Measurement of global drain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies(495 views) Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli E, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Paper type: Journal Article, Abstract, Conference,
Impact factor: 1.302, 5-year impact factor: 3.007
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Measurement of global drain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies
In 16 patients with probable Alzheimer's disease (AD; NINDS criteria, age range 56-78 years), gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) absolute and fractional volumes were measured with an unsupervised multiparametric post-processing segmentation method based on estimates of relaxation rates R1, R2 (R1 = 1/T1; R2 = 1/T2) and proton density [N(H)] from conventional spin-echo studies (Alfano et al, Magn, Reson. Med, 1997:37:84-93). Global brain atrophy, and GM and WM fractions significantly correlated with Mini-Mental Status Examination and Blessed Dement;Ia Scale scores. Compared with normals, brain compartments in AD patients showed decreased GM (-6.84 +/- 1.58%) and WNI fractions (-9.79 +/- 2.47%) and increased CSF fractions (+58.80 +/- 10.37%). Changes were more evident in early-onset AD patients. In AD, measurement of global brain atrophy obtained by a computerized procedure based on routine magnetic resonance studies could complement the information provided by neuropsychological tests for the assessment of disease severity. (C) 2000 Wiley-Liss, Inc.
Measurement of global drain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies