Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (576 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.925, 5-year impact factor: 5.866
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79951786420&partnerID=40&md5=67a00463edef545d46da93e7514bdafb
Keywords: Copper, Ide, Metalloenzymes, Zinc, Alzheimer, S Disease, Bio-Molecular, Computational Investigation, Copper (ii), Enzymatic Activities, Inhibitory Effect, Insulin-Degrading Enzymes, Kinetic Study, Metal Homeostasis, Metallo-Protease, Molecular Basis, Monovalent Cations, Normal Condition, Peptide Fragments, Substrate Modifications, Degradation, Enzyme Activity, Enzyme Inhibition, Integrodifferential Equations, Mass Spectrometry, Metal Ions, Neurodegenerative Diseases, Zinc Compounds, Aluminum, Amyloid Beta Protein, Cysteine, Insulinase, Silver, Algorithm, Alzheimer Disease, Article, Chemistry, Computer Simulation, Drug Effect, Genetics, Human, Metabolism, Pathology, Sequence Homology, Amyloid Beta-Peptides, Insulysin, Amino Acid,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita di Catania, Catania, Italy.
Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, 95125, Catania, Italy
Consorzio I. N. B. B., Viale delle Medaglie d'Oro 305, 00136, Roma, Italy
Department of Experimental Medicine and Biochemical Sciences, University of Roma Tor Vergata, Via Montpellier 1, 00133 Roma, Italy
Interuniversity Consortium for the Research on the Chemistry of Metals in Biological Systems, Via C. Ulpiani 27, 70126 Bari, Italy
References:
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Crouch, P. J., Barnham, K. J., Bush, A. I., White, A. R., (2006) Drug News Perspect., 19, pp. 469-474
Filiz, G., Price, K. A., Caragounis, A., Du, T., Crouch, P. J., White, A. R., (2008) Eur. Biophys. J., 37, pp. 315-321
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Malito, E., Hulseb, R. E., Tang, W. J., (2008) Cell. Mol. Life Sci., 65, pp. 2574-2585
Grasso, G., Rizzarelli, E., Spoto, G., (2009) J. Mass Spectrom., 44, pp. 735-741
Crouch, P. J., Tew, D. J., Du, T., Nguyen, D. N., Caragounis, A., Filiz, G., Blake, R. E., White, A. R., (2009) J. Neurochem., 108, pp. 1198-1207
White, A. R., Du, T., Laughton, K. M., Volitakis, I., Sharples, R. A., Xilinas, M. E., Hoke, D. E., Masters, C. L., (2006) J. Biol. Chem., 281, pp. 17670-17680
Crouch, P. J., Hung, L. W., Adlard, P. A., Cortes, M., Lal, V., Filiz, G., Perez, K. A., Barnham, K. J., (2009) Proc. Natl. Acad. Sci. USA, 106, pp. 381-386
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Farris, W., Leissring, M. A., Hemming, M. L., Chang, A. Y., Selkoe, D., (2005) Biochemistry, 44, pp. 6513-6525
Luchsinger, J. A., Tang, M. -X., Shea, S., Mayeux, R., (2004) Neurology, 63, pp. 1187-1192
Miners, J. S., Baig, S., Tayler, H., Kehoe, P. G., Love, S., (2009) J. Neuropathol. Exp. Neurol., 68, pp. 902-914
Shen, Y., Joachimiak, A., Rosner, M. R., Tang, W. J., (2006) Nature, 443, pp. 870-874
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Malito, E., Ralat, L. A., Manolopoulou, M., Tsay, J. L., Wadlington, N. L., Tang, W. J., (2008) Biochemistry, 47, pp. 12822-12834
Neant-Fery, M., Garcia-Ordo ez, R. D., Logan, T. P., Selkoe, D. J., Li, L., Reinstatler, L., Leissring, M. A., (2008) Proc. Natl. Acad. Sci. USA, 105, pp. 9582-9587
Ralat, L. A., Ren, M., Schilling, A. B., Tang, W., (2009) J. Biol. Chem., 284, pp. 34005-34018
Cordes, C. M., Bennett, R. G., Siford, G. L., Hamel, F. G., (2009) Biochem. Pharmacol., 77, pp. 1064-1073
Ciaccio, C., Tundo, G. F., Grasso, G., Spoto, G., Marasco, D., Ruvo, M., Marini, S., Coletta, M., (2009) J. Mol. Biol., 385, pp. 1556-1567
Graham, S. C., Bond, C. S., Freeman, H. C., Guss, J. M., (2005) Biochemistry, 44, pp. 13820-13836
R zga, M., Protas, A. M., Jabonowska, A., Dadlez, M., Bal, W., (2009) Chem. Commun., pp. 1374-1376
Tanzi, R. E., Moir, R. D., Wagner, S. L., (2004) Neuron, 43, pp. 605-608
Gaggelli, E., Kozlowski, H., Valensin, D., Valensin, G., (2006) Chem. Rev., 106, pp. 1995-2004
Guo, Q., Manolopoulou, M., Bian, Y., Schilling, A. B., Tang, W. J., (2010) J. Mol. Biol., 395, pp. 430-443
Damante, C. A., Osz, K., Nagy, Z., Pappalardo, G., Grasso, G., Impellizzeri, G., Rizzarelli, E., Sovago, I., (2008) Inorg. Chem., 47, pp. 9669-9683
Zhao, J., Li, L., Leissring, M. A., (2009) Mol. Neurodegener., 4, p. 4
Cotton, F. A., Wilkinson, G., (1980) Advanced Inorganic Chemistry: A Comprehensive Text, , in, 4 th ed., Wiley, New York
Liang, H. C., Kim, E., Incarvito, C. D., Rheingold, A. L., Karlin, K. D., (2002) Inorg. Chem., 41, pp. 2209-2212
Im, H., Manolopoulou, M., Malito, E., Shen, Y., Zhao, J., Neant-Fery, M., Sun, C. Y., Tang, W. J., (2007) J. Biol. Chem., 282, pp. 25453-25463
Hoops, S. C., Anderson, K. W., Merz, Jr. K. M., (1991) J. Am. Chem. Soc., 113, pp. 8262-8270
Phillips, J. C., Braun, R., Wang, W., Gumbart, J., (2005) J. Comput. Chem., 26, pp. 1781-1802
Jorgensen, W. L., Chandrasekhar, J., Madura, J. D., Impey, R. W., Klein, M. L., (1983) J. Chem. Phys., 79, pp. 926-935
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Arnesano, F., Banci, L., Bertini, I., Huffman, D. L., O'Halloran, T. V., (2001) Biochemistry, 40, pp. 1528-1539
Darden, T., York, D., Pedersen, L., (1993) J. Chem. Phys., 98, pp. 10089-10092
Shevchenko, A., (2001) Anal. Biochem., 296, pp. 279-283
Perez, A., Morelli, L., Cresto, J. C., Castano, E. M., (2000) Neurochem. Res., 25, pp. 247-255
R zga, M., Bal, W., (2010) Chem. Res. Toxicol., 23, pp. 298-308
Danielsson, J., Pierattelli, R., Banci, L., Graslund, A., (2007) FEBS J., 274, pp. 46-59
Minicozzi, V., Stellato, F., Comai, M., Serra, M. D., Potrich, C., Meyer-Klaucke, W., Morante, S., (2008) J. Biol. Chem., 283, pp. 10784-10792
Miura, T., Suzuki, K., Kohata, N., Takeuchi, H., (2000) Biochemistry, 39, pp. 7024-7031
Kozin, S. A., Zirah, S., Rebuffat, S., Hoa, G. H. B., Debey, P., (2001) Biochem. Biophys. Res. Commun., 285, pp. 959-964
Llovera, R. E., Detullio, M., Alonso, L. G., Leissring, M. A., Kaufman, S. B., Roher, A. E., Depratgay, G., Castano, E. M., (2008) J. Biol. Chem., 283, pp. 17039-17048
Bora, R. P., Ozbil, M., Prabhakar, R., (2010) J. Biol. Inorg. Chem., 15, pp. 485-495
Bora, R. P., Prabhakar, R., (2010) Biochemistry, 49, pp. 3947-3956
Amata, O., Marino, T., Russo, N., Toscano, M., (2009) J. Am. Chem. Soc., 131, pp. 14804-14811
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.925, 5-year impact factor: 5.866
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79951786420&partnerID=40&md5=67a00463edef545d46da93e7514bdafb
Keywords: Copper, Ide, Metalloenzymes, Zinc, Alzheimer, S Disease, Bio-Molecular, Computational Investigation, Copper (ii), Enzymatic Activities, Inhibitory Effect, Insulin-Degrading Enzymes, Kinetic Study, Metal Homeostasis, Metallo-Protease, Molecular Basis, Monovalent Cations, Normal Condition, Peptide Fragments, Substrate Modifications, Degradation, Enzyme Activity, Enzyme Inhibition, Integrodifferential Equations, Mass Spectrometry, Metal Ions, Neurodegenerative Diseases, Zinc Compounds, Aluminum, Amyloid Beta Protein, Cysteine, Insulinase, Silver, Algorithm, Alzheimer Disease, Article, Chemistry, Computer Simulation, Drug Effect, Genetics, Human, Metabolism, Pathology, Sequence Homology, Amyloid Beta-Peptides, Insulysin, Amino Acid,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita di Catania, Catania, Italy.
Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, 95125, Catania, Italy
Consorzio I. N. B. B., Viale delle Medaglie d'Oro 305, 00136, Roma, Italy
Department of Experimental Medicine and Biochemical Sciences, University of Roma Tor Vergata, Via Montpellier 1, 00133 Roma, Italy
Interuniversity Consortium for the Research on the Chemistry of Metals in Biological Systems, Via C. Ulpiani 27, 70126 Bari, Italy
References:
Butterfield, D. A., Reed, T., Newman, S. F., Sultana, R., (2007) Free Radical Biol. Med., 43, pp. 658-67
Dahlgren, K. N., Manelli, A. M., Stine, Jr. W. B., Baker, L. K., Kraft, G. A., Ladu, M. J., (2002) J. Biol. Chem., 277, pp. 32046-32053
Qiu, W. Q., Walsh, D. M., Ye, Z., Vekrellis, K., Zhang, J., Podlisny, M. B., Rosner, M. R., Selkoe, D. J., (1998) J. Biol. Chem., 273, pp. 32730-32738
Bolognin, S., Messori, L., Zatta, P., (2009) Neuromol. Med., 11, pp. 223-238
Williams, R. J. P., (2003) Inorg. Chim. Acta, 356, pp. 27-40
Bush, A. I., Tanzi, R. E., (2008) Neurotherapeutics, 5, pp. 421-432
Sensi, S. L., Paoletti, P., Bush, A. I., Sekler, I., (2009) Nat. Rev. Neurosci., 10, pp. 780-791
Hung, Y. H., Bush, A. I., Cherny, R. A., (2009) J. Biol. Inorg. Chem., 15, pp. 61-76
Crouch, P. J., Barnham, K. J., Bush, A. I., White, A. R., (2006) Drug News Perspect., 19, pp. 469-474
Filiz, G., Price, K. A., Caragounis, A., Du, T., Crouch, P. J., White, A. R., (2008) Eur. Biophys. J., 37, pp. 315-321
Borchardt, T., Camakaris, J., Cappai, R., Masters, C. L., Beyreuther, K., Multhaup, G., (1999) Biochem. J., 344, pp. 461-467
Bayer, T. A., Sch fer, S., Simons, A., Kemmling, A., Kamer, T., Tepests, R., Eckert, A., Multhaup, G., (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 14187-14192
Phinney, A. L., Drisaldi, B., Schmidt, S. D., Lugowski, S., Coronado, V., Liang, Y., Horne, P., Westaway, D., (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 14193-14198
Barrea, R. A., Chen, D., Irving, T. C., Dou, P. Q., (2009) J. Cell. Biochem., 108, pp. 96-105
Malito, E., Hulseb, R. E., Tang, W. J., (2008) Cell. Mol. Life Sci., 65, pp. 2574-2585
Grasso, G., Rizzarelli, E., Spoto, G., (2009) J. Mass Spectrom., 44, pp. 735-741
Crouch, P. J., Tew, D. J., Du, T., Nguyen, D. N., Caragounis, A., Filiz, G., Blake, R. E., White, A. R., (2009) J. Neurochem., 108, pp. 1198-1207
White, A. R., Du, T., Laughton, K. M., Volitakis, I., Sharples, R. A., Xilinas, M. E., Hoke, D. E., Masters, C. L., (2006) J. Biol. Chem., 281, pp. 17670-17680
Crouch, P. J., Hung, L. W., Adlard, P. A., Cortes, M., Lal, V., Filiz, G., Perez, K. A., Barnham, K. J., (2009) Proc. Natl. Acad. Sci. USA, 106, pp. 381-386
Hersh, L. B., (2006) Cell. Mol. Life Sci., 63, pp. 2432-2434
Lynch, J. A., George, A. M., Eisenhauer, P. B., Conn, K., Gao, W., Carreras, I., Wells, J. M., Fine, R. E., (2006) J. Neurosci. Res., 83, pp. 1262-1270
Kuo, W. -L., Gehm, B. D., Rosner, M. R., Li, W., Keller, G., (1994) J. Biol. Chem., 269, pp. 22599-22606
Farris, W., Leissring, M. A., Hemming, M. L., Chang, A. Y., Selkoe, D., (2005) Biochemistry, 44, pp. 6513-6525
Luchsinger, J. A., Tang, M. -X., Shea, S., Mayeux, R., (2004) Neurology, 63, pp. 1187-1192
Miners, J. S., Baig, S., Tayler, H., Kehoe, P. G., Love, S., (2009) J. Neuropathol. Exp. Neurol., 68, pp. 902-914
Shen, Y., Joachimiak, A., Rosner, M. R., Tang, W. J., (2006) Nature, 443, pp. 870-874
Becker, A. B., Roth, R. A., (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 3835-3839
Qiu, W. Q., Folstein, M. F., (2006) Neurobiol. Aging, 27, pp. 190-198
Malito, E., Ralat, L. A., Manolopoulou, M., Tsay, J. L., Wadlington, N. L., Tang, W. J., (2008) Biochemistry, 47, pp. 12822-12834
Neant-Fery, M., Garcia-Ordo ez, R. D., Logan, T. P., Selkoe, D. J., Li, L., Reinstatler, L., Leissring, M. A., (2008) Proc. Natl. Acad. Sci. USA, 105, pp. 9582-9587
Ralat, L. A., Ren, M., Schilling, A. B., Tang, W., (2009) J. Biol. Chem., 284, pp. 34005-34018
Cordes, C. M., Bennett, R. G., Siford, G. L., Hamel, F. G., (2009) Biochem. Pharmacol., 77, pp. 1064-1073
Ciaccio, C., Tundo, G. F., Grasso, G., Spoto, G., Marasco, D., Ruvo, M., Marini, S., Coletta, M., (2009) J. Mol. Biol., 385, pp. 1556-1567
Graham, S. C., Bond, C. S., Freeman, H. C., Guss, J. M., (2005) Biochemistry, 44, pp. 13820-13836
R zga, M., Protas, A. M., Jabonowska, A., Dadlez, M., Bal, W., (2009) Chem. Commun., pp. 1374-1376
Tanzi, R. E., Moir, R. D., Wagner, S. L., (2004) Neuron, 43, pp. 605-608
Gaggelli, E., Kozlowski, H., Valensin, D., Valensin, G., (2006) Chem. Rev., 106, pp. 1995-2004
Guo, Q., Manolopoulou, M., Bian, Y., Schilling, A. B., Tang, W. J., (2010) J. Mol. Biol., 395, pp. 430-443
Damante, C. A., Osz, K., Nagy, Z., Pappalardo, G., Grasso, G., Impellizzeri, G., Rizzarelli, E., Sovago, I., (2008) Inorg. Chem., 47, pp. 9669-9683
Zhao, J., Li, L., Leissring, M. A., (2009) Mol. Neurodegener., 4, p. 4
Cotton, F. A., Wilkinson, G., (1980) Advanced Inorganic Chemistry: A Comprehensive Text, , in, 4 th ed., Wiley, New York
Liang, H. C., Kim, E., Incarvito, C. D., Rheingold, A. L., Karlin, K. D., (2002) Inorg. Chem., 41, pp. 2209-2212
Im, H., Manolopoulou, M., Malito, E., Shen, Y., Zhao, J., Neant-Fery, M., Sun, C. Y., Tang, W. J., (2007) J. Biol. Chem., 282, pp. 25453-25463
Hoops, S. C., Anderson, K. W., Merz, Jr. K. M., (1991) J. Am. Chem. Soc., 113, pp. 8262-8270
Phillips, J. C., Braun, R., Wang, W., Gumbart, J., (2005) J. Comput. Chem., 26, pp. 1781-1802
Jorgensen, W. L., Chandrasekhar, J., Madura, J. D., Impey, R. W., Klein, M. L., (1983) J. Chem. Phys., 79, pp. 926-935
Fuchs, J. F., Nedev, H., Poger, D., Ferrand, M., Brenner, V., Dognon, J. P., Crouzy, S. J., (2006) Comput. Chem., 27, pp. 837-856
Arnesano, F., Banci, L., Bertini, I., Huffman, D. L., O'Halloran, T. V., (2001) Biochemistry, 40, pp. 1528-1539
Darden, T., York, D., Pedersen, L., (1993) J. Chem. Phys., 98, pp. 10089-10092
Shevchenko, A., (2001) Anal. Biochem., 296, pp. 279-283
Perez, A., Morelli, L., Cresto, J. C., Castano, E. M., (2000) Neurochem. Res., 25, pp. 247-255
R zga, M., Bal, W., (2010) Chem. Res. Toxicol., 23, pp. 298-308
Danielsson, J., Pierattelli, R., Banci, L., Graslund, A., (2007) FEBS J., 274, pp. 46-59
Minicozzi, V., Stellato, F., Comai, M., Serra, M. D., Potrich, C., Meyer-Klaucke, W., Morante, S., (2008) J. Biol. Chem., 283, pp. 10784-10792
Miura, T., Suzuki, K., Kohata, N., Takeuchi, H., (2000) Biochemistry, 39, pp. 7024-7031
Kozin, S. A., Zirah, S., Rebuffat, S., Hoa, G. H. B., Debey, P., (2001) Biochem. Biophys. Res. Commun., 285, pp. 959-964
Llovera, R. E., Detullio, M., Alonso, L. G., Leissring, M. A., Kaufman, S. B., Roher, A. E., Depratgay, G., Castano, E. M., (2008) J. Biol. Chem., 283, pp. 17039-17048
Bora, R. P., Ozbil, M., Prabhakar, R., (2010) J. Biol. Inorg. Chem., 15, pp. 485-495
Bora, R. P., Prabhakar, R., (2010) Biochemistry, 49, pp. 3947-3956
Amata, O., Marino, T., Russo, N., Toscano, M., (2009) J. Am. Chem. Soc., 131, pp. 14804-14811
Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease
Accumulation of neurotoxic amyloid-beta peptide (Abeta) and alteration of metal homeostasis (metallostasis) in the brain are two main factors that have been very often associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Abeta is constantly produced from the amyloidprecursor-protein APP precursor and immediately catabolized under normal conditions, whereas dysmetabolism of Abeta and/or metal ions seems to lead to a pathological deposition. Although insulin-degrading enzyme (IDE) is the main metalloprotease involved in Abeta degradation in the brain being up-regulated in some areas of AD brains, the role of IDE for the onset and development of AD is far from being understood. Moreover, the biomolecular mechanisms involved in the recognition and interaction between IDE and its substrates are still obscure. In spite of the important role of metals (such as copper, aluminum, and zinc), which has brought us to propose a "metal hypothesis of AD", a targeted study of the effect of metallostasis on IDE activity has never been carried out. In this work, we have investigated the role that various metal ions (i. e., Cu (2+), Cu (+), Zn (2+), Ag (+), and Al (3+)) play in modulating the interaction between IDE and two Abeta peptide fragments, namely Abeta (1-16) and Abeta (16-28). It was therefore possible to identify the direct effect that such metal ions have on IDE structure and enzymatic activity without interferences caused by metal-induced substrate modifications. Mass spectrometry and kinetic studies revealed that, among all the metal ions tested, only Cu (2+), Cu (+), and Ag (+) have an inhibitory effect on IDE activity. Moreover, the inhibition of copper (II) is reversed by adding zinc (II), whereas the monovalent cations affect the enzyme activity irreversibly. The molecular basis of their action on the enzyme is also discussed on the basis of computational investigations. Copyright 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Accumulation of neurotoxic amyloid-beta peptide (Abeta) and alteration of metal homeostasis (metallostasis) in the brain are two main factors that have been very often associated with neurodegenerative diseases, such as Alzheimer's disease (AD). Abeta is constantly produced from the amyloidprecursor-protein APP precursor and immediately catabolized under normal conditions, whereas dysmetabolism of Abeta and/or metal ions seems to lead to a pathological deposition. Although insulin-degrading enzyme (IDE) is the main metalloprotease involved in Abeta degradation in the brain being up-regulated in some areas of AD brains, the role of IDE for the onset and development of AD is far from being understood. Moreover, the biomolecular mechanisms involved in the recognition and interaction between IDE and its substrates are still obscure. In spite of the important role of metals (such as copper, aluminum, and zinc), which has brought us to propose a "metal hypothesis of AD", a targeted study of the effect of metallostasis on IDE activity has never been carried out. In this work, we have investigated the role that various metal ions (i. e., Cu (2+), Cu (+), Zn (2+), Ag (+), and Al (3+)) play in modulating the interaction between IDE and two Abeta peptide fragments, namely Abeta (1-16) and Abeta (16-28). It was therefore possible to identify the direct effect that such metal ions have on IDE structure and enzymatic activity without interferences caused by metal-induced substrate modifications. Mass spectrometry and kinetic studies revealed that, among all the metal ions tested, only Cu (2+), Cu (+), and Ag (+) have an inhibitory effect on IDE activity. Moreover, the inhibition of copper (II) is reversed by adding zinc (II), whereas the monovalent cations affect the enzyme activity irreversibly. The molecular basis of their action on the enzyme is also discussed on the basis of computational investigations. Copyright 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease
Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease
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Angeli A, Buonanno M, Donald WA, Monti SM, Supuran CT
* The zinc - but not cadmium - containing zeta-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids (279 views)
Bioorg Chem (ISSN: 1090-2120electronic, 0045-2068linking), 2018 Oct; 80: 261-265.
Impact Factor: 3.929
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Nastri F, Chino M, Maglio O, Bhagi-damodaran A, Lu Y, Lombardi A
* Design and engineering of artificial oxygen-activating metalloenzymes (224 views) (PDF 171 views)
Chem Soc Rev (ISSN: 0306-0012, 1460-4744), 2016 Sep 21; 45(18): 5020-5054.
Impact Factor: 38.618
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Del Prete S, De Luca V, De Simone G, Supuran CT, Capasso C
* Cloning, expression and purification of the complete domain of the eta-carbonic anhydrase from Plasmodium falciparum (352 views)
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2016 Jun; 31(sup4): 54-59.
Impact Factor: 4.293
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Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (399 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
View Export to BibTeX Export to EndNote
Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (422 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
View Export to BibTeX Export to EndNote
Chino M, Maglio O, Nastri F, Pavone V, Degrado WF, Lombardi A
* Artificial Diiron Enzymes with a de Novo Designed Four-Helix Bundle Structure (563 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2015; 2015(21): 3371-3390.
Impact Factor: 2.686
View Export to BibTeX Export to EndNote
Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (366 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Jul; 1844(7): 1289-1298.
Impact Factor: 4.882
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GrassoG, Magrì A, Bellia F, Pietropaolo A, La Mendola D, Rizzarelli E
* The Copper (ii) And Zinc (ii) Coordination Mode Of Hexxh And Hxxeh Motif In Small Peptides: The Role Of Carboxylate Location And Hydrogen Bonding Network (526 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Jan; 130(1): 92-102.
Impact Factor: 3.444
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Turi I, DSanna D, Garribba E, Pappalardo G, Sóvágó I
* The effect of non-coordinating side chains on the metal binding affinities of peptides of histidine (425 views)
Polyhedron (ISSN: 0277-5387), 2013 Oct 7; 62: 7-17.
Impact Factor: 2.047
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Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
* Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein (481 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jul; 112: 17-24.
Impact Factor: 3.197
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Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) complexes of rat amylin fragments (357 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721.
Impact Factor: 3.838
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Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (469 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
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Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (402 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E
* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (494 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Nov 4; 114(43): 13830-13838.
Impact Factor: 3.603
View Export to BibTeX Export to EndNote
Di Natale G, Pappalardo G, Milardi D, Sciacca MFM, Attanasio F, La Mendola D, Rizzarelli E
* Different Interactions Of Human And Avian Prion Proteins N-Terminal Tandem Repeat Peptides And Their Copper (ii) Complexes With Model Membranes (385 views)
Journal Of Chemical Physics, 2010; 114: 13830-13838.
Impact Factor: 2.028
View Export to BibTeX Export to EndNote
Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Di Natale G, Osz K, Nagy Z, Sanna D, Micera G, Pappalardo G, Sovago I, Rizzarelli E
* The Interaction Of Copper (ii) With The Prion Peptide Fragment Huprp (76-114) Encompassing Four Histidyl Residues Within And Outside The Octarepeat Domain (323 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 May 4; 48(9): 4239-4250.
Impact Factor: 4.657
View Export to BibTeX Export to EndNote
Di Natale G, Damante CA, Nagy Z, Osz K, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) binding to two novel histidine-containing model hexapeptides: evidence for a metal ion driven turn conformation (423 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2008 Nov; 102(11): 2012-2019.
Impact Factor: 3.133
View Export to BibTeX Export to EndNote
Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (569 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
View Export to BibTeX Export to EndNote
Bonomo RP, Pappalardo G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (309 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2008 Sep 7; (29): 3805-3816.
Impact Factor: 3.58
View Export to BibTeX Export to EndNote
Pappalardo M, Sciacca MFM, Milardi D, Grasso DM, La Rosa C
* Thermodynamics Of Azurin Folding: The Role Of The Copper Ion (303 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2008 Sep; 93(2): 575-581.
Impact Factor: 1.63
View Export to BibTeX Export to EndNote
Bellia F, La Mendola D, Maccarrone G, Mineo P, Vitalini D, Scamporrino E, Sortino S, Vecchio G, Rizzarelli E
* Copper(II) Complexes With Beta-Cyclodextrin-Homocarnosine Conjugates And Their Antioxidant Activity (254 views)
Inorg Chim Acta (ISSN: 0020-1693), 2007 Feb 15; 360(3): 945-954.
Impact Factor: 1.713
View Export to BibTeX Export to EndNote
La Mendola D, Bonomo RP, Impellizzeri G, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E, Zito V
* Copper(II) complexes with chicken prion repeats: Influence of proline and tyrosine residues on the coordination features (303 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2005 Sep; 10(5): 463-475.
Impact Factor: 3.224
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (350 views)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
View Export to BibTeX Export to EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (429 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
View Export to BibTeX Export to EndNote
De Luca S, Bruno G, Fattorusso R, Isernia C, Pedone C, Morelli G
New synthetic tools for peptide-tetraphenylporphyrin derivatives (326 views)
Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1998 Jul; 5(4): 269-276.
Impact Factor: 0.557
View Export to BibTeX Export to EndNote
Tabbì G, Nauser T, Koppenol WH, Reedijk J
A Pulse Radiolysis Study of an Imidazolato-Bridged Asymmetric Dicopper(II) Complex: A Structural and Functional Mimic of Superoxide Dismutase (269 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 1998; (12): 1939-1943.
Impact Factor: 2.222
View Export to BibTeX Export to EndNote
Bonomo RP, Cucinotta V, D'Alessandro F, Impellizzeri G, Maccarrone G, Rizzarelli E, Vecchio G, Carima L, Corradini R, Sartor G, Marchelli R
Chiral recognition by the copper(ii) complex of 6-deoxy-6-n-(2 - methylaminopyridine)-β-cyclodextrin (378 views)
Chirality (ISSN: 0899-0042), 1997; 9(4): 341-349.
Impact Factor: 1.915
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* Exploring the Parallel G-Quadruplex Nucleic Acid World: A Spectroscopic and Computational Investigation on the Binding of the c-myc Oncogene NHE III1 Region by the Phytochemical Polydatin (24 views)
Molecules (ISSN: 1420-3049linking), 2022 May 7; 27(9): 2997-3006.
Impact Factor: 4.412
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Angeli A, Buonanno M, Donald WA, Monti SM, Supuran CT
* The zinc - but not cadmium - containing zeta-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids (279 views)
Bioorg Chem (ISSN: 1090-2120electronic, 0045-2068linking), 2018 Oct; 80: 261-265.
Impact Factor: 3.929
View Export to BibTeX Export to EndNote
Nastri F, Chino M, Maglio O, Bhagi-damodaran A, Lu Y, Lombardi A
* Design and engineering of artificial oxygen-activating metalloenzymes (224 views) (PDF 171 views)
Chem Soc Rev (ISSN: 0306-0012, 1460-4744), 2016 Sep 21; 45(18): 5020-5054.
Impact Factor: 38.618
View Export to BibTeX Export to EndNote
Del Prete S, De Luca V, De Simone G, Supuran CT, Capasso C
* Cloning, expression and purification of the complete domain of the eta-carbonic anhydrase from Plasmodium falciparum (352 views)
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2016 Jun; 31(sup4): 54-59.
Impact Factor: 4.293
View Export to BibTeX Export to EndNote
Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (399 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
View Export to BibTeX Export to EndNote
Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (422 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
View Export to BibTeX Export to EndNote
Chino M, Maglio O, Nastri F, Pavone V, Degrado WF, Lombardi A
* Artificial Diiron Enzymes with a de Novo Designed Four-Helix Bundle Structure (563 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2015; 2015(21): 3371-3390.
Impact Factor: 2.686
View Export to BibTeX Export to EndNote
Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (366 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Jul; 1844(7): 1289-1298.
Impact Factor: 4.882
View Export to BibTeX Export to EndNote
GrassoG, Magrì A, Bellia F, Pietropaolo A, La Mendola D, Rizzarelli E
* The Copper (ii) And Zinc (ii) Coordination Mode Of Hexxh And Hxxeh Motif In Small Peptides: The Role Of Carboxylate Location And Hydrogen Bonding Network (526 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Jan; 130(1): 92-102.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Turi I, DSanna D, Garribba E, Pappalardo G, Sóvágó I
* The effect of non-coordinating side chains on the metal binding affinities of peptides of histidine (425 views)
Polyhedron (ISSN: 0277-5387), 2013 Oct 7; 62: 7-17.
Impact Factor: 2.047
View Export to BibTeX Export to EndNote
Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
* Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein (481 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jul; 112: 17-24.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) complexes of rat amylin fragments (357 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721.
Impact Factor: 3.838
View Export to BibTeX Export to EndNote
Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (469 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (402 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E
* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (494 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Nov 4; 114(43): 13830-13838.
Impact Factor: 3.603
View Export to BibTeX Export to EndNote
Di Natale G, Pappalardo G, Milardi D, Sciacca MFM, Attanasio F, La Mendola D, Rizzarelli E
* Different Interactions Of Human And Avian Prion Proteins N-Terminal Tandem Repeat Peptides And Their Copper (ii) Complexes With Model Membranes (385 views)
Journal Of Chemical Physics, 2010; 114: 13830-13838.
Impact Factor: 2.028
View Export to BibTeX Export to EndNote
Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Di Natale G, Osz K, Nagy Z, Sanna D, Micera G, Pappalardo G, Sovago I, Rizzarelli E
* The Interaction Of Copper (ii) With The Prion Peptide Fragment Huprp (76-114) Encompassing Four Histidyl Residues Within And Outside The Octarepeat Domain (323 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 May 4; 48(9): 4239-4250.
Impact Factor: 4.657
View Export to BibTeX Export to EndNote
Di Natale G, Damante CA, Nagy Z, Osz K, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) binding to two novel histidine-containing model hexapeptides: evidence for a metal ion driven turn conformation (423 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2008 Nov; 102(11): 2012-2019.
Impact Factor: 3.133
View Export to BibTeX Export to EndNote
Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (569 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
View Export to BibTeX Export to EndNote
Bonomo RP, Pappalardo G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (309 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2008 Sep 7; (29): 3805-3816.
Impact Factor: 3.58
View Export to BibTeX Export to EndNote
Pappalardo M, Sciacca MFM, Milardi D, Grasso DM, La Rosa C
* Thermodynamics Of Azurin Folding: The Role Of The Copper Ion (303 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2008 Sep; 93(2): 575-581.
Impact Factor: 1.63
View Export to BibTeX Export to EndNote
Bellia F, La Mendola D, Maccarrone G, Mineo P, Vitalini D, Scamporrino E, Sortino S, Vecchio G, Rizzarelli E
* Copper(II) Complexes With Beta-Cyclodextrin-Homocarnosine Conjugates And Their Antioxidant Activity (254 views)
Inorg Chim Acta (ISSN: 0020-1693), 2007 Feb 15; 360(3): 945-954.
Impact Factor: 1.713
View Export to BibTeX Export to EndNote
La Mendola D, Bonomo RP, Impellizzeri G, Maccarrone G, Pappalardo G, Pietropaolo A, Rizzarelli E, Zito V
* Copper(II) complexes with chicken prion repeats: Influence of proline and tyrosine residues on the coordination features (303 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2005 Sep; 10(5): 463-475.
Impact Factor: 3.224
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (350 views)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
View Export to BibTeX Export to EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (429 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
View Export to BibTeX Export to EndNote
De Luca S, Bruno G, Fattorusso R, Isernia C, Pedone C, Morelli G
New synthetic tools for peptide-tetraphenylporphyrin derivatives (326 views)
Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1998 Jul; 5(4): 269-276.
Impact Factor: 0.557
View Export to BibTeX Export to EndNote
Tabbì G, Nauser T, Koppenol WH, Reedijk J
A Pulse Radiolysis Study of an Imidazolato-Bridged Asymmetric Dicopper(II) Complex: A Structural and Functional Mimic of Superoxide Dismutase (269 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 1998; (12): 1939-1943.
Impact Factor: 2.222
View Export to BibTeX Export to EndNote
Bonomo RP, Cucinotta V, D'Alessandro F, Impellizzeri G, Maccarrone G, Rizzarelli E, Vecchio G, Carima L, Corradini R, Sartor G, Marchelli R
Chiral recognition by the copper(ii) complex of 6-deoxy-6-n-(2 - methylaminopyridine)-β-cyclodextrin (378 views)
Chirality (ISSN: 0899-0042), 1997; 9(4): 341-349.
Impact Factor: 1.915
View Export to BibTeX Export to EndNote
30 Records (30 excluding Abstracts).
Total impact factor: 130.969 (130.969 excluding Abstracts).
Total 5 year impact factor: 131.794 (131.794 excluding Abstracts).
Total impact factor: 130.969 (130.969 excluding Abstracts).
Total 5 year impact factor: 131.794 (131.794 excluding Abstracts).
576 views. Last view on Thursday 09 February 2023, 17:48:53
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