Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation(519 views) Avitabile C, Saviano M, D'Andrea LD, Bianchi N, Fabbri E, Brognara E, Gambari R, Romanelli A
Artif Dna Pna Xnaartificial Dna Pna & Xna (ISSN: 1949-9096, 1949-0968, 1949-095x), 2012 Apr; 3(2): 88-96.
Keywords: Facs, Fluorescence, Mir-210, Pna, Pre-Mir, Thiazole Orange, Peptide, Peptide Nucleic Acid, Precursor Microrna, Rna Precursor, Unclassified Drug, Article, Cancer Cell Culture, Controlled Study, Drug Targeting, Fluorescence Analysis, Human, Human Cell, In Vitro Study, In Vivo Study, Rna Binding, Rna Interference, Rna Processing, Rna Synthesis, Base Sequence, Down-Regulation, Drug Effects, K562 Cells, Genetics, Metabolism, Chemical Synthesis, Chemistry, Pharmacology, Plicamycin, Mithramycin, Cell Strain K 562, Down Regulation, Nucleotide Sequence,
Affiliations: *** IBB - CNR ***
Università di Napoli Federico II, Dipartimento delle Scienze Biologiche, Napoli, Italy
Istituto di Cristallografia, CNR, Bari, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy
Università di Ferrara, Dipartimento di Biochimica e Biologia Molecolare, Ferrara, Italy
Universit di Napoli Federico II, Dipartimento delle Scienze Biologiche, Napoli, Italy
Universit di Ferrara, Dipartimento di Biochimica e Biologia Molecolare, Ferrara, Italy
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Fabani, M. M., Abreu-Goodger, C., Williams, D., Lyons, P. A., Torres, A. G., Smith, K. G., Efficient inhibition of miR-155 function in vivo by peptide nucleic acids (2010) Nucleic Acids Res, 38, pp. 4466-4475. , http: //dx. doi. org/10. 1093/nar/gkq160, PMID: 20223773
Hu, J., Corey, D. R., Inhibiting gene expression with peptide nucleic acid (PNA) -peptide conjugates that target chromosomal DNA (2007) Biochemistry, 46, pp. 759-7581. , http: //dx. doi. org/10. 1021/bi700230a, PMID: 17536840
D az-Moch n, J. J., Bialy, L., Watson, J., S nchez-Mart n, R. M., Bradley, M., Synthesis and cellular uptake of cell delivering PNA-peptide conjugates (2005) Chem Commun, pp. 3316-3318. , http: //dx. doi. org/10. 1039/b503777h, (Camb)
Mahon Jr., K. P., Ortiz-Meoz, R. F., Prestwich, E. G., Kelley, S. O., Photosensitized DNA cleavage promoted by amino acids (2003) Chem Commun, pp. 1956-1957. , (Camb)
Berthold, P. R., Shiraishi, T., Nielsen, P. E., Cellular delivery and antisense effects of peptide nucleic acid conjugated to polyethyleneimine via disulfide linkers (2010) Bioconjug Chem, 21, pp. 1933-1938. , http: //dx. doi. org/10. 1021/bc1003586, PMID: 20873710
Rasmussen, F. W., Bendifallah, N., Zachar, V., Shiraishi, T., Fink, T., Ebbesen, P., Evaluation of transfection protocols for unmodified and modified peptide nucleic acid (PNA) oligomers (2006) Oligonucleotides, 16, pp. 43-57. , http: //dx. doi. org/10. 1089/oli. 2006. 16. 43, PMID: 16584294
Kloosterman, W. P., Lagendijk, A. K., Ketting, R. F., Moulton, J. D., Plasterk, R. H., Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development (2007) PLoS Biol, 5, p. 203. , http: //dx. doi. org/10. 1371/journal. pbio. 0050203, PMID: 17676975
Jadhav, V. M., Scaria, V., Maiti, S., Antagomirzymes: Oligonucleotide enzymes that specifically silence microRNA function (2009) Angew Chem Int Ed Engl, 48, pp. 260-2557. , http: //dx. doi. org/10. 1002/anie. 200805521, PMID: 19229913
Burroughs, A. M., Kawano, M., Ando, Y., Daub, C. O., Hayashizaki, Y., Pre-miRNA profiles obtained through application of locked nucleic acids and deep sequencing reveals complex 5'/3' arm variation including concomitant cleavage and polyuridylation patterns (2012) Nucleic Acids Res, 40, pp. 1424-1437. , PMID: 22058130
(SICI) 1097-0282 (199807) 46: 1<39:: AID-BIP4>
3. 0. CO
Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation