Bone marrow uptake of 99mTc-MIBI in patients with multiple myeloma(431 views) Fonti R, Del Vecchio S, Zannetti A, De Renzo A, Di Gennaro F, Catalano L, Califano C, Pace L, Rotoli B, Salvatore M
Medicina Nucleare, Facoltà di Medicina, Università Federico II, via S. Pansini 5 (edificio 10), 80131 Naples, Italy
Centro Per la Medicina Nucleare C.N.R., Cattedra di Medicina Nucleare, Università Federico II, Napoli, Italy
Cattedra di Ematologia, Dipartimento di Medicina Clinica e Sperimentale, Università Federico II, Napoli, Italy
References: Wackers, F.J.T., Berman, D.S., Maddahi, J., Watson, D.D., Beller, G.A., Strauss, H.W., Boucher, C.A., McKusick, K., Tc-99m-hexakis 2-methoxy isobutylisonitrile: Human biodistribution, dosimetry, safety and preliminary comparison to thallium-201 for myocardial perfusion imaging (1989) J Nucl Med, 30, pp. 301-31
Khalkhali, I., Mena, I., Diggles, L., Review of imaging techniques for the diagnosis of breast cancer: A new role of prone scintimammography using technetium-99m-sestamibi (1994) Eur J Nucl Med, 21, pp. 357-362
Prats, E., Aisa, F., Abos, M.D., Villavieja, L., Garcia-Lopez, F., Asenjo, M.J., Razola, P., Banzo, J., Mammography and 99mTc-MIBI scintimammography in suspected breast cancer (1999) J Nucl Med, 40, pp. 296-301
Kao, C.H., Wang, S.J., Lin, W.Y., Hsu, C.Y., Liao, S.Q., Yeh, S.H., Differentiation of single-solid lesions in the lungs by means of single-photon emission tomography with technetium-99m-methoxyisobutylisonitrile (1993) Eur J Nucl Med, 20, pp. 249-254
Bom, H.S., Kim, Y.C., Song, H.C., Min, J.J., Kim, J.Y., Park, K.O., Technetium-99m-MIBI uptake in small cell lung cancer (1998) J Nucl Med, 39, pp. 91-94
Soler, C., Beauchesne, P., Maatougui, K., Schmitt, T., Barral, F.G., Michel, D., Dubois, F., Brunon, J., Technetium-99m sestamibi brain single-photon emission tomography for detection of recurrent gliomas after radiation therapy (1998) Eur J Nucl Med, 25, pp. 1649-1657
Foldes, I., Levay, A., Stotz, G., Comparative scanning of thyroid nodules with technetium-99m-methoxyisobutylisonitrile (1993) Eur J Nucl Med, 20, pp. 330-333
Tailefer, R., Boucher, Y., Potvin, C., Lambert, R., Detection and localization of parathyroid adenomas in patients with hyperparathyroidism using a single radionuclide imaging procedure with technetium-99m-sestamibi (double-phase study) (1992) J Nucl Med, 33, pp. 1801-1807
Soderlund, V., Jonsson, C., Bauer, H.C.F., Brosjo, O., Jacobsson, H., Comparison of technetium-99m-MIBI and technetium-99m-tetrofosmin uptake by musculoskeletal sarcomas (1997) J Nucl Med, 38, pp. 682-686
Ziegels, P., Nocaudie, M., Huglo, D., Deveaux, M., Detourmignies, L., Wattel, E., Marchandise, X., Comparison of technetium-99m methoxyisobutylisonitrile and gallium-67 citrate scanning in the assessment of lymphomas (1995) Eur J Nucl Med, 22, pp. 126-131
Tirovola, E.B., Biassoni, L., Britton, K.E., Kaleva, N., Kouykin, V., Malpas, J.S., The use of 99mTc-MIBI scanning in multiple myeloma (1996) Br J Cancer, 74, pp. 1815-1820
Adams, B.K., Fataar, A., Nizami, M.A., Technetium-99m-sestamibi uptake in myeloma (1996) J Nucl Med, 37, pp. 1001-1002
El-Shirbiny, A.M., Yeung, H., Imbriaco, M., Michaeli, J., Macapinlac, H., Larson, S.M., Technetium-99m-MIBI versus fluorine-18-FDG in diffuse multiple myeloma (1997) J Nucl Med, 38, pp. 1208-1210
Pace, L., Catalano, L., Pinto, A.M., De Renzo, A., Di Gennaro, F., Califano, C., Del Vecchio, S., Salvatore, M., Different patterns of technetium-99m sestamibi uptake in multiple myeloma (1998) Eur J Nucl Med, 25, pp. 714-720
Catalano, L., Pace, L., Califano, C., Pinto, A.M., De Renzo, A., Di Gennaro, F., Del Vecchio, S., Rotoli, B., Detection of focal myeloma lesions by technetium-99m-sestaMIBI scintigraphy (1999) Haematologica, 84, pp. 119-124
Piwnica-Worms, D., Kronauge, J.F., Chiu, M.L., Uptake and retention of hexaxis (2-methoxyisobutyl isonitrile) technetium (I) in cultured chick myocardial cells: Mitochondrial and plasma membrane potential dependence (1990) Circulation, 82, pp. 1826-1838
Chen, L.B., Summerhayes, I.C., Nadakavukaren, K.K., Lampidis, T.J., Bernal, S.D., Shepherd, E.L., Mitochondria in tumor cells: Effect of cytoskeleton on distribution and as targets for selective killing (1984) Cancer cells: the transformed phenotype, pp. 75-85. , Feramisco J, Ozanne B, Stiles C, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory
Cutrone, J.A., Yospur, L.S., Khalkhali, I., Tolmos, J., Devito, A., Diggles, L., Vargas, M.P., French, S., Immunohistologic assessment of technetium-99m-MIBI uptake in benign and malignant breast lesions (1998) J Nucl Med, 39, pp. 449-453
Scopinaro, F., Schillaci, O., Scarpini, M., Mingazzini, P.M., Di Macio, L., Banci, M., Danieli, R., Centicoletta, A., Technetium-99m sestamibi as an indicator of breast cancer invasiveness (1994) Eur J Nucl Med, 21, pp. 984-987
Delmon-Moingeon, L.I., Piwnica-Worms, D., Van den Abbeele, A.D., Holman, L., Davidson, A., Jones, A.G., Uptake of the cation hexaxis (2-methoxyisobutylisonitrile)-technetium-99m by human carcinoma cell lines in vitro (1990) Cancer Res, 50, pp. 2198-2202
Chiu, M.L., Kronauge, J.F., Piwnica-Worms, D., Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile)technetium(I) in cultured mouse fibroblasts (1990) J Nucl Med, 31, pp. 1646-1653
Crankshaw, C.L., Marmion, M., Luker, G.D., Vallabhaneni, R., Dahleimer, J., Burleigh, D., Webb, E., Piwnica-Worms, D., Novel technetium (III)-Q complexes for functional imaging of multidrug resistance (MDR1) P-glycoprotein (1998) J Nucl Med, 39, pp. 77-86
Isaksson, E., Bjorkholm, M., Holm, G., Johnasson, B., Nilsson, B., Mellstedt, H., Osterborg, A., Blood clonal B-cell excess in patients with monoclonal gammopathy of undetermined significance (MGUS): Association with malignant transformation (1996) Br J Haematol, 92, pp. 71-76
Masellis-Smith, A., Belch, A.R., Mant, M.J., Pilarski, L.M., Adhesion of multiple myeloma blood B cells to bone marrow fibroblasts: A requirement for CD44 and alpha4beta7 (1997) Cancer Res, 57, pp. 930-936
Szczepek, A.J., Seeberger, K., Wizniak, J., Mant, M.J., Belch, A.R., Pilarski, L.M., A high frequency of circulating B cells share clonotypic Ig heavy-chain VDJ rearrangements with autologous bone marrow plasma cells in multiple myeloma (1998) Blood, 92, pp. 2844-2855
Moretti, J.L., Cordobes, M.D., Starzec, A., De Beco, V., Vergote, J., Benazzoouz, F., Boissier, B., Kouyoumdjian, J.C., Involvement of glutathione in loss of technetium-99m-MIBI accumulation related to membrane MDR protein expression in tumor cells (1998) J Nucl Med, 39, pp. 1214-1218
Del Vecchio, S., Ciarmiello, A., Potena, M.I., Carriero, M.V., Mainolfi, C., Botti, G., Thomas, R., Salvatore, M., In vivo detection of multidrug-resistant (MDR1) phenotype by 99mTc-sestamibi scan in untreated breast cancer patients (1997) Eur J Nucl Med, 24, pp. 150-159
Bone marrow uptake of 99mTc-MIBI in patients with multiple myeloma
In a previous study, we showed the ability of technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) scan to identify active disease in patients with multiple myeloma (Eur J Nucl Med 1998; 25: 714-720). In particular, a semiquantitative score of the extension and intensity of bone marrow uptake was derived and correlated with both the clinical status of the disease and plasma cell bone marrow infiltration. In order to estimate quantitatively 99mTc-MIBI bone marrow uptake and to verify the intracellular localization of the tracer, bone marrow samples obtained from 24 multiple myeloma patients, three patients with monoclonal gammopathy of undetermined significance (MGUS) and two healthy donors were studied for in vitro uptake. After centrifugation over Ficoll-Hypaque gradient, cell suspensions were incubated with 99mTc-MIBI and the uptake was expressed as the percentage of radioactivity specifically retained within the cells. The cellular localization of the tracer was assessed by micro-autoradiography. Twenty-two out of 27 patients underwent 99mTc-MIBI scan within a week of bone marrow sampling. Whole-body images were obtained 10 min after intravenous injection of 555 MBq of the tracer; the extension and intensity of 99mTc-MIBI uptake were graded using the semiquantitative score. A statistically significant correlation was found between in vitro uptake of 99mTc-MIBI and both plasma cell infiltration (Pearson's coefficient of correlation r=0.69, P<0.0001) and in vivo score (Spearman rank correlation coefficient r=0.60, P<0.01). No specific tracer uptake was found in bone marrow samples obtained from the two healthy donors. Micro-autoradiography showed localization of 99mTc-MIBI inside the plasma cells infiltrating the bone marrow. Therefore, our findings show that the degree of tracer uptake both in vitro and in vivo is related to the percentage of infiltrating plasma cells which accumulate the tracer in their inner compartments.
Bone marrow uptake of 99mTc-MIBI in patients with multiple myeloma
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(449 views) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 ViewExport to BibTeXExport to EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(730 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote