Peptides targeting angiogenesis related growth factor receptors (14494 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T, Review,
Impact factor: 4.414, 5-year impact factor: 3.988
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-69249113838&partnerID=40&md5=10fae5d9f0525db438ec669e564d7f35
Keywords: Angiogenesis, Fgf, Growth Factor, Pdgf, Peptide, Vegf, Angiogenesis Inhibitor, Angiogenic Factor, Becaplermin, Bevacizumab, Fibroblast Growth Factor, Fibroblast Growth Factor 1 Antagonist, Fibroblast Growth Factor 2 Antagonist, Fibroblast Growth Factor 5 Antagonist, Fibroblast Growth Factor Receptor, Matrix Metalloproteinase, Platelet Derived Growth Factor, Platelet Derived Growth Factor Bb, Platelet Derived Growth Factor Receptor, Protein Inhibitor, Proteoheparan Sulfate, Recombinant Platelet Derived Growth Factor Bb, Unclassified Drug, Vasculotropin, Vasculotropin Receptor 1, Cell Interaction, Cell Migration, Cell Proliferation, Gene Expression Regulation, Hair Loss, Nonhuman, Priority Journal, Protein Expression, Protein Function, Protein Phosphorylation, Protein Protein Interaction, Protein Structure, Receptor Binding, Review, Structure Analysis, Animals, Intercellular Signaling Peptides And Proteins, Neovascularization, Pathologic, Platelet-Derived Growth Factor, Signal Transduction, Vascular Endothelial Growth Factor A,
Affiliations:
*** IBB - CNR ***
Dipartimento delle Scienze Biologiche, Facolta di Scienze Biotecnologiche, Universita di Napoli Federico II, via Mezzocannone 16, 80134 Napoli, Italy. ldandrea@unina.it
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Napoli, Italy
References:
Hanahan, D., Folkman, J., Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis (1996) Cell, 86, pp. 353-36
Bergers, G., Benjamin, L.E., Tumorigenesis and the angiogenic switch (2003) Nat Rev Cancer, 3, pp. 401-410
Adams, R.H., Alitalo, K., Molecular regulation of angiogenesis and lymphangiogenesis (2007) Nat Rev Mol Cell Biol, 8, pp. 464-478
Carmeliet, P., Jain, R.K., Angiogenesis in cancer and other diseases (2000) Nature, 407, pp. 249-257
Folkman, J., Angiogenesis in cancer, vascular, rheumatoid and other disease (1995) Nat Med, 1, pp. 27-31
Carmeliet, P., Angiogenesis in life, disease and medicine (2005) Nature, 438, pp. 932-936
Ferrara, N., Kerbel, R.S., Angiogenesis as a therapeutic target (2005) Nature, 438, pp. 967-974
Bouis, D., Kusumanto, Y., Meijer, C., Mulder, N.H., Hospers, G.A., A review on pro- and anti-angiogenic factors as targets of clinical intervention (2006) Pharmacol Res, 53, pp. 89-103
Yancopoulos, G.D., Davis, S., Gale, N.W., Rudge, J.S., Wiegand, S.J., Holash, J., Vascular-specific growth factors and blood vessel formation (2000) Nature, 407, pp. 242-248
Rajkumar, T., Growth factoprs and growth factor receptors in cancer (2001) Current Science, 81, pp. 535-241
Heppeler, A., Froidevaux, S., Eberle, A.N., Maecke, H.R., Receptor targeting for tumor localisation and therapy with radiopeptides (2000) Curr Med Chem, 7, pp. 971-994
Okarvi, S.M., Peptide-based radiopharmaceuticals: Future tools for diagnostic imaging of cancers and other diseases (2004) Med Res Rev, 24, pp. 357-397
Ruegg, C., Hasmim, M., Lejeune, F.J., Alghisi, G.C., Antiangiogenic peptides and proteins: From experimental tools to clinical drugs (2006) Biochim Biophys Acta, 1765, pp. 155-177
D'Andrea, L.D., Del Gatto, A., Pedone, C., Benedetti, E., Peptide-based molecules in angiogenesis (2006) Chem Biol Drug Des, 67, pp. 115-126
Dings, R.P., Nesmelova, I., Griffioen, A.W., Mayo, K.H., Discovery and development of anti-angiogenic peptides: A structural link (2003) Angiogenesis, 6, pp. 83-91
Sulochana, K.N., Ge, R., Developing antiangiogenic peptide drugs for angiogenesis-related diseases (2007) Curr Pharm Des, 13, pp. 2074-2086
Bouma-ter Steege, J.C., Mayo, K.H., Griffioen, A.W., Angiostatic proteins and peptides (2001) Crit Rev Eukaryot Gene Expr, 11, pp. 319-334
Folkman, J., Merler, E., Abernathy, C., Williams, G., Isolation of a tumor factor responsible for angiogenesis (1971) J Exp Med, 133, pp. 275-288
Abraham, J.A., Whang, J.L., Tumolo, A., Mergia, A., Fiddes, J.C., Human basic fibroblast growth factor: Nucleotide sequence, genomic organization, and expression in mammalian cells (1986) Cold Spring Harb Symp Quant Biol, 51 (PART 1), pp. 657-668
Abraham, J.A., Mergia, A., Whang, J.L., Tumolo, A., Friedman, J., Hjerrild, K.A., Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor (1986) Science, 233, pp. 545-548
Powers, C.J., McLeskey, S.W., Wellstein, A., Fibroblast growth factors, their receptors and signaling (2000) Endocr Relat Cancer, 7, pp. 165-197
Ago, H., Kitagawa, Y., Fujishima, A., Matsuura, Y., Katsube, Y., Crystal structure of basic fibroblast growth factor at 1.6 A resolution (1991) J Biochem, 110, pp. 360-363
Eriksson, A.E., Cousens, L.S., Weaver, L.H., Matthews, B.W., Three-dimensional structure of human basic fibroblast growth factor (1991) Proc Natl Acad Sci USA, 88, pp. 3441-3445
Zhu, X., Komiya, H., Chirino, A., Faham, S., Fox, G.M., Arakawa, T., Three-dimensional structures of acidic and basic fibroblast growth factors (1991) Science, 251, pp. 90-93
Zhang, J.D., Cousens, L.S., Barr, P.J., Sprang, S.R., Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta (1991) Proc Natl Acad Sci USA, 88, pp. 3446-3450
Reuss, B., von Bohlen, Halbach, O., Fibroblast growth factors and their receptors in the central nervous system (2003) Cell Tissue Res, 313, pp. 139-157
Ornitz DM, Itoh N. Fibroblast growth factors. Genome Biol 2001
2: reviews3005.1-3005.12Klagsbrun, M., Baird, A., A dual receptor system is required for basic fibroblast growth factor activity (1991) Cell, 67, pp. 229-231
Saksela, O., Moscatelli, D., Sommer, A., Rifkin, D.B., Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation (1988) J Cell Biol, 107, pp. 743-751
Turnbull, J.E., Gallagher, J.T., Heparan sulphate: Functional role as a modulator of fibroblast growth factor activity (1993) Biochem Soc Trans, 21, pp. 477-482
David, G., Integral membrane heparan sulfate proteoglycans (1993) Faseb J, 7, pp. 1023-1030
Ornitz, D.M., Leder, P., Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3 (1992) J Biol Chem, 267, pp. 16305-16311
Mansukhani, A., Dell'Era, P., Moscatelli, D., Kornbluth, S., Hanafusa, H., Basilico, C., Characterization of the murine BEK fibroblast growth factor (FGF) receptor: Activation by three members of the FGF family and requirement for heparin (1992) Proc Natl Acad Sci USA, 89, pp. 3305-3309
Yayon, A., Klagsbrun, M., Esko, J.D., Leder, P., Ornitz, D.M., Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor (1991) Cell, 64, pp. 841-848
Rapraeger, A.C., Krufka, A., Olwin, B.B., Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation (1991) Science, 252, pp. 1705-1708
Chaffer, C.L., Dopheide, B., Savagner, P., Thompson, E.W., Williams, E.D., Aberrant fibroblast growth factor receptor signaling in bladder and other cancers (2007) Differentiation, 75, pp. 831-842
Lee, P.L., Johnson, D.E., Cousens, L.S., Fried, V.A., Williams, L.T., Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor (1989) Science, 245, pp. 57-60
Reid, H.H., Wilks, A.F., Bernard, O., Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain (1990) Proc Natl Acad Sci USA, 87, pp. 1596-1600
Safran, A., Avivi, A., Orr-Urtereger, A., Neufeld, G., Lonai, P., Givol, D., The murine flg gene encodes a receptor for fibroblast growth factor (1990) Oncogene, 5, pp. 635-643
Dionne, C.A., Crumley, G., Bellot, F., Kaplow, J.M., Searfoss, G., Ruta, M., Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors (1990) EMBO J, 9, pp. 2685-2692
Keegan, K., Johnson, D.E., Williams, L.T., Hayman, M.J., Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3 (1991) Proc Natl Acad Sci USA, 88, pp. 1095-1099
Partanen, J., Makela, T.P., Eerola, E., Korhonen, J., Hirvonen, H., Claesson-Welsh, L., FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern (1991) EMBO J, 10, pp. 1347-1354
Stark, K.L., McMahon, J.A., McMahon, A.P., FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse (1991) Development, 113, pp. 641-651
Zhang, X., Ibrahimi, O.A., Olsen, S.K., Umemori, H., Mohammadi, M., Ornitz, D.M., Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family (2006) J Biol Chem, 281, pp. 15694-15700
Stauber, D.J., DiGabriele, A.D., Hendrickson, W.A., Structural interactions of fibroblast growth factor receptor with its ligands (2000) Proc Natl Acad Sci USA, 97, pp. 49-54
Venkataraman, G., Shriver, Z., Davis, J.C., Sasisekharan, R., Fibroblast growth factors 1 and 2 are distinct in oligomerization in the presence of heparin-like glycosaminoglycans (1999) Proc Natl Acad Sci USA, 96, pp. 1892-1897
Zhan, X., Plourde, C., Hu, X., Friesel, R., Maciag, T., Association of fibroblast growth factor receptor-1 with c-Src correlates with association between c-Src and cortactin (1994) J Biol Chem, 269, pp. 20221-20224
Cross, M.J., Claesson-Welsh, L., FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition (2001) Trends Pharmacol Sci, 22, pp. 201-207
Cross, M.J., Hodgkin, M.N., Roberts, S., Landgren, E., Wakelam, M.J., Claesson-Welsh, L., Tyrosine 766 in the fibroblast growth factor receptor 1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells (2000) J Cell Sci, 113 (PART 4), pp. 643-651
Raffioni, S., Thomas, D., Foehr, E.D., Thompson, L.M., Bradshaw, R.A., Comparison of the intracellular signaling responses by three chimeric fibroblast growth factor receptors in PC12 cells (1999) Proc Natl Acad Sci USA, 96, pp. 7178-7183
Presta, M., Dell'Era, P., Mitola, S., Moroni, E., Ronca, R., Rusnati, M., Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis (2005) Cytokine Growth Factor Rev, 16, pp. 159-178
Rusnati, M., Presta, M., Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies (2007) Curr Pharm Des, 13, pp. 2025-2044
Mignatti, P., Rifkin, D.B., Nonenzymatic interactions between proteinases and the cell surface: Novel roles in normal and malignant cell physiology (2000) Adv Cancer Res, 78, pp. 103-157
Stokes, C.L., Rupnick, M.A., Williams, S.K., Lauffenburger, D.A., Chemotaxis of human microvessel endothelial cells in response to acidic fibroblast growth factor (1990) Lab Invest, 63, pp. 657-668
Terranova, V.P., DiFlorio, R., Lyall, R.M., Hic, S., Friesel, R., Maciag, T., Human endothelial cells are chemotactic to endothelial cell growth factor and heparin (1985) J Cell Biol, 101, pp. 2330-2334
Mattila, M.M., Ruohola, J.K., Valve, E.M., Tasanen, M.J., Seppanen, J.A., Harkonen, P.L., FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells (2001) Oncogene, 20, pp. 2791-2804
Gillis, P., Savla, U., Volpert, O.V., Jimenez, B., Waters, C.M., Panos, R.J., Keratinocyte growth factor induces angiogenesis and protects endothelial barrier function (1999) J Cell Sci, 112 (PART 12), pp. 2049-2057
Klein, S., Giancotti, F.G., Presta, M., Albelda, S.M., Buck, C.A., Rifkin, D.B., Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells (1993) Mol Biol Cell, 4, pp. 973-982
Collo, G., Pepper, M.S., Endothelial cell integrin alpha5beta1 expression is modulated by cytokines and during migration in vitro (1999) J Cell Sci, 112 (PART 4), pp. 569-578
Sepp, N.T., Li, L.J., Lee, K.H., Brown, E.J., Caughman, S.W., Lawley, T.J., Basic fibroblast growth factor increases expression of the alpha v beta 3 integrin complex on human microvascular endothelial cells (1994) J Invest Dermatol, 103, pp. 295-299
Underwood, P.A., Bean, P.A., Gamble, J.R., Rate of endothelial expansion is controlled by cell:cEll adhesion (2002) Int J Biochem Cell Biol, 34, pp. 55-69
Zhou, L., Dosanjh, A., Chen, H., Karasek, M., Divergent effects of extracellular oxygen on the growth, morphology, and function of human skin microvascular endothelial cells (2000) J Cell Physiol, 182, pp. 134-140
Gualandris, A., Rusnati, M., Belleri, M., Nelli, E.E., Bastaki, M., Molinari-Tosatti, M.P., Basic fibroblast growth factor overexpression in endothelial cells: An autocrine mechanism for angiogenesis and angioproliferative diseases (1996) Cell Growth Differ, 7, pp. 147-160
Armstrong, E., Vainikka, S., Partanen, J., Korhonen, J., Alitalo, R., Expression of fibroblast growth factor receptors in human leukemia cells (1992) Cancer Res, 52, pp. 2004-2007
Allouche, M., Bayard, F., Clamens, S., Fillola, G., Sie, P., Amalric, F., Expression of basic fibroblast growth factor (bFGF) and FGF-receptors in human leukemic cells (1995) Leukemia, 9, pp. 77-86
Katoh, O., Hattori, Y., Sato, T., Kimura, A., Kuramoto, A., Sugimura, T., Expression of the heparin-binding growth factor receptor genes in human megakaryocytic leukemia cells (1992) Biochem Biophys Res Commun, 183, pp. 83-92
Liuzzo, J.P., Moscatelli, D., Human leukemia cell lines bind basic fibroblast growth factor (FGF) on FGF receptors and heparan sulfates: Downmodulation of FGF receptors by phorbol ester (1996) Blood, 87, pp. 245-255
Basilico, C., Moscatelli, D., The FGF family of growth factors and oncogenes (1992) Adv Cancer Res, 59, pp. 115-165
Hagedorn, M., Bikfalvi, A., Target molecules for anti-angiogenic therapy: From basic research to clinical trials (2000) Crit Rev Oncol Hematol, 34, pp. 89-110
Tille, J.C., Wood, J., Mandriota, S.J., Schnell, C., Ferrari, S., Mestan, J., Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth factor-induced angiogenesis in vivo and in vitro (2001) J Pharmacol Exp Ther, 299, pp. 1073-1085
Seghezzi, G., Patel, S., Ren, C.J., Gualandris, A., Pintucci, G., Robbins, E.S., Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: An autocrine mechanism contributing to angiogenesis (1998) J Cell Biol, 141, pp. 1659-1673
Lindahl, U., Lidholt, K., Spillmann, D., Kjellen, L., More to "heparin" than anticoagulation (1994) Thromb Res, 75, pp. 1-32
Iozzo, R.V., San Antonio, J.D., Heparan sulfate proteoglycans: Heavy hitters in the angiogenesis arena (2001) J Clin Invest, 108, pp. 349-355
Ribatti, D., Leali, D., Vacca, A., Giuliani, R., Gualandris, A., Roncali, L., In vivo angiogenic activity of urokinase: Role of endogenous fibroblast growth factor-2 (1999) J Cell Sci, 112 (PART 23), pp. 4213-4221
Presta, M., Maier, J.A., Rusnati, M., Ragnotti, G., Basic fibroblast growth factor is released from endothelial extracellular matrix in a biologically active form (1989) J Cell Physiol, 140, pp. 68-74
Simons, M., Horowitz, A., Syndecan-4-mediated signalling (2001) Cell Signal, 13, pp. 855-862
Rusnati, M., Urbinati, C., Presta, M., Internalization of basic fibroblast growth factor (bFGF) in cultured endothelial cells: Role of the low affinity heparin-like bFGF receptors (1993) J Cell Physiol, 154, pp. 152-161
Hsia, E., Richardson, T.P., Nugent, M.A., Nuclear localization of basic fibroblast growth factor is mediated by heparan sulfate proteoglycans through protein kinase C signaling (2003) J Cell Biochem, 88, pp. 1214-1225
Gajdusek, C.M., Carbon, S., Injury-induced release of basic fibroblast growth factor from bovine aortic endothelium (1989) J Cell Physiol, 139, pp. 570-579
Gloe, T., Sohn, H.Y., Meininger, G.A., Pohl, U., Shear stress-induced release of basic fibroblast growth factor from endothelial cells is mediated by matrix interaction via integrin alpha(v)beta3 (2002) J Biol Chem, 277, pp. 23453-23458
Hartnett, M.E., Garcia, C.M., D'Amore, P.A., Release of bFGF, an endothelial cell survival factor, by osmotic shock (1999) Invest Ophthalmol Vis Sci, 40, pp. 2945-2951
Pugh, C.W., Oxygen sensing in cancer (2003) Ann Med, 35, pp. 380-390
Kuwabara, K., Ogawa, S., Matsumoto, M., Koga, S., Clauss, M., Pinsky, D.J., Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells (1995) Proc Natl Acad Sci USA, 92, pp. 4606-4610
Li, J., Shworak, N.W., Simons, M., Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites (2002) J Cell Sci, 115, pp. 1951-1959
Ornitz, D.F., heparan sulfate and FGFRs: Complex interactions essential for development (2000) Bioessays, 22, pp. 108-112
Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M., Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity (2000) Cell, 101, pp. 413-424
Moy, F.J., Seddon, A.P., Bohlen, P., Powers, R., High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy (1996) Biochemistry, 35, pp. 13552-13561
Li, L.Y., Safran, M., Aviezer, D., Bohlen, P., Seddon, A.P., Yayon, A., Diminished heparin binding of a basic fibroblast growth factor mutant is associated with reduced receptor binding, mitogenesis, plasminogen activator induction, and in vitro angiogenesis (1994) Biochemistry, 33, pp. 10999-11007
Blaber, M., DiSalvo, J., Thomas, K.A., X-ray crystal structure of human acidic fibroblast growth factor (1996) Biochemistry, 35, pp. 2086-2094
Faham, S., Hileman, R.E., Fromm, J.R., Linhardt, R.J., Rees, D.C., Heparin structure and interactions with basic fibroblast growth factor (1996) Science, 271, pp. 1116-1120
DiGabriele, A.D., Lax, I., Chen, D.I., Svahn, C.M., Jaye, M., Schlessinger, J., Structure of a heparin-linked biologically active dimer of fibroblast growth factor (1998) Nature, 393, pp. 812-817
Plotnikov, A.N., Schlessinger, J., Hubbard, S.R., Mohammadi, M., Structural basis for FGF receptor dimerization and activation (1999) Cell, 98, pp. 641-650
Ornitz, D.M., Yayon, A., Flanagan, J.G., Svahn, C.M., Levi, E., Leder, P., Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells (1992) Mol Cell Biol, 12, pp. 240-247
Sudhalter, J., Folkman, J., Svahn, C.M., Bergendal, K., D'Amore, P.A., Importance of size, sulfation, and anticoagulant activity in the potentiation of acidic fibroblast growth factor by heparin (1989) J Biol Chem, 264, pp. 6892-6897
Schlessinger, J., Plotnikov, A.N., Ibrahimi, O.A., Eliseenkova, A.V., Yeh, B.K., Yayon, A., Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization (2000) Mol Cell, 6, pp. 743-750
Pellegrini, L., Burke, D.F., von Delft, F., Mulloy, B., Blundell, T.L., Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin (2000) Nature, 407, pp. 1029-1034
Kan, M., Wang, F., Xu, J., Crabb, J.W., Hou, J., McKeehan, W.L., An essential heparin-binding domain in the fibroblast growth factor receptor kinase (1993) Science, 259, pp. 1918-1921
Schubert, D., Ling, N., Baird, A., Multiple influences of a heparin-binding growth factor on neuronal development (1987) J Cell Biol, 104, pp. 635-643
Baird, A., Schubert, D., Ling, N., Guillemin, R., Receptor- and heparin-binding domains of basic fibroblast growth factor (1988) Proc Natl Acad Sci USA, 85, pp. 2324-2328
Ray, J., Baird, A., Gage, F.H., A 10-amino acid sequence of fibroblast growth factor 2 is sufficient for its mitogenic activity on neural progenitor cells (1997) Proc Natl Acad Sci USA, 94, pp. 7047-7052
Williams, E.J., Williams, G., Howell, F.V., Skaper, S.D., Walsh, F.S., Doherty, P., Identification of an N-cadherin motif that can interact with the fibroblast growth factor receptor and is required for axonal growth (2001) J Biol Chem, 276, pp. 43879-43886
Ito, C., Saitoh, Y., Fujita, Y., Yamazaki, Y., Imamura, T., Oka, S., Decapeptide with fibroblast growth factor (FGF)-5 partial sequence inhibits hair growth suppressing activity of FGF-5 (2003) J Cell Physiol, 197, pp. 272-283
Yayon, A., Aviezer, D., Safran, M., Gross, J.L., Heldman, Y., Cabilly, S., Isolation of peptides that inhibit binding of basic fibroblast growth factor to its receptor from a random phage-epitope library (1993) Proc Natl Acad Sci USA, 90, pp. 10643-10647
Terada, T., Mizobata, M., Kawakami, S., Yabe, Y., Yamashita, F., Hashida, M., Basic fibroblast growth factor-binding peptide as a novel targeting ligand of drug carrier to tumor cells (2006) J Drug Target, 14, pp. 536-545
Maruta, F., Parker, A.L., Fisher, K.D., Hallissey, M.T., Ismail, T., Rowlands, D.C., Identification of FGF receptor-binding peptides for cancer gene therapy (2002) Cancer Gene Ther, 9, pp. 543-552
Cosic, I., Drummond, A.E., Underwood, J.R., Hearn, M.T., In vitro inhibition of the actions of basic FGF by a novel 16 amino acid peptide (1994) Mol Cell Biochem, 130, pp. 1-9
McConnell, S.J., Thon, V.J., Spinella, D.G., Isolation of fibroblast growth factor receptor binding sequences using evolved phage display libraries (1999) Comb Chem High Throughput Screen, 2, pp. 155-163
Fan, H., Duan, Y., Zhou, H., Li, W., Li, F., Guo, L., Selection of peptide ligands binding to fibroblast growth factor receptor 1 (2002) IUBMB Life, 54, pp. 67-72
Oyama Jr., S., Miranda, M.T., Toma, I.N., Viviani, W., Gambarini, A.G., Mitogenic activity of peptides related to the sequence of human fibroblast growth factor-1 (1996) Biochem Mol Biol Int, 39, pp. 1237-1244
Kiyota, S., Franzoni, L., Nicastro, G., Benedetti, A., Oyama Jr., S., Viviani, W., Introduction of a chemical constraint in a short peptide derived from human acidic fibroblast growth factor elicits mitogenic structural determinants (2003) J Med Chem, 46, pp. 2325-2333
Tzeng, S.F., Deibler, G.E., DeVries, G.H., Myelin basic protein and myelin basic protein peptides induce the proliferation of Schwann cells via ganglioside GM1 and the FGF receptor (1999) Neurochem Res, 24, pp. 255-260
Li, S., Christensen, C., Kiselyov, V.V., Kohler, L.B., Bock, E., Berezin, V., Fibroblast growth factor-derived peptides: Functional agonists of the fibroblast growth factor receptor (2008) J Neurochem, 104, pp. 667-682
Anderson, A.A., Kendal, C.E., Garcia-Maya, M., Kenny, A.V., Morris-Triggs, S.A., Wu, T., A peptide from the first fibronectin domain of NCAM acts as an inverse agonist and stimulates FGF receptor activation, neurite outgrowth and survival (2005) J Neurochem, 95, pp. 570-583
Ballinger, M.D., Shyamala, V., Forrest, L.D., Deuter-Reinhard, M., Doyle, L.V., Wang, J.X., Semirational design of a potent, artificial agonist of fibroblast growth factor receptors (1999) Nat Biotechnol, 17, pp. 1199-1204
Kiselyov, V.V., Skladchikova, G., Hinsby, A.M., Jensen, P.H., Kulahin, N., Soroka, V., Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP (2003) Structure, 11, pp. 691-701
Neiiendam, J.L., Kohler, L.B., Christensen, C., Li, S., Pedersen, M.V., Ditlevsen, D.K., An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons (2004) J Neurochem, 91, pp. 920-935
Lin, X., Takahashi, K., Campion, S.L., Liu, Y., Gustavsen, G.G., Pena, L.A., Synthetic peptide F2A4-K-NS mimics fibroblast growth factor-2 in vitro and is angiogenic in vivo (2006) Int J Mol Med, 17, pp. 833-839
Lin, X., Pena, L.A., Zamora, P.O., Campion, S.L., Takahashi, K., Augmentation of demineralized bone matrix (DBM) mineralization by a synthetic growth factor mimetic (2006) J Orthop Res, 24, pp. 2051-2058
Ross, R., Glomset, J., Kariya, B., Harker, L., A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro (1974) Proc Natl Acad Sci USA, 71, pp. 1207-1210
Kazlauskas, A., Receptor tyrosine kinases and their targets (1994) Curr Opin Genet Dev, 4, pp. 5-14
Fredriksson, L., Li, H., Eriksson, U., The PDGF family: Four gene products form five dimeric isoforms (2004) Cytokine Growth Factor Rev, 15, pp. 197-204
Heldin, C.H., Westermark, B., Mechanism of action and in vivo role of platelet-derived growth factor (1999) Physiol Rev, 79, pp. 1283-1316
Fantl, W.J., Johnson, D.E., Williams, L.T., Signalling by receptor tyrosine kinases (1993) Annu Rev Biochem, 62, pp. 453-481
Matsui, T., Heidaran, M., Miki, T., Popescu, N., La Rochelle, W., Kraus, M., Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes (1989) Science, 243, pp. 800-804
Kelly, J.D., Haldeman, B.A., Grant, F.J., Murray, M.J., Seifert, R.A., Bowen-Pope, D.F., Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation (1991) J Biol Chem, 266, pp. 8987-8992
Andrae, J., Gallini, R., Betsholtz, C., Role of platelet-derived growth factors in physiology and medicine (2008) Genes Dev, 22, pp. 1276-1312
Heldin, C.H., Eriksson, U., Ostman, A., New members of the platelet-derived growth factor family of mitogens (2002) Arch Biochem Biophys, 398, pp. 284-290
Alvarez, R.H., Kantarjian, H.M., Cortes, J.E., Biology of platelet-derived growth factor and its involvement in disease (2006) Mayo Clin Proc, 81, pp. 1241-1257
Sundberg, C., Branting, M., Gerdin, B., Rubin, K., Tumor cell and connective tissue cell interactions in human colorectal adenocarcinoma. Transfer of platelet-derived growth factor-AB/BB to stromal cells (1997) Am J Pathol, 151, pp. 479-492
Yi, E.S., Lee, H., Yin, S., Piguet, P., Sarosi, I., Kaufmann, S., Platelet-derived growth factor causes pulmonary cell proliferation and collagen deposition in vivo (1996) Am J Pathol, 149, pp. 539-548
Rutherford, C., Martin, W., Carrier, M., Anggard, E.E., Ferns, G.A., Endogenously elicited antibodies to platelet derived growth factor- BB and platelet cytosolic protein inhibit aortic lesion development in the cholesterol-fed rabbit (1997) Int J Exp Pathol, 78, pp. 21-32
Abboud, H.E., Role of platelet-derived growth factor in renal injury (1995) Annu Rev Physiol, 57, pp. 297-309
Gesualdo, L., Di Paolo, S., Milani, S., Pinzani, M., Grappone, C., Ranieri, E., Expression of platelet-derived growth factor receptors in normal and diseased human kidney. An immunohistochemistry and in situ hybridization study (1994) J Clin Invest, 94, pp. 50-58
Gesualdo, L., Pinzani, M., Floriano, J.J., Hassan, M.O., Nagy, N.U., Schena, F.P., Platelet-derived growth factor expression in mesangial proliferative glomerulonephritis (1991) Lab Invest, 65, pp. 160-167
Yamamoto, M., Toya, Y., Jensen, R.A., Ishikawa, Y., Caveolin is an inhibitor of platelet-derived growth factor receptor signaling (1999) Exp Cell Res, 247, pp. 380-388
Engstrom, U., Engstrom, A., Ernlund, A., Westermark, B., Heldin, C.H., Identification of a peptide antagonist for platelet-derived growth factor (1992) J Biol Chem, 267, pp. 16581-16587
Brennand, D.M., Dennehy, U., Ellis, V., Scully, M.F., Tripathi, P., Kakkar, V.V., Identification of a cyclic peptide inhibitor of platelet-derived growth factor-BB receptor-binding and mitogen-induced DNA synthesis in human fibroblasts (1997) FEBS Lett, 413, pp. 70-74
Brennand, D.M., Scully, M.F., Kakkar, V.V., Patel, G., A cyclic peptide analogue of loop III of PDGF-BB causes apoptosis in human fibroblasts (1997) FEBS Lett, 419, pp. 166-170
Chiara, F., Bishayee, S., Heldin, C.H., Demoulin, J.B., Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail (2004) J Biol Chem, 279, pp. 19732-19738
Nagy, J.A., Dvorak, A.M., Dvorak, H.F., VEGF-A and the Induction of Pathological Angiogenesis. Annu Rev (2007) Pathol, 2, pp. 251-275
Park, J.E., Keller, G.A., Ferrara, N., The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF (1993) Mol Biol Cell, 4, pp. 1317-1326
Roth, D., Piekarek, M., Paulsson, M., Christ, H., Bloch, W., Krieg, T., Plasmin modulates vascular endothelial growth factor-Amediated angiogenesis during wound repair (2006) Am J Pathol, 168, pp. 670-684
Woolard, J., Wang, W.Y., Bevan, H.S., Qiu, Y., Morbidelli, L., Pritchard-Jones, R.O., VEGF165b, an inhibitory vascular endothelial growth factor splice variant: Mechanism of action, in vivo effect on angiogenesis and endogenous protein expression (2004) Cancer Res, 64, pp. 7822-7835
Maglione, D., Guerriero, V., Viglietto, G., Delli-Bovi, P., Persico, M.G., Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor (1991) Proc Natl Acad Sci USA, 88, pp. 9267-9271
Luttun, A., Tjwa, M., Carmeliet, P., Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): Novel therapeutic targets for angiogenic disorders (2002) Ann N Y Acad Sci, 979, pp. 80-93
Fischer, C., Jonckx, B., Mazzone, M., Zacchigna, S., Loges, S., Pattarini, L., Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels (2007) Cell, 131, pp. 463-475
Roy, H., Bhardwaj, S., Yla-Herttuala, S., Biology of vascular endothelial growth factors (2006) FEBS Lett, 580, pp. 2879-2887
Iyer, S., Acharya, K.R., Role of placenta growth factor in cardiovascular health (2002) Trends Cardiovasc Med, 12, pp. 128-134
Carmeliet, P., Moons, L., Luttun, A., Vincenti, V., Compernolle, V., De Mol, M., Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions (2001) Nat Med, 7, pp. 575-583
Hauser, S., Weich, H.A., A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta (1993) Growth Factors, 9, pp. 259-268
Ferrara, N., Gerber, H.P., LeCouter, J., The biology of VEGF and its receptors (2003) Nat Med, 9, pp. 669-676
Ferrara N. VEGF: An update on biological and therapeutic aspects. Curr Opin Biotechnol 2000
11: 617-24Ferrara, N., Davis-Smyth, T., The biology of vascular endothelial growth factor (1997) Endocr Rev, 18, pp. 4-25
Cross, M.J., Dixelius, J., Matsumoto, T., Claesson-Welsh, L., VEGF-receptor signal transduction (2003) Trends Biochem Sci, 28, pp. 488-494
Veikkola, T., Karkkainen, M., Claesson-Welsh, L., Alitalo, K., Regulation of angiogenesis via vascular endothelial growth factor receptors (2000) Cancer Res, 60, pp. 203-212
Hicklin, D.J., Ellis, L.M., Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis (2005) J Clin Oncol, 23, pp. 1011-1027
Hiratsuka, S., Minowa, O., Kuno, J., Noda, T., Shibuya, M., Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice (1998) Proc Natl Acad Sci USA, 95, pp. 9349-9354
Hattori, K., Heissig, B., Wu, Y., Dias, S., Tejada, R., Ferris, B., Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment (2002) Nat Med, 8, pp. 841-849
Autiero, M., Waltenberger, J., Communi, D., Kranz, A., Moons, L., Lambrechts, D., Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 (2003) Nat Med, 9, pp. 936-943
Kendall, R.L., Thomas, K.A., Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor (1993) Proc Natl Acad Sci USA, 90, pp. 10705-10709
Maynard, S.E., Min, J.Y., Merchan, J., Lim, K.H., Li, J., Mondal, S., Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia (2003) J Clin Invest, 111, pp. 649-658
Oliver, G., Alitalo, K., The lymphatic vasculature: Recent progress and paradigms (2005) Annu Rev Cell Dev Biol, 21, pp. 457-483
Alitalo, K., Tammela, T., Petrova, T.V., Lymphangiogenesis in development and human disease (2005) Nature, 438, pp. 946-953
Achen, M.G., Williams, R.A., Minekus, M.P., Thornton, G.E., Stenvers, K., Rogers, P.A., Localization of vascular endothelial growth factor D in malignant melanoma suggests a role in tumour angiogenesis (2001) J Pathol, 193, pp. 147-154
Valtola, R., Salven, P., Heikkila, P., Taipale, J., Joensuu, H., Rehn, M., VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer (1999) Am J Pathol, 154, pp. 1381-1390
Pellet-Many, C., Frankel, P., Jia, H., Zachary, I., Neuropilins: Structure, function and role in disease (2008) Biochem J, 411, pp. 211-226
Geretti, E., Shimizu, A., Klagsbrun, M., Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis (2008) Angiogenesis, 11, pp. 31-39
Muller, Y.A., Christinger, H.W., Keyt, B.A., de Vos, A.M., The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: Multiple copy flexibility and receptor binding (1997) Structure, 5, pp. 1325-1338
Muller, Y.A., Li, B., Christinger, H.W., Wells, J.A., Cunningham, B.C., de Vos, A.M., Vascular endothelial growth factor: Crystal structure and functional mapping of the kinase domain receptor binding site (1997) Proc Natl Acad Sci USA, 94, pp. 7192-7197
Pan, B., Li, B., Russell, S.J., Tom, J.Y., Cochran, A.G., Fairbrother, W.J., Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor (2002) J Mol Biol, 316, pp. 769-787
Wiesmann, C., Christinger, H.W., Cochran, A.G., Cunningham, B.C., Fairbrother, W.J., Keenan, C.J., Crystal structure of the complex between VEGF and a receptor-blocking peptide (1998) Biochemistry, 37, pp. 17765-17772
Muller, Y.A., Chen, Y., Christinger, H.W., Li, B., Cunningham, B.C., Lowman, H.B., VEGF and the Fab fragment of a humanized neutralizing antibody: Crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface (1998) Structure, 6, pp. 1153-1167
Starovasnik, M.A., Christinger, H.W., Wiesmann, C., Champe, M.A., de Vos, A.M., Skelton, N.J., Solution structure of the VEGF-binding domain of Flt-1: Comparison of its free and bound states (1999) J Mol Biol, 293, pp. 531-544
Wiesmann, C., Fuh, G., Christinger, H.W., Eigenbrot, C., Wells, J.A., de Vos, A.M., Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor (1997) Cell, 91, pp. 695-704
Christinger, H.W., Fuh, G., de Vos, A.M., Wiesmann, C., The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1 (2004) J Biol Chem, 279, pp. 10382-10388
McTigue, M.A., Wickersham, J.A., Pinko, C., Showalter, R.E., Parast, C.V., Tempczyk-Russell, A., Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: A key enzyme in angiogenesis (1999) Structure, 7, pp. 319-330
Ruch, C., Skiniotis, G., Steinmetz, M.O., Walz, T., Ballmer-Hofer, K., Structure of a VEGF-VEGF receptor complex determined by electron microscopy (2007) Nat Struct Mol Biol, 14, pp. 249-250
Keyt, B.A., Nguyen, H.V., Berleau, L.T., Duarte, C.M., Park, J., Chen, H., Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis (1996) J Biol Chem, 271, pp. 5638-5646
Lee, C.C., Kreusch, A., McMullan, D., Ng, K., Spraggon, G., Crystal structure of the human neuropilin-1 b1 domain (2003) Structure, 11, pp. 99-108
Appleton, B.A., Wu, P., Maloney, J., Yin, J., Liang, W.C., Stawicki, S., Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding (2007) Embo J, 26, pp. 4902-4912
Vander Kooi, C.W., Jusino, M.A., Perman, B., Neau, D.B., Bellamy, H.D., Leahy, D.J., Structural basis for ligand and heparin binding to neuropilin B domains (2007) Proc Natl Acad Sci USA, 104, pp. 6152-6157
Zachary, I., Vascular endothelial growth factor and anti-angiogenic peptides as therapeutic and investigational molecules (2003) IDrugs, 6, pp. 224-231
Ferrara, N., Hillan, K.J., Gerber, H.P., Novotny, W., Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer (2004) Nat Rev Drug Discov, 3, pp. 391-400
Underiner, T.L., Ruggeri, B., Gingrich, D.E., Development of vascular endothelial growth factor receptor (VEGFR) kinase inhibitors as anti-angiogenic agents in cancer therapy (2004) Curr Med Chem, 11, pp. 731-745
Sun, J., Blaskovich, M.A., Jain, R.K., Delarue, F., Paris, D., Brem, S., Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor (2004) Cancer Res, 64, pp. 3586-3592
Holash, J., Davis, S., Papadopoulos, N., Croll, S.D., Ho, L., Russell, M., VEGF-Trap: A VEGF blocker with potent antitumor effects (2002) Proc Natl Acad Sci USA, 99, pp. 11393-11398
Niethammer, A.G., Xiang, R., Becker, J.C., Wodrich, H., Pertl, U., Karsten, G., A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth (2002) Nat Med, 8, pp. 1369-1375
Takei, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S., Muramatsu, T., A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics (2004) Cancer Res, 64, pp. 3365-3370
Quesada, A.R., Munoz-Chapuli, R., Medina, M.A., Anti-angiogenic drugs: From bench to clinical trials (2006) Med Res Rev, 26, pp. 483-530
Jia, H., Jezequel, S., Lohr, M., Shaikh, S., Davis, D., Soker, S., Peptides encoded by exon 6 of VEGF inhibit endothelial cell biological responses and angiogenesis induced by VEGF (2001) Biochem Biophys Res Commun, 283, pp. 164-173
Bainbridge, J.W., Jia, H., Bagherzadeh, A., Selwood, D., Ali, R.R., Zachary, I., A peptide encoded by exon 6 of VEGF (EG3306) inhibits VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivo (2003) Biochem Biophys Res Commun, 302, pp. 793-799
Cheng, L., Jia, H., Lohr, M., Bagherzadeh, A., Holmes, D.I., Selwood, D., Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production (2004) J Biol Chem, 279, pp. 30654-30661
Giordano, R.J., Cardo-Vila, M., Lahdenranta, J., Pasqualini, R., Arap, W., Biopanning and rapid analysis of selective interactive ligands (2001) Nat Med, 7, pp. 1249-1253
Giordano, R.J., Anobom, C.D., Cardo-Vila, M., Kalil, J., Valente, A.P., Pasqualini, R., Structural basis for the interaction of a vascular endothelial growth factor mimic peptide motif and its corresponding receptors (2005) Chem Biol, 12, pp. 1075-1083
Binetruy-Tournaire, R., Demangel, C., Malavaud, B., Vassy, R., Rouyre, S., Kraemer, M., Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis (2000) Embo J, 19, pp. 1525-1533
Perret, G.Y., Starzec, A., Hauet, N., Vergote, J., Le Pecheur, M., Vassy, R., In vitro evaluation and biodistribution of a 99mTc-labeled anti-VEGF peptide targeting neuropilin-1 (2004) Nucl Med Biol, 31, pp. 575-581
Starzec, A., Vassy, R., Martin, A., Lecouvey, M., Di Benedetto, M., Crepin, M., Antiangiogenic and antitumor activities of peptide inhibiting the vascular endothelial growth factor binding to neuropilin-1 (2006) Life Sci, 79, pp. 2370-2381
Starzec, A., Ladam, P., Vassy, R., Badache, S., Bouchemal, N., Navaza, A., Structure-function analysis of the antiangiogenic ATWLPPR peptide inhibiting VEGF(165) binding to neuropilin-1 and molecular dynamics simulations of the ATWLPPR/neuropilin-1 complex (2007) Peptides, 28, pp. 2397-2402
Bae, D.G., Kim, T.D., Li, G., Yoon, W.H., Chae, C.B., Anti-flt1 peptide, a vascular endothelial growth factor receptor 1-specific hexapeptide, inhibits tumor growth and metastasis (2005) Clin Cancer Res, 11, pp. 2651-2661
von Wronski, M.A., Raju, N., Pillai, R., Bogdan, N.J., Marinelli, E.R., Nanjappan, P., Tuftsin binds neuropilin-1 through a sequence similar to that encoded by exon 8 of vascular endothelial growth factor (2006) J Biol Chem, 281, pp. 5702-5710
Qin, X., Wan, Y., Li, M., Xue, X., Wu, S., Zhang, C., Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy (2007) J Biochem, 142, pp. 79-85
Shrivastava, A., von Wronski, M.A., Sato, A.K., Dransfield, D.T., Sexton, D., Bogdan, N., A distinct strategy to generate high-affinity peptide binders to receptor tyrosine kinases (2005) Protein Eng Des Sel, 18, pp. 417-424
Goncalves, V., Gautier, B., Coric, P., Bouaziz, S., Lenoir, C., Garbay, C., Rational design, structure, and biological evaluation of cyclic peptides mimicking the vascular endothelial growth factor (2007) J Med Chem, 50, pp. 5135-5146
Taylor, A.P., Goldenberg, D.M., Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts (2007) Mol Cancer Ther, 6, pp. 524-531
Udugamasooriya, D.G., Dineen, S.P., Brekken, R.A., Kodadek, T., A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity (2008) J Am Chem Soc, 130, pp. 5744-5752
Albini, A., Soldi, R., Giunciuglio, D., Giraudo, E., Benelli, R., Primo, L., The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells (1996) Nat Med, 2, pp. 1371-1375
D'Andrea, L.D., Iaccarino, G., Fattorusso, R., Sorriento, D., Carannante, C., Capasso, D., Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (2005) Proc Natl Acad Sci USA, 102, pp. 14215-14220
Dudar, G.K., D'Andrea, L.D., Di Stasi, R., Pedone, C., Wallace, J.L., A Vascular Endothelial Growth Factor Mimetic Accelerates Gastric Ulcer Healing in an iNOS-Dependent Manner (2008) Am J Physiol, , Gastrointest Liver Physiol
Waslif, J., (2004) Angiogenesis Inhibitors and Stimulators:tHe Emergence of a New Market
Jacobs, J., Combating cardiovascular disease with angiogenic therapy (2007) Drug Discov Today, 12, pp. 1040-1045
Kerbel, R., Folkman, J., Clinical translation of angiogenesis inhibitors (2002) Nat Rev Cancer, 2, pp. 727-739
Featherstone, J., Griffiths, S., From the analyst's couch. Drugs that target angiogenesis (2002) Nat Rev Drug Discov, 1, pp. 413-414
Cristofanilli, M., Charnsangavej, C., Hortobagyi, G.N., Angiogenesis modulation in cancer research: Novel clinical approaches (2002) Nat Rev Drug Discov, 1, pp. 415-426
Ferrara, N., Alitalo, K., Clinical applications of angiogenic growth factors and their inhibitors (1999) Nat Med, 5, pp. 1359-1364
Choe, Y.S., Lee, K.H., Targeted in vivo imaging of angiogenesis: Present status and perspectives (2007) Curr Pharm Des, 13, pp. 17-31
Ferrara, N., Mass, R.D., Campa, C., Kim, R., Targeting VEGF-A to treat cancer and age-related macular degeneration (2007) Annu Rev Med, 58, pp. 491-504
Million, R.P., Therapeutic area crossroads:aNti-angiogenesis (2008) Nature Rev. Drug Discov, 7, pp. 115-116
Simons, M., Ware, J.A., Therapeutic angiogenesis in cardiovascular disease (2003) Nat Rev Drug Discov, 2, pp. 863-871
Weis, S.M., Cheresh, D.A., Pathophysiological consequences of VEGF-induced vascular permeability (2005) Nature, 437, pp. 497-504
Lee, C.G., Link, H., Baluk, P., Homer, R.J., Chapoval, S., Bhandari, V., Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung (2004) Nat Med, 10, pp. 1095-1103
Molin, D., Post, M.J., Therapeutic angiogenesis in the heart: Protect and serve (2007) Curr Opin Pharmacol, 7, pp. 158-163
Emanueli, C., Madeddu, P., Changing the logic of therapeutic angiogenesis for ischemic disease (2005) Trends Mol Med, 11, pp. 207-216
Hetian, L., Ping, A., Shumei, S., Xiaoying, L., Luowen, H., Jian, W., A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor (2002) J Biol Chem, 277, pp. 43137-43142
Zilberberg, L., Shinkaruk, S., Lequin, O., Rousseau, B., Hagedorn, M., Costa, F., Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor (2003) J Biol Chem, 278, pp. 35564-35573
El-Mousawi, M., Tchistiakova, L., Yurchenko, L., Pietrzynski, G., Moreno, M., Stanimirovic, D., A vascular endothelial growth factor high affinity receptor 1-specific peptide with antiangiogenic activity identified using a phage display peptide library (2003) J Biol Chem, 278, pp. 46681-46691
An, P., Lei, H., Zhang, J., Song, S., He, L., Jin, G., Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library (2004) Int J Cancer, 111, pp. 165-173
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T, Review,
Impact factor: 4.414, 5-year impact factor: 3.988
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-69249113838&partnerID=40&md5=10fae5d9f0525db438ec669e564d7f35
Keywords: Angiogenesis, Fgf, Growth Factor, Pdgf, Peptide, Vegf, Angiogenesis Inhibitor, Angiogenic Factor, Becaplermin, Bevacizumab, Fibroblast Growth Factor, Fibroblast Growth Factor 1 Antagonist, Fibroblast Growth Factor 2 Antagonist, Fibroblast Growth Factor 5 Antagonist, Fibroblast Growth Factor Receptor, Matrix Metalloproteinase, Platelet Derived Growth Factor, Platelet Derived Growth Factor Bb, Platelet Derived Growth Factor Receptor, Protein Inhibitor, Proteoheparan Sulfate, Recombinant Platelet Derived Growth Factor Bb, Unclassified Drug, Vasculotropin, Vasculotropin Receptor 1, Cell Interaction, Cell Migration, Cell Proliferation, Gene Expression Regulation, Hair Loss, Nonhuman, Priority Journal, Protein Expression, Protein Function, Protein Phosphorylation, Protein Protein Interaction, Protein Structure, Receptor Binding, Review, Structure Analysis, Animals, Intercellular Signaling Peptides And Proteins, Neovascularization, Pathologic, Platelet-Derived Growth Factor, Signal Transduction, Vascular Endothelial Growth Factor A,
Affiliations:
*** IBB - CNR ***
Dipartimento delle Scienze Biologiche, Facolta di Scienze Biotecnologiche, Universita di Napoli Federico II, via Mezzocannone 16, 80134 Napoli, Italy. ldandrea@unina.it
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Napoli, Italy
References:
Hanahan, D., Folkman, J., Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis (1996) Cell, 86, pp. 353-36
Bergers, G., Benjamin, L.E., Tumorigenesis and the angiogenic switch (2003) Nat Rev Cancer, 3, pp. 401-410
Adams, R.H., Alitalo, K., Molecular regulation of angiogenesis and lymphangiogenesis (2007) Nat Rev Mol Cell Biol, 8, pp. 464-478
Carmeliet, P., Jain, R.K., Angiogenesis in cancer and other diseases (2000) Nature, 407, pp. 249-257
Folkman, J., Angiogenesis in cancer, vascular, rheumatoid and other disease (1995) Nat Med, 1, pp. 27-31
Carmeliet, P., Angiogenesis in life, disease and medicine (2005) Nature, 438, pp. 932-936
Ferrara, N., Kerbel, R.S., Angiogenesis as a therapeutic target (2005) Nature, 438, pp. 967-974
Bouis, D., Kusumanto, Y., Meijer, C., Mulder, N.H., Hospers, G.A., A review on pro- and anti-angiogenic factors as targets of clinical intervention (2006) Pharmacol Res, 53, pp. 89-103
Yancopoulos, G.D., Davis, S., Gale, N.W., Rudge, J.S., Wiegand, S.J., Holash, J., Vascular-specific growth factors and blood vessel formation (2000) Nature, 407, pp. 242-248
Rajkumar, T., Growth factoprs and growth factor receptors in cancer (2001) Current Science, 81, pp. 535-241
Heppeler, A., Froidevaux, S., Eberle, A.N., Maecke, H.R., Receptor targeting for tumor localisation and therapy with radiopeptides (2000) Curr Med Chem, 7, pp. 971-994
Okarvi, S.M., Peptide-based radiopharmaceuticals: Future tools for diagnostic imaging of cancers and other diseases (2004) Med Res Rev, 24, pp. 357-397
Ruegg, C., Hasmim, M., Lejeune, F.J., Alghisi, G.C., Antiangiogenic peptides and proteins: From experimental tools to clinical drugs (2006) Biochim Biophys Acta, 1765, pp. 155-177
D'Andrea, L.D., Del Gatto, A., Pedone, C., Benedetti, E., Peptide-based molecules in angiogenesis (2006) Chem Biol Drug Des, 67, pp. 115-126
Dings, R.P., Nesmelova, I., Griffioen, A.W., Mayo, K.H., Discovery and development of anti-angiogenic peptides: A structural link (2003) Angiogenesis, 6, pp. 83-91
Sulochana, K.N., Ge, R., Developing antiangiogenic peptide drugs for angiogenesis-related diseases (2007) Curr Pharm Des, 13, pp. 2074-2086
Bouma-ter Steege, J.C., Mayo, K.H., Griffioen, A.W., Angiostatic proteins and peptides (2001) Crit Rev Eukaryot Gene Expr, 11, pp. 319-334
Folkman, J., Merler, E., Abernathy, C., Williams, G., Isolation of a tumor factor responsible for angiogenesis (1971) J Exp Med, 133, pp. 275-288
Abraham, J.A., Whang, J.L., Tumolo, A., Mergia, A., Fiddes, J.C., Human basic fibroblast growth factor: Nucleotide sequence, genomic organization, and expression in mammalian cells (1986) Cold Spring Harb Symp Quant Biol, 51 (PART 1), pp. 657-668
Abraham, J.A., Mergia, A., Whang, J.L., Tumolo, A., Friedman, J., Hjerrild, K.A., Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor (1986) Science, 233, pp. 545-548
Powers, C.J., McLeskey, S.W., Wellstein, A., Fibroblast growth factors, their receptors and signaling (2000) Endocr Relat Cancer, 7, pp. 165-197
Ago, H., Kitagawa, Y., Fujishima, A., Matsuura, Y., Katsube, Y., Crystal structure of basic fibroblast growth factor at 1.6 A resolution (1991) J Biochem, 110, pp. 360-363
Eriksson, A.E., Cousens, L.S., Weaver, L.H., Matthews, B.W., Three-dimensional structure of human basic fibroblast growth factor (1991) Proc Natl Acad Sci USA, 88, pp. 3441-3445
Zhu, X., Komiya, H., Chirino, A., Faham, S., Fox, G.M., Arakawa, T., Three-dimensional structures of acidic and basic fibroblast growth factors (1991) Science, 251, pp. 90-93
Zhang, J.D., Cousens, L.S., Barr, P.J., Sprang, S.R., Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta (1991) Proc Natl Acad Sci USA, 88, pp. 3446-3450
Reuss, B., von Bohlen, Halbach, O., Fibroblast growth factors and their receptors in the central nervous system (2003) Cell Tissue Res, 313, pp. 139-157
Ornitz DM, Itoh N. Fibroblast growth factors. Genome Biol 2001
2: reviews3005.1-3005.12Klagsbrun, M., Baird, A., A dual receptor system is required for basic fibroblast growth factor activity (1991) Cell, 67, pp. 229-231
Saksela, O., Moscatelli, D., Sommer, A., Rifkin, D.B., Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation (1988) J Cell Biol, 107, pp. 743-751
Turnbull, J.E., Gallagher, J.T., Heparan sulphate: Functional role as a modulator of fibroblast growth factor activity (1993) Biochem Soc Trans, 21, pp. 477-482
David, G., Integral membrane heparan sulfate proteoglycans (1993) Faseb J, 7, pp. 1023-1030
Ornitz, D.M., Leder, P., Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3 (1992) J Biol Chem, 267, pp. 16305-16311
Mansukhani, A., Dell'Era, P., Moscatelli, D., Kornbluth, S., Hanafusa, H., Basilico, C., Characterization of the murine BEK fibroblast growth factor (FGF) receptor: Activation by three members of the FGF family and requirement for heparin (1992) Proc Natl Acad Sci USA, 89, pp. 3305-3309
Yayon, A., Klagsbrun, M., Esko, J.D., Leder, P., Ornitz, D.M., Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor (1991) Cell, 64, pp. 841-848
Rapraeger, A.C., Krufka, A., Olwin, B.B., Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation (1991) Science, 252, pp. 1705-1708
Chaffer, C.L., Dopheide, B., Savagner, P., Thompson, E.W., Williams, E.D., Aberrant fibroblast growth factor receptor signaling in bladder and other cancers (2007) Differentiation, 75, pp. 831-842
Lee, P.L., Johnson, D.E., Cousens, L.S., Fried, V.A., Williams, L.T., Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor (1989) Science, 245, pp. 57-60
Reid, H.H., Wilks, A.F., Bernard, O., Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain (1990) Proc Natl Acad Sci USA, 87, pp. 1596-1600
Safran, A., Avivi, A., Orr-Urtereger, A., Neufeld, G., Lonai, P., Givol, D., The murine flg gene encodes a receptor for fibroblast growth factor (1990) Oncogene, 5, pp. 635-643
Dionne, C.A., Crumley, G., Bellot, F., Kaplow, J.M., Searfoss, G., Ruta, M., Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors (1990) EMBO J, 9, pp. 2685-2692
Keegan, K., Johnson, D.E., Williams, L.T., Hayman, M.J., Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3 (1991) Proc Natl Acad Sci USA, 88, pp. 1095-1099
Partanen, J., Makela, T.P., Eerola, E., Korhonen, J., Hirvonen, H., Claesson-Welsh, L., FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern (1991) EMBO J, 10, pp. 1347-1354
Stark, K.L., McMahon, J.A., McMahon, A.P., FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse (1991) Development, 113, pp. 641-651
Zhang, X., Ibrahimi, O.A., Olsen, S.K., Umemori, H., Mohammadi, M., Ornitz, D.M., Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family (2006) J Biol Chem, 281, pp. 15694-15700
Stauber, D.J., DiGabriele, A.D., Hendrickson, W.A., Structural interactions of fibroblast growth factor receptor with its ligands (2000) Proc Natl Acad Sci USA, 97, pp. 49-54
Venkataraman, G., Shriver, Z., Davis, J.C., Sasisekharan, R., Fibroblast growth factors 1 and 2 are distinct in oligomerization in the presence of heparin-like glycosaminoglycans (1999) Proc Natl Acad Sci USA, 96, pp. 1892-1897
Zhan, X., Plourde, C., Hu, X., Friesel, R., Maciag, T., Association of fibroblast growth factor receptor-1 with c-Src correlates with association between c-Src and cortactin (1994) J Biol Chem, 269, pp. 20221-20224
Cross, M.J., Claesson-Welsh, L., FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition (2001) Trends Pharmacol Sci, 22, pp. 201-207
Cross, M.J., Hodgkin, M.N., Roberts, S., Landgren, E., Wakelam, M.J., Claesson-Welsh, L., Tyrosine 766 in the fibroblast growth factor receptor 1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells (2000) J Cell Sci, 113 (PART 4), pp. 643-651
Raffioni, S., Thomas, D., Foehr, E.D., Thompson, L.M., Bradshaw, R.A., Comparison of the intracellular signaling responses by three chimeric fibroblast growth factor receptors in PC12 cells (1999) Proc Natl Acad Sci USA, 96, pp. 7178-7183
Presta, M., Dell'Era, P., Mitola, S., Moroni, E., Ronca, R., Rusnati, M., Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis (2005) Cytokine Growth Factor Rev, 16, pp. 159-178
Rusnati, M., Presta, M., Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies (2007) Curr Pharm Des, 13, pp. 2025-2044
Mignatti, P., Rifkin, D.B., Nonenzymatic interactions between proteinases and the cell surface: Novel roles in normal and malignant cell physiology (2000) Adv Cancer Res, 78, pp. 103-157
Stokes, C.L., Rupnick, M.A., Williams, S.K., Lauffenburger, D.A., Chemotaxis of human microvessel endothelial cells in response to acidic fibroblast growth factor (1990) Lab Invest, 63, pp. 657-668
Terranova, V.P., DiFlorio, R., Lyall, R.M., Hic, S., Friesel, R., Maciag, T., Human endothelial cells are chemotactic to endothelial cell growth factor and heparin (1985) J Cell Biol, 101, pp. 2330-2334
Mattila, M.M., Ruohola, J.K., Valve, E.M., Tasanen, M.J., Seppanen, J.A., Harkonen, P.L., FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells (2001) Oncogene, 20, pp. 2791-2804
Gillis, P., Savla, U., Volpert, O.V., Jimenez, B., Waters, C.M., Panos, R.J., Keratinocyte growth factor induces angiogenesis and protects endothelial barrier function (1999) J Cell Sci, 112 (PART 12), pp. 2049-2057
Klein, S., Giancotti, F.G., Presta, M., Albelda, S.M., Buck, C.A., Rifkin, D.B., Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells (1993) Mol Biol Cell, 4, pp. 973-982
Collo, G., Pepper, M.S., Endothelial cell integrin alpha5beta1 expression is modulated by cytokines and during migration in vitro (1999) J Cell Sci, 112 (PART 4), pp. 569-578
Sepp, N.T., Li, L.J., Lee, K.H., Brown, E.J., Caughman, S.W., Lawley, T.J., Basic fibroblast growth factor increases expression of the alpha v beta 3 integrin complex on human microvascular endothelial cells (1994) J Invest Dermatol, 103, pp. 295-299
Underwood, P.A., Bean, P.A., Gamble, J.R., Rate of endothelial expansion is controlled by cell:cEll adhesion (2002) Int J Biochem Cell Biol, 34, pp. 55-69
Zhou, L., Dosanjh, A., Chen, H., Karasek, M., Divergent effects of extracellular oxygen on the growth, morphology, and function of human skin microvascular endothelial cells (2000) J Cell Physiol, 182, pp. 134-140
Gualandris, A., Rusnati, M., Belleri, M., Nelli, E.E., Bastaki, M., Molinari-Tosatti, M.P., Basic fibroblast growth factor overexpression in endothelial cells: An autocrine mechanism for angiogenesis and angioproliferative diseases (1996) Cell Growth Differ, 7, pp. 147-160
Armstrong, E., Vainikka, S., Partanen, J., Korhonen, J., Alitalo, R., Expression of fibroblast growth factor receptors in human leukemia cells (1992) Cancer Res, 52, pp. 2004-2007
Allouche, M., Bayard, F., Clamens, S., Fillola, G., Sie, P., Amalric, F., Expression of basic fibroblast growth factor (bFGF) and FGF-receptors in human leukemic cells (1995) Leukemia, 9, pp. 77-86
Katoh, O., Hattori, Y., Sato, T., Kimura, A., Kuramoto, A., Sugimura, T., Expression of the heparin-binding growth factor receptor genes in human megakaryocytic leukemia cells (1992) Biochem Biophys Res Commun, 183, pp. 83-92
Liuzzo, J.P., Moscatelli, D., Human leukemia cell lines bind basic fibroblast growth factor (FGF) on FGF receptors and heparan sulfates: Downmodulation of FGF receptors by phorbol ester (1996) Blood, 87, pp. 245-255
Basilico, C., Moscatelli, D., The FGF family of growth factors and oncogenes (1992) Adv Cancer Res, 59, pp. 115-165
Hagedorn, M., Bikfalvi, A., Target molecules for anti-angiogenic therapy: From basic research to clinical trials (2000) Crit Rev Oncol Hematol, 34, pp. 89-110
Tille, J.C., Wood, J., Mandriota, S.J., Schnell, C., Ferrari, S., Mestan, J., Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth factor-induced angiogenesis in vivo and in vitro (2001) J Pharmacol Exp Ther, 299, pp. 1073-1085
Seghezzi, G., Patel, S., Ren, C.J., Gualandris, A., Pintucci, G., Robbins, E.S., Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: An autocrine mechanism contributing to angiogenesis (1998) J Cell Biol, 141, pp. 1659-1673
Lindahl, U., Lidholt, K., Spillmann, D., Kjellen, L., More to "heparin" than anticoagulation (1994) Thromb Res, 75, pp. 1-32
Iozzo, R.V., San Antonio, J.D., Heparan sulfate proteoglycans: Heavy hitters in the angiogenesis arena (2001) J Clin Invest, 108, pp. 349-355
Ribatti, D., Leali, D., Vacca, A., Giuliani, R., Gualandris, A., Roncali, L., In vivo angiogenic activity of urokinase: Role of endogenous fibroblast growth factor-2 (1999) J Cell Sci, 112 (PART 23), pp. 4213-4221
Presta, M., Maier, J.A., Rusnati, M., Ragnotti, G., Basic fibroblast growth factor is released from endothelial extracellular matrix in a biologically active form (1989) J Cell Physiol, 140, pp. 68-74
Simons, M., Horowitz, A., Syndecan-4-mediated signalling (2001) Cell Signal, 13, pp. 855-862
Rusnati, M., Urbinati, C., Presta, M., Internalization of basic fibroblast growth factor (bFGF) in cultured endothelial cells: Role of the low affinity heparin-like bFGF receptors (1993) J Cell Physiol, 154, pp. 152-161
Hsia, E., Richardson, T.P., Nugent, M.A., Nuclear localization of basic fibroblast growth factor is mediated by heparan sulfate proteoglycans through protein kinase C signaling (2003) J Cell Biochem, 88, pp. 1214-1225
Gajdusek, C.M., Carbon, S., Injury-induced release of basic fibroblast growth factor from bovine aortic endothelium (1989) J Cell Physiol, 139, pp. 570-579
Gloe, T., Sohn, H.Y., Meininger, G.A., Pohl, U., Shear stress-induced release of basic fibroblast growth factor from endothelial cells is mediated by matrix interaction via integrin alpha(v)beta3 (2002) J Biol Chem, 277, pp. 23453-23458
Hartnett, M.E., Garcia, C.M., D'Amore, P.A., Release of bFGF, an endothelial cell survival factor, by osmotic shock (1999) Invest Ophthalmol Vis Sci, 40, pp. 2945-2951
Pugh, C.W., Oxygen sensing in cancer (2003) Ann Med, 35, pp. 380-390
Kuwabara, K., Ogawa, S., Matsumoto, M., Koga, S., Clauss, M., Pinsky, D.J., Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells (1995) Proc Natl Acad Sci USA, 92, pp. 4606-4610
Li, J., Shworak, N.W., Simons, M., Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites (2002) J Cell Sci, 115, pp. 1951-1959
Ornitz, D.F., heparan sulfate and FGFRs: Complex interactions essential for development (2000) Bioessays, 22, pp. 108-112
Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M., Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity (2000) Cell, 101, pp. 413-424
Moy, F.J., Seddon, A.P., Bohlen, P., Powers, R., High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy (1996) Biochemistry, 35, pp. 13552-13561
Li, L.Y., Safran, M., Aviezer, D., Bohlen, P., Seddon, A.P., Yayon, A., Diminished heparin binding of a basic fibroblast growth factor mutant is associated with reduced receptor binding, mitogenesis, plasminogen activator induction, and in vitro angiogenesis (1994) Biochemistry, 33, pp. 10999-11007
Blaber, M., DiSalvo, J., Thomas, K.A., X-ray crystal structure of human acidic fibroblast growth factor (1996) Biochemistry, 35, pp. 2086-2094
Faham, S., Hileman, R.E., Fromm, J.R., Linhardt, R.J., Rees, D.C., Heparin structure and interactions with basic fibroblast growth factor (1996) Science, 271, pp. 1116-1120
DiGabriele, A.D., Lax, I., Chen, D.I., Svahn, C.M., Jaye, M., Schlessinger, J., Structure of a heparin-linked biologically active dimer of fibroblast growth factor (1998) Nature, 393, pp. 812-817
Plotnikov, A.N., Schlessinger, J., Hubbard, S.R., Mohammadi, M., Structural basis for FGF receptor dimerization and activation (1999) Cell, 98, pp. 641-650
Ornitz, D.M., Yayon, A., Flanagan, J.G., Svahn, C.M., Levi, E., Leder, P., Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells (1992) Mol Cell Biol, 12, pp. 240-247
Sudhalter, J., Folkman, J., Svahn, C.M., Bergendal, K., D'Amore, P.A., Importance of size, sulfation, and anticoagulant activity in the potentiation of acidic fibroblast growth factor by heparin (1989) J Biol Chem, 264, pp. 6892-6897
Schlessinger, J., Plotnikov, A.N., Ibrahimi, O.A., Eliseenkova, A.V., Yeh, B.K., Yayon, A., Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization (2000) Mol Cell, 6, pp. 743-750
Pellegrini, L., Burke, D.F., von Delft, F., Mulloy, B., Blundell, T.L., Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin (2000) Nature, 407, pp. 1029-1034
Kan, M., Wang, F., Xu, J., Crabb, J.W., Hou, J., McKeehan, W.L., An essential heparin-binding domain in the fibroblast growth factor receptor kinase (1993) Science, 259, pp. 1918-1921
Schubert, D., Ling, N., Baird, A., Multiple influences of a heparin-binding growth factor on neuronal development (1987) J Cell Biol, 104, pp. 635-643
Baird, A., Schubert, D., Ling, N., Guillemin, R., Receptor- and heparin-binding domains of basic fibroblast growth factor (1988) Proc Natl Acad Sci USA, 85, pp. 2324-2328
Ray, J., Baird, A., Gage, F.H., A 10-amino acid sequence of fibroblast growth factor 2 is sufficient for its mitogenic activity on neural progenitor cells (1997) Proc Natl Acad Sci USA, 94, pp. 7047-7052
Williams, E.J., Williams, G., Howell, F.V., Skaper, S.D., Walsh, F.S., Doherty, P., Identification of an N-cadherin motif that can interact with the fibroblast growth factor receptor and is required for axonal growth (2001) J Biol Chem, 276, pp. 43879-43886
Ito, C., Saitoh, Y., Fujita, Y., Yamazaki, Y., Imamura, T., Oka, S., Decapeptide with fibroblast growth factor (FGF)-5 partial sequence inhibits hair growth suppressing activity of FGF-5 (2003) J Cell Physiol, 197, pp. 272-283
Yayon, A., Aviezer, D., Safran, M., Gross, J.L., Heldman, Y., Cabilly, S., Isolation of peptides that inhibit binding of basic fibroblast growth factor to its receptor from a random phage-epitope library (1993) Proc Natl Acad Sci USA, 90, pp. 10643-10647
Terada, T., Mizobata, M., Kawakami, S., Yabe, Y., Yamashita, F., Hashida, M., Basic fibroblast growth factor-binding peptide as a novel targeting ligand of drug carrier to tumor cells (2006) J Drug Target, 14, pp. 536-545
Maruta, F., Parker, A.L., Fisher, K.D., Hallissey, M.T., Ismail, T., Rowlands, D.C., Identification of FGF receptor-binding peptides for cancer gene therapy (2002) Cancer Gene Ther, 9, pp. 543-552
Cosic, I., Drummond, A.E., Underwood, J.R., Hearn, M.T., In vitro inhibition of the actions of basic FGF by a novel 16 amino acid peptide (1994) Mol Cell Biochem, 130, pp. 1-9
McConnell, S.J., Thon, V.J., Spinella, D.G., Isolation of fibroblast growth factor receptor binding sequences using evolved phage display libraries (1999) Comb Chem High Throughput Screen, 2, pp. 155-163
Fan, H., Duan, Y., Zhou, H., Li, W., Li, F., Guo, L., Selection of peptide ligands binding to fibroblast growth factor receptor 1 (2002) IUBMB Life, 54, pp. 67-72
Oyama Jr., S., Miranda, M.T., Toma, I.N., Viviani, W., Gambarini, A.G., Mitogenic activity of peptides related to the sequence of human fibroblast growth factor-1 (1996) Biochem Mol Biol Int, 39, pp. 1237-1244
Kiyota, S., Franzoni, L., Nicastro, G., Benedetti, A., Oyama Jr., S., Viviani, W., Introduction of a chemical constraint in a short peptide derived from human acidic fibroblast growth factor elicits mitogenic structural determinants (2003) J Med Chem, 46, pp. 2325-2333
Tzeng, S.F., Deibler, G.E., DeVries, G.H., Myelin basic protein and myelin basic protein peptides induce the proliferation of Schwann cells via ganglioside GM1 and the FGF receptor (1999) Neurochem Res, 24, pp. 255-260
Li, S., Christensen, C., Kiselyov, V.V., Kohler, L.B., Bock, E., Berezin, V., Fibroblast growth factor-derived peptides: Functional agonists of the fibroblast growth factor receptor (2008) J Neurochem, 104, pp. 667-682
Anderson, A.A., Kendal, C.E., Garcia-Maya, M., Kenny, A.V., Morris-Triggs, S.A., Wu, T., A peptide from the first fibronectin domain of NCAM acts as an inverse agonist and stimulates FGF receptor activation, neurite outgrowth and survival (2005) J Neurochem, 95, pp. 570-583
Ballinger, M.D., Shyamala, V., Forrest, L.D., Deuter-Reinhard, M., Doyle, L.V., Wang, J.X., Semirational design of a potent, artificial agonist of fibroblast growth factor receptors (1999) Nat Biotechnol, 17, pp. 1199-1204
Kiselyov, V.V., Skladchikova, G., Hinsby, A.M., Jensen, P.H., Kulahin, N., Soroka, V., Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP (2003) Structure, 11, pp. 691-701
Neiiendam, J.L., Kohler, L.B., Christensen, C., Li, S., Pedersen, M.V., Ditlevsen, D.K., An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons (2004) J Neurochem, 91, pp. 920-935
Lin, X., Takahashi, K., Campion, S.L., Liu, Y., Gustavsen, G.G., Pena, L.A., Synthetic peptide F2A4-K-NS mimics fibroblast growth factor-2 in vitro and is angiogenic in vivo (2006) Int J Mol Med, 17, pp. 833-839
Lin, X., Pena, L.A., Zamora, P.O., Campion, S.L., Takahashi, K., Augmentation of demineralized bone matrix (DBM) mineralization by a synthetic growth factor mimetic (2006) J Orthop Res, 24, pp. 2051-2058
Ross, R., Glomset, J., Kariya, B., Harker, L., A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro (1974) Proc Natl Acad Sci USA, 71, pp. 1207-1210
Kazlauskas, A., Receptor tyrosine kinases and their targets (1994) Curr Opin Genet Dev, 4, pp. 5-14
Fredriksson, L., Li, H., Eriksson, U., The PDGF family: Four gene products form five dimeric isoforms (2004) Cytokine Growth Factor Rev, 15, pp. 197-204
Heldin, C.H., Westermark, B., Mechanism of action and in vivo role of platelet-derived growth factor (1999) Physiol Rev, 79, pp. 1283-1316
Fantl, W.J., Johnson, D.E., Williams, L.T., Signalling by receptor tyrosine kinases (1993) Annu Rev Biochem, 62, pp. 453-481
Matsui, T., Heidaran, M., Miki, T., Popescu, N., La Rochelle, W., Kraus, M., Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes (1989) Science, 243, pp. 800-804
Kelly, J.D., Haldeman, B.A., Grant, F.J., Murray, M.J., Seifert, R.A., Bowen-Pope, D.F., Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation (1991) J Biol Chem, 266, pp. 8987-8992
Andrae, J., Gallini, R., Betsholtz, C., Role of platelet-derived growth factors in physiology and medicine (2008) Genes Dev, 22, pp. 1276-1312
Heldin, C.H., Eriksson, U., Ostman, A., New members of the platelet-derived growth factor family of mitogens (2002) Arch Biochem Biophys, 398, pp. 284-290
Alvarez, R.H., Kantarjian, H.M., Cortes, J.E., Biology of platelet-derived growth factor and its involvement in disease (2006) Mayo Clin Proc, 81, pp. 1241-1257
Sundberg, C., Branting, M., Gerdin, B., Rubin, K., Tumor cell and connective tissue cell interactions in human colorectal adenocarcinoma. Transfer of platelet-derived growth factor-AB/BB to stromal cells (1997) Am J Pathol, 151, pp. 479-492
Yi, E.S., Lee, H., Yin, S., Piguet, P., Sarosi, I., Kaufmann, S., Platelet-derived growth factor causes pulmonary cell proliferation and collagen deposition in vivo (1996) Am J Pathol, 149, pp. 539-548
Rutherford, C., Martin, W., Carrier, M., Anggard, E.E., Ferns, G.A., Endogenously elicited antibodies to platelet derived growth factor- BB and platelet cytosolic protein inhibit aortic lesion development in the cholesterol-fed rabbit (1997) Int J Exp Pathol, 78, pp. 21-32
Abboud, H.E., Role of platelet-derived growth factor in renal injury (1995) Annu Rev Physiol, 57, pp. 297-309
Gesualdo, L., Di Paolo, S., Milani, S., Pinzani, M., Grappone, C., Ranieri, E., Expression of platelet-derived growth factor receptors in normal and diseased human kidney. An immunohistochemistry and in situ hybridization study (1994) J Clin Invest, 94, pp. 50-58
Gesualdo, L., Pinzani, M., Floriano, J.J., Hassan, M.O., Nagy, N.U., Schena, F.P., Platelet-derived growth factor expression in mesangial proliferative glomerulonephritis (1991) Lab Invest, 65, pp. 160-167
Yamamoto, M., Toya, Y., Jensen, R.A., Ishikawa, Y., Caveolin is an inhibitor of platelet-derived growth factor receptor signaling (1999) Exp Cell Res, 247, pp. 380-388
Engstrom, U., Engstrom, A., Ernlund, A., Westermark, B., Heldin, C.H., Identification of a peptide antagonist for platelet-derived growth factor (1992) J Biol Chem, 267, pp. 16581-16587
Brennand, D.M., Dennehy, U., Ellis, V., Scully, M.F., Tripathi, P., Kakkar, V.V., Identification of a cyclic peptide inhibitor of platelet-derived growth factor-BB receptor-binding and mitogen-induced DNA synthesis in human fibroblasts (1997) FEBS Lett, 413, pp. 70-74
Brennand, D.M., Scully, M.F., Kakkar, V.V., Patel, G., A cyclic peptide analogue of loop III of PDGF-BB causes apoptosis in human fibroblasts (1997) FEBS Lett, 419, pp. 166-170
Chiara, F., Bishayee, S., Heldin, C.H., Demoulin, J.B., Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail (2004) J Biol Chem, 279, pp. 19732-19738
Nagy, J.A., Dvorak, A.M., Dvorak, H.F., VEGF-A and the Induction of Pathological Angiogenesis. Annu Rev (2007) Pathol, 2, pp. 251-275
Park, J.E., Keller, G.A., Ferrara, N., The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF (1993) Mol Biol Cell, 4, pp. 1317-1326
Roth, D., Piekarek, M., Paulsson, M., Christ, H., Bloch, W., Krieg, T., Plasmin modulates vascular endothelial growth factor-Amediated angiogenesis during wound repair (2006) Am J Pathol, 168, pp. 670-684
Woolard, J., Wang, W.Y., Bevan, H.S., Qiu, Y., Morbidelli, L., Pritchard-Jones, R.O., VEGF165b, an inhibitory vascular endothelial growth factor splice variant: Mechanism of action, in vivo effect on angiogenesis and endogenous protein expression (2004) Cancer Res, 64, pp. 7822-7835
Maglione, D., Guerriero, V., Viglietto, G., Delli-Bovi, P., Persico, M.G., Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor (1991) Proc Natl Acad Sci USA, 88, pp. 9267-9271
Luttun, A., Tjwa, M., Carmeliet, P., Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): Novel therapeutic targets for angiogenic disorders (2002) Ann N Y Acad Sci, 979, pp. 80-93
Fischer, C., Jonckx, B., Mazzone, M., Zacchigna, S., Loges, S., Pattarini, L., Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels (2007) Cell, 131, pp. 463-475
Roy, H., Bhardwaj, S., Yla-Herttuala, S., Biology of vascular endothelial growth factors (2006) FEBS Lett, 580, pp. 2879-2887
Iyer, S., Acharya, K.R., Role of placenta growth factor in cardiovascular health (2002) Trends Cardiovasc Med, 12, pp. 128-134
Carmeliet, P., Moons, L., Luttun, A., Vincenti, V., Compernolle, V., De Mol, M., Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions (2001) Nat Med, 7, pp. 575-583
Hauser, S., Weich, H.A., A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta (1993) Growth Factors, 9, pp. 259-268
Ferrara, N., Gerber, H.P., LeCouter, J., The biology of VEGF and its receptors (2003) Nat Med, 9, pp. 669-676
Ferrara N. VEGF: An update on biological and therapeutic aspects. Curr Opin Biotechnol 2000
11: 617-24Ferrara, N., Davis-Smyth, T., The biology of vascular endothelial growth factor (1997) Endocr Rev, 18, pp. 4-25
Cross, M.J., Dixelius, J., Matsumoto, T., Claesson-Welsh, L., VEGF-receptor signal transduction (2003) Trends Biochem Sci, 28, pp. 488-494
Veikkola, T., Karkkainen, M., Claesson-Welsh, L., Alitalo, K., Regulation of angiogenesis via vascular endothelial growth factor receptors (2000) Cancer Res, 60, pp. 203-212
Hicklin, D.J., Ellis, L.M., Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis (2005) J Clin Oncol, 23, pp. 1011-1027
Hiratsuka, S., Minowa, O., Kuno, J., Noda, T., Shibuya, M., Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice (1998) Proc Natl Acad Sci USA, 95, pp. 9349-9354
Hattori, K., Heissig, B., Wu, Y., Dias, S., Tejada, R., Ferris, B., Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment (2002) Nat Med, 8, pp. 841-849
Autiero, M., Waltenberger, J., Communi, D., Kranz, A., Moons, L., Lambrechts, D., Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 (2003) Nat Med, 9, pp. 936-943
Kendall, R.L., Thomas, K.A., Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor (1993) Proc Natl Acad Sci USA, 90, pp. 10705-10709
Maynard, S.E., Min, J.Y., Merchan, J., Lim, K.H., Li, J., Mondal, S., Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia (2003) J Clin Invest, 111, pp. 649-658
Oliver, G., Alitalo, K., The lymphatic vasculature: Recent progress and paradigms (2005) Annu Rev Cell Dev Biol, 21, pp. 457-483
Alitalo, K., Tammela, T., Petrova, T.V., Lymphangiogenesis in development and human disease (2005) Nature, 438, pp. 946-953
Achen, M.G., Williams, R.A., Minekus, M.P., Thornton, G.E., Stenvers, K., Rogers, P.A., Localization of vascular endothelial growth factor D in malignant melanoma suggests a role in tumour angiogenesis (2001) J Pathol, 193, pp. 147-154
Valtola, R., Salven, P., Heikkila, P., Taipale, J., Joensuu, H., Rehn, M., VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer (1999) Am J Pathol, 154, pp. 1381-1390
Pellet-Many, C., Frankel, P., Jia, H., Zachary, I., Neuropilins: Structure, function and role in disease (2008) Biochem J, 411, pp. 211-226
Geretti, E., Shimizu, A., Klagsbrun, M., Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis (2008) Angiogenesis, 11, pp. 31-39
Muller, Y.A., Christinger, H.W., Keyt, B.A., de Vos, A.M., The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: Multiple copy flexibility and receptor binding (1997) Structure, 5, pp. 1325-1338
Muller, Y.A., Li, B., Christinger, H.W., Wells, J.A., Cunningham, B.C., de Vos, A.M., Vascular endothelial growth factor: Crystal structure and functional mapping of the kinase domain receptor binding site (1997) Proc Natl Acad Sci USA, 94, pp. 7192-7197
Pan, B., Li, B., Russell, S.J., Tom, J.Y., Cochran, A.G., Fairbrother, W.J., Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor (2002) J Mol Biol, 316, pp. 769-787
Wiesmann, C., Christinger, H.W., Cochran, A.G., Cunningham, B.C., Fairbrother, W.J., Keenan, C.J., Crystal structure of the complex between VEGF and a receptor-blocking peptide (1998) Biochemistry, 37, pp. 17765-17772
Muller, Y.A., Chen, Y., Christinger, H.W., Li, B., Cunningham, B.C., Lowman, H.B., VEGF and the Fab fragment of a humanized neutralizing antibody: Crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface (1998) Structure, 6, pp. 1153-1167
Starovasnik, M.A., Christinger, H.W., Wiesmann, C., Champe, M.A., de Vos, A.M., Skelton, N.J., Solution structure of the VEGF-binding domain of Flt-1: Comparison of its free and bound states (1999) J Mol Biol, 293, pp. 531-544
Wiesmann, C., Fuh, G., Christinger, H.W., Eigenbrot, C., Wells, J.A., de Vos, A.M., Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor (1997) Cell, 91, pp. 695-704
Christinger, H.W., Fuh, G., de Vos, A.M., Wiesmann, C., The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1 (2004) J Biol Chem, 279, pp. 10382-10388
McTigue, M.A., Wickersham, J.A., Pinko, C., Showalter, R.E., Parast, C.V., Tempczyk-Russell, A., Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: A key enzyme in angiogenesis (1999) Structure, 7, pp. 319-330
Ruch, C., Skiniotis, G., Steinmetz, M.O., Walz, T., Ballmer-Hofer, K., Structure of a VEGF-VEGF receptor complex determined by electron microscopy (2007) Nat Struct Mol Biol, 14, pp. 249-250
Keyt, B.A., Nguyen, H.V., Berleau, L.T., Duarte, C.M., Park, J., Chen, H., Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis (1996) J Biol Chem, 271, pp. 5638-5646
Lee, C.C., Kreusch, A., McMullan, D., Ng, K., Spraggon, G., Crystal structure of the human neuropilin-1 b1 domain (2003) Structure, 11, pp. 99-108
Appleton, B.A., Wu, P., Maloney, J., Yin, J., Liang, W.C., Stawicki, S., Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding (2007) Embo J, 26, pp. 4902-4912
Vander Kooi, C.W., Jusino, M.A., Perman, B., Neau, D.B., Bellamy, H.D., Leahy, D.J., Structural basis for ligand and heparin binding to neuropilin B domains (2007) Proc Natl Acad Sci USA, 104, pp. 6152-6157
Zachary, I., Vascular endothelial growth factor and anti-angiogenic peptides as therapeutic and investigational molecules (2003) IDrugs, 6, pp. 224-231
Ferrara, N., Hillan, K.J., Gerber, H.P., Novotny, W., Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer (2004) Nat Rev Drug Discov, 3, pp. 391-400
Underiner, T.L., Ruggeri, B., Gingrich, D.E., Development of vascular endothelial growth factor receptor (VEGFR) kinase inhibitors as anti-angiogenic agents in cancer therapy (2004) Curr Med Chem, 11, pp. 731-745
Sun, J., Blaskovich, M.A., Jain, R.K., Delarue, F., Paris, D., Brem, S., Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor (2004) Cancer Res, 64, pp. 3586-3592
Holash, J., Davis, S., Papadopoulos, N., Croll, S.D., Ho, L., Russell, M., VEGF-Trap: A VEGF blocker with potent antitumor effects (2002) Proc Natl Acad Sci USA, 99, pp. 11393-11398
Niethammer, A.G., Xiang, R., Becker, J.C., Wodrich, H., Pertl, U., Karsten, G., A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth (2002) Nat Med, 8, pp. 1369-1375
Takei, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S., Muramatsu, T., A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics (2004) Cancer Res, 64, pp. 3365-3370
Quesada, A.R., Munoz-Chapuli, R., Medina, M.A., Anti-angiogenic drugs: From bench to clinical trials (2006) Med Res Rev, 26, pp. 483-530
Jia, H., Jezequel, S., Lohr, M., Shaikh, S., Davis, D., Soker, S., Peptides encoded by exon 6 of VEGF inhibit endothelial cell biological responses and angiogenesis induced by VEGF (2001) Biochem Biophys Res Commun, 283, pp. 164-173
Bainbridge, J.W., Jia, H., Bagherzadeh, A., Selwood, D., Ali, R.R., Zachary, I., A peptide encoded by exon 6 of VEGF (EG3306) inhibits VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivo (2003) Biochem Biophys Res Commun, 302, pp. 793-799
Cheng, L., Jia, H., Lohr, M., Bagherzadeh, A., Holmes, D.I., Selwood, D., Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production (2004) J Biol Chem, 279, pp. 30654-30661
Giordano, R.J., Cardo-Vila, M., Lahdenranta, J., Pasqualini, R., Arap, W., Biopanning and rapid analysis of selective interactive ligands (2001) Nat Med, 7, pp. 1249-1253
Giordano, R.J., Anobom, C.D., Cardo-Vila, M., Kalil, J., Valente, A.P., Pasqualini, R., Structural basis for the interaction of a vascular endothelial growth factor mimic peptide motif and its corresponding receptors (2005) Chem Biol, 12, pp. 1075-1083
Binetruy-Tournaire, R., Demangel, C., Malavaud, B., Vassy, R., Rouyre, S., Kraemer, M., Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis (2000) Embo J, 19, pp. 1525-1533
Perret, G.Y., Starzec, A., Hauet, N., Vergote, J., Le Pecheur, M., Vassy, R., In vitro evaluation and biodistribution of a 99mTc-labeled anti-VEGF peptide targeting neuropilin-1 (2004) Nucl Med Biol, 31, pp. 575-581
Starzec, A., Vassy, R., Martin, A., Lecouvey, M., Di Benedetto, M., Crepin, M., Antiangiogenic and antitumor activities of peptide inhibiting the vascular endothelial growth factor binding to neuropilin-1 (2006) Life Sci, 79, pp. 2370-2381
Starzec, A., Ladam, P., Vassy, R., Badache, S., Bouchemal, N., Navaza, A., Structure-function analysis of the antiangiogenic ATWLPPR peptide inhibiting VEGF(165) binding to neuropilin-1 and molecular dynamics simulations of the ATWLPPR/neuropilin-1 complex (2007) Peptides, 28, pp. 2397-2402
Bae, D.G., Kim, T.D., Li, G., Yoon, W.H., Chae, C.B., Anti-flt1 peptide, a vascular endothelial growth factor receptor 1-specific hexapeptide, inhibits tumor growth and metastasis (2005) Clin Cancer Res, 11, pp. 2651-2661
von Wronski, M.A., Raju, N., Pillai, R., Bogdan, N.J., Marinelli, E.R., Nanjappan, P., Tuftsin binds neuropilin-1 through a sequence similar to that encoded by exon 8 of vascular endothelial growth factor (2006) J Biol Chem, 281, pp. 5702-5710
Qin, X., Wan, Y., Li, M., Xue, X., Wu, S., Zhang, C., Identification of a novel peptide ligand of human vascular endothelia growth factor receptor 3 for targeted tumour diagnosis and therapy (2007) J Biochem, 142, pp. 79-85
Shrivastava, A., von Wronski, M.A., Sato, A.K., Dransfield, D.T., Sexton, D., Bogdan, N., A distinct strategy to generate high-affinity peptide binders to receptor tyrosine kinases (2005) Protein Eng Des Sel, 18, pp. 417-424
Goncalves, V., Gautier, B., Coric, P., Bouaziz, S., Lenoir, C., Garbay, C., Rational design, structure, and biological evaluation of cyclic peptides mimicking the vascular endothelial growth factor (2007) J Med Chem, 50, pp. 5135-5146
Taylor, A.P., Goldenberg, D.M., Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts (2007) Mol Cancer Ther, 6, pp. 524-531
Udugamasooriya, D.G., Dineen, S.P., Brekken, R.A., Kodadek, T., A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity (2008) J Am Chem Soc, 130, pp. 5744-5752
Albini, A., Soldi, R., Giunciuglio, D., Giraudo, E., Benelli, R., Primo, L., The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells (1996) Nat Med, 2, pp. 1371-1375
D'Andrea, L.D., Iaccarino, G., Fattorusso, R., Sorriento, D., Carannante, C., Capasso, D., Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (2005) Proc Natl Acad Sci USA, 102, pp. 14215-14220
Dudar, G.K., D'Andrea, L.D., Di Stasi, R., Pedone, C., Wallace, J.L., A Vascular Endothelial Growth Factor Mimetic Accelerates Gastric Ulcer Healing in an iNOS-Dependent Manner (2008) Am J Physiol, , Gastrointest Liver Physiol
Waslif, J., (2004) Angiogenesis Inhibitors and Stimulators:tHe Emergence of a New Market
Jacobs, J., Combating cardiovascular disease with angiogenic therapy (2007) Drug Discov Today, 12, pp. 1040-1045
Kerbel, R., Folkman, J., Clinical translation of angiogenesis inhibitors (2002) Nat Rev Cancer, 2, pp. 727-739
Featherstone, J., Griffiths, S., From the analyst's couch. Drugs that target angiogenesis (2002) Nat Rev Drug Discov, 1, pp. 413-414
Cristofanilli, M., Charnsangavej, C., Hortobagyi, G.N., Angiogenesis modulation in cancer research: Novel clinical approaches (2002) Nat Rev Drug Discov, 1, pp. 415-426
Ferrara, N., Alitalo, K., Clinical applications of angiogenic growth factors and their inhibitors (1999) Nat Med, 5, pp. 1359-1364
Choe, Y.S., Lee, K.H., Targeted in vivo imaging of angiogenesis: Present status and perspectives (2007) Curr Pharm Des, 13, pp. 17-31
Ferrara, N., Mass, R.D., Campa, C., Kim, R., Targeting VEGF-A to treat cancer and age-related macular degeneration (2007) Annu Rev Med, 58, pp. 491-504
Million, R.P., Therapeutic area crossroads:aNti-angiogenesis (2008) Nature Rev. Drug Discov, 7, pp. 115-116
Simons, M., Ware, J.A., Therapeutic angiogenesis in cardiovascular disease (2003) Nat Rev Drug Discov, 2, pp. 863-871
Weis, S.M., Cheresh, D.A., Pathophysiological consequences of VEGF-induced vascular permeability (2005) Nature, 437, pp. 497-504
Lee, C.G., Link, H., Baluk, P., Homer, R.J., Chapoval, S., Bhandari, V., Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung (2004) Nat Med, 10, pp. 1095-1103
Molin, D., Post, M.J., Therapeutic angiogenesis in the heart: Protect and serve (2007) Curr Opin Pharmacol, 7, pp. 158-163
Emanueli, C., Madeddu, P., Changing the logic of therapeutic angiogenesis for ischemic disease (2005) Trends Mol Med, 11, pp. 207-216
Hetian, L., Ping, A., Shumei, S., Xiaoying, L., Luowen, H., Jian, W., A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor (2002) J Biol Chem, 277, pp. 43137-43142
Zilberberg, L., Shinkaruk, S., Lequin, O., Rousseau, B., Hagedorn, M., Costa, F., Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor (2003) J Biol Chem, 278, pp. 35564-35573
El-Mousawi, M., Tchistiakova, L., Yurchenko, L., Pietrzynski, G., Moreno, M., Stanimirovic, D., A vascular endothelial growth factor high affinity receptor 1-specific peptide with antiangiogenic activity identified using a phage display peptide library (2003) J Biol Chem, 278, pp. 46681-46691
An, P., Lei, H., Zhang, J., Song, S., He, L., Jin, G., Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library (2004) Int J Cancer, 111, pp. 165-173
Peptides targeting angiogenesis related growth factor receptors
Growth factors (GFs) are extracellular signaling polypeptides regulating cell proliferation, differentiation and survival. They exert a wide spectrum of biological activities selectively binding to and activating specific membrane receptors which then transfer the message to cell interior inducing specific biochemical pathways. GFs are especially involved in the regulation of angiogenesis, a physiological process underlining several pathologies. Molecules able to modulate angiogenesis, interfering with the molecular recognition between a GF and its receptor, have a big pharmacologic interest. Either GF and the receptor are potential drug target. Peptides are useful molecules to develop new lead compounds disrupting protein-protein interface for pharmacological applications. In this review we describe peptides targeting the receptors of the pro-angiogenic growth factors FGF, PDGF and VEGF. The biological function and the structure of each growth factor/receptor system are discussed, as well as the molecular interaction between peptides and the receptors. Finally, we highlight the pharmacological and diagnostic applications of these peptides in angiogenesis related diseases. © 2009 Bentham Science Publishers Ltd.
Growth factors (GFs) are extracellular signaling polypeptides regulating cell proliferation, differentiation and survival. They exert a wide spectrum of biological activities selectively binding to and activating specific membrane receptors which then transfer the message to cell interior inducing specific biochemical pathways. GFs are especially involved in the regulation of angiogenesis, a physiological process underlining several pathologies. Molecules able to modulate angiogenesis, interfering with the molecular recognition between a GF and its receptor, have a big pharmacologic interest. Either GF and the receptor are potential drug target. Peptides are useful molecules to develop new lead compounds disrupting protein-protein interface for pharmacological applications. In this review we describe peptides targeting the receptors of the pro-angiogenic growth factors FGF, PDGF and VEGF. The biological function and the structure of each growth factor/receptor system are discussed, as well as the molecular interaction between peptides and the receptors. Finally, we highlight the pharmacological and diagnostic applications of these peptides in angiogenesis related diseases. © 2009 Bentham Science Publishers Ltd.
Peptides targeting angiogenesis related growth factor receptors
Peptides targeting angiogenesis related growth factor receptors
Other filter: ([btitle,keywords] "Angiogenesis" OR [bt ...
Fasano M, Perri F, Della Corte CM, Di Liello R, Della Vittoria Scarpati G, Cascella M, Ottaiano A, Ciardiello F, Solla R
* Translational Insights and New Therapeutic Perspectives in Head and Neck Tumors (10 views)
Biomedicines (ISSN: 2227-9059linking), 2021 Aug 19; 9(8): N/D-N/D.
Impact Factor: 4.757
View Export to BibTeX Export to EndNote
Miro C, Nappi A, Cicatiello AG, Di Cicco E, Sagliocchi S, Murolo M, Belli V, Troiani T, Albanese S, Amiranda S, Zavacki AM, Stornaiuolo M, Mancini M, Salvatore D, Dentice M
* Thyroid Hormone Enhances Angiogenesis and the Warburg Effect in Squamous Cell Carcinomas (12 views)
Cancers (ISSN: 2072-6694linking), 2021 Jun 1; 13(11): N/D-N/D.
Impact Factor: 6.126
View Export to BibTeX Export to EndNote
Montano C, Auletta L, Greco A, Costanza D, Coluccia P, Del Prete C, Meomartino L, P , Pasolini M
* The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data (62 views)
Animals (ISSN: 2076-2615electronic, 2076-2615linking), 2021 Mar 12; 11(3): N/D-N/D.
Impact Factor: 2.323
View Export to BibTeX Export to EndNote
Capasso D, Del Gatto A, Comegna D, Russo L, Fattorusso R, Saviano M, Di Gaetano S, Zaccaro L
* Selective Targeting of αvβ5 Integrin in HepG2 Cell Line by RGDechi15D Peptide (108 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2020 Sep 19; 25(18): N/D-N/D.
Impact Factor: 3.267
View Export to BibTeX Export to EndNote
Fagoonee S, Pellicano R
* Promises of Fibroblast Growth Factor Receptor-Directed Therapy in Tailored Cancer Treatment (32 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Aug 8; 9(8): N/D-N/D.
Impact Factor: 6.78
View Export to BibTeX Export to EndNote
Nawaz MI, Rezzola S, Tobia C, Coltrini D, Belleri M, Mitola S, Corsini M, Sandomenico A, Caporale A, Ruvo M, Presta M
* D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor (71 views)
Angiogenesis (ISSN: 0969-6970linking), 2020 Aug; 23(3): 357-369.
Impact Factor: 9.78
View Export to BibTeX Export to EndNote
Tarallo V, Iaccarino E, Cicatiello V, Sanna R, Ruvo M, De Falco S
* Oral Delivery of a Tetrameric Tripeptide Inhibitor of VEGFR1 Suppresses Pathological Choroid Neovascularization (195 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 9; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
View Export to BibTeX Export to EndNote
Di Stasi R, Diana D, De Rosa L, Fattorusso R, D'Andrea LD
* Biochemical and Conformational Characterization of Recombinant VEGFR2 Domain "7" (226 views)
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Nov; 61(11): 860-872.
Impact Factor: 2.275
View Export to BibTeX Export to EndNote
Cimmino I, Margheri F, Prisco F, Perruolo G, D'Esposito V, Laurenzana A, Fibbi G, Paciello O, Doti N, Ruvo M, Miele C, Beguinot F, Formisano P, Oriente F
* Prep1 regulates angiogenesis through a PGC-1alpha-mediated mechanism (219 views)
Faseb J (ISSN: 0892-6638linking), 2019 Oct 15; 33(12): 13893-13904.
Impact Factor: 5.391
View Export to BibTeX Export to EndNote
Conte C, Moret F, Esposito D, Dal Poggetto G, Avitabile C, Ungaro F, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Biodegradable nanoparticles exposing a short anti-FLT1 peptide as antiangiogenic platform to complement docetaxel anticancer activity (214 views)
Mater Sci Eng C Mater Biol Appl (ISSN: 0928-4931linking), 2019 Sep; 102: 876-886.
Impact Factor: 5.08
View Export to BibTeX Export to EndNote
Wang L, Coric P, Broussy S, Di Stasi R, Zhou L, D'Andrea LD, Ji L, Vidal M, Bouaziz S, Liu WQ
* Structural studies of the binding of an antagonistic cyclic peptide to the VEGFR1 domain "2" (224 views)
Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254, 1768-3254electronic), 2019 May 1; 169: 65-75.
Impact Factor: 2.882
View Export to BibTeX Export to EndNote
Di Stasi R, De Rosa L, Diana D, Fattorusso R, D'Andrea LD
* Human Recombinant VEGFR2D4 Biochemical Characterization to Investigate Novel Anti-VEGFR2D4 Antibodies for Allosteric Targeting of VEGFR2 (287 views)
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Apr 26; 61(7): 513-520.
Impact Factor: 2.275
View Export to BibTeX Export to EndNote
Korotkyi OH, Vovk AA, Dranitsina AS, Falalyeyeva TM, Dvorshchenko KO, Fagoonee S, Ostapchenko LI
* The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis (247 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2019 Apr 1; 110(5): 419-424.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
De Simone G
* Targeted treatment of anaerobic cancer. Patent evaluation of US2016279084 and US2017056350 (225 views)
Expert Opin Ther Pat (ISSN: 1744-7674electronic, 1354-3776linking), 2019 Jan; 29(1): 1-6.
Impact Factor: 3.699
View Export to BibTeX Export to EndNote
Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (231 views)
Front Mol Neurosci (ISSN: 1662-5099, 1662-5099linking, 1662-5099electronic), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Giuffrida ML, Copani A, Rizzarelli E
* A promising connection between BDNF and Alzheimer's disease (249 views)
Aging (ISSN: 1945-4589linking), 2018 Aug 6; 10(8): 1791-1792.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Ferrucci V, De Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson L, Carotenuto M, Liguori L, Verrico A, Quaglietta L, Errico ME, Del Monaco V, D'Argenio V, Tirone F, Mastronuzzi A, Donofrio V, Giangaspero F, Picard D, Remke M, Garzia L, Daniels C, Delattre O, Swartling FJ, Weiss WA, Salvatore F, Fattorusso R, Chesler L, Taylor MD, Cinalli G, Zollo M
* Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-beta-OTX2-SNAIL via PTEN inhibition (930 views)
Brain (ISSN: 1460-2156electronic, 0006-8950linking), 2018 May 1; 141(5): 1300-1319.
Impact Factor: 9.915
View Export to BibTeX Export to EndNote
Pietropaolo A, Magri A, Greco V, Losasso V, La Mendola D, Sciuto S, Carloni P, Rizzarelli E
* Binding of Zn(II) to Tropomyosin Receptor Kinase A in Complex with Its Cognate Nerve Growth Factor: Insights from Molecular Simulation and in Vitro Essays (233 views)
Acs Chem Neurosci (ISSN: 1948-7193electronic, 1948-7193linking), 2018 Jan 12; N/D: N/D-N/D.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
De Rosa L, Di Stasi R, D'Andrea LD
* Pro-angiogenic peptides in biomedicine (473 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
View Export to BibTeX Export to EndNote
Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
* VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (337 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(44): 11461-11466.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (538 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
View Export to BibTeX Export to EndNote
Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, Mussano F, Carossa S, Silengo L, Altruda F, Merlo GR, Munaron L, Tolosano E
* Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis (200 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic), 2017 Dec 11; N/D: N/D-N/D.
Impact Factor: 8
View Export to BibTeX Export to EndNote
Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E
* Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (727 views) (PDF 197 views)
Aging Cell (ISSN: 1474-9726, 1474-9718linking), 2017 Nov 01; 17(1): N/D-N/D.
Impact Factor: 7.627
View Export to BibTeX Export to EndNote
Crich SG, Terreno E, Aime S
* Nano-sized and other improved reporters for magnetic resonance imaging of angiogenesis (252 views)
Adv Drug Deliver Rev (ISSN: 0169-409x), 2017 Sep 15; 119: 61-72.
Impact Factor: 13.66
View Export to BibTeX Export to EndNote
Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A
* Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer (691 views) (PDF 210 views)
Theranostics (ISSN: 1838-7640, 1838-7640electronic), 2017 Aug 22; 7(14): 3595-3607.
Impact Factor: 8.537
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma C, Quarantelli M, Carotenuto A, Pivonello C, Moccia M, Cianflone A, Marsili A, Puorro G, Sacca F, Russo CV, De Luca Picione C, Ausiello F, Colao A, Brescia Morra V
* Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon beta-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis (266 views)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic, 1351-5101linking), 2017 Feb; 24(2): 446-449.
Impact Factor: 4.621
View Export to BibTeX Export to EndNote
Musumeci D, Platella C, Riccardi C, Moccia F, Montesarchio D
* Fluorescence sensing using DNA Aptamers in cancer research and clinical diagnostics (273 views)
Cancers (ISSN: 2072-6694, 2072-6694linking), 2017; 9(12): N/D-N/D.
Impact Factor: 5.326
View Export to BibTeX Export to EndNote
Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (365 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Dec 28; 8(6): 10007-10024.
Impact Factor: 5.168
View Export to BibTeX Export to EndNote
Consolino L, Longo DL, Sciortino M, Dastru W, Cabodi S, Giovenzana GB, Aime S
* Assessing tumor vascularization as a potential biomarker of imatinib resistance in gastrointestinal stromal tumors by dynamic contrast-enhanced magnetic resonance imaging (263 views)
Gastric Cancer (ISSN: 1436-3291, 1436-3291linking), 2016 Dec 19; 20(4): 629-639.
Impact Factor: 5.454
View Export to BibTeX Export to EndNote
Lanza V, Travaglia A, Malgieri G, Fattorusso R, GrassoG, Di Natale G, Zito V, Arena G, Milardi D, Rizzarelli E
* Ubiquitin Associates with the N-Terminal Domain of Nerve Growth Factor: The Role of Copper(II) Ions (279 views) (PDF 172 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Dec 05; 22(49): 17767-17775.
Impact Factor: 5.317
View Export to BibTeX Export to EndNote
La Mendola D, Arnesano F, Hansson O, Giacomelli C, Calo V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E
* Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity (392 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2016 Jan 20; 8(1): 118-124.
Impact Factor: 3.975
View Export to BibTeX Export to EndNote
Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (308 views)
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
View Export to BibTeX Export to EndNote
Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J
* Human IgG1 antibodies suppress angiogenesis in a target-independent manner (557 views)
Signal Transduct Target Ther (ISSN: 2059-3635print), 2016; 1: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Di Stasi R, De Rosa L, Romanelli A, D'Andrea LD
* Peptides Interacting with Growth Factor Receptors Regulating Angiogenesis (350 views)
Frontiers In Medicinal Chemistry, 2016; 9: 103-160.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Miceli M, Dell'Aversana C, Russo R, Rega C, Cupelli L, Ruvo M, Altucci L, Chambery A
* Secretome profiling of cytokines and growth factors reveals that neuro-glial differentiation is associated with the down-regulation of Chemokine Ligand 2 (MCP-1/CCL2) in amniotic fluid derived-mesenchymal progenitor cells (467 views)
Proteomics (ISSN: 1615-9853), 2016; 16(4): 674-688.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Grasso G, Santoro AM, Magrì A, La Mendola D, Tomasello MF, Zimbone S, Rizzarelli E
* The Inorganic Perspective of VEGF: Interactions of Cu2 + with Peptides Encompassing a Recognition Domain of the VEGF Receptor (432 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 159: 149-158.
Impact Factor: 3.348
View Export to BibTeX Export to EndNote
De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (653 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
View Export to BibTeX Export to EndNote
Pignataro G, Ziaco B, Tortiglione A, Gala R, Cuomo O, Vinciguerra A, Lapi D, Mastantuono T, Anzilotti S, D'Andrea LD, Pedone C, Di Renzo G, Annunziato L, Cataldi M
* Neuroprotective Effect of VEGF-Mimetic Peptide QK in Experimental Brain Ischemia Induced in Rat by Middle Cerebral Artery Occlusion (286 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2015 Sep 16; 6(9): 1517-1525.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (526 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (571 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
View Export to BibTeX Export to EndNote
Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (422 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
View Export to BibTeX Export to EndNote
Ciccarelli M, Rusciano MR, Sorriento D, Maione AS, Soprano M, Iaccarino G, Illario M
* Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis (237 views)
Journal Of Cancer Therapy (ISSN: 2151-1934), 2015 Feb 11; 6: 199-212.
Impact Factor: 0.56
View Export to BibTeX Export to EndNote
Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
* Functional Binding Surface Of A Beta-Hairpin Vegf Receptor Targeting Peptide Determined By Nmr Spectroscopy In Living Cells (444 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 2; 21(1): 91-95.
Impact Factor: 5.771
View Export to BibTeX Export to EndNote
Travaglia A, Pietropaolo A, Di Martino R, Nicoletti VG, La Mendola D, Calissano P, Rizzarelli E
* A Small Linear Peptide Encompassing the NGF N-Terminus Partly Mimics the Biological Activities of the Entire Neurotrophin in PC12 Cells (337 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic, 1948-7193linking), 2015; 6(8): 1379-1392.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S
* Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment (488 views)
Magn Reson Imaging (ISSN: 0730-725x), 2015; 33(6): 725-736.
Impact Factor: 1.98
View Export to BibTeX Export to EndNote
Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (409 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (513 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2014 Sep 15; 20(18): 4806-4815.
Impact Factor: 8.722
View Export to BibTeX Export to EndNote
Carriero MV, Bifulco K, Minopoli M, Lista L, Maglio O, Mele L, Di Carluccio G, De Rosa M, Pavone V
* UPARANT: a urokinase receptor-derived peptide inhibitor of VEGF-driven angiogenesis with enhanced stability and in vitro and in vivo potency (467 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic), 2014 May; 13(5): 1092-1104.
Impact Factor: 5.683
View Export to BibTeX Export to EndNote
Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (571 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
View Export to BibTeX Export to EndNote
Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (768 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
View Export to BibTeX Export to EndNote
Forte G, Travaglia A, Magrì A, Satriano C, La Mendola D
* Adsorption of NGF and BDNF derived peptides on gold surfaces (492 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2014; 16(4): 1536-1544.
Impact Factor: 4.493
View Export to BibTeX Export to EndNote
Calce E, Sandomenico A, Saviano M, Ruvo M, De Luca S
* Cysteine Co-Oxidation Process Driven By Native Peptide Folding: An Example On Her2 Receptor Model System (366 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2014; 46(5): 1197-1206.
Impact Factor: 3.293
View Export to BibTeX Export to EndNote
De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (508 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014; 73: 210-216.
Impact Factor: 3.447
View Export to BibTeX Export to EndNote
Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (458 views)
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
Impact Factor: 0.635
View Export to BibTeX Export to EndNote
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1653 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
View Export to BibTeX Export to EndNote
Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
* Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (698 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Nov 7; 4(11): e911-e911.
Impact Factor: 5.177
View Export to BibTeX Export to EndNote
Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
* Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice (481 views)
Bmc Med Imaging (ISSN: 1471-2342, 1471-2342electronic), 2013 Sep 12; 13(1): 31-31.
Impact Factor: 0.983
View Export to BibTeX Export to EndNote
Diana D, Di Stasi R, De Rosa L, Isernia C, D'Andrea LD, Fattorusso R
* Structural investigation of the VEGF receptor interaction with a helical antagonist peptide (399 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 214-219.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (438 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
View Export to BibTeX Export to EndNote
Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (447 views)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
Impact Factor: 1.045
View Export to BibTeX Export to EndNote
Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (338 views)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
View Export to BibTeX Export to EndNote
Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (471 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
View Export to BibTeX Export to EndNote
Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (506 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1054 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
View Export to BibTeX Export to EndNote
Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (488 views)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
View Export to BibTeX Export to EndNote
Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (603 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
View Export to BibTeX Export to EndNote
Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (488 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (626 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Iiritano S, Chiefari E, Ventura V, Arcidiacono B, Possidente K, Nocera A, Nevolo MT, Fedele M, Greco A, Greco M, Brunetti G, Fusco A, Foti D, Brunetti A
* The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake (690 views)
Molecular Endocrinology (ISSN: 0888-8809, 1944-9917electronic), 2012 Sep; 26(9): 1578-1589.
Impact Factor: 4.746
View Export to BibTeX Export to EndNote
Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (367 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
Impact Factor: 2.406
View Export to BibTeX Export to EndNote
Riccio A, Cubellis MV
* Gain of function in CDKN1C (503 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
View Export to BibTeX Export to EndNote
Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (382 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Santoro AM, Nicoletti VG, Rizzarelli E
* Copper(II) interaction with peptide fragments of histidine-proline-rich glycoprotein: Speciation, stability and binding details (404 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 59-69.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (522 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
* Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (448 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 7; 7(5): e35774-e35774.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (614 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (525 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (777 views)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
View Export to BibTeX Export to EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (972 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (423 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
View Export to BibTeX Export to EndNote
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (517 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
View Export to BibTeX Export to EndNote
Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Gasperi M, Prinster A, Vacca G, Pivonello C, Orefice G, Colao A, Morra VB
* Insulin-like growth factor (IGF)-I and IGF-binding protein-3 serum levels in relapsing-remitting and secondary progressive multiple sclerosis patients (351 views)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic, 1351-5101linking), 2011 Dec; 18(12): 1402-1406.
Impact Factor: 3.692
View Export to BibTeX Export to EndNote
Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (523 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
View Export to BibTeX Export to EndNote
Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (562 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Troise F, Monti M, Merlino A, Cozzolino F, Fedele C, Russo Krauss I, Sica F, Pucci P, D'Alessio G, De Lorenzo C
* A novel ErbB2 epitope targeted by human antitumor immunoagents (391 views)
Febs Journal (ISSN: 1742-464x), 2011 Apr; 278(7): 1156-1166.
Impact Factor: 3.79
View Export to BibTeX Export to EndNote
Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E
* The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor (498 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Mar 21; 17(13): 3726-3738.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (538 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
View Export to BibTeX Export to EndNote
Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (455 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (496 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Ruggiero A, Squeglia F, Pirone L, Correale S, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis (407 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Jan 1; 67(1): 164-168.
Impact Factor: 0.506
View Export to BibTeX Export to EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (368 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
View Export to BibTeX Export to EndNote
Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (480 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (577 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
View Export to BibTeX Export to EndNote
Stanzione F, Esposito L, Paladino A, Pedone C, Morelli G, Vitagliano L
* Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors (455 views)
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2010 Oct 6; 99(7): 2273-2278.
Impact Factor: 4.218
View Export to BibTeX Export to EndNote
D'Andrea LD, Romanelli A, Di Stasi R, Pedone C
* Bioinorganic aspects of angiogenesis (496 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Sep 7; 39(33): 7625-7636.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (771 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
View Export to BibTeX Export to EndNote
Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (597 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (617 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
View Export to BibTeX Export to EndNote
Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (511 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (489 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (596 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (461 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
View Export to BibTeX Export to EndNote
Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis (348 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2010 Jan; 17(1): 70-73.
Impact Factor: 1.849
View Export to BibTeX Export to EndNote
Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* VEGFR1(D2) in drug discovery: Expression and molecular characterization (352 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010; 94(6): 800-809.
Impact Factor: 2.572
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma MC, Quarantelli M, Ventrella G, Prinster A, Vacca G, Orefice G, Colao AM, Morra VB
* Serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in relapsing and secondary progressive IFN beta treated MS patients (266 views)
Journal Of The Neurological Sciences (ISSN: 0022-510x), 2009 Oct; 285: N/D-N/D.
Impact Factor: 2.324
View Export to BibTeX Export to EndNote
Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (610 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma C, Quarantelli M, Gasperi M, Ventrella G, Prinster A, Vacca G, Orefice G, Colao A, Morra VB
* Serum levels of insulin like growth factor-1 and insulin like growth factor binding protein-3 in relapsing and secondary progressive multiple sclerosis (361 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2009 Sep; 15(9): 1402-1406.
Impact Factor: 3.279
View Export to BibTeX Export to EndNote
Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
* In vivo properties of the proangiogenic peptide QK (415 views)
J Transl Med (ISSN: 1479-5876, 1479-5876electronic, 1479-5876linking), 2009 Jun 8; 7: 41-41.
Impact Factor: 3.407
View Export to BibTeX Export to EndNote
Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (403 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
View Export to BibTeX Export to EndNote
Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (456 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, De Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, De Franciscis V
* Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (448 views)
Oncology (ISSN: 0030-2414), 2009; 77(6): 378-384.
Impact Factor: 2.112
View Export to BibTeX Export to EndNote
Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (401 views)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
View Export to BibTeX Export to EndNote
Chambery A, Vissers JPC, Langridge JI, Lonardo E, Minchiotti G, Ruvo M, Parente A
* Qualitative and quantitative proteomic profiling of cripto-1- embryonic stem cells by means of accurate mass LC-MS analysis (1015 views)
J Proteome Res (ISSN: 1535-3893), 2009; 8(2): 1047-1058.
Impact Factor: 5.132
View Export to BibTeX Export to EndNote
Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (537 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (816 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
View Export to BibTeX Export to EndNote
Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D
* Angiogenesis modulation: identification of tetrameric tripeptide as inhibitor of VEGFR-1 by the screening of peptide combinatiorial libraries (351 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Di Stasi R, Capasso D, Diana D, Fattorusso R, Pedone C, D'Andrea LD
* Vascular Endothelial Growth Factor (VEGF) and its receptors: key regulators of angiogenesis (290 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
View Export to BibTeX Export to EndNote
Romano S, Mallardo M, Chiurazzi F, Bisogni R, D'Angelillo A, Liuzzi R, Compare G, Romano M
* The effect of FK506 on transforming growth factor beta signaling and apaptosis in chronic lymphocytic leukemia B cells (293 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 2008 Jul; 93(7): 1039-1048.
Impact Factor: 5.978
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (408 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
View Export to BibTeX Export to EndNote
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (462 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
View Export to BibTeX Export to EndNote
Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E
* A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats (657 views)
J Neurosci (ISSN: 0270-6474, 0270-0647, 1529-2401), 2008 Mar 12; 28(11): 2698-2709.
Impact Factor: 7.452
View Export to BibTeX Export to EndNote
Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (367 views)
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.
Impact Factor: 0.481
View Export to BibTeX Export to EndNote
Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2008; 14(14): 4164-4166.
Impact Factor: 5.454
View Export to BibTeX Export to EndNote
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
View Export to BibTeX Export to EndNote
Costantino V, De Rosa C, Fattorusso E, Imperatore C, Mangoni A, Irace C, Maffettone C, Capasso D, Malorni L, Palumbo R, Pedone C
* Oreacerebrosides: Bioactive cerebrosides with a triunsaturated sphingoid base from the sea star Oreaster reticulatus (262 views)
Eur J Org Chem (ISSN: 1434-193x), 2007 Nov; (31): 5277-5283.
Impact Factor: 2.914
View Export to BibTeX Export to EndNote
Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
View Export to BibTeX Export to EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (575 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
View Export to BibTeX Export to EndNote
Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (372 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
View Export to BibTeX Export to EndNote
Bianco MR, Cirillo G, Cavaliere C, Colangelo AM, Vitagliano L, Morelli G, Sarmientos P, Martegani E, Alberghina L, Papa M
* A new Nerve Growth Factor (NGF)-mimetic peptide reduces gliosis and is active on neuropathic pain in rats (316 views)
Neuron Glia Biology (ISSN: 1740-925x), 2007; 2: N/D-N/D.
Impact Factor: 6.636
View Export to BibTeX Export to EndNote
Calvanese L, Saporito A, Marasco D, D'Auria G, Minchiotti G, Pedone C, Paolillo L, Falcigno L, Ruvo M
* Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (444 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (363 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (690 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (828 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
View Export to BibTeX Export to EndNote
Del Gatto A, D'Andrea LD, Zaccaro L, Saviano M, Pedone C, Benedetti E
* Engineering Peptides In Angiogenesis (418 views)
Biopolymers, 2006; 0: 215-216.
Impact Factor: 2.288
View Export to BibTeX Export to EndNote
D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (651 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (422 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
View Export to BibTeX Export to EndNote
Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (388 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
View Export to BibTeX Export to EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (429 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
View Export to BibTeX Export to EndNote
Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (419 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Salvatore M, Fonti R
* New frontiers of nuclear medicine (455 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (378 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (328 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (428 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (479 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (303 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (329 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (287 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (317 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
View Export to BibTeX Export to EndNote
Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (452 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
View Export to BibTeX Export to EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
View Export to BibTeX Export to EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
Cytosine arabinoside increases the binding of 125I-labelled epidermal growth factor and 125I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor) mAb (236 views)
Cancer Immunol Immunother (ISSN: 0340-7004linking), 1993 Aug; 37 (3 ): 150-156.
Impact Factor: 4.293
View Export to BibTeX Export to EndNote
FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (446 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
View Export to BibTeX Export to EndNote
Maglione D, Guerriero V, Viglietto G, Ferraro MG, Aprelikova O, Alitalo K, Del Vecchio S, Lei KJ, Chou JY, Persico MG
Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14 (443 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 1993; 8(4): 925-931.
Impact Factor: 6.772
View Export to BibTeX Export to EndNote
Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (442 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
* Translational Insights and New Therapeutic Perspectives in Head and Neck Tumors (10 views)
Biomedicines (ISSN: 2227-9059linking), 2021 Aug 19; 9(8): N/D-N/D.
Impact Factor: 4.757
View Export to BibTeX Export to EndNote
Miro C, Nappi A, Cicatiello AG, Di Cicco E, Sagliocchi S, Murolo M, Belli V, Troiani T, Albanese S, Amiranda S, Zavacki AM, Stornaiuolo M, Mancini M, Salvatore D, Dentice M
* Thyroid Hormone Enhances Angiogenesis and the Warburg Effect in Squamous Cell Carcinomas (12 views)
Cancers (ISSN: 2072-6694linking), 2021 Jun 1; 13(11): N/D-N/D.
Impact Factor: 6.126
View Export to BibTeX Export to EndNote
Montano C, Auletta L, Greco A, Costanza D, Coluccia P, Del Prete C, Meomartino L, P , Pasolini M
* The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data (62 views)
Animals (ISSN: 2076-2615electronic, 2076-2615linking), 2021 Mar 12; 11(3): N/D-N/D.
Impact Factor: 2.323
View Export to BibTeX Export to EndNote
Capasso D, Del Gatto A, Comegna D, Russo L, Fattorusso R, Saviano M, Di Gaetano S, Zaccaro L
* Selective Targeting of αvβ5 Integrin in HepG2 Cell Line by RGDechi15D Peptide (108 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2020 Sep 19; 25(18): N/D-N/D.
Impact Factor: 3.267
View Export to BibTeX Export to EndNote
Fagoonee S, Pellicano R
* Promises of Fibroblast Growth Factor Receptor-Directed Therapy in Tailored Cancer Treatment (32 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Aug 8; 9(8): N/D-N/D.
Impact Factor: 6.78
View Export to BibTeX Export to EndNote
Nawaz MI, Rezzola S, Tobia C, Coltrini D, Belleri M, Mitola S, Corsini M, Sandomenico A, Caporale A, Ruvo M, Presta M
* D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor (71 views)
Angiogenesis (ISSN: 0969-6970linking), 2020 Aug; 23(3): 357-369.
Impact Factor: 9.78
View Export to BibTeX Export to EndNote
Tarallo V, Iaccarino E, Cicatiello V, Sanna R, Ruvo M, De Falco S
* Oral Delivery of a Tetrameric Tripeptide Inhibitor of VEGFR1 Suppresses Pathological Choroid Neovascularization (195 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 9; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
View Export to BibTeX Export to EndNote
Di Stasi R, Diana D, De Rosa L, Fattorusso R, D'Andrea LD
* Biochemical and Conformational Characterization of Recombinant VEGFR2 Domain "7" (226 views)
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Nov; 61(11): 860-872.
Impact Factor: 2.275
View Export to BibTeX Export to EndNote
Cimmino I, Margheri F, Prisco F, Perruolo G, D'Esposito V, Laurenzana A, Fibbi G, Paciello O, Doti N, Ruvo M, Miele C, Beguinot F, Formisano P, Oriente F
* Prep1 regulates angiogenesis through a PGC-1alpha-mediated mechanism (219 views)
Faseb J (ISSN: 0892-6638linking), 2019 Oct 15; 33(12): 13893-13904.
Impact Factor: 5.391
View Export to BibTeX Export to EndNote
Conte C, Moret F, Esposito D, Dal Poggetto G, Avitabile C, Ungaro F, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Biodegradable nanoparticles exposing a short anti-FLT1 peptide as antiangiogenic platform to complement docetaxel anticancer activity (214 views)
Mater Sci Eng C Mater Biol Appl (ISSN: 0928-4931linking), 2019 Sep; 102: 876-886.
Impact Factor: 5.08
View Export to BibTeX Export to EndNote
Wang L, Coric P, Broussy S, Di Stasi R, Zhou L, D'Andrea LD, Ji L, Vidal M, Bouaziz S, Liu WQ
* Structural studies of the binding of an antagonistic cyclic peptide to the VEGFR1 domain "2" (224 views)
Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254, 1768-3254electronic), 2019 May 1; 169: 65-75.
Impact Factor: 2.882
View Export to BibTeX Export to EndNote
Di Stasi R, De Rosa L, Diana D, Fattorusso R, D'Andrea LD
* Human Recombinant VEGFR2D4 Biochemical Characterization to Investigate Novel Anti-VEGFR2D4 Antibodies for Allosteric Targeting of VEGFR2 (287 views)
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Apr 26; 61(7): 513-520.
Impact Factor: 2.275
View Export to BibTeX Export to EndNote
Korotkyi OH, Vovk AA, Dranitsina AS, Falalyeyeva TM, Dvorshchenko KO, Fagoonee S, Ostapchenko LI
* The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis (247 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2019 Apr 1; 110(5): 419-424.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
De Simone G
* Targeted treatment of anaerobic cancer. Patent evaluation of US2016279084 and US2017056350 (225 views)
Expert Opin Ther Pat (ISSN: 1744-7674electronic, 1354-3776linking), 2019 Jan; 29(1): 1-6.
Impact Factor: 3.699
View Export to BibTeX Export to EndNote
Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F
* Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection? (231 views)
Front Mol Neurosci (ISSN: 1662-5099, 1662-5099linking, 1662-5099electronic), 2018 Nov 13; 11: 414-414.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Giuffrida ML, Copani A, Rizzarelli E
* A promising connection between BDNF and Alzheimer's disease (249 views)
Aging (ISSN: 1945-4589linking), 2018 Aug 6; 10(8): 1791-1792.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Ferrucci V, De Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson L, Carotenuto M, Liguori L, Verrico A, Quaglietta L, Errico ME, Del Monaco V, D'Argenio V, Tirone F, Mastronuzzi A, Donofrio V, Giangaspero F, Picard D, Remke M, Garzia L, Daniels C, Delattre O, Swartling FJ, Weiss WA, Salvatore F, Fattorusso R, Chesler L, Taylor MD, Cinalli G, Zollo M
* Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-beta-OTX2-SNAIL via PTEN inhibition (930 views)
Brain (ISSN: 1460-2156electronic, 0006-8950linking), 2018 May 1; 141(5): 1300-1319.
Impact Factor: 9.915
View Export to BibTeX Export to EndNote
Pietropaolo A, Magri A, Greco V, Losasso V, La Mendola D, Sciuto S, Carloni P, Rizzarelli E
* Binding of Zn(II) to Tropomyosin Receptor Kinase A in Complex with Its Cognate Nerve Growth Factor: Insights from Molecular Simulation and in Vitro Essays (233 views)
Acs Chem Neurosci (ISSN: 1948-7193electronic, 1948-7193linking), 2018 Jan 12; N/D: N/D-N/D.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
De Rosa L, Di Stasi R, D'Andrea LD
* Pro-angiogenic peptides in biomedicine (473 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
View Export to BibTeX Export to EndNote
Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
* VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (337 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(44): 11461-11466.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (538 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
View Export to BibTeX Export to EndNote
Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, Mussano F, Carossa S, Silengo L, Altruda F, Merlo GR, Munaron L, Tolosano E
* Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis (200 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic), 2017 Dec 11; N/D: N/D-N/D.
Impact Factor: 8
View Export to BibTeX Export to EndNote
Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E
* Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (727 views) (PDF 197 views)
Aging Cell (ISSN: 1474-9726, 1474-9718linking), 2017 Nov 01; 17(1): N/D-N/D.
Impact Factor: 7.627
View Export to BibTeX Export to EndNote
Crich SG, Terreno E, Aime S
* Nano-sized and other improved reporters for magnetic resonance imaging of angiogenesis (252 views)
Adv Drug Deliver Rev (ISSN: 0169-409x), 2017 Sep 15; 119: 61-72.
Impact Factor: 13.66
View Export to BibTeX Export to EndNote
Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A
* Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer (691 views) (PDF 210 views)
Theranostics (ISSN: 1838-7640, 1838-7640electronic), 2017 Aug 22; 7(14): 3595-3607.
Impact Factor: 8.537
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma C, Quarantelli M, Carotenuto A, Pivonello C, Moccia M, Cianflone A, Marsili A, Puorro G, Sacca F, Russo CV, De Luca Picione C, Ausiello F, Colao A, Brescia Morra V
* Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon beta-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis (266 views)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic, 1351-5101linking), 2017 Feb; 24(2): 446-449.
Impact Factor: 4.621
View Export to BibTeX Export to EndNote
Musumeci D, Platella C, Riccardi C, Moccia F, Montesarchio D
* Fluorescence sensing using DNA Aptamers in cancer research and clinical diagnostics (273 views)
Cancers (ISSN: 2072-6694, 2072-6694linking), 2017; 9(12): N/D-N/D.
Impact Factor: 5.326
View Export to BibTeX Export to EndNote
Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (365 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Dec 28; 8(6): 10007-10024.
Impact Factor: 5.168
View Export to BibTeX Export to EndNote
Consolino L, Longo DL, Sciortino M, Dastru W, Cabodi S, Giovenzana GB, Aime S
* Assessing tumor vascularization as a potential biomarker of imatinib resistance in gastrointestinal stromal tumors by dynamic contrast-enhanced magnetic resonance imaging (263 views)
Gastric Cancer (ISSN: 1436-3291, 1436-3291linking), 2016 Dec 19; 20(4): 629-639.
Impact Factor: 5.454
View Export to BibTeX Export to EndNote
Lanza V, Travaglia A, Malgieri G, Fattorusso R, GrassoG, Di Natale G, Zito V, Arena G, Milardi D, Rizzarelli E
* Ubiquitin Associates with the N-Terminal Domain of Nerve Growth Factor: The Role of Copper(II) Ions (279 views) (PDF 172 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Dec 05; 22(49): 17767-17775.
Impact Factor: 5.317
View Export to BibTeX Export to EndNote
La Mendola D, Arnesano F, Hansson O, Giacomelli C, Calo V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E
* Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity (392 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2016 Jan 20; 8(1): 118-124.
Impact Factor: 3.975
View Export to BibTeX Export to EndNote
Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (308 views)
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
View Export to BibTeX Export to EndNote
Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J
* Human IgG1 antibodies suppress angiogenesis in a target-independent manner (557 views)
Signal Transduct Target Ther (ISSN: 2059-3635print), 2016; 1: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Di Stasi R, De Rosa L, Romanelli A, D'Andrea LD
* Peptides Interacting with Growth Factor Receptors Regulating Angiogenesis (350 views)
Frontiers In Medicinal Chemistry, 2016; 9: 103-160.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Miceli M, Dell'Aversana C, Russo R, Rega C, Cupelli L, Ruvo M, Altucci L, Chambery A
* Secretome profiling of cytokines and growth factors reveals that neuro-glial differentiation is associated with the down-regulation of Chemokine Ligand 2 (MCP-1/CCL2) in amniotic fluid derived-mesenchymal progenitor cells (467 views)
Proteomics (ISSN: 1615-9853), 2016; 16(4): 674-688.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Grasso G, Santoro AM, Magrì A, La Mendola D, Tomasello MF, Zimbone S, Rizzarelli E
* The Inorganic Perspective of VEGF: Interactions of Cu2 + with Peptides Encompassing a Recognition Domain of the VEGF Receptor (432 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 159: 149-158.
Impact Factor: 3.348
View Export to BibTeX Export to EndNote
De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (653 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
View Export to BibTeX Export to EndNote
Pignataro G, Ziaco B, Tortiglione A, Gala R, Cuomo O, Vinciguerra A, Lapi D, Mastantuono T, Anzilotti S, D'Andrea LD, Pedone C, Di Renzo G, Annunziato L, Cataldi M
* Neuroprotective Effect of VEGF-Mimetic Peptide QK in Experimental Brain Ischemia Induced in Rat by Middle Cerebral Artery Occlusion (286 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2015 Sep 16; 6(9): 1517-1525.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (526 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (571 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
View Export to BibTeX Export to EndNote
Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (422 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
View Export to BibTeX Export to EndNote
Ciccarelli M, Rusciano MR, Sorriento D, Maione AS, Soprano M, Iaccarino G, Illario M
* Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis (237 views)
Journal Of Cancer Therapy (ISSN: 2151-1934), 2015 Feb 11; 6: 199-212.
Impact Factor: 0.56
View Export to BibTeX Export to EndNote
Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
* Functional Binding Surface Of A Beta-Hairpin Vegf Receptor Targeting Peptide Determined By Nmr Spectroscopy In Living Cells (444 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 2; 21(1): 91-95.
Impact Factor: 5.771
View Export to BibTeX Export to EndNote
Travaglia A, Pietropaolo A, Di Martino R, Nicoletti VG, La Mendola D, Calissano P, Rizzarelli E
* A Small Linear Peptide Encompassing the NGF N-Terminus Partly Mimics the Biological Activities of the Entire Neurotrophin in PC12 Cells (337 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic, 1948-7193linking), 2015; 6(8): 1379-1392.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S
* Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment (488 views)
Magn Reson Imaging (ISSN: 0730-725x), 2015; 33(6): 725-736.
Impact Factor: 1.98
View Export to BibTeX Export to EndNote
Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (409 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (513 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2014 Sep 15; 20(18): 4806-4815.
Impact Factor: 8.722
View Export to BibTeX Export to EndNote
Carriero MV, Bifulco K, Minopoli M, Lista L, Maglio O, Mele L, Di Carluccio G, De Rosa M, Pavone V
* UPARANT: a urokinase receptor-derived peptide inhibitor of VEGF-driven angiogenesis with enhanced stability and in vitro and in vivo potency (467 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic), 2014 May; 13(5): 1092-1104.
Impact Factor: 5.683
View Export to BibTeX Export to EndNote
Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (571 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
View Export to BibTeX Export to EndNote
Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (768 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
View Export to BibTeX Export to EndNote
Forte G, Travaglia A, Magrì A, Satriano C, La Mendola D
* Adsorption of NGF and BDNF derived peptides on gold surfaces (492 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2014; 16(4): 1536-1544.
Impact Factor: 4.493
View Export to BibTeX Export to EndNote
Calce E, Sandomenico A, Saviano M, Ruvo M, De Luca S
* Cysteine Co-Oxidation Process Driven By Native Peptide Folding: An Example On Her2 Receptor Model System (366 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2014; 46(5): 1197-1206.
Impact Factor: 3.293
View Export to BibTeX Export to EndNote
De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (508 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014; 73: 210-216.
Impact Factor: 3.447
View Export to BibTeX Export to EndNote
Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (458 views)
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
Impact Factor: 0.635
View Export to BibTeX Export to EndNote
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1653 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
View Export to BibTeX Export to EndNote
Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
* Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (698 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Nov 7; 4(11): e911-e911.
Impact Factor: 5.177
View Export to BibTeX Export to EndNote
Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
* Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice (481 views)
Bmc Med Imaging (ISSN: 1471-2342, 1471-2342electronic), 2013 Sep 12; 13(1): 31-31.
Impact Factor: 0.983
View Export to BibTeX Export to EndNote
Diana D, Di Stasi R, De Rosa L, Isernia C, D'Andrea LD, Fattorusso R
* Structural investigation of the VEGF receptor interaction with a helical antagonist peptide (399 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 214-219.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (438 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
View Export to BibTeX Export to EndNote
Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (447 views)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
Impact Factor: 1.045
View Export to BibTeX Export to EndNote
Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (338 views)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
View Export to BibTeX Export to EndNote
Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (471 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
View Export to BibTeX Export to EndNote
Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (506 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1054 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
View Export to BibTeX Export to EndNote
Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (488 views)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
View Export to BibTeX Export to EndNote
Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (603 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
View Export to BibTeX Export to EndNote
Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (488 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (626 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Iiritano S, Chiefari E, Ventura V, Arcidiacono B, Possidente K, Nocera A, Nevolo MT, Fedele M, Greco A, Greco M, Brunetti G, Fusco A, Foti D, Brunetti A
* The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake (690 views)
Molecular Endocrinology (ISSN: 0888-8809, 1944-9917electronic), 2012 Sep; 26(9): 1578-1589.
Impact Factor: 4.746
View Export to BibTeX Export to EndNote
Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (367 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
Impact Factor: 2.406
View Export to BibTeX Export to EndNote
Riccio A, Cubellis MV
* Gain of function in CDKN1C (503 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
View Export to BibTeX Export to EndNote
Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (382 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Santoro AM, Nicoletti VG, Rizzarelli E
* Copper(II) interaction with peptide fragments of histidine-proline-rich glycoprotein: Speciation, stability and binding details (404 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 59-69.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (522 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
* Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (448 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 7; 7(5): e35774-e35774.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (614 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (525 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (777 views)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
View Export to BibTeX Export to EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (972 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (423 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
View Export to BibTeX Export to EndNote
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (517 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
View Export to BibTeX Export to EndNote
Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Gasperi M, Prinster A, Vacca G, Pivonello C, Orefice G, Colao A, Morra VB
* Insulin-like growth factor (IGF)-I and IGF-binding protein-3 serum levels in relapsing-remitting and secondary progressive multiple sclerosis patients (351 views)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic, 1351-5101linking), 2011 Dec; 18(12): 1402-1406.
Impact Factor: 3.692
View Export to BibTeX Export to EndNote
Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (523 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
View Export to BibTeX Export to EndNote
Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (562 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Troise F, Monti M, Merlino A, Cozzolino F, Fedele C, Russo Krauss I, Sica F, Pucci P, D'Alessio G, De Lorenzo C
* A novel ErbB2 epitope targeted by human antitumor immunoagents (391 views)
Febs Journal (ISSN: 1742-464x), 2011 Apr; 278(7): 1156-1166.
Impact Factor: 3.79
View Export to BibTeX Export to EndNote
Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E
* The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor (498 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Mar 21; 17(13): 3726-3738.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (538 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
View Export to BibTeX Export to EndNote
Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (455 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (496 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Ruggiero A, Squeglia F, Pirone L, Correale S, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis (407 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Jan 1; 67(1): 164-168.
Impact Factor: 0.506
View Export to BibTeX Export to EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (368 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
View Export to BibTeX Export to EndNote
Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (480 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Calvanese L, Marasco D, Doti N, Saporito A, D'Auria G, Paolillo L, Ruvo M, Falcigno L
* Structural Investigations on the Nodal-Cripto Binding: A Theoretical and Experimental Approach (577 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Nov; 93(11): 1011-1021.
Impact Factor: 2.572
View Export to BibTeX Export to EndNote
Stanzione F, Esposito L, Paladino A, Pedone C, Morelli G, Vitagliano L
* Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors (455 views)
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2010 Oct 6; 99(7): 2273-2278.
Impact Factor: 4.218
View Export to BibTeX Export to EndNote
D'Andrea LD, Romanelli A, Di Stasi R, Pedone C
* Bioinorganic aspects of angiogenesis (496 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Sep 7; 39(33): 7625-7636.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (771 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
View Export to BibTeX Export to EndNote
Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (597 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (617 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
View Export to BibTeX Export to EndNote
Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (511 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (489 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (596 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (461 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
View Export to BibTeX Export to EndNote
Ruggiero A, Squeglia F, Esposito C, Marasco D, Pedone E, Pedone C, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis (348 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2010 Jan; 17(1): 70-73.
Impact Factor: 1.849
View Export to BibTeX Export to EndNote
Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* VEGFR1(D2) in drug discovery: Expression and molecular characterization (352 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010; 94(6): 800-809.
Impact Factor: 2.572
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma MC, Quarantelli M, Ventrella G, Prinster A, Vacca G, Orefice G, Colao AM, Morra VB
* Serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in relapsing and secondary progressive IFN beta treated MS patients (266 views)
Journal Of The Neurological Sciences (ISSN: 0022-510x), 2009 Oct; 285: N/D-N/D.
Impact Factor: 2.324
View Export to BibTeX Export to EndNote
Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (610 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
View Export to BibTeX Export to EndNote
Lanzillo R, Di Somma C, Quarantelli M, Gasperi M, Ventrella G, Prinster A, Vacca G, Orefice G, Colao A, Morra VB
* Serum levels of insulin like growth factor-1 and insulin like growth factor binding protein-3 in relapsing and secondary progressive multiple sclerosis (361 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2009 Sep; 15(9): 1402-1406.
Impact Factor: 3.279
View Export to BibTeX Export to EndNote
Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
* In vivo properties of the proangiogenic peptide QK (415 views)
J Transl Med (ISSN: 1479-5876, 1479-5876electronic, 1479-5876linking), 2009 Jun 8; 7: 41-41.
Impact Factor: 3.407
View Export to BibTeX Export to EndNote
Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (403 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
View Export to BibTeX Export to EndNote
Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (456 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, De Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, De Franciscis V
* Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (448 views)
Oncology (ISSN: 0030-2414), 2009; 77(6): 378-384.
Impact Factor: 2.112
View Export to BibTeX Export to EndNote
Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (401 views)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
View Export to BibTeX Export to EndNote
Chambery A, Vissers JPC, Langridge JI, Lonardo E, Minchiotti G, Ruvo M, Parente A
* Qualitative and quantitative proteomic profiling of cripto-1- embryonic stem cells by means of accurate mass LC-MS analysis (1015 views)
J Proteome Res (ISSN: 1535-3893), 2009; 8(2): 1047-1058.
Impact Factor: 5.132
View Export to BibTeX Export to EndNote
Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (537 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (816 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
View Export to BibTeX Export to EndNote
Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D
* Angiogenesis modulation: identification of tetrameric tripeptide as inhibitor of VEGFR-1 by the screening of peptide combinatiorial libraries (351 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Di Stasi R, Capasso D, Diana D, Fattorusso R, Pedone C, D'Andrea LD
* Vascular Endothelial Growth Factor (VEGF) and its receptors: key regulators of angiogenesis (290 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
View Export to BibTeX Export to EndNote
Romano S, Mallardo M, Chiurazzi F, Bisogni R, D'Angelillo A, Liuzzi R, Compare G, Romano M
* The effect of FK506 on transforming growth factor beta signaling and apaptosis in chronic lymphocytic leukemia B cells (293 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 2008 Jul; 93(7): 1039-1048.
Impact Factor: 5.978
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (408 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
View Export to BibTeX Export to EndNote
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (462 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
View Export to BibTeX Export to EndNote
Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E
* A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats (657 views)
J Neurosci (ISSN: 0270-6474, 0270-0647, 1529-2401), 2008 Mar 12; 28(11): 2698-2709.
Impact Factor: 7.452
View Export to BibTeX Export to EndNote
Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (367 views)
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.
Impact Factor: 0.481
View Export to BibTeX Export to EndNote
Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2008; 14(14): 4164-4166.
Impact Factor: 5.454
View Export to BibTeX Export to EndNote
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
View Export to BibTeX Export to EndNote
Costantino V, De Rosa C, Fattorusso E, Imperatore C, Mangoni A, Irace C, Maffettone C, Capasso D, Malorni L, Palumbo R, Pedone C
* Oreacerebrosides: Bioactive cerebrosides with a triunsaturated sphingoid base from the sea star Oreaster reticulatus (262 views)
Eur J Org Chem (ISSN: 1434-193x), 2007 Nov; (31): 5277-5283.
Impact Factor: 2.914
View Export to BibTeX Export to EndNote
Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
View Export to BibTeX Export to EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (575 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
View Export to BibTeX Export to EndNote
Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (372 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
View Export to BibTeX Export to EndNote
Bianco MR, Cirillo G, Cavaliere C, Colangelo AM, Vitagliano L, Morelli G, Sarmientos P, Martegani E, Alberghina L, Papa M
* A new Nerve Growth Factor (NGF)-mimetic peptide reduces gliosis and is active on neuropathic pain in rats (316 views)
Neuron Glia Biology (ISSN: 1740-925x), 2007; 2: N/D-N/D.
Impact Factor: 6.636
View Export to BibTeX Export to EndNote
Calvanese L, Saporito A, Marasco D, D'Auria G, Minchiotti G, Pedone C, Paolillo L, Falcigno L, Ruvo M
* Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (444 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Marasco D, Saporito A, Ponticelli S, Chambery A, De Falco S, Pedone C, Minchiotti G, Ruvo M
* Chemical synthesis of mouse Cripto CFC variants (363 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Sep 15; 64(3): 779-788.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (690 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (828 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
View Export to BibTeX Export to EndNote
Del Gatto A, D'Andrea LD, Zaccaro L, Saviano M, Pedone C, Benedetti E
* Engineering Peptides In Angiogenesis (418 views)
Biopolymers, 2006; 0: 215-216.
Impact Factor: 2.288
View Export to BibTeX Export to EndNote
D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (651 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (422 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
View Export to BibTeX Export to EndNote
Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (388 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
View Export to BibTeX Export to EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (429 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
View Export to BibTeX Export to EndNote
Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (419 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Salvatore M, Fonti R
* New frontiers of nuclear medicine (455 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (378 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (328 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (428 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (479 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (303 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (329 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (287 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
View Export to BibTeX Export to EndNote
Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (317 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
View Export to BibTeX Export to EndNote
Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (452 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
View Export to BibTeX Export to EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
View Export to BibTeX Export to EndNote
Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
Cytosine arabinoside increases the binding of 125I-labelled epidermal growth factor and 125I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor) mAb (236 views)
Cancer Immunol Immunother (ISSN: 0340-7004linking), 1993 Aug; 37 (3 ): 150-156.
Impact Factor: 4.293
View Export to BibTeX Export to EndNote
FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (446 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
View Export to BibTeX Export to EndNote
Maglione D, Guerriero V, Viglietto G, Ferraro MG, Aprelikova O, Alitalo K, Del Vecchio S, Lei KJ, Chou JY, Persico MG
Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14 (443 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 1993; 8(4): 925-931.
Impact Factor: 6.772
View Export to BibTeX Export to EndNote
Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (442 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
167 Records (155 excluding Abstracts).
Total impact factor: 814.782 (778.879 excluding Abstracts).
Total 5 year impact factor: 768.101 (732.366 excluding Abstracts).
Total impact factor: 814.782 (778.879 excluding Abstracts).
Total 5 year impact factor: 768.101 (732.366 excluding Abstracts).
14494 views. Last view on Tuesday 21 March 2023, 18:01:37
ibb.cnr.it
