 38337-38346
Matson, S.W., Robertson, A.B., The UvrD helicase and its modulation by the mismatch repair protein MutL (2006) Nucleic Acids Res., 34, pp. 4089-4097
An, L., Tang, W., Ranalli, T.A., Kim, H.J., Wytiaz, J., Kong, H., Characterization of a thermostable UvrD helicase and its participation in helicase-dependent amplification (2005) J. Biol. Chem., 280, pp. 28952-28958
Goldmeyer, J., Kong, H., Tang, W., Development of a novel one-tube isothermal reverse transcription thermophilic helicase-dependent amplification platform for rapid RNA detection (2007) J. Mol. Diagn., 9, pp. 639-644
Tong, Y., Tang, W., Kim, H.J., Pan, X., Ranalli, T., Kong, H., Development of isothermal TaqMan assays for detection of biothreat organisms (2008) Biotechniques, 45, pp. 543-557
Andresen, D., von Nickisch-Rosenegk, M., Bier, F.F., Helicase dependent on chip-amplification and its use in multiplex pathogen detection (2009) Clin. Chim. Acta., 403, pp. 244-248
http://www.biohelix.com/, IsoAmp II tHDA Kit
Biohelix Corporation: Beverly, MA, USA. Available online, (accessed on 7 November 2012)Ramalingam, N., San, T.C., Kai, T.J., Mak, M.Y.M., Gong, H.-Q., Microfluidic devices harboring unsealed reactors for real-time isothermal helicase-dependent amplification (2009) Microfluid. Nanofluid., 7, pp. 325-336
Tong, Y., Lemieux, B., Kong, H., Multiple strategies to improve sensitivity, speed and robustness of isothermal nucleic acid amplification for rapid pathogen detection (2011) BMC Biotechnol., p. 11. , doi: 101186/1472-6750-11-50
Mahalanabis, M., Do, J., AlMuayad, H., Zhang, J.Y., Klapperich, C.M., An integrated disposable device for DNA extraction and helicase dependent amplification (2010) Biomed. Microdevices, 12, pp. 353-359
Baner, J., Nilsson, M., Mendel-Hartvig, M., Landergren, U., Signal amplification of padlock probes by rolling circle replication (1998) Nucl. Acids Res., 26, pp. 5073-5078
Mothershed, E.A., Whitney, A.M., Nucleic acid-based methods for the detection of bacterial pathogens: Present and future considerations for the clinical laboratory (2006) Clin. Chim. Acta., 363, pp. 206-220
Nilsson, M., Malmgren, H., Samiotaki, M., Kwiatkowski, M., Chowdhary, B.P., Landegren, U., Padlock probes: Circularizing oligonucleotides for localized DNA detection (1994) Science, 265, pp. 2085-2088
Lizardi, P.M., Huang, X.H., Zhu, Z.R., Bray-Ward, P., Thomas, D.C., Ward, D.C., Mutation detection and single-molecule counting using isothermal rolling-circle amplification (1998) Nat. Genet., 19, pp. 225-232
Jarvius, J., Melin, J., Göransson, J., Stenberg, J., Fredriksson, S., Gonzalez-Rey, C., Bertilsson, S., Nilsson, M., Digital quantification using amplified single-molecule detection (2006) Nat. Mater., 3, pp. 725-727
Melin, J., Jarvius, J., Gransson, J., Nilsson, M., Homogeneous amplified single-molecule detection: Characterization of key parameters (2007) Anal. Biochem., 368, pp. 230-238
Johne, R., Mueller, H., Rector, A., van Ranst, M., Stevens, H., Rolling-circle amplification of viral DNA genomes using phi29 polymerase (2009) Trends Microbiol., 17, pp. 205-211
Hutchison, C.A., Smith, H.O., Pfannkoch, C., Venter, J.C., Cell-free cloning using phi29 DNA polymerase (2005) Proc. Natl. Acad. Sci., 102, pp. 17332-17336
Mahmoudian, L., Kaji, N., Tokeshi, M., Nilsson, M., Baba, Y., Rolling circle amplification and circle-to-circle amplification of a specific gene integrated with electrophoretic analysis on a single chip (2008) Anal. Chem., 80, pp. 2483-2490
Dahl, F., Baner, J., Gullberg, M., Mendel-Hartvig, M., Landegren, U., Nilsson, M., Circle-to-circle amplification for precise and sensitive DNA analysis (2004) Proc. Natl. Acad. Sci. USA, 101, pp. 4548-4553
Mahmoudian, L., Melin, J., Mohamadi, M.R., Yamada, K., Ohta, M., Kaji, N., Tokeshi, M., Baba, Y., Microchip electrophoresis for specific gene detection of the pathogenic bacteria V (2008) cholerae by circle-to-circle amplification. Anal. Sci., 24, pp. 327-332
Mazutis, L., Araghi, A.F., Miller, O.J., Baret, J.C., Frenz, L., Janoshazi, A., Taly, V., Ryckelynck, M., Droplet-based microfluidic systems for high-throughput single dna molecule isothermal amplification and analysis (2009) Anal. Chem., 81, pp. 4813-4821
Juul, S., Nielsen, C.J., Labouriau, R., Roy, A., Tesauro, C., Jensen, P.W., Harmsen, C., Knudsen, B.R., Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing plasmodium parasites based on enzyme activity measurement (2012) ACS Nano, , doi: 10.1021/nn3038594
Dean, F.B., Hosono, S., Fang, L., Wu, X., Faruqi, A.F., Bray-Ward, P., Sun, Z., Lasken, R.S., Comprehensive human genome amplification using multiple displacement amplification (2002) Proc. Natl. Acad. Sci., 99, pp. 5261-5266
Blanco, L., Bernad, A., Lazaro, J.M., Martin, G., Garmendia, C., Salas, M., Highly efficient DNA synthesis by the phage phi 29 DNA polymerase, Symmetrical mode of DNA replication. (1989) J. Biol. Chem., 264, pp. 8935-8940
Nelson, J.R., Cai, Y.C., Giesler, T.L., Farchaus, J.W., Sundaram, S.T., Ortiz-Rivera, M., Hosta, L.P., Fuller, C.W., TempliPhi, phi29 DNA polymerase based rolling circle amplification of templates for DNA sequencing (2002) Biotechniques, 32, pp. S44-S47
Ling, L.L., Keohavong, P., Dias, C., Thilly, W.G., Optimization of the polymerase chain reaction with regard to fidelity: Modified T7, Taq, and vent DNA polymerases (1991) Genome Res., 1, pp. 63-69
Keohavong, P., Thilly, W.G., Fidelity of DNA polymerases in DNA amplification (1989) Proc. Natl. Acad. Sci., 86, pp. 9253-9257
Hosono, S., Faruqi, A.F., Dean, F.B., Du, Y., Sun, Z., Wu, X., Du, J., Lasken, R.S., Unbiased whole genome amplification directly from clinical samples (2003) Genome Res., 13, pp. 954-964
Raghunathan, A., Ferguson Jr., H.R., Bornarth, C.J., Song, W., Driscoll, M., Lasken, R.S., Genomic DNA amplification from a single bacterium (2005) Appl. Environ. Microbiol., 71, pp. 3342-3347
Marcy, Y., Ishoey, T., Lasken, R.S., Stockwell, T.B., Walenz, B.P., Halpern, A.L., Beeson, K.Y., Quake, S.R., Nanoliter reactors improve multiple displacement amplification of genomes from single cells (2007) PloS Genet., p. 3. , doi: 101371/journal.pgen.0030155
Piepenburg, O., Williams, C.H., Stemple, D.L., Armes, N.A., DNA detection using recombination proteins (2006) PloS Biol., p. 4. , doi: 101371/journal.pbio.0040204
Lutz, S., Weber, P., Focke, M., Faltin, B., Hoffmann, J., Müller, C., Mark, D., von Stetten, F., Microfluidic lab-on-a-foil for nucleic acid analysis based on isothermal recombinase polymerase amplification (RPA) (2010) Lab Chip, 10, pp. 887-893
Hakenberg, S., Hügle, M., Weidmann, M., Hufert, F., Dame, G., Urban, G.A., A phaseguided passive batch microfluidic mixing chamber for isothermal amplification (2012) Lab Chip, 12, pp. 4576-4580
Vulto, P., Podszun, S., Meyer, P., Hermann, C., Manz, A., Urban, G.A., Phaseguides: A paradigm shift in microfluidic priming and emptying (2011) Lab Chip, 11, pp. 1596-1602
Paul, N., Shum, J., Le, T., Hot start PCR (2010) Methods Mol. Biol., 630, pp. 301-318
Shen, F., Davydova, E.K., Du, W., Kreutz, J.E., Piepenburg, O., Ismagilov, R.F., Digital isothermal quantification of nucleic acids via simultaneous chemical initiation of recombinase polymerase amplification reactions on SlipChip (2011) Anal. Chem., 83, pp. 3533-3540
Compton, J., Nucleic acid sequence-based amplification (1991) Nature, 350, pp. 91-92
Deiman, B., van Aarle, P., Sillekens, P., Characteristics and applications of nucleic acid sequence-based amplification (NASBA) (2002) Mol. Biotechnol., 20, pp. 163-179
Yates, S., Penning, M., Goudsmit, J., Frantzen, I., van de Weijer, B., van Strijp, D., van Gemen, B., Quantitative detection of hepatitis B virus DNA by real-time nucleic acid sequence-based amplification with molecular beacon detection (2001) J. Clin. Microbiol., 39, pp. 3656-3665
van Gemen, B., van Beuningen, R., Nabbe, A., van Strijp, D., Jurriaans, S., Lens, P., Kievits, T., A one-tube quantitative HIV-1 RNA NASBA nucleic acid amplification assay using electrochemiluminiscent (ECL) labelled probes (1994) J. Virol. Methods, 49, pp. 157-168
Shan, S., Ko, L.S., Collins, R.A., Wu, Z., Chen, J., Chan, K.Y., Xing, J., Yu, A.C., Comparison of nucleic acid-based detection of avian influenza H5N1 with virus isolation (2003) Biochem. Biophys. Res. Commun., 302, pp. 377-383
Connelly, J.T., Nugen, S.R., Borejsza-Wysocki, W., Durst, R.A., Montagna, R.A., Baeumner, A.J., Human pathogenic Cryptosporidium species bioanalytical detection method with single oocyst detection capability (2008) Anal. Bioanal. Chem., 391, pp. 487-495
Nugen, S.R., Asiello, P.J., Connelly, J.T., Baeumner, A.J., PMMA biosensor for nucleic acids with integrated mixer and electrochemical detection (2009) Biosens. Bioelectron., 24, pp. 2428-2433
Wang, Y., Li, J., Jin, J., Wang, H., Tang, H., Yang, R., Wang, K., Strategy for molecular beacon binding readout: Separating molecular recognition element and signal reporter (2009) Anal. Chem., 81, pp. 9703-9709
Wang, K., Tang, Z., Yang, C.J., Kim, Y., Fang, X., Li, W., Wu, Y., Tan, W., Molecular engineering of DNA: Molecular beacons (2009) Angew. Chem. Int. Edit., 48, pp. 856-870
Gore, H.M., Wakeman, C.A., Hull, R.M., McKillip, J.L., Real-time molecular beacon NASBA reveals hblc expression from Bacillus spp (2003) in milk. Biochem. Biophys. Res. Commun., 311, pp. 386-390
Nadal, A., Coll, A., Cook, N., Pla, M., A molecular beacon-based real time NASBA assay for detection of Listeria monocytogenes in food products: Role of target mRNA secondary structure on NASBA design (2007) J. Microbiol. Methods, 68, pp. 623-632
Gulliksen, A., Solli, L., Karlsen, F., Rogne, H., Hovig, E., Nordstrom, T., Sirevag, R., Real-time nucleic acid sequence-based amplification in nanoliter volumes (2004) Anal. Chem., 76, pp. 9-14
Gulliksen, A., Keegan, H., Martin, C., O'Leary, J., Solli, L.A., Falang, I.M., Grønn, P., Furuberg, L., Towards a "sample-in, answer-out" point-of-care platformfor nucleic acid extraction and amplification: Using an HPV E6/E7mRNAModel System (2012) J. Oncol., , doi:10.1155/2012/905024
Dimov, I.K., Garcia-Cordero, J.L., O'Grady, J., Poulsen, C.R., Viguier, C., Kent, L., Daly, P., Lee, L.P., Integrated microfluidic tmRNA purification and real-time NASBA device for molecular diagnostics (2008) Lab Chip, 8, pp. 2071-2078
Zhao, X., Dong, T., Yang, Z., Pires, N., Hoivik, N., Compatible immuno-NASBA LOC device for quantitative detection of waterborne pathogens: Design and validation (2012) Lab Chip, 12, pp. 602-612
Isothermal amplification methods for the detection of nucleic acids in microfluidic devices
Diagnostic tools for biomolecular detection need to fulfill specific requirements in terms of sensitivity, selectivity and high-throughput in order to widen their applicability and to minimize the cost of the assay. The nucleic acid amplification is a key step in DNA detection assays. It contributes to improving the assay sensitivity by enabling the detection of a limited number of target molecules. The use of microfluidic devices to miniaturize amplification protocols reduces the required sample volume and the analysis times and offers new possibilities for the process automation and integration in one single device. The vast majority of miniaturized systems for nucleic acid analysis exploit the polymerase chain reaction (PCR) amplification method, which requires repeated cycles of three or two temperature-dependent steps during the amplification of the nucleic acid target sequence. In contrast, low temperature isothermal amplification methods have no need for thermal cycling thus requiring simplified microfluidic device features. Here, the use of miniaturized analysis systems using isothermal amplification reactions for the nucleic acid amplification will be discussed.
Diagnostic tools for biomolecular detection need to fulfill specific requirements in terms of sensitivity, selectivity and high-throughput in order to widen their applicability and to minimize the cost of the assay. The nucleic acid amplification is a key step in DNA detection assays. It contributes to improving the assay sensitivity by enabling the detection of a limited number of target molecules. The use of microfluidic devices to miniaturize amplification protocols reduces the required sample volume and the analysis times and offers new possibilities for the process automation and integration in one single device. The vast majority of miniaturized systems for nucleic acid analysis exploit the polymerase chain reaction (PCR) amplification method, which requires repeated cycles of three or two temperature-dependent steps during the amplification of the nucleic acid target sequence. In contrast, low temperature isothermal amplification methods have no need for thermal cycling thus requiring simplified microfluidic device features. Here, the use of miniaturized analysis systems using isothermal amplification reactions for the nucleic acid amplification will be discussed.
Isothermal amplification methods for the detection of nucleic acids in microfluidic devices
Isothermal amplification methods for the detection of nucleic acids in microfluidic devices
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Autiero I, Vitagliano L
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (677 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Avitabile C, Saviano M, D'Andrea LD, Bianchi N, Fabbri E, Brognara E, Gambari R, Romanelli A
* Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation (882 views)
Artif Dna Pna Xnaartificial Dna Pna & Xna (ISSN: 1949-9096, 1949-0968, 1949-095x), 2012 Apr; 3(2): 88-96.
Impact Factor: 0
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Improta R, Barone V
* Interplay between "neutral" and "charge-transfer" excimers rules the excited state decay in adenine-rich polynucleotides (744 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2011 Dec 9; 50(50): 12016-12019.
Impact Factor: 13.455
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications (607 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2011 Sep 30; 415(1-2): 206-210.
Impact Factor: 3.35
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Nucleobase-containing peptides: a spectroscopic study of their properties and nucleic acids recognition ability (461 views)
Eur Biophys J (ISSN: 0175-7571, 1432-1017, 0175-7571linking), 2011 Sep; 40: N/D-N/D.
Impact Factor: 2.139
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Scognamiglio PL, Doti N, Grieco P, Pedone C, Ruvo M, Marasco D
* Discovery Of Small Peptide Antagonists Of Ped/Pea15-D4alpha Interaction From Simplified Combinatorial Libraries (594 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 May; 77(5): 319-327.
Impact Factor: 2.282
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Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (621 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
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Roviello GN, Ricci A, Bucci EM, Pedone C
* Synthesis, biological evaluation and supramolecular assembly of novel analogues of peptidyl nucleosides (1680 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1773-1778.
Impact Factor: 3.534
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Evidences for supramolecular organization of nucleopeptides: Synthesis, spectroscopic and biological studies of a novel dithymine l-serine tetrapeptide (719 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 Apr; 7(4): 1073-1080.
Impact Factor: 3.534
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D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (484 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
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Moccia M, Roviello GN, Bucci EM, Pedone C, Saviano M
* Synthesis of a l-lysine-based alternate alpha, epsilon-peptide: A novel linear polycation with nucleic acids-binding ability (587 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2010 Sep 15; 397(1-2): 179-183.
Impact Factor: 3.607
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (412 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
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Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (510 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
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Russo Krauss I, Merlino A, Randazzo A, Mazzarella L, Sica F
* Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer (507 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309, 1532-2335electronic), 2010 Aug 1; 66(Pt8): 961-963.
Impact Factor: 0.563
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Avitabile C, Moggio L, D'Andrea LD, Pedone C, Romanelli A
* Development of an efficient and low-cost protocol for the manual PNA synthesis by Fmoc chemistry (633 views)
Tetrahedron Lett (ISSN: 0040-4039), 2010 Jul 21; 51(29): 3716-3718.
Impact Factor: 2.618
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Gustavsson T, Improta R, Markovitsi D
DNA/RNA: Building blocks of life under UV irradiation (367 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2010 Jul 1; 1(13): 2025-2030.
Impact Factor: 6.687
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Roviello GN, Benedetti E, Pedone C, Bucci EM
* Nucleobase-containing peptides: An overview of their characteristic features and applications (963 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jun; 39(1): 45-57.
Impact Factor: 4.106
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA (590 views)
Lect Notes Electr Eng, 2010 May 15; 91LNEE: 485-488.
Impact Factor: 0
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (640 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
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Pensato S, Renda M, Leccia F, Saviano M, D'Andrea LD, Pedone C, Pedone PV, Romanelli A
* PNA zipper as a dimerization tool: development of a bZip mimic (698 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 May; 93(5): 434-441.
Impact Factor: 2.572
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Roviello GN, Gröschel S, Pedone C, Diederichsen U
* Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras (1111 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2010 May; 38(5): 1301-1309.
Impact Factor: 4.106
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Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (544 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
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Roviello GN, Musumeci D, De Cristofaro A, Capasso D, Di Gaetano S, Bucci EM, Pedone C
* Alternate dab-aegPNAs: synthesis, nucleic acid binding studies and biological activity (586 views)
Mol Biosyst (ISSN: 1742-2051, 1742-206x, 1742-2051electronic), 2010 Jan; 6(1): 199-205.
Impact Factor: 3.825
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Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA
* Cell recruitment and transfection in gene activated collagen matrix (479 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.
Impact Factor: 7.883
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Roviello GN, Musumeci D, Pedone C, Bucci EM
* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (669 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
Impact Factor: 4.106
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D'Agata R, Breveglieri G, Zanoli L, Borgatti M, Spoto G, Gambari R
* Surface Plasmon Resonance Imaging (SPR-I), peptide nucleic acid (PNA) probes and nanoparticle-enhancement for PCR-free ultrasensitive detection of beta-thalassemia mutations in human genomic DNA (335 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2010; 26: N/D-N/D.
Impact Factor: 1.814
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Improta R, Santoro F, Barone V, Lami A
* Vibronic model for the quantum dynamical study of the competition between bright and charge-transfer excited states in single-strand polynucleotides: the adenine dimer case (354 views)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic, 1089-5639linking), 2009 Dec 31; 113(52): 15346-15354.
Impact Factor: 2.899
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Ruggiero A, Di Maro A, Severino V, Chambery A, Berisio R
* Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage (489 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1135-1142.
Impact Factor: 2.605
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (1173 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
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Grasso G, D'Agata R, Zanoli L, Spoto G
* Microfluidic networks for surface plasmon resonance imaging real-time kinetics experiments (319 views)
Microchemical Journal (ISSN: 0026-265x), 2009 Sep; 93(1): 82-86.
Impact Factor: 2.579
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Grasso G, Bush AI, D'Agata R, Rizzarelli E, Spoto G
* Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme (736 views)
Eur Biophys J (ISSN: 1432-1017, 0175-7571, 0175-7571linking), 2009 Apr; 38(4): 407-414.
Impact Factor: 2.437
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (544 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (700 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Santoro F, Barone V, Improta R
* The Excited States Decay Of The A-T Dna: A Pcm/Td-Dft Study In Aqueous Solution Of The (9-Methyl-Adenine) 2 (1-Methyl-Thymine) 2 Stacked Tetramer (320 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2009; 131(42): 15232-15245.
Impact Factor: 8.58
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (683 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (561 views)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
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Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (426 views)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
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D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (479 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Improta R, Barone V
The excited states of adenine and thymine nucleoside and nucleotide in aqueous solution: A comparative study by time-dependent DFT calculations (327 views)
Theor Chem Acc (ISSN: 1432-881x), 2008 Jul; 120(4-6): 491-497.
Impact Factor: 2.37
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Santoro F, Barone V, Improta R
* Can TD-DFT calculations accurately describe the excited states behavior of stacked nucleobases? The cytosine dimer as a test case (404 views)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic, 0192-8651linking), 2008 Apr 30; 29(6): 957-964.
Impact Factor: 3.39
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Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (503 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
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Pensato S, D'Andrea LD, Pedone C, Romanelli A
* New synthetic route to gamma-mercaptomethyl PNA monomers (483 views)
Synth Commun Synthetic Communications (ISSN: 0039-7911), 2008; 38(15): 2499-2506.
Impact Factor: 0.981
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Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (448 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
Impact Factor: 0.1
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (521 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Zanoli L, Dagata R, Spoto G
* Surface plasmon-based optical detection of DNA peptide nucleic acids (389 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 165-174.
Impact Factor: 0.1
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Tedeschi G, Dinacci D, Lavorgna L, Prinster A, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Servillo G, Bresciamorra V, Orefice G, Paciello M, Brunetti A, Paolillo A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone I, Salvatore M, Bonavita V, Alfano B
* Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability (674 views) (PDF 273 views)
J Neurol Sci (ISSN: 0022-510x, 0022-510xlinking), 2007 Dec 15; 263(1-2): 15-19.
Impact Factor: 2.315
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Pensato S, Saviano M, Romanelli A
* New peptide nucleic acid analogues: synthesis and applications (679 views)
Expert Opinion On Biological Therapy (ISSN: 1471-2598), 2007 Sep; 7(8): 1219-1232.
Impact Factor: 2.815
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, Pedone C
* Dabpna: Design, Synthesis And Nucleic Acids Binding Studies (483 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1307-1310.
Impact Factor: 0.723
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Santoro F, Barone V, Improta R
* Influence of base stacking on excited-state behavior of polyadenine in water, based on time-dependent density functional calculations (751 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007; 104(24): 9931-9936.
Impact Factor: 9.598
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (325 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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Moccia M, Musumeci D, Valente M, Roviello GN, Sapio R, Pedone C, Bucci EM
* Thermodynamic studies on PNA and PNA/DNA dendrimer formation (333 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1173-1176.
Impact Factor: 0.723
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Santoro F, Gustavsson T, Lami S, Barone V, Improta R
* Towards the understanding of the excited state dynamics of nucleic acids: Solvent and stacking effect on the photophysical behavior of nucleobases (351 views)
Aip Conf Proc (ISSN: 0094-243x), 2007; 963(2): 631-634.
Impact Factor: 0
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Santoro F, Barone V, Gustavsson T, Improta R
* Solvent effect on the singlet excited-state lifetimes of nucleic acid bases: A computational study of 5-fluorouracil and uracil in acetonitrile and water (1041 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Dec 20; 128(50): 16312-16322.
Impact Factor: 7.696
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Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (610 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
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Musumeci D, Valente M, Capasso D, Palumbo R, Gorlach M, Schmidtke M, Zell R, Roviello GN, Sapio R, Pedone C, Bucci EM
* A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis (551 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
Impact Factor: 1.801
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Bernini E De Nuccio R, Brescia F, Minardo A, Zeni L, Sarro PM, Palumbo R, Scarf MR
* Development and characterization of an integrated silicon micro flow cytometer (409 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2006; 386(5): 1267-1272.
Impact Factor: 2.591
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (569 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (489 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
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Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A
* A crevice adjoining the ribosome tunnel: Hints for cotranslational folding (469 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Jun 13; 579(15): 3207-3213.
Impact Factor: 3.415
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (513 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (559 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
Impact Factor: 3.3
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Improta R, Barone V
* Absorption and fluorescence spectra of uracil in the gas phase and in aqueous solution: A TD-DFT quantum mechanical study (422 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Nov 10; 126(44): 14320-14321.
Impact Factor: 6.903
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (683 views)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Berisio R, Granata V, Vitagliano L, Zagari A
* Imino acids and collagen triple helix stability: Characterization of collagen-like polypeptides containing Hyp-Hyp-Gly sequence repeats (555 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Sep 22; 126(37): 11402-11403.
Impact Factor: 6.903
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Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (514 views)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Impact Factor: 1.567
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (371 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Improta R, Barone V
* Interplay of electronic, environmental, and vibrational effects in determining the hyperfine coupling constants of organic free radicals (339 views)
Chem Rev (ISSN: 0009-2665), 2004 Mar; 104(3): 1231-1253.
Impact Factor: 20.233
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (451 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Musumeci D, Roviello GN, Valente M, Sapio R, Pedone C, Bucci EM
* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (494 views)
Biopolymers, 2004; 76(6): 535-542.
Impact Factor: 2.248
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Ohlenschlager O, Wohnert J, Bucci E, Seitz S, Hafner S, Ramachandran R, Zell R, Gorlach M
* The Structure of the Stemloop D Subdomain of Coxsackievirus B3 Cloverleaf RNA and Its Interaction with the Proteinase 3C (771 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2004; 12(2): 237-248.
Impact Factor: 5.185
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Menchise V, De Simone G, Tedeschi T, Corradini R, Sforza S, Marchelli R, Capasso D, Saviano M, Pedone C
* Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a D-lysine-based chiral PNA-DNA duplex (2411 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2003 Oct 14; 100(21): 12021-12026.
Impact Factor: 10.272
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Bashan A, Zarivach R, Schluenzen F, Agmon I, Harms J, Auerbach T, Baram D, Berisio R, Bartels H, Hansen HAS, Fucini P, Wilson D, Peretz M, Kessler M, Yonath A
* Ribosomal crystallography: Peptide bond formation and its inhibition (641 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003 Sep; 70(1): 19-41.
Impact Factor: 2.733
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (912 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Bashan A, Agmon I, Zarivach R, Schluenzen F, Harms J, Berisio R, Bartels H, Franceschi F, Auerbach T, Hansen HAS, Kossoy E, Kessler M, Yonath A
* Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression (541 views)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2003 Jan; 11(1): 91-102.
Impact Factor: 16.835
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (530 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Gambari R, Borgatti M, Romanelli A, Capasso D, Saviano M, Bianchi N, Lampronti I, Mischiati C, Pedone C
* Transcription factor decoy (TFD) activity of peptide nucleic acids (PNA)-DNA chimeras (372 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2003; 12(Supplement1): N/D-N/D.
Impact Factor: 1.94
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (545 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Berisio R, Vitagliano L, Mazzarella L, Zagari A
* Recent progress on collagen triple helix structure, stability and assembly (662 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2002 Apr; 9(2): 107-116.
Impact Factor: 0.622
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Menchise V, De Simone G, Corradini R, Sforza S, Sorrentino N, Romanelli A, Saviano M, Pedone C
* Crystallization and preliminary X-ray diffraction studies of a D-lysine-based chiral PNA-DNA duplex (422 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2002 Mar; 58(3): 553-555.
Impact Factor: 1.76
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (557 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (576 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (509 views)
Eur J Biochem (ISSN: 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 4.779
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (690 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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Esposito L, Vitagliano L, Zagari A, Mazzarella L
Experimental evidence for the correlation of bond distances in peptide groups detected in ultrahigh-resolution protein structures (384 views)
Protein Eng (ISSN: 0269-2139, 0269-2139print, 0269-2139linking), 2000 Dec; 13(12): 825-828.
Impact Factor: 2.442
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Lombardi A, Marasco D, Maglio O, Di Costanzo L, Nasti F, Pavone V
Miniaturized metalloproteins: Application to iron-sulfur proteins (834 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
Impact Factor: 10.789
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Kramer RZ, Vitagliano L, Bella J, Berisio R, Mazzarella L, Brodsky B, Zagari A, Berman HM
X-ray crystallographic determination of a collagen-like peptide with the repeating sequence (Pro-Pro-Gly) (612 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1998 Jul 24; 280(4): 623-638.
Impact Factor: 5.803
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Bustamante C, Gurrieri S, Pasternack RF, Purrello R, Rizzarelli E
Interaction of water-soluble porphyrins with single- and double-stranded polyribonucleotides (430 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Sep; 34(8): 1099-1104.
Impact Factor: 2.425
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Salvati AM, d'Onofrio G, Berti P, Cappabianca MP, Marsili G, De Philippis C, Cossa L, Quarantelli M, Zini G, Mango G
An assessment of the operating characteristics of Coulter Counter model S-Plus STKR (666 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1991 Mar; 76(2): 94-103.
Impact Factor: 2.56
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Montanaro V, Casamassimi A, D'Urso M, Yoon JY, Freije W, Schlessinger D, Muenke M, Nussbaum RL, Saccone S, Maugeri S
In Situ Hybridization To Cytogenetic Bands Of Yeast Artificial Chromosomes Covering 50% Of Human Xq24-Xq28 Dna (431 views)
Am J Hum Genet, 1991 Feb; 48(2): 183-194.
Impact Factor: 0
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Gurrieri S, Rizzarelli E, Beach D, Bustamante C
Imaging of kinked configurations of DNA molecules undergoing orthogonal field alternating gel electrophoresis by fluorescence microscopy (670 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 1990 Apr 3; 29(13): 3396-3401.
Impact Factor: 4.572
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* Enhanced molecular dynamic simulation studies unravel long-range effects caused by sequence variations and partner binding in RNA aptamers (31 views)
Mol Ther Nucleic Acids (ISSN: 2162-2531linking), 2023 Dec 12; 34: 102039-102039.
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Troisi R, Balasco N, Autiero I, Vitagliano L, Sica F
* Structural Insights into Protein-Aptamer Recognitions Emerged from Experimental and Computational Studies (6 views)
Int J Mol Sci (ISSN: 1422-0067linking), 2023 Nov 14; 24 (22 ): N/D-N/D.
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Sardaru M-C, Marangoci N-L, Palumbo R, Roviello GN, Rotaru A
* Nucleic Acid Probes in Bio-Imaging and Diagnostics: Recent Advances in ODN-Based Fluorescent and Surface-Enhanced Raman Scattering Nanoparticle and Nanostructured Systems (60 views)
Molecules, 2023 Apr; 28: 3561-3561.
Impact Factor: 4.6
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Falanga AP, Terracciano M, Oliviero G, Roviello GN, Borbone N
* Exploring the relationship between G-quadruplex nucleic acids and plants: from plant G-quadruplex function to phytochemical G4 ligands with pharmaceutic potential (57 views)
Pharmaceutics, 2022 Nov 4; N/D: N/D-N/D.
Impact Factor: 6.525
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Greco F, Marzano M, Falanga AP, Terracciano M, Piccialli G, Roviello GN, D , #xerrico S, Borbone N, Oliviero G
* Cytosine-rich oligonucleotides incorporating a non-nucleotide loop: A further step towards the obtainment of physiologically stable i-motif DNA (59 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2022 Oct 31; 219: 626-636.
Impact Factor: 8.025
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Mosseri A, Sancho-albero M, Leone M, Nava D, Secundo F, Maggioni D, De Cola L, Romanelli A
* Chiral Fibers Formation Upon Assembly of Tetraphenylalanine Peptide Conjugated to a PNA Dimer (108 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2022 Jul 1; 28 (37 ): e202200693-N/D.
Impact Factor: 5.476
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Borbone N, Piccialli I, Falanga AP, Piccialli V, Roviello GN, Oliviero G
* Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era (93 views)
International Journal Of Molecular Sciences, 2022 Jun; 23: 4359-4375.
Impact Factor: 5.924
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Greco F, Musumeci D, Borbone N, Falanga AP, D , #xerrico S, Terracciano M, Piccialli I, Roviello GN, Oliviero G
* Exploring the Parallel G-Quadruplex Nucleic Acid World: A Spectroscopic and Computational Investigation on the Binding of the c-myc Oncogene NHE III1 Region by the Phytochemical Polydatin (200 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2022 May 7; 27(9): 2997-3006.
Impact Factor: 4.412
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Diaferia C, Avitabile C, Leone M, Gallo E, Saviano M, Accardo A, Romanelli A
* Diphenylalanine Motif Drives Self-Assembling in Hybrid PNA-Peptide Conjugates (44 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2021 Oct 13; 27(57): 14307-14316.
Impact Factor: 5.236
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Asha H, Green JA, Martinez-fernandez L, Esposito L, Improta R
* Electronic Circular Dichroism Spectra of DNA Quadruple Helices Studied by Molecular Dynamics Simulations and Excitonic Calculations including Charge Transfer States (158 views)
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Impact Factor: 4.411
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Scognamiglio PL, Platella C, Napolitano E, Musumeci D, Roviello GN
* From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides (146 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Jun 10; 26(12): 3558-3558.
Impact Factor: 4.411
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Moreira M, Ruggiero A, Iaccarino E, Barra G, Sandomenico A, Ruvo M, Berisio R
* A structure-based approach for the development of a bicyclic peptide acting as a miniaturized anti-CD55 antibody (123 views) (PDF 27 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2021 May 17; 182: 1455-1462.
Impact Factor: 6.95
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Fik-jaskółka MA, Pospieszna-markiewicz I, Roviello GN, Kubicki M, Radecka-paryzek W, Patroniak V
* Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect (144 views)
Inorg Chem (ISSN: 0020-1669linking, 1520-510x), 2021 Feb 15; 60(4): 2122-2126.
Impact Factor: 5.165
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Moccia M, Mercurio FA, Langella E, Piacenti V, Leone M, Adamo MFA, Saviano M
* Structural Insights on Tiny Peptide Nucleic Acid (PNA) Analogues of miRNA-34a: An in silico and Experimental Integrated Approach (131 views)
Front Chem (ISSN: 2296-2646linking), 2020 Nov 23; 8: 568575-568575.
Impact Factor: 3.693
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Musumeci D, Mokhir A, Roviello GN
* Synthesis and nucleic acid binding evaluation of a thyminyl L-diaminobutanoic acid-based nucleopeptide (198 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2020 Jul; 100: 103862-103870.
Impact Factor: 4.831
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Avitabile C, Diaferia C, Roviello V, Altamura D, Giannini C, Vitagliano L, Accardo A, Romanelli A
* Fluorescence and Morphology of Self-Assembled Nucleobases and Their Diphenylalanine Hybrid Aggregates (276 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2019 Nov 22; 25(65): 14850-14857.
Impact Factor: 5.476
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Piacenti V, Langella E, Autiero I, Nolan JC, Piskareva O, Adamo MFA, Saviano M, Moccia M
* A combined experimental and computational study on peptide nucleic acid (PNA) analogues of tumor suppressive miRNA-34a (279 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2019 Oct; 91: 103165-103165.
Impact Factor: 3.9
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Carella A, Roviello V, Iannitti R, Palumbo R, La Manna S, Marasco D, Trifuoggi M, Diana R, Roviello GN
* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (505 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jan; 121: 77-88.
Impact Factor: 4.784
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Clemente S, Oliviero C, Palma G, D'Avino V, Liuzzi R, Conson M, Pacelli R, Cella L
* Auto- versus human-driven plan in mediastinal Hodgkin lymphoma radiation treatment (284 views)
Radiat Oncol (ISSN: 1748-717xlinking), 2018 Oct 19; 13(1): 202-202.
Impact Factor: 2.862
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Marr K, Jakimovski D, Mancini M, Carl E, Zivadinov R
* Jugular Venous Flow Quantification Using Doppler Sonography (1324 views)
Ultrasound Med Biol (ISSN: 0301-5629linking, 1879-291xelectronic), 2018 Aug; 44(8): 1762-1769.
Impact Factor: 2.494
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (481 views)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2018 May 15; DOI10.1007/s00726-01: 933-941.
Impact Factor: 3.173
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Musumeci D, Roviello V, Roviello GN
* DNA- and RNA-binding ability of oligoDapT, a nucleobase-decorated peptide, for biomedical applications (2299 views)
Int J Nanomed (ISSN: 1176-9114linking, 1178-2013electronic), 2018 May 1; 2018:13: 2613-2629.
Impact Factor: 4.3
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Chattopadhyay A, Cogdell R, Crespo-hernandez CE, Datta A, De A, Haacke S, Hariharan M, Helliwell J, Hughes A, Improta R, Jones M, Joseph J, Karsili T, Kohler B, Krishnan R, Kuriakose A, L , M , Markovitsi D, Medhi H, Periyasamy G, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Schapiro I, Schertler GFX, Schlichting I, Segarra-marti J, Swaminathan R, V , V , Van Grondelle R, Venkatraman RK, Venkatramani R, Watts A
* Light induced charge and energy transport in nucleic acids and proteins: general discussion (230 views)
Faraday Discuss (ISSN: 1359-6640print, 1359-6640linking), 2018 Apr 1; 207: 153-180.
Impact Factor: 4.194
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Chandra A, Cogdell R, Crespo-hernandez CE, Datta A, Giussani A, Haacke S, Helliwell J, Improta R, Jayasree RS, Jones M, Karsili T, Kohler B, L , M , Mandal I, Markovitsi D, Medhi H, Mishra PP, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Schapiro I, Schlichting I, Segarra-marti J, Sharma A, V , V , Van Grondelle R, Watts A
* Light induced damage and repair in nucleic acids and proteins: general discussion (179 views)
Faraday Discuss (ISSN: 1359-6640print, 1359-6640linking), 2018 Apr 1; 207: 389-408.
Impact Factor: 4.194
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Autiero I, Ruvo M, Improta R, Vitagliano L
* The intrinsic flexibility of the aptamer targeting the ribosomal protein S8 is a key factor for the molecular recognition (440 views)
Bba-Gen Subjects (ISSN: 0304-4165print, 0304-4165linking, 1872-8006electronic), 2018 Apr; 1862(4): 1006-1016.
Impact Factor: 3.829
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Leggio L, Guarino F, Magrì A, Accardi-gheit R, Reina S, Specchia V, Damiano F, Tomasello MF, Tommasino M, Messina A
* Mechanism of translation control of the alternative Drosophila melanogaster Voltage Dependent Anion-selective Channel 1 mRNAs (465 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2018 Mar 28; 8(1): 5347-5347.
Impact Factor: 4.259
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Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
* Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates (1296 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Impact Factor: 5.476
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Bhat V, Cogdell R, Crespo-hernández CE, Datta A, De A, Haacke S, Helliwell J, Improta R, Joseph J, Karsili T, Kohler B, Krishnan R, Mahil LM, Lewis F, Mandal I, Markovitsi D, Mishra PP, Paul S, Periyasamy G, Pradeepkumar PI, Roy Chowdhury P, Sarangi M, Sasikumar D, Schapiro I, Schertler GFX, Schlichting I, Segarra-martí J, Swaminathan R, Vishnu V, Van Grondelle R, Varghese R, Venkatramani R
* Photocrosslinking between nucleic acids and proteins: general discussion (182 views)
Faraday Discussions, 2018; N/D: N/D-N/D.
Impact Factor: 3.427
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Deiana M, Mettra B, Martinez-fernandez L, Mazur LM, Pawlik K, Andraud C, Samoc M, Improta R, Monnereau C, Matczyszyn K
* Specific Recognition of G-Quadruplexes Over Duplex-DNA by a Macromolecular NIR Two-Photon Fluorescent Probe (472 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2017 Dec 7; 8(23): 5915-5920.
Impact Factor: 8.709
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Piras L, Avitabile C, D'Andrea LD, Saviano M, Romanelli A
* Detection of oligonucleotides by PNA-peptide conjugates recognizing the biarsenical fluorescein complex FlAsH-EDT2 (359 views)
Biochem Bioph Res Co (ISSN: 0006-291x), 2017 Sep 15; N/D: N/D-N/D.
Impact Factor: 2.559
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Platella C, Guida S, Bonmassar L, Aquino A, Bonmassar E, Ravagnan G, Montesarchio D, Roviello GN, Musumeci D, Fuggetta MP
* Antitumour activity of resveratrol on human melanoma cells: a possible mechanism related to its interaction with malignant cell telomerase (395 views)
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Impact Factor: 4.28
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Monti S, Cocozza S, Borrelli P, Straub S, Ladd ME, Salvatore M, Tedeschi E, Palma G
* MAVEN: An Algorithm for Multi-Parametric Automated Segmentation of Brain Veins from Gradient Echo Acquisitions (298 views) (PDF 201 views)
Ieee T Med Imaging (ISSN: 0278-0062), 2017; 36(5): 1054-1065.
Impact Factor: 6.131
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Roviello GN, Vicidomini C, Costanzo V, Roviello V
* Nucleic acid binding and other biomedical properties of artificial oligolysines (347 views)
International Journal Of Nanomedicine, 2016 Nov; 11: 5897-5904.
Impact Factor: 4.32
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Sholokh M, Improta R, Mori M, Sharma R, Kenfack C, Shin D, Voltz K, Stote RH, Zaporozhets OA, Botta M, Tor Y, Mely Y
* Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels (409 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2016 Jun 8; N/D: N/D-N/D.
Impact Factor: 11.994
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Roviello GN, Musumeci D
* Synthetic approaches to nucleopeptides containing all the four nucleobases, and nucleic acid-binding studies on a mixed-sequence nucleo-oligolysine (582 views)
Rsc Adv (ISSN: 2046-2069, 2046-2069electronic), 2016 Jun; 6: 63578-63585.
Impact Factor: 3.108
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Roviello GN, Roviello V, Autiero I, Saviano M
* Solid phase synthesis of TyrT, a thymine-tyrosine conjugate with poly(A) RNA-binding ability (654 views)
Rsc Adv (ISSN: 2046-2069, 2046-2069electronic, 2046-2069linking), 2016 Mar 15; 6(33): 27607-27613.
Impact Factor: 3.108
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Mainenti PP, Pizzuti LM, Segreto S, Comerci M, Fronzo SD, Romano F, Crisci V, Smaldone M, Laccetti E, Storto G, Alfano B, Maurea S, Salvatore M, Pace L
* Diffusion volume (DV) measurement in endometrial and cervical cancer: A new MRI parameter in the evaluation of the tumor grading and the risk classification (1064 views) (PDF 254 views)
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Impact Factor: 2.462
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Improta R, Santoro F, Blancafort L
* Quantum Mechanical Studies on the Photophysics and the Photochemistry of Nucleic Acids and Nucleobases (1604 views)
Chem Rev (ISSN: 0009-2665), 2016; 116(6): 3540-3593.
Impact Factor: 47.928
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Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (550 views)
Rsc Adv (ISSN: 2046-2069, 2046-2069electronic), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
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Ringhieri P, Avitabile C, Saviano M, Morelli G, Romanelli A, Accardo A
* The influence of liposomal formulation on the incorporation and retention of PNA oligomers (391 views)
Colloid Surface B (ISSN: 0927-7765), 2016; 145: 462-469.
Impact Factor: 3.887
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Autiero I, Saviano M, Langella E
* Conformational studies of chiral D-Lys-PNA and achiral PNA system in binding with DNA or RNA through a molecular dynamics approach (625 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015 Feb 16; 91: 109-117.
Impact Factor: 3.902
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (573 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2015; 26(8): 1533-1541.
Impact Factor: 4.5
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Roviello GN, Musumeci D, Roviello V, Pirtskhalava M, Egoyan A, Mirtskhulava M
* Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure (487 views)
Beilstein J Nanotech (ISSN: 2190-4286), 2015; 6(1): 1338-1347.
Impact Factor: 2.778
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Fahleson T, Kauczor J, Norman P, Santoro F, Improta R, Coriani S
* TD-DFT investigation of the magnetic circular dichroism spectra of some purine and pyrimidine bases of nucleic acids (620 views)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic, 1089-5639linking), 2015; 119(21): 5476-5489.
Impact Factor: 2.883
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Notomista E, Falanga A, Fusco S, Pirone L, Zanfardino A, Galdiero S, Varcamonti M, Pedone E, Contursi P
* The identification of a novel Sulfolobus islandicus CAMP-like peptide points to archaeal microorganisms as cell factories for the production of antimicrobial molecules (1055 views)
Microb Cell Fact (ISSN: 1475-2859), 2015; 14(1): N/D-N/D.
Impact Factor: 3.744
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Conson M, Cella L, Pacelli R, Comerci M, Liuzzi R, Salvatore M, Quarantelli M
* Automated delineation of brain structures in patients undergoing radiotherapy for primary brain tumors: From atlas to dose-volume histograms (1077 views) (PDF 395 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 0167-8140linking), 2014 Sep; 112(3): 326-331.
Impact Factor: 4.363
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Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (613 views)
Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
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Autiero I, Saviano M, Langella E
* Molecular Dynamics Simulations Of Pna-Pna And Pna-Dna Duplexes By The Use Of New Parameters Implemented In The Gromacs Package: A Conformational And Dynamics Study (1006 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2014 Feb 7; 16(5): 1868-1874.
Impact Factor: 4.493
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Roviello GN, Musumeci D, D'Alessandro C, Pedone C
* Binding ability of a thymine-functionalized oligolysine towards nucleic acids (400 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 997-1002.
Impact Factor: 2.793
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Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F
* A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex (780 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2014 Feb; 70(2): 362-370.
Impact Factor: 7.232
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Pica A, Russo Krauss I, Merlino A, Nagatoishi S, Sugimoto N, Sica F
* Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer (607 views)
Febs Journal (ISSN: 1742-464x), 2013 Dec; 280(24): 6581-6588.
Impact Factor: 3.986
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Russo Krauss I, Pica A, Merlino A, Mazzarella L, Sica F
* Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer (1181 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Dec; 69(12): 2403-2411.
Impact Factor: 7.232
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Paladino A, Zangi R
Propensities for loop structures of RNA & DNA backbones (136 views)
Biophys Chem (ISSN: 0301-4622linking), 2013 Oct; 180-181: 110-118.
Impact Factor:
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Roviello GN, Musumeci D, D'Alessandro C, Pedone C
* Synthesis of a thymine-functionalized nucleoamino acid for the solid phase assembly of cationic nucleopeptides (599 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2013 Oct; 45(4): 779-784.
Impact Factor: 3.653
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Russo Krauss I, Merlino A, Vergara A, Sica F
* An overview of biological macromolecule crystallization (1277 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 May 31; 14(6): 11643-11691.
Impact Factor: 2.339
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Zanoli LM, Licciardello M, D'Agata R, Lantano C, Calabretta A, Corradini R, Marchelli R, Spoto G
* Peptide nucleic acid molecular beacons for the detection of PCR amplicons in droplet-based microfluidic devices (501 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 615-624.
Impact Factor: 3.578
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D'Agata R, Spoto G
* Surface plasmon resonance imaging for nucleic acid detection (426 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 573-584.
Impact Factor: 3.578
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (554 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2013; 452(3): 545-557.
Impact Factor: 4.779
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (542 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
Impact Factor: 3.914
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (614 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Banyasz A, Douki T, Improta R, Gustavsson T, Onidas D, Vaya I, Perron M, Markovitsi D
* Electronic excited states responsible for dimer formation upon UV absorption directly by thymine strands: Joint experimental and theoretical study (424 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Sep 12; 134(36): 14834-14845.
Impact Factor: 10.677
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Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
* Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (606 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 7; 7(5): e35774-e35774.
Impact Factor: 3.73
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (677 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Avitabile C, Saviano M, D'Andrea LD, Bianchi N, Fabbri E, Brognara E, Gambari R, Romanelli A
* Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation (882 views)
Artif Dna Pna Xnaartificial Dna Pna & Xna (ISSN: 1949-9096, 1949-0968, 1949-095x), 2012 Apr; 3(2): 88-96.
Impact Factor: 0
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Improta R, Barone V
* Interplay between "neutral" and "charge-transfer" excimers rules the excited state decay in adenine-rich polynucleotides (744 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2011 Dec 9; 50(50): 12016-12019.
Impact Factor: 13.455
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications (607 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2011 Sep 30; 415(1-2): 206-210.
Impact Factor: 3.35
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Nucleobase-containing peptides: a spectroscopic study of their properties and nucleic acids recognition ability (461 views)
Eur Biophys J (ISSN: 0175-7571, 1432-1017, 0175-7571linking), 2011 Sep; 40: N/D-N/D.
Impact Factor: 2.139
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Scognamiglio PL, Doti N, Grieco P, Pedone C, Ruvo M, Marasco D
* Discovery Of Small Peptide Antagonists Of Ped/Pea15-D4alpha Interaction From Simplified Combinatorial Libraries (594 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 May; 77(5): 319-327.
Impact Factor: 2.282
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Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (621 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
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Roviello GN, Ricci A, Bucci EM, Pedone C
* Synthesis, biological evaluation and supramolecular assembly of novel analogues of peptidyl nucleosides (1680 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1773-1778.
Impact Factor: 3.534
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Evidences for supramolecular organization of nucleopeptides: Synthesis, spectroscopic and biological studies of a novel dithymine l-serine tetrapeptide (719 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 Apr; 7(4): 1073-1080.
Impact Factor: 3.534
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D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (484 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
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Moccia M, Roviello GN, Bucci EM, Pedone C, Saviano M
* Synthesis of a l-lysine-based alternate alpha, epsilon-peptide: A novel linear polycation with nucleic acids-binding ability (587 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2010 Sep 15; 397(1-2): 179-183.
Impact Factor: 3.607
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (412 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
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Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (510 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
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Russo Krauss I, Merlino A, Randazzo A, Mazzarella L, Sica F
* Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer (507 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309, 1532-2335electronic), 2010 Aug 1; 66(Pt8): 961-963.
Impact Factor: 0.563
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Avitabile C, Moggio L, D'Andrea LD, Pedone C, Romanelli A
* Development of an efficient and low-cost protocol for the manual PNA synthesis by Fmoc chemistry (633 views)
Tetrahedron Lett (ISSN: 0040-4039), 2010 Jul 21; 51(29): 3716-3718.
Impact Factor: 2.618
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Gustavsson T, Improta R, Markovitsi D
DNA/RNA: Building blocks of life under UV irradiation (367 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2010 Jul 1; 1(13): 2025-2030.
Impact Factor: 6.687
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Roviello GN, Benedetti E, Pedone C, Bucci EM
* Nucleobase-containing peptides: An overview of their characteristic features and applications (963 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jun; 39(1): 45-57.
Impact Factor: 4.106
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA (590 views)
Lect Notes Electr Eng, 2010 May 15; 91LNEE: 485-488.
Impact Factor: 0
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (640 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
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Pensato S, Renda M, Leccia F, Saviano M, D'Andrea LD, Pedone C, Pedone PV, Romanelli A
* PNA zipper as a dimerization tool: development of a bZip mimic (698 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 May; 93(5): 434-441.
Impact Factor: 2.572
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Roviello GN, Gröschel S, Pedone C, Diederichsen U
* Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras (1111 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2010 May; 38(5): 1301-1309.
Impact Factor: 4.106
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Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (544 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
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Roviello GN, Musumeci D, De Cristofaro A, Capasso D, Di Gaetano S, Bucci EM, Pedone C
* Alternate dab-aegPNAs: synthesis, nucleic acid binding studies and biological activity (586 views)
Mol Biosyst (ISSN: 1742-2051, 1742-206x, 1742-2051electronic), 2010 Jan; 6(1): 199-205.
Impact Factor: 3.825
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Orsi S, De Capua A, Guarnieri D, Marasco D, Netti PA
* Cell recruitment and transfection in gene activated collagen matrix (479 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2010 Jan; 31(3): 570-576.
Impact Factor: 7.883
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Roviello GN, Musumeci D, Pedone C, Bucci EM
* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (669 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
Impact Factor: 4.106
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D'Agata R, Breveglieri G, Zanoli L, Borgatti M, Spoto G, Gambari R
* Surface Plasmon Resonance Imaging (SPR-I), peptide nucleic acid (PNA) probes and nanoparticle-enhancement for PCR-free ultrasensitive detection of beta-thalassemia mutations in human genomic DNA (335 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2010; 26: N/D-N/D.
Impact Factor: 1.814
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Improta R, Santoro F, Barone V, Lami A
* Vibronic model for the quantum dynamical study of the competition between bright and charge-transfer excited states in single-strand polynucleotides: the adenine dimer case (354 views)
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic, 1089-5639linking), 2009 Dec 31; 113(52): 15346-15354.
Impact Factor: 2.899
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Ruggiero A, Di Maro A, Severino V, Chambery A, Berisio R
* Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage (489 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1135-1142.
Impact Factor: 2.605
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (1173 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
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Grasso G, D'Agata R, Zanoli L, Spoto G
* Microfluidic networks for surface plasmon resonance imaging real-time kinetics experiments (319 views)
Microchemical Journal (ISSN: 0026-265x), 2009 Sep; 93(1): 82-86.
Impact Factor: 2.579
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Grasso G, Bush AI, D'Agata R, Rizzarelli E, Spoto G
* Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme (736 views)
Eur Biophys J (ISSN: 1432-1017, 0175-7571, 0175-7571linking), 2009 Apr; 38(4): 407-414.
Impact Factor: 2.437
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (544 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (700 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Santoro F, Barone V, Improta R
* The Excited States Decay Of The A-T Dna: A Pcm/Td-Dft Study In Aqueous Solution Of The (9-Methyl-Adenine) 2 (1-Methyl-Thymine) 2 Stacked Tetramer (320 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2009; 131(42): 15232-15245.
Impact Factor: 8.58
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (683 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Merlino A, Varriale S, Coscia MR, Mazzarella L, Oreste U
* Structure and dimerization of the teleost transmembrane immunoglobulin region (561 views)
Journal Of Molecular Graphics & Modelling (ISSN: 1093-3263), 2008 Oct; 27(3): 401-407.
Impact Factor: 2.347
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Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (426 views)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
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D'Agata R, Corradini R, Grasso G, Marchelli R, Spoto G
* Ultrasensitive detection of DNA by PNA and nanoparticle-enhanced surface plasmon resonance imaging (479 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2008 Sep 1; 9(13): 2067-2070.
Impact Factor: 3.322
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Improta R, Barone V
The excited states of adenine and thymine nucleoside and nucleotide in aqueous solution: A comparative study by time-dependent DFT calculations (327 views)
Theor Chem Acc (ISSN: 1432-881x), 2008 Jul; 120(4-6): 491-497.
Impact Factor: 2.37
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Santoro F, Barone V, Improta R
* Can TD-DFT calculations accurately describe the excited states behavior of stacked nucleobases? The cytosine dimer as a test case (404 views)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic, 0192-8651linking), 2008 Apr 30; 29(6): 957-964.
Impact Factor: 3.39
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Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (503 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
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Pensato S, D'Andrea LD, Pedone C, Romanelli A
* New synthetic route to gamma-mercaptomethyl PNA monomers (483 views)
Synth Commun Synthetic Communications (ISSN: 0039-7911), 2008; 38(15): 2499-2506.
Impact Factor: 0.981
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Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (448 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
Impact Factor: 0.1
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (521 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Zanoli L, Dagata R, Spoto G
* Surface plasmon-based optical detection of DNA peptide nucleic acids (389 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 165-174.
Impact Factor: 0.1
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Tedeschi G, Dinacci D, Lavorgna L, Prinster A, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Servillo G, Bresciamorra V, Orefice G, Paciello M, Brunetti A, Paolillo A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone I, Salvatore M, Bonavita V, Alfano B
* Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability (674 views) (PDF 273 views)
J Neurol Sci (ISSN: 0022-510x, 0022-510xlinking), 2007 Dec 15; 263(1-2): 15-19.
Impact Factor: 2.315
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Pensato S, Saviano M, Romanelli A
* New peptide nucleic acid analogues: synthesis and applications (679 views)
Expert Opinion On Biological Therapy (ISSN: 1471-2598), 2007 Sep; 7(8): 1219-1232.
Impact Factor: 2.815
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, Pedone C
* Dabpna: Design, Synthesis And Nucleic Acids Binding Studies (483 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1307-1310.
Impact Factor: 0.723
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Santoro F, Barone V, Improta R
* Influence of base stacking on excited-state behavior of polyadenine in water, based on time-dependent density functional calculations (751 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007; 104(24): 9931-9936.
Impact Factor: 9.598
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (325 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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Moccia M, Musumeci D, Valente M, Roviello GN, Sapio R, Pedone C, Bucci EM
* Thermodynamic studies on PNA and PNA/DNA dendrimer formation (333 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1173-1176.
Impact Factor: 0.723
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Santoro F, Gustavsson T, Lami S, Barone V, Improta R
* Towards the understanding of the excited state dynamics of nucleic acids: Solvent and stacking effect on the photophysical behavior of nucleobases (351 views)
Aip Conf Proc (ISSN: 0094-243x), 2007; 963(2): 631-634.
Impact Factor: 0
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Santoro F, Barone V, Gustavsson T, Improta R
* Solvent effect on the singlet excited-state lifetimes of nucleic acid bases: A computational study of 5-fluorouracil and uracil in acetonitrile and water (1041 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Dec 20; 128(50): 16312-16322.
Impact Factor: 7.696
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Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (610 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
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Musumeci D, Valente M, Capasso D, Palumbo R, Gorlach M, Schmidtke M, Zell R, Roviello GN, Sapio R, Pedone C, Bucci EM
* A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis (551 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Mar; 12(3): 161-170.
Impact Factor: 1.801
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Bernini E De Nuccio R, Brescia F, Minardo A, Zeni L, Sarro PM, Palumbo R, Scarf MR
* Development and characterization of an integrated silicon micro flow cytometer (409 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2006; 386(5): 1267-1272.
Impact Factor: 2.591
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (569 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (489 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
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Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A
* A crevice adjoining the ribosome tunnel: Hints for cotranslational folding (469 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Jun 13; 579(15): 3207-3213.
Impact Factor: 3.415
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (513 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (559 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
Impact Factor: 3.3
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Improta R, Barone V
* Absorption and fluorescence spectra of uracil in the gas phase and in aqueous solution: A TD-DFT quantum mechanical study (422 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Nov 10; 126(44): 14320-14321.
Impact Factor: 6.903
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (683 views)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Berisio R, Granata V, Vitagliano L, Zagari A
* Imino acids and collagen triple helix stability: Characterization of collagen-like polypeptides containing Hyp-Hyp-Gly sequence repeats (555 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Sep 22; 126(37): 11402-11403.
Impact Factor: 6.903
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Mischiati C, Sereni A, Finotti A, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Pedone C, Borgatti M, Gambari R
* Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity (514 views)
Journal Of Biomedical Science (ISSN: 1021-7770), 2004 Sep; 11(5): 697-704.
Impact Factor: 1.567
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (371 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Improta R, Barone V
* Interplay of electronic, environmental, and vibrational effects in determining the hyperfine coupling constants of organic free radicals (339 views)
Chem Rev (ISSN: 0009-2665), 2004 Mar; 104(3): 1231-1253.
Impact Factor: 20.233
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (451 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Musumeci D, Roviello GN, Valente M, Sapio R, Pedone C, Bucci EM
* New synthesis of PNA-3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras (494 views)
Biopolymers, 2004; 76(6): 535-542.
Impact Factor: 2.248
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Ohlenschlager O, Wohnert J, Bucci E, Seitz S, Hafner S, Ramachandran R, Zell R, Gorlach M
* The Structure of the Stemloop D Subdomain of Coxsackievirus B3 Cloverleaf RNA and Its Interaction with the Proteinase 3C (771 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2004; 12(2): 237-248.
Impact Factor: 5.185
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Menchise V, De Simone G, Tedeschi T, Corradini R, Sforza S, Marchelli R, Capasso D, Saviano M, Pedone C
* Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a D-lysine-based chiral PNA-DNA duplex (2411 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2003 Oct 14; 100(21): 12021-12026.
Impact Factor: 10.272
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Bashan A, Zarivach R, Schluenzen F, Agmon I, Harms J, Auerbach T, Baram D, Berisio R, Bartels H, Hansen HAS, Fucini P, Wilson D, Peretz M, Kessler M, Yonath A
* Ribosomal crystallography: Peptide bond formation and its inhibition (641 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003 Sep; 70(1): 19-41.
Impact Factor: 2.733
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Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, Mischiati C, Gambari R
* Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites (912 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2003 Feb 28; 278(9): 7500-7509.
Impact Factor: 6.482
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Bashan A, Agmon I, Zarivach R, Schluenzen F, Harms J, Berisio R, Bartels H, Franceschi F, Auerbach T, Hansen HAS, Kossoy E, Kessler M, Yonath A
* Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression (541 views)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2003 Jan; 11(1): 91-102.
Impact Factor: 16.835
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (530 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Gambari R, Borgatti M, Romanelli A, Capasso D, Saviano M, Bianchi N, Lampronti I, Mischiati C, Pedone C
* Transcription factor decoy (TFD) activity of peptide nucleic acids (PNA)-DNA chimeras (372 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2003; 12(Supplement1): N/D-N/D.
Impact Factor: 1.94
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (545 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Berisio R, Vitagliano L, Mazzarella L, Zagari A
* Recent progress on collagen triple helix structure, stability and assembly (662 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2002 Apr; 9(2): 107-116.
Impact Factor: 0.622
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Menchise V, De Simone G, Corradini R, Sforza S, Sorrentino N, Romanelli A, Saviano M, Pedone C
* Crystallization and preliminary X-ray diffraction studies of a D-lysine-based chiral PNA-DNA duplex (422 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2002 Mar; 58(3): 553-555.
Impact Factor: 1.76
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (557 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites (576 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 2.849
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (509 views)
Eur J Biochem (ISSN: 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 4.779
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (690 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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Esposito L, Vitagliano L, Zagari A, Mazzarella L
Experimental evidence for the correlation of bond distances in peptide groups detected in ultrahigh-resolution protein structures (384 views)
Protein Eng (ISSN: 0269-2139, 0269-2139print, 0269-2139linking), 2000 Dec; 13(12): 825-828.
Impact Factor: 2.442
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Lombardi A, Marasco D, Maglio O, Di Costanzo L, Nasti F, Pavone V
Miniaturized metalloproteins: Application to iron-sulfur proteins (834 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2000 Oct 24; 97(22): 11922-11927.
Impact Factor: 10.789
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Kramer RZ, Vitagliano L, Bella J, Berisio R, Mazzarella L, Brodsky B, Zagari A, Berman HM
X-ray crystallographic determination of a collagen-like peptide with the repeating sequence (Pro-Pro-Gly) (612 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1998 Jul 24; 280(4): 623-638.
Impact Factor: 5.803
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Bustamante C, Gurrieri S, Pasternack RF, Purrello R, Rizzarelli E
Interaction of water-soluble porphyrins with single- and double-stranded polyribonucleotides (430 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Sep; 34(8): 1099-1104.
Impact Factor: 2.425
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Salvati AM, d'Onofrio G, Berti P, Cappabianca MP, Marsili G, De Philippis C, Cossa L, Quarantelli M, Zini G, Mango G
An assessment of the operating characteristics of Coulter Counter model S-Plus STKR (666 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1991 Mar; 76(2): 94-103.
Impact Factor: 2.56
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Montanaro V, Casamassimi A, D'Urso M, Yoon JY, Freije W, Schlessinger D, Muenke M, Nussbaum RL, Saccone S, Maugeri S
In Situ Hybridization To Cytogenetic Bands Of Yeast Artificial Chromosomes Covering 50% Of Human Xq24-Xq28 Dna (431 views)
Am J Hum Genet, 1991 Feb; 48(2): 183-194.
Impact Factor: 0
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Gurrieri S, Rizzarelli E, Beach D, Bustamante C
Imaging of kinked configurations of DNA molecules undergoing orthogonal field alternating gel electrophoresis by fluorescence microscopy (670 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 1990 Apr 3; 29(13): 3396-3401.
Impact Factor: 4.572
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152 Records (145 excluding Abstracts).
Total impact factor: 672.583 (660.459 excluding Abstracts).
Total 5 year impact factor: 716.536 (700.809 excluding Abstracts).
Total impact factor: 672.583 (660.459 excluding Abstracts).
Total 5 year impact factor: 716.536 (700.809 excluding Abstracts).
480 views. Last view on Monday 16 September 2024, 21:52:24
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